BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144345.3 + phase: 0
(368 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24... 306 4e-83
HE_HEMPU (P91953) Hatching enzyme precursor (EC 3.4.24.12) (HE) ... 154 3e-37
MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC 3.... 149 1e-35
MM20_HUMAN (O60882) Matrix metalloproteinase-20 precursor (EC 3.... 147 3e-35
HE_PARLI (P22757) Hatching enzyme precursor (EC 3.4.24.12) (HE) ... 146 7e-35
MM20_PIG (P79287) Matrix metalloproteinase-20 precursor (EC 3.4.... 145 1e-34
MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC 3.... 144 4e-34
MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1 pr... 131 3e-30
MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.... 130 4e-30
MM01_PIG (P21692) Interstitial collagenase precursor (EC 3.4.24.... 130 4e-30
MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix... 129 1e-29
MM18_XENLA (O13065) Matrix metalloproteinase-18 precursor (EC 3.... 126 1e-28
MM16_HUMAN (P51512) Matrix metalloproteinase-16 precursor (EC 3.... 126 1e-28
MM12_RABIT (P79227) Macrophage metalloelastase precursor (EC 3.4... 125 1e-28
MM08_RAT (O88766) Neutrophil collagenase precursor (EC 3.4.24.34... 125 2e-28
MM16_RAT (O35548) Matrix metalloproteinase-16 precursor (EC 3.4.... 125 2e-28
MM16_MOUSE (Q9WTR0) Matrix metalloproteinase-16 precursor (EC 3.... 125 2e-28
MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 124 3e-28
MM01_HUMAN (P03956) Interstitial collagenase precursor (EC 3.4.2... 124 4e-28
MM01_HORSE (Q9XSZ5) Interstitial collagenase precursor (EC 3.4.2... 124 4e-28
>MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24.-)
(SMEP1)
Length = 305
Score = 306 bits (785), Expect = 4e-83
Identities = 157/287 (54%), Positives = 193/287 (66%), Gaps = 15/287 (5%)
Query: 46 PGAWDG---YKNFTGCSRGKTYDGLSKLKNYFNHFGYIPNGPPSNFTDDFDEALESAVRT 102
P AWDG YK FT G+ Y GLS +KNYF+H GYIPN P +F D+FD+ L SA++T
Sbjct: 31 PYAWDGEATYK-FTTYHPGQNYKGLSNVKNYFHHLGYIPNAP--HFDDNFDDTLVSAIKT 87
Query: 103 YQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFP 162
YQKN+NLN+TG+ D T+ I+ PRCGV DII T + +T+F ++ Y+FF
Sbjct: 88 YQKNYNLNVTGKFDINTLKQIMTPRCGVPDIIINT---------NKTTSFGMISDYTFFK 138
Query: 163 GQPRWPEGTQTLTYAFDPSENLDDATKQVFANAFNQWSKVTTITFTEATSYSSSDIKIGF 222
PRW GT LTYAF P LDD K A AF++W+ V I F E TSY +++IKI F
Sbjct: 139 DMPRWQAGTTQLTYAFSPEPRLDDTFKSAIARAFSKWTPVVNIAFQETTSYETANIKILF 198
Query: 223 YSGDHGDGEAFDGVLGTLAHAFSPTDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVH 282
S +HGD FDG G L HAF+PTDGR H D E WV +GDVT+S +++A DLESV VH
Sbjct: 199 ASKNHGDPYPFDGPGGILGHAFAPTDGRCHFDADEYWVASGDVTKSPVTSAFDLESVAVH 258
Query: 283 EIGHLLGLGHSSIEEAIMYPTISSRTKKVELESDDIEGIQMLYGSNP 329
EIGHLLGLGHSS AIMYP+I RT+KV L DDI+GI+ LYG NP
Sbjct: 259 EIGHLLGLGHSSDLRAIMYPSIPPRTRKVNLAQDDIDGIRKLYGINP 305
>HE_HEMPU (P91953) Hatching enzyme precursor (EC 3.4.24.12) (HE)
(HEZ) (Envelysin) (Sea-urchin-hatching proteinase)
Length = 591
Score = 154 bits (389), Expect = 3e-37
Identities = 103/277 (37%), Positives = 129/277 (46%), Gaps = 46/277 (16%)
Query: 69 KLKNYFNHFGYIPNGPPSNFTDDFDEA---LESAVRTYQKNFNLNITGELDDATMNYIVK 125
KLK FGY+P G F EA SA+ YQ+N +N TG LD T +
Sbjct: 106 KLKANLEQFGYVPLG------STFGEANINYTSAILEYQQNGGINQTGILDAETAALLDT 159
Query: 126 PRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSEN-- 183
PRCGV DI+ T G WP +TY+F N
Sbjct: 160 PRCGVPDILPYVT------------------------GGIAWPRNV-AVTYSFGTLSNDL 194
Query: 184 LDDATKQVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHA 243
A K AF W V+++TF E SS DI+I F S +HGDG +FDG G LAHA
Sbjct: 195 SQTAIKNELRRAFQVWDDVSSLTFREVVDSSSVDIRIKFGSYEHGDGISFDGQGGVLAHA 254
Query: 244 FSPTDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPT 303
F P +G H D +E W + ++ +L V HE GH LGL HS ++ A+MYP
Sbjct: 255 FLPRNGDAHFDDSERWTI-------GTNSGTNLFQVAAHEFGHSLGLYHSDVQSALMYPY 307
Query: 304 ISSRTKKVELESDDIEGIQMLYGSNPNFTGTTTATSR 340
L+ DDI GI LYG N TG+TT T+R
Sbjct: 308 YRGYNPNFNLDRDDIAGITSLYGRN---TGSTTTTTR 341
>MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 482
Score = 149 bits (375), Expect = 1e-35
Identities = 91/242 (37%), Positives = 120/242 (48%), Gaps = 37/242 (15%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q F L +TG+LD TMN I KPRCGV D VA+Y
Sbjct: 71 IKELQIFFGLKVTGKLDQNTMNVIKKPRCGVPD----------------------VANYR 108
Query: 160 FFPGQPRWPEGTQTLTYA-FDPSENLDDATKQVFANAFNQWSKVTTITFTEATSYSSSDI 218
FPG+P+W + T + + PS + + K + A + WS + F S +DI
Sbjct: 109 LFPGEPKWKKNILTYRISKYTPSMSPTEVDKAI-QMALHAWSTAVPLNFVRINS-GEADI 166
Query: 219 KIGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTESSLSNAVD 275
I F +GDHGD FDG GTLAHAF+P + G H D AE W + +N +
Sbjct: 167 MISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG--------TNGFN 218
Query: 276 LESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTK-KVELESDDIEGIQMLYGSNPNFTGT 334
L +V HE GH LGLGHS+ A+MYPT + + L DD++GIQ LYG F G
Sbjct: 219 LFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPYRFHLPKDDVKGIQALYGPRKIFPGK 278
Query: 335 TT 336
T
Sbjct: 279 PT 280
>MM20_HUMAN (O60882) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 483
Score = 147 bits (372), Expect = 3e-35
Identities = 91/242 (37%), Positives = 118/242 (48%), Gaps = 37/242 (15%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q F L +TG+LD TMN I KPRCGV D VA+Y
Sbjct: 72 IKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPD----------------------VANYR 109
Query: 160 FFPGQPRWPEGTQTLTYA-FDPSENLDDATKQVFANAFNQWSKVTTITFTEATSYSSSDI 218
FPG+P+W + T T + + PS + + K V A WS ++F S +DI
Sbjct: 110 LFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAV-EMALQAWSSAVPLSFVRINS-GEADI 167
Query: 219 KIGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTESSLSNAVD 275
I F +GDHGD FDG GTLAHAF+P + G H D E W + +N +
Sbjct: 168 MISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNPEKWTMG--------TNGFN 219
Query: 276 LESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTK-KVELESDDIEGIQMLYGSNPNFTGT 334
L +V HE GH LGL HS+ A+MYPT + L DD++GIQ LYG F G
Sbjct: 220 LFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGK 279
Query: 335 TT 336
T
Sbjct: 280 PT 281
>HE_PARLI (P22757) Hatching enzyme precursor (EC 3.4.24.12) (HE)
(HEZ) (Envelysin) (Sea-urchin-hatching proteinase)
Length = 587
Score = 146 bits (369), Expect = 7e-35
Identities = 101/276 (36%), Positives = 132/276 (47%), Gaps = 44/276 (15%)
Query: 70 LKNYFNHFGYIPNGPPSNFTDDFDEA---LESAVRTYQKNFNLNITGELDDATMNYIVKP 126
LK + FGY P G F EA SA+ +Q++ +N TG LD T + P
Sbjct: 104 LKAHLEKFGYTPPG------STFGEANLNYTSAILDFQEHGGINQTGILDADTAELLSTP 157
Query: 127 RCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDP--SENL 184
RCGV D++ TS + N Q +TY+F S+
Sbjct: 158 RCGVPDVLPFVTSSITWSRN-------------------------QPVTYSFGALTSDLN 192
Query: 185 DDATKQVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAF 244
+ K AF W V+ ++F E +S DI+I F S DHGDG +FDG G LAHAF
Sbjct: 193 QNDVKDEIRRAFRVWDDVSGLSFREVPDTTSVDIRIKFGSYDHGDGISFDGRGGVLAHAF 252
Query: 245 SPTDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTI 304
P +G H D +E W TE + S +L V HE GH LGL HS++ A+MYP
Sbjct: 253 LPRNGDAHFDDSETW------TEGTRS-GTNLFQVAAHEFGHSLGLYHSTVRSALMYPYY 305
Query: 305 SSRTKKVELESDDIEGIQMLYGSNPNFTGTTTATSR 340
L++DDI GI+ LYGSN +GTTT T R
Sbjct: 306 QGYVPNFRLDNDDIAGIRSLYGSNSG-SGTTTTTRR 340
>MM20_PIG (P79287) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 483
Score = 145 bits (367), Expect = 1e-34
Identities = 89/242 (36%), Positives = 118/242 (47%), Gaps = 37/242 (15%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q F L +TG+LD TM+ I +PRCGV D VA+Y
Sbjct: 72 IKELQAFFGLRVTGKLDRTTMDVIKRPRCGVPD----------------------VANYR 109
Query: 160 FFPGQPRWPEGTQTLTYA-FDPSENLDDATKQVFANAFNQWSKVTTITFTEATSYSSSDI 218
FPG+P+W + T T + + PS + K + A WS ++F + +DI
Sbjct: 110 LFPGEPKWKKNTLTYRISKYTPSMTPAEVDKAM-EMALQAWSSAVPLSFVRVNA-GEADI 167
Query: 219 KIGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTESSLSNAVD 275
I F +GDHGD FDG GTLAHAF+P + G H D AE W + N +
Sbjct: 168 MISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG--------MNGFN 219
Query: 276 LESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTK-KVELESDDIEGIQMLYGSNPNFTGT 334
L +V HE GH LGL HS+ A+MYPT + L DD++GIQ LYG FTG
Sbjct: 220 LFTVAAHEFGHALGLAHSTDPSALMYPTYKYQNPYGFHLPKDDVKGIQALYGPRKTFTGK 279
Query: 335 TT 336
T
Sbjct: 280 PT 281
>MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 481
Score = 144 bits (363), Expect = 4e-34
Identities = 86/242 (35%), Positives = 116/242 (47%), Gaps = 35/242 (14%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q+ F L +TG+LD ATM+ I +PRCGV D VA+Y
Sbjct: 70 IKELQEFFGLRVTGKLDRATMDVIKRPRCGVPD----------------------VANYR 107
Query: 160 FFPGQPRWPEGTQTLTYAFDPSENLDDATKQVFANAFNQWSKVTTITFTEATSYSSSDIK 219
FPG+P+W + T T + + A WS + F + +DI
Sbjct: 108 LFPGEPKWKKNTLTYRISKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINA-GEADIM 166
Query: 220 IGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTESSLSNAVDL 276
I F +GDHGD FDG GTLAHAF+P + G H D AE W + +N +L
Sbjct: 167 ISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG--------TNGFNL 218
Query: 277 ESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTK-KVELESDDIEGIQMLYGSNPNFTGTT 335
+V HE GH LGL HS+ A+M+PT + L DD++GIQ LYG F+G
Sbjct: 219 FTVAAHEFGHALGLAHSTDPSALMFPTYKYQNPYGFRLPKDDVKGIQALYGPRRAFSGKP 278
Query: 336 TA 337
TA
Sbjct: 279 TA 280
>MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1
protease) (Uterine metalloproteinase) (Matrix
metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 131 bits (329), Expect = 3e-30
Identities = 93/263 (35%), Positives = 119/263 (44%), Gaps = 46/263 (17%)
Query: 71 KNYFNHFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCGV 130
+NY F Y+ + T D+ +R QK F L TG+L M + KPRCGV
Sbjct: 39 QNYLRKF-YLHDSKTKKATSAVDK-----LREMQKFFGLPETGKLSPRVMEIMQKPRCGV 92
Query: 131 ADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQT---LTYAFDPSENLDDA 187
D VA +S P P+W T T ++Y D L D
Sbjct: 93 PD----------------------VAEFSLMPNSPKWHSRTVTYRIVSYTTDLPRFLVD- 129
Query: 188 TKQVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP- 246
Q+ A WS + F + S+ ++DI IGF GDHGD FDG TL HAF+P
Sbjct: 130 --QIVKRALRMWSMQIPLNF-KRVSWGTADIIIGFARGDHGDNFPFDGPGNTLGHAFAPG 186
Query: 247 --TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTI 304
G H DK E W D + V+ V HE+GH LGLGHSS+ ++MYPT
Sbjct: 187 PGLGGDAHFDKDEYWTDGED-------SGVNFLFVATHELGHSLGLGHSSVPSSVMYPTY 239
Query: 305 -SSRTKKVELESDDIEGIQMLYG 326
++ L DDI GIQ LYG
Sbjct: 240 QGDHSEDFSLTKDDIAGIQKLYG 262
>MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.34)
(Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase)
(PMNL-CL)
Length = 467
Score = 130 bits (328), Expect = 4e-30
Identities = 92/284 (32%), Positives = 129/284 (45%), Gaps = 38/284 (13%)
Query: 70 LKNYFNHFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCG 129
+++Y F +P+ + + + ++ Q+ F LN+TG+ ++ T++ + KPRCG
Sbjct: 33 VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92
Query: 130 VADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENLDDATK 189
V D SG F + PG P+W T + + +
Sbjct: 93 VPD---------SGGFMLT-------------PGNPKWERTNLTYRIRNYTPQLSEAEVE 130
Query: 190 QVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP--- 246
+ +AF WS + + FT S +DI I FY DHGD FDG G LAHAF P
Sbjct: 131 RAIKDAFELWSVASPLIFTRI-SQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQG 189
Query: 247 TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISS 306
G H D E W ++ S +L V HE GH LGL HSS A+MYP +
Sbjct: 190 IGGDAHFDAEETW--------TNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAF 241
Query: 307 R-TKKVELESDDIEGIQMLYG--SNP-NFTGTTTATSRDRDSSF 346
R T L DDI+GIQ +YG SNP TG +T D +F
Sbjct: 242 RETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTF 285
>MM01_PIG (P21692) Interstitial collagenase precursor (EC 3.4.24.7)
(Matrix metalloproteinase-1) (MMP-1)
Length = 469
Score = 130 bits (328), Expect = 4e-30
Identities = 96/267 (35%), Positives = 127/267 (46%), Gaps = 45/267 (16%)
Query: 70 LKNYFNHFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCG 129
LKNY+N +G P + +E ++ Q+ F L +TG+ D T+N + +PRCG
Sbjct: 38 LKNYYN---LNSDGVPVEKKRNSGLVVEK-LKQMQQFFGLKVTGKPDAETLNVMKQPRCG 93
Query: 130 VADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFD---PSENLDD 186
V D VA + PG PRW E T LTY + P + +D
Sbjct: 94 VPD----------------------VAEFVLTPGNPRW-ENTH-LTYRIENYTPDLSRED 129
Query: 187 ATKQVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP 246
+ + AF WS V+ +TFT+ S +DI I F GDH D FDG G LAHAF P
Sbjct: 130 VDRAI-EKAFQLWSNVSPLTFTKV-SEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQP 187
Query: 247 ---TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPT 303
G H D+ E W N +L V HE+GH LGL HS+ A+MYP
Sbjct: 188 GPGIGGDAHFDEDERWTKN--------FRDYNLYRVAAHELGHSLGLSHSTDIGALMYPN 239
Query: 304 ISSRTKKVELESDDIEGIQMLYGSNPN 330
T V+L DDI+GIQ +YG + N
Sbjct: 240 Y-IYTGDVQLSQDDIDGIQAIYGPSEN 265
>MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
(Transformation-associated protein 34A)
Length = 476
Score = 129 bits (324), Expect = 1e-29
Identities = 86/244 (35%), Positives = 119/244 (48%), Gaps = 44/244 (18%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
+ QK L +TG+LD T+ + KPRCGV D V +S
Sbjct: 64 IEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPD----------------------VGGFS 101
Query: 160 FFPGQPRWPEGT---QTLTYAFD-PSENLDDATKQVFANAFNQWSKVTTITFTEATSYSS 215
FPG P+W + + + Y D P E++D A ++ A W +VT +TF+ S
Sbjct: 102 TFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIER----ALKVWEEVTPLTFSRI-SEGE 156
Query: 216 SDIKIGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTESSLSN 272
+DI I F G+HGD FDGV +LAHA+ P G H D E W + +
Sbjct: 157 ADIMISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSLG--------PS 208
Query: 273 AVDLESVVVHEIGHLLGLGHSSIEEAIMYPT--ISSRTKKVELESDDIEGIQMLYGSNPN 330
+L V HE+GH LGL HS+ +E++MYP S+ + L DDIEGIQ LYG+ P+
Sbjct: 209 GTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPS 268
Query: 331 FTGT 334
T
Sbjct: 269 SDAT 272
>MM18_XENLA (O13065) Matrix metalloproteinase-18 precursor (EC
3.4.24.-) (MMP-18) (Collagenase-4) (Collagenase 4)
(xCol4)
Length = 467
Score = 126 bits (316), Expect = 1e-28
Identities = 95/262 (36%), Positives = 121/262 (45%), Gaps = 42/262 (16%)
Query: 92 FDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTN 151
F E LE QK F L +TG LD T+ + KPRCGV D+ +T S +
Sbjct: 60 FTEKLEQM----QKFFGLKVTGTLDPKTVEVMEKPRCGVYDVGQYSTVAKSSAWQKKDLT 115
Query: 152 FHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENLDDATKQVFANAFNQWSKVTTITFTEAT 211
+ + +F P P+ T AF WS VT +TFT
Sbjct: 116 YRIL---NFTPDLPQADVET-------------------AIQRAFKVWSDVTPLTFTRIY 153
Query: 212 SYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSPTD---GRLHLDKAEDWVVNGDVTES 268
+ SDI+I F +GDH D FDG G LAHAF P + G H D+ E W +
Sbjct: 154 N-EVSDIEISFTAGDHKDNSPFDGSGGILAHAFQPGNGIGGDAHFDEDETW--------T 204
Query: 269 SLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTKKV-ELESDDIEGIQMLYG- 326
S +L V HE GH LGL HS+ + A+MYPT S+ K +L DDI IQ LYG
Sbjct: 205 KTSEIYNLFLVAAHEFGHSLGLSHSTDQGALMYPTYSNTDPKTFQLPQDDINAIQYLYGK 264
Query: 327 -SNP-NFTGTTTATSRDRDSSF 346
SNP TG +T + D + F
Sbjct: 265 SSNPVQPTGPSTPSRCDPNVVF 286
>MM16_HUMAN (P51512) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP) (MMP-X2)
Length = 607
Score = 126 bits (316), Expect = 1e-28
Identities = 90/272 (33%), Positives = 125/272 (45%), Gaps = 34/272 (12%)
Query: 71 KNYFN------HFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIV 124
+ YFN +GY+P P E ++SA+ Q+ + +N+TG++D T++++
Sbjct: 38 EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97
Query: 125 KPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENL 184
KPRCGV D G S+ FH GQ +W T + +
Sbjct: 98 KPRCGVPDQTRG------------SSKFHIRRKRYALTGQ-KWQHKHITYSIKNVTPKVG 144
Query: 185 DDATKQVFANAFNQWSKVTTITFTEA------TSYSSSDIKIGFYSGDHGDGEAFDGVLG 238
D T++ AF+ W VT +TF E DI I F SG HGD FDG G
Sbjct: 145 DPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGG 204
Query: 239 TLAHAFSP---TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSI 295
LAHA+ P G H D E W + + + DL V VHE+GH LGL HS+
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGN-----DLFLVAVHELGHALGLEHSND 259
Query: 296 EEAIMYPTIS-SRTKKVELESDDIEGIQMLYG 326
AIM P T +L +DD++GIQ +YG
Sbjct: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291
>MM12_RABIT (P79227) Macrophage metalloelastase precursor (EC
3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12)
Length = 464
Score = 125 bits (315), Expect = 1e-28
Identities = 87/238 (36%), Positives = 114/238 (47%), Gaps = 41/238 (17%)
Query: 96 LESAVRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTV 155
+E V+ Q+ LN+TG+LD +T+ + KPRCGV D V
Sbjct: 55 IEEKVQEMQQFLGLNVTGQLDTSTLEMMHKPRCGVPD----------------------V 92
Query: 156 AHYSFFPGQPRWPEGTQTLTYA---FDPSENLDDATKQVFANAFNQWSKVTTITFTEATS 212
H+ PG+P W + +TY + P +D + AF WS VT + F + T+
Sbjct: 93 YHFKTMPGRPVWRK--HYITYRIKNYTPDMKRED-VEYAIQKAFQVWSDVTPLKFRKITT 149
Query: 213 YSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP---TDGRLHLDKAEDWVVNGDVTESS 269
+DI I F SG HGD AFDG G +AHAF P G H D+ E W S
Sbjct: 150 -GKADIMILFASGAHGDYGAFDGRGGVIAHAFGPGPGIGGDTHFDEDEIW--------SK 200
Query: 270 LSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTIS-SRTKKVELESDDIEGIQMLYG 326
+L V VHE+GH LGL HS+ +AIM+PT L +DDI GIQ LYG
Sbjct: 201 SYKGTNLFLVAVHELGHALGLDHSNDPKAIMFPTYGYIDLNTFHLSADDIRGIQSLYG 258
>MM08_RAT (O88766) Neutrophil collagenase precursor (EC 3.4.24.34)
(Matrix metalloproteinase-8) (MMP-8)
Length = 466
Score = 125 bits (314), Expect = 2e-28
Identities = 94/278 (33%), Positives = 122/278 (43%), Gaps = 40/278 (14%)
Query: 71 KNYFNHFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCGV 130
+NY F ++P+ + + + ++ Q+ F L TG+ D AT+ + KPRCGV
Sbjct: 37 ENYLRKFYHLPSNQFRSARNA--TMIAEKLKEMQRFFGLPETGKPDAATIEIMEKPRCGV 94
Query: 131 ADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENLDDATKQ 190
D SG F + PG P+W T + K
Sbjct: 95 PD---------SGDFLLT-------------PGSPKWTHTNLTYRIINHTPQMSKAEVKT 132
Query: 191 VFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP---T 247
AF WS +T+TFTE T +DI I F S DHGD FDG G LAHAF P
Sbjct: 133 EIEKAFKIWSVPSTLTFTE-TLEGEADINIAFVSRDHGDNSPFDGPNGILAHAFQPGRGI 191
Query: 248 DGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISSR 307
G H D E W + S +L V HE GH LGL HS+ A+MYP + R
Sbjct: 192 GGDAHFDSEETWTQD--------SKNYNLFLVAAHEFGHSLGLSHSTDPGALMYPNYAYR 243
Query: 308 TKKV-ELESDDIEGIQMLYGSNPN---FTGTTTATSRD 341
L DDI GIQ +YG + N TG +T T+ D
Sbjct: 244 EPSTYSLPQDDINGIQTIYGPSDNPVQPTGPSTPTACD 281
>MM16_RAT (O35548) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 125 bits (313), Expect = 2e-28
Identities = 89/272 (32%), Positives = 124/272 (44%), Gaps = 34/272 (12%)
Query: 71 KNYFN------HFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIV 124
+ YFN +GY+P P E ++SA+ Q+ + +N+TG++D T++++
Sbjct: 38 EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97
Query: 125 KPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENL 184
KPRCGV D G S KFN + +W T + +
Sbjct: 98 KPRCGVPDQTRG-----SSKFNIRRKRYALTGQ--------KWQHKHITYSIKNVTPKVG 144
Query: 185 DDATKQVFANAFNQWSKVTTITFTEA------TSYSSSDIKIGFYSGDHGDGEAFDGVLG 238
D T++ AF+ W VT +TF E DI I F SG HGD FDG G
Sbjct: 145 DPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGG 204
Query: 239 TLAHAFSP---TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSI 295
LAHA+ P G H D E W + + + DL V VHE+GH LGL HS+
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGN-----DLFLVAVHELGHALGLEHSND 259
Query: 296 EEAIMYPTIS-SRTKKVELESDDIEGIQMLYG 326
AIM P T +L +DD++GIQ +YG
Sbjct: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291
>MM16_MOUSE (Q9WTR0) Matrix metalloproteinase-16 precursor (EC
3.4.24.-) (MMP-16) (Membrane-type matrix
metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 125 bits (313), Expect = 2e-28
Identities = 89/272 (32%), Positives = 124/272 (44%), Gaps = 34/272 (12%)
Query: 71 KNYFN------HFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIV 124
+ YFN +GY+P P E ++SA+ Q+ + +N+TG++D T++++
Sbjct: 38 EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97
Query: 125 KPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENL 184
KPRCGV D G S KFN + +W T + +
Sbjct: 98 KPRCGVPDQTRG-----SSKFNIRRKRYALTGQ--------KWQHKHITYSIKNVTPKVG 144
Query: 185 DDATKQVFANAFNQWSKVTTITFTEA------TSYSSSDIKIGFYSGDHGDGEAFDGVLG 238
D T++ AF+ W VT +TF E DI I F SG HGD FDG G
Sbjct: 145 DPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGG 204
Query: 239 TLAHAFSP---TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSI 295
LAHA+ P G H D E W + + + DL V VHE+GH LGL HS+
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGN-----DLFLVAVHELGHALGLEHSND 259
Query: 296 EEAIMYPTIS-SRTKKVELESDDIEGIQMLYG 326
AIM P T +L +DD++GIQ +YG
Sbjct: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291
>MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13)
Length = 472
Score = 124 bits (312), Expect = 3e-28
Identities = 87/261 (33%), Positives = 115/261 (43%), Gaps = 40/261 (15%)
Query: 70 LKNYFNHFGYIPNGPPSNFTDDFDEALESAVRTYQKNFNLNITGELDDATMNYIVKPRCG 129
LK+Y Y P P ++ +R Q F L +TG+LDD T++ + KPRCG
Sbjct: 44 LKSY-----YYPLNPAGILKKTAANSVVDRLREMQSFFGLEVTGKLDDNTLDIMKKPRCG 98
Query: 130 VADIINGTTSMNSGKFNSSSTNFHTVAHYSFFPGQPRWPEGTQTLTYAFDPSENLDDATK 189
V D V Y+ FP +WP+ T + +
Sbjct: 99 VPD----------------------VGEYNVFPRTLKWPKMNLTYRIVNYTPDLTHSEVE 136
Query: 190 QVFANAFNQWSKVTTITFTEATSYSSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP--- 246
+ F AF WS VT + FT + ++DI I F + +HGD FDG G LAHAF P
Sbjct: 137 KAFKKAFKVWSDVTPLNFTRLYN-GTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPN 195
Query: 247 TDGRLHLDKAEDWVVNGDVTESSLSNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISS 306
G H D E W +S S +L V HE GH LGL HS A+M+P +
Sbjct: 196 YGGDAHFDDDETW--------TSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTY 247
Query: 307 RTKK-VELESDDIEGIQMLYG 326
K L DD++GIQ LYG
Sbjct: 248 TGKSHFVLPDDDVQGIQYLYG 268
>MM01_HUMAN (P03956) Interstitial collagenase precursor (EC
3.4.24.7) (Matrix metalloproteinase-1) (MMP-1)
(Fibroblast collagenase)
Length = 469
Score = 124 bits (311), Expect = 4e-28
Identities = 85/240 (35%), Positives = 115/240 (47%), Gaps = 47/240 (19%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q+ F L +TG+ D T+ + +PRCGV D VA +
Sbjct: 64 LKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPD----------------------VAQFV 101
Query: 160 FFPGQPRWPEGTQTLTYAFD------PSENLDDATKQVFANAFNQWSKVTTITFTEATSY 213
G PRW + LTY + P ++D A ++ AF WS VT +TFT+ S
Sbjct: 102 LTEGNPRWEQ--THLTYRIENYTPDLPRADVDHAIEK----AFQLWSNVTPLTFTKV-SE 154
Query: 214 SSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP---TDGRLHLDKAEDWVVNGDVTESSL 270
+DI I F GDH D FDG G LAHAF P G H D+ E W N
Sbjct: 155 GQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNN-------- 206
Query: 271 SNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTKKVELESDDIEGIQMLYGSNPN 330
+L V HE+GH LGL HS+ A+MYP+ + + V+L DDI+GIQ +YG + N
Sbjct: 207 FREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF-SGDVQLAQDDIDGIQAIYGRSQN 265
>MM01_HORSE (Q9XSZ5) Interstitial collagenase precursor (EC
3.4.24.7) (Matrix metalloproteinase-1) (MMP-1)
Length = 469
Score = 124 bits (311), Expect = 4e-28
Identities = 88/240 (36%), Positives = 113/240 (46%), Gaps = 47/240 (19%)
Query: 100 VRTYQKNFNLNITGELDDATMNYIVKPRCGVADIINGTTSMNSGKFNSSSTNFHTVAHYS 159
++ Q+ F L +TG+ D T+N + +PRCGV D VA +
Sbjct: 64 LKQMQEFFGLKVTGKPDAETLNVMKQPRCGVPD----------------------VAEFV 101
Query: 160 FFPGQPRWPEGTQTLTYAFD------PSENLDDATKQVFANAFNQWSKVTTITFTEATSY 213
G PRW E T LTY + P ++D A ++ AF WS V+ +TFT+ S
Sbjct: 102 LTEGNPRW-ENTH-LTYRIENYTPDLPRADVDQAIEK----AFQLWSNVSPLTFTKV-SE 154
Query: 214 SSSDIKIGFYSGDHGDGEAFDGVLGTLAHAFSP---TDGRLHLDKAEDWVVNGDVTESSL 270
+DI I F GDH D FDG G LAHAF P G H D+ E W N
Sbjct: 155 GQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPRIGGDAHFDEDETWTSN-------- 206
Query: 271 SNAVDLESVVVHEIGHLLGLGHSSIEEAIMYPTISSRTKKVELESDDIEGIQMLYGSNPN 330
+L V HE GH LGL HS+ A+MYP T V+L DDI GIQ +YG + N
Sbjct: 207 FRNYNLYRVAAHEFGHSLGLSHSTDIGALMYPNYFF-TGDVQLSQDDINGIQAIYGPSQN 265
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,714,264
Number of Sequences: 164201
Number of extensions: 2105156
Number of successful extensions: 5834
Number of sequences better than 10.0: 111
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 5443
Number of HSP's gapped (non-prelim): 140
length of query: 368
length of database: 59,974,054
effective HSP length: 112
effective length of query: 256
effective length of database: 41,583,542
effective search space: 10645386752
effective search space used: 10645386752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Medicago: description of AC144345.3