BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC144503.4 - phase: 0 
         (366 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

MPK2_HUMAN (P36507) Dual specificity mitogen-activated protein k...   169  1e-41
MPK2_CHICK (Q90891) Dual specificity mitogen-activated protein k...   169  1e-41
MPK1_RABIT (P29678) Dual specificity mitogen-activated protein k...   167  5e-41
MPK1_RAT (Q01986) Dual specificity mitogen-activated protein kin...   166  9e-41
MPK1_MOUSE (P31938) Dual specificity mitogen-activated protein k...   166  9e-41
MPK1_HUMAN (Q02750) Dual specificity mitogen-activated protein k...   166  9e-41
MPK2_MOUSE (Q63932) Dual specificity mitogen-activated protein k...   166  1e-40
MPK1_CRIGR (Q63980) Dual specificity mitogen-activated protein k...   166  1e-40
MPK2_RAT (P36506) Dual specificity mitogen-activated protein kin...   165  2e-40
WIS1_SCHPO (P33886) Protein kinase wis1 (EC 2.7.1.-) (Protein ki...   164  4e-40
MPK1_SERCA (Q91447) Dual specificity mitogen-activated protein k...   162  2e-39
DSOR_DROME (Q24324) Dual specificity mitogen-activated protein k...   160  4e-39
MPK5_RAT (Q62862) Dual specificity mitogen-activated protein kin...   155  2e-37
PBS2_YEAST (P08018) Polymyxin B resistance protein kinase (EC 2....   153  8e-37
STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1....   151  2e-36
FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7...   151  2e-36
ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.1...   151  3e-36
STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1....   150  5e-36
STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1....   150  6e-36
MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.1.-)         149  1e-35

>MPK2_HUMAN (P36507) Dual specificity mitogen-activated protein
           kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
           (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
           (MEK2)
          Length = 400

 Score =  169 bits (427), Expect = 1e-41
 Identities = 107/310 (34%), Positives = 169/310 (54%), Gaps = 58/310 (18%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + ER++ +G+G+GG V KV HR +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 71  DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 130

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSL-----EGKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL     E K IP+E  L  V+  +LRGLAYL  +H 
Sbjct: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEE-ILGKVSIAVLRGLAYLREKHQ 189

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YM+PER+      G 
Sbjct: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERL-----QGT 242

Query: 257 YDAYAGDIWSLGVSILEFYMGRFPF----------------AVGRQGDWAS--------- 291
           + +   DIWS+G+S++E  +GR+P                   G +G+  S         
Sbjct: 243 HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPG 302

Query: 292 ------------------LMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASR 332
                             L+  I    PP+ P    +P+F++FV++CL ++P+ R     
Sbjct: 303 RPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKM 362

Query: 333 LLSHPFLVRN 342
           L +H F+ R+
Sbjct: 363 LTNHTFIKRS 372


>MPK2_CHICK (Q90891) Dual specificity mitogen-activated protein
           kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
           (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
           (MEK2)
          Length = 398

 Score =  169 bits (427), Expect = 1e-41
 Identities = 107/310 (34%), Positives = 170/310 (54%), Gaps = 58/310 (18%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + ER++ +G+G+GG V KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 69  DFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 128

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSL-----EGKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL     E K IP+E  L  V+  +LRGLAYL  +H 
Sbjct: 129 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEE-ILGKVSIAVLRGLAYLREKHQ 187

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 188 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 240

Query: 257 YDAYAGDIWSLGVSILEFYMGRFPF----------------AVGRQGD------WA---- 290
           + +   DIWS+G+S++E  +GR+P                   G +G+      WA    
Sbjct: 241 HYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAEGESHSVSPWARPPG 300

Query: 291 -----------------SLMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASR 332
                             L+  I    PP+ P    + +F++FV++CL ++P+ R     
Sbjct: 301 RPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADLKM 360

Query: 333 LLSHPFLVRN 342
           L++H F+ R+
Sbjct: 361 LMNHTFIKRS 370


>MPK1_RABIT (P29678) Dual specificity mitogen-activated protein
           kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1)
           (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1)
           (MEK1)
          Length = 392

 Score =  167 bits (422), Expect = 5e-41
 Identities = 104/306 (33%), Positives = 168/306 (53%), Gaps = 54/306 (17%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + E+++ +G+G+GG V+KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 66  DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 125

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL+        IP E  L  V+  +++GL YL  +H 
Sbjct: 126 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHK 184

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 185 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 237

Query: 257 YDAYAGDIWSLGVSILEFYMGRFP------------FAVGRQGDWA-------------- 290
           + +   DIWS+G+S++E  +GR+P            F    +GD A              
Sbjct: 238 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 297

Query: 291 -------------SLMCAICMSQPPEAPTTA-SPEFRDFVSRCLQRDPSRRWTASRLLSH 336
                         L+  I    PP+ P+   S EF+DFV++CL ++P+ R    +L+ H
Sbjct: 298 SYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVH 357

Query: 337 PFLVRN 342
            F+ R+
Sbjct: 358 AFIKRS 363


>MPK1_RAT (Q01986) Dual specificity mitogen-activated protein kinase
           kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1)
           (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1)
          Length = 392

 Score =  166 bits (420), Expect = 9e-41
 Identities = 104/306 (33%), Positives = 168/306 (53%), Gaps = 54/306 (17%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + E+++ +G+G+GG V+KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 66  DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 125

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL+        IP E  L  V+  +++GL YL  +H 
Sbjct: 126 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHK 184

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 185 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 237

Query: 257 YDAYAGDIWSLGVSILEFYMGRFP------------FAVGRQGDWA-------------- 290
           + +   DIWS+G+S++E  +GR+P            F    +GD A              
Sbjct: 238 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLS 297

Query: 291 -------------SLMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASRLLSH 336
                         L+  I    PP+ P+   S EF+DFV++CL ++P+ R    +L+ H
Sbjct: 298 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 357

Query: 337 PFLVRN 342
            F+ R+
Sbjct: 358 AFIKRS 363


>MPK1_MOUSE (P31938) Dual specificity mitogen-activated protein
           kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1)
           (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1)
           (MEK1)
          Length = 392

 Score =  166 bits (420), Expect = 9e-41
 Identities = 104/306 (33%), Positives = 168/306 (53%), Gaps = 54/306 (17%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + E+++ +G+G+GG V+KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 66  DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 125

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL+        IP E  L  V+  +++GL YL  +H 
Sbjct: 126 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHK 184

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 185 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 237

Query: 257 YDAYAGDIWSLGVSILEFYMGRFP------------FAVGRQGDWA-------------- 290
           + +   DIWS+G+S++E  +GR+P            F    +GD A              
Sbjct: 238 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLS 297

Query: 291 -------------SLMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASRLLSH 336
                         L+  I    PP+ P+   S EF+DFV++CL ++P+ R    +L+ H
Sbjct: 298 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 357

Query: 337 PFLVRN 342
            F+ R+
Sbjct: 358 AFIKRS 363


>MPK1_HUMAN (Q02750) Dual specificity mitogen-activated protein
           kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1)
           (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1)
           (MEK1)
          Length = 392

 Score =  166 bits (420), Expect = 9e-41
 Identities = 104/306 (33%), Positives = 168/306 (53%), Gaps = 54/306 (17%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + E+++ +G+G+GG V+KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 66  DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 125

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL+        IP E  L  V+  +++GL YL  +H 
Sbjct: 126 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHK 184

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 185 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 237

Query: 257 YDAYAGDIWSLGVSILEFYMGRFP------------FAVGRQGDWA-------------- 290
           + +   DIWS+G+S++E  +GR+P            F    +GD A              
Sbjct: 238 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 297

Query: 291 -------------SLMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASRLLSH 336
                         L+  I    PP+ P+   S EF+DFV++CL ++P+ R    +L+ H
Sbjct: 298 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 357

Query: 337 PFLVRN 342
            F+ R+
Sbjct: 358 AFIKRS 363


>MPK2_MOUSE (Q63932) Dual specificity mitogen-activated protein
           kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
           (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
           (MEK2)
          Length = 401

 Score =  166 bits (419), Expect = 1e-40
 Identities = 108/311 (34%), Positives = 167/311 (52%), Gaps = 59/311 (18%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + ER++ +G+G+GG V K  HR +G   A K+I+   + +VR QI RE+Q+L + +   +
Sbjct: 71  DFERISELGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSL-----EGKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL     E K IP E+ L  V+  +LRGLAYL  +H 
Sbjct: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREKHQ 189

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 242

Query: 257 YDAYAGDIWSLGVSILEFYMGRF------------------------------------- 279
           + +   DIWS+G+S++E  +GR+                                     
Sbjct: 243 HYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPG 302

Query: 280 -PFAVGRQGDWASLMCA------ICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTAS 331
            P +VG   D    M        I    PP+ P+   S +F++FV++CL ++P+ R    
Sbjct: 303 RPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLK 362

Query: 332 RLLSHPFLVRN 342
            L++H F+ R+
Sbjct: 363 LLMNHAFIKRS 373


>MPK1_CRIGR (Q63980) Dual specificity mitogen-activated protein
           kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1)
           (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1)
           (MEK1)
          Length = 393

 Score =  166 bits (419), Expect = 1e-40
 Identities = 122/386 (31%), Positives = 192/386 (49%), Gaps = 75/386 (19%)

Query: 3   PIQLPPPTSTGSATASGSPNNNNSRPQRRRRDHLTLPLPQRDTNLAVPLPLPPSGGSGGG 62
           PIQL P T  GSA    S    N    +++ + L L   QR+  L   L      G    
Sbjct: 8   PIQLNP-TPDGSAVNGTSSAETNLEALQKKLEELELEEQQRN-RLEAFLTQKQKVGE--- 62

Query: 63  GNGSGSGSGGASQQLVIPFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEES 122
                           +   + E+++ +G+G+GG V+KV H+ +G   A K+I+   + +
Sbjct: 63  ----------------LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA 106

Query: 123 VRRQIHREIQILRDVDDVNVVKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQ 177
           +R QI RE+Q+L + +   +V  + ++  + EI + +E+MDGGSL+        IP E  
Sbjct: 107 IRNQIIRELQVLHECNSPYIVGFYGVFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQI 165

Query: 178 LADVARQILRGLAYLHRRH-IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSS 236
           L  V+  +++GL YL  +H I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS 
Sbjct: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSF 223

Query: 237 VGTIAYMSPERINTDINDGQYDAYAGDIWSLGVSILEFYMGRFP------------FAVG 284
           VGT +YMSPER+      G + +   DIWS+G+S++E  +GR+P            F   
Sbjct: 224 VGTRSYMSPERL-----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQ 278

Query: 285 RQGDWA---------------------------SLMCAICMSQPPEAPT-TASPEFRDFV 316
            +GD A                            L+  I    P + P+   S EF+DFV
Sbjct: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPAKLPSGVFSLEFQDFV 338

Query: 317 SRCLQRDPSRRWTASRLLSHPFLVRN 342
           ++CL ++P+ R    +LL H F+ R+
Sbjct: 339 NKCLIKNPAERADLKQLLVHAFIKRS 364


>MPK2_RAT (P36506) Dual specificity mitogen-activated protein kinase
           kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2)
           (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2)
          Length = 400

 Score =  165 bits (417), Expect = 2e-40
 Identities = 108/310 (34%), Positives = 167/310 (53%), Gaps = 58/310 (18%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + ER++ +G+G+GG V K  HR +G   A K+I+   + +VR QI RE+Q+L + +   +
Sbjct: 71  DFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSL-----EGKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL     E K IP E+ L  V+  +LRGLAYL  +H 
Sbjct: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREKHQ 189

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 242

Query: 257 YDAYAGDIWSLGVSILEFYMGRFPF----------------AVGRQGDWAS--------- 291
           + +   DIWS+G+S++E  +GR+P                   G  G+  S         
Sbjct: 243 HYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPG 302

Query: 292 ------------------LMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASR 332
                             L+  I    PP+ P+   S +F++FV++CL ++P+ R     
Sbjct: 303 RPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKL 362

Query: 333 LLSHPFLVRN 342
           L +H F+ R+
Sbjct: 363 LTNHAFIKRS 372


>WIS1_SCHPO (P33886) Protein kinase wis1 (EC 2.7.1.-) (Protein
           kinase sty2)
          Length = 605

 Score =  164 bits (414), Expect = 4e-40
 Identities = 98/269 (36%), Positives = 146/269 (53%), Gaps = 8/269 (2%)

Query: 79  IPFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVD 138
           I  SE+ +L  +G G+ G VYK +H+  G   ALK I    EE+   QI  E+ IL    
Sbjct: 315 INMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAV 374

Query: 139 DVNVVKCHEMYDHNAEIQVLLEYMDGGSLEGKH---IPQENQLADVARQILRGLAYLHRR 195
              +V  +  +     + + +EYMD GS++  +   I  E  LA  A  +++GL  L   
Sbjct: 375 SPYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEE 434

Query: 196 H-IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDIND 254
           H I+HRD+KP+N+L+NS  QVK+ DFGV   L  ++   N  +G  +YM+PERI      
Sbjct: 435 HNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKTN--IGCQSYMAPERIRVGGPT 492

Query: 255 GQYDAYA--GDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQPPEAPTTASPEF 312
                Y    D+WSLG++ILE  +G +P+         + + AIC   PP  P + SPE 
Sbjct: 493 NGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEA 552

Query: 313 RDFVSRCLQRDPSRRWTASRLLSHPFLVR 341
           RDFV++CL ++PS R     L +HP+L++
Sbjct: 553 RDFVNKCLNKNPSLRPDYHELANHPWLLK 581


>MPK1_SERCA (Q91447) Dual specificity mitogen-activated protein
           kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1)
           (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1)
           (MEK1) (Fragment)
          Length = 388

 Score =  162 bits (409), Expect = 2e-39
 Identities = 102/308 (33%), Positives = 165/308 (53%), Gaps = 56/308 (18%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           + E+++ +G+G+GG V+KV H+ +G   A K+I+   + ++R QI RE+Q+L + +   +
Sbjct: 60  DFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 119

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +E+MDGGSL+        IP E  L  V+  +++GL YL  +H 
Sbjct: 120 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHK 178

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NSR ++K+ DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 179 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 231

Query: 257 YDAYAGDIWSLGVSILEFYMGRFP------------FAVGRQGDWA-------------- 290
           + +   DIWS+G+S++E  +GR+P            F    +GD                
Sbjct: 232 HYSVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPVEGDSPVTETSPRQRAPGRP 291

Query: 291 ---------------SLMCAICMSQPPEAPT-TASPEFRDFVSRCLQRDPSRRWTASRLL 334
                           L+  I    PP+ P      EF+DFV++CL ++P+ R    +L+
Sbjct: 292 MSSYGSDSRPPMAIFELLDYIVNEPPPKLPNGVFGSEFQDFVNKCLIKNPAERADLKQLM 351

Query: 335 SHPFLVRN 342
            H F+ R+
Sbjct: 352 IHAFIKRS 359


>DSOR_DROME (Q24324) Dual specificity mitogen-activated protein
           kinase kinase dSOR1 (EC 2.7.1.-) (Downstream of RAF)
           (MAPKK)
          Length = 393

 Score =  160 bits (406), Expect = 4e-39
 Identities = 102/287 (35%), Positives = 154/287 (53%), Gaps = 38/287 (13%)

Query: 83  ELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNV 142
           +LE+L  +GSG+GG V KV H       A K+I+   + ++++QI RE+++L + +  ++
Sbjct: 83  DLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHI 142

Query: 143 VKCHEMYDHNAEIQVLLEYMDGGSLE-----GKHIPQENQLADVARQILRGLAYLHRRH- 196
           V  +  +  + EI + +EYMDGGSL+        IP E+ L  +   +L+GL+YL   H 
Sbjct: 143 VGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIP-ESILGRITLAVLKGLSYLRDNHA 201

Query: 197 IVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQ 256
           I+HRD+KPSN+L+NS  ++KI DFGV   L  +M   NS VGT +YMSPER+      G 
Sbjct: 202 IIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERL-----QGT 254

Query: 257 YDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMC--AICMSQPPEAPTTA------ 308
           + +   DIWSLG+S++E  +G +P          S+    A    QP + P         
Sbjct: 255 HYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELL 314

Query: 309 ----------------SPEFRDFVSRCLQRDPSRRWTASRLLSHPFL 339
                           S EF+DFV  CL++ P  R     LLSHP++
Sbjct: 315 DYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 361


>MPK5_RAT (Q62862) Dual specificity mitogen-activated protein kinase
           kinase 5 (EC 2.7.1.-) (MAP kinase kinase 5) (MAPKK 5)
           (MAPK/ERK kinase 5)
          Length = 448

 Score =  155 bits (392), Expect = 2e-37
 Identities = 92/258 (35%), Positives = 146/258 (55%), Gaps = 14/258 (5%)

Query: 90  IGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDDVNVVKCHEMY 149
           +G G+GGTVYK  H  +G+  A+KVI       +++QI  E++IL   D   ++  +  +
Sbjct: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231

Query: 150 DHNAEIQVLLEYMDGGSLEGKHIPQENQLADVARQILRGLAYLHRRHIVHRDIKPSNLLI 209
                I +  E+MDGGSL+      E+ L  +A  +++GL YL    I+HRD+KPSN+L+
Sbjct: 232 FVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLV 291

Query: 210 NSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDINDGQYDAYAGDIWSLGV 269
           N+  QVK+ DFGV   L  ++    + VGT AYM+PERI+ +    QY  ++ D+WSLG+
Sbjct: 292 NTSGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAPERISGE----QYGIHS-DVWSLGI 344

Query: 270 SILEFYMGRFPF--AVGRQGDWASLMCAICMSQPPEAPTTASPEFRD----FVSRCLQRD 323
           S +E  +GRFP+      QG    L    C+    ++P     EF +    F+++C+++ 
Sbjct: 345 SFMELALGRFPYPQIQKNQGSLMPLQLLQCIVD-EDSPVLPLGEFSEPFVHFITQCMRKQ 403

Query: 324 PSRRWTASRLLSHPFLVR 341
           P  R     L+ HPF+V+
Sbjct: 404 PKERPAPEELMGHPFIVQ 421


>PBS2_YEAST (P08018) Polymyxin B resistance protein kinase (EC
           2.7.1.-)
          Length = 668

 Score =  153 bits (386), Expect = 8e-37
 Identities = 101/282 (35%), Positives = 154/282 (53%), Gaps = 14/282 (4%)

Query: 70  SGGASQQLVIPFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHR 129
           S G+S ++ +   ELE L+ +G G+ G V KV+H+      A K +    +E+  RQI  
Sbjct: 348 SNGSSSRITL--DELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILM 405

Query: 130 EIQILRDVDDVNVVKCHEMYDHNAEIQVLLEYMDGGSL-----EGKHIP--QENQLADVA 182
           E+++L   +   +V  +  +     + + +EYMDGGSL     E   I    E QLA +A
Sbjct: 406 ELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIA 465

Query: 183 RQILRGLAYLHRRH-IVHRDIKPSNLLINSRK-QVKIADFGVGRILNQTMDPCNSSVGTI 240
             ++ GL  L  +H I+HRD+KP+N+L ++ +  VK+ DFGV    N       +++G  
Sbjct: 466 NAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSG--NLVASLAKTNIGCQ 523

Query: 241 AYMSPERINTDINDGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQ 300
           +YM+PERI +   D        DIWSLG+SILE  +GR+P+      +  S + AI    
Sbjct: 524 SYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGP 583

Query: 301 PPEAPTTA-SPEFRDFVSRCLQRDPSRRWTASRLLSHPFLVR 341
           PP  P+   S + +DFVS CLQ+ P RR T + L  HP+LV+
Sbjct: 584 PPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVK 625


>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1.37)
           (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like
           protein kinase 1) (Serine/threonine-protein kinase
           Krs-2)
          Length = 487

 Score =  151 bits (382), Expect = 2e-36
 Identities = 98/271 (36%), Positives = 148/271 (54%), Gaps = 26/271 (9%)

Query: 80  PFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDD 139
           P    + L ++G GS G+VYK +H+  G+  A+K +     ES  ++I +EI I++  D 
Sbjct: 26  PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDS 82

Query: 140 VNVVKCHEMYDHNAEIQVLLEYMDGGS------LEGKHIPQENQLADVARQILRGLAYLH 193
            +VVK +  Y  N ++ +++EY   GS      L  K +  E+++A + +  L+GL YLH
Sbjct: 83  PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 141

Query: 194 RRHIVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDIN 253
               +HRDIK  N+L+N+    K+ADFGV   L  TM   N+ +GT  +M+PE     I 
Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE----VIQ 197

Query: 254 DGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQPPEAPTTASPE-- 311
           +  Y+  A DIWSLG++ +E   G+ P+A          M AI M      PT   PE  
Sbjct: 198 EIGYNCVA-DIWSLGITAIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELW 250

Query: 312 ---FRDFVSRCLQRDPSRRWTASRLLSHPFL 339
              F DFV +CL + P +R TA++LL HPF+
Sbjct: 251 SDNFTDFVKQCLVKSPEQRATATQLLQHPFV 281


>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC
           2.7.1.-)
          Length = 435

 Score =  151 bits (382), Expect = 2e-36
 Identities = 91/223 (40%), Positives = 135/223 (59%), Gaps = 14/223 (6%)

Query: 72  GASQQLVIPFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREI 131
           G   +L +   +L+ L+ +G+G+GGTV KV+H  +G   A KV++   + SVR+QI RE+
Sbjct: 97  GVEYKLDLKNEDLKTLSELGAGNGGTVTKVLHEKSGTVMAKKVVFIDAKPSVRKQILREL 156

Query: 132 QILRDVDDVNVVKCHEMYDHNAEIQVLLEYMDGGSLEG---KHIPQENQL-ADVARQILR 187
           QIL + +   +V  +  Y +   I + +E+M   SL+G   K+ P   ++   +A  +  
Sbjct: 157 QILHECNSPYIVSFYGAYLNEPHICMCMEFMQKDSLDGIYKKYGPISPEICGKIAVAVSH 216

Query: 188 GLAYLHRRH-IVHRDIKPSNLLINSRKQVKIADFGV-GRILNQTMDPCNSSVGTIAYMSP 245
           GL YL+  H I+HRD+KPSN+L+N   Q+KI DFGV G ++N   D   + VGT  YMSP
Sbjct: 217 GLTYLYDVHRIIHRDVKPSNILVNGAGQIKICDFGVSGELINSIAD---TFVGTSTYMSP 273

Query: 246 ERINTDINDGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGD 288
           ERI  D    QY +   D+WSLGVSI++  +GRFPFA   + D
Sbjct: 274 ERIQGD----QY-SVKSDVWSLGVSIIDVALGRFPFAENEEDD 311


>ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC
           2.7.1.37) (STE20-like kinase MST3) (MST-3) (Mammalian
           STE20-like protein kinase 3)
          Length = 443

 Score =  151 bits (381), Expect = 3e-36
 Identities = 95/275 (34%), Positives = 143/275 (51%), Gaps = 11/275 (4%)

Query: 71  GGASQQLVIPFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHRE 130
           GG++     P     +L +IG GS G V+K +     +  A+K+I     E     I +E
Sbjct: 23  GGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 82

Query: 131 IQILRDVDDVNVVKCHEMYDHNAEIQVLLEYMDGGSLEGKHIP---QENQLADVARQILR 187
           I +L   D   V K +  Y  + ++ +++EY+ GGS      P    E Q+A + R+IL+
Sbjct: 83  ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILK 142

Query: 188 GLAYLHRRHIVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPER 247
           GL YLH    +HRDIK +N+L++   +VK+ADFGV   L  T    N+ VGT  +M+PE 
Sbjct: 143 GLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE- 201

Query: 248 INTDINDGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQPPEAPTT 307
               I    YD+ A DIWSLG++ +E   G  P +   +     ++  I  + PP     
Sbjct: 202 ---VIKQSAYDSKA-DIWSLGITAIELARGEPPHS---ELHPMKVLFLIPKNNPPTLEGN 254

Query: 308 ASPEFRDFVSRCLQRDPSRRWTASRLLSHPFLVRN 342
            S   ++FV  CL ++PS R TA  LL H F++RN
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 289


>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
           (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
           protein kinase 2)
          Length = 497

 Score =  150 bits (379), Expect = 5e-36
 Identities = 97/271 (35%), Positives = 148/271 (53%), Gaps = 26/271 (9%)

Query: 80  PFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDD 139
           P    + L ++G GS G+V+K +H+ +G+  A+K +     ES  ++I +EI I++  D 
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV---PVESDLQEIIKEISIMQQCDS 79

Query: 140 VNVVKCHEMYDHNAEIQVLLEYMDGGS------LEGKHIPQENQLADVARQILRGLAYLH 193
             VVK +  Y  N ++ +++EY   GS      L  K +  E+++A + +  L+GL YLH
Sbjct: 80  PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILKSTLKGLEYLH 138

Query: 194 RRHIVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDIN 253
               +HRDIK  N+L+N+    K+ADFGV   L  TM   N+ +GT  +M+PE     I 
Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE----VIQ 194

Query: 254 DGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQPPEAPTTASPE-- 311
           +  Y+  A DIWSLG++ +E   G+ P+A          M AI M      PT   PE  
Sbjct: 195 EIGYNCVA-DIWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELW 247

Query: 312 ---FRDFVSRCLQRDPSRRWTASRLLSHPFL 339
              F DFV +CL + P +R TA++LL HPF+
Sbjct: 248 SDDFTDFVKKCLVKSPEQRATATQLLQHPFI 278


>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
           (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
           protein kinase 2) (Serine/threonine-protein kinase
           Krs-1)
          Length = 491

 Score =  150 bits (378), Expect = 6e-36
 Identities = 97/271 (35%), Positives = 149/271 (54%), Gaps = 26/271 (9%)

Query: 80  PFSELERLNRIGSGSGGTVYKVVHRINGRAYALKVIYGHHEESVRRQIHREIQILRDVDD 139
           P    + L ++G GS G+V+K +H+ +G+  A+K +     ES  ++I +EI I++  D 
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV---PVESDLQEIIKEISIMQQCDS 79

Query: 140 VNVVKCHEMYDHNAEIQVLLEYMDGGS------LEGKHIPQENQLADVARQILRGLAYLH 193
             VVK +  Y  N ++ +++EY   GS      L  K +  E+++A + +  L+GL YLH
Sbjct: 80  PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLI-EDEIATILKSTLKGLEYLH 138

Query: 194 RRHIVHRDIKPSNLLINSRKQVKIADFGVGRILNQTMDPCNSSVGTIAYMSPERINTDIN 253
               +HRDIK  N+L+N+    K+ADFGV   L  TM   N+ +GT  +M+PE     I 
Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE----VIQ 194

Query: 254 DGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQGDWASLMCAICMSQPPEAPTTASPE-- 311
           +  Y+  A DIWSLG++ +E   G+ P+A          M AI M      PT   PE  
Sbjct: 195 EIGYNCVA-DIWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELW 247

Query: 312 ---FRDFVSRCLQRDPSRRWTASRLLSHPFL 339
              F DFV +CL ++P +R TA++LL HPF+
Sbjct: 248 SDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278


>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.1.-)
          Length = 508

 Score =  149 bits (376), Expect = 1e-35
 Identities = 94/276 (34%), Positives = 151/276 (54%), Gaps = 28/276 (10%)

Query: 84  LERLNRIGSGSGGTVYKVVHRINGRAYALKVIYG-HHEESVRRQIHREIQILRDVDDVNV 142
           +E L  +G G+GG+V K   +   + +ALKVI   + +   ++QI RE+Q  R      +
Sbjct: 221 IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYI 280

Query: 143 VKCHEMY--DHNAEIQVLLEYMDGGSLEG--KHIPQ------ENQLADVARQILRGLAYL 192
           V+ + M+  D N+ I + +EYM G SL+   K++ +      E  L  +A  +LRGL+YL
Sbjct: 281 VRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYL 340

Query: 193 HRRHIVHRDIKPSNLLINSRKQVKIADFGV-GRILNQTMDPCNSSVGTIAYMSPERINTD 251
           H + ++HRDIKP N+L+N   QVK+ DFGV G  +N       +  GT  YM+PERI   
Sbjct: 341 HEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSL---ATTFTGTSFYMAPERI--- 394

Query: 252 INDGQYDAYAGDIWSLGVSILEFYMGRFPFAVGRQ----GDWASLMCAIC----MSQPPE 303
              GQ  +   D+WSLG++ILE   G+FP +  +       +  LM  +     +   PE
Sbjct: 395 --QGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPE 452

Query: 304 APTTASPEFRDFVSRCLQRDPSRRWTASRLLSHPFL 339
           +    SP F+ F+  CL++D   R +  ++++HP++
Sbjct: 453 SNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWI 488


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.318    0.136    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,764,288
Number of Sequences: 164201
Number of extensions: 2339221
Number of successful extensions: 30419
Number of sequences better than 10.0: 1954
Number of HSP's better than 10.0 without gapping: 1715
Number of HSP's successfully gapped in prelim test: 246
Number of HSP's that attempted gapping in prelim test: 19749
Number of HSP's gapped (non-prelim): 5306
length of query: 366
length of database: 59,974,054
effective HSP length: 112
effective length of query: 254
effective length of database: 41,583,542
effective search space: 10562219668
effective search space used: 10562219668
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)