BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144478.12 + phase: 0 /pseudo
(1250 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 929 0.0
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 927 0.0
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 923 0.0
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 904 0.0
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 904 0.0
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 893 0.0
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 890 0.0
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 885 0.0
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 882 0.0
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 880 0.0
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 818 0.0
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 817 0.0
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 814 0.0
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 792 0.0
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 773 0.0
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 730 0.0
PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1 725 0.0
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 686 0.0
MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprote... 655 0.0
MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprote... 619 e-176
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein 1)
(CD243 antigen)
Length = 1280
Score = 929 bits (2401), Expect = 0.0
Identities = 517/1295 (39%), Positives = 764/1295 (58%), Gaps = 112/1295 (8%)
Query: 22 RDNKTKQK-VPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSS-N 79
+D K K+ V + +F +++ LD M++GT++A+ +G PLM L G + + F ++ N
Sbjct: 25 KDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGN 84
Query: 80 PADAIKQVSKVSLL-----------------FVYLAIGSGI--ASFLQVTCWMVTGERQA 120
D + ++ S + + Y IG+G+ A+++QV+ W + RQ
Sbjct: 85 LEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQI 144
Query: 121 ARIRSLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGG 180
+IR + I++Q+I +FD + GE+ R++ D I E +G+K+G FFQ + F G
Sbjct: 145 HKIRKQFFHAIMRQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 181 FVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRT 240
F++ F +GW+L +V+LA P + ++ A + +++ + + +AYA+AG V ++ + AIRT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 241 VASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIE 300
V +F G+KK +E+YN ++ A +K+ I + IG + + +Y LA WYG+ LV+
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 301 KGYNGGTVMTVIIALMTGGI---------------------------------------- 320
Y+ G V+TV +++ G
Sbjct: 324 GEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 383
Query: 321 ----IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERF 376
IKG++E R+V F YP+R +V+I G +L V SG T ALVG SG GKST + L++R
Sbjct: 384 KPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 443
Query: 377 YDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTA 436
YDP G V +DG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +EI A
Sbjct: 444 YDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 503
Query: 437 ITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDA 496
+ ANA FI KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD
Sbjct: 504 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 563
Query: 497 ESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAY 556
ESE +VQ AL+K RTT+V+AHRL+T+RNAD+IA G IVE+G H L M G Y
Sbjct: 564 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL-MKEKGIY 622
Query: 557 SQLIRLQEGDNEAEGSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQ 616
+L+ +Q NE E ++ K ID+ S+ R+S +R S SV +Q
Sbjct: 623 FKLVTMQTAGNEVELENAADESKS----EIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQ 678
Query: 617 SLRGLSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIF 676
+ + E ++ I P VS WR+ KLN E P ++G AI+NG + P F
Sbjct: 679 DRKLSTKEALDESI----------PPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAF 728
Query: 677 GFLFSAVISMFYK--PPEQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERI 734
+FS +I +F + PE +R+ S +SLLF+ LG+++ + LQ F FG AG L +R+
Sbjct: 729 AIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRL 788
Query: 735 RSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSID 794
R + F ++ Q++SWFDDP ++ +GA+ RL+ D
Sbjct: 789 RYMVFRSMLRQDVSWFDDPKNT---------------------------TGALTTRLAND 821
Query: 795 ASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKG 854
A+ VK +G +A+I QNI+ + G++I+F W L ++L + P+I + G+V+MK L G
Sbjct: 822 AAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSG 881
Query: 855 FSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIG 914
+ K E A ++A +A+ + RTV S E K MY++ P + +R + GI
Sbjct: 882 QALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
Query: 915 FGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKA 974
F + ++Y + A F G+ LV H +F +V VF A+ A+AV Q ++ APD KA
Sbjct: 942 FSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKA 1001
Query: 975 KDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIP 1034
K SAA I II+ P IDS S G+ T+ G++ V FNYPTRPDI + + LSL +
Sbjct: 1002 KISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVK 1061
Query: 1035 SAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPI 1094
+T+ALVG SG GKSTV+ LLERFYDP +G++LLDG ++K + WLR +G+V QEPI
Sbjct: 1062 KGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPI 1121
Query: 1095 LFNESIRANIGYGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQK 1153
LF+ SI NI YG +++EI+ AA AN H+FI +LP+ Y T VG++GTQLSGGQK
Sbjct: 1122 LFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQK 1181
Query: 1154 QRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGAD 1213
QRIAIAR +++ P ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD
Sbjct: 1182 QRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNAD 1241
Query: 1214 TIAVIKNGAVAEKGRHDELMRITDGVYASLVALHS 1248
I V +NG V E G H +L+ G+Y S+V++ +
Sbjct: 1242 LIVVFQNGRVKEHGTHQQLL-AQKGIYFSMVSVQA 1275
Score = 418 bits (1075), Expect = e-116
Identities = 231/634 (36%), Positives = 363/634 (56%), Gaps = 53/634 (8%)
Query: 638 KKKPKVSIWRLAKL-NKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQQRK 696
+KKP VS++ + + N + +++G +AAI++G P+ +F + +F +
Sbjct: 29 EKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDL 88
Query: 697 ESRF---------------------WSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIR 735
S ++ + G+G LV +Q F+ +A G+ I +IR
Sbjct: 89 MSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIR 148
Query: 736 SLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDA 795
F I+ QEI WFD + +V G + RL+ D
Sbjct: 149 KQFFHAIMRQEIGWFD--------VHDV---------------------GELNTRLTDDV 179
Query: 796 STVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGF 855
S + +GD + + Q+++T G ++ FT W L ++L ++P++ + V K L F
Sbjct: 180 SKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSF 239
Query: 856 SADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGF 915
+ + Y +A VA + +++IRTV +F + K ++ Y+K + G++ + + I
Sbjct: 240 TDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISI 299
Query: 916 GCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAK 975
G +FL++Y + A F+ G+ LV G+ + +V VFF++ + A +V Q + A+
Sbjct: 300 GAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANAR 359
Query: 976 DSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPS 1035
+A IF+IID+KP IDS S +G + + G++E ++V+F+YP+R +++I K L+L + S
Sbjct: 360 GAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQS 419
Query: 1036 AKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPIL 1095
+T+ALVG SG GKST + L++R YDP G + +DG D++T + +LR+ +G+V QEP+L
Sbjct: 420 GQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVL 479
Query: 1096 FNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQR 1155
F +I NI YG+E T DEI A ANA+ FI LP +DT VGERG QLSGGQKQR
Sbjct: 480 FATTIAENIRYGRE-NVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQR 538
Query: 1156 IAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTI 1215
IAIAR +++NPKILLLDEATSALD ESE +VQ ALD+ RTT+V+AHRL+T+R AD I
Sbjct: 539 IAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVI 598
Query: 1216 AVIKNGAVAEKGRHDELMRITDGVYASLVALHSS 1249
A +G + EKG HDELM+ G+Y LV + ++
Sbjct: 599 AGFDDGVIVEKGNHDELMK-EKGIYFKLVTMQTA 631
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 927 bits (2397), Expect = 0.0
Identities = 521/1290 (40%), Positives = 758/1290 (58%), Gaps = 111/1290 (8%)
Query: 27 KQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSN--PADAI 84
K V + +F +A LD M++GT++A+ +G+A PLM L G++ ++F S P +A
Sbjct: 30 KPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNAT 89
Query: 85 KQVSKVSL--------------LFVYLAIGSG--IASFLQVTCWMVTGERQAARIRSLYL 128
++V+ + Y IG+G I +++QV+ W + RQ +IR +
Sbjct: 90 NNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFF 149
Query: 129 KTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKG 188
I+ Q+I +FD + GE+ R++ D I E +G+K+G FFQ + F GGF++ F +G
Sbjct: 150 HAIMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRG 208
Query: 189 WRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEK 248
W+L +V+LA P + ++ + +++ + + AYA+AG V ++ + AIRTV +F G+K
Sbjct: 209 WKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQK 268
Query: 249 KAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTV 308
K +E+YN+ ++ A +K+ I + +G + + +Y LA WYG+ LVI K Y+ G V
Sbjct: 269 KELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQV 328
Query: 309 MTVIIALMTGGI--------------------------------------------IKGD 324
+TV A++ G IKG+
Sbjct: 329 LTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGN 388
Query: 325 IELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEV 384
+E +++ F YP+R DVQI G +L V SG T ALVG SG GKST + LL+R YDP G V
Sbjct: 389 LEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVV 448
Query: 385 LIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKK 444
IDG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +EI A+ ANA
Sbjct: 449 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 508
Query: 445 FIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQE 504
FI KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ
Sbjct: 509 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 568
Query: 505 ALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQE 564
AL+K RTT+V+AHRL+T+RNADIIA G IVE+G H L M G Y +L+ Q
Sbjct: 569 ALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEEL-MREKGIYFKLVMTQT 627
Query: 565 GDNEAE-GSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSG 623
NE E G+ E+ DNL++ S + S S +R S S+ H Q + +
Sbjct: 628 AGNEIELGNEVGESKNEIDNLDMSSKDSAS-----SLIRRRSTRRSIRGPHDQDRKLSTK 682
Query: 624 EIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAV 683
E ++ D+ P +S WR+ KLN E P ++G AIVNG + P F +FS V
Sbjct: 683 EALDEDV----------PPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKV 732
Query: 684 ISMFYK--PPEQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEK 741
+ +F + E +R +S +SLLF+ LG+++ + LQ F FG AG L +R+R + F+
Sbjct: 733 VGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKS 792
Query: 742 IVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSL 801
++ Q++SWFD+P ++ +GA+ RL+ DA VK
Sbjct: 793 MLRQDVSWFDNPKNT---------------------------TGALTTRLANDAGQVKGA 825
Query: 802 VGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKV 861
G +A+I QNI+ + G++I+ W L ++L + P+I + G+V+MK L G + K
Sbjct: 826 TGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 885
Query: 862 MYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLV 921
E + ++A +A+ + RTV S E K +MY++ P + ++ V GI F + +
Sbjct: 886 ELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAM 945
Query: 922 LYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASI 981
+Y + A F G+ LV TF V VF A+ A+AV Q ++ APD KAK SA+ I
Sbjct: 946 MYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHI 1005
Query: 982 FEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIAL 1041
II+ P IDS S G+ T+ G+++ V FNYPTRPDI + + L+L + +T+AL
Sbjct: 1006 IMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLAL 1065
Query: 1042 VGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIR 1101
VG SG GKSTV+ LLERFYDP +G + LDG ++ + WLR +G+V QEPILF+ SI
Sbjct: 1066 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIA 1125
Query: 1102 ANIGYGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIAR 1160
NI YG ++DEI AA AN H FI +LPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1126 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1185
Query: 1161 TMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKN 1220
+++ P ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I VI+N
Sbjct: 1186 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1245
Query: 1221 GAVAEKGRHDELMRITDGVYASLVALHSSA 1250
G V E G H +L+ G+Y S+V++ + A
Sbjct: 1246 GKVKEHGTHQQLL-AQKGIYFSMVSVQAGA 1274
Score = 412 bits (1059), Expect = e-114
Identities = 230/627 (36%), Positives = 355/627 (55%), Gaps = 51/627 (8%)
Query: 638 KKKPKVSIWRLAKL-NKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPE---- 692
+KKP VS++ + + + +L+G +AAI++GV P+ +F + F
Sbjct: 28 EKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTN 87
Query: 693 ---------------QQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSL 737
+ +E ++ + G+G L++ +Q F+ +A G+ I +IR
Sbjct: 88 ATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK 147
Query: 738 TFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDAST 797
F I++QEI WFD + +V G + RL+ D S
Sbjct: 148 FFHAIMNQEIGWFD--------VHDV---------------------GELNTRLTDDVSK 178
Query: 798 VKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSA 857
+ +GD + + Q ++T G +I FT W L ++L ++P++ + + K L F+
Sbjct: 179 INEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTD 238
Query: 858 DAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGC 917
Y +A VA + +++IRTV +F + K ++ Y+ + G++ + + I G
Sbjct: 239 KELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGA 298
Query: 918 SFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDS 977
+FL++Y + A F+ G+ LV + + +V VFFA+ + A ++ Q + A+ +
Sbjct: 299 AFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGA 358
Query: 978 AASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAK 1037
A IF IID+KP IDS S G + + G++E ++++F+YP+R D+QI K L+L + S +
Sbjct: 359 AYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQ 418
Query: 1038 TIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFN 1097
T+ALVG SG GKST + LL+R YDP G + +DG D++T + +LR+ +G+V QEP+LF
Sbjct: 419 TVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 478
Query: 1098 ESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIA 1157
+I NI YG+E T DEI A ANA+ FI LP +DT VGERG QLSGGQKQRIA
Sbjct: 479 TTIAENIRYGRE-NVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 537
Query: 1158 IARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAV 1217
IAR +++NPKILLLDEATSALD ESE +VQ ALD+ RTT+V+AHRL+T+R AD IA
Sbjct: 538 IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAG 597
Query: 1218 IKNGAVAEKGRHDELMRITDGVYASLV 1244
G + E+G H+ELMR G+Y LV
Sbjct: 598 FDGGVIVEQGNHEELMR-EKGIYFKLV 623
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein 3)
(MDR1A)
Length = 1276
Score = 923 bits (2385), Expect = 0.0
Identities = 518/1289 (40%), Positives = 757/1289 (58%), Gaps = 110/1289 (8%)
Query: 27 KQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGS--------S 78
K V +F +A LD M++GT++A+ +G+A PLM L G++ ++F S +
Sbjct: 30 KPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNST 89
Query: 79 NPADAIKQVSKVSL-------LFVYLAIGSG--IASFLQVTCWMVTGERQAARIRSLYLK 129
N ++A K+ L + Y IG+G I +++QV+ W + RQ +IR +
Sbjct: 90 NMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFH 149
Query: 130 TILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGW 189
I+ Q+I +FD + GE+ R++ D I E +G+K+G FFQ + F GGF++ F +GW
Sbjct: 150 AIMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGW 208
Query: 190 RLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKK 249
+L +V+LA P + ++ + +++ + + AYA+AG V ++ + AIRTV +F G+KK
Sbjct: 209 KLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKK 268
Query: 250 AIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVM 309
+E+YN+ ++ A +K+ I + +G + + +Y LA WYG+ LVI K Y+ G V+
Sbjct: 269 ELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVL 328
Query: 310 TVIIALMTGGI--------------------------------------------IKGDI 325
TV +++ G I+G++
Sbjct: 329 TVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL 388
Query: 326 ELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVL 385
E +++ F YP+R +VQI G +L V SG T ALVG SG GKST + L++R YDP G V
Sbjct: 389 EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVS 448
Query: 386 IDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKF 445
IDG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +EI A+ ANA F
Sbjct: 449 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF 508
Query: 446 IDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEA 505
I KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ A
Sbjct: 509 IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 568
Query: 506 LEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEG 565
L+K RTT+V+AHRL+T+RNAD+IA G IVE+G H L M G Y +L+ Q
Sbjct: 569 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMTQTA 627
Query: 566 DNEAE-GSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGE 624
NE E G+ ++ DNL++ S +GS S +R S S+ H Q + + E
Sbjct: 628 GNEIELGNEACKSKDEIDNLDMSSKDSGS-----SLIRRRSTRKSICGPHDQDRKLSTKE 682
Query: 625 IVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVI 684
++ D+ P S WR+ KLN E P ++G AI+NG + P F +FS V+
Sbjct: 683 ALDEDV----------PPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVV 732
Query: 685 SMFYK--PPEQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKI 742
+F PPE QR+ S +SLLF+ LG+++ + LQ F FG AG L +R+R + F+ +
Sbjct: 733 GVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSM 792
Query: 743 VHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLV 802
+ Q++SWFDDP ++ +GA+ RL+ DA+ VK
Sbjct: 793 LRQDVSWFDDPKNT---------------------------TGALTTRLANDAAQVKGAT 825
Query: 803 GDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVM 862
G +A+I QNI+ + G++I+ W L ++L + P+I + G+V+MK L G + K
Sbjct: 826 GSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 885
Query: 863 YEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVL 922
E + ++A +A+ + RTV S E K MY++ P + ++ V GI F + ++
Sbjct: 886 LEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMM 945
Query: 923 YCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIF 982
Y + A F G+ LV TF V VF A+ A+AV Q ++ APD KA SA+ I
Sbjct: 946 YFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHII 1005
Query: 983 EIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALV 1042
II+ P+IDS S G+ + G+++ FNYPTRP I + + LSL + +T+ALV
Sbjct: 1006 RIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALV 1065
Query: 1043 GESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRA 1102
G SG GKSTV+ LLERFYDP +G + LDG ++K + WLR Q+G+V QEPILF+ SI
Sbjct: 1066 GSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAE 1125
Query: 1103 NIGYGKEGGATE-DEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIART 1161
NI YG +EI+ AA AN H FI +LPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1126 NIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARA 1185
Query: 1162 MLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNG 1221
+++ P ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I VI+NG
Sbjct: 1186 LVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNG 1245
Query: 1222 AVAEKGRHDELMRITDGVYASLVALHSSA 1250
V E G H +L+ G+Y S+V++ + A
Sbjct: 1246 KVKEHGTHQQLL-AQKGIYFSMVSVQAGA 1273
Score = 410 bits (1055), Expect = e-114
Identities = 228/626 (36%), Positives = 356/626 (56%), Gaps = 50/626 (7%)
Query: 638 KKKPKVSIWRLAKL-NKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQQR- 695
+KKP VS+ + + + +L+G +AAI++GV P+ +F + F +
Sbjct: 28 EKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKN 87
Query: 696 -----------------KESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLT 738
+E ++ + G+G L++ +Q F+ +A G+ I +IR
Sbjct: 88 STNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKF 147
Query: 739 FEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTV 798
F I++QEI WFD + +V G + RL+ D S +
Sbjct: 148 FHAIMNQEIGWFD--------VHDV---------------------GELNTRLTDDVSKI 178
Query: 799 KSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSAD 858
+GD + + Q ++T G +I FT W L ++L ++P++ + + K L F+
Sbjct: 179 NEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDK 238
Query: 859 AKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCS 918
Y +A VA + +++IRTV +F + K ++ Y+ + G++ + + I G +
Sbjct: 239 ELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAA 298
Query: 919 FLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSA 978
FL++Y + A F+ G+ LV + + +V VFF++ + A +V Q + A+ +A
Sbjct: 299 FLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAA 358
Query: 979 ASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKT 1038
+F+IID+KP IDS S +G + + G++E ++++F+YP+R ++QI K L+L + S +T
Sbjct: 359 YEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQT 418
Query: 1039 IALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNE 1098
+ALVG SG GKST + L++R YDP G + +DG D++T + +LR+ +G+V QEP+LF
Sbjct: 419 VALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFAT 478
Query: 1099 SIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAI 1158
+I NI YG+E T DEI A ANA+ FI LP +DT VGERG QLSGGQKQRIAI
Sbjct: 479 TIAENIRYGRE-DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAI 537
Query: 1159 ARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVI 1218
AR +++NPKILLLDEATSALD ESE +VQ ALD+ RTT+V+AHRL+T+R AD IA
Sbjct: 538 ARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGF 597
Query: 1219 KNGAVAEKGRHDELMRITDGVYASLV 1244
G + E+G HDELMR G+Y LV
Sbjct: 598 DGGVIVEQGNHDELMR-EKGIYFKLV 622
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1279
Score = 904 bits (2335), Expect = 0.0
Identities = 514/1290 (39%), Positives = 753/1290 (57%), Gaps = 110/1290 (8%)
Query: 22 RDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSS--- 78
+ KT + + LF ++D D M +GTI A+A+G PLM + G + + F +
Sbjct: 32 KKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGN 91
Query: 79 ------------NPADAIKQVSKVSLLFVYLAIGSGI--ASFLQVTCWMVTGERQAARIR 124
NP +++ + Y +G+G+ A+++QV+ W + RQ +IR
Sbjct: 92 FSFPVNFSLSLLNPGKILEE-EMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIR 150
Query: 125 SLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMA 184
+ IL+Q+I +FD T E+ R++ D I E +G+KVG FFQ + F GF++
Sbjct: 151 QKFFHAILRQEIGWFDINDTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVG 209
Query: 185 FIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASF 244
FI+GW+L +V++A P + ++ A + +++ S + AYA+AG V ++ +GAIRTV +F
Sbjct: 210 FIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAF 269
Query: 245 TGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYN 304
G+ K +E+Y ++ A +K+ I + +G+ + + +Y LA WYGS LVI K Y
Sbjct: 270 GGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYT 329
Query: 305 GGTVMTVIIALMTGGI-------------------------------------------- 320
G MTV +++ G
Sbjct: 330 IGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS 389
Query: 321 IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPD 380
IKG++E DV F YP+R +V+I G +L V SG T ALVG SG GKST + L++R YDPD
Sbjct: 390 IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
Query: 381 AGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLA 440
G + IDG +++N + ++RE IG+VSQEP+LF+T+I ENI YG+ T +EI A+ A
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 441 NAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESER 500
NA +FI KLPQ DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 501 IVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLI 560
VQ AL+K RTT+V+AHRL+T+RNAD+IA + G IVE+G+HS L M +G Y +L+
Sbjct: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MKKEGVYFKLV 628
Query: 561 RLQEGDNEAEGSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRG 620
+Q ++ + SE +L D + MA + + F S + S +SL
Sbjct: 629 NMQTSGSQIQ----SEEFELNDE-KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSL-- 681
Query: 621 LSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLF 680
D+E L+ P VS ++ KLNK E P ++G + AI NG + P F +F
Sbjct: 682 --------DVETDGLE-ANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIF 732
Query: 681 SAVISMFYKPPEQ-QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTF 739
S +I++F + ++++ +SL+F+ LG+++ LQ F FG AG L R+RS+ F
Sbjct: 733 SEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAF 792
Query: 740 EKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVK 799
+ ++ Q++SWFDD +S +GA+ RL+ DA+ V+
Sbjct: 793 KAMLRQDMSWFDDHKNS---------------------------TGALSTRLATDAAQVQ 825
Query: 800 SLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADA 859
G +ALI QNI+ + G++I+F W L ++L + P+I + GIV+MK L G +
Sbjct: 826 GATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 885
Query: 860 KVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSF 919
K E A ++A +A+ +IRTV S E K MY +K GP + V+ + GI F S
Sbjct: 886 KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQ 945
Query: 920 LVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAA 979
+Y + A F G+ L+ +G F +V VF A+ A+A+ ++ APD KAK SAA
Sbjct: 946 AFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAA 1005
Query: 980 SIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTI 1039
+F + + +P IDS S G+ + G+I V FNYPTR ++ + + LSL + +T+
Sbjct: 1006 HLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTL 1065
Query: 1040 ALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNES 1099
ALVG SG GKSTV+ LLERFYDP +G +LLDG + K + WLR Q+G+V QEPILF+ S
Sbjct: 1066 ALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCS 1125
Query: 1100 IRANIGYGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAI 1158
I NI YG ++DEI++AA AAN H FI LP Y+T VG++GTQLSGGQKQRIAI
Sbjct: 1126 IAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAI 1185
Query: 1159 ARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVI 1218
AR +++ P+ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I V
Sbjct: 1186 ARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVF 1245
Query: 1219 KNGAVAEKGRHDELMRITDGVYASLVALHS 1248
+NG V E G H +L+ G+Y S+V++ +
Sbjct: 1246 QNGRVKEHGTHQQLL-AQKGIYFSMVSVQA 1274
Score = 407 bits (1047), Expect = e-113
Identities = 238/647 (36%), Positives = 357/647 (54%), Gaps = 55/647 (8%)
Query: 627 ESDIEQGQLDNKKKPK------VSIWRLAKLNKPEIPVIL-LGAIAAIVNGVVFPIFGFL 679
E D E G +K+ K + + L + + + + + LG I AI +G P+ +
Sbjct: 18 EGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIV 77
Query: 680 FSAVISMFY-----------------KPPEQQRKESRFWSLLFVGLGLVTLVILPLQNFF 722
F + F P + +E ++ + GLG LV +Q F
Sbjct: 78 FGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSF 137
Query: 723 FGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESS 782
+ +A G+ I +IR F I+ QEI WFD N TE N
Sbjct: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDI--------------------NDTTELN--- 174
Query: 783 CSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMIL 842
RL+ D S + +GD + + Q ++T AG ++ F W L +++ ++P++
Sbjct: 175 ------TRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILG 228
Query: 843 MQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAK 902
+ V K L FS Y +A VA +A+ +IRTV +F ++K ++ Y K +
Sbjct: 229 LSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKE 288
Query: 903 QGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVS 962
G++ + + I G +FL++Y + A F+ GS LV + T VFF++ + A +V
Sbjct: 289 IGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVG 348
Query: 963 QTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPD 1022
Q A+ +A IF+IID+ P IDS S G +++ G++E V+F+YP+R +
Sbjct: 349 QAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRAN 408
Query: 1023 IQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWL 1082
++I K L+L + S +T+ALVG SG GKST + L++R YDP+ G I +DG D++ F +++L
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 1083 RQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVG 1142
R+ +G+V QEP+LF+ +I NI YG+ G T DEI A ANA+ FI LP +DT VG
Sbjct: 469 REIIGVVSQEPVLFSTTIAENICYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVG 527
Query: 1143 ERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVV 1202
ERG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE VQ ALD+ RTT+V+
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
Query: 1203 AHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLVALHSS 1249
AHRL+T+R AD IA ++G + E+G H ELM+ +GVY LV + +S
Sbjct: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMK-KEGVYFKLVNMQTS 633
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 904 bits (2335), Expect = 0.0
Identities = 509/1287 (39%), Positives = 750/1287 (57%), Gaps = 116/1287 (9%)
Query: 27 KQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNPA----- 81
K V + +F +AD LD MI+GT++A+ +G PL+ L GN+ ++F + +
Sbjct: 30 KPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSI 89
Query: 82 ------DAIKQVSKVSL-------LFVYLAIGSG--IASFLQVTCWMVTGERQAARIRSL 126
++ +S SL + Y IG+G I +++QV+ W + RQ +IR
Sbjct: 90 TNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK 149
Query: 127 YLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFI 186
+ I+ Q+I +FD + GE+ R++ D I + +G+K+G FFQ + F GF++ FI
Sbjct: 150 FFHAIMNQEIGWFDVH-DVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFI 208
Query: 187 KGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTG 246
GW+L +V+LA P + ++ A + V+ +++ AYA+AG V ++ + AIRTV +F G
Sbjct: 209 SGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGG 268
Query: 247 EKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGG 306
++K +E+YN ++ A +K+ I + IG+ + + +Y LA WYG+ LV+ Y+ G
Sbjct: 269 QQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIG 328
Query: 307 TVMTVIIALMTGGI--------------------------------------------IK 322
V+TV +++ G I
Sbjct: 329 EVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIM 388
Query: 323 GDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAG 382
G++E ++V F YP+R +VQI G +L V SG T ALVG SG GKST + L++R YDP G
Sbjct: 389 GNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEG 448
Query: 383 EVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANA 442
V IDG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +EI A+ ANA
Sbjct: 449 VVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 508
Query: 443 KKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIV 502
FI KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +V
Sbjct: 509 YDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 568
Query: 503 QEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRL 562
Q AL+K RTT+V+AHRL+T+RNAD+IA G IVE+G H L M G Y +L+
Sbjct: 569 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMT 627
Query: 563 QEGDNEAE-GSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGL 621
Q NE E G+ + D + S + S R S RS+ HR R L
Sbjct: 628 QTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSV-------HRKQDQERRL 680
Query: 622 S-GEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLF 680
S E V+ D+ P VS WR+ LN E P +L+G + A++NG + P+F +F
Sbjct: 681 SMKEAVDEDV----------PLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVF 730
Query: 681 SAVISMFYKPP--EQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLT 738
S ++ +F + E +R+ +SL F+ +GL++ V Q F FG AG L +R+R +
Sbjct: 731 SRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMV 790
Query: 739 FEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTV 798
F+ ++ Q+ISWFDD +S +G++ RL+ DAS+V
Sbjct: 791 FKSMLRQDISWFDDHKNS---------------------------TGSLTTRLASDASSV 823
Query: 799 KSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSAD 858
K +G +A++ QN++ + G++++ W L +++V+ P+I++ GI++MK L G +
Sbjct: 824 KGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALK 883
Query: 859 AKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCS 918
K E + ++A +A+ + RT+ S E K MY++ P + ++ V GI F +
Sbjct: 884 DKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFT 943
Query: 919 FLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSA 978
++Y + A F G+ LV TF V VF A+ A+A T++ APD KAK SA
Sbjct: 944 QAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSA 1003
Query: 979 ASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKT 1038
+ I II+ P+IDS S G+ + G+++ V FNYPTRP+I + + LSL + +T
Sbjct: 1004 SHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQT 1063
Query: 1039 IALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNE 1098
+ALVG SG GKSTV+ LLERFYDP +G + LDG ++K + WLR +G+V QEPILF+
Sbjct: 1064 LALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDC 1123
Query: 1099 SIRANIGYGKEGGA-TEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIA 1157
SI NI YG A + +EI+ AA AN H FI +LPD Y+T VG++GTQLSGGQKQRIA
Sbjct: 1124 SIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIA 1183
Query: 1158 IARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAV 1217
IAR +++ P ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I V
Sbjct: 1184 IARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVV 1243
Query: 1218 IKNGAVAEKGRHDELMRITDGVYASLV 1244
I+NG V E G H +L+ G+Y S+V
Sbjct: 1244 IENGKVKEHGTHQQLL-AQKGIYFSMV 1269
Score = 412 bits (1058), Expect = e-114
Identities = 228/629 (36%), Positives = 357/629 (56%), Gaps = 53/629 (8%)
Query: 638 KKKPKVSIWRLAKL-NKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPP----- 691
+KKP V ++ + + + + ++LG +AAI++G + P+ +F + F K
Sbjct: 28 EKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILP 87
Query: 692 ----------------EQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIR 735
+E ++ + G+G L++ +Q + +A G+ I +IR
Sbjct: 88 SITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIR 147
Query: 736 SLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDA 795
F I++QEI WFD + +V G + RL+ D
Sbjct: 148 QKFFHAIMNQEIGWFD--------VHDV---------------------GELNTRLTDDV 178
Query: 796 STVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGF 855
S + +GD + + Q+I+T +AG +I F + W L ++L ++P+I + + K L F
Sbjct: 179 SKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSF 238
Query: 856 SADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGF 915
+ Y +A VA + +++IRTV +F + K ++ Y+K G++ + + I
Sbjct: 239 TNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISI 298
Query: 916 GCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAK 975
G ++L++Y + A F+ G+ LV + + EV VFF++ + ++ A+
Sbjct: 299 GIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANAR 358
Query: 976 DSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPS 1035
+A IF+IID++P IDS S G ++++G++E ++V+FNYP+R ++QI K L+L + S
Sbjct: 359 GAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKS 418
Query: 1036 AKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPIL 1095
+T+ALVG SG GKST + L++R YDP G + +DG D++T + +LR+ +G+V QEP+L
Sbjct: 419 GQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVL 478
Query: 1096 FNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQR 1155
F +I NI YG+E T DEI A ANA+ FI LP +DT VGERG QLSGGQKQR
Sbjct: 479 FATTIAENIRYGRE-DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQR 537
Query: 1156 IAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTI 1215
IAIAR +++NPKILLLDEATSALD ESE +VQ ALD+ RTT+V+AHRL+T+R AD I
Sbjct: 538 IAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVI 597
Query: 1216 AVIKNGAVAEKGRHDELMRITDGVYASLV 1244
A G + E+G HDELMR G+Y LV
Sbjct: 598 AGFDGGVIVEQGNHDELMR-EKGIYFKLV 625
Score = 347 bits (891), Expect = 9e-95
Identities = 196/563 (34%), Positives = 303/563 (53%), Gaps = 49/563 (8%)
Query: 47 MIIGTISAVANGLASPLMTLFLGNVINAFGSSNPADAIKQVSKV-SLLFVYLAIGSGIAS 105
+++G + AV NG P+ + ++ F + + +Q + SL F+ + + S +
Sbjct: 709 LLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTY 768
Query: 106 FLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETN-TGEVIGRMSGDTILIQEAMG 164
F Q + GE R+R + K++L+QDI++FD N TG + R++ D ++ AMG
Sbjct: 769 FFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMG 828
Query: 165 EKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAY 224
++ Q +N G +++ + GW+L ++L+ +P + + G +++ + + +
Sbjct: 829 ARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQL 888
Query: 225 AEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAF 284
+G + + + RT+ S T E+K Y +++ Y +K+ V G + +
Sbjct: 889 EISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMY 948
Query: 285 CTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTGG------------------------- 319
+Y +G+ LV ++ VM V A++ G
Sbjct: 949 FSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIR 1008
Query: 320 -------------------IIKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVG 360
+++G+++ V F YP RP++ + G SL V G T ALVG
Sbjct: 1009 IIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVG 1068
Query: 361 QSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIREN 420
SG GKSTV+ LLERFYDP AG V +DG +K L ++W+R +G+VSQEPILF SI EN
Sbjct: 1069 SSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAEN 1128
Query: 421 IAYG--KEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAI 478
IAYG + EEI A AN +FID LP +T G GTQLSGGQKQRIAIARA+
Sbjct: 1129 IAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARAL 1188
Query: 479 LKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGK 538
++ P ILLLDEATSALD ESE++VQEAL+K RT +V+AHRL+TI+NAD+I V++ GK
Sbjct: 1189 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGK 1248
Query: 539 IVERGTHSGLTMDPDGAYSQLIR 561
+ E GTH L + G Y +++
Sbjct: 1249 VKEHGTHQQL-LAQKGIYFSMVQ 1270
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1281
Score = 893 bits (2307), Expect = 0.0
Identities = 508/1286 (39%), Positives = 748/1286 (57%), Gaps = 122/1286 (9%)
Query: 35 LFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSS---------------N 79
LF ++D D M++GTI A+A+G PLM + G + + F ++ N
Sbjct: 45 LFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFSLPVNFSLSMIN 104
Query: 80 PADAIKQVSKVSLLFVYLAIGSGI--ASFLQVTCWMVTGERQAARIRSLYLKTILQQDIA 137
P +++ + Y +G G+ A+++QV+ W + RQ +IR + IL+Q++
Sbjct: 105 PGRILEE-EMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMG 163
Query: 138 FFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLA 197
+FD + T E+ R++ D I E +G+KVG FFQ + F GF++ FI+GW+L +V++A
Sbjct: 164 WFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMA 222
Query: 198 CVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSK 257
P + ++ A + +++ S + AYA+AG V ++ +GAIRTV +F G+ K +E+Y
Sbjct: 223 ISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKH 282
Query: 258 IKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMT 317
++ A +K+ I + +G+ + + +Y LA WYGS LVI K Y G MTV +++
Sbjct: 283 LENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILI 342
Query: 318 GGI--------------------------------------------IKGDIELRDVSFR 333
G IKG+++ DV F
Sbjct: 343 GAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFS 402
Query: 334 YPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKN 393
YP+R +++I G +L V SG T ALVG SG GK+T + LL+R YDP G + IDG +++N
Sbjct: 403 YPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRN 462
Query: 394 LQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGL 453
+R++RE IG+VSQEP+LF+T+I ENI YG+ T EEI A+ ANA +FI KLPQ
Sbjct: 463 FNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKF 522
Query: 454 DTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKR 513
DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE VQ AL+K R
Sbjct: 523 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGR 582
Query: 514 TTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDN------ 567
TT+V+AHRL+T+RNAD+IA + G IVE+G+HS L M +G Y +L+ +Q +
Sbjct: 583 TTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MQKEGVYFKLVNMQTSGSQILSQE 641
Query: 568 -EAEGSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIV 626
E E S + AD + N SH+ +ST++ S SS +H H
Sbjct: 642 FEVELSEEKAADGMTPN-GWKSHIFRNSTKK-------SLKSSRAHHH------------ 681
Query: 627 ESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISM 686
D++ +LD P VS ++ KLNK E P ++G + AIVNG + P + S +I++
Sbjct: 682 RLDVDADELD-ANVPPVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAI 740
Query: 687 FYKPPEQ-QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQ 745
F + ++++ +SL+F+GLG+++ LQ F FG AG L R+RS+ F+ ++ Q
Sbjct: 741 FGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQ 800
Query: 746 EISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDT 805
++SWFDD +S +GA+ RL+ D + V+ G
Sbjct: 801 DMSWFDDYKNS---------------------------TGALSTRLATDRAQVQGATGTR 833
Query: 806 MALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEE 865
+ALI QN + + G++I+F W L ++L + P I + GIV+MK L G + K E
Sbjct: 834 LALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEA 893
Query: 866 ASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCT 925
A ++A +A+ +IRTV S E K MY +K P + V++ + GI F S +Y +
Sbjct: 894 AGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFS 953
Query: 926 NAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEII 985
A F G+ L+ +G F +V VF A+ A+A+ ++ APD KAK SAA +F +
Sbjct: 954 YAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLF 1013
Query: 986 DSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGES 1045
+ +P IDS S G+ + G + V FNYPTR ++ + + LSL + +T+ALVG S
Sbjct: 1014 ERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSS 1073
Query: 1046 GSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIG 1105
G GKSTV+ LLERFYDP +G +LLDG + K + WLR Q+G+V QEP+LF+ SI NI
Sbjct: 1074 GCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIA 1133
Query: 1106 YGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLK 1164
YG ++DEI+ AA AAN H FI LP Y T VG++GTQLSGGQKQR+AI R +++
Sbjct: 1134 YGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIR 1193
Query: 1165 NPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVA 1224
P++LLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I VI+NG V
Sbjct: 1194 QPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVK 1253
Query: 1225 EKGRHDELMRITDGVYASLVALHSSA 1250
E G H +L+ G+Y S+V + + A
Sbjct: 1254 EHGTHQQLL-AQKGIYFSMVNIQAGA 1278
Score = 406 bits (1044), Expect = e-112
Identities = 241/648 (37%), Positives = 357/648 (54%), Gaps = 55/648 (8%)
Query: 626 VESDIEQGQLDNK---KKPKVSIWRLAKLNK----PEIPVILLGAIAAIVNGVVFPIFGF 678
VE D E G + N+ KK KV++ L + + +LLG I AI +G P+
Sbjct: 17 VEGDFELGSISNQGRNKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMI 76
Query: 679 LFSAVISMFYK-----------------PPEQQRKESRFWSLLFVGLGLVTLVILPLQNF 721
+F + F P +E ++ + GLG LV +Q
Sbjct: 77 VFGEMTDKFVNNAGNFSLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVS 136
Query: 722 FFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNES 781
F+ +A G+ I++IR F I+ QE+ WFD TE N
Sbjct: 137 FWTLAAGRQIKKIRQNFFHAILRQEMGWFDIKG--------------------TTELN-- 174
Query: 782 SCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMI 841
RL+ D S + +GD + + Q ++T AG ++ F W L +++ ++P++
Sbjct: 175 -------TRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPIL 227
Query: 842 LMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPA 901
+ V K L FS Y +A VA +A+ +IRTV +F ++K ++ Y K
Sbjct: 228 GLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK 287
Query: 902 KQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAV 961
K G++ + + I G +FL++Y + A F+ GS LV + T VFF++ + A +V
Sbjct: 288 KIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSV 347
Query: 962 SQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRP 1021
Q A+ +A IF+IID+ P IDS S G +++ G+++ V+F+YP+R
Sbjct: 348 GQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRA 407
Query: 1022 DIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSW 1081
+I+I K L+L + S +T+ALVG SG GK+T + LL+R YDP G I +DG D++ F + +
Sbjct: 408 NIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRY 467
Query: 1082 LRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSV 1141
LR+ +G+V QEP+LF+ +I NI YG+ G T +EI A ANA+ FI LP +DT V
Sbjct: 468 LREIIGVVSQEPVLFSTTIAENIRYGR-GNVTMEEIKKAVKEANAYEFIMKLPQKFDTLV 526
Query: 1142 GERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVV 1201
GERG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE VQ ALD+ RTT+V
Sbjct: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 1202 VAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLVALHSS 1249
+AHRL+T+R AD IA ++G + E+G H ELM+ +GVY LV + +S
Sbjct: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQ-KEGVYFKLVNMQTS 633
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 890 bits (2301), Expect = 0.0
Identities = 504/1292 (39%), Positives = 745/1292 (57%), Gaps = 117/1292 (9%)
Query: 22 RDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSS--- 78
+ K V + +F +AD LD M++GT++AV +G + PL+ L GN+ ++F +
Sbjct: 26 KKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETS 85
Query: 79 -----------NPADAIK---QVSKVSLLFVYLAIGSG--IASFLQVTCWMVTGERQAAR 122
N + I + + + Y IG+G I +++QV+ W + RQ +
Sbjct: 86 IWPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINK 145
Query: 123 IRSLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFV 182
IR + I+ Q+I +FD + GE+ R++ D I + +G+K+G FFQ + F F+
Sbjct: 146 IRQKFFHAIMNQEIGWFDVH-DIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFI 204
Query: 183 MAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVA 242
+ FI GW+L +V+LA P + ++ A + V+ +++ AYA+AG V ++ + AIRTV
Sbjct: 205 VGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVI 264
Query: 243 SFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKG 302
+F G+ K +E+YN ++ A +K+ + + IG+ + + +Y LA WYG+ LV+
Sbjct: 265 AFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNE 324
Query: 303 YNGGTVMTVIIALMTGGI------------------------------------------ 320
Y+ G V+TV +++ G
Sbjct: 325 YSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKP 384
Query: 321 --IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYD 378
+ G++E ++V F YP+R ++I G +L V SG T ALVG+SG GKST + LL+R YD
Sbjct: 385 DSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYD 444
Query: 379 PDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAIT 438
P G V IDG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +EI A+
Sbjct: 445 PTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK 504
Query: 439 LANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAES 498
ANA FI KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ES
Sbjct: 505 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 564
Query: 499 ERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQ 558
E +VQ AL+K RTT+V+AHRL+T+RNAD+IA G IVE+G H L M G Y +
Sbjct: 565 EAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MKEKGIYCR 623
Query: 559 LIRLQEGDNEAE-GSRK--SEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHS 615
L+ +Q NE E GS S++D + L S S + R S RSI + R S
Sbjct: 624 LVMMQTRGNEVELGSEADGSQSDTIASELT--SEEFKSPSVRKSTCRSICGSQDQERRVS 681
Query: 616 QSLRGLSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPI 675
E + D+ P VS W + KLN E P +++G + A++NG + P+
Sbjct: 682 VK------EAQDEDV----------PLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPV 725
Query: 676 FGFLFSAVISMFYK--PPEQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIER 733
F +FS +I +F + P+ +++ +SL F+ +G++ V Q F FG AG L +R
Sbjct: 726 FSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKR 785
Query: 734 IRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSI 793
+R + F+ ++ Q+ISWFDD +S +GA+ RL+
Sbjct: 786 LRYMVFKSMLRQDISWFDDHRNS---------------------------TGALTTRLAS 818
Query: 794 DASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLK 853
DA+ VK + +A I QN++ + G++I+ W L +++V+ P+I++ G+++MK L
Sbjct: 819 DAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLS 878
Query: 854 GFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGI 913
G + K E + ++A +A+ + RTV S E K +MY++ P + ++ V GI
Sbjct: 879 GQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGI 938
Query: 914 GFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNK 973
F + ++Y + A F G+ LV H TF V VF A+ AIA ++ APD K
Sbjct: 939 TFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAK 998
Query: 974 AKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSI 1033
AK SA+ I I++ P IDS S G+ + G+++ V FNYPTRPDI + + LSL +
Sbjct: 999 AKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEV 1058
Query: 1034 PSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEP 1093
+T+ALVG SG GKSTV+ LLERFYDP +G + LDG ++K + WLR +G+V QEP
Sbjct: 1059 KKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEP 1118
Query: 1094 ILFNESIRANIGYGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQ 1152
ILF+ SI NI YG ++DEI AA AN H FI +LPD Y+T VG++GTQLSGGQ
Sbjct: 1119 ILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQ 1178
Query: 1153 KQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGA 1212
KQRIAIAR +++ P ILLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ A
Sbjct: 1179 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1238
Query: 1213 DTIAVIKNGAVAEKGRHDELMRITDGVYASLV 1244
D I VI+NG V E G H +L+ G+Y S+V
Sbjct: 1239 DLIVVIQNGKVKEHGTHQQLL-AQKGIYFSMV 1269
Score = 399 bits (1026), Expect = e-110
Identities = 218/610 (35%), Positives = 347/610 (56%), Gaps = 51/610 (8%)
Query: 659 ILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQ--------------------QRKES 698
++LG +AA+++G P+ +F + F K ++
Sbjct: 51 MVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQSEINNTEVISGSLEEDM 110
Query: 699 RFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRY 758
++ + G+G L++ +Q F+ +A G+ I +IR F I++QEI WFD
Sbjct: 111 ATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFD------- 163
Query: 759 VIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIA 818
+ ++ G + RL+ D S + +GD + + Q+I+T +A
Sbjct: 164 -VHDI---------------------GELNTRLTDDVSKINDGIGDKIGMFFQSIATFLA 201
Query: 819 GLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIR 878
++ F + W L ++L ++P+I + + K L F+ Y +A VA + +++IR
Sbjct: 202 AFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIR 261
Query: 879 TVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQ 938
TV +F ++K ++ Y+K G++ + + I G ++L++Y + A F+ G+ LV
Sbjct: 262 TVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVL 321
Query: 939 HGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAG 998
+ + +V VFF++ ++ A+ +A IF+IID++P IDS S G
Sbjct: 322 SNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQG 381
Query: 999 VTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLER 1058
++V+G++E ++V+F+YP+R I+I K L+L + S +T+ALVG+SG GKST + LL+R
Sbjct: 382 HKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQR 441
Query: 1059 FYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEII 1118
YDP G + +DG D++T + +LR+ +G+V QEP+LF +I NI YG+E T DEI
Sbjct: 442 LYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE-NVTMDEIE 500
Query: 1119 AAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSAL 1178
A ANA+ FI LP +DT VGERG QLSGGQKQRIAIAR +++NPKILLLDEATSAL
Sbjct: 501 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560
Query: 1179 DAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDG 1238
D ESE +VQ ALD+ RTT+V+AHRL+T+R AD IA G + E+G H+ELM+ G
Sbjct: 561 DTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMK-EKG 619
Query: 1239 VYASLVALHS 1248
+Y LV + +
Sbjct: 620 IYCRLVMMQT 629
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 885 bits (2287), Expect = 0.0
Identities = 510/1290 (39%), Positives = 744/1290 (57%), Gaps = 109/1290 (8%)
Query: 22 RDNKTKQK-VPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNP 80
R+ K K + LF ++D D M +GT+ A+A+G PLM + G + + F +
Sbjct: 28 REKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTG 87
Query: 81 ADAIKQVSKVSLL--------------FVYLAIGSGI--ASFLQVTCWMVTGERQAARIR 124
++ +S+L + Y +G G+ A+++QV+ W + RQ +IR
Sbjct: 88 NFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIR 147
Query: 125 SLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMA 184
+ IL+Q++ +FD + T E+ R++ D I E +G+KVG FFQ + F GF++
Sbjct: 148 QKFFHAILRQEMGWFDIKGTT-ELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVG 206
Query: 185 FIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASF 244
FI+GW+L +V++A P + ++ A + +++ S + AYA+AG V ++ GAIRTV +F
Sbjct: 207 FIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAF 266
Query: 245 TGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYN 304
G+ K +E+Y ++ A +K+ I + +G+ + + +Y LA WYGS LVI K Y
Sbjct: 267 GGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYT 326
Query: 305 GGTVMTVIIALMTGGI-------------------------------------------- 320
G MTV +++ G
Sbjct: 327 IGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDN 386
Query: 321 IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPD 380
IKG++E DV F YP+R +++I G +L V SG T ALVG SG GKST + LL+R YDP
Sbjct: 387 IKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPT 446
Query: 381 AGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLA 440
G++ IDG +++N +R +RE IG+VSQEP+LF+T+I ENI YG+ T +EI A+ A
Sbjct: 447 EGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEA 506
Query: 441 NAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESER 500
NA FI KLPQ DT+ G G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE
Sbjct: 507 NAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 566
Query: 501 IVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLI 560
VQ AL+K RTT+V+AHRL+TIRNAD+IA + G IVE+G+HS L M +G Y +L+
Sbjct: 567 EVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSEL-MKKEGIYFRLV 625
Query: 561 RLQEGDNEAEGSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRG 620
+Q ++ S + E + + D +A + + F S ++ H++
Sbjct: 626 NMQTAGSQIL-SEEFEVELSDEKAAGD--VAPNGWKARIFRNSTKKSLKSPHQN------ 676
Query: 621 LSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLF 680
D E +LD P VS ++ KLNK E P ++G + AI NG + P F +
Sbjct: 677 ------RLDEETNELD-ANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIIL 729
Query: 681 SAVISMFYKPPEQ-QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTF 739
S +I++F + ++++ +SL+F+GLG+++ LQ F FG AG L R+RS+ F
Sbjct: 730 SEMIAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAF 789
Query: 740 EKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVK 799
+ ++ Q++SWFDD +S +GA+ RL+ DA+ V+
Sbjct: 790 KAMLRQDMSWFDDHKNS---------------------------TGALSTRLATDAAQVQ 822
Query: 800 SLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADA 859
G +ALI QN + + G++I+F W L ++L + P I + GIV+MK L G +
Sbjct: 823 GATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRD 882
Query: 860 KVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSF 919
K E A ++A +A+ +IRTV S E K MY +K GP + VR + GI F S
Sbjct: 883 KKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQ 942
Query: 920 LVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAA 979
+Y + A F GS L+ +G F +V VF A+ + A+A+ ++ APD KAK SAA
Sbjct: 943 AFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAA 1002
Query: 980 SIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTI 1039
+F + + +P IDS S G+ + G + V FNYPTR ++ + + LSL + +T+
Sbjct: 1003 YLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTL 1062
Query: 1040 ALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNES 1099
ALVG SG GKSTV+ LLERFYDP +G +LLDG + K + WLR Q+G+V QEPILF+ S
Sbjct: 1063 ALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCS 1122
Query: 1100 IRANIGYGKEGGAT-EDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAI 1158
I NI YG DEI+ AA AN H FI LP Y+T VG++GTQLSGGQKQRIAI
Sbjct: 1123 IAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAI 1182
Query: 1159 ARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVI 1218
AR +++ P++LLLDEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I VI
Sbjct: 1183 ARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVI 1242
Query: 1219 KNGAVAEKGRHDELMRITDGVYASLVALHS 1248
+NG V E G H +L+ G+Y S+V + +
Sbjct: 1243 ENGKVKEHGTHQQLL-AQKGIYFSMVNIQA 1271
Score = 405 bits (1041), Expect = e-112
Identities = 241/658 (36%), Positives = 359/658 (53%), Gaps = 55/658 (8%)
Query: 616 QSLRGLSGEIVESDIEQGQLDNK---KKPKVSIWRLAKLNK----PEIPVILLGAIAAIV 668
++ R + ++ D E G + N+ KK KV++ L L + + + LG + AI
Sbjct: 4 EAARNGTARRLDGDFELGSISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIA 63
Query: 669 NGVVFPIFGFLFSAVISMFY-----------------KPPEQQRKESRFWSLLFVGLGLV 711
+G P+ +F + F P +E ++ + GLG
Sbjct: 64 HGSGLPLMMIVFGEMTDKFVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGG 123
Query: 712 TLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK** 771
LV +Q F+ +A G+ I++IR F I+ QE+ WFD
Sbjct: 124 VLVAAYIQVSFWTLAAGRQIKKIRQKFFHAILRQEMGWFDIKG----------------- 166
Query: 772 KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILA 831
TE N RL+ D S + +GD + + Q I+T AG ++ F W L
Sbjct: 167 ---TTELN---------TRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLT 214
Query: 832 FIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMD 891
+++ ++P++ + V K L FS Y +A VA +A +IRTV +F ++K ++
Sbjct: 215 LVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAFGGQNKELE 274
Query: 892 MYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVF 951
Y K K G++ + + I G +FL++Y + A F+ GS LV + T VF
Sbjct: 275 RYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVF 334
Query: 952 FALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQ 1011
F++ + A +V Q A+ +A IF+IID+ P IDS S G + + G++E
Sbjct: 335 FSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDNIKGNLEFS 394
Query: 1012 HVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDG 1071
V+F+YP+R +I+I K L+L + S +T+ALVG SG GKST + LL+R YDP G+I +DG
Sbjct: 395 DVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDG 454
Query: 1072 VDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFIS 1131
D++ F + LR+ +G+V QEP+LF+ +I NI YG+ G T DEI A ANA+ FI
Sbjct: 455 QDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGR-GNVTMDEIEKAVKEANAYDFIM 513
Query: 1132 NLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALD 1191
LP +DT VG+RG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE VQ ALD
Sbjct: 514 KLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALD 573
Query: 1192 RVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLVALHSS 1249
+ RTT+V+AHRL+TIR AD IA ++G + E+G H ELM+ +G+Y LV + ++
Sbjct: 574 KAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMK-KEGIYFRLVNMQTA 630
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 882 bits (2280), Expect = 0.0
Identities = 506/1277 (39%), Positives = 738/1277 (57%), Gaps = 108/1277 (8%)
Query: 35 LFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSS---------------N 79
LF ++D D M++GT A+A+G PLM + G + + F + N
Sbjct: 42 LFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLN 101
Query: 80 PADAIKQVSKVSLLFVYLAIGSGI--ASFLQVTCWMVTGERQAARIRSLYLKTILQQDIA 137
P +++ + Y +G G+ A+++QV+ W + RQ +IR + IL+Q++
Sbjct: 102 PGRILEE-EMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMG 160
Query: 138 FFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLA 197
+FD + T E+ R++ D I E +G+KVG FFQ + F GF++ FI+GW+L +V++A
Sbjct: 161 WFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMA 219
Query: 198 CVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSK 257
+ ++ A + +++ S + AYA+AG V ++ +GAIRTV +F G+ K +E+Y
Sbjct: 220 ITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKH 279
Query: 258 IKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMT 317
++ A +K+ I + +G+ + + +Y LA WYGS LVI K Y G MTV +++
Sbjct: 280 LENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILI 339
Query: 318 GGI--------------------------------------------IKGDIELRDVSFR 333
G IKG++E DV F
Sbjct: 340 GAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFS 399
Query: 334 YPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKN 393
YP+R +++I G +L V SG T ALVG SG GKST + LL+R YDP G + IDG +++N
Sbjct: 400 YPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRN 459
Query: 394 LQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGL 453
+R +RE IG+VSQEP+LF+T+I ENI YG+ T +EI A+ ANA FI KLPQ
Sbjct: 460 FNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKF 519
Query: 454 DTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKR 513
DT+ G G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE VQ AL+K R
Sbjct: 520 DTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGR 579
Query: 514 TTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSR 573
TT+V+AHRL+T+RNAD+IA + G IVE+G+HS L + +G Y +L+ +Q ++ S
Sbjct: 580 TTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-IKKEGIYFRLVNMQTSGSQIL-SE 637
Query: 574 KSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQG 633
+ E + L D +A + + F S ++ S H L D+E
Sbjct: 638 EFEVE-LSDE-KAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRL----------DVETN 685
Query: 634 QLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQ 693
+LD P VS ++ +LNK E P ++G + AI NG + P F + S +I++F +
Sbjct: 686 ELD-ANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDT 744
Query: 694 -QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDD 752
++++ +SL+F+GLG+ + LQ F FG AG L R+RS+ F+ ++ Q++SWFDD
Sbjct: 745 VKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDD 804
Query: 753 PSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQN 812
+S +GA+ RL+ DA+ V+ G +ALI QN
Sbjct: 805 HKNS---------------------------TGALSTRLATDAAQVQGATGTRLALIAQN 837
Query: 813 ISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVAND 872
+ + G++I+F W L ++L + P I + GIV+MK L G + K E A ++A +
Sbjct: 838 TANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATE 897
Query: 873 AVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYI 932
A+ +IRTV S E K MY +K GP + VR + GI F S +Y + A F
Sbjct: 898 AIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRF 957
Query: 933 GSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDID 992
GS L+ +G F +V VF A+ + A+A+ ++ APD KAK SAA +F + + +P ID
Sbjct: 958 GSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLID 1017
Query: 993 SSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTV 1052
S S G+ + G + V FNYPTR ++ + + LSL + +T+ALVG SG GKSTV
Sbjct: 1018 SYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1077
Query: 1053 ISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGG- 1111
+ LLERFYDP +G +LLDG + K + WLR Q+G+V QEPILF+ SI NI YG
Sbjct: 1078 VQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRV 1137
Query: 1112 ATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLL 1171
++DEI+ AA AN H FI LP Y+T VG++GTQLSGGQKQRIAIAR +++ P++LLL
Sbjct: 1138 VSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLL 1197
Query: 1172 DEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDE 1231
DEATSALD ESE++VQEALD+ RT +V+AHRL+TI+ AD I VI NG V E G H +
Sbjct: 1198 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQ 1257
Query: 1232 LMRITDGVYASLVALHS 1248
L+ G+Y S+V + +
Sbjct: 1258 LL-AQKGIYFSMVNIQA 1273
Score = 399 bits (1025), Expect = e-110
Identities = 239/658 (36%), Positives = 357/658 (53%), Gaps = 55/658 (8%)
Query: 616 QSLRGLSGEIVESDIEQGQLDNK---KKPKVSIWRLAKLNK----PEIPVILLGAIAAIV 668
++ R + ++ D E G + N+ KK KV++ L + + +LLG AI
Sbjct: 4 EAARNGTARRLDGDFELGSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIA 63
Query: 669 NGVVFPIFGFLFSAVISMFY-----------------KPPEQQRKESRFWSLLFVGLGLV 711
+G P+ +F + F P +E ++ + GLG
Sbjct: 64 HGSGLPLMMIVFGEMTDKFVDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGG 123
Query: 712 TLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK** 771
L+ +Q F+ +A G+ I +IR F I+ QE+ WFD
Sbjct: 124 VLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDIKG----------------- 166
Query: 772 KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILA 831
TE N RL+ D S + +GD + + Q I+T AG ++ F W L
Sbjct: 167 ---TTELN---------TRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLT 214
Query: 832 FIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMD 891
+++ +T ++ + V K L FS Y +A VA +A+ +IRTV +F ++K ++
Sbjct: 215 LVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELE 274
Query: 892 MYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVF 951
Y K K G++ + + I G +FL++Y + A F+ GS LV + T VF
Sbjct: 275 RYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVF 334
Query: 952 FALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQ 1011
F++ + A +V Q A+ +A IF+IID+ P IDS S G +++ G++E
Sbjct: 335 FSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFS 394
Query: 1012 HVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDG 1071
V+F+YP+R +I+I K L+L + S +T+ALVG SG GKST + LL+R YDP G I +DG
Sbjct: 395 DVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDG 454
Query: 1072 VDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFIS 1131
D++ F + LR+ +G+V QEP+LF+ +I NI YG+ G T DEI A ANA+ FI
Sbjct: 455 QDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGR-GNVTMDEIKKAVKEANAYDFIM 513
Query: 1132 NLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALD 1191
LP +DT VG+RG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE VQ ALD
Sbjct: 514 KLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALD 573
Query: 1192 RVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLVALHSS 1249
+ RTT+V+AHRL+T+R AD IA ++G + E+G H EL++ +G+Y LV + +S
Sbjct: 574 KAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIK-KEGIYFRLVNMQTS 630
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 880 bits (2274), Expect = 0.0
Identities = 503/1299 (38%), Positives = 749/1299 (56%), Gaps = 121/1299 (9%)
Query: 20 GIRDNKTKQKVP---FYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFG 76
G + K K+K P + +F +AD LD M +GT++A+ +G PL+ L G + ++F
Sbjct: 19 GKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFT 78
Query: 77 SSNPADAIKQVSKVSLL-------------------FVYLAIGSG--IASFLQVTCWMVT 115
S + + ++ S + + Y IG+G I +++QV+ W +
Sbjct: 79 PSRDPHSDRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLA 138
Query: 116 GERQAARIRSLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLAS 175
RQ +IR + I+ Q+I +FD + GE+ R++ D I + +G+K+G FFQ +
Sbjct: 139 AGRQIHKIRQKFFHAIMNQEIGWFDVN-DAGELNTRLTDDVSKINDGIGDKLGMFFQSIT 197
Query: 176 NFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTV 235
F GF++ FI GW+L +V+LA P + ++ A + V+ +++ AYA+AG V ++ +
Sbjct: 198 TFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVL 257
Query: 236 GAIRTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGS 295
AIRTV +F G+KK +E+YN ++ A +K+ I + IG+ + + +Y LA WYG+
Sbjct: 258 AAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGT 317
Query: 296 KLVIEKGYNGGTVMTVIIALMTGGI----------------------------------- 320
LV+ Y+ G V+TV +++ G
Sbjct: 318 SLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSF 377
Query: 321 ---------IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVIS 371
I G++E ++V F YP+R +V+I G +L V SG T ALVG SG GKST +
Sbjct: 378 STKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQ 437
Query: 372 LLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGATDE 431
LL+R YDP GEV IDG +++ + +R++RE IG+VSQEP+LF T+I ENI YG+E T +
Sbjct: 438 LLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 497
Query: 432 EITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEAT 491
EI A+ ANA FI KLP DT+ G+ G QLSGGQKQRIAIARA+++NPKILLLDEAT
Sbjct: 498 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 557
Query: 492 SALDAESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMD 551
SALD ESE +VQ AL+K RTT+V+AHRL+T+RNAD+IA G IVE+G H L M
Sbjct: 558 SALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MK 616
Query: 552 PDGAYSQLIRLQEGDNEAE-GSRKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSV 610
G Y +L+ Q NE E G+ E+ + S + S R S RSI +
Sbjct: 617 EKGIYFKLVMTQTRGNEIEPGNNAYESQSDTGASELTSEESKSPLIRRSIRRSIHR---- 672
Query: 611 SHRHSQSLRGLSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNG 670
R Q R S E V+ D+ P VS W++ KLN E P +++G + A++NG
Sbjct: 673 --RQDQERRLSSKEDVDEDV----------PMVSFWQILKLNISEWPYLVVGVLCAVING 720
Query: 671 VVFPIFGFLFSAVISMFYKPPEQQRKE--SRFWSLLFVGLGLVTLVILPLQNFFFGIAGG 728
+ P+F +FS ++ +F + + + K+ +SLLF+ +G+++ V Q F FG AG
Sbjct: 721 CIQPVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGE 780
Query: 729 KLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVG 788
L +R+R + F+ ++ Q+ISWFDD + +G++
Sbjct: 781 ILTKRLRYMVFKSMLRQDISWFDD---------------------------HKNTTGSLT 813
Query: 789 ARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTA--NWILAFIVLVLTPMILMQGI 846
RL+ DAS VK +G +A++ QN++ + G++++ W L +++V+ P+I++ GI
Sbjct: 814 TRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGI 873
Query: 847 VQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVR 906
++MK L G + K E + ++A +A+ + RTV S E K MY++ P + ++
Sbjct: 874 IEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALK 933
Query: 907 LGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTT 966
V GI F + ++Y + A F G+ LV TF V VF A+ A+A T++
Sbjct: 934 KAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSS 993
Query: 967 LAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIF 1026
APD KAK SA+ I II+ P+IDS S G+ + G+++ V FNYPTRP+I +
Sbjct: 994 FAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVL 1053
Query: 1027 KDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQM 1086
+ LS + +T+ LVG SG GKSTV+ LLERFY+P +G + LDG ++K + +R +
Sbjct: 1054 QGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVR-AL 1112
Query: 1087 GLVGQEPILFNESIRANIGYGKEGG-ATEDEIIAAANAANAHSFISNLPDGYDTSVGERG 1145
G+V QEPILF+ SI NI YG + +EI+ AA AN H FI +LP+ Y+T VG++G
Sbjct: 1113 GIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKG 1172
Query: 1146 TQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHR 1205
TQLSGGQKQRIAIAR +++ P ILLLDEATSALD ESE++VQEALD+ RT VV+AHR
Sbjct: 1173 TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHR 1232
Query: 1206 LTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLV 1244
L+TI+ AD I VI+NG V E G H +L+ G+Y S+V
Sbjct: 1233 LSTIQNADLIVVIQNGQVKEHGTHQQLL-AQKGIYFSMV 1270
Score = 407 bits (1045), Expect = e-112
Identities = 230/651 (35%), Positives = 365/651 (55%), Gaps = 57/651 (8%)
Query: 620 GLSGEIVESDIEQGQLDNK---KKPKVSIWRLAKL-NKPEIPVILLGAIAAIVNGVVFPI 675
GL+G ++ + G+ K KKP V I+ + + + + + LG +AAI++G + P+
Sbjct: 6 GLNGRADKNFSKMGKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPL 65
Query: 676 FGFLFSAVISMFY--KPPEQQR--------------------KESRFWSLLFVGLGLVTL 713
+F + F + P R ++ ++ + G+G L
Sbjct: 66 LMLVFGYMTDSFTPSRDPHSDRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVL 125
Query: 714 VILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KN 773
++ +Q + +A G+ I +IR F I++QEI WFD
Sbjct: 126 IVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFD---------------------- 163
Query: 774 YETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFI 833
+ +G + RL+ D S + +GD + + Q+I+T AG +I F + W L +
Sbjct: 164 -------VNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLV 216
Query: 834 VLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMY 893
+L ++P+I + + K L F+ Y +A VA + +++IRTV +F + K ++ Y
Sbjct: 217 ILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERY 276
Query: 894 SKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFA 953
+K + G++ + + I G ++L++Y + A F+ G+ LV + + +V VFF+
Sbjct: 277 NKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFS 336
Query: 954 LTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHV 1013
+ + ++ A+ +A IF+IID++P IDS S G ++++G++E ++V
Sbjct: 337 ILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNV 396
Query: 1014 NFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVD 1073
FNYP+R +++I K L+L + S +T+ALVG SG GKST + LL+R YDP G + +DG D
Sbjct: 397 YFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQD 456
Query: 1074 LKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNL 1133
++T + +LR+ +G+V QEP+LF +I NI YG+E T DEI A ANA+ FI L
Sbjct: 457 IRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRE-NVTMDEIEKAVKEANAYDFIMKL 515
Query: 1134 PDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRV 1193
P +DT VGERG QLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE +VQ ALD+
Sbjct: 516 PHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKA 575
Query: 1194 SVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLV 1244
RTT+V+AHRL+T+R AD IA G + E+G H+ELM+ G+Y LV
Sbjct: 576 REGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMK-EKGIYFKLV 625
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 818 bits (2113), Expect = 0.0
Identities = 495/1331 (37%), Positives = 728/1331 (54%), Gaps = 126/1331 (9%)
Query: 3 ENPNVHDNSSSSPTQQHGIRDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASP 62
E+ H+N S Q + +V F+ LF F+ D LM +G++ A+ +G+A P
Sbjct: 21 ESDGFHNNDKKSRLQD---KKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQP 77
Query: 63 LMTLFLGNVINAF------------------------------------GSSNPADAIKQ 86
M + G + + F S D +
Sbjct: 78 GMIIVFGILTDIFVEYDIERQELSIPGKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSE 137
Query: 87 VSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETNTG 146
V K S ++ + + I + Q+ W++TG RQ ++R Y + I++ +I +FD T+ G
Sbjct: 138 VIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDC-TSVG 196
Query: 147 EVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAG 206
E+ R S D I EA+ +++ F Q S G ++ F +GW+L +V+LA P + +
Sbjct: 197 ELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGA 256
Query: 207 AFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTTMV 266
A + + +AK + AYA+AG++ D+ + +IRTVA+F GE K +E+Y + A +
Sbjct: 257 AVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGI 316
Query: 267 KQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKG-YNGGTV----MTVIIALMTGGI- 320
+G+V GF G + + F Y LA WYGS+LV+++G Y GT+ + VIIA M G
Sbjct: 317 WKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNA 376
Query: 321 ---------------------------------------IKGDIELRDVSFRYPARPDVQ 341
IKG+IE +V+F YP+RP+V+
Sbjct: 377 SSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVK 436
Query: 342 IFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIRE 401
I + S+ + G TTA VG SG+GKST + L++RFYDP G V +DG ++++L +RW+R+
Sbjct: 437 ILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRD 496
Query: 402 QIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQNG 461
QIG+V QEP+LF+T+I ENI G+E AT E+I A ANA FI LPQ DT+ G+ G
Sbjct: 497 QIGIVEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGG 556
Query: 462 TQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVAHR 521
Q+SGGQKQR+AIARA+++ PKILLLD ATSALD ESE VQ AL KI T + VAHR
Sbjct: 557 GQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHR 616
Query: 522 LTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEA------EGSRKS 575
L+T+R+AD+I + G VERGTH L ++ G Y L+ LQ ++ +G +
Sbjct: 617 LSTVRSADVIIGFEHGTAVERGTHEEL-LERKGVYFMLVTLQSQEDNTHKETGIKGKDTT 675
Query: 576 EADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQGQL 635
E D + S+ S + + RS SQ S +SH ++ G E + L
Sbjct: 676 EGDTPERTFSRGSYQ--DSLRASIRQRSKSQLSHLSHEPPLAI-GDHKSSYEDRKDNDVL 732
Query: 636 DNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMF-YKPPEQQ 694
+ +P + R+ K N E P IL+GA+ A +NG V PI+ LFS ++ F EQQ
Sbjct: 733 VEEVEP-APVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQ 791
Query: 695 RKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPS 754
R E L FV LG V+L LQ + F +G L +R+R F+ ++ Q+I WFDD
Sbjct: 792 RSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLK 851
Query: 755 HSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNIS 814
++ G + RL+ DAS V+ G + ++V + +
Sbjct: 852 NN---------------------------PGVLTTRLATDASQVQGATGSQVGMMVNSFT 884
Query: 815 TVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAV 874
+ ++IAF NW L+ ++ V P + + G VQ K L GF++ K + E+A Q+ N+A+
Sbjct: 885 NIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEAL 944
Query: 875 SSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGS 934
S+IRTVA E + + + + K +R V G+ + S + + N+ + G
Sbjct: 945 SNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGG 1004
Query: 935 VLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSS 994
L+ + F+ VFRV ++ M+A AV +T + P KAK SAA F+++D KP ID
Sbjct: 1005 YLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVY 1064
Query: 995 SNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVIS 1054
S AG + G I+ F YP+RPDIQ+ LS+S+ +T+A VG SG GKST I
Sbjct: 1065 SGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQ 1124
Query: 1055 LLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYG-KEGGAT 1113
LLERFYDP+ G +++DG D K + +LR +G+V QEP+LF+ SI NI YG +
Sbjct: 1125 LLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEIS 1184
Query: 1114 EDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDE 1173
+ IAAA A H F+ +LP+ Y+T+VG +G+QLS G+KQRIAIAR ++++PKILLLDE
Sbjct: 1185 VERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDE 1244
Query: 1174 ATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELM 1233
ATSALD ESE+ VQ ALD+ RT +V+AHRL+TI+ +D IAV+ G V EKG H +LM
Sbjct: 1245 ATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLM 1304
Query: 1234 RITDGVYASLV 1244
G Y LV
Sbjct: 1305 D-QKGAYYKLV 1314
Score = 361 bits (926), Expect = 8e-99
Identities = 202/550 (36%), Positives = 319/550 (57%), Gaps = 34/550 (6%)
Query: 701 WSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVI 760
+S ++ G+G+ L++ Q + I G + I ++R F +I+ EI WFD S
Sbjct: 141 FSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTS------ 194
Query: 761 QNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGL 820
G + +R S D + + + D MAL +Q +ST ++GL
Sbjct: 195 -----------------------VGELNSRFSDDINKIDEAIADQMALFLQRLSTALSGL 231
Query: 821 VIAFTANWILAFIVLVLTPMI-LMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRT 879
++ F W L ++L ++P+I + ++ + K + K Y +A +A++ +SSIRT
Sbjct: 232 LLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKA-YAKAGSIADEVLSSIRT 290
Query: 880 VASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLV-Q 938
VA+F E+K ++ Y K + + G+ G+V G G + +++ A F+ GS LV
Sbjct: 291 VAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLD 350
Query: 939 HGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAG 998
G+ T + ++F + + A+ + ++ + +A+SIF+ ID +P +D S G
Sbjct: 351 EGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDG 410
Query: 999 VTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLER 1058
+ + G+IE +V F+YP+RP+++I +LS+ I +T A VG SG+GKST + L++R
Sbjct: 411 YKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQR 470
Query: 1059 FYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEII 1118
FYDP G + LDG D+++ + WLR Q+G+V QEP+LF+ +I NI G+E AT ++I+
Sbjct: 471 FYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGRE-EATMEDIV 529
Query: 1119 AAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSAL 1178
AA ANA++FI LP +DT VGE G Q+SGGQKQR+AIAR +++ PKILLLD ATSAL
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSAL 589
Query: 1179 DAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDG 1238
D ESE VQ AL+++ T + VAHRL+T+R AD I ++G E+G H+EL+ G
Sbjct: 590 DNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLE-RKG 648
Query: 1239 VYASLVALHS 1248
VY LV L S
Sbjct: 649 VYFMLVTLQS 658
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 817 bits (2111), Expect = 0.0
Identities = 495/1334 (37%), Positives = 737/1334 (55%), Gaps = 132/1334 (9%)
Query: 3 ENPNVHDNSSSSPTQQHGIRDNKTKQ---KVPFYMLFNFADHLDVTLMIIGTISAVANGL 59
E+ H+N S Q +K K+ +V F+ LF F+ D+ LM++G + A+ +G+
Sbjct: 21 ESDGSHNNDKKSRLQ------DKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGM 74
Query: 60 ASPLMTLFLG-------------------------NVINAFGSS-----------NPADA 83
A P + + G N I SS D
Sbjct: 75 AQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDI 134
Query: 84 IKQVSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTET 143
++ K S ++ + + I + Q+ W++TG RQ R+R +Y + I++ +I +FD T
Sbjct: 135 ESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDC-T 193
Query: 144 NTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVA 203
+ GE+ R + D I +A+ +++ F Q S G ++ F +GW+L +V+LA P +
Sbjct: 194 SVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIG 253
Query: 204 VAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYT 263
+ A + + +AK + AYA+AG++ D+ + +IRTVA+F GE K +E+Y + A
Sbjct: 254 IGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQR 313
Query: 264 TMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVI-EKGYNGGTVMTVIIALMTGGI-- 320
+ +G+V GF G + + F Y LA WYGS LV+ E+ Y GT++ + + ++ +
Sbjct: 314 WGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNI 373
Query: 321 ------------------------------------------IKGDIELRDVSFRYPARP 338
IKG+IE +V+F YP+RP
Sbjct: 374 GHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 339 DVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRW 398
DV+I D S+ + G TTALVG SG+GKST + L++RFYDP G V +DG ++++L +RW
Sbjct: 434 DVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRW 493
Query: 399 IREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAG 458
+R+QIG+V QEP+LF+T+I ENI +G+E AT E+I A ANA FI LPQ DT+ G
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVG 553
Query: 459 QNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVV 518
+ G Q+SGGQKQR+AIARA+++NPKILLLD ATSALD ESE VQEAL KI T + V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISV 613
Query: 519 AHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQ-EGDNEAE-----GS 572
AHRL+T+R AD+I + G VERGTH L ++ G Y L+ LQ +GDN + G
Sbjct: 614 AHRLSTVRAADVIIGFEHGVAVERGTHEEL-LERKGVYFMLVTLQSQGDNAHKETSIMGK 672
Query: 573 RKSEADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQ 632
+E L + S+ S + + RS SQ S ++H ++ +S +
Sbjct: 673 DATEGGTLERTFSRGSYR--DSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSK-DN 729
Query: 633 GQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMF-YKPP 691
L + +P + R+ K N PE IL+G+++A +NG V PI+ LFS ++ F
Sbjct: 730 DVLVEEVEP-APVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDK 788
Query: 692 EQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFD 751
EQQR E L FV LG V++ LQ + F +G L +R+R F+ ++ Q+I WFD
Sbjct: 789 EQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFD 848
Query: 752 DPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQ 811
D ++ G + RL+ DAS V+ G + ++V
Sbjct: 849 DLRNN---------------------------PGVLTTRLATDASQVQGATGSQVGMMVN 881
Query: 812 NISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVAN 871
+ + +IA L+IAF +W L+ I+ + P + + G VQ K L GF++ K E+A Q+ +
Sbjct: 882 SFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITS 941
Query: 872 DAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFY 931
+A+S+IRTVA E + + + + K VR + G+ F S + + N+ +
Sbjct: 942 EALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYR 1001
Query: 932 IGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDI 991
G L+ + F+ VFRV ++ ++A AV +T + P KAK SAA F+++D KP I
Sbjct: 1002 YGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPI 1061
Query: 992 DSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKST 1051
+ S AG + G I+ F YP+RPDIQ+ LS+S+ +T+A VG SG GKST
Sbjct: 1062 NVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKST 1121
Query: 1052 VISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGG 1111
I LLERFYDP+ G +++DG D K + +LR +G+V QEP+LF+ SI NI YG
Sbjct: 1122 SIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTK 1181
Query: 1112 ATEDE-IIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILL 1170
E IAAA A H F+ +LP+ Y+T+VG +G+QLS G+KQRIAIAR ++++PKILL
Sbjct: 1182 EISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILL 1241
Query: 1171 LDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHD 1230
LDEATSALD ESE+ VQ ALD+ RT +V+AHRL+TI+ +D IAV+ G V EKG H+
Sbjct: 1242 LDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHE 1301
Query: 1231 ELMRITDGVYASLV 1244
+LM G Y LV
Sbjct: 1302 KLM-AQKGAYYKLV 1314
Score = 365 bits (936), Expect = e-100
Identities = 227/680 (33%), Positives = 365/680 (53%), Gaps = 82/680 (12%)
Query: 608 SSVSHRHSQSLRGLSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAI 667
S SH + + R L ++ E DI G + ++R + + +I ++L+G + A+
Sbjct: 22 SDGSHNNDKKSR-LQDKMKEGDIRVGFFE--------LFRFS--SSKDIWLMLMGGVCAL 70
Query: 668 VNGVVFPIFGFLFSAVISMFYKPP-EQQRKE---------------SRF----------- 700
++G+ P +F + +F K E+Q E S F
Sbjct: 71 LHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCG 130
Query: 701 ----------WSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWF 750
+S ++ G+G+ L++ Q + I G + I R+R + F +I+ EI WF
Sbjct: 131 LVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWF 190
Query: 751 DDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIV 810
D S G + +R + D + + D +A +
Sbjct: 191 DCTS-----------------------------VGELNSRFADDIEKINDAIADQLAHFL 221
Query: 811 QNISTVIAGLVIAFTANWILAFIVLVLTPMI-LMQGIVQMKFLKGFSADAKVMYEEASQV 869
Q +ST + GL++ F W L ++L ++P+I + ++ + K + K Y +A +
Sbjct: 222 QRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKA-YAKAGSI 280
Query: 870 ANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFI 929
A++ +SSIRTVA+F E+K ++ Y K + + G+ G+V G G + +++ A
Sbjct: 281 ADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALA 340
Query: 930 FYIGSVLV-QHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSK 988
F+ GS LV + T + ++F + + A+ + ++ + +A +IF+ ID +
Sbjct: 341 FWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQ 400
Query: 989 PDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSG 1048
P ID S G + + G+IE +V F+YP+RPD++I +LS+ I +T ALVG SG+G
Sbjct: 401 PVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAG 460
Query: 1049 KSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGK 1108
KST + L++RFYDP G + LDG D+++ + WLR Q+G+V QEP+LF+ +I NI +G+
Sbjct: 461 KSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGR 520
Query: 1109 EGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKI 1168
E AT ++I+ AA ANA++FI LP +DT VGE G Q+SGGQKQR+AIAR +++NPKI
Sbjct: 521 E-DATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKI 579
Query: 1169 LLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGR 1228
LLLD ATSALD ESE VQEAL+++ T + VAHRL+T+R AD I ++G E+G
Sbjct: 580 LLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGT 639
Query: 1229 HDELMRITDGVYASLVALHS 1248
H+EL+ GVY LV L S
Sbjct: 640 HEELLE-RKGVYFMLVTLQS 658
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 814 bits (2103), Expect = 0.0
Identities = 475/1335 (35%), Positives = 734/1335 (54%), Gaps = 121/1335 (9%)
Query: 3 ENPNVHDNSSSSPTQQHGIRDNKTKQ--KVPFYMLFNFADHLDVTLMIIGTISAVANGLA 60
EN + S + ++ ++D K +V F+ LF F+ D+ LM +G++ A +G+A
Sbjct: 16 ENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIA 75
Query: 61 SPLMTLFLGNVINAF-------------GSSNPADAI----------------------- 84
P + L G + + F G + + I
Sbjct: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
Query: 85 KQVSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETN 144
++ K + + +A+ I ++Q+ W++ RQ ++R Y + I++ +I +FD +
Sbjct: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS- 194
Query: 145 TGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAV 204
GE+ R S D I +A+ +++ F Q ++ GF++ F +GW+L +V+++ P + +
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 205 AGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTT 264
A + + ++K + AYA+AG V D+ + ++RTVA+F GEK+ +E+Y + A
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 265 MVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKG-YNGGTVMTVIIALMTGGI--- 320
+++GIV GF G + + F Y +A WYGS LV+++G Y GT++ + ++++ G +
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 321 -----------------------------------------IKGDIELRDVSFRYPARPD 339
IKG+IE +V+F YP+RP+
Sbjct: 375 NASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPE 434
Query: 340 VQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWI 399
V+I + ++ + G TALVG SG+GKST + L++RFYDP G V +DG ++++L ++W+
Sbjct: 435 VKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWL 494
Query: 400 REQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQ 459
R+QIG+V QEP+LF+T+I ENI YG+E AT E+I A ANA FI LPQ DT+ G+
Sbjct: 495 RDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 460 NGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVA 519
G Q+SGGQKQR+AIARA+++NPKILLLD ATSALD ESE +VQE L KI T + VA
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVA 614
Query: 520 HRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSR----KS 575
HRL+T+R AD I + G VERGTH L ++ G Y L+ LQ N+A +
Sbjct: 615 HRLSTVRAADTIIGFEHGTAVERGTHEEL-LERKGVYFTLVTLQSQGNQALNEEDIKDAT 673
Query: 576 EADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQGQL 635
E D L + S+ S + + RS SQ S + H ++ E ++
Sbjct: 674 EDDMLARTFSRGSYQ--DSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIP 731
Query: 636 DNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKP-PEQQ 694
++ + R+ K + PE P +L+G++ A VNG V P++ FLFS ++ F P E+Q
Sbjct: 732 VQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQ 791
Query: 695 RKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPS 754
R + LLFV +G V+L LQ + F +G L +R+R F ++ Q+I+WFDD
Sbjct: 792 RSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLR 851
Query: 755 HSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNIS 814
+S GA+ RL+ DAS V+ G + +IV + +
Sbjct: 852 NS---------------------------PGALTTRLATDASQVQGAAGSQIGMIVNSFT 884
Query: 815 TVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAV 874
V ++IAF+ +W L+ ++L P + + G Q + L GF++ K E Q+ N+A+
Sbjct: 885 NVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEAL 944
Query: 875 SSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGS 934
S+IRTVA E + ++ + P K ++ + G F + +++ N+ + G
Sbjct: 945 SNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGG 1004
Query: 935 VLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSS 994
L+ + F+ VFRV A+ ++A A+ + + P KAK SAA F+++D +P I
Sbjct: 1005 YLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVY 1064
Query: 995 SNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVIS 1054
+ AG + G I+ F YP+RPD Q+ LS+SI +T+A VG SG GKST I
Sbjct: 1065 NTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQ 1124
Query: 1055 LLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATE 1114
LLERFYDP+ G++++DG D K + +LR +G+V QEP+LF SI NI YG
Sbjct: 1125 LLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIP 1184
Query: 1115 -DEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDE 1173
+ +IAAA A H F+ +LP+ Y+T+VG +G+QLS G+KQRIAIAR ++++PKILLLDE
Sbjct: 1185 MERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDE 1244
Query: 1174 ATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELM 1233
ATSALD ESE+ VQ ALD+ RT +V+AHRL+TI+ AD IAV+ G V EKG H+ELM
Sbjct: 1245 ATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELM 1304
Query: 1234 RITDGVYASLVALHS 1248
G Y LV S
Sbjct: 1305 -AQKGAYYKLVTTGS 1318
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 792 bits (2045), Expect = 0.0
Identities = 473/1334 (35%), Positives = 729/1334 (54%), Gaps = 119/1334 (8%)
Query: 3 ENPNVHDNSSSSPTQQHGIRDNKTKQ--KVPFYMLFNFADHLDVTLMIIGTISAVANGLA 60
EN + S + ++ ++D K ++ F+ LF F+ D+ LM +G++ A +G+A
Sbjct: 16 ENHGFESDGSYNNEKKSRLQDKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIA 75
Query: 61 SPLMTLFLGNV----------------------------INAFGSSNPADAIK----QVS 88
P + L G + IN+ + N + + +
Sbjct: 76 QPGVLLIFGTMTDVFIDYDTELQELKIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDIE 135
Query: 89 KVSLLFVYLAIGSGIA----SFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETN 144
+ F G GIA ++Q+ W + Q ++R Y + I++ I + D +
Sbjct: 136 SEMIRFAGYYAGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNS- 194
Query: 145 TGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAV 204
G++ S D I ++ +++ F Q ++ GF++ F + W+L +V+++ P + +
Sbjct: 195 VGKLNTPFSVDFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGL 254
Query: 205 AGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTT 264
A + + ++K + AYA+AG+V D+ + ++RTVA+F GEKK +E+Y + A
Sbjct: 255 GAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRW 314
Query: 265 MVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKG-YNGGTVMTVIIALMTGGI--- 320
+++GIV GF G + + F Y LA WYGSKLV+E+G Y+ G ++ + ++++ G +
Sbjct: 315 GIRKGIVMGFFTGYMWCLIFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLG 374
Query: 321 -----------------------------------------IKGDIELRDVSFRYPARPD 339
IKG+IE +V+F YP+RP+
Sbjct: 375 NASPCLEAFAAGRAAASSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPE 434
Query: 340 VQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWI 399
V+I + S+ + G TALVG SG+GKST + L+ RFY P G V ++ ++++ ++W+
Sbjct: 435 VKILNNLSMVIKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWL 494
Query: 400 REQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQ 459
R QIG+V QEP+LF +I E I YG+E AT E++ A ANA FI LPQ DT+ G+
Sbjct: 495 RNQIGIVEQEPVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 460 NGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVA 519
G Q+SGGQKQR+AIARA+++NPKILLLD ATSALD ESE +VQEAL K T V VA
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVA 614
Query: 520 HRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSRKSEADK 579
HR TIR AD+I + G VERGT L ++ G Y L+ LQ N+ + ++E D
Sbjct: 615 HRPATIRTADVIIGCEHGAAVERGTEEEL-LERKGVYFALVTLQSQRNQGD-QEENEKDA 672
Query: 580 LGDNLNIDSHMAGS---STQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQGQLD 636
D++ + G+ S + + RS SQ S ++H ++ E ++
Sbjct: 673 TEDDIPEKTFSRGNYQDSLRASLRQRSKSQLSYLAHEPPMAVEDHKSTHEEDRKDKDLPA 732
Query: 637 NKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKP-PEQQR 695
+ S+ R+ KLN PE P +LLG++ A VNG V P++ FLFS ++ F P E+QR
Sbjct: 733 QEDIEPASVRRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQR 792
Query: 696 KESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSH 755
+ LLFV LG V+ LQ + F +G L +R+R F ++ Q+I WFDD +
Sbjct: 793 SQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRN 852
Query: 756 SRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNIST 815
S GA+ RL+ DAS V+ G + ++V + +
Sbjct: 853 S---------------------------PGALTTRLATDASQVQGATGSQIGMMVNSFTN 885
Query: 816 VIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVS 875
V ++IAF +W L ++ P + + G +Q K L GF++ K E+A Q+ ++A+S
Sbjct: 886 VTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEALS 945
Query: 876 SIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSV 935
+IRTVA E K ++ + + P K ++ V G+ FG S + + N+ + G
Sbjct: 946 NIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGY 1005
Query: 936 LVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSS 995
L+ + F+ VFRV A+ ++A A+ + ++ P KAK SAA F+++D +P I+ S
Sbjct: 1006 LISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYS 1065
Query: 996 NAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISL 1055
+AG + G I+ F YP+RPDIQ+ LS+S+ +T+A VG SG GKST I L
Sbjct: 1066 SAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQL 1125
Query: 1056 LERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATE- 1114
LERFYDP+ G++++DG D + + +LR +G+V QEP+LF SI+ NI YG
Sbjct: 1126 LERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPM 1185
Query: 1115 DEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEA 1174
+ IIAAA A H F+ +LP+ Y+T+VG +G+QLS G+KQRIAIAR ++++PKILLLDEA
Sbjct: 1186 ERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEA 1245
Query: 1175 TSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMR 1234
TSALD ESE+ VQ ALD+ RT +V+AHRL+TI+ +D IAV+ G V EKG H+ELM
Sbjct: 1246 TSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELM- 1304
Query: 1235 ITDGVYASLVALHS 1248
+ G Y LV S
Sbjct: 1305 VQKGAYYKLVTTGS 1318
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein A)
Length = 1321
Score = 773 bits (1996), Expect = 0.0
Identities = 454/1310 (34%), Positives = 713/1310 (53%), Gaps = 121/1310 (9%)
Query: 3 ENPNVHDNSSSSPTQQHGIRDNKTK--QKVPFYMLFNFADHLDVTLMIIGTISAVANGLA 60
E N+ N T RD K + KV L+ + L+ L+ IGT+ AV G
Sbjct: 36 EGDNIDSNGEIKIT-----RDAKEEVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAG 90
Query: 61 SPLMTLFLGNVINAF----------GSS--------NPADAIKQVSKVSLLFVYLAIGSG 102
PLM++ G V AF GS+ D V V + + +G
Sbjct: 91 LPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMW 150
Query: 103 IASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEA 162
A + VTC++ E+ R+R ++K+IL+Q+I++FDT ++G + ++ + ++E
Sbjct: 151 AAGQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFDTN-HSGTLATKLFDNLERVKEG 209
Query: 163 MGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQI 222
G+K+G FQ S F GF++AF W+L +V+LA P A+ G ++ M+ + R +
Sbjct: 210 TGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETL 269
Query: 223 AYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFI 282
YA+AG VV++T+ +IRTV S G + +E+Y++ ++ A V +G+ G G +
Sbjct: 270 RYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQAS 329
Query: 283 AFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTGGI---------------------- 320
F ++ LA + G V + N G ++T ++M G +
Sbjct: 330 NFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGI 389
Query: 321 ----------------------IKGDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTAL 358
IKGDI + +V F YP+RPDV I G +L V +G T AL
Sbjct: 390 YEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVAL 449
Query: 359 VGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIR 418
VG SG GKST+ISLL R+YD G++ IDGV+++++ L ++R+ + +VSQEP LF +I
Sbjct: 450 VGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIE 509
Query: 419 ENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAI 478
ENI+ GKEG T EE+ A +ANA+KFI LP G +T+ G GTQLSGGQKQRIAIARA+
Sbjct: 510 ENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARAL 569
Query: 479 LKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGK 538
++NPKILLLDEATSALDAESE IVQ+AL+K RTT+++AHRL+TIRNAD+I + G+
Sbjct: 570 VRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQ 629
Query: 539 IVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSRKSEADKLGDNLNIDSHMAGSSTQRT 598
+VE G H L M G Y L+ Q + + + + + + ++ +A +++
Sbjct: 630 VVEVGDHRAL-MAQQGLYYDLVTAQTFTDAVDSAAEGKFSR-------ENSVARQTSEHE 681
Query: 599 SFVRSISQTSSVSHRHSQSLRG--LSGEIVESDIE----------QGQLDNKKKPKVSIW 646
R S+ + +R S G +G +++ E + +L+ K +++
Sbjct: 682 GLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALSRLKQELEENNAQKTNLF 741
Query: 647 RLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQQRKESRFWSLLFV 706
+ +P + +G A + G ++P + F++ +++F P + FW+L+F+
Sbjct: 742 EILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAGNPADFLSQGHFWALMFL 801
Query: 707 GLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYF 766
L + L FF GIA L +R+ F ++ Q I +FD P ++
Sbjct: 802 VLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNA---------- 851
Query: 767 MTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTA 826
SG + RL+ D +++ + + ++ + +++AG+ +AF
Sbjct: 852 -----------------SGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFY 894
Query: 827 NWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAE 886
W +A +++ + P++ ++ + G + + + ++ ++A +A+ ++RTV + E
Sbjct: 895 GWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALARE 954
Query: 887 SKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATF-- 944
+ + +K P K+ ++ + G+ +GC+ VLY N + +G L+ T
Sbjct: 955 DTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQP 1014
Query: 945 TEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETV 1004
V RV +A+T++ + T+ P+ KA + IF ++ IDS S AG ++ +
Sbjct: 1015 MRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAG-EKKKL 1073
Query: 1005 VGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNS 1064
G + ++V F YP RP+I+I K LS S+ +T+ALVG SG GKSTV++LLERFYD
Sbjct: 1074 YGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLG 1133
Query: 1065 GRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKE-GGATEDEIIAAANA 1123
G I +DG ++KT R Q+ +V QEP LF+ SI NI YG + T ++ AA
Sbjct: 1134 GEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARL 1193
Query: 1124 ANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESE 1183
AN H+FI+ LP+G++T VG+RGTQLSGGQKQRIAIAR +++NPKILLLDEATSALD ESE
Sbjct: 1194 ANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 1253
Query: 1184 RIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELM 1233
++VQEALDR RT +V+AHRL T+ AD IAV+ NG + EKG H +LM
Sbjct: 1254 KVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLM 1303
Score = 381 bits (979), Expect = e-105
Identities = 234/625 (37%), Positives = 340/625 (53%), Gaps = 55/625 (8%)
Query: 642 KVSIWRLAKLNKP-EIPVILLGAIAAIVNGVVFPIFGFLFSAVISMF------------- 687
KVSI +L + E ++ +G + A++ G P+ L V F
Sbjct: 59 KVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGST 118
Query: 688 YKPPEQQRKESRF--------WSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTF 739
+ P Q ++ F WS + +G+ + + + + ++ R+R
Sbjct: 119 FLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLY--VAEQMNNRLRREFV 176
Query: 740 EKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVK 799
+ I+ QEISWFD ++ SG + +L + VK
Sbjct: 177 KSILRQEISWFD-----------------------------TNHSGTLATKLFDNLERVK 207
Query: 800 SLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADA 859
GD + + Q +S I G ++AFT +W L ++L +TP+ + G K + F+
Sbjct: 208 EGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRE 267
Query: 860 KVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSF 919
+ Y +A +V + +SSIRTV S ++ YS K GV GL GI FG
Sbjct: 268 TLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQ 327
Query: 920 LVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAA 979
+ + A FYIG V G F ++ F ++ M ++A+ A+ +A+
Sbjct: 328 ASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAAS 387
Query: 980 SIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTI 1039
I+E++D KP IDSSS AG + GDI +++V+F YP+RPD+ I + ++L + + +T+
Sbjct: 388 GIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTV 447
Query: 1040 ALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNES 1099
ALVG SG GKST+ISLL R+YD G+I +DGVD++ L +LR+ + +V QEP LFN +
Sbjct: 448 ALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCT 507
Query: 1100 IRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIA 1159
I NI GKE G T +E++AA ANA FI LP+GY+T VG+RGTQLSGGQKQRIAIA
Sbjct: 508 IEENISLGKE-GITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIA 566
Query: 1160 RTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIK 1219
R +++NPKILLLDEATSALDAESE IVQ+ALD+ + RTT+++AHRL+TIR AD I K
Sbjct: 567 RALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCK 626
Query: 1220 NGAVAEKGRHDELMRITDGVYASLV 1244
NG V E G H LM G+Y LV
Sbjct: 627 NGQVVEVGDHRALM-AQQGLYYDLV 650
Score = 329 bits (844), Expect = 3e-89
Identities = 206/591 (34%), Positives = 301/591 (50%), Gaps = 52/591 (8%)
Query: 21 IRDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNP 80
+ +N ++ F +L++ H + IG +A G P ++F + +N F + NP
Sbjct: 730 LEENNAQKTNLFEILYHARPH--ALSLFIGMSTATIGGFIYPTYSVFFTSFMNVF-AGNP 786
Query: 81 ADAIKQVSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFD 140
AD + Q +L+F+ LA GI SFL + E +R+ + +L Q I FFD
Sbjct: 787 ADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFD 846
Query: 141 TETN-TGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACV 199
+ N +G++ R++ D ++ A+ + + G +AF GW++A++++A +
Sbjct: 847 SPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAIL 906
Query: 200 PCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIK 259
P VA + + +A++G + + + +RTV + E E + K+
Sbjct: 907 PIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLD 966
Query: 260 IAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEK------------------ 301
I + +K+ + G G + + + A G L+I
Sbjct: 967 IPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITI 1026
Query: 302 -----GYNGGTVMTVIIALMTGGII----------------------KGDIELRDVSFRY 334
G+ A GGII G + ++V F Y
Sbjct: 1027 STSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRFAY 1086
Query: 335 PARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNL 394
P RP+++I G S V G T ALVG SG GKSTV++LLERFYD GE+ IDG +K L
Sbjct: 1087 PERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTL 1146
Query: 395 QLRWIREQIGLVSQEPILFTTSIRENIAYGKE--GATDEEITTAITLANAKKFIDKLPQG 452
R QI +VSQEP LF SI ENI YG + T ++ A LAN FI +LP+G
Sbjct: 1147 NPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEG 1206
Query: 453 LDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILK 512
+T G GTQLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE++VQEAL++
Sbjct: 1207 FETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREG 1266
Query: 513 RTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQ 563
RT +V+AHRL T+ NAD IAVV G I+E+GTH+ L M GAY +L + Q
Sbjct: 1267 RTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQL-MSEKGAYYKLTQKQ 1316
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 730 bits (1885), Expect = 0.0
Identities = 469/1306 (35%), Positives = 701/1306 (52%), Gaps = 128/1306 (9%)
Query: 28 QKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAF-------GSSNP 80
+K ++ LF ++ + L+++ + A A P + G + G+S+P
Sbjct: 27 RKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSP 86
Query: 81 ADAI-------------KQVSKVSLLFVYLAIGSG-----IASFLQVTCWMVTGER---- 118
A A+ K+ + +++ A G G +A FL +T + R
Sbjct: 87 AFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALN 146
Query: 119 QAARIRSLYLKTILQQDIAFFDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFC 178
Q RIR L+L+ +L+QDIA++DT + + +M+ D ++E +GEK+ L F
Sbjct: 147 QIDRIRKLFLEAMLRQDIAWYDTSSGSN-FASKMTEDLDKLKEGIGEKIVIVVFLIMTFV 205
Query: 179 GGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAI 238
G V AF+ GW+L +V+L+CVP + A + ++ + ++ + +Y++A NVV++ I
Sbjct: 206 IGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGI 265
Query: 239 RTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLV 298
RTV +F+G++K E++ + A T K+G+ SG G + I + LA+WYG L+
Sbjct: 266 RTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
Query: 299 IEKG------YNGGTVMTVIIALMTGG-------------------------IIK----- 322
+++ Y ++ V+ A++ G II
Sbjct: 326 LDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQV 385
Query: 323 --------------GDIELRDVSFRYPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKST 368
G I + FRYPARPDV+I G ++ V G T A VG SG GKST
Sbjct: 386 DPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKST 445
Query: 369 VISLLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFTTSIRENIAYGKEGA 428
+I L++RFYDP+AG V +DG +L+ L + W+R QIG+V QEP+LF T+I ENI YG+ A
Sbjct: 446 LIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSA 505
Query: 429 TDEEITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLD 488
T +I A AN FI +LP+G DT G+ G Q+SGGQKQRIAIARA+++ P++LLLD
Sbjct: 506 TQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLD 565
Query: 489 EATSALDAESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGL 548
EATSALD SE+ VQ ALE TT+VVAHRL+TI NAD I ++ G + E+GTH L
Sbjct: 566 EATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEEL 625
Query: 549 TMDPDGAYSQLIRLQEGDNEAEGSRKSEADK-LGDNLNIDSHMAGSSTQRTSFVRSISQT 607
M+ G Y +L+ + + E + A + L + N+ +
Sbjct: 626 -MERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQ 684
Query: 608 SSVSHRHSQSLRGLSGEIVESDIEQGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAI 667
+S S R S R + S + + D + KVS +L KLN PE I++G IA++
Sbjct: 685 TSGSSRDS-GFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASV 743
Query: 668 VNGVVFPIFGFLFSAVISMFYKPPEQ-QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIA 726
++G FP++G F + + R E S++FVG+GL+ + LQ + F A
Sbjct: 744 MHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTA 803
Query: 727 GGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGA 786
G K+ R+R F I+ Q+I++FDD ERN GA
Sbjct: 804 GVKMTTRLRKRAFGTIIGQDIAYFDD------------------------ERNS---VGA 836
Query: 787 VGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGI 846
+ +RL+ D S V+ G + ++Q ++T++ G+V+ F +W + LV P++ +
Sbjct: 837 LCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVY 896
Query: 847 VQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSK---KCLGPAKQ 903
++ +F+ + AK EEASQVA +A+++IRTV C E +V+D Y + + ++
Sbjct: 897 LEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDVACRR 956
Query: 904 GVRL-GLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVS 962
VR GLV +G FL Y G +LV + + ++ +V AL + +
Sbjct: 957 KVRFRGLVFALGQAAPFLAY----GISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLG 1012
Query: 963 QTTTLAPDTNKAKDSAA---SIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPT 1019
Q AP+ N A SA +F+ ++P+ S T E GDI ++V F YPT
Sbjct: 1013 QALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYN--TVEKSEGDIVYENVGFEYPT 1070
Query: 1020 RPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRL 1079
R I + L+L+I + T+ALVG SGSGKST + LL R+YDP SG + L GV F L
Sbjct: 1071 RKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPL 1130
Query: 1080 SWLRQQMGLVGQEPILFNESIRANIGYGK--EGGATEDEIIAAANAANAHSFISNLPDGY 1137
LR ++GLV QEP+LF+ +I NI YG + EII AA +N H+FIS LP GY
Sbjct: 1131 DTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGY 1190
Query: 1138 DTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNR 1197
DT +G + +QLSGGQKQRIAIAR +++NPKIL+LDEATSALD ESE++VQ+ALD R
Sbjct: 1191 DTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGR 1249
Query: 1198 TTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASL 1243
T + +AHRLTT+R AD I V+K G V E G HDELM + + +YA+L
Sbjct: 1250 TCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL-NKIYANL 1294
Score = 347 bits (891), Expect = 9e-95
Identities = 198/522 (37%), Positives = 287/522 (54%), Gaps = 37/522 (7%)
Query: 731 IERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGAR 790
I+RIR L E ++ Q+I+W+D S S + ++
Sbjct: 148 IDRIRKLFLEAMLRQDIAWYDTSSGSNFA-----------------------------SK 178
Query: 791 LSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMK 850
++ D +K +G+ + ++V I T + G+V AF W L +VL P I+ V +
Sbjct: 179 MTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVAR 238
Query: 851 FLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLV 910
+ Y +A+ V + S IRTV +F + K + + K + G + GL
Sbjct: 239 LQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLY 298
Query: 911 SGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFR------VFFALTMTAIAVSQT 964
SG+G S+L++Y A + G L+ + V+ V FA+ M A +
Sbjct: 299 SGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFA 358
Query: 965 TTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQ 1024
+ A + ++F IID +D G E G I + + F YP RPD++
Sbjct: 359 SPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVE 418
Query: 1025 IFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQ 1084
I K L++ + +T+A VG SG GKST+I L++RFYDP +G + LDG DL+T + WLR
Sbjct: 419 ILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRS 478
Query: 1085 QMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGER 1144
Q+G+VGQEP+LF +I NI YG+ AT+ +I AA AAN H FI+ LP GYDT VGE+
Sbjct: 479 QIGVVGQEPVLFATTIGENIRYGRP-SATQADIEKAARAANCHDFITRLPKGYDTQVGEK 537
Query: 1145 GTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAH 1204
G Q+SGGQKQRIAIAR +++ P++LLLDEATSALD SE+ VQ AL+ S TT+VVAH
Sbjct: 538 GAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAH 597
Query: 1205 RLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLVAL 1246
RL+TI AD I +K+G VAE+G H+ELM G+Y LV++
Sbjct: 598 RLSTITNADKIVFLKDGVVAEQGTHEELME-RRGLYCELVSI 638
Score = 328 bits (840), Expect = 7e-89
Identities = 203/592 (34%), Positives = 309/592 (51%), Gaps = 52/592 (8%)
Query: 22 RDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNPA 81
+D + KV F L + + +++G I++V +G PL LF G+ +
Sbjct: 711 KDKEVVSKVSFTQLMKL-NSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDD 769
Query: 82 DAIKQVSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDT 141
+V K+S++FV + + +G+ + LQ + G + R+R TI+ QDIA+FD
Sbjct: 770 VVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDD 829
Query: 142 ETNT-GEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVP 200
E N+ G + R++ D +Q A G +VG Q + G V+ F+ W+ ++ L +P
Sbjct: 830 ERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLP 889
Query: 201 CVAVAGAFMSIVMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKI 260
V ++ + K + + + + EA V + + IRTV E++ +++Y +I
Sbjct: 890 LVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDR 949
Query: 261 AYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTGGI 320
++ G + F YG++M+YG LV E+ N ++ V AL+ G
Sbjct: 950 VDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSW 1009
Query: 321 I---------------------------------------------KGDIELRDVSFRYP 335
+ +GDI +V F YP
Sbjct: 1010 MLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYP 1069
Query: 336 ARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQ 395
R I G +L + TT ALVG SGSGKST + LL R+YDP +G V + GV
Sbjct: 1070 TRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
Query: 396 LRWIREQIGLVSQEPILFTTSIRENIAYG---KEGATDEEITTAITLANAKKFIDKLPQG 452
L +R ++GLVSQEP+LF +I ENIAYG ++ + +EI A +N FI LPQG
Sbjct: 1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQG 1189
Query: 453 LDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILK 512
DT G+ +QLSGGQKQRIAIARA+++NPKIL+LDEATSALD ESE++VQ+AL++
Sbjct: 1190 YDTRLGKT-SQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSG 1248
Query: 513 RTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQE 564
RT + +AHRLTT+RNAD+I V+++G +VE GTH L M + Y+ L +Q+
Sbjct: 1249 RTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDEL-MALNKIYANLYLMQQ 1299
>PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1
Length = 1362
Score = 725 bits (1872), Expect = 0.0
Identities = 460/1316 (34%), Positives = 709/1316 (52%), Gaps = 127/1316 (9%)
Query: 24 NKTKQKVPFY-MLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAF---GSSN 79
N T K+ Y + ++AD D+ L + GTI+ + GL PLM+L G + AF S
Sbjct: 71 NDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTDLASGK 130
Query: 80 PADAIKQ-VSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAF 138
A + + V L F+Y+AIG S++ +++ GER A RIR YL IL Q+I +
Sbjct: 131 GASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDYLHAILSQNIGY 190
Query: 139 FDTETNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLAC 198
FD GE+ R++ DT IQ+ +GEKVG F + F GFV+AFI+ W+ ++L +
Sbjct: 191 FD-RLGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTLILSSM 249
Query: 199 VPCVAVAGAFMSIVMAKMSSRGQIAY-AEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSK 257
P + G + + +++GQIA AE+ V++ IR +F + + YN
Sbjct: 250 FPAIC-GGIGLGVPFITKNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKY 308
Query: 258 IKIAYTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLV----IEKGYNGGTVMTVII 313
+ A + + I G +G + F+A+ YGLA W G +L+ ++ G V+I
Sbjct: 309 LITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAGDLDVSKLIGCFFAVLI 368
Query: 314 ALM-------------------------------------TGGI---IKGDIELRDVSFR 333
A TG + IKG+IEL+++ F
Sbjct: 369 ASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGEIELKNIRFV 428
Query: 334 YPARPDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKN 393
YP RP+V + D FSL PSG TALVG SGSGKST+I L+ERFYDP G+V +DG +L+
Sbjct: 429 YPTRPEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRT 488
Query: 394 LQLRWIREQIGLVSQEPILFTTSIRENIAYGK----EGATDEE-----ITTAITLANAKK 444
L + +R QI LV QEP+LF T++ ENI YG +G +E + A LANA
Sbjct: 489 LNVASLRNQISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYDAAKLANAYD 548
Query: 445 FIDKLPQGLDTMAGQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQE 504
FI LP+ T GQ G +SGGQKQRIAIARA++ +PKILLLDEATSALD++SE +VQ+
Sbjct: 549 FIMTLPEQFSTNVGQRGFLMSGGQKQRIAIARAVISDPKILLLDEATSALDSKSEVLVQK 608
Query: 505 ALEKIILKRTTVVVAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQ- 563
AL+ RTT+V+AHRL+TIRNAD I VV GKIVE+G+H+ L +D +GAY++L+ Q
Sbjct: 609 ALDNASRSRTTIVIAHRLSTIRNADNIVVVNAGKIVEQGSHNEL-LDLNGAYARLVEAQK 667
Query: 564 ----EGDNEAEGSRKSEA------------DKLGDNLNIDSHMAGSSTQRTSFVRSISQT 607
E D E +A D+ D ++++ M +T + +++
Sbjct: 668 LSGGEKDQEMVEEELEDAPREIPITSFGDDDEDNDMASLEAPMMSHNTDTDTLNNKLNEK 727
Query: 608 SSVSHRHSQSLRGLSGEIVES----DIEQGQLDNKKKPK-----------VSIWRLAKLN 652
+V ++L+ ++ EIV + D+ + + KK K ++W +
Sbjct: 728 DNVVFE-DKTLQHVASEIVPNLPPADVGELNEEPKKSKKSKKNNHEINSLTALWFIHSFV 786
Query: 653 KPEIPVI--LLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQQ-RKESRFWSLLFVGLG 709
+ I +I L+G +A+++ G +P+ +F+ +++F + +++ ++ L
Sbjct: 787 RTMIEIICLLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHKVNVFAVYWLILA 846
Query: 710 LVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK 769
+V + NF A +++RIR F ++ Q++ +FD
Sbjct: 847 IVQFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFD------------------ 888
Query: 770 **KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWI 829
R+E++ GA+ LS +++ L G T+ Q ++ +I+ +++ W
Sbjct: 889 --------RSENTV-GAITTSLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWK 939
Query: 830 LAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKV 889
L + L +P+I+ G +++ L Y+E++ A ++ S+IRTVAS E V
Sbjct: 940 LGLVTLSTSPVIITAGYYRVRALDQVQEKLSAAYKESAAFACESTSAIRTVASLNREENV 999
Query: 890 MDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVLVQHGKATFTEVFR 949
Y + P ++ L SG+ F + V + NA F+ GS L++ G+ + +
Sbjct: 1000 FAEYCDSLIKPGRESAIASLKSGLFFSAAQGVTFLINALTFWYGSTLMRKGEYNIVQFYT 1059
Query: 950 VFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAGVTRETVVGD-I 1008
F A+ Q + D KAK +A I + +SKP ID+ S G E++ I
Sbjct: 1060 CFIAIVFGIQQAGQFFGYSADVTKAKAAAGEIKYLSESKPKIDTWSTEGKKVESLQSAAI 1119
Query: 1009 ELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRIL 1068
E + V F+YPTR I++ + L+L++ + +A VG SG GKST I L+ERFYD ++G +L
Sbjct: 1120 EFRQVEFSYPTRRHIKVLRGLNLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVL 1179
Query: 1069 LDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHS 1128
+DGV+++ + ++ R+Q+ LV QEP L+ ++R NI G +E+E+I A AN H
Sbjct: 1180 VDGVNVRDYNINDYRKQIALVSQEPTLYQGTVRENIVLGASKDVSEEEMIEACKKANIHE 1239
Query: 1129 FISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQE 1188
FI LP+GY+T G++G+ LSGGQKQRIAIAR +++NPKILLLDEATSALD+ SE++VQE
Sbjct: 1240 FILGLPNGYNTLCGQKGSSLSGGQKQRIAIARALIRNPKILLLDEATSALDSHSEKVVQE 1299
Query: 1189 ALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLV 1244
AL+ S RTTV +AHRL++I+ AD I V G +AE G H EL++ G Y LV
Sbjct: 1300 ALNAASQGRTTVAIAHRLSSIQDADCIFVFDGGVIAEAGTHAELVK-QRGRYYELV 1354
Score = 313 bits (801), Expect = 2e-84
Identities = 202/576 (35%), Positives = 300/576 (52%), Gaps = 51/576 (8%)
Query: 42 LDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNPADAIKQVSKVSLLFVYLAIGS 101
+++ ++IG ++++ G A P+ +N F + D + +V+ ++ ++ LAI
Sbjct: 790 IEIICLLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHKVNVFAVYWLILAIVQ 849
Query: 102 GIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETNT-GEVIGRMSGDTILIQ 160
A + E RIR +T+L+QD+ FFD NT G + +S ++
Sbjct: 850 FFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITTSLSTKIQSLE 909
Query: 161 EAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMAKMSSRG 220
G +G FFQ+ +N +++ GW+L +V L+ P + AG + + ++ +
Sbjct: 910 GLSGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQVQEKL 969
Query: 221 QIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKY-NSKIKIAYTTMVKQGIVSGFGIGML 279
AY E+ ++ AIRTVAS E+ +Y +S IK + + + SG
Sbjct: 970 SAAYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIAS-LKSGLFFSAA 1028
Query: 280 TFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTG--------------------- 318
+ F L WYGS L+ + YN T IA++ G
Sbjct: 1029 QGVTFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAA 1088
Query: 319 GIIK------------------------GDIELRDVSFRYPARPDVQIFDGFSLFVPSGT 354
G IK IE R V F YP R +++ G +L V G
Sbjct: 1089 GEIKYLSESKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQ 1148
Query: 355 TTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPILFT 414
A VG SG GKST I L+ERFYD D G VL+DGVN+++ + R+QI LVSQEP L+
Sbjct: 1149 FVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALVSQEPTLYQ 1208
Query: 415 TSIRENIAYG-KEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQRIA 473
++RENI G + ++EE+ A AN +FI LP G +T+ GQ G+ LSGGQKQRIA
Sbjct: 1209 GTVRENIVLGASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLSGGQKQRIA 1268
Query: 474 IARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVAHRLTTIRNADIIAV 533
IARA+++NPKILLLDEATSALD+ SE++VQEAL RTTV +AHRL++I++AD I V
Sbjct: 1269 IARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSSIQDADCIFV 1328
Query: 534 VQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEA 569
G I E GTH+ L + G Y +L+ +++G N+A
Sbjct: 1329 FDGGVIAEAGTHAEL-VKQRGRYYELV-VEQGLNKA 1362
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 686 bits (1771), Expect = 0.0
Identities = 446/1337 (33%), Positives = 693/1337 (51%), Gaps = 139/1337 (10%)
Query: 3 ENPNVHDNSSSSPTQQHG--IRDNKTKQKVPFYMLFNFADHLDVTLMIIGTISAVANGLA 60
E V +SS +Q+ + + + F LF F+ + ++ + G I L
Sbjct: 2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALT 61
Query: 61 SPLMTLFLGNVINA-------FGSSNPADAI------KQVSKVS---------------- 91
P + + + FG+S+ A+ K ++ S
Sbjct: 62 LPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYG 121
Query: 92 LLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETNTGEVIGR 151
+L ++ I+ V + + RQ R+R ++++QDI + D +
Sbjct: 122 ILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQN-FTQS 180
Query: 152 MSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSI 211
M D I++ + EKVG F L F ++F GW+L + + + +P V + +++
Sbjct: 181 MVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAK 240
Query: 212 VMAKMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIV 271
K+++R Q +YA AGN+ ++ + +IRTV SF GEK +++Y + + A +G
Sbjct: 241 FQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAF 300
Query: 272 SGFGIGMLTFIAFCTYGLAMWYGSKLVIE------KGYNGGTVMTVIIALMTGGI----- 320
SG +L + + + A WYG L+I+ K Y +M ++ G
Sbjct: 301 SGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIART 360
Query: 321 ----------------------------------------IKGDIELRDVSFRYPARPDV 340
++GD+E +DV FRYP+RP+V
Sbjct: 361 APFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEV 420
Query: 341 QIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIR 400
+ G ++ + +G T ALVG SG GKST + LL+RFYDP G VL+D ++++ ++W+R
Sbjct: 421 IVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLR 480
Query: 401 EQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQN 460
I +V QEP+LF +I +NI+YGK GAT +EI A T A A +FI LP+ +M G+
Sbjct: 481 SNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGER 540
Query: 461 GTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVVVAH 520
G+QLSGGQKQRIAIARA+++NPKILLLDEATSALD +SE+ VQ+AL+ RTT+VV+H
Sbjct: 541 GSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSH 600
Query: 521 RLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSRKSEADKL 580
RL+ IR AD I + GK++E G+H L M +GAY ++R GD + E D +
Sbjct: 601 RLSAIRGADKIVFIHDGKVLEEGSHDDL-MALEGAYYNMVR--AGDINMPDEVEKE-DSI 656
Query: 581 GDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQGQLDNKKK 640
D + S + + Q +SV Q + +++ Q +K
Sbjct: 657 EDTKQKSLALFEKSFETSPLNFEKGQKNSV-----QFEEPIIKALIKDTNAQSAEAPPEK 711
Query: 641 PKV--SIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSA-VISMFYKPPEQQRKE 697
P + R+ +L K E ++LG I+A+ G ++P F +F ++ K PE +
Sbjct: 712 PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR 771
Query: 698 SRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSR 757
+ S +GL +T ++ LQ + F AG L R+R++TF +V+QE+ WFDD
Sbjct: 772 TAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDD----- 826
Query: 758 YVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTVI 817
E++ GA+ ARLS +A ++ +G ++ ++Q +S I
Sbjct: 827 ----------------------ENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFI 864
Query: 818 AGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSI 877
+ + +A NW LA + L P+I+ I++ K + K + EEA ++A +++++I
Sbjct: 865 SSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNI 924
Query: 878 RTVASFCAESKVMDMYSKKCLGP---AKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGS 934
RTVA E+ V+ Y+++ +Q +R V S Y A G
Sbjct: 925 RTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY---AVALCYGG 981
Query: 935 VLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSS 994
VLV G+ F ++ +V L ++ ++Q+ P + A + +F+I+D KP I S
Sbjct: 982 VLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSP 1041
Query: 995 SNAGVTRETVVGDIEL------QHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSG 1048
G + T+ + L + + F YPTRPD +I L L + +T+ALVG SG G
Sbjct: 1042 --MGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCG 1099
Query: 1049 KSTVISLLERFYDPNSGRILLDGVDLK-TFRLSWLRQQMGLVGQEPILFNESIRANIGYG 1107
KST + LL+R+YDP+ G I +D D++ L +R ++G+V QEP LF SI NI YG
Sbjct: 1100 KSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYG 1159
Query: 1108 -KEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNP 1166
+ EIIAAA +ANAHSFI +LP+GYDT +G RGTQLSGGQKQRIAIAR +++NP
Sbjct: 1160 DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNP 1219
Query: 1167 KILLLDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEK 1226
KILLLDEATSALD +SE++VQ+ALD RT +V+AHRL+T++ AD I VI+NG V E+
Sbjct: 1220 KILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQ 1279
Query: 1227 GRHDELMRITDGVYASL 1243
G H +L+ G+YA L
Sbjct: 1280 GNHMQLIS-QGGIYAKL 1295
Score = 328 bits (840), Expect = 7e-89
Identities = 201/529 (37%), Positives = 293/529 (54%), Gaps = 38/529 (7%)
Query: 723 FGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESS 782
F + + + R+R F ++ Q+I W D S + V + E R+
Sbjct: 142 FNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMV--------DDVEKIRDG-- 191
Query: 783 CSGAVGARLSIDASTVKSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMIL 842
+ VG + L+V I TV I+F+ W L V P+++
Sbjct: 192 ---------------ISEKVGHFVYLVVGFIITV----AISFSYGWKLTLAVSSYIPLVI 232
Query: 843 MQGIVQMKFLKGFSADAKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAK 902
+ KF +A + Y A +A + +SSIRTV SF E + Y + K
Sbjct: 233 LLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARK 292
Query: 903 QGVRLGLVSGIGFGC--SFLVLYCTNAFIFYIGSVL----VQHGKATFTEVFRVFFALTM 956
G SG+ S L L C AF + + ++ V++ + T + FF + +
Sbjct: 293 ASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIV 352
Query: 957 TAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSNAG-VTRETVVGDIELQHVNF 1015
A +++T A+ A ++F++ID ID S G + + GD+E Q V F
Sbjct: 353 GADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFF 412
Query: 1016 NYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLK 1075
YP+RP++ + + L++ I + +T+ALVG SG GKST + LL+RFYDP G +LLD +D++
Sbjct: 413 RYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIR 472
Query: 1076 TFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPD 1135
+ + WLR + +VGQEP+LF +I NI YGK GAT+ EI AAA A AH FI+NLP+
Sbjct: 473 KYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKP-GATQKEIEAAATQAGAHEFITNLPE 531
Query: 1136 GYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATSALDAESERIVQEALDRVSV 1195
Y + +GERG+QLSGGQKQRIAIAR +++NPKILLLDEATSALD +SE+ VQ+ALD S
Sbjct: 532 SYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASK 591
Query: 1196 NRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMRITDGVYASLV 1244
RTT+VV+HRL+ IRGAD I I +G V E+G HD+LM + +G Y ++V
Sbjct: 592 GRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMAL-EGAYYNMV 639
>MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprotein C)
Length = 1268
Score = 655 bits (1689), Expect = 0.0
Identities = 423/1279 (33%), Positives = 660/1279 (51%), Gaps = 102/1279 (7%)
Query: 32 FYMLFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAF---------GSSNPAD 82
F+ +F AD+ D L G I + NG P +L + NA G+ N
Sbjct: 31 FFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPW 90
Query: 83 AIKQVSKVSLLFVYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTE 142
++ L + YL + + S+ +C ER+ IR YLK++L+QD +FD E
Sbjct: 91 FSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFD-E 149
Query: 143 TNTGEVIGRMSGDTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCV 202
T G + +MS I++ +G+KVG + F G + F W+L +V++ VP +
Sbjct: 150 TTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVP-L 208
Query: 203 AVAGAFMSIVMAKMSSRGQI-AYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIA 261
+ ++S +++ ++ AY+ AG + ++ + IRTV +F + I +Y ++ A
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEA 268
Query: 262 YTTMVKQGIVSGFGIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTGGI- 320
+++ I+ + F +A WYG+ L + G V V A++ G
Sbjct: 269 RRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRR 328
Query: 321 -------------------------------------------IKGDIELRDVSFRYPAR 337
I+G + + F YP R
Sbjct: 329 LGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTR 388
Query: 338 PDVQIFDGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLR 397
P+++I G S V G T ALVG SG GKST I LL RFY+ AG + +DG+ ++ +R
Sbjct: 389 PELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIR 448
Query: 398 WIREQIGLVSQEPILFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMA 457
W+R IG+V QEPI+F ++ ENI G TD++I A +ANA +FI KL DT+
Sbjct: 449 WLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVI 508
Query: 458 GQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILKRTTVV 517
G QLSGGQKQR+AIARAI++ P+ILLLDEATSALD ESER+VQ AL+K RTT+
Sbjct: 509 GAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLC 568
Query: 518 VAHRLTTIRNADIIAVVQQGKIVERGTHSGLTMDPDGAYSQLIRLQEGDNEAEGSR--KS 575
+AHRL+TIRNA I V QG I ERGTH L DG Y+ +++ QE + E +
Sbjct: 569 IAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDE 628
Query: 576 EADKLGDNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQG-- 633
E +K + + DS +S + +S+++ S+ R QS+ + ++ E +IE
Sbjct: 629 EDEKTHRSFHRDS---VTSDEERELQQSLARDST---RLRQSMISTTTQVPEWEIENARE 682
Query: 634 QLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMFYKPPEQ 693
++ + + S++ + K PE+ I++ + ++ G +P F ++ + + +
Sbjct: 683 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 742
Query: 694 QRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDP 753
++ SL F+ L + + G AG + R+R F I+ Q+ S+FDD
Sbjct: 743 VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 802
Query: 754 SHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNI 813
H+ G++ +RL+ DA V++ + +A ++ I
Sbjct: 803 RHN---------------------------VGSLTSRLATDAPNVQAAIDQRLAEVLTGI 835
Query: 814 STVIAGLVIAFTANWILAFIVL--VLTPMILMQGIVQ-MKFLKGFSADAKVMYEEASQVA 870
++ G+ +AF W +A I L L +++ + Q +KF D+ + EAS++
Sbjct: 836 VSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSSVAQYLKFRGQRDMDSAI---EASRLV 892
Query: 871 NDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIF 930
+++S+ +TV + + + D ++ P ++ + GL + F + + A +
Sbjct: 893 TESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAY 952
Query: 931 YIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPD 990
G L+ + +T VF+V AL M +++V + P+ +A+ SA +F +I K
Sbjct: 953 MFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSV 1012
Query: 991 IDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKS 1050
ID+ G T T+ G+I ++ V F YP R + ++S +T+ALVG SG GKS
Sbjct: 1013 IDNRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKS 1071
Query: 1051 TVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEG 1110
T I L+ER+YD G + +D D++ + LR + LVGQEP LFN +IR NI YG E
Sbjct: 1072 TTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE- 1130
Query: 1111 GATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILL 1170
T+D++ AA AN H+F+ LPDGYDTSVG G +LSGGQKQR+AIAR ++++PKILL
Sbjct: 1131 NITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILL 1190
Query: 1171 LDEATSALDAESERIVQEALDRVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHD 1230
LDEATSALD ESE+IVQEALD+ + RT VV+AHRL+TI+ AD I V +NG E+G H
Sbjct: 1191 LDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQ 1250
Query: 1231 ELMRITDGVYASLVALHSS 1249
L+ G+Y LV SS
Sbjct: 1251 TLL-ARRGLYYRLVEKQSS 1268
>MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1280
Score = 619 bits (1595), Expect = e-176
Identities = 414/1276 (32%), Positives = 650/1276 (50%), Gaps = 117/1276 (9%)
Query: 35 LFNFADHLDVTLMIIGTISAVANGLASPLMTLFLGNVINAFGSSNPADAIKQVSKVSLLF 94
+F +AD D LMI GT AVA G P+ + G + S A ++ +K SL+
Sbjct: 60 IFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDL-MSGVGSAEEKAAKTSLIM 118
Query: 95 VYLAIGSGIASFLQVTCWMVTGERQAARIRSLYLKTILQQDIAFFDTETNTGEVIGRMSG 154
VY+ I IA V CW V RQ ARIR L+ + +L+QDI + D E + G + RM+G
Sbjct: 119 VYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHD-EHSPGALTARMTG 177
Query: 155 DTILIQEAMGEKVGKFFQLASNFCGGFVMAFIKGWRLAIVLLACVPCVAVAGAFMSIVMA 214
DT +IQ + +K+ + S G++ F+ W L ++++ +P + V A + +++
Sbjct: 178 DTRVIQNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVS 237
Query: 215 KMSSRGQIAYAEAGNVVDQTVGAIRTVASFTGEKKAIEKYNSKIKIAYTTMVKQGIVSGF 274
K++ + +A+AG++ + + IRTV +F E +E++ + A +++ + S
Sbjct: 238 KITESSRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNL 297
Query: 275 GIGMLTFIAFCTYGLAMWYGSKLVIEKGYNGGTVMTVIIALMTGGI-------------- 320
++ + + +Y +A ++GS LV + +++ +A++ G
Sbjct: 298 SAAVIMALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTE 357
Query: 321 -----------------------------IKGDIELRDVSFRYPARPDVQIFDGFSLFVP 351
K IE R+V F YP RP + +F SL +
Sbjct: 358 SRAAAYEIFKAIDRVPPVDIDAGGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIK 417
Query: 352 SGTTTALVGQSGSGKSTVISLLERFYDPDAGEVLIDGVNLKNLQLRWIREQIGLVSQEPI 411
G A G SG GKS+VI L++RFYDP G VL+DGV ++ L LR R+QIG+VSQEP
Sbjct: 418 CGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPN 477
Query: 412 LFTTSIRENIAYGKEGATDEEITTAITLANAKKFIDKLPQGLDTMAGQNGTQLSGGQKQR 471
LF ++ EN+ GK ATDEE+ A AN I LP DT G G+ LSGGQKQR
Sbjct: 478 LFAGTMMENVRMGKPNATDEEVVEACRQANIHDTIMALPDRYDTPVGPVGSLLSGGQKQR 537
Query: 472 IAIARAILKNPKILLLDEATSALDAESERIVQEALEKIILK--RTTVVVAHRLTTIRNAD 529
IAIARA++K P ILLLDEATSALD +SE VQ AL+++I + T VV+AHRL TIR+ D
Sbjct: 538 IAIARALVKRPPILLLDEATSALDRKSEMEVQAALDQLIQRGGTTVVVIAHRLATIRDMD 597
Query: 530 IIAVVQQ-----GKIVERGTHSGLTMDPDGAYSQLIRLQ---EGDNEAEGSRKSEADKLG 581
I V+ +I E GT L ++ DG ++ + ++Q GD ++ G+ +A K
Sbjct: 598 RIYYVKHDGAEGSRITESGTFDEL-LELDGEFAAVAKMQGVLAGDAKS-GASVRDAKKAS 655
Query: 582 DNLNIDSHMAGSSTQRTSFVRSISQTSSVSHRHSQSLRGLSGEIVESDIEQGQLDNKKKP 641
+L + A + R+ Q + E+ + ++ K
Sbjct: 656 GHLGVILDEADLAQLDEDVPRTARQNVPID------------ELAKWEV--------KHA 695
Query: 642 KVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGFLFSAVISMF-----YKPPEQQRK 696
KV RL ++NK + + LG ++++V G P + ++ + K E R
Sbjct: 696 KVGFLRLMRMNKDKAWAVALGILSSVVIGSARPASSIVMGHMLRVLGEYSATKDVEALRS 755
Query: 697 ESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLTFEKIVHQEISWFDDPSHS 756
+ ++ LF+ + L F+G AG L +IR L F +I+ Q+I++FD P
Sbjct: 756 GTNLYAPLFIVFAVANFSGWILHG-FYGYAGEHLTTKIRVLLFRQIMRQDINFFDIPGRD 814
Query: 757 RYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTVKSLVGDTMALIVQNISTV 816
+G + LS D V L G ++ L VQ + +
Sbjct: 815 ---------------------------AGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCII 847
Query: 817 IAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSADAKVMYEEASQVANDAVSS 876
+GLV+ F W LA + L P+++ + + + G++ + ++ + +A+S+
Sbjct: 848 ASGLVVGFIYQWKLALVALACMPLMIGCSLTRRLMINGYTKSREGDTDDT--IVTEALSN 905
Query: 877 IRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCSFLVLYCTNAFIFYIGSVL 936
+RTV S + ++ + A + VR G+++G +G + + Y A F+ GS L
Sbjct: 906 VRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYGSKL 965
Query: 937 VQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSAASIFEIIDSKPDIDSSSN 996
+ G+A F +V ++ A + A A+ SA +F +ID PD+D
Sbjct: 966 IDKGEAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVPDVD-IEQ 1024
Query: 997 AGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKTIALVGESGSGKSTVISLL 1056
AG DIE ++V F Y RP + +++ A + L+G++G GKSTVI +L
Sbjct: 1025 AGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTVIQML 1084
Query: 1057 ERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNESIRANIGYGKEGGATEDE 1116
RFY+ SG I ++G DL + ++ R+ + +V QEP LF+ ++R NI Y +E GAT++E
Sbjct: 1085 ARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYARE-GATDEE 1143
Query: 1117 IIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAIARTMLKNPKILLLDEATS 1176
+ AA A+ H I DGYDT VG +G LSGGQKQRIAIAR +L+ P++LLLDEATS
Sbjct: 1144 VEEAARLAHIHHEIIKWTDGYDTEVGYKGRALSGGQKQRIAIARGLLRRPRLLLLDEATS 1203
Query: 1177 ALDAESERIVQEALD--RVSVNRTTVVVAHRLTTIRGADTIAVIKNGAVAEKGRHDELMR 1234
ALD+ +E VQE ++ + TTV +AHRLTTIR D I ++ +G + E+G H+ELM
Sbjct: 1204 ALDSVTEAKVQEGIEAFQAKYKVTTVSIAHRLTTIRHCDQIILLDSGCIIEQGSHEELMA 1263
Query: 1235 ITDGVYASLVALHSSA 1250
+ G Y + L+ SA
Sbjct: 1264 L-GGEYKTRYDLYMSA 1278
Score = 311 bits (797), Expect = 7e-84
Identities = 197/635 (31%), Positives = 324/635 (51%), Gaps = 42/635 (6%)
Query: 620 GLSGEIVESDIE-QGQLDNKKKPKVSIWRLAKLNKPEIPVILLGAIAAIVNGVVFPIFGF 678
G G + ++ E +G + + + I+R A + + +++ G A+ G P+F F
Sbjct: 34 GSQGPLFSAEEEVKGTVVRETVGPIEIFRYA--DATDRVLMIAGTAFAVACGAGMPVFSF 91
Query: 679 LFSAVISMFYKPPEQQRKESRFWSLLFVGLGLVTLVILPLQNFFFGIAGGKLIERIRSLT 738
+F + +++ SL+ V +G+ L+ + +A + + RIR L
Sbjct: 92 IFGRIAMDLMSGVGSAEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLF 151
Query: 739 FEKIVHQEISWFDDPSHSRYVIQNVCYFMTK**KNYETERNESSCSGAVGARLSIDASTV 798
F ++ Q+I W D+ S GA+ AR++ D +
Sbjct: 152 FRAVLRQDIGWHDEHS-----------------------------PGALTARMTGDTRVI 182
Query: 799 KSLVGDTMALIVQNISTVIAGLVIAFTANWILAFIVLVLTPMILMQGIVQMKFLKGFSAD 858
++ + D ++ + N S + G + F +W L +++ + P I++ + + +
Sbjct: 183 QNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITES 242
Query: 859 AKVMYEEASQVANDAVSSIRTVASFCAESKVMDMYSKKCLGPAKQGVRLGLVSGIGFGCS 918
++ + +A +A + + +IRTV +F E ++ ++K L +G+R L S +
Sbjct: 243 SRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVI 302
Query: 919 FLVLYCTNAFIFYIGSVLVQHGKATFTEVFRVFFALTMTAIAVSQTTTLAPDTNKAKDSA 978
++Y + F+ GS LV+ G+ ++ F A+ M + + +++ +A
Sbjct: 303 MALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAA 362
Query: 979 ASIFEIIDSKPDIDSSSNAGVTRETVVGDIELQHVNFNYPTRPDIQIFKDLSLSIPSAKT 1038
IF+ ID P +D + GV IE ++V F YPTRP + +F+DLSL I +
Sbjct: 363 YEIFKAIDRVPPVDIDA-GGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQK 421
Query: 1039 IALVGESGSGKSTVISLLERFYDPNSGRILLDGVDLKTFRLSWLRQQMGLVGQEPILFNE 1098
+A G SG GKS+VI L++RFYDP G +L+DGV ++ L R Q+G+V QEP LF
Sbjct: 422 VAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFAG 481
Query: 1099 SIRANIGYGKEGGATEDEIIAAANAANAHSFISNLPDGYDTSVGERGTQLSGGQKQRIAI 1158
++ N+ GK AT++E++ A AN H I LPD YDT VG G+ LSGGQKQRIAI
Sbjct: 482 TMMENVRMGKP-NATDEEVVEACRQANIHDTIMALPDRYDTPVGPVGSLLSGGQKQRIAI 540
Query: 1159 ARTMLKNPKILLLDEATSALDAESERIVQEALDRV--SVNRTTVVVAHRLTTIRGADTIA 1216
AR ++K P ILLLDEATSALD +SE VQ ALD++ T VV+AHRL TIR D I
Sbjct: 541 ARALVKRPPILLLDEATSALDRKSEMEVQAALDQLIQRGGTTVVVIAHRLATIRDMDRIY 600
Query: 1217 VIKN-----GAVAEKGRHDELMRITDGVYASLVAL 1246
+K+ + E G DEL+ + DG +A++ +
Sbjct: 601 YVKHDGAEGSRITESGTFDELLEL-DGEFAAVAKM 634
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.136 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 133,136,496
Number of Sequences: 164201
Number of extensions: 5509050
Number of successful extensions: 25133
Number of sequences better than 10.0: 1030
Number of HSP's better than 10.0 without gapping: 876
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 19487
Number of HSP's gapped (non-prelim): 3333
length of query: 1250
length of database: 59,974,054
effective HSP length: 122
effective length of query: 1128
effective length of database: 39,941,532
effective search space: 45054048096
effective search space used: 45054048096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Medicago: description of AC144478.12