BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144345.6 - phase: 0
(360 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24... 136 9e-32
MM26_HUMAN (Q9NRE1) Matrix metalloproteinase-26 precursor (EC 3.... 81 4e-15
MM12_MOUSE (P34960) Macrophage metalloelastase precursor (EC 3.4... 72 2e-12
MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC 3.... 72 2e-12
MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1 pr... 71 4e-12
MM12_RAT (Q63341) Macrophage metalloelastase precursor (EC 3.4.2... 71 5e-12
MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.... 70 6e-12
MM24_HUMAN (Q9Y5R2) Matrix metalloproteinase-24 precursor (EC 3.... 70 1e-11
MM16_RAT (O35548) Matrix metalloproteinase-16 precursor (EC 3.4.... 70 1e-11
MM16_MOUSE (Q9WTR0) Matrix metalloproteinase-16 precursor (EC 3.... 70 1e-11
MM07_HUMAN (P09237) Matrilysin precursor (EC 3.4.24.23) (Pump-1 ... 69 1e-11
MM16_HUMAN (P51512) Matrix metalloproteinase-16 precursor (EC 3.... 69 2e-11
MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 69 2e-11
MM13_BOVIN (O77656) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 69 2e-11
HE_HEMPU (P91953) Hatching enzyme precursor (EC 3.4.24.12) (HE) ... 69 2e-11
MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC 3.... 68 3e-11
MM24_RAT (Q99PW6) Matrix metalloproteinase-24 precursor (EC 3.4.... 68 4e-11
MM24_MOUSE (Q9R0S2) Matrix metalloproteinase-24 precursor (EC 3.... 68 4e-11
MM13_XENLA (Q10835) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 67 5e-11
MM07_MOUSE (Q10738) Matrilysin precursor (EC 3.4.24.23) (Pump-1 ... 67 7e-11
>MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24.-)
(SMEP1)
Length = 305
Score = 136 bits (342), Expect = 9e-32
Identities = 91/260 (35%), Positives = 129/260 (49%), Gaps = 28/260 (10%)
Query: 79 YKGVDQIKQYLSDFGYLEQSGPFNNTLDQETVLALKTYQRYFNIQQDTLSEI--LQHIAL 136
YKG+ +K Y GY+ + F++ D V A+KTYQ+ +N+ +I L+ I
Sbjct: 51 YKGLSNVKNYFHHLGYIPNAPHFDDNFDDTLVSAIKTYQKNYNLNVTGKFDINTLKQIMT 110
Query: 137 PRCGVPDRILKYNLT------NDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRT 190
PRCGVPD I+ N T +D +F K + GT LTY F P ++ +
Sbjct: 111 PRCGVPDIIINTNKTTSFGMISDYTFFKDMPRWQAGTTQLTYAFSPEPRLDDTFKSAIAR 170
Query: 191 ALTQWSNTTRVLNFTETKSYDDANIKIGFYNITDDD-----GINDVAVGFTFIVLDSTNV 245
A ++W+ + F ET SY+ ANIKI F + D G + +G F D
Sbjct: 171 AFSKWTPVVNIA-FQETTSYETANIKILFASKNHGDPYPFDGPGGI-LGHAFAPTD---- 224
Query: 246 KSGFITLDATKYWALPTE------HRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILP 299
G DA +YW + FDLE+ A+H+IGHLLGL HSSD ++IMYP+I P
Sbjct: 225 --GRCHFDADEYWVASGDVTKSPVTSAFDLESVAVHEIGHLLGLGHSSDLRAIMYPSI-P 281
Query: 300 SHQKNVQITDSDNLAIQKLY 319
+ V + D I+KLY
Sbjct: 282 PRTRKVNLAQDDIDGIRKLY 301
>MM26_HUMAN (Q9NRE1) Matrix metalloproteinase-26 precursor (EC
3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase)
Length = 261
Score = 81.3 bits (199), Expect = 4e-15
Identities = 70/251 (27%), Positives = 110/251 (42%), Gaps = 20/251 (7%)
Query: 79 YKGVDQIKQYLSDFGYLEQSGPFNNTLDQETVLALKTYQRYFNIQQDTLSEILQHIAL-- 136
+KG D ++ Y F ++ P L QET L + F+ L ++ H L
Sbjct: 26 HKGWDFVEGYFHQFFLTKKESPL---LTQETQTQLL---QQFHRNGTDLLDMQMHALLHQ 79
Query: 137 PRCGVPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALTQWS 196
P CGVPD +D S G + K T P + P + + A++ WS
Sbjct: 80 PHCGVPDG-------SDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWS 132
Query: 197 NTTRVLNFTETKSYDDANIKIGFYNITDDDGIN-DVAVGFTFIVLDSTNVKSGFITLDAT 255
N T ++ F + ++ DA+IK+ F+ +DG D G + G + D
Sbjct: 133 NVTPLI-FQQVQN-GDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKN 190
Query: 256 KYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAI 315
++W+ G++L A H+IGH LGL+HS + SIMYPT + Q++ D I
Sbjct: 191 EHWS--ASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRI 248
Query: 316 QKLYSSSTKAN 326
Q LY ++
Sbjct: 249 QHLYGEKCSSD 259
>MM12_MOUSE (P34960) Macrophage metalloelastase precursor (EC
3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12)
Length = 462
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/254 (28%), Positives = 112/254 (43%), Gaps = 21/254 (8%)
Query: 88 YLSDF-GYLEQSGPFNNTLDQETVLA--LKTYQRYFNI----QQDTLSEILQHIALPRCG 140
YLS F Y + P T L L+ Q++F + Q D + + HI PRCG
Sbjct: 29 YLSRFYDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHI--PRCG 86
Query: 141 VPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALTQWSNTTR 200
VPD + + + P+ ++W + Y + P K D+ +F+ A WS+ T
Sbjct: 87 VPD------VQHLRAVPQRSRWMKRYLTYRIYNYTPDMKRE-DVDYIFQKAFQVWSDVTP 139
Query: 201 VLNFTETKSYDDANIKIGF-YNITDDDGINDVAVGFTFIVLDSTNVKSGFITLDATKYWA 259
L F + D+A+I I F + D D G V G D + W
Sbjct: 140 -LRFRKLHK-DEADIMILFAFGAHGDFNYFDGKGGTLAHVFYPGPGIQGDAHFDEAETWT 197
Query: 260 LPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQKLY 319
+G +L A+H++GH LGL+HS++ KSIMYPT + +++ D IQ LY
Sbjct: 198 --KSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLY 255
Query: 320 SSSTKANANSDDSS 333
+ K + + SS
Sbjct: 256 GAPVKPPSLTKPSS 269
>MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 481
Score = 72.0 bits (175), Expect = 2e-12
Identities = 73/260 (28%), Positives = 108/260 (41%), Gaps = 23/260 (8%)
Query: 70 PSLPSQLPKYKGVD-QIKQYLSDFGYLEQSGPFNNTL----DQETVLALKTYQRYFNIQQ 124
PSLP+ P+ + ++ Q D Y ++ GP + TV +K Q +F ++
Sbjct: 22 PSLPAASPRTSRNNYRLAQAYLDKYYTKKGGPQIGEMVARGGNSTVKKIKELQEFFGLRV 81
Query: 125 DTLSE--ILQHIALPRCGVPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPL 182
+ + I PRCGVPD + Y L FP +W K T + P
Sbjct: 82 TGKLDRATMDVIKRPRCGVPD-VANYRL-----FPGEPKW-KKNTLTYRISKYTPSMTPA 134
Query: 183 DMTNVFRTALTQWSNTTRVLNFTETKSYDDANIKIGFYNITDDDGIN---DVAVGFTFIV 239
++ AL WS+ LNF + +A+I I F T D G + D G
Sbjct: 135 EVDRAMEMALRAWSSAVP-LNFVRINA-GEADIMISFE--TGDHGDSYPFDGPRGTLAHA 190
Query: 240 LDSTNVKSGFITLDATKYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILP 299
G D + W + T GF+L T A H+ GH LGL HS+D ++M+PT
Sbjct: 191 FAPGEGLGGDTHFDNAEKWTMGTN--GFNLFTVAAHEFGHALGLAHSTDPSALMFPTYKY 248
Query: 300 SHQKNVQITDSDNLAIQKLY 319
+ ++ D IQ LY
Sbjct: 249 QNPYGFRLPKDDVKGIQALY 268
>MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1
protease) (Uterine metalloproteinase) (Matrix
metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 71.2 bits (173), Expect = 4e-12
Identities = 72/248 (29%), Positives = 106/248 (42%), Gaps = 23/248 (9%)
Query: 83 DQIKQYLSDFGYLEQSGPFNNTLDQETVLALKTYQRYFNIQQD--TLSEILQHIALPRCG 140
+Q + YL F YL S T V L+ Q++F + + +++ + PRCG
Sbjct: 36 EQAQNYLRKF-YLHDSKTKKAT---SAVDKLREMQKFFGLPETGKLSPRVMEIMQKPRCG 91
Query: 141 VPDRILKYNLTNDISFPKGNQWFPKGT--KNLTYGFD-PRNKIPLDMTNVFRTALTQWSN 197
VPD + +++L P +W + + ++Y D PR + + + AL WS
Sbjct: 92 VPD-VAEFSL-----MPNSPKWHSRTVTYRIVSYTTDLPRFLVD----QIVKRALRMWSM 141
Query: 198 TTRVLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVK-SGFITLDATK 256
LNF S+ A+I IGF D G T + G D +
Sbjct: 142 QIP-LNFKRV-SWGTADIIIGFARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDE 199
Query: 257 YWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQ 316
YW E G + A H++GH LGL HSS S+MYPT H ++ +T D IQ
Sbjct: 200 YWT-DGEDSGVNFLFVATHELGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQ 258
Query: 317 KLYSSSTK 324
KLY K
Sbjct: 259 KLYGKRNK 266
>MM12_RAT (Q63341) Macrophage metalloelastase precursor (EC
3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12)
Length = 465
Score = 70.9 bits (172), Expect = 5e-12
Identities = 71/277 (25%), Positives = 113/277 (40%), Gaps = 23/277 (8%)
Query: 88 YLSDF-GYLEQSGPFNNTLDQETVLA--LKTYQRYFNI----QQDTLSEILQHIALPRCG 140
YLS F Y P T +L L+ Q++F + Q DT + + H + RCG
Sbjct: 32 YLSRFFDYQGDRIPMTKTKTNRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTS--RCG 89
Query: 141 VPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALTQWSNTTR 200
VPD + + + P+ ++W + Y + P K D+ +F+ A WS+ T
Sbjct: 90 VPD------VQHLRAVPQRSRWMKRYLTYRIYNYTPDMK-RADVDYIFQKAFQVWSDVTP 142
Query: 201 VLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVKSGFITLDATKYWAL 260
+ K D I F + D + ++ G D + W
Sbjct: 143 LRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQ-GDAHFDEAETWT- 200
Query: 261 PTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQKLYS 320
+G +L A+H++GH LGL HS++ KSIMYPT H +++ D +IQ LY
Sbjct: 201 -KSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYG 259
Query: 321 SSTK----ANANSDDSSGCFKLFGSSSSLLISLSIVF 353
+ K N S S+ C + + + I F
Sbjct: 260 APVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFF 296
>MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.34)
(Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase)
(PMNL-CL)
Length = 467
Score = 70.5 bits (171), Expect = 6e-12
Identities = 77/259 (29%), Positives = 107/259 (40%), Gaps = 32/259 (12%)
Query: 78 KYKGVDQIKQYLSDFGYLEQSGPFNNTLDQET---VLALKTYQRYF--NIQQDTLSEILQ 132
K K ++ YL F Y S + +T T V LK QR+F N+ E L
Sbjct: 26 KEKNTKTVQDYLEKF-YQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLD 84
Query: 133 HIALPRCGVPDRILKYNLTNDISFPKGNQWFPKGTK-NLTYGFDPRNKIP----LDMTNV 187
+ PRCGVPD + GN PK + NLTY RN P ++
Sbjct: 85 MMKKPRCGVPD-------SGGFMLTPGN---PKWERTNLTYRI--RNYTPQLSEAEVERA 132
Query: 188 FRTALTQWSNTTRVLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVKS 247
+ A WS + ++ FT S +A+I I FY D G N G I+ +
Sbjct: 133 IKDAFELWSVASPLI-FTRI-SQGEADINIAFYQ--RDHGDNSPFDGPNGILAHAFQPGQ 188
Query: 248 GF---ITLDATKYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKN 304
G DA + W + + ++L A H+ GH LGL HSSD ++MYP N
Sbjct: 189 GIGGDAHFDAEETWTNTSAN--YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSN 246
Query: 305 VQITDSDNLAIQKLYSSST 323
+ D IQ +Y S+
Sbjct: 247 YSLPQDDIDGIQAIYGLSS 265
>MM24_HUMAN (Q9Y5R2) Matrix metalloproteinase-24 precursor (EC
3.4.24.-) (MMP-24) (Membrane-type matrix
metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix
metalloproteinase) (MT5-MMP)
Length = 645
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/254 (27%), Positives = 103/254 (39%), Gaps = 29/254 (11%)
Query: 86 KQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCGV 141
+ +L +GYL + L L A+ T Q+++ I + + ++ + PRCGV
Sbjct: 82 QNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGV 141
Query: 142 PD--------RILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALT 193
PD R +Y LT G +W K + + P+ LD R A
Sbjct: 142 PDHPHLSRRRRNKRYALT-------GQKWRQKHITYSIHNYTPKVG-ELDTRKAIRQAFD 193
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W T L F E ++ +A+I I F + D D GF
Sbjct: 194 VWQKVTP-LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGI 252
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHSSD +IM P N
Sbjct: 253 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNF 312
Query: 306 QITDSDNLAIQKLY 319
++ D IQK+Y
Sbjct: 313 KLPQDDLQGIQKIY 326
>MM16_RAT (O35548) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 25/259 (9%)
Query: 85 IKQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCG 140
++ +L +GYL + P + L + AL Q+++ I + + + PRCG
Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
Query: 141 VPDRIL---KYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPL----DMTNVFRTALT 193
VPD+ K+N+ G +W K++TY +N P + R A
Sbjct: 103 VPDQTRGSSKFNIRRKRYALTGQKW---QHKHITYSI--KNVTPKVGDPETRRAIRRAFD 157
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W N T L F E + D +I I F + D D GF
Sbjct: 158 VWQNVTP-LTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGI 216
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHS+D +IM P N
Sbjct: 217 GGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF 276
Query: 306 QITDSDNLAIQKLYSSSTK 324
++ + D IQK+Y K
Sbjct: 277 KLPNDDLQGIQKIYGPPDK 295
>MM16_MOUSE (Q9WTR0) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 25/259 (9%)
Query: 85 IKQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCG 140
++ +L +GYL + P + L + AL Q+++ I + + + PRCG
Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
Query: 141 VPDRIL---KYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPL----DMTNVFRTALT 193
VPD+ K+N+ G +W K++TY +N P + R A
Sbjct: 103 VPDQTRGSSKFNIRRKRYALTGQKW---QHKHITYSI--KNVTPKVGDPETRRAIRRAFD 157
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W N T L F E + D +I I F + D D GF
Sbjct: 158 VWQNVTP-LTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGI 216
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHS+D +IM P N
Sbjct: 217 GGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF 276
Query: 306 QITDSDNLAIQKLYSSSTK 324
++ + D IQK+Y K
Sbjct: 277 KLPNDDLQGIQKIYGPPDK 295
>MM07_HUMAN (P09237) Matrilysin precursor (EC 3.4.24.23) (Pump-1
protease) (Uterine metalloproteinase) (Matrix
metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 69.3 bits (168), Expect = 1e-11
Identities = 64/246 (26%), Positives = 105/246 (42%), Gaps = 17/246 (6%)
Query: 83 DQIKQYLSDFGYLEQSGPFNNTLDQETVLALKTYQRYFNIQQDTL--SEILQHIALPRCG 140
+Q + YL F + N+L+ + LK Q++F + + S +++ + PRCG
Sbjct: 33 EQAQDYLKRFYLYDSETKNANSLEAK----LKEMQKFFGLPITGMLNSRVIEIMQKPRCG 88
Query: 141 VPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALTQWSNTTR 200
VPD + +Y+L FP +W K + R+ + + + AL W
Sbjct: 89 VPD-VAEYSL-----FPNSPKWTSKVVTYRIVSYT-RDLPHITVDRLVSKALNMWGKEIP 141
Query: 201 VLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVK-SGFITLDATKYWA 259
L+F + + A+I IGF D G T + G D + W
Sbjct: 142 -LHFRKVV-WGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWT 199
Query: 260 LPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQKLY 319
G + AA H++GH LG+ HSSD ++MYPT +N +++ D IQKLY
Sbjct: 200 -DGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLY 258
Query: 320 SSSTKA 325
+ +
Sbjct: 259 GKRSNS 264
>MM16_HUMAN (P51512) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP) (MMP-X2)
Length = 607
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/259 (27%), Positives = 106/259 (40%), Gaps = 25/259 (9%)
Query: 85 IKQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCG 140
++ +L +GYL + P + L + AL Q+++ I + + + PRCG
Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
Query: 141 VPDRIL---KYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPL----DMTNVFRTALT 193
VPD+ K+++ G +W K++TY +N P + R A
Sbjct: 103 VPDQTRGSSKFHIRRKRYALTGQKW---QHKHITYSI--KNVTPKVGDPETRKAIRRAFD 157
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W N T L F E + D +I I F + D D GF
Sbjct: 158 VWQNVTP-LTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGI 216
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHS+D +IM P N
Sbjct: 217 GGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF 276
Query: 306 QITDSDNLAIQKLYSSSTK 324
++ + D IQK+Y K
Sbjct: 277 KLPNDDLQGIQKIYGPPDK 295
>MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13)
Length = 472
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/244 (28%), Positives = 108/244 (43%), Gaps = 27/244 (11%)
Query: 86 KQYLSDFGY-LEQSGPFNNTLDQETVLALKTYQRYFNIQ-----QDTLSEILQHIALPRC 139
++YL + Y L +G T V L+ Q +F ++ D +I++ PRC
Sbjct: 41 ERYLKSYYYPLNPAGILKKTAANSVVDRLREMQSFFGLEVTGKLDDNTLDIMKK---PRC 97
Query: 140 GVPDRILKYNLTNDISFPKGNQWFPKGTKNLTY---GFDPRNKIPLDMTNVFRTALTQWS 196
GVPD + +YN+ FP+ +W PK NLTY + P + ++ F+ A WS
Sbjct: 98 GVPD-VGEYNV-----FPRTLKW-PK--MNLTYRIVNYTP-DLTHSEVEKAFKKAFKVWS 147
Query: 197 NTTRVLNFTETKSYDDANIKIGFYNITDDDGIN-DVAVGFTFIVLDSTNVKSGFITLDAT 255
+ T LNFT + A+I I F D D G G D
Sbjct: 148 DVTP-LNFTRLYN-GTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDD 205
Query: 256 KYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAI 315
+ W + +G++L A H+ GH LGL+HS D ++M+P + + + + D D I
Sbjct: 206 ETWT--SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFVLPDDDVQGI 263
Query: 316 QKLY 319
Q LY
Sbjct: 264 QYLY 267
>MM13_BOVIN (O77656) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13)
Length = 471
Score = 68.6 bits (166), Expect = 2e-11
Identities = 67/244 (27%), Positives = 105/244 (42%), Gaps = 27/244 (11%)
Query: 86 KQYLSDFGYLEQ-SGPFNNTLDQETVLALKTYQRYFNIQ-----QDTLSEILQHIALPRC 139
+ YL + Y + +G T + L+ Q +F ++ D +I++ PRC
Sbjct: 40 ESYLKSYYYPQNPAGILKKTAASSVIDRLREMQSFFGLEVTGRLDDNTLDIMKK---PRC 96
Query: 140 GVPDRILKYNLTNDISFPKGNQWFPKGTKNLTY---GFDPRNKIPLDMTNVFRTALTQWS 196
GVPD + +YN+ FP+ +W NLTY + P + ++ FR A WS
Sbjct: 97 GVPD-VGEYNV-----FPRTLKW---SKMNLTYRIVNYTP-DLTHSEVEKAFRKAFKVWS 146
Query: 197 NTTRVLNFTETKSYDDANIKIGFYNITDDDGIN-DVAVGFTFIVLDSTNVKSGFITLDAT 255
+ T LNFT + A+I I F D D G G D
Sbjct: 147 DVTP-LNFTRIHN-GTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDD 204
Query: 256 KYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAI 315
+ W + +G++L A H+ GH LGL+HS D ++M+P + + + + D D I
Sbjct: 205 ETWT--SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGI 262
Query: 316 QKLY 319
Q LY
Sbjct: 263 QSLY 266
>HE_HEMPU (P91953) Hatching enzyme precursor (EC 3.4.24.12) (HE)
(HEZ) (Envelysin) (Sea-urchin-hatching proteinase)
Length = 591
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/247 (28%), Positives = 106/247 (42%), Gaps = 22/247 (8%)
Query: 82 VDQIKQYLSDFGYLEQSGPFNNTLDQETVLALKTYQRYFNIQQDTL--SEILQHIALPRC 139
V ++K L FGY+ F T L+ YQ+ I Q + +E + PRC
Sbjct: 104 VVKLKANLEQFGYVPLGSTFGEANINYTSAILE-YQQNGGINQTGILDAETAALLDTPRC 162
Query: 140 GVPDRILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMT---NVFRTALTQWS 196
GVPD IL Y +T I++P+ +TY F + L T N R A W
Sbjct: 163 GVPD-ILPY-VTGGIAWPRNVA--------VTYSFGTLSN-DLSQTAIKNELRRAFQVWD 211
Query: 197 NTTRVLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVKSGFITLDATK 256
+ + L F E +I+I F + DGI+ G ++ + ++G D ++
Sbjct: 212 DVSS-LTFREVVDSSSVDIRIKFGSYEHGDGISFDGQGG--VLAHAFLPRNGDAHFDDSE 268
Query: 257 YWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQ 316
W + T + G +L A H+ GH LGL HS ++MYP + N + D I
Sbjct: 269 RWTIGT-NSGTNLFQVAAHEFGHSLGLYHSDVQSALMYP-YYRGYNPNFNLDRDDIAGIT 326
Query: 317 KLYSSST 323
LY +T
Sbjct: 327 SLYGRNT 333
>MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 482
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/267 (28%), Positives = 113/267 (41%), Gaps = 37/267 (13%)
Query: 70 PSLPSQLPK-YKGVDQIKQYLSDFGYLEQSGPFNNTL----DQETVLALKTYQRYFNIQ- 123
P+L + P+ ++ + Q D Y ++ GP + + +K Q +F ++
Sbjct: 23 PNLLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNPMIRRIKELQIFFGLKV 82
Query: 124 -----QDTLSEILQHIALPRCGVPDRILKYNLTNDISFPKGNQWFPKGTKN-LTYGFDPR 177
Q+T++ I + PRCGVPD + Y L FP +W KN LTY
Sbjct: 83 TGKLDQNTMNVIKK----PRCGVPD-VANYRL-----FPGEPKW----KKNILTYRISKY 128
Query: 178 --NKIPLDMTNVFRTALTQWSNTTRVLNFTETKSYDDANIKIGFYNITDDDGIN---DVA 232
+ P ++ + AL WS T LNF S +A+I I F T D G + D
Sbjct: 129 TPSMSPTEVDKAIQMALHAWS-TAVPLNFVRINS-GEADIMISFE--TGDHGDSYPFDGP 184
Query: 233 VGFTFIVLDSTNVKSGFITLDATKYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSI 292
G G D + W + T GF+L T A H+ GH LGL HS+D ++
Sbjct: 185 RGTLAHAFAPGEGLGGDTHFDNAEKWTMGTN--GFNLFTVAAHEFGHALGLGHSTDPSAL 242
Query: 293 MYPTILPSHQKNVQITDSDNLAIQKLY 319
MYPT + + D IQ LY
Sbjct: 243 MYPTYKYQNPYRFHLPKDDVKGIQALY 269
>MM24_RAT (Q99PW6) Matrix metalloproteinase-24 precursor (EC
3.4.24.-) (MMP-24) (Membrane-type matrix
metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix
metalloproteinase) (MT5-MMP)
Length = 618
Score = 67.8 bits (164), Expect = 4e-11
Identities = 70/254 (27%), Positives = 103/254 (39%), Gaps = 29/254 (11%)
Query: 86 KQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCGV 141
+ +L +GYL + L L A+ T Q+++ I + + ++ + PRCGV
Sbjct: 55 QNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGV 114
Query: 142 PD--------RILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALT 193
PD R +Y LT G +W K + + P+ LD R A
Sbjct: 115 PDHPHLSRRRRNKRYALT-------GQKWRQKHITYSIHNYTPKVG-ELDTRKAIRQAFD 166
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W T L F E ++ +A+I I F + D D GF
Sbjct: 167 VWQKVTP-LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGI 225
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHS+D +IM P N
Sbjct: 226 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNF 285
Query: 306 QITDSDNLAIQKLY 319
++ D IQK+Y
Sbjct: 286 KLPQDDLQGIQKIY 299
>MM24_MOUSE (Q9R0S2) Matrix metalloproteinase-24 precursor (EC
3.4.24.-) (MMP-24) (Membrane-type matrix
metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix
metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 67.8 bits (164), Expect = 4e-11
Identities = 70/254 (27%), Positives = 103/254 (39%), Gaps = 29/254 (11%)
Query: 86 KQYLSDFGYLEQSGPFNNTLDQETVL--ALKTYQRYFNIQQDTLSE--ILQHIALPRCGV 141
+ +L +GYL + L L A+ T Q+++ I + + ++ + PRCGV
Sbjct: 55 QNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGV 114
Query: 142 PD--------RILKYNLTNDISFPKGNQWFPKGTKNLTYGFDPRNKIPLDMTNVFRTALT 193
PD R +Y LT G +W K + + P+ LD R A
Sbjct: 115 PDHPHLSRRRRNKRYALT-------GQKWRQKHITYSIHNYTPKVG-ELDTRKAIRQAFD 166
Query: 194 QWSNTTRVLNFTETKSYD------DANIKIGFYN-ITDDDGINDVAVGFTFIVLDSTNVK 246
W T L F E ++ +A+I I F + D D GF
Sbjct: 167 VWQKVTP-LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGI 225
Query: 247 SGFITLDATKYWALPT-EHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNV 305
G D+ + W L H G DL A+H++GH LGLEHS+D +IM P N
Sbjct: 226 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNF 285
Query: 306 QITDSDNLAIQKLY 319
++ D IQK+Y
Sbjct: 286 KLPQDDLQGIQKIY 299
>MM13_XENLA (Q10835) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13) (Fragment)
Length = 469
Score = 67.4 bits (163), Expect = 5e-11
Identities = 65/222 (29%), Positives = 100/222 (44%), Gaps = 28/222 (12%)
Query: 113 LKTYQRYFNIQ------QDTLSEILQHIALPRCGVPDRILKYNLTNDISFPKGNQWFPKG 166
LK Q +F ++ +DTL + Q PRCGVPD + +YN FP+ +W P+
Sbjct: 66 LKEMQSFFGLEVTGKLNEDTLDIMKQ----PRCGVPD-VGQYNF-----FPRKLKW-PRN 114
Query: 167 TKNLTY---GFDPRNKIPLDMTNVFRTALTQWSNTTRVLNFTETKSYDDANIKIGFYNIT 223
NLTY + P + ++ + AL WS+ T LNFT ++ A+I + F
Sbjct: 115 --NLTYRIVNYTP-DLSTSEVDRAIKKALKVWSDVTP-LNFTRLRT-GTADIMVSFGKKE 169
Query: 224 DDDGIN-DVAVGFTFIVLDSTNVKSGFITLDATKYWALPTEHRGFDLETAAMHQIGHLLG 282
D D G G D + ++ T+++G++L A H+ GH LG
Sbjct: 170 HGDYYPFDGPDGLLAHAFPPGEKLGGDTHFDDDEMFS--TDNKGYNLFVVAAHEFGHALG 227
Query: 283 LEHSSDNKSIMYPTILPSHQKNVQITDSDNLAIQKLYSSSTK 324
L+HS D S+M+P + + D D IQ LY +
Sbjct: 228 LDHSRDPGSLMFPVYTYTETSRFVLPDDDVQGIQVLYGPGNR 269
>MM07_MOUSE (Q10738) Matrilysin precursor (EC 3.4.24.23) (Pump-1
protease) (Uterine metalloproteinase) (Matrix
metalloproteinase-7) (MMP-7) (Matrin)
Length = 264
Score = 67.0 bits (162), Expect = 7e-11
Identities = 72/244 (29%), Positives = 109/244 (44%), Gaps = 25/244 (10%)
Query: 83 DQIKQYLSDF-GYLEQSGPFNNTLDQETVLALKTYQRYFNIQQD-TLSE-ILQHIALPRC 139
+Q + YL F + ++ N+ +D LK Q++F + LS I++ + PRC
Sbjct: 33 EQAQNYLRKFYPHDSKTKKVNSLVDN-----LKEMQKFFGLPMTGKLSPYIMEIMQKPRC 87
Query: 140 GVPDRILKYNLTNDISFPKGNQWFPKGT--KNLTYGFD-PRNKIPLDMTNVFRTALTQWS 196
GVPD + +Y+L P +W + + ++Y D PR + + + + AL WS
Sbjct: 88 GVPD-VAEYSL-----MPNSPKWHSRIVTYRIVSYTSDLPR----IVVDQIVKKALRMWS 137
Query: 197 NTTRVLNFTETKSYDDANIKIGFYNITDDDGINDVAVGFTFIVLDSTNVK-SGFITLDAT 255
LNF S+ A+I IGF D G T + G D
Sbjct: 138 MQIP-LNFKRV-SWGTADIIIGFARRDHGDSFPFDGPGNTLGHAFAPGPGLGGDAHFDKD 195
Query: 256 KYWALPTEHRGFDLETAAMHQIGHLLGLEHSSDNKSIMYPTILPSHQKNVQITDSDNLAI 315
+YW E G + AA H+ GH LGL HSS ++MYPT + ++ +T D I
Sbjct: 196 EYWT-DGEDAGVNFLFAATHEFGHSLGLSHSSVPGTVMYPTYQRDYSEDFSLTKDDIAGI 254
Query: 316 QKLY 319
QKLY
Sbjct: 255 QKLY 258
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,290,727
Number of Sequences: 164201
Number of extensions: 1786863
Number of successful extensions: 5156
Number of sequences better than 10.0: 112
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 4989
Number of HSP's gapped (non-prelim): 138
length of query: 360
length of database: 59,974,054
effective HSP length: 111
effective length of query: 249
effective length of database: 41,747,743
effective search space: 10395188007
effective search space used: 10395188007
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Medicago: description of AC144345.6