BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144345.11 - phase: 0
(339 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24... 122 2e-27
MM15_MOUSE (O54732) Matrix metalloproteinase-15 precursor (EC 3.... 71 4e-12
MM26_HUMAN (Q9NRE1) Matrix metalloproteinase-26 precursor (EC 3.... 67 6e-11
MM14_PIG (Q9XT90) Matrix metalloproteinase-14 precursor (EC 3.4.... 66 1e-10
MM14_MOUSE (P53690) Matrix metalloproteinase-14 precursor (EC 3.... 65 2e-10
MM12_RAT (Q63341) Macrophage metalloelastase precursor (EC 3.4.2... 64 5e-10
MM18_XENLA (O13065) Matrix metalloproteinase-18 precursor (EC 3.... 62 2e-09
MM15_HUMAN (P51511) Matrix metalloproteinase-15 precursor (EC 3.... 61 4e-09
MM14_HUMAN (P50281) Matrix metalloproteinase-14 precursor (EC 3.... 59 2e-08
MM14_RABIT (Q95220) Matrix metalloproteinase-14 precursor (EC 3.... 59 2e-08
MM12_MOUSE (P34960) Macrophage metalloelastase precursor (EC 3.4... 59 2e-08
MM14_RAT (Q10739) Matrix metalloproteinase-14 precursor (EC 3.4.... 57 5e-08
MM09_MOUSE (P41245) 92 kDa type IV collagenase precursor (EC 3.4... 57 7e-08
MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix... 56 1e-07
MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1 pr... 55 3e-07
MM03_RABIT (P28863) Stromelysin-1 precursor (EC 3.4.24.17) (Matr... 54 7e-07
MM10_MOUSE (O55123) Stromelysin-2 precursor (EC 3.4.24.22) (Matr... 53 1e-06
MM10_HUMAN (P09238) Stromelysin-2 precursor (EC 3.4.24.22) (Matr... 52 3e-06
MM03_MOUSE (P28862) Stromelysin-1 precursor (EC 3.4.24.17) (Matr... 52 3e-06
MM03_HUMAN (P08254) Stromelysin-1 precursor (EC 3.4.24.17) (Matr... 52 3e-06
>MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24.-)
(SMEP1)
Length = 305
Score = 122 bits (305), Expect = 2e-27
Identities = 93/309 (30%), Positives = 135/309 (43%), Gaps = 67/309 (21%)
Query: 4 QGLSQIKKHLSTFGYFRQFLLKFDDVLDEETISAIKTYQQFFNLQVTGNLNTETLQKISL 63
+GLS +K + GY FDD D+ +SAIKTYQ+ +NL VTG + TL++I
Sbjct: 52 KGLSNVKNYFHHLGYIPN-APHFDDNFDDTLVSAIKTYQKNYNLNVTGKFDINTLKQIMT 110
Query: 64 PRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDM---- 119
P RCG+PD+
Sbjct: 111 P------------------------------------------------RCGVPDIIINT 122
Query: 120 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVL 179
F + SD +F K + GT +LTY F P + AF++W+ +
Sbjct: 123 NKTTSFGMISDYTFFKDMPRWQAGTTQLTYAFSPEPRLDDTFKSAIARAFSKWTPVVNIA 182
Query: 180 NFSETTSYDDADIKIGFYHIYNNDIVD----DVVVGDSFISRNLDSNVKSGMIRLERSKF 235
F ETTSY+ A+IKI F + D ++G +F + G + ++
Sbjct: 183 -FQETTSYETANIKILFASKNHGDPYPFDGPGGILGHAFAPTD-------GRCHFDADEY 234
Query: 236 WVSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDS 295
WV+ + K FDLE+V +H+IGHLLGL HSSD +IMYP I P + +KV +
Sbjct: 235 WVA-SGDVTKSPVTSAFDLESVAVHEIGHLLGLGHSSDLRAIMYPSIPP-RTRKVNLAQD 292
Query: 296 DNQAIQQLY 304
D I++LY
Sbjct: 293 DIDGIRKLY 301
>MM15_MOUSE (O54732) Matrix metalloproteinase-15 precursor (EC
3.4.24.-) (MMP-15) (Membrane-type matrix
metalloproteinase 2) (MT-MMP 2) (MTMMP2)
(Membrane-type-2 matrix metalloproteinase) (MT2-MMP)
(MT2MMP)
Length = 657
Score = 70.9 bits (172), Expect = 4e-12
Identities = 73/277 (26%), Positives = 112/277 (40%), Gaps = 62/277 (22%)
Query: 36 SAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKG 95
SA+ Q F+ + VTG L+ ET + PRCG+PD ++G V +++ +
Sbjct: 77 SALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPD---QFGVHVKANLR---------RR 124
Query: 96 TKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGK 155
K+ T L GK ++ Y F + + T+KL +
Sbjct: 125 RKRYT---LTGKAWN---------NYHLTFSIQNY-------------TEKLGW------ 153
Query: 156 KFSLDMIEGFRNAFTRWSQTTRVLNFSETTSYDD--------ADIKIGFYHIYNNDIVDD 207
+ +E R AF W Q T ++ F E SYDD ADI + F ++ D
Sbjct: 154 ---YNSMEAVRRAFQVWEQVTPLV-FQEV-SYDDIRLRRRAEADIMVLFASGFHGDSSPF 208
Query: 208 VVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLG 267
VG G + + W F +L L V +H++GH LG
Sbjct: 209 DGVGGFLAHAYFPGPGLGGDTHFDADEPWT------FSSTDLHGISLFLVAVHELGHALG 262
Query: 268 LDHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
L+HSS+ +IM P + Q+ + D + IQQLY
Sbjct: 263 LEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLY 299
>MM26_HUMAN (Q9NRE1) Matrix metalloproteinase-26 precursor (EC
3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase)
Length = 261
Score = 67.0 bits (162), Expect = 6e-11
Identities = 75/290 (25%), Positives = 111/290 (37%), Gaps = 73/290 (25%)
Query: 17 GYFRQFLL--KFDDVLDEETISAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYE 74
GYF QF L K +L +ET + + Q F+ T L+ + + P CG+PD
Sbjct: 34 GYFHQFFLTKKESPLLTQETQTQLL---QQFHRNGTDLLDMQMHALLHQPHCGVPD---- 86
Query: 75 YGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFP 134
GSD S G + K T LTY +++P
Sbjct: 87 -----GSDTSISPGRCKWNKHT--LTYRI---------------------------INYP 112
Query: 135 KGNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETTSYDDADIKI 194
K P K Y NA + WS T ++ + DADIK+
Sbjct: 113 HDMK--PSAVKDSIY-----------------NAVSIWSNVTPLI--FQQVQNGDADIKV 151
Query: 195 GFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDL 254
F+ + D G L ++ G++ ++++ W + T Y +L
Sbjct: 152 SFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGY---------NL 202
Query: 255 ETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
V H+IGH LGL HS ++ SIMYP + Q++ D Q IQ LY
Sbjct: 203 FLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLY 252
>MM14_PIG (Q9XT90) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP)
Length = 580
Score = 66.2 bits (160), Expect = 1e-10
Identities = 69/300 (23%), Positives = 119/300 (39%), Gaps = 63/300 (21%)
Query: 13 LSTFGYFRQFLLKFDDVLDEETISA-IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDM 71
L +GY L+ +++SA I Q+F+ L+VTG + +T++ + PRCG+PD
Sbjct: 37 LQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADADTMKAMRRPRCGVPD- 95
Query: 72 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDV 131
++G ++ ++V R I +++++ +++
Sbjct: 96 --KFGAEIKANV--------------------------RRKRYAIQGLKWQH-----NEI 122
Query: 132 SFPKGNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETT------ 185
+F N + PK + T+ E R AF W T L F E
Sbjct: 123 TFCIQN-YTPKVGEYATF-------------EAIRKAFRVWESAT-PLRFREVPYAYIRE 167
Query: 186 -SYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYF 244
ADI I F ++ D G G + ++ W
Sbjct: 168 GHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWT------V 221
Query: 245 KKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
+ +L D+ V +H++GH LGL+HS+D +IM P + + + D D + IQQLY
Sbjct: 222 RNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLY 281
>MM14_MOUSE (P53690) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1) (MT-MMP)
Length = 582
Score = 65.1 bits (157), Expect = 2e-10
Identities = 70/300 (23%), Positives = 117/300 (38%), Gaps = 63/300 (21%)
Query: 13 LSTFGYFRQFLLKFDDVLDEETISA-IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDM 71
L +GY L+ +++SA I Q+F+ LQVTG + T+ + PRCG+PD
Sbjct: 39 LQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADLATMMAMRRPRCGVPD- 97
Query: 72 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDV 131
++G ++ ++V R I +++++ +++
Sbjct: 98 --KFGTEIKANV--------------------------RRKRYAIQGLKWQH-----NEI 124
Query: 132 SFPKGNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETT------ 185
+F N + PK + T+ E R AF W T L F E
Sbjct: 125 TFCIQN-YTPKVGEYATF-------------EAIRKAFRVWESAT-PLRFREVPYAYIRE 169
Query: 186 -SYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYF 244
ADI I F ++ D G G + ++ W
Sbjct: 170 GHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWT------V 223
Query: 245 KKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
+ +L D+ V +H++GH LGL+HS+D +IM P + + + D D + IQQLY
Sbjct: 224 QNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMSPFYQWMDTENFVLPDDDRRGIQQLY 283
>MM12_RAT (Q63341) Macrophage metalloelastase precursor (EC
3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12)
Length = 465
Score = 63.9 bits (154), Expect = 5e-10
Identities = 70/285 (24%), Positives = 106/285 (36%), Gaps = 74/285 (25%)
Query: 38 IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTK 97
++ QQFF L+VTG L+T TL
Sbjct: 60 LQEMQQFFGLEVTGQLDTSTL--------------------------------------- 80
Query: 98 KLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPG-KK 156
K RCG+PD+++ + P+ ++W + Y + P K+
Sbjct: 81 ---------KIMHTSRCGVPDVQHLR--------AVPQRSRWMKRYLTYRIYNYTPDMKR 123
Query: 157 FSLDMIEGFRNAFTRWSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDSFIS 216
+D I F+ AF WS T L F + +ADI I F + D D G +
Sbjct: 124 ADVDYI--FQKAFQVWSDVTP-LRFRKIHK-GEADITILFAFGDHGDFYDFDGKGGTLAH 179
Query: 217 RNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKES 276
G + ++ W Q +L V +H++GH LGL HS++ +S
Sbjct: 180 AFYPGPGIQGDAHFDEAETWTK---------SFQGTNLFLVAVHELGHSLGLRHSNNPKS 230
Query: 277 IMYPLIDPLQEKKVQITDSDNQAIQQLY----TNTAKANPNSDHS 317
IMYP L +++ D +IQ LY N + NP S S
Sbjct: 231 IMYPTYRYLHPNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPS 275
>MM18_XENLA (O13065) Matrix metalloproteinase-18 precursor (EC
3.4.24.-) (MMP-18) (Collagenase-4) (Collagenase 4)
(xCol4)
Length = 467
Score = 62.4 bits (150), Expect = 2e-09
Identities = 66/268 (24%), Positives = 100/268 (36%), Gaps = 70/268 (26%)
Query: 38 IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTK 97
++ Q+FF L+VTG L+ +T++ + PRCG+ +DVG + K + W K
Sbjct: 64 LEQMQKFFGLKVTGTLDPKTVEVMEKPRCGV--------YDVGQYSTVAKSSAW---QKK 112
Query: 98 KLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKF 157
LTY L F+ PD+
Sbjct: 113 DLTYRIL---NFT------PDLP------------------------------------- 126
Query: 158 SLDMIEGFRNAFTRWSQTTRVLNFSETTSYDD-ADIKIGFYHIYNNDIVDDVVVGDSFIS 216
D+ + AF WS T + + T Y++ +DI+I F + D G
Sbjct: 127 QADVETAIQRAFKVWSDVTPL---TFTRIYNEVSDIEISFTAGDHKDNSPFDGSGGILAH 183
Query: 217 RNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKES 276
N G + + W + Y +L V H+ GH LGL HS+D+ +
Sbjct: 184 AFQPGNGIGGDAHFDEDETWTKTSEIY---------NLFLVAAHEFGHSLGLSHSTDQGA 234
Query: 277 IMYPLIDPLQEKKVQITDSDNQAIQQLY 304
+MYP K Q+ D AIQ LY
Sbjct: 235 LMYPTYSNTDPKTFQLPQDDINAIQYLY 262
>MM15_HUMAN (P51511) Matrix metalloproteinase-15 precursor (EC
3.4.24.-) (MMP-15) (Membrane-type matrix
metalloproteinase 2) (MT-MMP 2) (MTMMP2)
(Membrane-type-2 matrix metalloproteinase) (MT2-MMP)
(MT2MMP) (SMCP-2)
Length = 669
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/276 (23%), Positives = 107/276 (37%), Gaps = 60/276 (21%)
Query: 36 SAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKG 95
SA+ Q+F+ + VTG L+ ET + + PRCG+PD ++G V +++
Sbjct: 81 SALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPD---QFGVRVKANLR----------- 126
Query: 96 TKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGK 155
++ Y L G+K++ Y T+KL +
Sbjct: 127 RRRKRYA-LTGRKWNNHHLTFSIQNY----------------------TEKLGW------ 157
Query: 156 KFSLDMIEGFRNAFTRWSQTTRVLNFSETTSYD-------DADIKIGFYHIYNNDIVDDV 208
+E R AF W Q T ++ F E D +ADI + F ++ D
Sbjct: 158 ---YHSMEAVRRAFRVWEQATPLV-FQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFD 213
Query: 209 VVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLGL 268
G G + + W F +L +L V +H++GH LGL
Sbjct: 214 GTGGFLAHAYFPGPGLGGDTHFDADEPWT------FSSTDLHGNNLFLVAVHELGHALGL 267
Query: 269 DHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
+HSS+ +IM P ++ + D + IQQLY
Sbjct: 268 EHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLY 303
>MM14_HUMAN (P50281) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1)
Length = 582
Score = 58.9 bits (141), Expect = 2e-08
Identities = 69/304 (22%), Positives = 107/304 (34%), Gaps = 71/304 (23%)
Query: 13 LSTFGYFRQFLLKFDDVLDEETISA-IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDM 71
L +GY L+ +++SA I Q+F+ LQVTG + +T++ + PR
Sbjct: 39 LQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPR------ 92
Query: 72 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDV 131
CG+PD ++G ++ ++V
Sbjct: 93 ------------------------------------------CGVPD---KFGAEIKANV 107
Query: 132 SFPK----GNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETT-- 185
+ G KW + P K E R AF W T L F E
Sbjct: 108 RRKRYAIQGLKWQHNEITFCIQNYTP-KVGEYATYEAIRKAFRVWESATP-LRFREVPYA 165
Query: 186 -----SYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPT 240
ADI I F ++ D G G + ++ W
Sbjct: 166 YIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWT--- 222
Query: 241 TTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAI 300
+ +L D+ V +H++GH LGL+HSSD +IM P + + + D D + I
Sbjct: 223 ---VRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGI 279
Query: 301 QQLY 304
QQLY
Sbjct: 280 QQLY 283
>MM14_RABIT (Q95220) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP)
Length = 582
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/304 (22%), Positives = 109/304 (35%), Gaps = 71/304 (23%)
Query: 13 LSTFGYFRQFLLKFDDVLDEETISA-IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDM 71
L +GY L+ +++SA I Q+F+ L+VTG +T+T++ + PR
Sbjct: 39 LQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADTDTMKAMRRPR------ 92
Query: 72 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDV 131
CG+PD ++G ++ ++V
Sbjct: 93 ------------------------------------------CGVPD---KFGAEIKANV 107
Query: 132 SFPK----GNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETT-- 185
+ G KW + P K E R AF W T L F E
Sbjct: 108 RRKRYAIQGLKWQHNEITFCIQNYTP-KVGEYATFEAIRKAFRVWESATP-LRFREVHYA 165
Query: 186 -----SYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPT 240
ADI I F ++ D G G + ++ W
Sbjct: 166 YIRDGREKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWT--- 222
Query: 241 TTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAI 300
+ +L D+ V +H++GH LGL+HS+D +IM P + +K + D + + I
Sbjct: 223 ---VRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTEKFLLPDDERRGI 279
Query: 301 QQLY 304
QQLY
Sbjct: 280 QQLY 283
>MM12_MOUSE (P34960) Macrophage metalloelastase precursor (EC
3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12)
Length = 462
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/193 (26%), Positives = 83/193 (42%), Gaps = 22/193 (11%)
Query: 113 RCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPG-KKFSLDMIEGFRNAFTR 171
RCG+PD+++ + P+ ++W + Y + P K+ +D I F+ AF
Sbjct: 84 RCGVPDVQHLR--------AVPQRSRWMKRYLTYRIYNYTPDMKREDVDYI--FQKAFQV 133
Query: 172 WSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLE 231
WS T L F + D+ADI I F + D G + G +
Sbjct: 134 WSDVTP-LRFRKLHK-DEADIMILFAFGAHGDFNYFDGKGGTLAHVFYPGPGIQGDAHFD 191
Query: 232 RSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQ 291
++ W Q +L V +H++GH LGL HS++ +SIMYP L +
Sbjct: 192 EAETWTK---------SFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFR 242
Query: 292 ITDSDNQAIQQLY 304
++ D + IQ LY
Sbjct: 243 LSADDIRNIQSLY 255
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/95 (28%), Positives = 47/95 (49%), Gaps = 13/95 (13%)
Query: 38 IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTK 97
++ QQFF L+ TG L+ TL + +PRCG+PD+++ + P+ ++W +
Sbjct: 57 LQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQHLR--------AVPQRSRWMKRYLT 108
Query: 98 KLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVS 132
Y + P K + D ++ F V SDV+
Sbjct: 109 YRIYNYTPDMKREDV-----DYIFQKAFQVWSDVT 138
>MM14_RAT (Q10739) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MT-MMP)
Length = 582
Score = 57.4 bits (137), Expect = 5e-08
Identities = 68/304 (22%), Positives = 107/304 (34%), Gaps = 71/304 (23%)
Query: 13 LSTFGYFRQFLLKFDDVLDEETISA-IKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDM 71
L +GY L+ +++SA I Q+F+ LQVTG +++T++ + PR
Sbjct: 39 LQQYGYLPPGDLRTHTQRSPQSLSAAIAAIQRFYGLQVTGKADSDTMKAMRRPR------ 92
Query: 72 RYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDV 131
CG+PD ++G ++ ++V
Sbjct: 93 ------------------------------------------CGVPD---KFGTEIKANV 107
Query: 132 SFPK----GNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETT-- 185
+ G KW + P K E R AF W T L F E
Sbjct: 108 RRKRYAIQGLKWQHNEITFCIQNYTP-KVGEYATFEAIRKAFRVWESATP-LRFREVPYA 165
Query: 186 -----SYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPT 240
ADI I F ++ D G G + ++ W
Sbjct: 166 YIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWT--- 222
Query: 241 TTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAI 300
+ +L D+ V +H++GH LGL+HS+D IM P + + + D D + I
Sbjct: 223 ---VQNEDLNGNDIFLVAVHELGHALGLEHSNDPSDIMAPFYQWMDTENFVLPDDDRRGI 279
Query: 301 QQLY 304
QQLY
Sbjct: 280 QQLY 283
>MM09_MOUSE (P41245) 92 kDa type IV collagenase precursor (EC
3.4.24.35) (92 kDa gelatinase) (Matrix
metalloproteinase-9) (MMP-9) (Gelatinase B) (GELB)
Length = 730
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/164 (28%), Positives = 71/164 (43%), Gaps = 13/164 (7%)
Query: 154 GKKFSLDMIEGFRNAFTRWSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDS 213
G+ +S +G + + RW TT N+ + Y ++ + N + V
Sbjct: 296 GRSYSACTTKGRSDGY-RWCATTA--NYDQDKLYGFCPTRVDATVVGGNSAGELCVFPFV 352
Query: 214 FISRNLDSNVKSGMIRLERSKFWVSPTTTYF--KKWEL---QEFDLETVVMHQIGHLLGL 268
F+ + S G + W + T+ + KKW Q + L V H+ GH LGL
Sbjct: 353 FLGKQYSSCTSDGR---RDGRLWCATTSNFDTDKKWGFCPDQGYSLFLVAAHEFGHALGL 409
Query: 269 DHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLYTNTAKANP 312
DHSS E++MYPL L+ + D D IQ LY +K +P
Sbjct: 410 DHSSVPEALMYPLYSYLEGFPLNKDDID--GIQYLYGRGSKPDP 451
Score = 37.0 bits (84), Expect = 0.071
Identities = 22/55 (40%), Positives = 31/55 (56%), Gaps = 9/55 (16%)
Query: 37 AIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKW 91
A+ Q+ +L TG L+++TL+ I PRCG+P DVG +F KG KW
Sbjct: 71 ALLMLQKQLSLPQTGELDSQTLKAIRTPRCGVP--------DVGRFQTF-KGLKW 116
>MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
(Transformation-associated protein 34A)
Length = 476
Score = 55.8 bits (133), Expect = 1e-07
Identities = 59/210 (28%), Positives = 88/210 (41%), Gaps = 37/210 (17%)
Query: 113 RCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLDMIE-----GFRN 167
RCG+PD VG +FP KW ++Y + ++LD+
Sbjct: 91 RCGVPD--------VGGFSTFPGSPKW---RKNHISYRIV---NYTLDLPRESVDSAIER 136
Query: 168 AFTRWSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGM 227
A W + T L FS S +ADI I F + D VG S G
Sbjct: 137 ALKVWEEVTP-LTFSRI-SEGEADIMISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGD 194
Query: 228 IRLERSKFW-VSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLID-PL 285
+ + W + P+ T +L V H++GH LGL HS++KES+MYP+
Sbjct: 195 AHFDDDEKWSLGPSGT----------NLFLVAAHELGHSLGLFHSNNKESLMYPVYRFST 244
Query: 286 QEKKVQITDSDNQAIQQLYTNTAKANPNSD 315
+ ++++ D + IQ LY A P+SD
Sbjct: 245 SQANIRLSQDDIEGIQSLY----GARPSSD 270
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 19/94 (20%)
Query: 9 IKKHLSTFGYFRQFLLKFDDVLDEE-----------TISAIKTYQQFFNLQVTGNLNTET 57
+++ ST +Q+L K+ + E + I+ Q+F L++TG L++ T
Sbjct: 24 VRQDHSTMDLAQQYLEKYYNFRKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNT 83
Query: 58 LQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKW 91
++ + PRCG+P DVG +FP KW
Sbjct: 84 VEMMHKPRCGVP--------DVGGFSTFPGSPKW 109
>MM07_RAT (P50280) Matrilysin precursor (EC 3.4.24.23) (Pump-1
protease) (Uterine metalloproteinase) (Matrix
metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 54.7 bits (130), Expect = 3e-07
Identities = 69/290 (23%), Positives = 104/290 (35%), Gaps = 72/290 (24%)
Query: 18 YFRQFLLKFDDVLDEETISAI---KTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYE 74
Y R+F L D ++ SA+ + Q+FF L TG L+ ++ + PRCG+P
Sbjct: 41 YLRKFYLH--DSKTKKATSAVDKLREMQKFFGLPETGKLSPRVMEIMQKPRCGVP----- 93
Query: 75 YGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFP 134
DV P KW ++ +TY + Y D+
Sbjct: 94 ---DVAEFSLMPNSPKWH---SRTVTYRIV-----------------SYTTDL------- 123
Query: 135 KGNKWFPKGTKKLTYGFLPGKKFSLDMIEGFRNAFTRWSQTTRVLNFSETTSYDDADIKI 194
+F +D I + A WS LNF + S+ ADI I
Sbjct: 124 --------------------PRFLVDQI--VKRALRMWSMQI-PLNF-KRVSWGTADIII 159
Query: 195 GFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDL 254
GF + D G++ G ++ ++W E +
Sbjct: 160 GFARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTD--------GEDSGVNF 211
Query: 255 ETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQEKKVQITDSDNQAIQQLY 304
V H++GH LGL HSS S+MYP + +T D IQ+LY
Sbjct: 212 LFVATHELGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLY 261
>MM03_RABIT (P28863) Stromelysin-1 precursor (EC 3.4.24.17) (Matrix
metalloproteinase-3) (MMP-3) (Transin-1) (SL-1)
Length = 478
Score = 53.5 bits (127), Expect = 7e-07
Identities = 70/301 (23%), Positives = 109/301 (35%), Gaps = 77/301 (25%)
Query: 20 RQFLLKFDDVLDEETISAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDV 79
+QF+ + D + I+ Q+F L+VTG L++ TL+ I PR
Sbjct: 50 KQFVKRKDS---SPVVKKIQEMQKFLGLEVTGKLDSNTLEVIRKPR-------------- 92
Query: 80 GSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKW 139
CG+PD VG +FP KW
Sbjct: 93 ----------------------------------CGVPD--------VGHFSTFPGTPKW 110
Query: 140 FPKGTKKLTYGFLPGKKFSLDMIEG-FRNAFTRWSQTTRVLNFSETTSYDDADIKIGFYH 198
+ P D ++ A W + T L FS +ADI I F
Sbjct: 111 TKTHLTYRIVNYTPD--LPRDAVDAAIEKALKVWEEVTP-LTFSRKYE-GEADIMISFGV 166
Query: 199 IYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVV 258
+ D + G+ +G + + W TT +L V
Sbjct: 167 REHGDFIPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGT---------NLFLVA 217
Query: 259 MHQIGHLLGLDHSSDKESIMYPLIDPLQE-KKVQITDSDNQAIQQLYTNTAKANPNSDHS 317
H++GH LGL HS++ E++MYP+ + + + +++ D IQ LY A A+P D+S
Sbjct: 218 AHELGHSLGLFHSANPEALMYPVYNAFTDLARFRLSQDDVDGIQSLY-GPAPASP--DNS 274
Query: 318 G 318
G
Sbjct: 275 G 275
>MM10_MOUSE (O55123) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
Length = 476
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/206 (28%), Positives = 81/206 (39%), Gaps = 29/206 (14%)
Query: 113 RCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPG-KKFSLDMIEGFRNAFTR 171
RCG+PD VG +FP KW + P + S+D A
Sbjct: 91 RCGVPD--------VGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVD--SAIEKALKV 140
Query: 172 WSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLE 231
W + T L FS S +ADI I F + D G S G + +
Sbjct: 141 WEEVTP-LTFSRI-SEGEADIMISFAVGEHGDFYPFDGPGQSLAHAYPPGPGFYGDVHFD 198
Query: 232 RSKFW-VSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLID-PLQEKK 289
+ W ++P+ T +L V H++GH LGL HS KES+MYP+
Sbjct: 199 DDEKWTLAPSGT----------NLFLVAAHELGHSLGLFHSDKKESLMYPVYRFSTSPAN 248
Query: 290 VQITDSDNQAIQQLYTNTAKANPNSD 315
++ D + IQ LY A P+SD
Sbjct: 249 FHLSQDDIEGIQSLY----GAGPSSD 270
Score = 43.5 bits (101), Expect = 8e-04
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 35 ISAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKW 91
+ I+ Q+F L++TG L++ T++ + PRCG+P DVG +FP KW
Sbjct: 61 VKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVP--------DVGGFSTFPGSPKW 109
>MM10_HUMAN (P09238) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
Length = 476
Score = 51.6 bits (122), Expect = 3e-06
Identities = 64/272 (23%), Positives = 94/272 (34%), Gaps = 71/272 (26%)
Query: 35 ISAIKTYQQFFNLQVTGNLNTETLQKISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPK 94
+ I+ Q+F L+VTG L+T+TL+ + PR
Sbjct: 60 VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPR----------------------------- 90
Query: 95 GTKKLTYGFLPGKKFSLLRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPG 154
CG+PD VG SFP KW + P
Sbjct: 91 -------------------CGVPD--------VGHFSSFPGMPKWRKTHLTYRIVNYTPD 123
Query: 155 KKFSLDMIEG-FRNAFTRWSQTTRVLNFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDS 213
D ++ A W + T L FS +ADI I F + D G S
Sbjct: 124 --LPRDAVDSAIEKALKVWEEVTP-LTFSRLYE-GEADIMISFAVKEHGDFYSFDGPGHS 179
Query: 214 FISRNLDSNVKSGMIRLERSKFWVSPTTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSD 273
G I + + W + +L V H++GH LGL HS++
Sbjct: 180 LAHAYPPGPGLYGDIHFDDDEKWTE---------DASGTNLFLVAAHELGHSLGLFHSAN 230
Query: 274 KESIMYPLIDPLQE-KKVQITDSDNQAIQQLY 304
E++MYPL + E + +++ D IQ LY
Sbjct: 231 TEALMYPLYNSFTELAQFRLSQDDVNGIQSLY 262
>MM03_MOUSE (P28862) Stromelysin-1 precursor (EC 3.4.24.17) (Matrix
metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2)
Length = 477
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/315 (22%), Positives = 112/315 (35%), Gaps = 79/315 (25%)
Query: 5 GLSQIKKHLSTFGYF----RQFLLKFDDVLDEETISAIKTYQQFFNLQVTGNLNTETLQK 60
G+ ++K+L + +QF+ K D L + I+ Q+F L++TG L++ T++
Sbjct: 30 GMELLQKYLENYYGLAKDVKQFIKKKDSSL---IVKKIQEMQKFLGLEMTGKLDSNTMEL 86
Query: 61 ISLPRCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMR 120
+ PR CG+PD
Sbjct: 87 MHKPR------------------------------------------------CGVPD-- 96
Query: 121 YEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPG-KKFSLDMIEGFRNAFTRWSQTTRVL 179
VG +FP KW + P + S+D A W + T L
Sbjct: 97 ------VGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVD--SAIEKALKVWEEVTP-L 147
Query: 180 NFSETTSYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSP 239
FS S +ADI I F + D V G +G + + W
Sbjct: 148 TFSRI-SEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERWTED 206
Query: 240 TTTYFKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQE-KKVQITDSDNQ 298
T +L V H++GH LGL HS+ E++MYP+ + + ++ D
Sbjct: 207 VTGT---------NLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVD 257
Query: 299 AIQQLYTNTAKANPN 313
IQ LY T A+P+
Sbjct: 258 GIQSLY-GTPTASPD 271
>MM03_HUMAN (P08254) Stromelysin-1 precursor (EC 3.4.24.17) (Matrix
metalloproteinase-3) (MMP-3) (Transin-1) (SL-1)
Length = 477
Score = 51.6 bits (122), Expect = 3e-06
Identities = 68/302 (22%), Positives = 110/302 (35%), Gaps = 72/302 (23%)
Query: 6 LSQIKKHLSTFGYFRQFLLKFDDVLDE-ETISAIKTYQQFFNLQVTGNLNTETLQKISLP 64
++ ++K+L + ++ + +F D + I+ Q+F L+VTG L+++TL+ + P
Sbjct: 31 MNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKP 90
Query: 65 RCGIPDMRYEYGFDVGSDVSFPKGNKWFPKGTKKLTYGFLPGKKFSLLRCGIPDMRYEYG 124
R CG+PD
Sbjct: 91 R------------------------------------------------CGVPD------ 96
Query: 125 FDVGSDVSFPKGNKWFPKGTKKLTYGFLPG-KKFSLDMIEGFRNAFTRWSQTTRVLNFSE 183
VG +FP KW + P K ++D A W + T L FS
Sbjct: 97 --VGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVD--SAVEKALKVWEEVTP-LTFSR 151
Query: 184 TTSYDDADIKIGFYHIYNNDIVDDVVVGDSFISRNLDSNVKSGMIRLERSKFWVSPTTTY 243
+ADI I F + D G+ +G + + W TT
Sbjct: 152 LYE-GEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGT 210
Query: 244 FKKWELQEFDLETVVMHQIGHLLGLDHSSDKESIMYPLIDPLQE-KKVQITDSDNQAIQQ 302
+L V H+IGH LGL HS++ E++MYPL L + + +++ D IQ
Sbjct: 211 ---------NLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQS 261
Query: 303 LY 304
LY
Sbjct: 262 LY 263
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.140 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,365,282
Number of Sequences: 164201
Number of extensions: 1845021
Number of successful extensions: 3831
Number of sequences better than 10.0: 93
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 3653
Number of HSP's gapped (non-prelim): 182
length of query: 339
length of database: 59,974,054
effective HSP length: 111
effective length of query: 228
effective length of database: 41,747,743
effective search space: 9518485404
effective search space used: 9518485404
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Medicago: description of AC144345.11