BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144431.4 - phase: 0 /pseudo
(1510 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DPOA_ORYSA (O48653) DNA polymerase alpha catalytic subunit (EC 2... 1468 0.0
DPOA_XENLA (Q9DE46) DNA polymerase alpha catalytic subunit (EC 2... 692 0.0
DPOA_HUMAN (P09884) DNA polymerase alpha catalytic subunit (EC 2... 685 0.0
DPOA_RAT (O89042) DNA polymerase alpha catalytic subunit (EC 2.7... 672 0.0
DPOA_MOUSE (P33609) DNA polymerase alpha catalytic subunit (EC 2... 667 0.0
DPOA_OXYNO (Q94636) DNA polymerase alpha catalytic subunit (EC 2... 639 0.0
DPOA_OXYTR (Q27152) DNA polymerase alpha catalytic subunit (EC 2... 631 e-180
DPOA_SCHPO (P28040) DNA polymerase alpha catalytic subunit (EC 2... 585 e-166
DPOA_DROME (P26019) DNA polymerase alpha catalytic subunit (EC 2... 574 e-163
DPOA_LEIDO (O00874) DNA polymerase alpha catalytic subunit (EC 2... 523 e-147
DPOA_YEAST (P13382) DNA polymerase alpha catalytic subunit (EC 2... 522 e-147
DPOA_TRYBB (P27727) DNA polymerase alpha catalytic subunit (EC 2... 513 e-144
DPOL_THEGO (P56689) DNA polymerase (EC 2.7.7.7) (TO POL) 222 5e-57
DPOD_SOYBN (O48901) DNA polymerase delta catalytic subunit (EC 2... 210 2e-53
DPOD_ORYSA (Q9LRE6) DNA polymerase delta catalytic subunit (EC 2... 207 1e-52
DPOD_MESAU (P97283) DNA polymerase delta catalytic subunit (EC 2... 203 3e-51
DPOD_BOVIN (P28339) DNA polymerase delta catalytic subunit (EC 2... 202 6e-51
DPOD_MOUSE (P52431) DNA polymerase delta catalytic subunit (EC 2... 202 7e-51
DPOD_ARATH (Q9LVN7) DNA polymerase delta catalytic subunit (EC 2... 199 4e-50
DPOD_HUMAN (P28340) DNA polymerase delta catalytic subunit (EC 2... 196 4e-49
>DPOA_ORYSA (O48653) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1243
Score = 1468 bits (3801), Expect = 0.0
Identities = 746/1169 (63%), Positives = 915/1169 (77%), Gaps = 55/1169 (4%)
Query: 385 GTLYQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDT 444
G + SCCVVVKNMQRC+YAIPS + + + +LEK+ S SP+ R L + S
Sbjct: 86 GKRFHSCCVVVKNMQRCIYAIPSSSIFPRDTISRLEKNSTTSDSSPS-LRASLHELASGL 144
Query: 445 KNEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSF 504
K+EIA L D VS+F+M PVKR YAFERTD+P GE YV+KINY +KD+ALP DL+G+ F
Sbjct: 145 KSEIADKLSDFNVSNFAMTPVKRNYAFERTDLPNGEQYVLKINYPYKDSALPTDLRGQHF 204
Query: 505 CALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSP 564
ALLG NSALEL LIKRKIKGPSWL +S F C A+QRVSWCKFEV VDSPKDI
Sbjct: 205 HALLGTNNSALELLLIKRKIKGPSWLSISKFLACPATQRVSWCKFEVTVDSPKDISVLMT 264
Query: 565 SSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGML 624
S+ TL PPVVV A+NLKT INEK N++EIVSASV+ C+ VKID+PM + +W++ GML
Sbjct: 265 ST---TLEVPPVVVAAVNLKTIINEKHNVHEIVSASVICCHRVKIDSPMRSEDWQKRGML 321
Query: 625 THFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLV 684
+HFTV+RKL+G+IFP+G + E +DRN KAGSNVL +ESSERALLNRLM++L K+D DVLV
Sbjct: 322 SHFTVMRKLEGSIFPIGLSKESSDRNQKAGSNVLALESSERALLNRLMIELSKLDCDVLV 381
Query: 685 GHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVA 744
GHNISGFDLDVLLHR+Q C+VPS+MWSK+GRL RS MP+L + +G GA P IMSC+A
Sbjct: 382 GHNISGFDLDVLLHRAQTCKVPSNMWSKIGRLRRSVMPRLTKGNTLYGSGASPGIMSCIA 441
Query: 745 GRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAKSLMELIEYGE 804
GRLLCDTYLCSRDLLKEVSYSLT LA+TQL + RKEV+PH++P MFQ++ +L++L+EYGE
Sbjct: 442 GRLLCDTYLCSRDLLKEVSYSLTQLAETQLKKERKEVSPHDIPPMFQSSGALLKLVEYGE 501
Query: 805 TDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDK 864
TDA L++ELMF+LSVLPLTRQLTN+SGNLWGKTLQG+RAQRVEYLLLH FH +K+IVPDK
Sbjct: 502 TDACLALELMFHLSVLPLTRQLTNISGNLWGKTLQGSRAQRVEYLLLHAFHARKFIVPDK 561
Query: 865 FSNYAKETKLTKRRVTHGVDDGNFDDAD--INDANYHNDASESDHKKNKKAASYAGGLVL 922
F+ +KE TKR++ + D+AD I+D +H D K KK SYAGGLVL
Sbjct: 562 FAR-SKEFNSTKRKMNPDTEAARPDEADPSIDDEGHH-----VDQGKTKKGPSYAGGLVL 615
Query: 923 EPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSFPRLPSSKTTGVLPELLKK 982
EPKKGLYDKY+LLLDFNSLYPSIIQEYNICFTTV+RS+D + P LP+SKTTGVLPELLK
Sbjct: 616 EPKKGLYDKYVLLLDFNSLYPSIIQEYNICFTTVDRSADGNVPNLPASKTTGVLPELLKS 675
Query: 983 LVKLRREKKTWMKTASGLKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQ 1042
LV+ RR K+W+KTASGLKRQQ DI+QQALKLTANSMYGCLGFSNSRFYAKPLAELITLQ
Sbjct: 676 LVERRRMVKSWLKTASGLKRQQFDIQQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQ 735
Query: 1043 GREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKYRCLEI 1102
GREILQ+TVDLVQNNLNLEVIYGDTDSIMI++GLDDI++A I+ KVIQEVNKKYRCLEI
Sbjct: 736 GREILQNTVDLVQNNLNLEVIYGDTDSIMIHTGLDDISRAKGIAGKVIQEVNKKYRCLEI 795
Query: 1103 DLDGLYKRMLLLKKKKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQI 1162
DLDG+YKRMLLLKKKKYAA+KV DG+ E IERKGLD+VRRDWSLL+K++GDFCL QI
Sbjct: 796 DLDGIYKRMLLLKKKKYAAIKVAL-DGSLRENIERKGLDMVRRDWSLLSKEIGDFCLNQI 854
Query: 1163 LSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQ 1222
LSGGSC+DV+ESIH+SL++VQE+MR GQ LEKY+ITK+LTK PE YPDAKNQPHV VA
Sbjct: 855 LSGGSCDDVIESIHSSLVQVQEQMRGGQTELEKYIITKSLTKAPEDYPDAKNQPHVQVAL 914
Query: 1223 RLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGI-ALRARHPDELKQEQGTWL---IDI 1278
RLKQ GY SGCS GDT+PY+IC +Q S + I + RA+ E + T + I
Sbjct: 915 RLKQNGY-SGCSAGDTVPYIICSQQDSESTHSERIDSQRAQREPEGWKNLYTMVCLRILA 973
Query: 1279 DYYLSQQIHPVISRLCASI-QGTSPERLADCLGLDTSKFQHKSSEASDDPTSSLLFAGDD 1337
YYL Q+I+PV+SR+CA++ +GT P RLA+CLGLD+SKFQ + +E+ + TSS+L + D
Sbjct: 974 SYYLQQRINPVVSRVCAAVSRGTEPARLAECLGLDSSKFQSRLTESDNQDTSSMLLSVID 1033
Query: 1338 EESEK-----------PTSSGT------------------------DESDYNFWRKLCCP 1362
+E E+ P+ S T +++ NFWR++ CP
Sbjct: 1034 DEDERYRGCEPLRLSCPSCSTTFDCPPVSSLIIGSSSGNVSNPNEGNDASINFWRRMRCP 1093
Query: 1363 KC-FENGAGRISAAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDSER 1421
+C + R+S A++ANQ+KRQA+ F+ +YY+GLLMCDDE CK++T SV+ R++GDSER
Sbjct: 1094 RCPDDTDESRVSPAVLANQMKRQADSFINLYYKGLLMCDDEGCKYSTHSVNLRVMGDSER 1153
Query: 1422 GTVCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEKMEAKSRIPIEKELIKIRP 1481
GT+CPNYPRCNGHL R+YTEADLY+QLSYFC+V D +EK++ K+R+P EKE +
Sbjct: 1154 GTICPNYPRCNGHLVRQYTEADLYRQLSYFCYVVDATRCLEKLDQKARLPFEKEFAALSQ 1213
Query: 1482 IVDLAASTIQKIRDRCAFGWVKLQDLVVA 1510
++LA +QKIRDRCAFGWV+L+DL ++
Sbjct: 1214 TINLALMEVQKIRDRCAFGWVQLKDLAIS 1242
>DPOA_XENLA (Q9DE46) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1458
Score = 692 bits (1785), Expect = 0.0
Identities = 455/1166 (39%), Positives = 631/1166 (54%), Gaps = 134/1166 (11%)
Query: 388 YQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTKNE 447
Y SCCV VKN++R VY +P + KD + +S ++ +AV++ K +
Sbjct: 373 YVSCCVSVKNIERTVYLLP----RENRVQLSTGKDTG-APVSMMHVYQEFNEAVAE-KYK 426
Query: 448 IAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSFCAL 507
I K F V + YAFE D+PA Y+ ++ Y LP DLKG++F +
Sbjct: 427 IMK---------FKSKKVDKDYAFEIPDVPASSEYL-EVRYSADSPQLPQDLKGETFSHV 476
Query: 508 LGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSPSSS 567
G S+LELFL+ RKIKGPSWL++ S +SQ +SWCK E +V P +
Sbjct: 477 FGTNTSSLELFLLSRKIKGPSWLEIK--SPQLSSQPMSWCKVEAVVTRPDQVSVVKD--- 531
Query: 568 KITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGMLTHF 627
L PPVVV ++++KT N K + NEIV+ + + + +D +P THF
Sbjct: 532 ---LAPPPVVVLSLSMKTVQNAKTHQNEIVAIAALVHHTFPLDKAP-----PQPPFQTHF 583
Query: 628 TVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLVGHN 687
V+ KL+ IFP +N V +N + + +ER LL + ++HK+D DV+VGH+
Sbjct: 584 CVLSKLNDCIFPYDYNEAVKQKNAN-----IEIALTERTLLGFFLAKIHKIDPDVIVGHD 638
Query: 688 ISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVAGRL 747
I GFDL+VLL R +C+VP WSK+GRL RS MPKL R GF A + GR+
Sbjct: 639 IYGFDLEVLLQRINSCKVP--FWSKIGRLRRSVMPKLGGRS---GF----AERNAACGRI 689
Query: 748 LCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAKSLMELIEYGETDA 807
+CD + +++L++ SY L+ L L R + P + + + L+ ++E DA
Sbjct: 690 ICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYNDSVHLLYMLENTWIDA 749
Query: 808 WLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDKFSN 867
+++M L+VLPL Q+TN++GN+ +TL G R++R EYLLLH F + +IVPDK
Sbjct: 750 KFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAFTENNFIVPDK--- 806
Query: 868 YAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNK--KAASYAGGLVLEPK 925
+ K+ V+D ND +D KNK K A+YAGGLVLEPK
Sbjct: 807 -----PVFKKMQQTTVED--------------NDDMGTDQNKNKSRKKAAYAGGLVLEPK 847
Query: 926 KGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSS--------DDSFPRLPSSKTT-GVL 976
G YDK+ILLLDFNSLYPSIIQEYNICFTTV R + D P LP S G+L
Sbjct: 848 VGFYDKFILLLDFNSLYPSIIQEYNICFTTVHREAPSTQKGEDQDEIPELPHSDLEMGIL 907
Query: 977 PELLKKLVKLRREKKTWMKTASGLKRQ---QLDIEQQALKLTANSMYGCLGFSNSRFYAK 1033
P ++KLV+ RR K MK L Q DI Q+ALKLTANSMYGCLGFS SRFYAK
Sbjct: 908 PREIRKLVERRRHVKQLMKQPD-LNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAK 966
Query: 1034 PLAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEV 1093
PLA L+T QGREIL T ++VQ +NLEVIYGDTDSIMI + +++ + + +V E+
Sbjct: 967 PLAALVTHQGREILLHTKEMVQK-MNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEI 1025
Query: 1094 NKKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQ-FKDGTPYEVIERKGLDIVRRDWSLLAK 1152
NK Y+ LEID+DG++K +LLLKKKKYAA+ V+ DG E KGLDIVRRDW LAK
Sbjct: 1026 NKSYKLLEIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAK 1085
Query: 1153 DLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDA 1212
G++ ++QILS + +VE+I L ++ E + NG V + +Y I K LTK P+ YPD
Sbjct: 1086 QAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEINKALTKDPQDYPDK 1145
Query: 1213 KNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQG 1272
K+ PHV VA + QG GDTI YVIC Q GS+ SA+ + + E Q+Q
Sbjct: 1146 KSLPHVHVALWINSQGGRK-VKAGDTISYVIC--QDGSNLSAS----QRAYAQEQLQKQE 1198
Query: 1273 TWLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQHKSSEASDDPTSSLL 1332
ID YYLSQQ+HPV++R+C I G +A LGLD S+F+ D+ +LL
Sbjct: 1199 NLSIDTQYYLSQQVHPVVARICEPIDGIDSALIAMWLGLDPSQFRAHRHYQQDEENDALL 1258
Query: 1333 FAGDDEESEKPTSSGTDESDYNFWR--KLCCPKC----------------FENGAGRIS- 1373
S TDE Y K CPKC E G R S
Sbjct: 1259 GG---------PSQLTDEEKYRDCERFKFFCPKCGTENIYDNVFDGSGLQIEPGLKRCSK 1309
Query: 1374 ----------AAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDSERGT 1423
+ N++ +++ YY G L+C+++TC++ TR + S G
Sbjct: 1310 PECDASPLDYVIQVHNKLLLDIRRYIKKYYSGWLVCEEKTCQNRTRRLPLSF---SRNGP 1366
Query: 1424 VCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEK-MEAKSRIPIEKELI-KIRP 1481
+C + L +Y E LY QL ++ +FD +EK + + R ++K+L +
Sbjct: 1367 ICQACSKAT--LRSEYPEKALYTQLCFYRFIFDWDYALEKVVSEQERGHLKKKLFQESEN 1424
Query: 1482 IVDLAASTIQKIRDRCAFGWVKLQDL 1507
ST+ ++ R + V L L
Sbjct: 1425 QYKKLKSTVDQVLSRSGYSEVNLSKL 1450
>DPOA_HUMAN (P09884) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1462
Score = 685 bits (1767), Expect = 0.0
Identities = 443/1170 (37%), Positives = 640/1170 (53%), Gaps = 142/1170 (12%)
Query: 390 SCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTKNEIA 449
SCCV+VKN++R +Y +P N + + IS D ++ + ++ TK +I
Sbjct: 375 SCCVMVKNIERTLYFLPREMKIDLNTGKETG-----TPISMKDVYEEFDEKIA-TKYKIM 428
Query: 450 KHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSFCALLG 509
K F PV++ YAFE D+P Y+ ++ Y + LP DLKG++F + G
Sbjct: 429 K---------FKSKPVEKNYAFEIPDVPEKSEYL-EVKYSAEMPQLPQDLKGETFSHVFG 478
Query: 510 ARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSPSSSKI 569
S+LELFL+ RKIKGP WL+V + + +Q VSWCK E + P + S
Sbjct: 479 TNTSSLELFLMNRKIKGPCWLEVKK--STALNQPVSWCKVEAMALKPDLVNVIKDVSP-- 534
Query: 570 TLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGMLTHFTV 629
PP+VV A ++KT N K + NEI++ + + + +D +P +HF V
Sbjct: 535 ----PPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAA-----PKPPFQSHFCV 585
Query: 630 IRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLVGHNIS 689
+ K IFP F + +N+K V ++ER LL + ++HK+D D++VGHNI
Sbjct: 586 VSKPKDCIFPYAFKEVIEKKNVKVE-----VAATERTLLGFFLAKVHKIDPDIIVGHNIY 640
Query: 690 GFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVAGRLLC 749
GF+L+VLL R C+ P WSK+GRL RS MPKL R GFG A GR++C
Sbjct: 641 GFELEVLLQRINVCKAPH--WSKIGRLKRSNMPKLGGRS---GFGERNA----TCGRMIC 691
Query: 750 DTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAKSLMELIEYGETDAWL 809
D + +++L++ SY L+ L + L R + + M+ + L+ L+E+ DA
Sbjct: 692 DVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKF 751
Query: 810 SMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDKFSNYA 869
+++M L+VLPL Q+TN++GN+ +TL G R++R E+LLLH F++ YIVPDK
Sbjct: 752 ILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRK 811
Query: 870 KETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAGGLVLEPKKGLY 929
+ KL D + D + +KK +K +YAGGLVL+PK G Y
Sbjct: 812 PQQKL-------------------GDEDEEIDGDTNKYKKGRKKGAYAGGLVLDPKVGFY 852
Query: 930 DKYILLLDFNSLYPSIIQEYNICFTTVERSSDDS-----------FPRLPS-SKTTGVLP 977
DK+ILLLDFNSLYPSIIQE+NICFTTV+R + ++ P LP S G+LP
Sbjct: 853 DKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILP 912
Query: 978 ELLKKLVKLRREKKTWMKTASGLKRQ---QLDIEQQALKLTANSMYGCLGFSNSRFYAKP 1034
++KLV+ R++ K MK L Q DI Q+ALKLTANSMYGCLGFS SRFYAKP
Sbjct: 913 REIRKLVERRKQVKQLMKQQD-LNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKP 971
Query: 1035 LAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVN 1094
LA L+T +GREIL T ++VQ +NLEVIYGDTDSIMI + ++ + + KV EVN
Sbjct: 972 LAALVTYKGREILMHTKEMVQK-MNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVN 1030
Query: 1095 KKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQ-FKDGTPYEVIERKGLDIVRRDWSLLAKD 1153
K Y+ LEID+DG++K +LLLKKKKYAA+ V+ DG E KGLDIVRRDW LAKD
Sbjct: 1031 KLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKD 1090
Query: 1154 LGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAK 1213
G+F + QILS S + +VE+I L+++ E + NG V + ++ I K LTK P+ YPD K
Sbjct: 1091 TGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKK 1150
Query: 1214 NQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGT 1273
+ PHV VA + QG GDT+ YVIC Q GS+ +A+ RA P++L Q+Q
Sbjct: 1151 SLPHVHVALWINSQGGRK-VKAGDTVSYVIC--QDGSNLTASQ---RAYAPEQL-QKQDN 1203
Query: 1274 WLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQ----HKSSEASDDPTS 1329
ID YYL+QQIHPV++R+C I G +A LGLD ++F+ HK E +
Sbjct: 1204 LTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEE------N 1257
Query: 1330 SLLFAGDDEESEKPTSSGTDESDYNFWRKLCCP-------KCFEN---GAG--------R 1371
L G + TDE Y + CP ++N G+G R
Sbjct: 1258 DALLGGPAQL--------TDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYR 1309
Query: 1372 IS-----------AAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDSE 1420
S ++N++ +F+ YY G L+C++ TC++ TR + + S
Sbjct: 1310 CSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQF---SR 1366
Query: 1421 RGTVCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEKMEA-KSRIPIEKELIKI 1479
G +CP + L +Y++ LY QL ++ ++FD C +EK+ + ++K+
Sbjct: 1367 TGPLCPACMKAT--LQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTP 1424
Query: 1480 RPIVDL--AASTIQKIRDRCAFGWVKLQDL 1507
+ + D +T ++ R + V L L
Sbjct: 1425 KVLQDYRKLKNTAEQFLSRSGYSEVNLSKL 1454
>DPOA_RAT (O89042) DNA polymerase alpha catalytic subunit (EC 2.7.7.7)
(Fragment)
Length = 1451
Score = 672 bits (1733), Expect = 0.0
Identities = 435/1151 (37%), Positives = 634/1151 (54%), Gaps = 133/1151 (11%)
Query: 380 LFVWQGTLYQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQD 439
++V + SCCV+VKN++R +Y +P ++++ + + +P ++D
Sbjct: 372 VWVESAKTHVSCCVMVKNIERTLYFLPRE--------MKIDLNTGKETATPIT----MKD 419
Query: 440 AVSDTKNEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDL 499
+ ++I+ + F V++ YAFE D+P Y+ ++ Y + LP +L
Sbjct: 420 VYEEFDSKIS---AKYKIMKFKSKIVEKNYAFEIPDVPEKSEYL-EVRYSAEVPQLPQNL 475
Query: 500 KGKSFCALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDI 559
KG++F + G S+LELFL+ RKIKGP WL+V N + Q +SWCKFE + P +
Sbjct: 476 KGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLN--QPISWCKFEAMALKPDLV 533
Query: 560 RASSPSSSKITLVNPPVVVTAINLKTTINEKQNINEIVS-ASVVSCNMVKIDTPMLASEW 618
S PP+VV + ++KT N + + +EI++ A++V N P
Sbjct: 534 NVIKDVSP------PPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHNFPLDKAP------ 581
Query: 619 KRPGMLTHFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKM 678
+P THF V+ K IFP F + +N++ V ++ER LL + ++HK+
Sbjct: 582 PKPPFQTHFCVVSKPKDCIFPCAFKEVIKKKNMEVE-----VAATERTLLGFFLAKVHKL 636
Query: 679 DSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPA 738
D D+LVGHNI GF+L+VLL R C+VP WSK+GRL RS MPKL R GFG A
Sbjct: 637 DPDILVGHNICGFELEVLLQRINECKVP--FWSKIGRLRRSNMPKLGSRS---GFGERNA 691
Query: 739 IMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAKSLME 798
GR++CD + ++L+ SY L+ L + L R + + M+ L+
Sbjct: 692 ----TCGRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYSEPSHLLY 747
Query: 799 LIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKK 858
L+E+ DA +++M L+VLPL Q+TN++GN+ +TL G R++R E+LLLH F++
Sbjct: 748 LLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENN 807
Query: 859 YIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAG 918
YIVPDK ++ ++ D+ D D N +KK +K A+YAG
Sbjct: 808 YIVPDK--------QIFRKPQQKPGDEDEEIDGDTNK-----------YKKGRKKAAYAG 848
Query: 919 GLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSF-----------PRL 967
GLVL+PK G YDK+ILLLDFNSLYPSIIQE+NICFTTV+R + ++ P L
Sbjct: 849 GLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASETLKATEDEEQEQIPEL 908
Query: 968 PSSKTT-GVLPELLKKLVKLRREKKTWMKTASGLKRQ---QLDIEQQALKLTANSMYGCL 1023
P G+LP ++KLV+ R++ K MK L Q DI Q+ALKLTANSMYGCL
Sbjct: 909 PDPNLDMGILPREIRKLVERRKQVKQLMKQQD-LNPDLVLQYDIRQKALKLTANSMYGCL 967
Query: 1024 GFSNSRFYAKPLAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKAT 1083
GFS SRFYAKPLA L+T +GREIL T ++VQ +NLEVIYGDTDSIMI + ++ +
Sbjct: 968 GFSYSRFYAKPLAALVTYKGREILMHTKEMVQK-MNLEVIYGDTDSIMINTNSTNLEEVF 1026
Query: 1084 SISKKVIQEVNKKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQ-FKDGTPYEVIERKGLDI 1142
+ KV EVNK Y+ LEID+DG++K +LLLKKKKYAA+ V+ DG E KGLDI
Sbjct: 1027 KLGNKVKNEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDI 1086
Query: 1143 VRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTL 1202
VRRDW LAKD G+F + QILS S + +VE+I L+++ E + NG V + ++ I K L
Sbjct: 1087 VRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKAL 1146
Query: 1203 TKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRAR 1262
TK P+ YPD K+ PHV VA + QG GDT+ YVIC Q GS+ AT RA
Sbjct: 1147 TKDPQDYPDKKSLPHVHVALWINSQGGRK-VKAGDTVSYVIC--QDGSNLPAT---QRAY 1200
Query: 1263 HPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQHKSSE 1322
P++L Q+Q ID YYL+QQIHPV++R+C I G +A LGLD+++F + +
Sbjct: 1201 APEQL-QKQDNLAIDTQYYLAQQIHPVVARICEPIDGIDAVLIALWLGLDSTQF--RVHQ 1257
Query: 1323 ASDDPTSSLLFAGDDEESEKPTSSGTDESDYNFWRKL--CCPKC-----FEN---GAG-- 1370
D + L G + TDE Y K CP C ++N G+G
Sbjct: 1258 YHKDEENDALLGG--------PAQLTDEEKYKDCEKFKCLCPSCGTENIYDNVFEGSGMD 1309
Query: 1371 -------------RISAA----MIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSF 1413
+ S A ++N++ + + YY G L+C++ TC++ R +
Sbjct: 1310 MEPSLNRCSNIDCKASPATFMVQLSNKLIMDIRRCIKKYYDGWLICEEPTCRNRIRRLPL 1369
Query: 1414 RLVGDSERGTVCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEKMEAKSRIPIE 1473
S G +CP + L +Y++ LY QL ++ ++FD C +EK+ + ++
Sbjct: 1370 HF---SRNGPLCPACMK--AVLRPEYSDKSLYTQLCFYRYIFDADCALEKLPEHEKDKLK 1424
Query: 1474 KELIKIRPIVD 1484
K+ R + D
Sbjct: 1425 KQFFTPRVLQD 1435
>DPOA_MOUSE (P33609) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1465
Score = 667 bits (1722), Expect = 0.0
Identities = 435/1145 (37%), Positives = 622/1145 (53%), Gaps = 141/1145 (12%)
Query: 390 SCCVVVKNMQRCVYAIPSHPLHSTNEMIQLE-----KDVQESRISPADFRKKLQDAVSDT 444
SCCV+VKN++R +Y +P N + KDV E +F K+
Sbjct: 379 SCCVMVKNIERTLYFLPREMKFDLNTGKETAIPVTMKDVYE------EFDSKIS-----A 427
Query: 445 KNEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSF 504
K +I K F V++ YAFE D+P Y+ ++ Y + LP +LKG++F
Sbjct: 428 KYKIMK---------FKSKIVEKNYAFEIPDVPEKSEYL-EVRYSAEVPQLPQNLKGETF 477
Query: 505 CALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSP 564
+ G S+LELFL+ RKIKGP WL+V N + Q +SWCKFEV+ P +
Sbjct: 478 SHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLN--QPISWCKFEVMALKPDLVNVIKD 535
Query: 565 SSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGML 624
S PP+VV + ++KT N + + +EI++ + + + +D P
Sbjct: 536 VSP------PPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHSFALDKAP-----PEPPFQ 584
Query: 625 THFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLV 684
THF V+ K IFP F ++ +N+K + ++ER L+ + ++HK+D D+LV
Sbjct: 585 THFCVVSKPKDCIFPCDFKEVISKKNMKVE-----IAATERTLIGFFLAKVHKIDPDILV 639
Query: 685 GHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVA 744
GHNI F+L+VLL R C+VP WSK+GRL RS MPKL R GFG A
Sbjct: 640 GHNICSFELEVLLQRINECKVP--YWSKIGRLRRSNMPKLGSRS---GFGERNA----TC 690
Query: 745 GRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAKSLMELIEYGE 804
GR++CD + +++L+ SY L+ L + L R + + M+ + L+ L+E+
Sbjct: 691 GRMICDVEISAKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYSESSYLLYLLEHIW 750
Query: 805 TDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDK 864
DA +++M L+VLPL Q+TN++GN+ +TL G R++R E+LLLH F++ YIVPDK
Sbjct: 751 KDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDK 810
Query: 865 FSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAGGLVLEP 924
+ KL D + D + +KK +K A+YAGGLVL+P
Sbjct: 811 QIFRKPQQKL-------------------GDEDEEIDGDTNKYKKGRKKATYAGGLVLDP 851
Query: 925 KKGLYDKYILLLDFNSLYPSIIQEYNICFTTVER-----------SSDDSFPRLPSSKTT 973
K G YDK+ILLLDFNSLYPSIIQE+NICFTTV+R + P LP
Sbjct: 852 KVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPNLE 911
Query: 974 -GVLPELLKKLVKLRREKKTWMKTASGLKRQ---QLDIEQQALKLTANSMYGCLGFSNSR 1029
G+LP ++KLV+ R++ K MK L Q DI Q+ALKLTANSMYGCLGFS SR
Sbjct: 912 MGILPREIRKLVERRKQVKQLMKQQD-LNPDLVLQYDIRQKALKLTANSMYGCLGFSYSR 970
Query: 1030 FYAKPLAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKV 1089
FYAKPLA L+T +GREIL T D+VQ +NLEVIYGDTDSIMI + ++ + + KV
Sbjct: 971 FYAKPLAALVTYKGREILMHTKDMVQK-MNLEVIYGDTDSIMINTNSTNLEEVFKLGNKV 1029
Query: 1090 IQEVNKKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQ-FKDGTPYEVIERKGLDIVRRDWS 1148
EVNK Y+ LEID+D ++K +LLLKKKKYAA+ V+ DG E KGLDIVRRDW
Sbjct: 1030 KSEVNKLYKLLEIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWC 1089
Query: 1149 LLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEA 1208
LAKD G+F + QILS S + +VE+I L+++ E + NG V + ++ I K LTK P+
Sbjct: 1090 DLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQD 1149
Query: 1209 YPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELK 1268
YPD K+ PHV VA + QG GDT+ YVIC Q GS+ +AT RA P++L
Sbjct: 1150 YPDRKSLPHVHVALWINSQGGRK-VKAGDTVSYVIC--QDGSNLTAT---QRAYAPEQL- 1202
Query: 1269 QEQGTWLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQHKSSEASDDPT 1328
Q+ ID YYL+QQIHPV++R+C I G +A LGLD+++F + + D
Sbjct: 1203 QKLDNLAIDTQYYLAQQIHPVVARICEPIDGIDAVLIALWLGLDSTQF--RVHQYHKDEE 1260
Query: 1329 SSLLFAGDDEESEKPTSSGTDESDYNFWRKL--CCPKC-----FEN---GAG-------- 1370
+ L G + TDE Y K CP C ++N G+G
Sbjct: 1261 NDALLGG--------PAQLTDEEKYKDCEKFKCLCPSCGTENIYDNVFEGSGLDMEPSLY 1312
Query: 1371 -------RIS----AAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDS 1419
++S ++N++ + + YY G L+C++ TC R + S
Sbjct: 1313 RCSNVDCKVSPLTFMVQLSNKLIMDIRRCIKKYYDGWLICEEPTCCSRLRRLPLHF---S 1369
Query: 1420 ERGTVCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEKMEAKSRIPIEKELIKI 1479
G +CP + L +Y++ LY QL ++ ++FD C +EK+ + ++K+ +
Sbjct: 1370 RNGPLCPVCMK--AVLRPEYSDKSLYTQLCFYRYIFDADCALEKLTEHEKDKLKKQFFPL 1427
Query: 1480 RPIVD 1484
R + D
Sbjct: 1428 RVLQD 1432
>DPOA_OXYNO (Q94636) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1492
Score = 639 bits (1649), Expect = 0.0
Identities = 426/1163 (36%), Positives = 622/1163 (52%), Gaps = 131/1163 (11%)
Query: 377 GYSLFVWQGTLYQ-------SCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRIS 429
G LFV+ G +YQ SC + V MQR ++ +P S M E+ Q
Sbjct: 344 GADLFVF-GKIYQHEERKFVSCSIKVNGMQRELFVLPKMSGKSRAAMTTEEEKEQA---- 398
Query: 430 PADFRKKLQDAVSDTKNEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYL 489
RK + + K A ++ + PV RKYAFE I GE+ VKI Y
Sbjct: 399 ----RKVMMELEGVRKRFPA-------ITKWRCKPVTRKYAFE-LPIQHGEHQFVKIKYD 446
Query: 490 FKDTALPVDLKGKSFCALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKF 549
+LP ++G +F + GA S LE F++KRKI+GP W+ + N + +R +WCK
Sbjct: 447 ATFPSLPSTVQGNTFECIFGANQSMLESFILKRKIRGPCWMTIRNPQKVTDFRR-TWCKQ 505
Query: 550 EVIVDSPKDIRASSPSSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKI 609
E++V +PKDI + +K L PP+ +KT QN NEI S + +
Sbjct: 506 EILVSNPKDIEITLDDLNKTEL--PPLTSVTFAIKTC-RSSQNTNEIAMLSCIVNENISQ 562
Query: 610 DTPMLASEWKRPGMLTHFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLN 669
+ P K FT++RKLDG P+ + D+ + + ER L+
Sbjct: 563 EGPSKIDVHKS------FTLLRKLDGKPMPIEYERAFRDKK----DSFIQFFQHERQLIE 612
Query: 670 RLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMP--KLDRR 727
+ +++++D D++V HN+ G D+LL R Q ++ S WS++GRL ++ +P K D+
Sbjct: 613 AFVAKIYQLDPDLMVAHNLCGGMFDLLLARIQMLKI--SHWSRIGRLKKNQIPNKKSDQS 670
Query: 728 GKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVP 787
G +G G+ GRLL DT+L +++L++E +Y LTHLAK QL + R + +P
Sbjct: 671 GANYG-GSQWIPRQVTCGRLLVDTFLTAKELIRETNYDLTHLAKVQLQKDRIDFDDDLLP 729
Query: 788 KMFQTAKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVE 847
+ L +LI++ E DA+L+++LM +L V+PLT+QLTN++GNLW ++LQ ARA+R E
Sbjct: 730 TFYVQMAKLFQLIDHTEKDAYLTLQLMNHLQVIPLTKQLTNIAGNLWFRSLQNARAERNE 789
Query: 848 YLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDH 907
LLLHEF KKK+++PDK AK+ K F D Y ++
Sbjct: 790 MLLLHEFKKKKFVLPDKKQLNAKDLKKNM-----------FAD------EYEEGDGKTKG 832
Query: 908 KKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSFPR- 966
K KKAA YAGGLV+EPK G YD ILLLDFNSLYPSIIQEYN+CFTTV R +F
Sbjct: 833 GKRKKAA-YAGGLVIEPKAGFYDNIILLLDFNSLYPSIIQEYNLCFTTVNRRPTKNFDGS 891
Query: 967 ----------------------LPSSKTT---GVLPELLKKLVKLRREKKTWMKTASG-L 1000
LP VLP +L+ LV+ R+ K MKT +
Sbjct: 892 EMKNQYKKGENGEEEVDIEEADLPDKNVNLKDAVLPMVLRDLVQKRKAVKDKMKTEKDHV 951
Query: 1001 KRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNLNL 1060
K QL+I Q+A+KLTANSMYGCLGF +SRF+A+ +A LIT GRE L T D+ +N L
Sbjct: 952 KLSQLEIRQKAIKLTANSMYGCLGFGSSRFHAQAIAALITRTGRETLLRTKDIAENKLGF 1011
Query: 1061 EVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKYRCLEIDLDGLYKRMLLLKKKKYA 1120
V+YGDTDSIMI +G + + +A + K++ EVN Y+CLEI++DG++K +LLLKKKKYA
Sbjct: 1012 NVVYGDTDSIMINTGSNQLQQALEMGKRLKGEVNCLYKCLEIEIDGVFKSLLLLKKKKYA 1071
Query: 1121 AVKVQ-FKDGTPYEVI-ERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNS 1178
A+K + F +V+ E KGLD+VRRDW L+K +G + L QILSG E+VV +++
Sbjct: 1072 ALKYENFLSPAEVKVVQEMKGLDMVRRDWCPLSKRVGRYVLDQILSGKQREEVVLNLNEF 1131
Query: 1179 LMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDT 1238
L + E++ G + L +++ITK +TK Y D K QPHV VA+RL+ QG + V +
Sbjct: 1132 LSNIGNELKEGTIKLNEFIITKQITKAISDYNDIKGQPHVAVAKRLRDQGKSENQLVNNF 1191
Query: 1239 IPYVICCE-QGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASI 1297
IPYVIC + G ++ S+T ++ +A HPDE+ +G ID D+Y+S Q+ P I+RL I
Sbjct: 1192 IPYVICQQTYGDTTKSSTALSDKAYHPDEVISSRGKVTIDSDWYVSTQLLPPITRLIEHI 1251
Query: 1298 QGTSPERLADCLGLDTSKFQ-HKSSEASDDPTSSLLFAGD---DEESEKPTSSGTDES-- 1351
+G E +A CLGLD K++ H + +D+PT L + E+E+ + T
Sbjct: 1252 EGIEVEFVAQCLGLDPKKYRYHSEKKNTDNPTDDPLIVSNPVLQTETERSLKNRTVAELN 1311
Query: 1352 --------DYNF------------WRKLCCPKCFENGAGRISAAMIANQVKRQAEKFVLM 1391
+Y+F L C KC + RI A + N++ ++ +
Sbjct: 1312 IKCPHCAHNYHFPGILVPSSNNTELTGLACVKCNQ----RIPDAYMLNRLNLFLKQLTAL 1367
Query: 1392 YYRGLLMCDDETCKHTTRSVSFRLVGDSERGTVCPNYPRCNGHLNRKYTEADLYKQLSYF 1451
YY G+ C + C T + C C G +N +Y+E + L Y
Sbjct: 1368 YYLGMKECKEPQCGMKTNQLLL--------NNKC-IVKGCKGKMNSEYSELRINDTLRYL 1418
Query: 1452 CHVFDTVCYIEKMEAKSRIPIEK 1474
+F+ ++ + E K R EK
Sbjct: 1419 EGLFNVKKFLIENE-KYRKKYEK 1440
>DPOA_OXYTR (Q27152) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1513
Score = 631 bits (1627), Expect = e-180
Identities = 422/1155 (36%), Positives = 632/1155 (54%), Gaps = 132/1155 (11%)
Query: 377 GYSLFVWQGTLYQ-------SCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRIS 429
G L+++ G +YQ SC + V MQR +YA+P + +E++ Q+ R
Sbjct: 369 GTDLYIF-GKIYQPQMRQFVSCSMKVNGMQRELYALPKMR-GKARGALTVEEEKQQVR-- 424
Query: 430 PADFRKKLQDAVSDTKNEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYL 489
AV ++I K +S + PV RKYAFE I GE+ +KI Y
Sbjct: 425 ----------AVMMELDDIRKKRFPQ-ISKWRCKPVNRKYAFEMP-IQHGEHQFLKIKYD 472
Query: 490 FKDTALPVDLKGKSFCALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKF 549
LP ++G +F + G+ S LELF++KRKI+GP W+ + N T + +WC+
Sbjct: 473 STMPPLPSTIQGNTFECIFGSTQSMLELFILKRKIRGPCWMTIKN-PTKVTDFKKTWCRQ 531
Query: 550 EVIVDSPKDIRASSPSSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKI 609
+++D+PK++ + +K L PP+ + KTT +QN NEI +++SC I
Sbjct: 532 GIVIDNPKNVEVTLEDLNKQEL--PPLTSLTFSFKTT-RAQQNTNEI---AMISC---LI 582
Query: 610 DTPMLASEWKRPGMLTHFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLN 669
+T + + FT++RKLDG P F+ +V R N++ +ER ++
Sbjct: 583 NTNIAQEGPSQVERTQSFTLLRKLDGKPMPYDFDQKVKQRK----ENIIQKFENERQMIE 638
Query: 670 RLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMP--KLDRR 727
+ ++ +D D++V HN+ G D+LL R Q +V + WS++GRL ++ +P KLD
Sbjct: 639 AFIAKVFIVDPDLVVAHNLCGGMFDLLLARIQYLKV--NHWSRIGRLKKTQIPNKKLDFG 696
Query: 728 GKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVP 787
G ++G G+ GRLL DT+L +++L++E SY LT+LAK QL + R++ +P
Sbjct: 697 GSSYG-GSQWIPRQVTCGRLLVDTFLSAKELVRETSYDLTYLAKVQLKKDRQDFDDELLP 755
Query: 788 KMFQTAKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVE 847
++ T++ L LI++ E DA+L+++LM +L+++PLT QLTN++GNLW ++LQ ARA+R E
Sbjct: 756 TLYITSERLFSLIDHTEKDAYLTIQLMNHLAIIPLTLQLTNIAGNLWFRSLQNARAERNE 815
Query: 848 YLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDH 907
LLLHEF KKK+I+PDK + +AK+ K F D + S
Sbjct: 816 MLLLHEFKKKKFILPDKKAPFAKDFKRNM-----------FAD------EFEELKSGKGP 858
Query: 908 KKN--KKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSFP 965
KK +K A+YAGGLV+EPK G YD ILLLDFNSLYPSIIQEYN+CFTTV R +F
Sbjct: 859 KKGGKRKKAAYAGGLVIEPKAGFYDNIILLLDFNSLYPSIIQEYNLCFTTVNRRPTKNFD 918
Query: 966 R------------------------LPSSKTT---GVLPELLKKLVKLRREKKTWMKTAS 998
LP VLP +L+ LV+ R+ K MK
Sbjct: 919 GSEVKSQFKAAGTDANEGNEVEEADLPDKNVNVKDAVLPNVLRDLVQKRKAVKEKMKNEK 978
Query: 999 -GLKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNN 1057
+K QL+I Q+A+KLTANSMYGCLGF +SRF+A+ +A LIT GR+ L T D+ +N
Sbjct: 979 DAVKLSQLEIRQKAIKLTANSMYGCLGFGSSRFHAQAIAALITKTGRDTLLRTKDIAENK 1038
Query: 1058 LNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQ-EVNKKYRCLEIDLDGLYKRMLLLKK 1116
L V+YGDTDSIMI +G + + ++ + K+ ++ Y+CLEI++DG++K +LLLKK
Sbjct: 1039 LGFNVVYGDTDSIMINTGTNQLQQSLEMGKRPQGLKLIALYKCLEIEIDGVFKSLLLLKK 1098
Query: 1117 KKYAAVKVQFKDGTPYEVI--ERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVES 1174
KKYAA+K + GTP + E KGLD+VRRDW L+K++G+F L QILSG EDVV +
Sbjct: 1099 KKYAALKYE-GFGTPDAKVVQEVKGLDMVRRDWCPLSKNVGNFVLNQILSGKQREDVVLN 1157
Query: 1175 IHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCS 1234
++ L + E+M+N + L++++ITK LTK Y D K QPHV VAQRLK QG +
Sbjct: 1158 LNEYLSDIGEKMKNNGITLDQFIITKQLTKAISEYSDIKGQPHVAVAQRLKNQGKSESDL 1217
Query: 1235 VGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLC 1294
V + IPYVI + S + +A +A HP+E+ +G L+DI++Y++ Q+ P I+RL
Sbjct: 1218 VNNFIPYVIGAQPFDPSKTNPALAGKAYHPEEVVSSKGKILLDIEWYITMQVLPPITRLI 1277
Query: 1295 ASIQGTSPERLADCLGLDTSKFQHKSSEA------SDDPT--SSLLFAGDDEESEK---- 1342
I G E +A CLG+D K+++ SSE +DD T + + + E S K
Sbjct: 1278 EHIDGIDVEFVAQCLGVDPKKYKYHSSEKKTGETNNDDGTLIQNPILQTETERSLKGRTI 1337
Query: 1343 -------PTSSGT-------DESDYNFWRKLCCPKCFENGAGRISAAMIANQVKRQAEKF 1388
P S + + N L C KC + I A I N+V ++
Sbjct: 1338 AELTIKCPHCSESYHFPGIFQDGKNNTLSGLLCIKCTQP----IPEAYIQNRVTLFLKQL 1393
Query: 1389 VLMYYRGLLMCDDETCKHTTRSVSFRLVGDSERGTVCPNYPRCNGHLNRKYTEADLYKQL 1448
+ +YY+G C + C +R + + C N C + +YTE L
Sbjct: 1394 LTLYYQGNKQCQEPACGAVSRQLLY--------NNKCINL-ACKLKNDTRYTEQKTNDTL 1444
Query: 1449 SYFCHVFDTVCYIEK 1463
Y +F+ YI++
Sbjct: 1445 RYLQGLFNVKKYIQE 1459
>DPOA_SCHPO (P28040) DNA polymerase alpha catalytic subunit (EC
2.7.7.7) (DNA polymerase I)
Length = 1405
Score = 585 bits (1509), Expect = e-166
Identities = 399/1092 (36%), Positives = 580/1092 (52%), Gaps = 105/1092 (9%)
Query: 388 YQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTKNE 447
Y SC + V + R +Y +P S +E + D +E
Sbjct: 358 YVSCFLKVDGIMRSLYFLPRPSSSSVSE-------------------DSIAAQTKDVYDE 398
Query: 448 IAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSFCAL 507
+A L GV + K KYAFE D+P +Y+ ++ Y + ALP DL G SF +
Sbjct: 399 VANLLSKRGVKEWKSRVSKYKYAFELEDVPRTADYL-EVIYSYSYPALPTDLTGSSFSHV 457
Query: 508 LGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSPSSS 567
G + E F++ R++ GP WL++ A + SWC+ E+ SP++I S +
Sbjct: 458 FGTNTALFEQFVLSRRVMGPCWLKIQQ-PNFDAVKNASWCRVEIGCSSPQNISVSF-EKN 515
Query: 568 KITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGMLTHF 627
+IT PP+ V ++ +T IN++QN E+V S V I+ + A++ F
Sbjct: 516 EITSKTPPMTVMSLAFRTLINKEQNKQEVVMISARIFENVDIEKGLPANDMPSYS----F 571
Query: 628 TVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLVGHN 687
++IR L IFP GF E R K S++ C E SE +LLN + ++ D DV GH+
Sbjct: 572 SLIRPLK-QIFPNGF--EKLARQHK--SSIFC-ERSEVSLLNNFLNKVRTYDPDVYFGHD 625
Query: 688 ISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPK-LDRRGKTFGFGADPAIMSCVAGR 746
VLL R + ++ + WS +GRL RS P+ +R + F +AGR
Sbjct: 626 FE-MCYSVLLSRLKERKIHN--WSSIGRLRRSEWPRSFNRSSQQF------VEKQIIAGR 676
Query: 747 LLCD-TYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMF-QTAKSLMELIEYGE 804
L+CD + R ++K S+SL+ + +L+ R+++ + + + TA L++ + + E
Sbjct: 677 LMCDLSNDFGRSMIKAQSWSLSEIVLKELDIKRQDINQEKALQSWTDTAHGLLDYLVHCE 736
Query: 805 TDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDK 864
D + + F + +L L++ LTN++GN W +TL G RA+R EY+LLHEF K YIVPDK
Sbjct: 737 IDTFFIAAVAFKIQMLQLSKNLTNIAGNSWARTLTGTRAERNEYILLHEFKKNGYIVPDK 796
Query: 865 FSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAGGLVLEP 924
+ + + G +DG +++ KK Y GGLV EP
Sbjct: 797 ------QQSIRRHAEAFGAEDGLQEES-----------------LGKKKDKYKGGLVFEP 833
Query: 925 KKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERS-----SDDSFPRLPS-SKTTGVLPE 978
+KGLY+ IL++DFNSLYPSIIQEYNICFTTV+RS SDD P PS S G+ P
Sbjct: 834 QKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSDDQIPDTPSASANQGIFPR 893
Query: 979 LLKKLVKLRREKKTWMK--TASGLKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLA 1036
L+ LV+ RR+ K +K +A+ +R Q DI+QQALKLTANSMYGCLG++ SRFYA+PLA
Sbjct: 894 LIANLVERRRQIKGLLKDNSATPTQRLQWDIQQQALKLTANSMYGCLGYTKSRFYARPLA 953
Query: 1037 ELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKK 1096
LIT +GRE L +T +L + + L+VIYGDTDS+M+ + + D A I + ++VN++
Sbjct: 954 VLITYKGREALMNTKELA-DQMGLQVIYGDTDSVMLNTNVTDKNHALRIGNEFKEKVNER 1012
Query: 1097 YRCLEIDLDGLYKRMLLLKKKKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGD 1156
Y LEID+D +Y+RMLL KKKYAA+++ G P ++ KGLD+ RR++ LAK+
Sbjct: 1013 YSKLEIDIDNVYQRMLLHAKKKYAALQLD-SQGKPN--LDVKGLDMKRREFCTLAKEASK 1069
Query: 1157 FCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQP 1216
FCL QILSG E V+E+IH+ LM E+MRNG+ K++I L K PE YP+ K P
Sbjct: 1070 FCLDQILSGELTETVIENIHSYLMDFSEKMRNGKFPANKFIIFNRLGKNPEDYPNGKTMP 1129
Query: 1217 HVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLI 1276
V VA + K +G VGD IP++I S + A RA P E+ T +I
Sbjct: 1130 FVQVALKKKARG--ENVRVGDVIPFII-----AGSDADGHPADRAYSPQEIMNTNSTLVI 1182
Query: 1277 DIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSK-FQHKSSEAS------DDPTS 1329
D +YYLS QI P I R+ A I+GT+ RLA+CLGLD K + H++SE+S T
Sbjct: 1183 DYNYYLSHQILPPIERVIAPIEGTNRARLAECLGLDARKYYSHETSESSAFQRYESTLTD 1242
Query: 1330 SLLFAGDDEESEK-PTSSGTDES--DYNFWRKLCCPKCFENGAG-RISAAMIANQVKRQA 1385
F K P+ + T S ++ E G S I Q Q
Sbjct: 1243 DQCFINVSPLLLKCPSCNATSFSLRSVKSLKETLYANTVECDCGYEYSDFTIILQFSSQL 1302
Query: 1386 EKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDSERGTVCPNYPRCNGHLNRKYTEADLY 1445
F+ +YY G+L+CDD +C + TR +S G C N C G ++ +Y + LY
Sbjct: 1303 RDFINLYYEGILVCDDSSCGNRTRQMSV-------YGKRCCN-KSCRGSVHFEYNDEQLY 1354
Query: 1446 KQLSYFCHVFDT 1457
Q+ + T
Sbjct: 1355 NQIKFLLKAVQT 1366
>DPOA_DROME (P26019) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1488
Score = 574 bits (1480), Expect = e-163
Identities = 392/1104 (35%), Positives = 584/1104 (52%), Gaps = 115/1104 (10%)
Query: 389 QSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTKNEI 448
+S C+ V+N+ R +Y +P L + + K+ + +++ AD K+ V++
Sbjct: 390 KSVCLRVQNINRVLYLLPRQFL-----LDPISKEPTKQKVTVADIYKEFDSEVAN----- 439
Query: 449 AKHLVDLGVSSFSMAPVKRKYAFERT--DIPAGENYVVKINYLFKDTA--LPVDLKGKSF 504
L + F V + +A ++P +Y+ +++Y K L D K S
Sbjct: 440 -----QLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYL-EVHYDGKKPLPNLSADKKYNSI 493
Query: 505 CALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSP 564
+ GA +ALE FL+ RKIKGP WLQV+ F +SWC EV + PK++
Sbjct: 494 AHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTP--MSWCNTEVTLTEPKNVELVQD 551
Query: 565 SSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGML 624
PP+ + ++N++T++N K + NEI S+++ N ID P +P
Sbjct: 552 KGKPAP--PPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPA-----PQPAFN 604
Query: 625 THFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLV 684
H + + +P+ N E+ K S + SERALL+ + Q K+D+D++V
Sbjct: 605 RHMCALTRPAVVSWPLDLNFEMA----KYKSTTVHKHDSERALLSWFLAQYQKIDADLIV 660
Query: 685 GHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVA 744
+ L+V+ + A ++P WS++GRL R ++FG ++
Sbjct: 661 TFDSMDCQLNVITDQIVALKIPQ--WSRMGRL---------RLSQSFG----KRLLEHFV 705
Query: 745 GRLLCDTYLCSRDLLKEVSYSLTHLAKTQLN---QSRKEVAPHEVPKMFQTAKSLMELIE 801
GR++CD + + ++ SY L L K L R EV ++ +M++ +S+ +LI
Sbjct: 706 GRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLIS 765
Query: 802 YGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKYIV 861
D + LM L+++PL Q+TN+ GN +TLQG R++R E+LLLH FH+K YIV
Sbjct: 766 LTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIV 825
Query: 862 PDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAGGLV 921
PDK K +R G D AD + KK A+YAGGLV
Sbjct: 826 PDK--------KPVSKRSGAGDTDATLSGADAT-------------MQTKKKAAYAGGLV 864
Query: 922 LEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSD-DSFPRLPSSKT-TGVLPEL 979
LEP +GLY+KY+LL+DFNSLYPSIIQEYNICFTTV++ D D P LP SKT G+LP
Sbjct: 865 LEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPDSKTEPGILPLQ 924
Query: 980 LKKLVKLRREKKTWMKT--ASGLKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAE 1037
LK+LV+ R+E K M S + Q I Q ALKLTANSMYGCLGF++SRF+A+ LA
Sbjct: 925 LKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAA 984
Query: 1038 LITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKY 1097
L+T +GREIL +T LVQ +N +V+YGDTDS+MI + + D + I + Q VNK Y
Sbjct: 985 LVTHKGREILTNTQQLVQ-KMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLY 1043
Query: 1098 RCLEIDLDGLYKRMLLLKKKKYAAVKVQFKD--GTPYEVIERKGLDIVRRDWSLLAKDLG 1155
+ LE+D+DG++ +LLLKKKKYAA+K+ KD G E KGLDIVRRDWS LA +G
Sbjct: 1044 KQLELDIDGVFGCLLLLKKKKYAAIKLS-KDSKGNLRREQEHKGLDIVRRDWSQLAVMVG 1102
Query: 1156 DFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQ 1215
L ++LS E+ ++++H L K++ ++ G V L +VITK LT+ P+ Y ++ +
Sbjct: 1103 KAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASL 1162
Query: 1216 PHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWL 1275
PHV VA R+ ++ GD + YVIC + G+ RA H DELK + L
Sbjct: 1163 PHVQVALRMNRE-RNRRYKKGDMVDYVICLD-----GTTNAAMQRAYHLDELKTSEDKKL 1216
Query: 1276 -IDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQHKSSEASDDPT-----S 1329
+D +YYL QIHPV++R+ ++GT R+A+CLG+D +KF+ + + T
Sbjct: 1217 QLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGE 1276
Query: 1330 SLL--------------FAGDDEESEKPTSSGTDESDYNFWRKLC--CPKCFENGAGRIS 1373
SLL F ++E+ +S N + C K A
Sbjct: 1277 SLLKTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQY 1336
Query: 1374 AAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSVSFRLVGDSERGTVCPNYPRC-N 1432
A + NQ++ ++V +Y+ L+CD C TR+ S R + + P +C +
Sbjct: 1337 LASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLR------KKSHRPLCQKCRS 1390
Query: 1433 GHLNRKYTEADLYKQLSYFCHVFD 1456
G L R+YTE DLY QL Y +FD
Sbjct: 1391 GSLLRQYTERDLYNQLCYLRFMFD 1414
>DPOA_LEIDO (O00874) DNA polymerase alpha catalytic subunit (EC
2.7.7.7)
Length = 1339
Score = 523 bits (1347), Expect = e-147
Identities = 365/1001 (36%), Positives = 531/1001 (52%), Gaps = 145/1001 (14%)
Query: 386 TLYQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTK 445
T Y SCCV V+NM R V+ +P K + D
Sbjct: 276 TSYLSCCVRVRNMYRSVFVLP-----------------------------KAGSSQEDVV 306
Query: 446 NEIAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKG--KS 503
EI + G+ + V+R YAFE +P + K+ Y + P++ KG +
Sbjct: 307 KEINDICRNQGIEQRRIKFVERYYAFEVPGVPHEKTQWAKLRYPGRYP--PLNAKGPFRH 364
Query: 504 FCALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASS 563
++GA +S LELFLIKRK+KGPS+L++S +++ R+S C E V+SPK++RA
Sbjct: 365 ILIIMGASSSLLELFLIKRKLKGPSFLRISGL--VASANRISHCALEFSVESPKNLRAED 422
Query: 564 PSSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGM 623
L PP + +I + T ++ K NEI+ ASV V I+
Sbjct: 423 TK-----LPVPPFTLASIQIHTQLDSKGACNEILIASVAIYKDVNIEN------------ 465
Query: 624 LTHFTVIRKLDGNIF----PMGFNT----EVTDRNIKAGSNVLCVESSERALLNRLMLQL 675
IR + NI P +T ++ G + ++ERALL+ L QL
Sbjct: 466 -----TIRYIPDNILTGVRPASMSTPLPIDLESYCSAKGLPGVRRFANERALLDWLAQQL 520
Query: 676 HKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGA 735
K+D+D+++GHN GF LD+LL R Q + S WS +GRL+ +P+
Sbjct: 521 GKIDADMMIGHNFLGFTLDILLRRYQELSISS--WSTIGRLDLKRLPRFQGTATNVNQEK 578
Query: 736 DPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLA-KTQLNQSRKEVAPHE------VPK 788
+ I GRL+ D+Y SR+ K V+Y L LA + QL K E P
Sbjct: 579 ETCI-----GRLVVDSYSLSREHYKTVNYRLLSLADQMQLQGITKGSNNFEPGTSVLTPA 633
Query: 789 MFQTAKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEY 848
M ++ + +++ A LS ++ +L V+ LT++LT ++GNLW +TL GAR++R+EY
Sbjct: 634 MLSASRDIYDVLLQVCNCAVLSTAVVSHLDVIRLTKRLTTIAGNLWSRTLFGARSERIEY 693
Query: 849 LLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHK 908
LLLH FH K+I PD++ N+ + + +
Sbjct: 694 LLLHTFHDLKFITPDRYVQ-----------------------------NFKRGRDDEEEE 724
Query: 909 KNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSFPRLP 968
K+ A Y GG+VL+PK GLY YILLLDFNSLYPS+IQE+NICFTTV+R S P
Sbjct: 725 DGKRKAKYQGGMVLDPKCGLYSDYILLLDFNSLYPSLIQEFNICFTTVDRESGSEIDVPP 784
Query: 969 -------SSKTTG---------VLPELLKKLVKLRREKKTWMKTASGLKR-QQLDIEQQA 1011
S G VLP+++K LV RRE K MK L+I Q+A
Sbjct: 785 PENLICASCAAAGLSAPCLHKCVLPKVIKSLVDSRREVKRLMKIEKDANNLALLEIRQKA 844
Query: 1012 LKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLV-QNNLNLEVIYGDTDSI 1070
LKLTANSMYGCLGF SRF+A+PLAEL+T QGR LQSTVDL+ Q N +L VIYGDTDS+
Sbjct: 845 LKLTANSMYGCLGFEYSRFHAQPLAELVTRQGRLALQSTVDLIPQLNPSLRVIYGDTDSV 904
Query: 1071 MIYSGL-DDIAKATSISKKVIQEVNKKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQ--FK 1127
MI +G+ +DI + + ++NK+Y+ LEID+DG+++ +LLLKKKKYAA+ V
Sbjct: 905 MIQTGIKNDIKAVRDLGLDLKAKINKRYQSLEIDIDGVFRAILLLKKKKYAALTVTDWQG 964
Query: 1128 DGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMR 1187
+G Y+ E KGLD+VRRDW L+K + D L+++L+ ED+++ + N + V E++R
Sbjct: 965 EGKTYKK-EVKGLDMVRRDWCPLSKCVCDSVLSRVLNAEGSEDILDYVMNYMRDVSEKVR 1023
Query: 1188 NGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQ 1247
G+ L+ +VI+K+LTK PEAY + PH VA R+KQ+ VGD IPYVIC
Sbjct: 1024 AGRYTLDNFVISKSLTKEPEAY-RGNSFPHATVALRMKQR--KELVRVGDLIPYVIC--- 1077
Query: 1248 GGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQGTSPERLAD 1307
+ ++ +A H +E++Q ID ++YLS QI+P + RLC IQG S +L++
Sbjct: 1078 -----TGDRLSDKAFHVEEVRQ-NSQLQIDSEWYLSVQIYPPVMRLCEHIQGFSNAQLSE 1131
Query: 1308 CLGL---DTSKFQHKSSEASDDPTSSLLFAGDDEESEKPTS 1345
+G+ +K + + +E +D + S LF + E P +
Sbjct: 1132 AMGIACHTGAKLEEEEAETMNDFSHSSLFQSRNLEECFPAA 1172
>DPOA_YEAST (P13382) DNA polymerase alpha catalytic subunit (EC
2.7.7.7) (DNA polymerase I)
Length = 1468
Score = 522 bits (1344), Expect = e-147
Identities = 377/1132 (33%), Positives = 581/1132 (51%), Gaps = 139/1132 (12%)
Query: 442 SDTKNEIAKHLVD-LGVSSFSMAPVKRKYAFERTDIPAGENYV-VKINYLFKDTA---LP 496
+D EI L+D G+ + P K KY+FE DIP+ +Y+ V + Y ++ +P
Sbjct: 404 TDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLLPYQTPKSSRDTIP 463
Query: 497 VDLKGKSFCALLGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSP 556
DL +F + G ++ E F+I+ +I GP WL + + ++ + S C EV VD P
Sbjct: 464 SDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKG-ADFNSIRNASHCAVEVSVDKP 522
Query: 557 KDIRASSPSSSKITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLAS 616
++I +P+++K P + +++++T +N K+N EIVS ++ + + +D+P+
Sbjct: 523 QNI---TPTTTKTM---PNLRCLSLSIQTLMNPKENKQEIVSITLSAYRNISLDSPI--P 574
Query: 617 EWKRPGMLTHFTVIRKLDGNIFPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLH 676
E +P L T++R FP+G + + + + ++E+A+L+ L
Sbjct: 575 ENIKPDDLC--TLVRPPQSTSFPLGL-AALAKQKLPGRVRLF---NNEKAMLSCFCAMLK 628
Query: 677 KMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGAD 736
D DV++GH + LDVL HR +P+ +S +GR R T P+ RG + +
Sbjct: 629 VEDPDVIIGHRLQNVYLDVLAHRMHDLNIPT--FSSIGRRLRRTWPEKFGRGNS---NMN 683
Query: 737 PAIMSCV-AGRLLCDTYLCSRDLLKEVSYSLT------HLAKTQLNQSRKEVAPHEV--- 786
+S + +GRL+CD + E+ SLT L++ KE P ++
Sbjct: 684 HFFISDICSGRLICD-------IANEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQ 736
Query: 787 -PKMFQTAKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQR 845
P+ S+ ++ T+ +S E+ + + +L LT+QLTNL+GN W +TL G RA R
Sbjct: 737 NPQYQNDVNSMTMALQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGR 796
Query: 846 VEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASES 905
EY+LLHEF + +IVPDK N ++ K + N+ N +
Sbjct: 797 NEYILLHEFSRNGFIVPDKEGNRSRAQKQRQ-----------------NEEN-------A 832
Query: 906 DHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSD--DS 963
D N K A Y GGLV EP+KGL+ Y+L++DFNSLYPSIIQE+NICFTTV+R+ + D
Sbjct: 833 DAPVNSKKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDIDE 892
Query: 964 FPRLPSSKT-TGVLPELLKKLVKLRREKKTWMKTASG-LKRQQLDIEQQALKLTANSMYG 1021
P +P S+ GVLP LL LV RRE K MKT + KR Q DI QQALKLTANSMYG
Sbjct: 893 LPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYG 952
Query: 1022 CLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMIYSGLDDIAK 1081
CLG+ NSRFYAKPLA L+T +GREIL +T L + ++NL V+YGDTDS+MI +G D+ A
Sbjct: 953 CLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE-SMNLLVVYGDTDSVMIDTGCDNYAD 1011
Query: 1082 ATSISKKVIQEVNKKYRCLEIDLDGLYKRMLLLKKKKYAAVKVQF-KDGTPYEVIERKGL 1140
A I + VN++YR LEID+D ++K++LL KKKYAA+ V K+G V+E KGL
Sbjct: 1012 AIKIGLGFKRLVNERYRLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGL 1071
Query: 1141 DIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITK 1200
D+ RR++ L++D+ L ILS E+ ++ +++ L ++ ++ + ++KY I
Sbjct: 1072 DMKRREFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINM 1131
Query: 1201 TLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCE---QGGSSGSATGI 1257
L+K P+AYP KN P V VA R+++ G G I +VI + + A +
Sbjct: 1132 KLSKDPKAYPGGKNMPAVQVALRMRKAGRV--VKAGSVITFVITKQDEIDNAADTPALSV 1189
Query: 1258 ALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCLGLDTSKFQ 1317
A RA +E+ + + D YYL +QI + RL I + RL++ LGLD+ K+
Sbjct: 1190 AERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKYF 1249
Query: 1318 HKSSEASDDPTSSLLFAGDDEESEKP---TSSGTDESDYNFWRKLCCPKC---------F 1365
+ ++ G+D + +P T + + +L CP C
Sbjct: 1250 RREGGNNN---------GEDINNLQPLETTITDVERFKDTVTLELSCPSCDKRFPFGGIV 1300
Query: 1366 ENGAGRIS--------------AAMIANQVKRQAEKFVLMYYRGLLMCDDETCKHTTRSV 1411
+ R+S + +Q++ + +YY G L CDD TC TR V
Sbjct: 1301 SSNYYRVSYNGLQCKHCEQLFTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGIVTRQV 1360
Query: 1412 SFRLVGDSERGTVCPNYPRCNGHLNRKYTEADLYKQLSYFCHVFDTVCYIEKMEAKSRIP 1471
S G C N C G + KY++ LY QL YF +FD C K + I
Sbjct: 1361 SV-------FGKRCLN-DGCTGVMRYKYSDKQLYNQLLYFDSLFD--CEKNKKQELKPIY 1410
Query: 1472 IEKEL-----------IKI-----RPIVDLAASTIQKIRDRCAFGWVKLQDL 1507
+ +L IK R +++ S +QK + C +V + +
Sbjct: 1411 LPDDLDYPKEQLTESSIKALTEQNRELMETGRSVVQKYLNDCGRRYVDMTSI 1462
>DPOA_TRYBB (P27727) DNA polymerase alpha catalytic subunit (EC
2.7.7.7) (DNA polymerase I)
Length = 1339
Score = 513 bits (1321), Expect = e-144
Identities = 347/953 (36%), Positives = 524/953 (54%), Gaps = 126/953 (13%)
Query: 388 YQSCCVVVKNMQRCVYAIPSHPLHSTNEMIQLEKDVQESRISPADFRKKLQDAVSDTKNE 447
++SCCV ++++ R V+ +P ST+ + VQE N
Sbjct: 276 FRSCCVRIQHVHRNVFLLPKEG--STDAEV-----VQEI-------------------NA 309
Query: 448 IAKHLVDLGVSSFSMAPVKRKYAFERTDIPAGENYVVKINYLFKDTALPVDLKGKSFCAL 507
I + G+ + V+R YAFE +P +N K+ Y + P +
Sbjct: 310 ICR---GSGIEERRIKFVERYYAFEEPGVPREKNRWAKLVYPGRYPPFPNKGGLTHVQVV 366
Query: 508 LGARNSALELFLIKRKIKGPSWLQVSNFSTCSASQRVSWCKFEVIVDSPKDIRASSPSSS 567
+GA S LELFLIK+++ GPS+L++ + T A RVS CK E +V SPKDI+ + S
Sbjct: 367 VGASRSLLELFLIKKRLMGPSYLEIEHLVT--AMDRVSHCKTEFLVPSPKDIKVYNSSKP 424
Query: 568 KITLVNPPVVVTAINLKTTINEKQNINEIVSASVVSCNMVKIDTPMLASEWKRPGMLTHF 627
PP V +I L ++ NE+++AS+ V ID ++P + F
Sbjct: 425 P-----PPFTVASIQLHAQLDSDGVKNEVIAASIALYGDVSIDGE------RKPNITECF 473
Query: 628 TVIRKLDGNI-FPMGFNTEVTDRNIKAGSNVLCVESSERALLNRLMLQLHKMDSDVLVGH 686
T +R+L + P+ T + + + +ERALL L +D D++VGH
Sbjct: 474 TGVRQLSPDAPLPLDLETYCLSKRMPGVHRFI----NERALLTWFAETLAALDPDIIVGH 529
Query: 687 NISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFGADPAIMSCVAGR 746
NI G+ ++ LL+R Q + WS +GRL+ P++ +G F + +CV GR
Sbjct: 530 NIIGYTVETLLNRYQELNIVR--WSTIGRLDVRRFPRI--QGNNFNLAIEKE--ACV-GR 582
Query: 747 LLCDTYLCSRDLLKEVSYSLTHLAKTQ----LNQSRKEVAPHE---VPKMFQTAKSLMEL 799
L+ DTYL +R+ K +Y L L+ + +R P V ++++L +
Sbjct: 583 LVVDTYLLAREYYKSTNYKLLSLSTQMEIKGITDNRGHFEPGSTVLVKDSMMSSEALCPI 642
Query: 800 IEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHEFHKKKY 859
+ A LS + +L V+PLT++LT L+GNLW +TL GAR++R+EYLLLH FH K+
Sbjct: 643 LLQLLNCAVLSFNVASFLDVIPLTKRLTLLAGNLWSRTLYGARSERIEYLLLHAFHNLKF 702
Query: 860 IVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKAASYAGG 919
+ PDK KR + G +D D + K+ Y GG
Sbjct: 703 VTPDK----------KKRDLKRGRED--------------------DDDEGKRKTKYQGG 732
Query: 920 LVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSDDSFPRLP--------SSK 971
+VLEPK GLY +YILLLDFNSLYPS+IQE+N+C+TT++R + +P S +
Sbjct: 733 MVLEPKSGLYSEYILLLDFNSLYPSLIQEFNVCYTTIDRDENTVSAEVPPPESLICLSCR 792
Query: 972 TTG---------VLPELLKKLVKLRREKKTWMKTASGL-KRQQLDIEQQALKLTANSMYG 1021
G +LP++++ LV RRE K MK+ L+I Q ALKLTANSMYG
Sbjct: 793 AAGLPSPCLHKCILPKVIRGLVDSRREIKRMMKSEKDPGNLAMLEIRQLALKLTANSMYG 852
Query: 1022 CLGFSNSRFYAKPLAELITLQGREILQSTVDLV-QNNLNLEVIYGDTDSIMIYSGL-DDI 1079
CLGF SRFYA+PLAEL+T QGR LQ+TV+L+ Q + ++ VIYGDTDS+MI +G+ DDI
Sbjct: 853 CLGFEYSRFYAQPLAELVTRQGRLALQNTVELIPQISPSIRVIYGDTDSVMIQTGIKDDI 912
Query: 1080 AKATSISKKVIQEVNKKYRCLEIDLDGLYKRMLLLKKKKYAAVKV--QFKDGTPYEVIER 1137
K ++ ++ +VN++Y+ LE+D+DG+++ MLLL+KKKYAA+ V +G Y+ E
Sbjct: 913 VKVRNLGFEIKGKVNQRYQSLELDIDGVFRAMLLLRKKKYAALSVVDWQGEGKVYK-REV 971
Query: 1138 KGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQV-ALEKY 1196
KGLD+VRRDW L++ + D L +IL+ ED+++ + + V +++R+G V LE++
Sbjct: 972 KGLDMVRRDWCPLSQHVSDAVLKRILNAEGGEDILDFVIKYMKGVAQDVRSGNVYPLEEF 1031
Query: 1197 VITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATG 1256
VI+K+LTK PE+Y PH +VA R+KQ+ G VGD IPYVIC +G
Sbjct: 1032 VISKSLTKEPESY-HGTGYPHAVVALRMKQR--KEGVRVGDLIPYVIC--EGDEH----- 1081
Query: 1257 IALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQGTSPERLADCL 1309
I +A H DE+++ G +D+++YLS Q++P + RLC IQG PE+L++ +
Sbjct: 1082 IDDKAYHIDEVRRSDGL-SVDVEWYLSSQLYPPVMRLCEHIQGFVPEQLSEAM 1133
>DPOL_THEGO (P56689) DNA polymerase (EC 2.7.7.7) (TO POL)
Length = 773
Score = 222 bits (566), Expect = 5e-57
Identities = 182/642 (28%), Positives = 295/642 (45%), Gaps = 88/642 (13%)
Query: 660 VESSERALLNRLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRS 719
V S+E+ ++ R + + + D DVL+ +N FD L RS+ V LGR
Sbjct: 183 VVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFI----LGR--EG 236
Query: 720 TMPKLDRRGKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRK 779
+ PK+ R G F V GR+ D Y R + +Y+L + + Q ++
Sbjct: 237 SEPKIQRMGDRFAVE--------VKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKE 288
Query: 780 EVAPHEVPKMFQTAKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQ 839
+V E+ + ++T + L + Y DA ++ EL P+ QL+ L G +
Sbjct: 289 KVYAEEIAQAWETGEGLERVARYSMEDAKVTYELG--KEFFPMEAQLSRLVGQSLWDVSR 346
Query: 840 GARAQRVEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYH 899
+ VE+ LL + +++ + P+K E +L +RR
Sbjct: 347 SSTGNLVEWFLLRKAYERNELAPNK----PDERELARRR--------------------- 381
Query: 900 NDASESDHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERS 959
SYAGG V EP++GL++ I+ LDF SLYPSII +N+ T+ R
Sbjct: 382 --------------ESYAGGYVKEPERGLWEN-IVYLDFRSLYPSIIITHNVSPDTLNRE 426
Query: 960 SDDSFPRLPS------SKTTGVLPELLKKLVKLRREKKTWMK-TASGLKRQQLDIEQQAL 1012
+ + P G +P LL L++ R++ K MK T ++++ LD Q+A+
Sbjct: 427 GCEEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKVKKKMKATIDPIEKKLLDYRQRAI 486
Query: 1013 KLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNLNLEVIYGDTDSIMI 1072
K+ ANS YG G++ +R+Y K AE +T GR+ +++T+ ++ +V+Y DTD
Sbjct: 487 KILANSFYGYYGYAKARWYCKECAESVTAWGRQYIETTIREIEEKFGFKVLYADTDGFFA 546
Query: 1073 YSGLDDIAKATSISKKVIQEVNKKY-RCLEIDLDGLYKRMLLLKKKKYAAVKVQFKDGTP 1131
D +K+ + +N K LE++ +G YKR + KKKYA + + K
Sbjct: 547 TIPGADAETVKKKAKEFLDYINAKLPGLLELEYEGFYKRGFFVTKKKYAVIDEEDK---- 602
Query: 1132 YEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRNGQV 1191
I +GL+IVRRDWS +AK+ L IL G E+ V + +V E++ +V
Sbjct: 603 ---ITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIV----KEVTEKLSKYEV 655
Query: 1192 ALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQGGSS 1251
EK VI + +T+ + Y PHV VA+RL +G G I Y++ G
Sbjct: 656 PPEKLVIYEQITRDLKDY--KATGPHVAVAKRLAARGIK--IRPGTVISYIVLKGSG--- 708
Query: 1252 GSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRL 1293
I RA DE + + D +YY+ Q+ P + R+
Sbjct: 709 ----RIGDRAIPFDEFDPAKHKY--DAEYYIENQVLPAVERI 744
>DPOD_SOYBN (O48901) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1088
Score = 210 bits (535), Expect = 2e-53
Identities = 180/670 (26%), Positives = 315/670 (46%), Gaps = 87/670 (12%)
Query: 663 SERALLNRLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMP 722
+ER +L + ++D D+++G+NI FDL L+ R+ ++ + LGR+ S +
Sbjct: 334 TEREVLLAWRDFIREVDPDIIIGYNICKFDLPYLIERALNLKIAE--FPILGRIRNSRVR 391
Query: 723 KLDRRGKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVA 782
D + +G + V GR+ D + K SYSL ++ L++ +++V
Sbjct: 392 VKDTTFSSRQYGTRESKEVAVEGRVTFDLLQVMQRDYKLSSYSLNSVSSHFLSEQKEDVH 451
Query: 783 PHEVPKMFQT--AKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQG 840
H + Q A++ L Y DA+L L+ L + ++ ++G L
Sbjct: 452 -HSIISDLQNGNAETRRRLAVYCLKDAYLPQRLLDKLMFIYNYVEMARVTGVPISFLLSR 510
Query: 841 ARAQRVEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHN 900
++ +V LL +K ++P+ AK+ G + G F+
Sbjct: 511 GQSIKVLSQLLRRARQKNLVIPN-----AKQA---------GSEQGTFE----------- 545
Query: 901 DASESDHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSS 960
G VLE + G Y+K I LDF SLYPSI+ YN+C+ T+
Sbjct: 546 -----------------GATVLEARAGFYEKPIATLDFASLYPSIMMAYNLCYCTLVIPE 588
Query: 961 D--------DSFPRLPSSKT-------TGVLPELLKKLVKLRREKKTWMKTASG-LKRQQ 1004
D +S R PS +T G+LPE+L++L+ R+ K +K A L++
Sbjct: 589 DARKLNIPPESVNRTPSGETFVKSNLQKGILPEILEELLTARKRAKADLKEAKDPLEKAV 648
Query: 1005 LDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNL------ 1058
LD Q ALK++ANS+YG G + + ++ +T GR++++ T LV++
Sbjct: 649 LDGRQLALKISANSVYGFTGATIGQLPCLEISSSVTSYGRQMIEHTKKLVEDKFTTLNGY 708
Query: 1059 --NLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKY-RCLEIDLDGLYKRMLLLK 1115
N EVIYGDTDS+M+ G+ + +A ++ ++ + ++ + + ++++ + +Y LL+
Sbjct: 709 EHNAEVIYGDTDSVMVQFGVSAVEEAMNLGREAAEHISGTFTKPIKLEFEKVYYPYLLIS 768
Query: 1116 KKKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESI 1175
KK+YA + D ++ ++ KG++ VRRD LL K+L + CL +IL V+ +
Sbjct: 769 KKRYAGLFWTKPDN--FDKMDTKGIETVRRDNCLLVKNLVNDCLHKILIDRDIPGAVQYV 826
Query: 1176 HNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSV 1235
N++ ++ ++ L VITK LTK + Y HV +A+R++++ + +V
Sbjct: 827 KNAI----SDLLMNRMDLSLLVITKGLTKTGDDY--EVKAAHVELAERMRKRDAATAPNV 880
Query: 1236 GDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCA 1295
GD +PYVI +A G R D + + ID YYL QI I R+
Sbjct: 881 GDRVPYVII-------KAAKGAKAYERSEDPIYVLENNIPIDPHYYLENQISKPILRIFE 933
Query: 1296 SIQGTSPERL 1305
I + + L
Sbjct: 934 PILKNASKEL 943
>DPOD_ORYSA (Q9LRE6) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1105
Score = 207 bits (528), Expect = 1e-52
Identities = 174/646 (26%), Positives = 298/646 (45%), Gaps = 87/646 (13%)
Query: 675 LHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPKLDRRGKTFGFG 734
+ ++D D+++G+NI FDL L+ R++ ++ + LGR+ S + D + +G
Sbjct: 389 IREVDPDIIIGYNICKFDLPYLIERAEVLKIVE--FPILGRIRNSRVRVRDTTFSSRQYG 446
Query: 735 ADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTAK 794
+ V GR+ D + K SYSL ++ L + +++V H + Q
Sbjct: 447 MRESKDVAVEGRVQFDLLQAMQRDYKLSSYSLNSVSAHFLGEQKEDVH-HSIISDLQNGN 505
Query: 795 S--LMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLH 852
S L Y DA+L L+ L + ++ ++G L ++ +V LL
Sbjct: 506 SETRRRLAVYCLKDAYLPQRLLDKLMYIYNYVEMARVTGVPISFLLSRGQSIKVLSQLLR 565
Query: 853 EFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKK 912
+ +K ++P N AS D
Sbjct: 566 KAKQKNLVIP----------------------------------NIKGQASGQD------ 585
Query: 913 AASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERSSD--------DSF 964
++ G VLE + G Y+K I LDF SLYPSI+ YN+C+ T+ D +S
Sbjct: 586 --TFEGATVLEARAGFYEKPIATLDFASLYPSIMMAYNLCYCTLVPPEDARKLNLPPESV 643
Query: 965 PRLPSSKT-------TGVLPELLKKLVKLRREKKTWMKTASG-LKRQQLDIEQQALKLTA 1016
+ PS +T G+LPE+L++L+ R+ K +K A +R LD Q ALK++A
Sbjct: 644 NKTPSGETFVKPDVQKGILPEILEELLAARKRAKADLKEAKDPFERAVLDGRQLALKISA 703
Query: 1017 NSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNL--------NLEVIYGDTD 1068
NS+YG G + + ++ +T GR++++ T LV++ N EVIYGDTD
Sbjct: 704 NSVYGFTGATVGQLPCLEISSSVTSYGRQMIEHTKKLVEDKFTTLGGYEHNAEVIYGDTD 763
Query: 1069 SIMIYSGLDDIAKATSISKKVIQEVNKKY-RCLEIDLDGLYKRMLLLKKKKYAAVKVQFK 1127
S+M+ G+ + A + ++ ++ + + ++++ + +Y LL+ KK+YA + +
Sbjct: 764 SVMVQFGVSTVEDAMKLGREAADYISGTFIKPIKLEFEKIYFPYLLISKKRYAG--LYWT 821
Query: 1128 DGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMR 1187
+ ++ ++ KG++ VRRD LL K+L CL +IL V+ + N++ ++
Sbjct: 822 NPEKFDKMDTKGIETVRRDNCLLVKNLVTECLHKILVDRDVPGAVQYVKNTI----SDLL 877
Query: 1188 NGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQ 1247
+V L VITK LTK E Y A HV +A+R++++ + +VGD +PYVI
Sbjct: 878 MNRVDLSLLVITKGLTKTGEDY--AVKAAHVELAERMRKRDAATAPTVGDRVPYVII--- 932
Query: 1248 GGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRL 1293
+A G R D + ID YYL QI + R+
Sbjct: 933 ----KAAKGAKAYERSEDPIYVLDNNIPIDPQYYLENQISKPLLRI 974
>DPOD_MESAU (P97283) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1103
Score = 203 bits (517), Expect = 3e-51
Identities = 185/651 (28%), Positives = 307/651 (46%), Gaps = 92/651 (14%)
Query: 678 MDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLN--RSTMPKLDRRGKTFGFGA 735
MD DV+ G+NI FDL L+ R+Q +V + LGR+ RS + + + G
Sbjct: 384 MDPDVITGYNIQNFDLPYLISRAQTLKV--DRFPFLGRVTGLRSNIRDSSFQSRQVG-RR 440
Query: 736 DPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTA-- 793
D ++S V GR+ D K SY+L ++ L + +++V H + Q
Sbjct: 441 DSKVVSMV-GRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ-HSIITDLQNGNE 498
Query: 794 KSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHE 853
++ L Y DA+L + L+ L VL ++ ++G G L + +V LL +
Sbjct: 499 QTRRRLAVYCLRDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRGQQVKVVSQLLRQ 558
Query: 854 FHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKA 913
++ ++P + K T G +D
Sbjct: 559 AMRQGLLMP-----------VVK---TEGGED---------------------------- 576
Query: 914 ASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERS--------SDDSFP 965
Y G V+EP KG YD I LDF+SLYPSI+ +N+C+TT+ R D F
Sbjct: 577 --YTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFI 634
Query: 966 RLP-------SSKTTGVLPELLKKLVKLRREKKTWM-KTASGLKRQQLDIEQQALKLTAN 1017
+ P SS G+LP++L+ L+ R+ K + + L+RQ LD Q ALK++AN
Sbjct: 635 KTPTGDEFVKSSVRKGLLPQILENLLSARKRAKAELAQETDPLRRQVLDGRQLALKVSAN 694
Query: 1018 SMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQN--------NLNLEVIYGDTDS 1069
S+YG G + +++ +T GR++++ T LV++ N N +V+YGDTDS
Sbjct: 695 SVYGFTGAEVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTLENGYNANAKVVYGDTDS 754
Query: 1070 IMIYSGLDDIAKATSISKKVIQEVNKKYRC-LEIDLDGLYKRMLLLKKKKYAAVKVQFKD 1128
+M G+ +A+A S+ ++ V+ + + ++ + +Y LL+ KK+YA + +
Sbjct: 755 VMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSQP 814
Query: 1129 GTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRN 1188
T ++ ++ KGL+ VRRD L +L L +IL + V + V ++
Sbjct: 815 DT-HDRMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKD----VISDLLC 869
Query: 1189 GQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQG 1248
++ + + VITK LT+ Y A Q HV +A+R++++ S S+GD +PYVI
Sbjct: 870 NRIDISQLVITKELTRAAADY--AGKQAHVELAERMRKRDPGSAPSLGDRVPYVII---- 923
Query: 1249 GSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQG 1299
G+A G+A + D L + + ID YYL QQ+ + R+ I G
Sbjct: 924 ---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLGQQLAKPLLRIFEPILG 971
>DPOD_BOVIN (P28339) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1106
Score = 202 bits (514), Expect = 6e-51
Identities = 188/671 (28%), Positives = 314/671 (46%), Gaps = 94/671 (14%)
Query: 660 VESSERA--LLNRLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLN 717
V+S ER LL + MD DV+ G+NI FDL L+ R+Q +VP + LGR+
Sbjct: 367 VQSYEREEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVPG--FPLLGRVI 424
Query: 718 --RSTMPKLDRRGKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLN 775
RS + + + + G D ++S V GR+ D K SY+L ++ L
Sbjct: 425 GLRSNIRESSFQSRQTG-RRDSKVVSMV-GRVQMDMLQVLLREYKLRSYTLNAVSFHFLG 482
Query: 776 QSRKEVAPHEVPKMFQTA--KSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNL 833
+ +++V H + Q ++ L Y DA+L + L+ L VL ++ ++G
Sbjct: 483 EQKEDVQ-HSIITDLQNGNDQTRRRLAVYCLKDAFLPLRLLERLMVLVNAMEMARVTGVP 541
Query: 834 WGKTLQGARAQRVEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADI 893
G L + +V LL + ++ ++P + K T G +D
Sbjct: 542 LGYLLSRGQQVKVVSQLLRQAMRQGLLMP-----------VVK---TEGGED-------- 579
Query: 894 NDANYHNDASESDHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICF 953
Y G V+EP KG YD I LDF+SLYPSI+ +N+C+
Sbjct: 580 ----------------------YTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCY 617
Query: 954 TTVERS--------SDDSFPRLP-------SSKTTGVLPELLKKLVKLRREKKTWM-KTA 997
TT+ R ++D F + P +S G+LP++L+ L+ R+ K + K
Sbjct: 618 TTLLRPGAAQKLGLTEDQFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAKAELAKET 677
Query: 998 SGLKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNN 1057
L+RQ LD Q ALK++ANS+YG G R +++ +T GR++++ T LV+
Sbjct: 678 DPLRRQVLDGRQLALKVSANSVYGFTGAQVGRLPCLEISQSVTGFGRQMIEKTKQLVETK 737
Query: 1058 LNLE--------VIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKYRC-LEIDLDGLY 1108
+E V+YGDTDS+M G+ +A+A ++ ++ V+ + + ++ + +Y
Sbjct: 738 YTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVY 797
Query: 1109 KRMLLLKKKKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSC 1168
LL+ KK+YA + + ++ ++ KGL+ VRRD L +L L ++L
Sbjct: 798 FPYLLISKKRYAGLLFSSRPDA-HDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDP 856
Query: 1169 EDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQG 1228
V + V ++ ++ + + VITK LT+ Y A Q HV +A+R++++
Sbjct: 857 SGAVAHAQD----VISDLLCNRIDISQLVITKELTRAAADY--AGKQAHVELAERMRKRD 910
Query: 1229 YTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHP 1288
S S+GD +PYVI +A G+A + D L + + ID YYL QQ+
Sbjct: 911 PGSAPSLGDRVPYVII-------SAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAK 963
Query: 1289 VISRLCASIQG 1299
+ R+ I G
Sbjct: 964 PLLRIFEPILG 974
>DPOD_MOUSE (P52431) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1105
Score = 202 bits (513), Expect = 7e-51
Identities = 184/651 (28%), Positives = 307/651 (46%), Gaps = 92/651 (14%)
Query: 678 MDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLN--RSTMPKLDRRGKTFGFGA 735
MD DV+ G+NI FDL L+ R+QA +V + LGR+ RS + + + G
Sbjct: 386 MDPDVITGYNIQNFDLPYLISRAQALKV--DRFPFLGRVTGLRSNIRDSSFQSRQVG-RR 442
Query: 736 DPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAPHEVPKMFQTA-- 793
D ++S V GR+ D K SY+L ++ L + +++V H + Q
Sbjct: 443 DSKVISMV-GRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ-HSIITDLQNGNE 500
Query: 794 KSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGARAQRVEYLLLHE 853
++ L Y DA+L + L+ L VL ++ ++G G L + +V LL +
Sbjct: 501 QTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRGQQVKVVSQLLRQ 560
Query: 854 FHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHNDASESDHKKNKKA 913
++ ++P + K T G +D
Sbjct: 561 AMRQGLLMP-----------VVK---TEGGED---------------------------- 578
Query: 914 ASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERS--------SDDSFP 965
Y G V+EP KG YD I LDF+SLYPSI+ +N+C+TT+ R D F
Sbjct: 579 --YTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFI 636
Query: 966 RLP-------SSKTTGVLPELLKKLVKLRREKKTWM-KTASGLKRQQLDIEQQALKLTAN 1017
+ P SS G+LP++L+ L+ R+ K + + L+RQ LD Q ALK++AN
Sbjct: 637 KTPTGDEFVKSSVRKGLLPQILENLLSARKRAKAELAQETDPLRRQVLDGRQLALKVSAN 696
Query: 1018 SMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQN--------NLNLEVIYGDTDS 1069
S+YG G + +++ +T GR++++ T LV++ + N +V+YGDTDS
Sbjct: 697 SVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYDANAKVVYGDTDS 756
Query: 1070 IMIYSGLDDIAKATSISKKVIQEVNKKYRC-LEIDLDGLYKRMLLLKKKKYAAVKVQFKD 1128
+M G+ +A+A S+ ++ V+ + + ++ + +Y LL+ KK+YA + +
Sbjct: 757 VMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRS 816
Query: 1129 GTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIHNSLMKVQEEMRN 1188
++ ++ KGL+ VRRD L +L L +IL + V + V ++
Sbjct: 817 DA-HDKMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKD----VISDLLC 871
Query: 1189 GQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVGDTIPYVICCEQG 1248
++ + + VITK LT+ Y A Q HV +A+R++++ S S+GD +PYVI
Sbjct: 872 NRIDISQLVITKELTRAAADY--AGKQAHVELAERMRKRDPGSAPSLGDRVPYVII---- 925
Query: 1249 GSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCASIQG 1299
G+A G+A + D L + + ID YYL QQ+ + R+ I G
Sbjct: 926 ---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILG 973
>DPOD_ARATH (Q9LVN7) DNA polymerase delta catalytic subunit (EC
2.7.7.7)
Length = 1081
Score = 199 bits (507), Expect = 4e-50
Identities = 180/671 (26%), Positives = 314/671 (45%), Gaps = 96/671 (14%)
Query: 654 GSNVLCVESSERALLNRLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKL 713
G +V+ E+ LL L + +D D+++G+NI FDL L+ R+ + + L
Sbjct: 359 GVDVMSFETEREVLLAWRDL-IRDVDPDIIIGYNICKFDLPYLIERAATLGIEE--FPLL 415
Query: 714 GRLNRSTMPKLDRRGKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQ 773
GR+ S + D + G + + + GR D K SYSL ++
Sbjct: 416 GRVKNSRVRVRDSTFSSRQQGIRESKETTIEGRFQFDLIQAIHRDHKLSSYSLNSVSAHF 475
Query: 774 LNQSRKEVAPHEVPKMFQT--AKSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSG 831
L++ +++V H + Q A++ L Y DA+L L+ L + ++ ++G
Sbjct: 476 LSEQKEDVH-HSIITDLQNGNAETRRRLAVYCLKDAYLPQRLLDKLMFIYNYVEMARVTG 534
Query: 832 NLWGKTLQGARAQRVEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDA 891
L ++ +V LL + +K ++P+ AK++ G + G
Sbjct: 535 VPISFLLARGQSIKVLSQLLRKGKQKNLVLPN-----AKQS---------GSEQG----- 575
Query: 892 DINDANYHNDASESDHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNI 951
+Y G VLE + G Y+K I LDF SLYPSI+ YN+
Sbjct: 576 -----------------------TYEGATVLEARTGFYEKPIATLDFASLYPSIMMAYNL 612
Query: 952 CFTTVERSSD--------DSFPRLPSSKT-------TGVLPELLKKLVKLRREKKTWMKT 996
C+ T+ D + + PS +T G+LPE+L++L+ R+ K +K
Sbjct: 613 CYCTLVTPEDVRKLNLPPEHVTKTPSGETFVKQTLQKGILPEILEELLTARKRAKADLKE 672
Query: 997 ASG-LKRQQLDIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQ 1055
A L++ LD Q ALK++ANS+YG G + + ++ +T GR++++ T LV+
Sbjct: 673 AKDPLEKAVLDGRQLALKISANSVYGFTGATVGQLPCLEISSSVTSYGRQMIEQTKKLVE 732
Query: 1056 NNL--------NLEVIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKY-RCLEIDLDG 1106
+ N EVIYGDTDS+M+ G+ D+ A ++ ++ + ++ + + ++++ +
Sbjct: 733 DKFTTLGGYQYNAEVIYGDTDSVMVQFGVSDVEAAMTLGREAAEHISGTFIKPIKLEFEK 792
Query: 1107 LYKRMLLLKKKKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSG- 1165
+Y LL+ KK+YA + + + ++ ++ KG++ VRRD LL K+L L +IL
Sbjct: 793 VYFPYLLINKKRYAG--LLWTNPQQFDKMDTKGIETVRRDNCLLVKNLVTESLNKILIDR 850
Query: 1166 ---GSCEDVVESIHNSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQ 1222
G+ E+V ++I + LM ++ L VITK LTK + Y H +A+
Sbjct: 851 DVPGAAENVKKTISDLLM--------NRIDLSLLVITKGLTKTGDDY--EVKSAHGELAE 900
Query: 1223 RLKQQGYTSGCSVGDTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYL 1282
R++++ + +VGD +PYVI +A G R D + Q ID +YYL
Sbjct: 901 RMRKRDAATAPNVGDRVPYVII-------KAAKGAKAYERSEDPIYVLQNNIPIDPNYYL 953
Query: 1283 SQQIHPVISRL 1293
QI + R+
Sbjct: 954 ENQISKPLLRI 964
>DPOD_HUMAN (P28340) DNA polymerase delta catalytic subunit (EC
2.7.7.7) (DNA polymerase delta subunit p125)
Length = 1107
Score = 196 bits (498), Expect = 4e-49
Identities = 177/663 (26%), Positives = 301/663 (44%), Gaps = 88/663 (13%)
Query: 664 ERALLNRLMLQLHKMDSDVLVGHNISGFDLDVLLHRSQACRVPSSMWSKLGRLNRSTMPK 723
E LL + MD DV+ G+NI FDL L+ R+Q +V + + LGR+
Sbjct: 374 EEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF--LGRVAGLCSNI 431
Query: 724 LDRRGKTFGFGADPAIMSCVAGRLLCDTYLCSRDLLKEVSYSLTHLAKTQLNQSRKEVAP 783
D ++ G + + GR+ D K SY+L ++ L + +++V
Sbjct: 432 RDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQ- 490
Query: 784 HEVPKMFQTA--KSLMELIEYGETDAWLSMELMFYLSVLPLTRQLTNLSGNLWGKTLQGA 841
H + Q ++ L Y DA+L + L+ L VL ++ ++G L
Sbjct: 491 HSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRG 550
Query: 842 RAQRVEYLLLHEFHKKKYIVPDKFSNYAKETKLTKRRVTHGVDDGNFDDADINDANYHND 901
+ +V LL + + ++P
Sbjct: 551 QQVKVVSQLLRQAMHEGLLMPVV------------------------------------- 573
Query: 902 ASESDHKKNKKAASYAGGLVLEPKKGLYDKYILLLDFNSLYPSIIQEYNICFTTVERS-- 959
K++ Y G V+EP KG YD I LDF+SLYPSI+ +N+C+TT+ R
Sbjct: 574 -------KSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGT 626
Query: 960 ------SDDSFPRLP-------SSKTTGVLPELLKKLVKLRREKKTWM-KTASGLKRQQL 1005
++D F R P +S G+LP++L+ L+ R+ K + K L+RQ L
Sbjct: 627 AQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVL 686
Query: 1006 DIEQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGREILQSTVDLVQNNLNLE---- 1061
D Q ALK++ANS+YG G + +++ +T GR++++ T LV++ +E
Sbjct: 687 DGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYS 746
Query: 1062 ----VIYGDTDSIMIYSGLDDIAKATSISKKVIQEVNKKYRC-LEIDLDGLYKRMLLLKK 1116
V+YGDTDS+M G+ +A+A ++ ++ V+ + + ++ + +Y LL+ K
Sbjct: 747 TSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISK 806
Query: 1117 KKYAAVKVQFKDGTPYEVIERKGLDIVRRDWSLLAKDLGDFCLTQILSGGSCEDVVESIH 1176
K+YA + + ++ ++ KGL+ VRRD L +L L ++L E V
Sbjct: 807 KRYAGLLFSSRPDA-HDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQ 865
Query: 1177 NSLMKVQEEMRNGQVALEKYVITKTLTKPPEAYPDAKNQPHVLVAQRLKQQGYTSGCSVG 1236
+ V ++ ++ + + VITK LT+ Y A Q HV +A+R++++ S S+G
Sbjct: 866 D----VISDLLCNRIDISQLVITKELTRAASDY--AGKQAHVELAERMRKRDPGSAPSLG 919
Query: 1237 DTIPYVICCEQGGSSGSATGIALRARHPDELKQEQGTWLIDIDYYLSQQIHPVISRLCAS 1296
D +PYVI +A G+A + D L + + ID YYL QQ+ + R+
Sbjct: 920 DRVPYVII-------SAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEP 972
Query: 1297 IQG 1299
I G
Sbjct: 973 ILG 975
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.337 0.147 0.483
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 166,031,320
Number of Sequences: 164201
Number of extensions: 6851110
Number of successful extensions: 28894
Number of sequences better than 10.0: 99
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 28122
Number of HSP's gapped (non-prelim): 272
length of query: 1510
length of database: 59,974,054
effective HSP length: 123
effective length of query: 1387
effective length of database: 39,777,331
effective search space: 55171158097
effective search space used: 55171158097
T: 11
A: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.7 bits)
S2: 73 (32.7 bits)
Medicago: description of AC144431.4