BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144503.1 + phase: 0 /pseudo
(718 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
SPAK_RAT (O88506) STE20/SPS1-related proline-alanine rich protei... 305 3e-82
SPAK_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine rich prot... 305 3e-82
SPAK_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine rich prot... 305 3e-82
ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.1... 228 4e-59
ST25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.1... 226 2e-58
ST25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.1... 223 1e-57
STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1.... 205 3e-52
SPS1_YEAST (P08458) Sporulation-specific protein 1 (EC 2.7.1.-) 202 2e-51
STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1.... 201 6e-51
STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1.... 201 6e-51
SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7... 199 3e-50
NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC 2.7... 194 5e-49
HPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7... 190 1e-47
TNIK_HUMAN (Q9UKE5) TRAF2 and NCK interacting kinase (EC 2.7.1.37) 181 6e-45
M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kina... 180 1e-44
TNIK_MOUSE (P83510) Traf2 and NCK interacting kinase (EC 2.7.1.3... 178 4e-44
M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kina... 177 7e-44
M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kina... 177 9e-44
M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase... 176 3e-43
KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC 2.7... 175 3e-43
>SPAK_RAT (O88506) STE20/SPS1-related proline-alanine rich protein
kinase (EC 2.7.1.37) (Ste-20 related kinase)
(Serine/threonine-protein kinase 39) (Pancreatic
serine/threonine kinase) (PS/TK) (PSTK1)
Length = 553
Score = 305 bits (781), Expect = 3e-82
Identities = 157/311 (50%), Positives = 214/311 (68%), Gaps = 13/311 (4%)
Query: 17 YPIGAEHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVL 76
+PI + Y+L E IG G +A V ALC E VAIK ++ E+ ++ + +E Q M
Sbjct: 65 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 124
Query: 77 VDHPNVLKSHCSFVSDHNLWVVMPFMSGGSCLHILK-----AAHPDG-FEEVVIATVLRE 130
HPNV+ + SFV LW+VM +SGGS L I+K H +G EE +IAT+L+E
Sbjct: 125 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 184
Query: 131 VLKGLEYLHHHGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGD--RQRSRNTFVGT 188
VL+GL+YLH +G IHRD+KAGN+L+ G+V++ DFGVSA L GD R + R TFVGT
Sbjct: 185 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGT 244
Query: 189 PCWMAPEVMEQLHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGL-- 246
PCWMAPEVMEQ+ GY+FKAD+WSFGITA+ELA G AP+ KYPP+KVL++TLQN PP L
Sbjct: 245 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLET 304
Query: 247 ---DYERDKKFSKSFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLP 303
D E KK+ KSF+++++ CL KDPSKRP+A++LLK FF++A++ +Y+ LL P
Sbjct: 305 GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTP 364
Query: 304 ALGDRMEILKR 314
+ R + ++R
Sbjct: 365 DIAQRAKKVRR 375
>SPAK_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine rich protein
kinase (EC 2.7.1.37) (Ste-20 related kinase)
(Serine/threonine-protein kinase 39)
Length = 556
Score = 305 bits (781), Expect = 3e-82
Identities = 157/311 (50%), Positives = 214/311 (68%), Gaps = 13/311 (4%)
Query: 17 YPIGAEHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVL 76
+PI + Y+L E IG G +A V ALC E VAIK ++ E+ ++ + +E Q M
Sbjct: 68 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 127
Query: 77 VDHPNVLKSHCSFVSDHNLWVVMPFMSGGSCLHILK-----AAHPDG-FEEVVIATVLRE 130
HPNV+ + SFV LW+VM +SGGS L I+K H +G EE +IAT+L+E
Sbjct: 128 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 187
Query: 131 VLKGLEYLHHHGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGD--RQRSRNTFVGT 188
VL+GL+YLH +G IHRD+KAGN+L+ G+V++ DFGVSA L GD R + R TFVGT
Sbjct: 188 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGT 247
Query: 189 PCWMAPEVMEQLHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGL-- 246
PCWMAPEVMEQ+ GY+FKAD+WSFGITA+ELA G AP+ KYPP+KVL++TLQN PP L
Sbjct: 248 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLET 307
Query: 247 ---DYERDKKFSKSFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLP 303
D E KK+ KSF+++++ CL KDPSKRP+A++LLK FF++A++ +Y+ LL P
Sbjct: 308 GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTP 367
Query: 304 ALGDRMEILKR 314
+ R + ++R
Sbjct: 368 DIAQRAKKVRR 378
>SPAK_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine rich protein
kinase (EC 2.7.1.37) (Ste-20 related kinase)
(Serine/threonine-protein kinase 39) (DCHT)
Length = 547
Score = 305 bits (781), Expect = 3e-82
Identities = 157/311 (50%), Positives = 214/311 (68%), Gaps = 13/311 (4%)
Query: 17 YPIGAEHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVL 76
+PI + Y+L E IG G +A V ALC E VAIK ++ E+ ++ + +E Q M
Sbjct: 58 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 117
Query: 77 VDHPNVLKSHCSFVSDHNLWVVMPFMSGGSCLHILK-----AAHPDG-FEEVVIATVLRE 130
HPNV+ + SFV LW+VM +SGGS L I+K H +G EE +IAT+L+E
Sbjct: 118 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 177
Query: 131 VLKGLEYLHHHGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGD--RQRSRNTFVGT 188
VL+GL+YLH +G IHRD+KAGN+L+ G+V++ DFGVSA L GD R + R TFVGT
Sbjct: 178 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGT 237
Query: 189 PCWMAPEVMEQLHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGL-- 246
PCWMAPEVMEQ+ GY+FKAD+WSFGITA+ELA G AP+ KYPP+KVL++TLQN PP L
Sbjct: 238 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLET 297
Query: 247 ---DYERDKKFSKSFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLP 303
D E KK+ KSF+++++ CL KDPSKRP+A++LLK FF++A++ +Y+ LL P
Sbjct: 298 GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTP 357
Query: 304 ALGDRMEILKR 314
+ R + ++R
Sbjct: 358 DIAQRAKKVRR 368
>ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC
2.7.1.37) (STE20-like kinase MST3) (MST-3) (Mammalian
STE20-like protein kinase 3)
Length = 443
Score = 228 bits (581), Expect = 4e-59
Identities = 123/278 (44%), Positives = 173/278 (61%), Gaps = 12/278 (4%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + E+IG+G V + + ++VAIKI+D E ++ +I +E + D P
Sbjct: 34 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 93
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V K + S++ D LW++M ++ GGS L +L+ P +E IAT+LRE+LKGL+YLH
Sbjct: 94 VTKYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDYLHSE 150
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KA NVL+ G VKL DFGV+ L D+ Q RNTFVGTP WMAPEV++Q
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQ-S 206
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
Y+ KADIWS GITA+ELA G P S+ P+KVL + +N PP L + +SK K+
Sbjct: 207 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL----EGNYSKPLKEF 262
Query: 262 IACCLVKDPSKRPSASKLLKHSF-FKQARSSDYITRTL 298
+ CL K+PS RP+A +LLKH F + A+ + Y+T +
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 300
>ST25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC
2.7.1.37) (Sterile 20/oxidant stress-response kinase 1)
(Ste20/oxidant stress response kinase-1) (SOK-1)
(Ste20-like kinase)
Length = 426
Score = 226 bits (576), Expect = 2e-58
Identities = 121/278 (43%), Positives = 172/278 (61%), Gaps = 12/278 (4%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + + IG+G V++ + E+VAIKI+D E ++ +I +E + D P
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
+ + S++ LW++M ++ GGS L +LK P EE IAT+LRE+LKGL+YLH
Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDYLHSE 134
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KA NVL+ +G VKL DFGV+ L D+ Q RNTFVGTP WMAPEV++Q
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQ-S 190
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
Y+FKADIWS GITA+ELA G P S P++VL + +N+PP L+ + SK FK+
Sbjct: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH----SKPFKEF 246
Query: 262 IACCLVKDPSKRPSASKLLKHSFF-KQARSSDYITRTL 298
+ CL KDP RP+A +LLKH F + + + ++T +
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELI 284
>ST25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC
2.7.1.37) (Sterile 20/oxidant stress-response kinase 1)
(Ste20/oxidant stress response kinase-1) (SOK-1)
(Ste20-like kinase)
Length = 426
Score = 223 bits (569), Expect = 1e-57
Identities = 120/278 (43%), Positives = 170/278 (60%), Gaps = 12/278 (4%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + + IG+G V++ + E+VAIKI+D E ++ +I +E + D P
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
+ + S++ LW++M ++ GGS L +LK P EE IAT+LRE+LKGL+YLH
Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDYLHSE 134
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KA NVL+ +G VK+ DFGV+ L D+ Q RNTFVGTP WMAPEV++Q
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKMADFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQ-S 190
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
Y+FKADIWS GITA+ELA G P S P++VL + +N PP L+ SK FK+
Sbjct: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHH----SKPFKEF 246
Query: 262 IACCLVKDPSKRPSASKLLKHSFF-KQARSSDYITRTL 298
+ CL KDP RP+A +LLKH F + + + ++T +
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELI 284
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1.37)
(STE20-like kinase MST1) (MST-1) (Mammalian STE20-like
protein kinase 1) (Serine/threonine-protein kinase
Krs-2)
Length = 487
Score = 205 bits (522), Expect = 3e-52
Identities = 114/309 (36%), Positives = 181/309 (57%), Gaps = 10/309 (3%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + + E++G+G SV++A+ +IVAIK + E D L I +E M D P+
Sbjct: 28 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---LQEIIKEISIMQQCDSPH 84
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V+K + S+ + +LW+VM + GS I++ + E+ IAT+L+ LKGLEYLH
Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDE-IATILQSTLKGLEYLHFM 143
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KAGN+L+++ G KL DFGV+ L D+ RNT +GTP WMAPEV++++
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIQEI- 199
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
GYN ADIWS GITA+E+A G P++ P++ + M N PP + + + +S +F
Sbjct: 200 GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPP--TFRKPELWSDNFTDF 257
Query: 262 IACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKRKEDMLAQ 321
+ CLVK P +R +A++LL+H F + A+ + + E + R E +R+ D +
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDE 317
Query: 322 KKMPDGQME 330
+ + +M+
Sbjct: 318 ENSEEDEMD 326
>SPS1_YEAST (P08458) Sporulation-specific protein 1 (EC 2.7.1.-)
Length = 490
Score = 202 bits (514), Expect = 2e-51
Identities = 134/409 (32%), Positives = 210/409 (50%), Gaps = 41/409 (10%)
Query: 24 YQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPNVL 83
Y + IG+G V++A+ EIVAIK+++ E + D+ +++E + + P +
Sbjct: 18 YSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLIT 77
Query: 84 KSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHHGH 143
+ + D ++W+VM + GGSC +LK ++ +G E ++ ++ EV GL+YLH
Sbjct: 78 NYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRK 137
Query: 144 IHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVM-EQLHG 202
IHRD+KA N+L++ G VKLGDFGVS + + R+TFVGTP WMAPEV+ ++ G
Sbjct: 138 IHRDIKAANILLNEEGMVKLGDFGVSGHIRST----LKRDTFVGTPYWMAPEVVCCEVDG 193
Query: 203 YNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQMI 262
YN KADIWS GIT EL G P SKY P+KV+ + PP L FS + K +
Sbjct: 194 YNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKL----QGPFSDAAKDFV 249
Query: 263 ACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKRKEDMLAQK 322
A CLVK P+ RPSA LL F K IT T L+ ++++K+K+
Sbjct: 250 AGCLVKTPADRPSAYNLLSFEFVKN------ITITNLK------SDVDLIKQKKVQERYT 297
Query: 323 KMPDGQMEE--LSQNEYKRGISGWNFNLEDMKAQASLINDFDDAMSDISHVSSACSLTNL 380
K+P ++ + RG WNF +++ ++ + ++S ++ ++L
Sbjct: 298 KVPKYPLQNRLYKNSNTVRGKEFWNF-------ESTRLSTTQISKEELSPITQDSPTSSL 350
Query: 381 DAQDKQL-----------PSSSHSRSQTADMSDDDSSITSSSHEPQTSS 418
+ + L PSSS R T + + DS + S P +
Sbjct: 351 NMESPYLLHGQTVTPITNPSSSSFRKCTQPVFELDSGMDIDSGCPNAQA 399
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
(STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
protein kinase 2)
Length = 497
Score = 201 bits (511), Expect = 6e-51
Identities = 126/394 (31%), Positives = 213/394 (53%), Gaps = 25/394 (6%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + + E++G+G SV +A+ ++VAIK + E D L I +E M D P
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDSPY 81
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V+K + S+ + +LW+VM + GS I++ + E+ IAT+L+ LKGLEYLH
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDE-IATILKSTLKGLEYLHFM 140
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KAGN+L+++ G KL DFGV+ L D+ RNT +GTP WMAPEV++++
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIQEI- 196
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
GYN ADIWS GIT++E+A G P++ P++ + M N PP + + + +S F
Sbjct: 197 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPP--TFRKPELWSDDFTDF 254
Query: 262 IACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKRKEDMLAQ 321
+ CLVK P +R +A++LL+H F K A+ + + E + R E +R+ +
Sbjct: 255 VKKCLVKSPEQRATATQLLQHPFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRE----LE 310
Query: 322 KKMPDGQMEELSQNEYKRGISGWNFNLEDMKAQASLINDFDDAMSDISHVSSACSLTNLD 381
++ + +EL + + S ++ M+A +++ + A + I H S T L+
Sbjct: 311 EEEENSDEDELDSHTMVKTSSE---SVGTMRATSTM---SEGAQTMIEHNS-----TMLE 359
Query: 382 AQDKQLPSSSHSRSQTADMSDDDSSITSSSHEPQ 415
+ + +S + + ++D ++ ++ PQ
Sbjct: 360 SDLGTMVINSEEEEEEEEEEEEDGTMKRNATSPQ 393
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
(STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
protein kinase 2) (Serine/threonine-protein kinase
Krs-1)
Length = 491
Score = 201 bits (511), Expect = 6e-51
Identities = 111/294 (37%), Positives = 172/294 (57%), Gaps = 10/294 (3%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E + + E++G+G SV +A+ ++VAIK + E D L I +E M D P
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDSPY 81
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V+K + S+ + +LW+VM + GS I++ + E+ IAT+L+ LKGLEYLH
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE-IATILKSTLKGLEYLHFM 140
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLH 201
IHRD+KAGN+L+++ G KL DFGV+ L D+ RNT +GTP WMAPEV++++
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIQEI- 196
Query: 202 GYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQM 261
GYN ADIWS GIT++E+A G P++ P++ + M N PP + + + +S F
Sbjct: 197 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPP--TFRKPELWSDDFTDF 254
Query: 262 IACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKRK 315
+ CLVK+P +R +A++LL+H F K A+ + + E + R E +R+
Sbjct: 255 VKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE 308
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC
2.7.1.37) (STE20-like kinase sid1)
Length = 471
Score = 199 bits (505), Expect = 3e-50
Identities = 115/273 (42%), Positives = 161/273 (58%), Gaps = 12/273 (4%)
Query: 17 YPIGAEHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVL 76
YP+ A Y L ++G G V +A +I+AIK +D E D+ +I +E +
Sbjct: 2 YPLNANSYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSN 61
Query: 77 VDHPNVLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLE 136
+ NV++ + FV + LW++M M GGS +LK E VI+ +LREVL GL
Sbjct: 62 CNSSNVIQYYGCFVDGYTLWILMEHMDGGSVSGLLKMGR---LNEQVISIILREVLYGLN 118
Query: 137 YLHHHGHIHRDVKAGNVLI-DSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPE 195
YLH IHRD+KA N+L+ S G VKL DFGV+A L ++ R R+TFVGTP WMAPE
Sbjct: 119 YLHGQNKIHRDIKAANILLSSSTGNVKLADFGVAAQLSNAASR---RHTFVGTPFWMAPE 175
Query: 196 VMEQLHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFS 255
V++Q Y ADIWS GITA+E+A+G P + P++V+ Q+ PP L D FS
Sbjct: 176 VIQQT-SYGLAADIWSLGITAIEMANGIPPRATMHPMRVIFEIPQSEPPKL----DDHFS 230
Query: 256 KSFKQMIACCLVKDPSKRPSASKLLKHSFFKQA 288
+F+ ++CCL +P+ R SA +LL+H F K A
Sbjct: 231 PTFRDFVSCCLDLNPNMRWSAKELLQHPFIKSA 263
>NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC
2.7.1.37) (N-rich kinase 1)
Length = 652
Score = 194 bits (494), Expect = 5e-49
Identities = 130/398 (32%), Positives = 206/398 (51%), Gaps = 33/398 (8%)
Query: 24 YQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLV---DHP 80
Y E +G+G +V+R +C E VAIKIL+ + D ++++I +E + + D
Sbjct: 10 YTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVE 69
Query: 81 NVLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHH 140
N++K H S++ NLW++M + GGS +++A E I+ +LRE L+ L+++HH
Sbjct: 70 NIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGP---ISEPCISLILRETLQALKFIHH 126
Query: 141 HGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQL 200
G IHRD+KA N+L+ G VKL DFGV+A L +R R TF+GTP WMAPEV+
Sbjct: 127 AGIIHRDIKAANILVSMSGNVKLCDFGVAAEL---NINRRKRITFIGTPYWMAPEVIRDG 183
Query: 201 HGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQ 260
YN ADIWS GITA E+A G P +K P + + + APP L + FS K+
Sbjct: 184 QEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRL----NGNFSALLKE 239
Query: 261 MIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKR----KE 316
IA CL P +R +S+LLK F KQ +R + L + R + + +
Sbjct: 240 FIASCLQDVPQRRLDSSELLKSKFIKQ------YSRMSISELTNVVKRYDTWQAAGGIPQ 293
Query: 317 DMLAQKKMPDGQMEELSQNEYKRGISGWNFNLEDMKAQASLINDFDDAMSDISHVSSACS 376
+L ++ DG + ++ GW F + Q+++ + + S + +S+ +
Sbjct: 294 TLLLGEEADDGSDPDQETSDTAASDDGWEFG-TIKQGQSNVSSITGTSTSTTTAATSSTT 352
Query: 377 LTNL----DAQDKQLPSSSHSRS-----QTADMSDDDS 405
+T + + PSS+ S + + +SDDDS
Sbjct: 353 VTGTVIPKSSTVHEPPSSNDSHPLLQLFKDSKISDDDS 390
>HPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC
2.7.1.37)
Length = 669
Score = 190 bits (483), Expect = 1e-47
Identities = 110/320 (34%), Positives = 180/320 (55%), Gaps = 17/320 (5%)
Query: 24 YQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPNVL 83
+ + ++G+G SV++A+ + IVAIK++ E D L+ I +E M D P V+
Sbjct: 42 FDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESD---LHEIIKEISIMQQCDSPYVV 98
Query: 84 KSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHHGH 143
+ + S+ ++LW+ M + GS I++ E+ IAT+L + L+GL YLH
Sbjct: 99 RYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDE-IATILSDTLQGLVYLHLRRK 157
Query: 144 IHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLHGY 203
IHRD+KA N+L+++ G KL DFGV+ L D+ RNT +GTP WMAPEV+E++ GY
Sbjct: 158 IHRDIKAANILLNTEGYAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIEEI-GY 213
Query: 204 NFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQMIA 263
+ ADIWS GITALE+A G P+ + P++ + M Q PP + ++S F ++
Sbjct: 214 DCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPP--SFREPDRWSTEFIDFVS 271
Query: 264 CCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEILKRKEDMLAQKK 323
CLVK+P R +A++LL+H F + A+ I + +LE A+ ++ + +LA +
Sbjct: 272 KCLVKEPDDRATATELLEHEFIRNAKHRS-ILKPMLEETCAIREQQRANRSFGGVLAASQ 330
Query: 324 ------MPDGQMEELSQNEY 337
+G + ++ N +
Sbjct: 331 AKSLATQENGMQQHITDNAF 350
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK interacting kinase (EC 2.7.1.37)
Length = 1360
Score = 181 bits (459), Expect = 6e-45
Identities = 122/387 (31%), Positives = 197/387 (50%), Gaps = 32/387 (8%)
Query: 24 YQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHP-NV 82
++L E +G G V++ V ++ AIK++D D + I +E + H N+
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD--EEEEIKQEINMLKKYSHHRNI 82
Query: 83 LKSHCSFVS------DHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLE 136
+ +F+ D LW+VM F GS ++K + +E IA + RE+L+GL
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 137 YLHHHGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV 196
+LH H IHRD+K NVL+ VKL DFGVSA L + R RNTF+GTP WMAPEV
Sbjct: 143 HLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR---RNTFIGTPYWMAPEV 199
Query: 197 MEQLHG----YNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDK 252
+ Y+FK+D+WS GITA+E+A G P P++ L + +N P L + K
Sbjct: 200 IACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL---KSK 256
Query: 253 KFSKSFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTLLEGLPALGDRMEIL 312
K+SK F+ I CLVK+ S+RP+ +L+KH F + + + L + + DR +
Sbjct: 257 KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHI----DRTKKK 312
Query: 313 KRKEDMLAQKKMPDGQMEELSQNEYKRGISGWNFNLEDMKAQASLINDFDDAMSDISHVS 372
+ ++D + G EE +N+ SG ++ ++ +++L DF +++
Sbjct: 313 RGEKDETEYEY--SGSEEEEEEND-----SGEPSSILNLPGESTLRRDF--LRLQLANKE 363
Query: 373 SACSLTNLDAQDKQLPSSSHSRSQTAD 399
+ +L + +Q + H R A+
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAE 390
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase
kinase 3 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 3)
(MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase
related protein kinase) (GLK)
Length = 894
Score = 180 bits (456), Expect = 1e-44
Identities = 114/282 (40%), Positives = 158/282 (55%), Gaps = 19/282 (6%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E ++L + IG G V++A V+ E+ AIK++ E D + +E M HPN
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGE-DFAVVQQEIIMMKDCKHPN 72
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
++ S++ LW+ M F GGS I P E+ IA V RE L+GL YLH
Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYYLHSK 130
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV--MEQ 199
G +HRD+K N+L+ G VKL DFGVSA + + +++S F+GTP WMAPEV +E+
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKS---FIGTPYWMAPEVAAVER 187
Query: 200 LHGYNFKADIWSFGITALELAHGHAP-FSKYPPLKVLLMTLQN-APPGLDYERDK-KFSK 256
GYN D+W+ GITA+ELA P F +P + LMT N PP L +DK K+S
Sbjct: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL---KDKMKWSN 244
Query: 257 SFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTL 298
SF + L K+P KRP+A KLL+H F Q ++TR+L
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ-----HLTRSL 281
>TNIK_MOUSE (P83510) Traf2 and NCK interacting kinase (EC 2.7.1.37)
(Fragments)
Length = 916
Score = 178 bits (452), Expect = 4e-44
Identities = 108/293 (36%), Positives = 159/293 (53%), Gaps = 27/293 (9%)
Query: 24 YQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHP-NV 82
++L E +G G V++ V ++ AIK++D D + I +E + H N+
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD--EEEEIKQEINMLKKYSHHRNI 82
Query: 83 LKSHCSFVS------DHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLE 136
+ +F+ D LW+VM F GS ++K + +E IA + RE+L+GL
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 137 YLHHHGHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV 196
+LH H IHRD+K NVL+ VKL DFGVSA L + R RNTF+GTP WMAPEV
Sbjct: 143 HLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR---RNTFIGTPYWMAPEV 199
Query: 197 MEQLHG----YNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDK 252
+ Y+FK+D+WS GITA+E+A G P P++ L + +N P L + K
Sbjct: 200 IACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL---KSK 256
Query: 253 KFSKSFKQMIACCLVKDPSKRPSASKLLKHSFFK--------QARSSDYITRT 297
K+SK F+ I CLVK+ S+RP+ +L+KH F + + + D+I RT
Sbjct: 257 KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRT 309
>M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kinase
kinase 2 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 2)
(MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase)
(GC kinase) (Rab8 interacting protein) (B lymphocyte
serine/threonine-pro
Length = 819
Score = 177 bits (450), Expect = 7e-44
Identities = 107/282 (37%), Positives = 162/282 (56%), Gaps = 14/282 (4%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
+ ++L + +G G V++A +E+ A+KI+ + + D++++ +E + HPN
Sbjct: 13 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGD-DISSLQQEITILRECRHPN 71
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V+ S++ + LW+ M F GGS I A P EE IA V RE LKGL +LH
Sbjct: 72 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP--LEERQIAYVCRERLKGLHHLHSQ 129
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV--MEQ 199
G IHRD+K N+L+ +G VKL DFGVS L S ++RS F+GTP WMAPEV +E+
Sbjct: 130 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRS---FIGTPYWMAPEVAAVER 186
Query: 200 LHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNA--PPGLDYERDK-KFSK 256
GYN D+W+ GITA+EL P P++ L++ +++ PP L RDK ++++
Sbjct: 187 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL---RDKTRWTQ 243
Query: 257 SFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTL 298
+F + L K+P KRP+A KLL+H F Q +T+ L
Sbjct: 244 NFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 285
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase
kinase 2 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 2)
(MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase)
(GCK) (Rab8 interacting protein)
Length = 821
Score = 177 bits (449), Expect = 9e-44
Identities = 106/282 (37%), Positives = 162/282 (56%), Gaps = 14/282 (4%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
+ ++L + +G G V++A +E+ A+KI+ + + D++++ +E + HPN
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGD-DISSLQQEITILRECRHPN 72
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
V+ S++ + LW+ M F GGS I A P EE IA V RE LKGL +LH
Sbjct: 73 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP--LEERQIAYVCREALKGLHHLHSQ 130
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV--MEQ 199
G IHRD+K N+L+ +G VKL DFGVS L S ++RS F+GTP WMAPEV +E+
Sbjct: 131 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRS---FIGTPYWMAPEVAAVER 187
Query: 200 LHGYNFKADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNA--PPGLDYERDK-KFSK 256
GYN D+W+ GITA+EL P P++ L++ +++ PP L RDK ++++
Sbjct: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL---RDKTRWTQ 244
Query: 257 SFKQMIACCLVKDPSKRPSASKLLKHSFFKQARSSDYITRTL 298
+F + L K+P KRP+A +LL+H F Q +T+ L
Sbjct: 245 NFHHFLKLALTKNPKKRPTAERLLQHPFTTQHLPPALLTQLL 286
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase
kinase 3 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 3)
(MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase
related protein kinase) (GLK) (Fragment)
Length = 862
Score = 176 bits (445), Expect = 3e-43
Identities = 110/271 (40%), Positives = 151/271 (55%), Gaps = 14/271 (5%)
Query: 22 EHYQLYEEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMVLVDHPN 81
E ++L + IG G V++A V+ E+ AIK++ E D + +E M H N
Sbjct: 3 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGE-DFAVVQQEIIMMKDCKHAN 61
Query: 82 VLKSHCSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHH 141
++ S++ LW+ M F GGS I P E+ IA V RE L+GL YLH
Sbjct: 62 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYYLHSK 119
Query: 142 GHIHRDVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEV--MEQ 199
G +HRD+K N+L+ G VKL DFGVSA + + +++S F+GTP WMAPEV +E+
Sbjct: 120 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKS---FIGTPYWMAPEVAAVER 176
Query: 200 LHGYNFKADIWSFGITALELAHGHAP-FSKYPPLKVLLMTLQN-APPGLDYERDK-KFSK 256
GYN D+W+ GITA+ELA P F +P + LMT N PP L +DK K+S
Sbjct: 177 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL---KDKLKWSN 233
Query: 257 SFKQMIACCLVKDPSKRPSASKLLKHSFFKQ 287
SF + L K+P KRP+A KLL+H F Q
Sbjct: 234 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 264
>KIC1_YEAST (P38692) Serine/threonine-protein kinase KIC1 (EC
2.7.1.37) (Kinase that interacts with CDC31) (N-rich
kinase 1)
Length = 1080
Score = 175 bits (444), Expect = 3e-43
Identities = 98/265 (36%), Positives = 155/265 (57%), Gaps = 10/265 (3%)
Query: 28 EEIGQGVSASVHRALCVSFNEIVAIKILDFERDNCDLNNISREAQTMV-LVDHPNVLKSH 86
E IG+G V++ V + AIK+L+ + D+ ++ ++ RE Q + L N+ + +
Sbjct: 27 EVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYY 86
Query: 87 CSFVSDHNLWVVMPFMSGGSCLHILKAAHPDGFEEVVIATVLREVLKGLEYLHHHGHIHR 146
S++ D +LW++M +GGS +L+ P +E I ++RE+L L+ +H IHR
Sbjct: 87 GSYLKDTSLWIIMEHCAGGSLRSLLR---PGKIDEKYIGVIMRELLVALKCIHKDNVIHR 143
Query: 147 DVKAGNVLIDSRGAVKLGDFGVSACLFDSGDRQRSRNTFVGTPCWMAPEVMEQLHGYNFK 206
D+KA NVLI + G VKL DFGV+A + + R R T GTP WMAPEV+ + Y+ K
Sbjct: 144 DIKAANVLITNEGNVKLCDFGVAAQVNQTSLR---RQTMAGTPYWMAPEVIMEGVYYDTK 200
Query: 207 ADIWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAPPGLDYERDKKFSKSFKQMIACCL 266
DIWS GIT E+A G+ P+ L+ + + +++ PP L+ D+ +S S K+ IA CL
Sbjct: 201 VDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLE---DRSYSTSLKEFIALCL 257
Query: 267 VKDPSKRPSASKLLKHSFFKQARSS 291
+DP +R SA LLK F + +++
Sbjct: 258 DEDPKERLSADDLLKSKFIRAHKAT 282
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,850,985
Number of Sequences: 164201
Number of extensions: 3504957
Number of successful extensions: 16720
Number of sequences better than 10.0: 1698
Number of HSP's better than 10.0 without gapping: 1387
Number of HSP's successfully gapped in prelim test: 312
Number of HSP's that attempted gapping in prelim test: 11364
Number of HSP's gapped (non-prelim): 2235
length of query: 718
length of database: 59,974,054
effective HSP length: 118
effective length of query: 600
effective length of database: 40,598,336
effective search space: 24359001600
effective search space used: 24359001600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Medicago: description of AC144503.1