BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC144657.4 + phase: 0 
         (776 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CLCG_ARATH (P60300) Putative chloride channel-like protein CLC-G     1118  0.0
CLCC_ARATH (Q96282) Chloride channel protein CLC-c (AtCLC-c)          924  0.0
CLCB_ARATH (P92942) Chloride channel protein CLC-b (AtCLC-b)          823  0.0
CLCA_ARATH (P92941) Chloride channel protein CLC-a (AtCLC-a)          811  0.0
CLCD_ARATH (P92943) Chloride channel protein CLC-d (AtCLC-d)          614  e-175
CLC7_HUMAN (P51798) Chloride channel protein 7 (ClC-7)                387  e-107
CLC7_RAT (P51799) Chloride channel protein 7 (ClC-7)                  386  e-106
CLC7_MOUSE (O70496) Chloride channel protein 7 (ClC-7)                386  e-106
CLC6_HUMAN (P51797) Chloride channel protein 6 (ClC-6)                326  1e-88
CLC6_MOUSE (O35454) Chloride channel protein 6 (ClC-6)                323  1e-87
CLC6_RABIT (Q9TT16) Chloride channel protein 6 (ClC-6)                321  5e-87
CLC5_RAT (P51796) Chloride channel protein 5 (ClC-5)                  191  8e-48
CLC5_MOUSE (Q9WVD4) Chloride channel protein 5 (ClC-5)                191  8e-48
CLC3_HUMAN (P51790) Chloride channel protein 3 (ClC-3)                190  1e-47
CLC3_RABIT (O18894) Chloride channel protein 3 (ClC-3)                189  2e-47
CLC3_RAT (P51792) Chloride channel protein 3 (ClC-3)                  189  3e-47
CLC3_MOUSE (P51791) Chloride channel protein 3 (ClC-3)                189  3e-47
CLC3_CAVPO (Q9R279) Chloride channel protein 3 (ClC-3)                189  3e-47
CLC2_RABIT (P51789) Chloride channel protein 2 (ClC-2) (PKA-acti...   169  3e-41
CLC5_HUMAN (P51795) Chloride channel protein 5 (ClC-5)                121  8e-27

>CLCG_ARATH (P60300) Putative chloride channel-like protein CLC-G
          Length = 763

 Score = 1118 bits (2891), Expect = 0.0
 Identities = 549/758 (72%), Positives = 642/758 (84%), Gaps = 2/758 (0%)

Query: 6   LSNGESEPLLRRPLLSSQRSIINSTSQVAIVGANVCPIESLDYEIFENEFFKQDWRSRGV 65
           + N  +E  +  PLL S R   NSTSQVAIVGANVCPIESLDYEI EN+FFKQDWR R  
Sbjct: 1   MPNSTTEDSVAVPLLPSLRRATNSTSQVAIVGANVCPIESLDYEIAENDFFKQDWRGRSK 60

Query: 66  VQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERRFMFAFFIFF 125
           V+I QY+ MKWLLCF IG+IV  IGF NNLAVENLAG+KFV TSNMM+  RF   F +F 
Sbjct: 61  VEIFQYVFMKWLLCFCIGIIVSLIGFANNLAVENLAGVKFVVTSNMMIAGRFAMGFVVFS 120

Query: 126 ASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIGSITAVSG 185
            +NL LTLFAS+ITAF+AP AAGSGI EVKAYLNGVDAP IF++RTL +KIIG+I+AVS 
Sbjct: 121 VTNLILTLFASVITAFVAPAAAGSGIPEVKAYLNGVDAPEIFSLRTLIIKIIGNISAVSA 180

Query: 186 SLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGSAAGIAAA 245
           SL+IGKAGPMVHTGACVA++LGQGGSKRY +TWRWLRFFKNDRDRRDL+ CG+AAGIAA+
Sbjct: 181 SLLIGKAGPMVHTGACVASILGQGGSKRYRLTWRWLRFFKNDRDRRDLVTCGAAAGIAAS 240

Query: 246 FRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLFGKGGLIM 305
           FRAPVGGVLFALEEM+SW  +ALLWR FF+TA VAI LRA+IDVCLS KCGLFGKGGLIM
Sbjct: 241 FRAPVGGVLFALEEMSSW--SALLWRIFFSTAVVAIVLRALIDVCLSGKCGLFGKGGLIM 298

Query: 306 FDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEKGTICRLFLACL 365
           FD YS + SYHL DV PV +L VVGG+LGSL+NF+ +KVLR YN I EKG   ++ LAC 
Sbjct: 299 FDVYSENASYHLGDVLPVLLLGVVGGILGSLYNFLLDKVLRAYNYIYEKGVTWKILLACA 358

Query: 366 ISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKFQCPPNHYNGLASLIFNTND 425
           ISIFTSCLLFGLP+LA C+PCP DA+E CPTIGRSG +KK+QCPP HYN LASLIFNTND
Sbjct: 359 ISIFTSCLLFGLPFLASCQPCPVDALEECPTIGRSGNFKKYQCPPGHYNDLASLIFNTND 418

Query: 426 DAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGI 485
           DAI+NLFS +TD EF   S+LVFF+ C FLSIFS GIVAPAGLFVP+IVTGASYGR VG+
Sbjct: 419 DAIKNLFSKNTDFEFHYFSVLVFFVTCFFLSIFSYGIVAPAGLFVPVIVTGASYGRFVGM 478

Query: 486 LVGERTNLSNGLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVA 545
           L+G  +NL++GL+AVLGAAS LGG+MR TVS CVI+LELTNNLLLLP++M+VL++SK+VA
Sbjct: 479 LLGSNSNLNHGLFAVLGAASFLGGTMRMTVSTCVILLELTNNLLLLPMMMVVLLISKTVA 538

Query: 546 NVFNANVYDLIMKAKGLPYLETHAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIVFILRTT 605
           + FNAN+Y+LIMK KG PYL +HAEPYMRQL VGDVVTGPLQ+FNGIEKV  IV +L+TT
Sbjct: 539 DGFNANIYNLIMKLKGFPYLYSHAEPYMRQLLVGDVVTGPLQVFNGIEKVETIVHVLKTT 598

Query: 606 AHNGFPVIDEPPGSEAPILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKK 665
            HNGFPV+D PP + AP+L G+ILR H+ TLLKK+ F+PSPVA   + + +F +++FAKK
Sbjct: 599 NHNGFPVVDGPPLAAAPVLHGLILRAHILTLLKKRVFMPSPVACDSNTLSQFKAEEFAKK 658

Query: 666 YSVERVKIEDIQLTEEEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIP 725
            S    KIED++L+EEE+ M++DLHPF+NASPYTVVETMSLAKALILFREVG+RHLLVIP
Sbjct: 659 GSGRSDKIEDVELSEEELNMYLDLHPFSNASPYTVVETMSLAKALILFREVGIRHLLVIP 718

Query: 726 KIPGRSPVVGILTRHDFTPEHILGMHPFLVKSRWKRLR 763
           K   R PVVGILTRHDF PEHILG+HP + +S+WKRLR
Sbjct: 719 KTSNRPPVVGILTRHDFMPEHILGLHPSVSRSKWKRLR 756


>CLCC_ARATH (Q96282) Chloride channel protein CLC-c (AtCLC-c)
          Length = 779

 Score =  924 bits (2387), Expect = 0.0
 Identities = 452/740 (61%), Positives = 557/740 (75%), Gaps = 3/740 (0%)

Query: 16  RRPLLSSQRSIINSTSQVAIVGANVCPIESLDYEIFENEFFKQDWRSRGVVQILQYICMK 75
           R+PLL+  R   N+TSQ+AIVGAN CPIESLDYEIFEN+FFKQDWRSR  ++ILQY  +K
Sbjct: 38  RQPLLARNRK--NTTSQIAIVGANTCPIESLDYEIFENDFFKQDWRSRKKIEILQYTFLK 95

Query: 76  WLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERRFMFAFFIFFASNLSLTLFA 135
           W L F+IGL  G +GF NNL VEN+AG K +   N+ML+ ++  AFF F   NL L   A
Sbjct: 96  WALAFLIGLATGLVGFLNNLGVENIAGFKLLLIGNLMLKEKYFQAFFAFAGCNLILATAA 155

Query: 136 SIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPM 195
           + + AFIAP AAGSGI EVKAYLNG+DA  I    TL VKI GSI  V+   V+GK GPM
Sbjct: 156 ASLCAFIAPAAAGSGIPEVKAYLNGIDAYSILAPSTLFVKIFGSIFGVAAGFVVGKEGPM 215

Query: 196 VHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGSAAGIAAAFRAPVGGVLF 255
           VHTGAC+A LLGQGGSK+Y +TW+WLRFFKNDRDRRDLI CG+AAG+AAAFRAPVGGVLF
Sbjct: 216 VHTGACIANLLGQGGSKKYRLTWKWLRFFKNDRDRRDLITCGAAAGVAAAFRAPVGGVLF 275

Query: 256 ALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLFGKGGLIMFDAYSASISY 315
           ALEE ASWWR ALLWR FFTTA VA+ LR++I+ C S +CGLFGKGGLIMFD  S  + Y
Sbjct: 276 ALEEAASWWRNALLWRTFFTTAVVAVVLRSLIEFCRSGRCGLFGKGGLIMFDVNSGPVLY 335

Query: 316 HLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEKGTICRLFLACLISIFTSCLLF 375
              D+  +  L V+GG+LGSL+N++ +KVLR Y++INEKG   ++ L   +SI +SC  F
Sbjct: 336 STPDLLAIVFLGVIGGVLGSLYNYLVDKVLRTYSIINEKGPRFKIMLVMAVSILSSCCAF 395

Query: 376 GLPWLAPCRPCPPDAVE-PCPTIGRSGIYKKFQCPPNHYNGLASLIFNTNDDAIRNLFSM 434
           GLPWL+ C PCP    E  CP++GRS IYK FQCPPNHYN L+SL+ NTNDDAIRNLF+ 
Sbjct: 396 GLPWLSQCTPCPIGIEEGKCPSVGRSSIYKSFQCPPNHYNDLSSLLLNTNDDAIRNLFTS 455

Query: 435 HTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILVGERTNLS 494
            ++NEF +S++ +FF+    L I + GI  P+GLF+P+I+ GASYGRLVG L+G  + L 
Sbjct: 456 RSENEFHISTLAIFFVAVYCLGIITYGIAIPSGLFIPVILAGASYGRLVGRLLGPVSQLD 515

Query: 495 NGLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYD 554
            GL+++LGAAS LGG+MR TVSLCVI+LELTNNLL+LPL+M+VL++SK+VA+ FN  VYD
Sbjct: 516 VGLFSLLGAASFLGGTMRMTVSLCVILLELTNNLLMLPLVMLVLLISKTVADCFNRGVYD 575

Query: 555 LIMKAKGLPYLETHAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTAHNGFPVID 614
            I+  KGLPY+E HAEPYMR L   DVV+G L  F+ +EKV  I   L+ T HNGFPVID
Sbjct: 576 QIVTMKGLPYMEDHAEPYMRNLVAKDVVSGALISFSRVEKVGVIWQALKMTRHNGFPVID 635

Query: 615 EPPGSEAPILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIE 674
           EPP +EA  L GI LR HL  LL+ K F          ++R   + DF K    + +KIE
Sbjct: 636 EPPFTEASELCGIALRSHLLVLLQGKKFSKQRTTFGSQILRSCKARDFGKAGLGKGLKIE 695

Query: 675 DIQLTEEEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVV 734
           D+ L+EEEM M+VDLHP TN SPYTV+ET+SLAKA ILFR++GLRHL V+PK PGR P+V
Sbjct: 696 DLDLSEEEMEMYVDLHPITNTSPYTVLETLSLAKAAILFRQLGLRHLCVVPKTPGRPPIV 755

Query: 735 GILTRHDFTPEHILGMHPFL 754
           GILTRHDF PEH+LG++P +
Sbjct: 756 GILTRHDFMPEHVLGLYPHI 775


>CLCB_ARATH (P92942) Chloride channel protein CLC-b (AtCLC-b)
          Length = 780

 Score =  823 bits (2126), Expect = 0.0
 Identities = 408/769 (53%), Positives = 547/769 (71%), Gaps = 18/769 (2%)

Query: 2   SNNHLSNGESEP-LLRRPLLSSQRSIINSTSQVAIVGANVCPIESLDYEIFENEFFKQDW 60
           SN +   G+ E   L +PL+ + R++  S++ +A+VGA V  IESLDYEI EN+ FK DW
Sbjct: 13  SNYNGEGGDPESNTLNQPLVKANRTL--SSTPLALVGAKVSHIESLDYEINENDLFKHDW 70

Query: 61  RSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERRFMFA 120
           R R   Q+LQY+ +KW L  ++GL  G I    NLAVEN+AG K +   + + + R++  
Sbjct: 71  RKRSKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTG 130

Query: 121 FFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIGSI 180
             +   +NL LTL AS++    APTAAG GI E+KAYLNGVD P +F   T+ VKI+GSI
Sbjct: 131 LMVLVGANLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSI 190

Query: 181 TAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGSAA 240
            AV+  L +GK GP+VH G+C+A+LLGQGG+  + I WRWLR+F NDRDRRDLI CGSAA
Sbjct: 191 GAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAA 250

Query: 241 GIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLFGK 300
           G+ AAFR+PVGGVLFALEE+A+WWR+ALLWR FF+TA V + LR  I++C S KCGLFGK
Sbjct: 251 GVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGK 310

Query: 301 GGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEKGTICRL 360
           GGLIMFD    + +YH+ D+ PV ++ V+GG+LGSL+N + +KVLR+YN+INEKG I ++
Sbjct: 311 GGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKV 370

Query: 361 FLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKFQCPPNHYNGLASLI 420
            L+  +S+FTS  L+GLP+LA C+PC P   E CPT GRSG +K+F CP  +YN LA+L+
Sbjct: 371 LLSLTVSLFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLL 430

Query: 421 FNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYG 480
             TNDDA+RNLFS +T NEF + S+ +FF++   L +F+ GI  P+GLF+PII+ GA+YG
Sbjct: 431 LTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYG 490

Query: 481 RLVGILVGERTNLSNGLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVV 540
           R++G  +G  T++  GLYAVLGAA+L+ GSMR TVSLCVI LELTNNLLLLP+ M+VL++
Sbjct: 491 RMLGAAMGSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLI 550

Query: 541 SKSVANVFNANVYDLIMKAKGLPYLETHAEPYMRQLTVGDV--VTGPLQMFNGIEKVRNI 598
           +K+V + FN ++YD+I+  KGLP+LE + EP+MR LTVG++     P+    G+EKV NI
Sbjct: 551 AKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNI 610

Query: 599 VFILRTTAHNGFPVIDEPP------GSEAPILFGIILRHHLTTLLKKKAFLPSP-VANSY 651
           V +L+ T HN FPV+DE         + A  L G+ILR HL  +LKK+ FL        +
Sbjct: 611 VDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEW 670

Query: 652 DVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHPFTNASPYTVVETMSLAKALI 711
           +V  KF  D+ A++        +D+ +T  EM M+VDLHP TN +PYTV+E MS+AKAL+
Sbjct: 671 EVREKFPWDELAERED----NFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALV 726

Query: 712 LFREVGLRHLLVIPKI--PGRSPVVGILTRHDFTPEHILGMHPFLVKSR 758
           LFR+VGLRHLL++PKI   G  PVVGILTR D    +IL   P L KS+
Sbjct: 727 LFRQVGLRHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSK 775


>CLCA_ARATH (P92941) Chloride channel protein CLC-a (AtCLC-a)
          Length = 775

 Score =  811 bits (2096), Expect = 0.0
 Identities = 406/772 (52%), Positives = 540/772 (69%), Gaps = 17/772 (2%)

Query: 3   NNHLSNGESEP------LLRRPLLSSQRSIINSTSQVAIVGANVCPIESLDYEIFENEFF 56
           +N   NGE E        L +PLL   R++  S++ +A+VGA V  IESLDYEI EN+ F
Sbjct: 10  SNSNYNGEEEGEDPENNTLNQPLLKRHRTL--SSTPLALVGAKVSHIESLDYEINENDLF 67

Query: 57  KQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERR 116
           K DWRSR   Q+ QYI +KW L  ++GL  G I    NLAVEN+AG K +     + + R
Sbjct: 68  KHDWRSRSKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGYYIAQDR 127

Query: 117 FMFAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKI 176
           F     +F  +NL LTL A+++  + APTAAG GI E+KAYLNG+D P +F   T+ VKI
Sbjct: 128 FWTGLMVFTGANLGLTLVATVLVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKI 187

Query: 177 IGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIIC 236
           +GSI AV+  L +GK GP+VH G+C+A+LLGQGG   + I WRWLR+F NDRDRRDLI C
Sbjct: 188 VGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITC 247

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCG 296
           GSA+G+ AAFR+PVGGVLFALEE+A+WWR+ALLWR FF+TA V + LRA I++C S KCG
Sbjct: 248 GSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICNSGKCG 307

Query: 297 LFGKGGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEKGT 356
           LFG GGLIMFD     + YH  D+ PV ++ V GG+LGSL+N + +KVLR+YN+IN+KG 
Sbjct: 308 LFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYNLINQKGK 367

Query: 357 ICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKFQCPPNHYNGL 416
           I ++ L+  +S+FTS  LFGLP+LA C+PC P   E CPT GRSG +K+F CP  +YN L
Sbjct: 368 IHKVLLSLGVSLFTSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCPNGYYNDL 427

Query: 417 ASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTG 476
           ++L+  TNDDA+RN+FS +T NEF + S+ +FF +   L + + GI  P+GLF+PII+ G
Sbjct: 428 STLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIILMG 487

Query: 477 ASYGRLVGILVGERTNLSNGLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMM 536
           ++YGR++G  +G  TN+  GLYAVLGAASL+ GSMR TVSLCVI LELTNNLLLLP+ M 
Sbjct: 488 SAYGRMLGTAMGSYTNIDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMF 547

Query: 537 VLVVSKSVANVFNANVYDLIMKAKGLPYLETHAEPYMRQLTVGDV--VTGPLQMFNGIEK 594
           VL+++K+V + FN ++Y++I+  KGLP+LE + EP+MR LTVG++     P+   NG+EK
Sbjct: 548 VLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEK 607

Query: 595 VRNIVFILRTTAHNGFPVIDEPPGSEAPILFGIILRHHLTTLLKKKAFL-PSPVANSYDV 653
           V NIV +LR T HN FPV+D    +    L G+ILR HL  +LKK+ FL        ++V
Sbjct: 608 VANIVDVLRNTTHNAFPVLDGADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRTEEWEV 667

Query: 654 VRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHPFTNASPYTVVETMSLAKALILF 713
             KF+  + A++        +D+ +T  EM ++VDLHP TN +PYTVV++MS+AKAL+LF
Sbjct: 668 REKFTPVELAERED----NFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLF 723

Query: 714 REVGLRHLLVIPKI--PGRSPVVGILTRHDFTPEHILGMHPFLVKSRWKRLR 763
           R VGLRHLLV+PKI   G SPV+GILTR D    +IL   P L K +  + R
Sbjct: 724 RSVGLRHLLVVPKIQASGMSPVIGILTRQDLRAYNILQAFPHLDKHKSGKAR 775


>CLCD_ARATH (P92943) Chloride channel protein CLC-d (AtCLC-d)
          Length = 792

 Score =  614 bits (1583), Expect = e-175
 Identities = 344/763 (45%), Positives = 479/763 (62%), Gaps = 28/763 (3%)

Query: 1   MSNNHLSNG-ESEPLLRRPLLSSQRSIINSTSQVAIVGANVCP---IESLDYEIFENEFF 56
           M +NHL NG ES+ LL   +  S  +   ST  + ++ ++      + SLDYE+ EN  +
Sbjct: 1   MLSNHLQNGIESDNLLWSRVPESDDT---STDDITLLNSHRDGDGGVNSLDYEVIENYAY 57

Query: 57  KQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERR 116
           +++   RG + +  Y+ +KW    +IG+  G      NL+VEN AG KF  T   ++++ 
Sbjct: 58  REEQAHRGKLYVGYYVAVKWFFSLLIGIGTGLAAVFINLSVENFAGWKFALTF-AIIQKS 116

Query: 117 FMFAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKI 176
           +   F ++   NL L   ++ I    AP AAGSGI E+K YLNG+D PG    RTL  KI
Sbjct: 117 YFAGFIVYLLINLVLVFSSAYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLLFRTLIGKI 176

Query: 177 IGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIIC 236
            GSI +V G L +GK GP+VHTGAC+A+LLGQGGS +Y +  RW + FK+DRDRRDL+ C
Sbjct: 177 FGSIGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDLVTC 236

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCG 296
           G AAG+AAAFRAPVGGVLFALEE+ SWWR+ L+WR FFT+A VA+ +R  +  C S  CG
Sbjct: 237 GCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGICG 296

Query: 297 LFGKGGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLR-IYNVINEKG 355
            FG GG I++D       Y+  ++ P+ ++ V+GGLLG+LFN +T  +     N +++KG
Sbjct: 297 HFGGGGFIIWDVSDGQDDYYFKELLPMAVIGVIGGLLGALFNQLTLYMTSWRRNSLHKKG 356

Query: 356 TICRLFLACLISIFTSCLLFGLPWLAPCRPCP---PDAVEPCP-TIGRSGIYKKFQC-PP 410
              ++  AC+IS  TS + FGLP L  C PCP   PD+   CP   G  G Y  F C   
Sbjct: 357 NRVKIIEACIISCITSAISFGLPLLRKCSPCPESVPDSGIECPRPPGMYGNYVNFFCKTD 416

Query: 411 NHYNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFV 470
           N YN LA++ FNT DDAIRNLFS  T  EF   S+L F  +   L++ + G   PAG FV
Sbjct: 417 NEYNDLATIFFNTQDDAIRNLFSAKTMREFSAQSLLTFLAMFYTLAVVTFGTAVPAGQFV 476

Query: 471 PIIVTGASYGRLVGILV---GERTNLSNGLYAVLGAASLLGGSMRTTVSLCVIMLELTNN 527
           P I+ G++YGRLVG+ V    ++ N+  G YA+LGAAS LGGSMR TVSLCVIM+E+TNN
Sbjct: 477 PGIMIGSTYGRLVGMFVVRFYKKLNIEEGTYALLGAASFLGGSMRMTVSLCVIMVEITNN 536

Query: 528 LLLLPLIMMVLVVSKSVANVFNANVYDLIMKAKGLPYLETHAEPYMRQLTVGDVV-TGPL 586
           L LLPLIM+VL++SK+V + FN  +Y++  + KG+P LE+  + +MRQ+   +   +  +
Sbjct: 537 LKLLPLIMLVLLISKAVGDAFNEGLYEVQARLKGIPLLESRPKYHMRQMIAKEACQSQKV 596

Query: 587 QMFNGIEKVRNIVFILRTTAHNGFPVIDEPPGSEAPILFGIILRHHLTTLLKKKA-FLPS 645
                + +V ++  IL +  HNGFPVID     E  ++ G++LR HL  LL+ K  F  S
Sbjct: 597 ISLPRVIRVADVASILGSNKHNGFPVIDHTRSGET-LVIGLVLRSHLLVLLQSKVDFQHS 655

Query: 646 PV---ANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHPFTNASPYTVVE 702
           P+    ++ ++   FS  +FAK  S + + IEDI LT +++ M++DL PF N SPY V E
Sbjct: 656 PLPCDPSARNIRHSFS--EFAKPVSSKGLCIEDIHLTSDDLEMYIDLAPFLNPSPYVVPE 713

Query: 703 TMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHDFTPE 745
            MSL K   LFR++GLRHL V+P+ P R  V+G++TR D   E
Sbjct: 714 DMSLTKVYNLFRQLGLRHLFVVPR-PSR--VIGLITRKDLLIE 753


>CLC7_HUMAN (P51798) Chloride channel protein 7 (ClC-7)
          Length = 805

 Score =  387 bits (994), Expect = e-107
 Identities = 247/710 (34%), Positives = 391/710 (54%), Gaps = 30/710 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+  EN+ F ++ R             +W++C +IG++ G +    ++ VENLAG+
Sbjct: 95  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 154

Query: 104 KF-VTTSNM---MLERRFMFAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLN 159
           K+ V   N+     +    F+  ++   N +  L  S+I AFI P AAGSGI ++K +LN
Sbjct: 155 KYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 214

Query: 160 GVDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWR 219
           GV  P +  ++TL +K+ G I +V G L +GK GPM+H+G+ +AA + QG S      ++
Sbjct: 215 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 274

Query: 220 WLRFFKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATV 279
              +F+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF +   
Sbjct: 275 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 334

Query: 280 AIFLRAMIDVCLSDKCGLFGKGGLIMFDAY-SASISYHLVDVPPVFILAVVGGLLGSLFN 338
              L  ++ +   +   L    GLI F  + S  ++Y + ++P    + VVGG+LG++FN
Sbjct: 335 TFTLNFVLSIYHGNMWDL-SSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393

Query: 339 FMTNKVLRIYNVINEKGTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIG 398
            + N  L ++ +        ++  A L++  T+ + F L  +   R C        P  G
Sbjct: 394 AL-NYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVL--IYSSRDCQ-------PLQG 443

Query: 399 RSGIYK-KFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSI 457
            S  Y  +  C    YN +A+  FNT + ++ +LF       +   ++ +F ++  FL+ 
Sbjct: 444 GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFH-DPPGSYNPLTLGLFTLVYFFLAC 502

Query: 458 FSCGIVAPAGLFVPIIVTGASYGRLVGI----LVGERTNLSNGLYAVLGAASLLGGSMRT 513
           ++ G+   AG+F+P ++ GA++GRL GI    L G       G YA++GAA+ LGG +R 
Sbjct: 503 WTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRM 562

Query: 514 TVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIMKAKGLPYLETHAEPYM 573
           T+SL VIM+E T+N+     IM+VL+ +K V +VF   +YD+ ++ + +P+L   A    
Sbjct: 563 TLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTS 622

Query: 574 RQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTA--HNGFPVIDEPPGSEAPILFGIILRH 631
             LT  +V++ P+      EKV  IV +L  TA  HNGFPV++    ++   L G+ILR 
Sbjct: 623 HSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRS 682

Query: 632 HLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHP 691
            L  LLK K F+    +N   V R+    DF   Y      I+ I ++++E    +DL  
Sbjct: 683 QLIVLLKHKVFVER--SNLGLVQRRLRLKDFRDAYP-RFPPIQSIHVSQDERECTMDLSE 739

Query: 692 FTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           F N SPYTV +  SL +   LFR +GLRHL+V   +  R+ VVG++TR D
Sbjct: 740 FMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNRNQVVGLVTRKD 786


>CLC7_RAT (P51799) Chloride channel protein 7 (ClC-7)
          Length = 803

 Score =  386 bits (992), Expect = e-106
 Identities = 246/710 (34%), Positives = 391/710 (54%), Gaps = 30/710 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+  EN+ F ++ R             +W++C +IG++ G +    ++ VENLAG+
Sbjct: 93  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 152

Query: 104 KF-VTTSNM---MLERRFMFAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLN 159
           K+ V   N+     +    F+  ++   N +  L  S+I AFI P AAGSGI ++K +LN
Sbjct: 153 KYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 212

Query: 160 GVDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWR 219
           GV  P +  ++TL +K+ G I +V G L +GK GPM+H+G+ +AA + QG S      ++
Sbjct: 213 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 272

Query: 220 WLRFFKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATV 279
              +F+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF +   
Sbjct: 273 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 332

Query: 280 AIFLRAMIDVCLSDKCGLFGKGGLIMFDAY-SASISYHLVDVPPVFILAVVGGLLGSLFN 338
              L  ++ +   +   L    GLI F  + S  ++Y + ++P    + VVGG+LG++FN
Sbjct: 333 TFTLNFVLSIYHGNMWDL-SSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFN 391

Query: 339 FMTNKVLRIYNVINEKGTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIG 398
            + N  L ++ +        ++  A L++  T+ + F L  +   R C        P  G
Sbjct: 392 AL-NYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVL--IYSSRDCQ-------PLQG 441

Query: 399 RSGIYK-KFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSI 457
            S  Y  +  C    YN +A+  FNT + ++ +LF       +   ++ +F ++  FL+ 
Sbjct: 442 SSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFH-DPPGSYNPMTLGLFTLVYFFLAC 500

Query: 458 FSCGIVAPAGLFVPIIVTGASYGRLVGI----LVGERTNLSNGLYAVLGAASLLGGSMRT 513
           ++ G+   AG+F+P ++ GA++GRL GI    L G       G YA++GAA+ LGG +R 
Sbjct: 501 WTYGLTVSAGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVRM 560

Query: 514 TVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIMKAKGLPYLETHAEPYM 573
           T+SL VIM+E T+N+     IM+VL+ +K V +VF   +YD+ ++ + +P+L   A    
Sbjct: 561 TLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTS 620

Query: 574 RQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTA--HNGFPVIDEPPGSEAPILFGIILRH 631
             LT  +V++ P+      EKV  IV +L  TA  HNGFPV+++   ++   L G+ILR 
Sbjct: 621 HSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRS 680

Query: 632 HLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHP 691
            L  LLK K F+    +N   V R+    DF   Y      I+ I ++++E    +DL  
Sbjct: 681 QLIVLLKHKVFVER--SNMGLVQRRLRLKDFRDAYP-RFPPIQSIHVSQDERECTMDLSE 737

Query: 692 FTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           F N SPYTV +  SL +   LFR +GLRHL+V   +   + VVG++TR D
Sbjct: 738 FMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNHNQVVGLVTRKD 784


>CLC7_MOUSE (O70496) Chloride channel protein 7 (ClC-7)
          Length = 803

 Score =  386 bits (992), Expect = e-106
 Identities = 246/710 (34%), Positives = 391/710 (54%), Gaps = 30/710 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+  EN+ F ++ R             +W++C +IG++ G +    ++ VENLAG+
Sbjct: 93  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 152

Query: 104 KF-VTTSNM---MLERRFMFAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLN 159
           K+ V   N+     +    F+  ++   N +  L  S+I AFI P AAGSGI ++K +LN
Sbjct: 153 KYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 212

Query: 160 GVDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWR 219
           GV  P +  ++TL +K+ G I +V G L +GK GPM+H+G+ +AA + QG S      ++
Sbjct: 213 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 272

Query: 220 WLRFFKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATV 279
              +F+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF +   
Sbjct: 273 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 332

Query: 280 AIFLRAMIDVCLSDKCGLFGKGGLIMFDAY-SASISYHLVDVPPVFILAVVGGLLGSLFN 338
              L  ++ +   +   L    GLI F  + S  ++Y + ++P    + VVGG+LG++FN
Sbjct: 333 TFTLNFVLSIYHGNMWDL-SSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFN 391

Query: 339 FMTNKVLRIYNVINEKGTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIG 398
            + N  L ++ +        ++  A L++  T+ + F L  +   R C        P  G
Sbjct: 392 AL-NYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVL--IYSSRDCQ-------PLQG 441

Query: 399 RSGIYK-KFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSI 457
            S  Y  +  C    YN +A+  FNT + ++ +LF       +   ++ +F ++  FL+ 
Sbjct: 442 SSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFH-DPPGSYNPMTLGLFTLVYFFLAC 500

Query: 458 FSCGIVAPAGLFVPIIVTGASYGRLVGI----LVGERTNLSNGLYAVLGAASLLGGSMRT 513
           ++ G+   AG+F+P ++ GA++GRL GI    L G       G YA++GAA+ LGG +R 
Sbjct: 501 WTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRM 560

Query: 514 TVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIMKAKGLPYLETHAEPYM 573
           T+SL VIM+E T+N+     IM+VL+ +K V +VF   +YD+ ++ + +P+L   A    
Sbjct: 561 TLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTS 620

Query: 574 RQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTA--HNGFPVIDEPPGSEAPILFGIILRH 631
             LT  +V++ P+      EKV  IV +L  TA  HNGFPV+++   ++   L G+ILR 
Sbjct: 621 HSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRS 680

Query: 632 HLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFVDLHP 691
            L  LLK K F+    +N   V R+    DF   Y      I+ I ++++E    +DL  
Sbjct: 681 QLIVLLKHKVFVER--SNMGLVQRRLRLKDFRDAYP-RFPPIQSIHVSQDERECTMDLSE 737

Query: 692 FTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           F N SPYTV +  SL +   LFR +GLRHL+V   +   + VVG++TR D
Sbjct: 738 FMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNHNQVVGLVTRKD 784


>CLC6_HUMAN (P51797) Chloride channel protein 6 (ClC-6)
          Length = 869

 Score =  326 bits (836), Expect = 1e-88
 Identities = 210/608 (34%), Positives = 331/608 (53%), Gaps = 32/608 (5%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+   N+ + +   +    +  +Y  +KW++ F IG+  G +G   +  V     +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQL 108

Query: 104 KF--VTTSNMMLERRFMFAFFIFFASNLSLT-LFASIITAFIAPTAAGSGISEVKAYLNG 160
           KF  V TS     ++   A  +      +LT +F + +   I P AAGSGI EVK YLNG
Sbjct: 109 KFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNG 168

Query: 161 VDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRW 220
           V  PGI  +RTL  K++G + +V+G L +GK GPM+H+G+ V A L Q  S    I+ R 
Sbjct: 169 VKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQS----ISLRK 224

Query: 221 LRF----FKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTT 276
           ++F    F++DRD+RD +  G+AAG+AAAF AP+GG LF+LEE +S+W   L W+  F +
Sbjct: 225 IQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCS 284

Query: 277 ATVAIFLRAMIDVCLSDKCGLFGKGGLIMFDAYSASIS------YHLVDVPPVFILAVVG 330
            +    L            G F   GL+ F  +  S S      +  +D+    ++ V+G
Sbjct: 285 MSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIG 344

Query: 331 GLLGSLFNFMTNKVLRIYNV--INEKGTICRLFLACLISIFTSCLLFGLPW-LAPCRPCP 387
           GLLG+ FN + NK L  Y +  ++ K  + R+  + L+S+ T+ ++F     L  CR   
Sbjct: 345 GLLGATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMS 403

Query: 388 P------DAVEPCPTIGRSGIYKKFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEFE 441
                  D+ +   T   +   K F CP + YN +A+L FN  + AI  LF  H D  F 
Sbjct: 404 SSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLF--HQDGTFS 461

Query: 442 LSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILVGERTNLSN---GLY 498
             ++ +FF++   L+ ++ GI  P+GLFVP ++ GA++GRLV  ++     L +   G +
Sbjct: 462 PVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTF 521

Query: 499 AVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIMK 558
           A++GAA+ LGG +R T+SL VI++E TN +     IM+ L+V+K   + FN  +YD+ + 
Sbjct: 522 ALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVG 581

Query: 559 AKGLPYLETHAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTAHNGFPVIDEPPG 618
            +G+P LE   E  M +L   D++   L       +++++V ILRTT H+ FPV+ E  G
Sbjct: 582 LRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRG 641

Query: 619 SEAPILFG 626
           +E   + G
Sbjct: 642 NEKEFMKG 649



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/127 (33%), Positives = 66/127 (51%), Gaps = 7/127 (5%)

Query: 622 PILF-GIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTE 680
           P+ F G+ILR  L TLL +        +++     + S  + A+ Y      I D+ LT 
Sbjct: 738 PLTFHGLILRSQLVTLLVRGVCYSESQSSASQP--RLSYAEMAEDYP-RYPDIHDLDLTL 794

Query: 681 EEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRH 740
               M VD+ P+ N SP+TV     +++   LFR +GLRHL V+  +     +VGI+TRH
Sbjct: 795 LNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAV---GEIVGIITRH 851

Query: 741 DFTPEHI 747
           + T E +
Sbjct: 852 NLTYEFL 858


>CLC6_MOUSE (O35454) Chloride channel protein 6 (ClC-6)
          Length = 870

 Score =  323 bits (828), Expect = 1e-87
 Identities = 208/609 (34%), Positives = 330/609 (54%), Gaps = 33/609 (5%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+   N+ + +   +    +  +Y  +KW++ F IG+  G +G   + +V     +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQL 108

Query: 104 KF--VTTSNMMLERRFMFAFFIFFASNLSLT-LFASIITAFIAPTAAGSGISEVKAYLNG 160
           KF  V TS     ++   A  +      +LT +F + +   I P AAGSGI E+K YLNG
Sbjct: 109 KFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNG 168

Query: 161 VDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRW 220
           V  PGI  +RTL  K+ G + +VSG L +GK GPM+H+GA V A L Q  S    I+ R 
Sbjct: 169 VKVPGIVRLRTLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQS----ISLRK 224

Query: 221 LRF----FKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTT 276
           ++F    F++DRD+RD +  G+AAG+AAAF AP+GG LF+LEE +S+W   L W+  F +
Sbjct: 225 IQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCS 284

Query: 277 ATVAIFLRAMIDVCLSDKCGLFGKGGLIMFDAYSASIS------YHLVDVPPVFILAVVG 330
            +    L            G F   GL+ F  +  S S      +  +D+    ++ V+G
Sbjct: 285 MSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIG 344

Query: 331 GLLGSLFNFMTNKVLRIYNV--INEKGTICRLFLACLISIFTSCLLFGLPW-LAPCRPCP 387
           GLLG+ FN + NK L  Y +  ++ K  + R+  + L+S+ T+ ++F     L  CR   
Sbjct: 345 GLLGATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMS 403

Query: 388 PDAVE-------PCPTIGRSGIYKKFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEF 440
             +            +   +   K F CP + YN +A+L FN+ + AI  LF  H D  F
Sbjct: 404 STSQTGNGSFQLQVTSEDVNSTIKAFFCPNDTYNDMATLFFNSQESAILQLF--HQDGTF 461

Query: 441 ELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILVGERTNLSN---GL 497
              ++ +FFI+   L+ ++ G   P+GLFVP ++ GA++GRLV  ++     L +   G 
Sbjct: 462 SPVTLALFFILYFLLACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHLYSGT 521

Query: 498 YAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIM 557
           +A++GAA+ LGG +R T+SL VI++E TN +     IM+ L+V+K   ++FN  +YD+ +
Sbjct: 522 FALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDLFNKGIYDVHI 581

Query: 558 KAKGLPYLETHAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTAHNGFPVIDEPP 617
             +G+P LE   +  M +L   D++   L       +++++V ILRTT H+ FPV+ E  
Sbjct: 582 GLRGVPLLEWETDVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENR 641

Query: 618 GSEAPILFG 626
           G+E   + G
Sbjct: 642 GNEKEFMKG 650



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 42/127 (33%), Positives = 66/127 (51%), Gaps = 7/127 (5%)

Query: 622 PILF-GIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTE 680
           P+ F G++LR  L TLL +        +++     + S  + A+ Y      I D+ LT 
Sbjct: 739 PLTFHGLVLRSQLVTLLVRGVCYSESQSSASQP--RLSYAEMAEDYP-RYPDIHDLDLTL 795

Query: 681 EEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRH 740
               M VD+ P+ N SP+TV     +++   LFR +GLRHL V+  +     +VGI+TRH
Sbjct: 796 LNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAV---GEIVGIITRH 852

Query: 741 DFTPEHI 747
           + T E +
Sbjct: 853 NLTNEFL 859


>CLC6_RABIT (Q9TT16) Chloride channel protein 6 (ClC-6)
          Length = 869

 Score =  321 bits (822), Expect = 5e-87
 Identities = 209/608 (34%), Positives = 329/608 (53%), Gaps = 32/608 (5%)

Query: 44  ESLDYEIFENEFFKQDWRSRGVVQILQYICMKWLLCFMIGLIVGFIGFCNNLAVENLAGI 103
           ESLDY+   N+ + +   +    +   Y  +KW + F IG+  G +G   +  V+    +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDHKKGRWYEVVKWTVVFAIGVCTGLVGLFVDFFVQLFTQL 108

Query: 104 KF--VTTSNMMLERRFMFAFFIFFASNLSLT-LFASIITAFIAPTAAGSGISEVKAYLNG 160
           KF  V  S     ++   A  +      +LT +F + +   I P AAGSGI E+K YLNG
Sbjct: 109 KFGVVEASVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNG 168

Query: 161 VDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRW 220
           V  PGI  +RTL  K+ G + +V+G L +GK GPM+H+GA V A L Q  S    I+ R 
Sbjct: 169 VKVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQS----ISLRK 224

Query: 221 LRF----FKNDRDRRDLIICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTT 276
           ++F    F++DRD+RD +  G+AAGIAAAF AP+G  LF+LEE +S+W   L W+  F +
Sbjct: 225 IQFNFPYFRSDRDKRDFVSAGAAAGIAAAFGAPIGATLFSLEEGSSFWNQGLTWKVLFCS 284

Query: 277 ATVAIFLRAMIDVCLSDKCGLFGKGGLIMFDAYSASIS------YHLVDVPPVFILAVVG 330
            +    L            G F   GL+ F  +  S S      +  +D+    ++ V+G
Sbjct: 285 MSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDMGFFVVMGVIG 344

Query: 331 GLLGSLFNFMTNKVLRIYNV--INEKGTICRLFLACLISIFTSCLLFGLPW-LAPCRPCP 387
           GLLG+ FN + NK L  Y +  ++ K  + R+  + L+S+ T+ ++F     L  CR   
Sbjct: 345 GLLGATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTLVVFVASMVLGECRQMS 403

Query: 388 PDA------VEPCPTIGRSGIYKKFQCPPNHYNGLASLIFNTNDDAIRNLFSMHTDNEFE 441
             +      ++   T   +   K F CP + YN +A+L FN  + AI  LF  H D  F 
Sbjct: 404 SSSQISNGSLKLQVTSDVNSSIKAFFCPNDTYNDMATLFFNPQESAILQLF--HQDGTFS 461

Query: 442 LSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILVGERTNLSN---GLY 498
             ++ +FF++   L+ ++ GI  P+GLFVP ++ GA++GRLV  ++     LS+   G +
Sbjct: 462 PITLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLSHIYSGTF 521

Query: 499 AVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVFNANVYDLIMK 558
           +++GAA+LLGG +R T+SL VI++E TN +     IM+ L+V+K   + FN  +YD+ + 
Sbjct: 522 SLIGAAALLGGVVRMTISLTVILIESTNEITYGLPIMITLMVAKWTGDFFNKGIYDIHVG 581

Query: 559 AKGLPYLETHAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIVFILRTTAHNGFPVIDEPPG 618
            +G+P LE   E  M +L   D++   L       +++++V ILRTT H+ FPV+ E  G
Sbjct: 582 LRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRG 641

Query: 619 SEAPILFG 626
           +E   + G
Sbjct: 642 NEKEFMKG 649



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 43/127 (33%), Positives = 66/127 (51%), Gaps = 7/127 (5%)

Query: 622 PILF-GIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTE 680
           P+ F G+ILR  L TLL +        +++     + S  + A+ Y      I D+ LT 
Sbjct: 738 PLTFHGLILRSQLVTLLVRGVCYSESQSSASQP--RLSYAEMAEDYP-RFPDIHDLDLTL 794

Query: 681 EEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRH 740
               M VD+ P+ N SP+TV     +++   LFR +GLRHL V+  +     +VGI+TRH
Sbjct: 795 LNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAV---GEIVGIVTRH 851

Query: 741 DFTPEHI 747
           + T E +
Sbjct: 852 NLTYEFL 858


>CLC5_RAT (P51796) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  191 bits (484), Expect = 8e-48
 Identities = 188/663 (28%), Positives = 300/663 (44%), Gaps = 92/663 (13%)

Query: 119 FAFFI-FFASNLSLTLFA----SIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLC 173
           FA+ + +F   L   LFA    S++ AF AP A GSGI E+K  L+G    G     TL 
Sbjct: 134 FAYIVNYFMYVLWALLFAFLAVSLVKAF-APYACGSGIPEIKTILSGFIIRGYLGKWTLV 192

Query: 174 VKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDL 233
           +K I  + AVS  L +GK GP+VH   C   +L    +K          + KN+  RR++
Sbjct: 193 IKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREV 242

Query: 234 IICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSD 293
           +   +AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++       
Sbjct: 243 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI------- 295

Query: 294 KCGLFGKGGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINE 353
               FG   L++F        +HL ++ P  +L + GGL G+LF   TN          +
Sbjct: 296 --NPFGNSRLVLF-YVEFHTPWHLFELVPFIVLGIFGGLWGALF-IRTNIAWCRKRKTTQ 351

Query: 354 KGTICRLFLACLISIFTSCLLFGLPWL-APCRPCPPDAVEPCPTIGRSGIYKKFQCPPNH 412
            G    +    +++  T+ L F   +          +    C  +  S    K     NH
Sbjct: 352 LGKY-PVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSS----KLCDYENH 406

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPI 472
           +N             +    +M     ++L+  L+  I+   ++IF+ G+  P+GLF+P 
Sbjct: 407 FNTSKGGELPDRPAGVGVYSAM-----WQLALTLILKIV---ITIFTFGMKIPSGLFIPS 458

Query: 473 IVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLGGSMRTT 514
           +  GA  GRL+G+ + +                     ++ GLYA++GAA+ LGG  R T
Sbjct: 459 MAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMT 518

Query: 515 VSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLETHAEPYM 573
           VSL VIM ELT  L  +  +M   + SK VA+      +YD  ++  G P+LE   E + 
Sbjct: 519 VSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEA-KEEFA 577

Query: 574 RQLTVGDVV----TGPL--QMFNGIEKVRNIVFILRTTAHNGFPVIDEPPGSEAPILFGI 627
            +    DV+      PL   +      V ++  I+  T ++GFPV+      E+  L G 
Sbjct: 578 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVV---VSRESQRLVGF 634

Query: 628 ILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFV 687
           +LR  L   ++        V  S  ++           Y+   +K+ +I          +
Sbjct: 635 VLRRDLIISIENARKKQDGVV-STSIIYFTEHSPPMPPYTPPTLKLRNI----------L 683

Query: 688 DLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHDFTPEHI 747
           DL      SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D   +HI
Sbjct: 684 DL------SPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKKDVL-KHI 732

Query: 748 LGM 750
             M
Sbjct: 733 AQM 735


>CLC5_MOUSE (Q9WVD4) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  191 bits (484), Expect = 8e-48
 Identities = 188/663 (28%), Positives = 300/663 (44%), Gaps = 92/663 (13%)

Query: 119 FAFFI-FFASNLSLTLFA----SIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLC 173
           FA+ + +F   L   LFA    S++ AF AP A GSGI E+K  L+G    G     TL 
Sbjct: 134 FAYIVNYFMYVLWALLFAFLAVSLVKAF-APYACGSGIPEIKTILSGFIIRGYLGKWTLV 192

Query: 174 VKIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDL 233
           +K I  + AVS  L +GK GP+VH   C   +L    +K          + KN+  RR++
Sbjct: 193 IKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREV 242

Query: 234 IICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSD 293
           +   +AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++       
Sbjct: 243 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI------- 295

Query: 294 KCGLFGKGGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINE 353
               FG   L++F        +HL ++ P  +L + GGL G+LF   TN          +
Sbjct: 296 --NPFGNSRLVLF-YVEFHTPWHLFELVPFIVLGIFGGLWGALF-IRTNIAWCRKRKTTQ 351

Query: 354 KGTICRLFLACLISIFTSCLLFGLPWL-APCRPCPPDAVEPCPTIGRSGIYKKFQCPPNH 412
            G    +    +++  T+ L F   +          +    C  +  S    K     NH
Sbjct: 352 LGKY-PVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSS----KLCDYENH 406

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPI 472
           +N             +    +M     ++L+  L+  I+   ++IF+ G+  P+GLF+P 
Sbjct: 407 FNTSKGGELPDRPAGVGIYSAM-----WQLALTLILKIV---ITIFTFGMKIPSGLFIPS 458

Query: 473 IVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLGGSMRTT 514
           +  GA  GRL+G+ + +                     ++ GLYA++GAA+ LGG  R T
Sbjct: 459 MAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMT 518

Query: 515 VSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLETHAEPYM 573
           VSL VIM ELT  L  +  +M   + SK VA+      +YD  ++  G P+LE   E + 
Sbjct: 519 VSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEA-KEEFA 577

Query: 574 RQLTVGDVV----TGPL--QMFNGIEKVRNIVFILRTTAHNGFPVIDEPPGSEAPILFGI 627
            +    DV+      PL   +      V ++  I+  T ++GFPV+      E+  L G 
Sbjct: 578 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVV---VSRESQRLVGF 634

Query: 628 ILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEEEMGMFV 687
           +LR  L   ++        V  S  ++           Y+   +K+ +I          +
Sbjct: 635 VLRRDLIISIENARKKQDGVV-STSIIYFTEHSPPMPPYTPPTLKLRNI----------L 683

Query: 688 DLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHDFTPEHI 747
           DL      SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D   +HI
Sbjct: 684 DL------SPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKKDVL-KHI 732

Query: 748 LGM 750
             M
Sbjct: 733 AQM 735


>CLC3_HUMAN (P51790) Chloride channel protein 3 (ClC-3)
          Length = 762

 Score =  190 bits (483), Expect = 1e-47
 Identities = 176/661 (26%), Positives = 286/661 (42%), Gaps = 108/661 (16%)

Query: 119 FAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIG 178
           +  +IF+A  LS    A  +    AP A GSGI E+K  L+G    G     TL +K I 
Sbjct: 153 YIMYIFWA--LSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 210

Query: 179 SITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGS 238
            + AV+  L +GK GP+VH   C   +           ++ + ++  N+  +R+++   S
Sbjct: 211 LVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAAS 260

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++           F
Sbjct: 261 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------NPF 311

Query: 299 GKGGLIMFDAYSASISYH----LVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEK 354
           G   L++F      + YH    L ++ P  +L V GGL G+   F+   +       + K
Sbjct: 312 GNSRLVLF-----YVEYHTPWYLFELFPFILLGVFGGLWGAF--FIRANIAWCRRRKSTK 364

Query: 355 GTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKF--QCPPNH 412
                +    +++  T+ + F  P+                 +  S + K+    C P  
Sbjct: 365 FGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPLE 409

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICL------FLSIFSCGIVAPA 466
            + L       ND     +     D    +      + +CL       +++F+ GI  P+
Sbjct: 410 SSSLCDY---RNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPS 466

Query: 467 GLFVPIIVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLG 508
           GLF+P +  GA  GR+VGI V +                     ++ GLYA++GAA+ LG
Sbjct: 467 GLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLG 526

Query: 509 GSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLET 567
           G  R TVSL VI+ ELT  L  +  +M  ++ SK V + F    +Y+  ++  G P+L+ 
Sbjct: 527 GVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA 586

Query: 568 HAEPYMRQLTVGDVVTGPLQ-------MFNGIEKVRNIVFILRTTAHNGFPVIDEPPGSE 620
             E      T+   V  P +       +      V +I  ++  T++NGFPVI      E
Sbjct: 587 KEEFEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVI---MSKE 643

Query: 621 APILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTE 680
           +  L G  LR  LT  ++        +  S  V        FA          +      
Sbjct: 644 SQRLVGFALRRDLTIAIESARKKQEGIVGSSRVC-------FA----------QHTPSLP 686

Query: 681 EEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRH 740
            E    + L    + SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ 
Sbjct: 687 AESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKK 742

Query: 741 D 741
           D
Sbjct: 743 D 743


>CLC3_RABIT (O18894) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  189 bits (480), Expect = 2e-47
 Identities = 177/660 (26%), Positives = 287/660 (42%), Gaps = 108/660 (16%)

Query: 119 FAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIG 178
           +  +IF+A  LS    A  +    AP A GSGI E+K  L+G    G     TL +K I 
Sbjct: 153 YIMYIFWA--LSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 210

Query: 179 SITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGS 238
            + AV+  L +GK GP+VH   C   +           ++ + ++  N+  +R+++   S
Sbjct: 211 LVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAAS 260

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++           F
Sbjct: 261 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------NPF 311

Query: 299 GKGGLIMFDAYSASISYH----LVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEK 354
           G   L++F      + YH    L ++ P  +L V GGL G+   F+   +       + K
Sbjct: 312 GNSRLVLF-----YVEYHTPWYLFELFPFILLGVFGGLWGAF--FIRANIAWCRRRKSTK 364

Query: 355 GTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKF--QCPPNH 412
                +    +++  T+ + F  P+                 +  S + K+    C P  
Sbjct: 365 FGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPLE 409

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICL------FLSIFSCGIVAPA 466
            + L       ND     +     D    +      + +CL       +++F+ GI  P+
Sbjct: 410 SSSLCDY---RNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPS 466

Query: 467 GLFVPIIVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLG 508
           GLF+P +  GA  GR+VGI V +                     ++ GLYA++GAA+ LG
Sbjct: 467 GLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLG 526

Query: 509 GSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLET 567
           G  R TVSL VI+ ELT  L  +  +M  ++ SK V + F    +Y+  ++  G P+L+ 
Sbjct: 527 GVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA 586

Query: 568 HAEPYMRQLTVGDVV-----TGPLQMFNGIE-KVRNIVFILRTTAHNGFPVIDEPPGSEA 621
             E +       DV+       PL +       V +I  ++  T++NGFPVI      E+
Sbjct: 587 -KEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVI---MSKES 642

Query: 622 PILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEE 681
             L G  LR  LT  ++        +  S  V        FA          +       
Sbjct: 643 QRLVGFALRRDLTIAIESARKKQEGIVGSSRVC-------FA----------QHTPSLPA 685

Query: 682 EMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           E    + L    + SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D
Sbjct: 686 ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKKD 741


>CLC3_RAT (P51792) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  189 bits (479), Expect = 3e-47
 Identities = 178/660 (26%), Positives = 287/660 (42%), Gaps = 108/660 (16%)

Query: 119 FAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIG 178
           +  +IF+A  LS    A  +    AP A GSGI E+K  L+G    G     TL +K I 
Sbjct: 153 YIMYIFWA--LSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 210

Query: 179 SITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGS 238
            + AV+  L +GK GP+VH   C   +           ++ + ++  N+  +R+++   S
Sbjct: 211 LVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAAS 260

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++           F
Sbjct: 261 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------NPF 311

Query: 299 GKGGLIMFDAYSASISYH----LVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEK 354
           G   L++F      + YH    L ++ P  +L V GGL G+   F+   +       + K
Sbjct: 312 GNSRLVLF-----YVEYHTPWYLFELFPFILLGVFGGLWGAF--FIRANIAWCRRRKSTK 364

Query: 355 GTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKF--QCPPNH 412
                +    +++  T+ + F  P+                 +  S + K+    C P  
Sbjct: 365 FGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPLE 409

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICL------FLSIFSCGIVAPA 466
            + L       ND     +     D    +      + +CL       +++F+ GI  P+
Sbjct: 410 SSSLCDY---RNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPS 466

Query: 467 GLFVPIIVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLG 508
           GLF+P +  GA  GR+VGI V +                     ++ GLYA++GAA+ LG
Sbjct: 467 GLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLG 526

Query: 509 GSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLET 567
           G  R TVSL VI+ ELT  L  +  +M  ++ SK V + F    +Y+  ++  G P+L+ 
Sbjct: 527 GVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA 586

Query: 568 HAEPYMRQLTVGDVV-----TGPLQMFNGIE-KVRNIVFILRTTAHNGFPVIDEPPGSEA 621
             E +       DV+       PL +       V +I  ++  T++NGFPVI      E+
Sbjct: 587 -KEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVI---MSKES 642

Query: 622 PILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEE 681
             L G  LR  LT  ++        V  S  V        FA          +       
Sbjct: 643 QRLVGFALRRDLTIAIESARKKQEGVVGSSRVC-------FA----------QHTPSLPA 685

Query: 682 EMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           E    + L    + SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D
Sbjct: 686 ESPRPLKLRSILDMSPFTVTDHTPMEIVVDVFRKLGLRQCLVTHN--GR--LLGIITKKD 741


>CLC3_MOUSE (P51791) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  189 bits (479), Expect = 3e-47
 Identities = 177/660 (26%), Positives = 287/660 (42%), Gaps = 108/660 (16%)

Query: 119 FAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIG 178
           +  +IF+A  LS    A  +    AP A GSGI E+K  L+G    G     TL +K I 
Sbjct: 153 YIMYIFWA--LSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 210

Query: 179 SITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGS 238
            + AV+  L +GK GP+VH   C   +           ++ + ++  N+  +R+++   S
Sbjct: 211 LVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAAS 260

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++           F
Sbjct: 261 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------NPF 311

Query: 299 GKGGLIMFDAYSASISYH----LVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEK 354
           G   L++F      + YH    L ++ P  +L V GGL G+   F+   +       + K
Sbjct: 312 GNSRLVLF-----YVEYHTPWYLFELFPFILLGVFGGLWGAF--FIRANIAWCRRRKSTK 364

Query: 355 GTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKF--QCPPNH 412
                +    +++  T+ + F  P+                 +  S + K+    C P  
Sbjct: 365 FGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPLE 409

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICL------FLSIFSCGIVAPA 466
            + L       ND     +     D    +      + +CL       +++F+ GI  P+
Sbjct: 410 SSSLCDY---RNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPS 466

Query: 467 GLFVPIIVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLG 508
           GLF+P +  GA  GR+VGI V +                     ++ GLYA++GAA+ LG
Sbjct: 467 GLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLG 526

Query: 509 GSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLET 567
           G  R TVSL VI+ ELT  L  +  +M  ++ SK V + F    +Y+  ++  G P+L+ 
Sbjct: 527 GVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA 586

Query: 568 HAEPYMRQLTVGDVV-----TGPLQMFNGIE-KVRNIVFILRTTAHNGFPVIDEPPGSEA 621
             E +       DV+       PL +       V +I  ++  T++NGFPVI      E+
Sbjct: 587 -KEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVI---MSKES 642

Query: 622 PILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEE 681
             L G  LR  LT  ++        +  S  V        FA          +       
Sbjct: 643 QRLVGFALRRDLTIAIESARKKQEGIVGSSRVC-------FA----------QHTPSLPA 685

Query: 682 EMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           E    + L    + SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D
Sbjct: 686 ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKKD 741


>CLC3_CAVPO (Q9R279) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  189 bits (479), Expect = 3e-47
 Identities = 177/660 (26%), Positives = 287/660 (42%), Gaps = 108/660 (16%)

Query: 119 FAFFIFFASNLSLTLFASIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIG 178
           +  +IF+A  LS    A  +    AP A GSGI E+K  L+G    G     TL +K I 
Sbjct: 153 YIMYIFWA--LSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 210

Query: 179 SITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGS 238
            + AV+  L +GK GP+VH   C   +           ++ + ++  N+  +R+++   S
Sbjct: 211 LVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAAS 260

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++           F
Sbjct: 261 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------NPF 311

Query: 299 GKGGLIMFDAYSASISYH----LVDVPPVFILAVVGGLLGSLFNFMTNKVLRIYNVINEK 354
           G   L++F      + YH    L ++ P  +L V GGL G+   F+   +       + K
Sbjct: 312 GNSRLVLF-----YVEYHTPWYLFELFPFILLGVFGGLWGAF--FIRANIAWCRRRKSTK 364

Query: 355 GTICRLFLACLISIFTSCLLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKF--QCPPNH 412
                +    +++  T+ + F  P+                 +  S + K+    C P  
Sbjct: 365 FGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPLE 409

Query: 413 YNGLASLIFNTNDDAIRNLFSMHTDNEFELSSMLVFFIICL------FLSIFSCGIVAPA 466
            + L       ND     +     D    +      + +CL       +++F+ GI  P+
Sbjct: 410 SSSLCDY---RNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPS 466

Query: 467 GLFVPIIVTGASYGRLVGILVGERTN------------------LSNGLYAVLGAASLLG 508
           GLF+P +  GA  GR+VGI V +                     ++ GLYA++GAA+ LG
Sbjct: 467 GLFIPSMAIGAIAGRIVGIAVEQLAYFHHDWFIFKEWCEVGADCITPGLYAMVGAAACLG 526

Query: 509 GSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NANVYDLIMKAKGLPYLET 567
           G  R TVSL VI+ ELT  L  +  +M  ++ SK V + F    +Y+  ++  G P+L+ 
Sbjct: 527 GVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA 586

Query: 568 HAEPYMRQLTVGDVV-----TGPLQMFNGIE-KVRNIVFILRTTAHNGFPVIDEPPGSEA 621
             E +       DV+       PL +       V +I  ++  T++NGFPVI      E+
Sbjct: 587 -KEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVI---MSKES 642

Query: 622 PILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAKKYSVERVKIEDIQLTEE 681
             L G  LR  LT  ++        +  S  V        FA          +       
Sbjct: 643 QRLVGFALRRDLTIAIESARKKQEGIVGSSRVC-------FA----------QHTPSLPA 685

Query: 682 EMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVIPKIPGRSPVVGILTRHD 741
           E    + L    + SP+TV +   +   + +FR++GLR  LV     GR  ++GI+T+ D
Sbjct: 686 ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN--GR--LLGIITKKD 741


>CLC2_RABIT (P51789) Chloride channel protein 2 (ClC-2)
           (PKA-activated chloride channel)
          Length = 898

 Score =  169 bits (428), Expect = 3e-41
 Identities = 145/578 (25%), Positives = 260/578 (44%), Gaps = 48/578 (8%)

Query: 76  WLLCFMIGLIVGFIGFCNNLAVENLAGIKFVTTSNMMLERRFMFAFFIFFASNLSLTLFA 135
           W+   ++GL++  + +  + A+   A ++     +  L    +  +  +    + L  F+
Sbjct: 94  WIFLVLLGLLMALVSWAMDYAIA--ACLQAQQWMSRGLNTNLLLQYLAWVTYPVVLITFS 151

Query: 136 SIITAFIAPTAAGSGISEVKAYLNGVDAPGIFTVRTLCVKIIGSITAVSGSLVIGKAGPM 195
           +  T  +AP A GSGI E+K  L GV      T++T   K+IG   A+   + +GK GP 
Sbjct: 152 AGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPF 211

Query: 196 VHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLIICGSAAGIAAAFRAPVGGVLF 255
           VH  +  AALL +  S   GI       ++N+    +++    A G+   F AP+GGVLF
Sbjct: 212 VHIASMCAALLSKFLSLFGGI-------YENESRNTEMLAAACAVGVGCCFAAPIGGVLF 264

Query: 256 ALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDKCGLFGKGGLIMFDAYSASISY 315
           ++E  ++++     WR FF  AT + F+  ++ V   D+  +      +    +     +
Sbjct: 265 SIEVTSTFFAVRNYWRGFF-AATFSAFIFRVLAVWNRDEETITA----LFKTRFRLDFPF 319

Query: 316 HLVDVPPVFILAVVGGLLGSLFNFMTNK---VLRIYNVINEKGTICRLFLACLISIFTSC 372
            L ++P   ++ +  G  G+LF ++  K   V+R    IN      RL    L+++  S 
Sbjct: 320 DLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLIST 379

Query: 373 LLFGLPWLAPCRPCPPDAVEPCPTIGRSGIYKKFQCPPNHYNGLASLIFNTNDDAIRNLF 432
           L F  P             E   T+  +  + +             L+      +    +
Sbjct: 380 LTFP-PGFGQFMAGQLSQKETLVTLFDNRTWVR-----------QGLVEELEPPSTSQAW 427

Query: 433 SMHTDNEFELSSMLVFFIICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILV----- 487
           S    N F   ++++F ++  ++S  +  I  P G F+P+ V GA++GRLVG  +     
Sbjct: 428 SPPRANVF--LTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFP 485

Query: 488 -GERTNLSN-----GLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVS 541
            G  T+ S      G YAV+GAA+ L G++  TVS  VI+ ELT  +  +  +M+ ++++
Sbjct: 486 DGIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILA 544

Query: 542 KSVANVFNANVYDLIMKAKGLPYLET--HAEPYMRQLTVGDVVTGPLQMFNGIEKVRNIV 599
            +VA     ++YD I++ K LPYL           ++ V D++   +         R++ 
Sbjct: 545 NAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLR 604

Query: 600 FILRTTAHNGFPVIDEPPGSEAPILFGIILRHHLTTLL 637
             L  T      +++ P   E+ IL G I R  +  LL
Sbjct: 605 LALHRTKGRTLALVESP---ESMILLGSIERTQVVALL 639


>CLC5_HUMAN (P51795) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  121 bits (303), Expect = 8e-27
 Identities = 77/223 (34%), Positives = 116/223 (51%), Gaps = 24/223 (10%)

Query: 119 FAFFI-FFASNLSLTLFASIITAFI---APTAAGSGISEVKAYLNGVDAPGIFTVRTLCV 174
           FA+ + +F   L   LFA +  + +   AP A GSGI E+K  L+G    G     TL +
Sbjct: 134 FAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVI 193

Query: 175 KIIGSITAVSGSLVIGKAGPMVHTGACVAALLGQGGSKRYGITWRWLRFFKNDRDRRDLI 234
           K I  + AVS  L +GK GP+VH   C   +L    +K          + KN+  RR+++
Sbjct: 194 KTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREVL 243

Query: 235 ICGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTATVAIFLRAMIDVCLSDK 294
              +AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF     A  LR++        
Sbjct: 244 SAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI-------- 295

Query: 295 CGLFGKGGLIMFDAYSASISYHLVDVPPVFILAVVGGLLGSLF 337
              FG   L++F        +HL ++ P  +L + GGL G+LF
Sbjct: 296 -NPFGNSRLVLF-YVEFHTPWHLFELVPFILLGIFGGLWGALF 336



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 93/326 (28%), Positives = 152/326 (46%), Gaps = 51/326 (15%)

Query: 450 IICLFLSIFSCGIVAPAGLFVPIIVTGASYGRLVGILVGERTN----------------- 492
           I+ + ++IF+ G+  P+GLF+P +  GA  GRL+G+ + +                    
Sbjct: 436 ILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGAD 495

Query: 493 -LSNGLYAVLGAASLLGGSMRTTVSLCVIMLELTNNLLLLPLIMMVLVVSKSVANVF-NA 550
            ++ GLYA++GAA+ LGG  R TVSL VIM ELT  L  +  +M   + SK VA+     
Sbjct: 496 CITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGRE 555

Query: 551 NVYDLIMKAKGLPYLETHAEPYMRQLTVGDVV----TGPL--QMFNGIEKVRNIVFILRT 604
            +YD  ++  G P+LE   E +  +    DV+      PL   +      V ++  I+  
Sbjct: 556 GIYDAHIRLNGYPFLEA-KEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISE 614

Query: 605 TAHNGFPVIDEPPGSEAPILFGIILRHHLTTLLKKKAFLPSPVANSYDVVRKFSSDDFAK 664
           T ++GFPV+      E+  L G +LR  L   ++        V  S  ++          
Sbjct: 615 TTYSGFPVV---VSRESQRLVGFVLRRDLIISIENARKKQDGVV-STSIIYFTEHSPPLP 670

Query: 665 KYSVERVKIEDIQLTEEEMGMFVDLHPFTNASPYTVVETMSLAKALILFREVGLRHLLVI 724
            Y+   +K+ +I          +DL      SP+TV +   +   + +FR++GLR  LV 
Sbjct: 671 PYTPPTLKLRNI----------LDL------SPFTVTDLTPMEIVVDIFRKLGLRQCLVT 714

Query: 725 PKIPGRSPVVGILTRHDFTPEHILGM 750
               GR  ++GI+T+ D   +HI  M
Sbjct: 715 HN--GR--LLGIITKKDVL-KHIAQM 735


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.328    0.143    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,013,741
Number of Sequences: 164201
Number of extensions: 3877644
Number of successful extensions: 12256
Number of sequences better than 10.0: 70
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 11873
Number of HSP's gapped (non-prelim): 174
length of query: 776
length of database: 59,974,054
effective HSP length: 118
effective length of query: 658
effective length of database: 40,598,336
effective search space: 26713705088
effective search space used: 26713705088
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 70 (31.6 bits)