Medicago
BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC140022.3 - phase: 0 
         (1079 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote...   522  e-147
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote...   521  e-147
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote...   519  e-146
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote...   495  e-139
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote...   492  e-138
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)   491  e-138
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote...   491  e-138
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote...   490  e-138
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote...   490  e-138
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein...   483  e-135
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,...   459  e-128
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,...   447  e-125
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s...   444  e-124
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,...   432  e-120
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote...   407  e-113
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g...   382  e-105
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g...   369  e-101
AB10_MOUSE (Q9JI39) ATP-binding cassette, sub-family B, member 1...   303  2e-81
AB10_HUMAN (Q9NRK6) ATP-binding cassette, sub-family B, member 1...   298  5e-80
ABC8_HUMAN (Q9NUT2) ATP-binding cassette, sub-family B, member 8...   298  7e-80

>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein
           1)
          Length = 1276

 Score =  522 bits (1345), Expect = e-147
 Identities = 299/794 (37%), Positives = 460/794 (57%), Gaps = 86/794 (10%)

Query: 25  IVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSS---------- 74
           +V  + +F +A  LD   M++GT++A+ +G A PLM L+ G + ++F S           
Sbjct: 32  VVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNN 91

Query: 75  ----NQSEVLNQVSK--VSLLFVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLKT 126
               N S++  ++ +   +  + Y  IG+G  I +++QVS W +   RQ  +IR  +   
Sbjct: 92  ATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHA 151

Query: 127 ILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWR 186
           I+ Q+I +FD   + GE+ +R++ D   I E +G+K+G F Q  +TFFGGF+I F +GW+
Sbjct: 152 IMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210

Query: 187 LALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKA 246
           L LV+LA  P + ++    A +++    +   AYA+AG VA + + ++RTV +F G+KK 
Sbjct: 211 LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270

Query: 247 IEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMT 306
           +E+YN+ ++ A    ++++I + I MG   L+I+ SY LA WYG+ LVI+K Y+ G V+T
Sbjct: 271 LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330

Query: 307 VVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIE 366
           V  A++ G+ S+GQ SP++ AFA  + AAY++F  I  KP ID++  +G   ++IKG++E
Sbjct: 331 VFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390

Query: 367 LRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLI 426
            +++HF YP+R DV+I  G +L V SG T ALVG SG GKST + LL+R YDP  G V I
Sbjct: 391 FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450

Query: 427 DGVNLKNLQLRWIREQIGLVSQE---------------RQN------------------- 452
           DG +++ + +R++RE IG+VSQE               R+N                   
Sbjct: 451 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510

Query: 453 --------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEAL 498
                         G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ AL
Sbjct: 511 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570

Query: 499 EKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGE 558
           +K    RTTIV+AHRL+T+ +AD IA    G IVE+G H EL M   G Y +L+  Q   
Sbjct: 571 DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEEL-MREKGIYFKLVMTQTAG 629

Query: 559 KEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDAN 617
            E E G+   E     DNL++      S     S +R  S   S+   H Q      D  
Sbjct: 630 NEIELGNEVGESKNEIDNLDM-----SSKDSASSLIRRRSTRRSIRGPHDQ------DRK 678

Query: 618 IEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVIS 677
           +   +  + + P +    S WR+ KLN  E P  ++G   A+VNG + P F  +FS V+ 
Sbjct: 679 LSTKEALDEDVPPI----SFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVG 734

Query: 678 MFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIV 735
           +F +    E +R +S  +SL+++ LG+++ + F L+ + FG AG  L +R+R + F  ++
Sbjct: 735 VFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSML 794

Query: 736 HQEIRWFDDPAHSS 749
            Q++ WFD+P +++
Sbjct: 795 RQDVSWFDNPKNTT 808



 Score =  348 bits (892), Expect = 6e-95
 Identities = 208/598 (34%), Positives = 321/598 (52%), Gaps = 54/598 (9%)

Query: 14   STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
            ST++ +++    + F+++    +  +    ++G   A+ NG   P  +++  KV+  F  
Sbjct: 680  STKEALDEDVPPISFWRILKL-NSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTR 738

Query: 74   SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
            +   E     S + SLLF+ L + S IT FLQ   +   GE  + R+R +  K++L+QD+
Sbjct: 739  NTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDV 798

Query: 133  AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
            ++FD   NT G + +R++ D   ++ A G ++    Q  +    G +I+ I GW+L L+L
Sbjct: 799  SWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLL 858

Query: 192  LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
            LA VP I +AG     +++  A++ +     +G +A + + + RTV S T E+K    Y 
Sbjct: 859  LAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYA 918

Query: 252  SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
              ++I Y   ++++   GI       +++ SY     +G+ LV  +      V+ V  A+
Sbjct: 919  QSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAI 978

Query: 312  VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
            V G+M++GQ S     +A  K +A  +   I++ P ID+Y T GL    ++G+++  +V 
Sbjct: 979  VFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVV 1038

Query: 372  FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
            F YP RPD+ +  G +L V  G T ALVG SG GKSTV+ LLERFYDP AG V +DG  +
Sbjct: 1039 FNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEV 1098

Query: 432  KNLQLRWIREQIGLVSQE------------------------------------------ 449
              L ++W+R  +G+VSQE                                          
Sbjct: 1099 NQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESL 1158

Query: 450  --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
                       GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K 
Sbjct: 1159 PDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1218

Query: 502  ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
               RT IV+AHRL+TI +AD I V+Q GK+ E GTH +L +   G Y  ++ +Q G K
Sbjct: 1219 REGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQL-LAQKGIYFSMVSVQAGAK 1275



 Score =  319 bits (817), Expect = 3e-86
 Identities = 168/330 (50%), Positives = 221/330 (66%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV     TF  +  VF ++   AM+V Q S+  PD  KA  SA+ I
Sbjct: 946  MYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHI 1005

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P IDS S  G+   T+ GN++   V F+YPTRPDI + + L L +   +T+AL
Sbjct: 1006 IMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLAL 1065

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G V LDG ++    + WLR  +G+V QEPILF+ SI 
Sbjct: 1066 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIA 1125

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      ++DEI  AA  AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1126 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1185

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1186 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1245

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
            G V E G H +L+    G+Y S+V++ + A
Sbjct: 1246 GKVKEHGTHQQLLAQ-KGIYFSMVSVQAGA 1274



 Score =  317 bits (813), Expect = 8e-86
 Identities = 163/323 (50%), Positives = 223/323 (68%), Gaps = 2/323 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ G+ LV  ++ +  ++  VFF++ + A S+ Q+S        A  +A  I
Sbjct: 303  IYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEI 362

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            FNI+D+KP IDS S +G   + + GN+E ++++FSYP+R D+QI K L L + S +TVAL
Sbjct: 363  FNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVAL 422

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + LL+R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF  +I 
Sbjct: 423  VGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIA 482

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+E+  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIAIARA
Sbjct: 483  ENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 541

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA    G
Sbjct: 542  LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGG 601

Query: 1050 MVAEKGRHDELMNNTHGVYASLV 1072
            ++ E+G H+ELM    G+Y  LV
Sbjct: 602  VIVEQGNHEELMRE-KGIYFKLV 623


>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein
           3) (MDR1A)
          Length = 1276

 Score =  521 bits (1342), Expect = e-147
 Identities = 297/787 (37%), Positives = 459/787 (57%), Gaps = 85/787 (10%)

Query: 31  LFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS----SNQSEVLNQVSKV 86
           +F +A  LD   M++GT++A+ +G A PLM L+ G + ++F S    S  S  +++  K 
Sbjct: 38  MFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKR 97

Query: 87  SLL-----------FVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIA 133
           ++            + Y  IG+G  I +++QVS W +   RQ  +IR  +   I+ Q+I 
Sbjct: 98  AMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIG 157

Query: 134 FFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLA 193
           +FD   + GE+ +R++ D   I E +G+K+G F Q  +TFFGGF+I F +GW+L LV+LA
Sbjct: 158 WFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILA 216

Query: 194 CVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSK 253
             P + ++    A +++    +   AYA+AG VA + + ++RTV +F G+KK +E+YN+ 
Sbjct: 217 ISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNN 276

Query: 254 IKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVT 313
           ++ A    ++++I + I MG   L+I+ SY LA WYG+ LVI+K Y+ G V+TV  +++ 
Sbjct: 277 LEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLI 336

Query: 314 GSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFR 373
           G+ S+GQ SP++ AFA  + AAY++F+ I  KP ID++  SG   ++I+G++E +++HF 
Sbjct: 337 GAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFS 396

Query: 374 YPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKN 433
           YP+R +V+I  G +L V SG T ALVG SG GKST + L++R YDP  G V IDG +++ 
Sbjct: 397 YPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRT 456

Query: 434 LQLRWIREQIGLVSQE-------------------------------------------- 449
           + +R++RE IG+VSQE                                            
Sbjct: 457 INVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQF 516

Query: 450 ----RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKR 505
                + G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ AL+K    R
Sbjct: 517 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGR 576

Query: 506 TTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAE-GS 564
           TTIV+AHRL+T+ +AD IA    G IVE+G H EL M   G Y +L+  Q    E E G+
Sbjct: 577 TTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMTQTAGNEIELGN 635

Query: 565 RSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVD 624
            + +     DNL++    +GS     S +R  S   S+   H Q      D  +   +  
Sbjct: 636 EACKSKDEIDNLDMSSKDSGS-----SLIRRRSTRKSICGPHDQ------DRKLSTKEAL 684

Query: 625 NNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYK--P 682
           + + P      S WR+ KLN  E P  ++G   A++NG + P F  +FS V+ +F    P
Sbjct: 685 DEDVPPA----SFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGP 740

Query: 683 PEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWF 742
           PE QR+ S  +SL+++ LG+++ + F L+ + FG AG  L +R+R + F  ++ Q++ WF
Sbjct: 741 PETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWF 800

Query: 743 DDPAHSS 749
           DDP +++
Sbjct: 801 DDPKNTT 807



 Score =  347 bits (891), Expect = 8e-95
 Identities = 207/570 (36%), Positives = 308/570 (53%), Gaps = 53/570 (9%)

Query: 44   IIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKV-SLLFVYLAIGSGITSF 102
            ++G   A+ NG   P  +++  KV+  F +    E   Q S + SLLF+ L I S IT F
Sbjct: 708  VVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFF 767

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
            LQ   +   GE  + R+R +  K++L+QD+++FD   NT G + +R++ D   ++ A G 
Sbjct: 768  LQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGS 827

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            ++    Q  +    G +I+ I GW+L L+LLA VP I +AG     +++  A++ +    
Sbjct: 828  RLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELE 887

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
             +G +A + + + RTV S T E+K    Y   ++I Y   ++++   GI       +++ 
Sbjct: 888  GSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYF 947

Query: 282  SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
            SY     +G+ LV  +      V+ V  A+V G+M++GQ S     +A    +A  +   
Sbjct: 948  SYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRI 1007

Query: 342  IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
            I++ P+ID+Y T GL    ++G+++     F YP RP + +  G SL V  G T ALVG 
Sbjct: 1008 IEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGS 1067

Query: 402  SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
            SG GKSTV+ LLERFYDP AG V +DG  +K L ++W+R Q+G+VSQE            
Sbjct: 1068 SGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENI 1127

Query: 450  --------------------------------------RQNGTQLSGGQKQRIAIARAIL 471
                                                     GTQLSGGQKQRIAIARA++
Sbjct: 1128 AYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALV 1187

Query: 472  KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
            + P ILLLDEATSALD ESE +VQEAL+K    RT IV+AHRL+TI +AD I V+Q GK+
Sbjct: 1188 RQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKV 1247

Query: 532  VERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
             E GTH +L +   G Y  ++ +Q G K +
Sbjct: 1248 KEHGTHQQL-LAQKGIYFSMVSVQAGAKRS 1276



 Score =  320 bits (819), Expect = 2e-86
 Identities = 167/330 (50%), Positives = 222/330 (66%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV  +  TF  +  VF ++   AM+V Q S+  PD  KA  SA+ I
Sbjct: 945  MYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHI 1004

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P+IDS S  G+    + GN++     F+YPTRP I + + L+L +   +T+AL
Sbjct: 1005 IRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLAL 1064

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G V LDG +IK   + WLR Q+G+V QEPILF+ SI 
Sbjct: 1065 VGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIA 1124

Query: 930  ANIAYGKEDGATE-DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG        +EI+ AA  AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1125 ENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1184

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1185 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1244

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
            G V E G H +L+    G+Y S+V++ + A
Sbjct: 1245 GKVKEHGTHQQLLAQ-KGIYFSMVSVQAGA 1273



 Score =  316 bits (810), Expect = 2e-85
 Identities = 163/323 (50%), Positives = 221/323 (67%), Gaps = 2/323 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ G+ LV  ++ +  ++  VFFS+ + A SV Q+S        A  +A  +
Sbjct: 302  IYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEV 361

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F I+D+KP IDS S  G   + + GN+E ++++FSYP+R ++QI K L L + S +TVAL
Sbjct: 362  FKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVAL 421

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + L++R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF  +I 
Sbjct: 422  VGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIA 481

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+ED  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIAIARA
Sbjct: 482  ENIRYGRED-VTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA 540

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA    G
Sbjct: 541  LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGG 600

Query: 1050 MVAEKGRHDELMNNTHGVYASLV 1072
            ++ E+G HDELM    G+Y  LV
Sbjct: 601  VIVEQGNHDELMRE-KGIYFKLV 622


>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein
           1) (CD243 antigen)
          Length = 1280

 Score =  519 bits (1336), Expect = e-146
 Identities = 291/808 (36%), Positives = 468/808 (57%), Gaps = 86/808 (10%)

Query: 12  SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
           ++ +++   +    V  + +F +++ LD   M++GT++A+ +G   PLM L+ G++ + F
Sbjct: 20  NNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIF 79

Query: 72  GSS-NQSEVLNQVSKVSLL-----------------FVYLAIGSGI--TSFLQVSCWMVT 111
            ++ N  ++++ ++  S +                 + Y  IG+G+   +++QVS W + 
Sbjct: 80  ANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA 139

Query: 112 GERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGS 171
             RQ  +IR  +   I++Q+I +FD   + GE+ +R++ D   I E +G+K+G F Q  +
Sbjct: 140 AGRQIHKIRKQFFHAIMRQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQSMA 198

Query: 172 TFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTV 231
           TFF GF++ F +GW+L LV+LA  P + ++ A  A +++    +  +AYA+AG VA + +
Sbjct: 199 TFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVL 258

Query: 232 GSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGS 291
            ++RTV +F G+KK +E+YN  ++ A    ++++I + I +G   L+I+ SY LA WYG+
Sbjct: 259 AAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGT 318

Query: 292 KLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAY 351
            LV++  Y+ G V+TV  +++ G+ S+GQ SPS+ AFA  + AAY++F+ I  KP ID+Y
Sbjct: 319 TLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSY 378

Query: 352 DTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVIS 411
             SG   ++IKG++E R+VHF YP+R +V+I  G +L V SG T ALVG SG GKST + 
Sbjct: 379 SKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQ 438

Query: 412 LLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------RQN---- 452
           L++R YDP  G V +DG +++ + +R++RE IG+VSQE               R+N    
Sbjct: 439 LMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 498

Query: 453 -----------------------------GTQLSGGQKQRIAIARAILKNPKILLLDEAT 483
                                        G QLSGGQKQRIAIARA+++NPKILLLDEAT
Sbjct: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558

Query: 484 SALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMD 543
           SALD ESE +VQ AL+K    RTTIV+AHRL+T+ +AD IA    G IVE+G H EL M 
Sbjct: 559 SALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL-MK 617

Query: 544 PHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
             G Y +L+ +Q    E E   +++  K      ID     S+  R S +R        S
Sbjct: 618 EKGIYFKLVTMQTAGNEVELENAADESK----SEIDALEMSSNDSRSSLIR------KRS 667

Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
            R S    +  D  +   +  +   P +    S WR+ KLN  E P  ++G   A++NG 
Sbjct: 668 TRRSVRGSQAQDRKLSTKEALDESIPPV----SFWRIMKLNLTEWPYFVVGVFCAIINGG 723

Query: 664 VFPIFGFLFSAVISMFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGK 721
           + P F  +FS +I +F +   PE +R+ S  +SL+++ LG+++ + F L+ + FG AG  
Sbjct: 724 LQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEI 783

Query: 722 LIERIRSLTFAKIVHQEIRWFDDPAHSS 749
           L +R+R + F  ++ Q++ WFDDP +++
Sbjct: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTT 811



 Score =  354 bits (908), Expect = 8e-97
 Identities = 214/598 (35%), Positives = 327/598 (53%), Gaps = 54/598 (9%)

Query: 14   STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
            ST++ ++++   V F+++    +  +    ++G   A+ NG   P   ++  K+I  F  
Sbjct: 683  STKEALDESIPPVSFWRIMKL-NLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 741

Query: 74   SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
             +  E   Q S + SLLF+ L I S IT FLQ   +   GE  + R+R +  +++L+QD+
Sbjct: 742  IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801

Query: 133  AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
            ++FD   NT G + +R++ D   ++ A+G ++    Q  +    G +I+FI GW+L L+L
Sbjct: 802  SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861

Query: 192  LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
            LA VP I +AG     +++  A++ +     AG +A + + + RTV S T E+K    Y 
Sbjct: 862  LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYA 921

Query: 252  SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
              +++ Y   ++++   GI       +++ SY     +G+ LV  K  +   V+ V  A+
Sbjct: 922  QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV 981

Query: 312  VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
            V G+M++GQ S     +A  K +A  +   I++ P ID+Y T GL+   ++G++   +V 
Sbjct: 982  VFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVV 1041

Query: 372  FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
            F YP RPD+ +  G SL V  G T ALVG SG GKSTV+ LLERFYDP AG+VL+DG  +
Sbjct: 1042 FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1101

Query: 432  KNLQLRWIREQIGLVSQE------------------------------------------ 449
            K L ++W+R  +G+VSQE                                          
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1161

Query: 450  --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
                       GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K 
Sbjct: 1162 PNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1221

Query: 502  ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
               RT IV+AHRL+TI +AD I V Q G++ E GTH +L +   G Y  ++ +Q G K
Sbjct: 1222 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL-LAQKGIYFSMVSVQAGTK 1278



 Score =  322 bits (824), Expect = 4e-87
 Identities = 168/328 (51%), Positives = 226/328 (68%), Gaps = 2/328 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV H+  +F ++  VF ++   AM+V Q S+  PD  KA  SAA I
Sbjct: 949  MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P IDS S +G+   T+ GN+    V F+YPTRPDI + + L+L +   +T+AL
Sbjct: 1009 IMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1068

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G+VLLDG +IK   + WLR  +G+V QEPILF+ SI 
Sbjct: 1069 VGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIA 1128

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      +++EI+ AA  AN H FI SLP+ Y T VG++GTQLSGGQKQRIAIAR
Sbjct: 1129 ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIAR 1188

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I V +N
Sbjct: 1189 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1248

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
            G V E G H +L+    G+Y S+V++ +
Sbjct: 1249 GRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1275



 Score =  317 bits (811), Expect = 1e-85
 Identities = 164/330 (49%), Positives = 224/330 (67%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ G+ LV   + +  ++  VFFS+ + A SV Q+S        A  +A  I
Sbjct: 306  IYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEI 365

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F I+D+KP IDS S  G   + + GN+E ++V+FSYP+R +++I K L L + S +TVAL
Sbjct: 366  FKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVAL 425

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + L++R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF  +I 
Sbjct: 426  VGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIA 485

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+E+  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIAIARA
Sbjct: 486  ENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA   +G
Sbjct: 545  LVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDG 604

Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            ++ EKG HDELM    G+Y  LV + +  +
Sbjct: 605  VIVEKGNHDELMKE-KGIYFKLVTMQTAGN 633


>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein
           3)
          Length = 1281

 Score =  495 bits (1275), Expect = e-139
 Identities = 295/811 (36%), Positives = 456/811 (55%), Gaps = 98/811 (12%)

Query: 12  SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
           S+  +    K N I P   LF ++D  D   M++GTI A+A+G   PLM ++ G++ + F
Sbjct: 27  SNQGRNKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKF 85

Query: 72  GSS---------------NQSEVLNQVSKVSLLFVYLAIGSGI--TSFLQVSCWMVTGER 114
            ++               N   +L +       + Y  +G G+   +++QVS W +   R
Sbjct: 86  VNNAGNFSLPVNFSLSMINPGRILEE-EMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGR 144

Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
           Q  +IR  +   IL+Q++ +FD +  T E+ +R++ D   I E +G+KVG F Q  +TFF
Sbjct: 145 QIKKIRQNFFHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203

Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
            GF++ FI+GW+L LV++A  P + ++ A  A +++  + +   AYA+AG VA + +G++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 263

Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
           RTV +F G+ K +E+Y   ++ A    ++++I++ I MG   L+I+ SY LA WYGS LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323

Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
           I+K Y  G  MTV  +++ G+ S+GQ +P + AFA  + AAY +F+ I   PKID++   
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383

Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
           G   + IKG+++  DVHF YP+R +++I  G +L V SG T ALVG SG GK+T + LL+
Sbjct: 384 GHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQ 443

Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
           R YDP  G + IDG +++N  +R++RE IG+VSQE                         
Sbjct: 444 RLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIK 503

Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
                                   + G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563

Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
           D ESE  VQ AL+K    RTTIV+AHRL+T+ +AD IA  + G IVE+G+HSEL M   G
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MQKEG 622

Query: 547 AYSQLIRLQEG-------EKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQT 599
            Y +L+ +Q         E E E S     D    N     H+  +ST++       S  
Sbjct: 623 VYFKLVNMQTSGSQILSQEFEVELSEEKAADGMTPN-GWKSHIFRNSTKK-------SLK 674

Query: 600 SSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAM 659
           SS +H H          +++  ++D N  P      S  ++ KLNK E P  ++GT+ A+
Sbjct: 675 SSRAHHHR--------LDVDADELDANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAI 721

Query: 660 VNGVVFPIFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTA 718
           VNG + P    + S +I++F    +  ++++   +SLV++GLG+++   F L+ + FG A
Sbjct: 722 VNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKA 781

Query: 719 GGKLIERIRSLTFAKIVHQEIRWFDDPAHSS 749
           G  L  R+RS+ F  ++ Q++ WFDD  +S+
Sbjct: 782 GEILTTRLRSMAFKAMLRQDMSWFDDYKNST 812



 Score =  348 bits (893), Expect = 4e-95
 Identities = 210/587 (35%), Positives = 316/587 (53%), Gaps = 53/587 (9%)

Query: 26   VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSK 85
            V F K+    ++ +    ++GT+ A+ NG   P ++++L ++I  FG  + +    + + 
Sbjct: 697  VSFLKVLKL-NKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNL 755

Query: 86   VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEV 144
             SL+F+ L + S  T FLQ   +   GE  + R+RS+  K +L+QD+++FD   N TG +
Sbjct: 756  FSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGAL 815

Query: 145  ISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAF 204
             +R++ D   +Q A G ++    Q  +    G +I+FI GW+L L+LL+ VP I V+G  
Sbjct: 816  STRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIV 875

Query: 205  MAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQ 264
               ++A  A R + A   AG +A + + ++RTV S T E+K    Y  K+   Y   VQ 
Sbjct: 876  EMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQM 935

Query: 265  SIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPS 324
            +   GI        ++ SY     +G+ L++        V+ V  A+V G+++LG  S  
Sbjct: 936  AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 995

Query: 325  LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
               +A  K +A  +F   +R+P ID+Y   GL  +  +G +   +V F YP R ++ +  
Sbjct: 996  APDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQ 1055

Query: 385  GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
            G SL V  G T ALVG SG GKSTV+ LLERFYDP AG VL+DG   K L ++W+R Q+G
Sbjct: 1056 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLG 1115

Query: 445  LVSQE--------------------------------------------------RQNGT 454
            +VSQE                                                     GT
Sbjct: 1116 IVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGT 1175

Query: 455  QLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRL 514
            QLSGGQKQR+AI RA+++ P++LLLDEATSALD ESE +VQEAL+K    RT IV+AHRL
Sbjct: 1176 QLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1235

Query: 515  TTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
            +TI +AD I V+Q GK+ E GTH +L +   G Y  ++ +Q G + +
Sbjct: 1236 STIQNADLIVVIQNGKVKEHGTHQQL-LAQKGIYFSMVNIQAGAQNS 1281



 Score =  305 bits (782), Expect = 3e-82
 Identities = 161/330 (48%), Positives = 220/330 (65%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ GS LV  ++ T      VFFS+ + A SV Q++        A  +A  I
Sbjct: 308  IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 367

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F+I+D+ P IDS S  G   +++ GN++   V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 368  FDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVAL 427

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GK+T + LL+R YDP  G + +DG DI+ F + +LR+ +G+V QEP+LF+ +I 
Sbjct: 428  VGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIA 487

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+    T +EI  A   ANA+ FI  LP  +DT VGERG QLSGGQKQRIAIARA
Sbjct: 488  ENIRYGR-GNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE  VQ ALD+    RTT+++AHRL+T+R AD IA  ++G
Sbjct: 547  LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606

Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            ++ E+G H ELM    GVY  LV + ++ S
Sbjct: 607  VIVEQGSHSELMQK-EGVYFKLVNMQTSGS 635



 Score =  304 bits (779), Expect = 7e-82
 Identities = 157/330 (47%), Positives = 224/330 (67%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ L+ +    F ++  VF ++   A+++  +S+  PD  KA  SAA +
Sbjct: 950  MYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1009

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F++ + +P IDS S +G+  +   G++    V F+YPTR ++ + + L+L +   +T+AL
Sbjct: 1010 FSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLAL 1069

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G VLLDG + K   I WLR Q+G+V QEP+LF+ SI 
Sbjct: 1070 VGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIA 1129

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      ++DEI+ AA AAN H FI +LP  Y T VG++GTQLSGGQKQR+AI R
Sbjct: 1130 ENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRR 1189

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P++LLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1190 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1249

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
            G V E G H +L+    G+Y S+V + + A
Sbjct: 1250 GKVKEHGTHQQLLAQ-KGIYFSMVNIQAGA 1278



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 20/150 (13%)

Query: 614 VDANIEQGQVDN---NEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGF 670
           V+ + E G + N   N+K K+++   +      +  +   +LLGTI A+ +G   P+   
Sbjct: 17  VEGDFELGSISNQGRNKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMI 76

Query: 671 LFSAVISMFYK-----------------PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
           +F  +   F                   P     +E   ++  Y GLG   LV   ++  
Sbjct: 77  VFGEMTDKFVNNAGNFSLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVS 136

Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
           F+  A G+ I++IR   F  I+ QE+ WFD
Sbjct: 137 FWTLAAGRQIKKIRQNFFHAILRQEMGWFD 166


>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein
           3)
          Length = 1279

 Score =  492 bits (1266), Expect = e-138
 Identities = 289/804 (35%), Positives = 457/804 (55%), Gaps = 85/804 (10%)

Query: 12  SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
           SS  ++   K  +++    LF ++D  D   M +GTI A+A+G   PLM ++ G++ + F
Sbjct: 26  SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85

Query: 72  GSS---------------NQSEVLNQVSKVSLLFVYLAIGSGI--TSFLQVSCWMVTGER 114
             +               N  ++L +       + Y  +G+G+   +++QVS W +   R
Sbjct: 86  VDTAGNFSFPVNFSLSLLNPGKILEE-EMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR 144

Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
           Q  +IR  +   IL+Q+I +FD    T E+ +R++ D   I E +G+KVG F Q  +TFF
Sbjct: 145 QIRKIRQKFFHAILRQEIGWFDINDTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203

Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
            GF++ FI+GW+L LV++A  P + ++ A  A +++  + +   AYA+AG VA + +G++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263

Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
           RTV +F G+ K +E+Y   ++ A    ++++I++ I MG   L+I+ SY LA WYGS LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323

Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
           I+K Y  G  MTV  +++ G+ S+GQ +P + AFA  + AAY +F+ I   PKID++   
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383

Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
           G   + IKG++E  DVHF YP+R +V+I  G +L V SG T ALVG SG GKST + L++
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443

Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
           R YDP+ G + IDG +++N  + ++RE IG+VSQE                         
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIK 503

Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
                                   + G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563

Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
           D ESE  VQ AL+K    RTTIV+AHRL+T+ +AD IA  + G IVE+G+HSEL M   G
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MKKEG 622

Query: 547 AYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRH 606
            Y +L+ +Q    + +    SE  +  D       MA +  +     R    ++  + ++
Sbjct: 623 VYFKLVNMQTSGSQIQ----SEEFELNDE-KAATRMAPNGWKS----RLFRHSTQKNLKN 673

Query: 607 SQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFP 666
           SQ+  + +D  +E   ++ N  P      S  ++ KLNK E P  ++GT+ A+ NG + P
Sbjct: 674 SQMCQKSLD--VETDGLEANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAIANGGLQP 726

Query: 667 IFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIER 725
            F  +FS +I++F    +  ++++   +SL+++ LG+++   F L+ + FG AG  L  R
Sbjct: 727 AFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRR 786

Query: 726 IRSLTFAKIVHQEIRWFDDPAHSS 749
           +RS+ F  ++ Q++ WFDD  +S+
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNST 810



 Score =  350 bits (897), Expect = 2e-95
 Identities = 215/583 (36%), Positives = 315/583 (53%), Gaps = 53/583 (9%)

Query: 26   VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSK 85
            V F K+    ++ +    ++GT+ A+ANG   P  +++  ++I  FG  + +    + + 
Sbjct: 695  VSFLKVLKL-NKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNI 753

Query: 86   VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEV 144
             SL+F++L I S  T FLQ   +   GE  + R+RS+  K +L+QD+++FD   N TG +
Sbjct: 754  FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGAL 813

Query: 145  ISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAF 204
             +R++ D   +Q A G ++    Q  +    G +I+FI GW+L L+LLA VP I V+G  
Sbjct: 814  STRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIV 873

Query: 205  MAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQ 264
               ++A  A R +     AG +A + + ++RTV S T E+K    Y  K+   Y   VQ+
Sbjct: 874  EMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQK 933

Query: 265  SIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPS 324
            +   GI        ++ SY     +G+ L++        V+ V  A+V G+++LG  S  
Sbjct: 934  AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 993

Query: 325  LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
               +A  K +A  +F   +R+P ID+Y   GL  +  +G+I   +V F YP R +V +  
Sbjct: 994  APDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQ 1053

Query: 385  GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
            G SL V  G T ALVG SG GKSTV+ LLERFYDP AG VL+DG   K L ++W+R Q+G
Sbjct: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLG 1113

Query: 445  LVSQE--------------------------------------------------RQNGT 454
            +VSQE                                                     GT
Sbjct: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173

Query: 455  QLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRL 514
            QLSGGQKQRIAIARA+++ P+ILLLDEATSALD ESE +VQEAL+K    RT IV+AHRL
Sbjct: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1233

Query: 515  TTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEG 557
            +TI +AD I V Q G++ E GTH +L +   G Y  ++ +Q G
Sbjct: 1234 STIQNADLIVVFQNGRVKEHGTHQQL-LAQKGIYFSMVSVQAG 1275



 Score =  310 bits (793), Expect = 2e-83
 Identities = 162/330 (49%), Positives = 222/330 (67%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ GS LV  ++ T      VFFS+ + A SV Q++        A  +A  I
Sbjct: 308  IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 367

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F+I+D+ P IDS S  G   +++ GN+E   V+FSYP+R +++I K L L + S +TVAL
Sbjct: 368  FDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVAL 427

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + L++R YDP+ G + +DG DI+ F +++LR+ +G+V QEP+LF+ +I 
Sbjct: 428  VGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIA 487

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+    T DEI  A   ANA+ FI  LP  +DT VGERG QLSGGQKQRIAIARA
Sbjct: 488  ENICYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE  VQ ALD+    RTT+++AHRL+T+R AD IA  ++G
Sbjct: 547  LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606

Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            ++ E+G H ELM    GVY  LV + ++ S
Sbjct: 607  VIVEQGSHSELMKK-EGVYFKLVNMQTSGS 635



 Score =  309 bits (791), Expect = 3e-83
 Identities = 160/328 (48%), Positives = 225/328 (67%), Gaps = 2/328 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ L+ +    F ++  VF ++   A+++  +S+  PD  KA  SAA +
Sbjct: 948  MYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F + + +P IDS S +G+  +   GNI    V F+YPTR ++ + + L+L +   +T+AL
Sbjct: 1008 FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1067

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G VLLDG + K   + WLR Q+G+V QEPILF+ SI 
Sbjct: 1068 VGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1127

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      ++DEI++AA AAN H FI +LP  Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1128 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1187

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P+ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I V +N
Sbjct: 1188 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1247

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
            G V E G H +L+    G+Y S+V++ +
Sbjct: 1248 GRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1274


>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
          Length = 1277

 Score =  491 bits (1265), Expect = e-138
 Identities = 291/791 (36%), Positives = 449/791 (55%), Gaps = 90/791 (11%)

Query: 26  VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSS----------N 75
           V  + +F +AD LD   M +GT++A+ +G   PL+ L+ G + ++F  S          N
Sbjct: 32  VGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN 91

Query: 76  QSEV--LNQVSKVSL-------LFVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYL 124
           QSE+   + VS  SL        + Y  IG+G  I +++QVS W +   RQ  +IR  + 
Sbjct: 92  QSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFF 151

Query: 125 KTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKG 184
             I+ Q+I +FD   + GE+ +R++ D   I + +G+K+G F Q  +TF  GF+I FI G
Sbjct: 152 HAIMNQEIGWFDVN-DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISG 210

Query: 185 WRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEK 244
           W+L LV+LA  P I ++ A  A V+     +   AYA+AG VA + + ++RTV +F G+K
Sbjct: 211 WKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQK 270

Query: 245 KAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTV 304
           K +E+YN  ++ A    ++++I + I +G   L+++ SY LA WYG+ LV++  Y+ G V
Sbjct: 271 KELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQV 330

Query: 305 MTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGD 364
           +TV  +++ G+ S+G  +P++ AFA  + AAY++F+ I  +P ID++ T G   + I G+
Sbjct: 331 LTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGN 390

Query: 365 IELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEV 424
           +E ++V+F YP+R +V+I  G +L V SG T ALVG SG GKST + LL+R YDP  GEV
Sbjct: 391 LEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEV 450

Query: 425 LIDGVNLKNLQLRWIREQIGLVSQE---------------RQN----------------- 452
            IDG +++ + +R++RE IG+VSQE               R+N                 
Sbjct: 451 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 510

Query: 453 ----------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQE 496
                           G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ 
Sbjct: 511 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 570

Query: 497 ALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
           AL+K    RTTIV+AHRL+T+ +AD IA    G IVE+G H EL M   G Y +L+  Q 
Sbjct: 571 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MKEKGIYFKLVMTQT 629

Query: 557 GEKEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVD 615
              E E G+ + E         +    + S   R S  RSI +      R S  S E VD
Sbjct: 630 RGNEIEPGNNAYESQSDTGASELTSEESKSPLIRRSIRRSIHRRQDQERRLS--SKEDVD 687

Query: 616 ANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAV 675
            ++                 S W++ KLN  E P +++G + A++NG + P+F  +FS +
Sbjct: 688 EDVPM--------------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKI 733

Query: 676 ISMFYKPPEQQRKE--SRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAK 733
           + +F +  + + K+     +SL+++ +G+++ V +  + + FG AG  L +R+R + F  
Sbjct: 734 VGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKS 793

Query: 734 IVHQEIRWFDD 744
           ++ Q+I WFDD
Sbjct: 794 MLRQDISWFDD 804



 Score =  318 bits (815), Expect = 5e-86
 Identities = 198/602 (32%), Positives = 320/602 (52%), Gaps = 59/602 (9%)

Query: 14   STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
            S+++ V++   +V F+++    +  +   +++G + A+ NG   P+  ++  K++  F  
Sbjct: 681  SSKEDVDEDVPMVSFWQILKL-NISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSR 739

Query: 74   SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
             +  E   +   + SLLF+ + + S +T F Q   +   GE  + R+R +  K++L+QDI
Sbjct: 740  DDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDI 799

Query: 133  AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIK--GWRLAL 189
            ++FD   NT G + +R++ D   ++ AMG ++    Q  +    G +++ +   GW+L L
Sbjct: 800  SWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTL 859

Query: 190  VLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEK 249
            +L+  +P IV+ G     +++  A++ +     +G +A + + + RTV S T E+K    
Sbjct: 860  LLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETM 919

Query: 250  YNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVI 309
            Y   ++I Y   ++++   GI       +I+ SY     +G+ LV  +      VM V  
Sbjct: 920  YAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFS 979

Query: 310  ALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRD 369
            A+V G+M+ G TS     +A  K +A  +   I++ P+ID+Y T GL    ++G+++   
Sbjct: 980  AVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNG 1039

Query: 370  VHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGV 429
            V F YP RP++ +  G S  V  G T  LVG SG GKSTV+ LLERFY+P AG V +DG 
Sbjct: 1040 VKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGK 1099

Query: 430  NLKNLQLRWIREQIGLVSQE---------------------------------------- 449
             +K L ++ +R  +G+VSQE                                        
Sbjct: 1100 EIKQLNVQCVR-ALGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFID 1158

Query: 450  ----------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALE 499
                         GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+
Sbjct: 1159 SLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1218

Query: 500  KIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
            K    RT +V+AHRL+TI +AD I V+Q G++ E GTH +L +   G Y  ++  Q G K
Sbjct: 1219 KAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQL-LAQKGIYFSMV--QAGAK 1275

Query: 560  EA 561
             +
Sbjct: 1276 RS 1277



 Score =  305 bits (780), Expect = 6e-82
 Identities = 158/327 (48%), Positives = 220/327 (66%), Gaps = 2/327 (0%)

Query: 746  AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            A+  +Y + A  F+ G+ LV   + +  ++  VFFS+ +   S+   +        A  +
Sbjct: 301  AYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGA 360

Query: 806  AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
            A  IF I+D++P IDS S  G   ++++GN+E ++V F+YP+R +++I K L L + S +
Sbjct: 361  AYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQ 420

Query: 866  TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
            TVALVG SG GKST + LL+R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF 
Sbjct: 421  TVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480

Query: 926  ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
             +I  NI YG+E+  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIA
Sbjct: 481  TTIAENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 539

Query: 986  IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
            IARA+++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA 
Sbjct: 540  IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599

Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLV 1072
               G++ E+G H+ELM    G+Y  LV
Sbjct: 600  FDGGVIVEQGNHEELMKE-KGIYFKLV 625



 Score =  298 bits (763), Expect = 5e-80
 Identities = 159/324 (49%), Positives = 216/324 (66%), Gaps = 3/324 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV     TF  +  VF ++   AM+   +S+  PD  KA  SA+ I
Sbjct: 949  IYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHI 1008

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P+IDS S +G+    + GN++   V F+YPTRP+I + + L+  +   +T+ L
Sbjct: 1009 IGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRL 1068

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFY+P +G V LDG +IK   +  +R  +G+V QEPILF+ SI 
Sbjct: 1069 VGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQEPILFDCSIA 1127

Query: 930  ANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      + +EI+ AA  AN H FI SLP+ Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1128 ENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIAR 1187

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT V++AHRL+TI+ AD I VI+N
Sbjct: 1188 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADLIVVIQN 1247

Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
            G V E G H +L+    G+Y S+V
Sbjct: 1248 GQVKEHGTHQQLLAQ-KGIYFSMV 1270


>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein
           1)
          Length = 1276

 Score =  491 bits (1263), Expect = e-138
 Identities = 286/795 (35%), Positives = 445/795 (55%), Gaps = 89/795 (11%)

Query: 26  VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQS---EVLNQ 82
           V  + +F +AD LD   MI+GT++A+ +G   PL+ L+ G + ++F  +  S    + NQ
Sbjct: 33  VGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQ 92

Query: 83  VSKVSLLFV---------------YLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLK 125
               S L +               Y  IG+G  I +++QVS W +   RQ  +IR  +  
Sbjct: 93  SGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFH 152

Query: 126 TILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGW 185
            I+ Q+I +FD   + GE+ +R++ D   I + +G+K+G F Q  +TF  GF+I FI GW
Sbjct: 153 AIMNQEIGWFDVH-DVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGW 211

Query: 186 RLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKK 245
           +L LV+LA  P I ++ A  A V+     +   AYA+AG VA + + ++RTV +F G++K
Sbjct: 212 KLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQK 271

Query: 246 AIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVM 305
            +E+YN  ++ A    ++++I + I +G   L+++ SY LA WYG+ LV++  Y+ G V+
Sbjct: 272 ELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVL 331

Query: 306 TVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDI 365
           TV  +++ G+ S+G  +P++ AFA  + AA+++F+ I  +P ID++ T G   + I G++
Sbjct: 332 TVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNL 391

Query: 366 ELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVL 425
           E ++VHF YP+R +V+I  G +L V SG T ALVG SG GKST + L++R YDP  G V 
Sbjct: 392 EFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVS 451

Query: 426 IDGVNLKNLQLRWIREQIGLVSQE------------------------------------ 449
           IDG +++ + +R++RE IG+VSQE                                    
Sbjct: 452 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF 511

Query: 450 ------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEA 497
                        + G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ A
Sbjct: 512 IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 571

Query: 498 LEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEG 557
           L+K    RTTIV+AHRL+T+ +AD IA    G IVE+G H EL M   G Y +L+  Q  
Sbjct: 572 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMTQTR 630

Query: 558 EKEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDA 616
             E E G+ +       D   +    + S   R S  RS+ +      R S    E VD 
Sbjct: 631 GNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSM--KEAVDE 688

Query: 617 NIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVI 676
           ++          P +    S WR+  LN  E P +L+G + A++NG + P+F  +FS ++
Sbjct: 689 DV----------PLV----SFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIV 734

Query: 677 SMFYKPP--EQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKI 734
            +F +    E +R+    +SL ++ +GL++ V +  + + FG AG  L +R+R + F  +
Sbjct: 735 GVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSM 794

Query: 735 VHQEIRWFDDPAHSS 749
           + Q+I WFDD  +S+
Sbjct: 795 LRQDISWFDDHKNST 809



 Score =  338 bits (866), Expect = 6e-92
 Identities = 199/600 (33%), Positives = 322/600 (53%), Gaps = 56/600 (9%)

Query: 14   STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
            S ++ V++   +V F+++ +  +  +   +++G + A+ NG   P+  ++  +++  F  
Sbjct: 681  SMKEAVDEDVPLVSFWRILNL-NLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSR 739

Query: 74   SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
             +  E   Q   + SL F+ + + S +T F Q   +   GE  + R+R +  K++L+QDI
Sbjct: 740  DDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDI 799

Query: 133  AFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
            ++FD   N TG + +R++ D   ++ AMG ++    Q  +    G +++ + GW+L L+L
Sbjct: 800  SWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLL 859

Query: 192  LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
            +  +P IV+ G     +++  A++ +     +G +A + + + RT+ S T E+K    Y 
Sbjct: 860  VVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYA 919

Query: 252  SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
              +++ Y   ++++   GI       +++ SY     +G+ LV  +      VM V  A+
Sbjct: 920  QSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAV 979

Query: 312  VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
            V G+M+ G TS     +A  K +A  +   I++ P+ID+Y T GL    ++G+++   V 
Sbjct: 980  VFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQ 1039

Query: 372  FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
            F YP RP++ +  G SL V  G T ALVG SG GKSTV+ LLERFYDP AG V +DG  +
Sbjct: 1040 FNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEI 1099

Query: 432  KNLQLRWIREQIGLVSQE------------------------------------------ 449
            K L ++W+R  +G+VSQE                                          
Sbjct: 1100 KQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSL 1159

Query: 450  --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
                       GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K 
Sbjct: 1160 PDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1219

Query: 502  ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
               RT IV+AHRL+TI +AD I V++ GK+ E GTH +L +   G Y  ++  Q G K +
Sbjct: 1220 REGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQL-LAQKGIYFSMV--QAGAKRS 1276



 Score =  318 bits (814), Expect = 6e-86
 Identities = 165/324 (50%), Positives = 221/324 (67%), Gaps = 2/324 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV  +  TF  +  VF ++   AM+   +S+  PD  KA  SA+ I
Sbjct: 947  MYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHI 1006

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P+IDS S +G+    + GN++   V F+YPTRP+I + + L+L +   +T+AL
Sbjct: 1007 IRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLAL 1066

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G V LDG +IK   + WLR  +G+V QEPILF+ SI 
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIA 1126

Query: 930  ANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG    A + +EI+ AA  AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 ENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1186

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1187 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIEN 1246

Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
            G V E G H +L+    G+Y S+V
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMV 1269



 Score =  311 bits (796), Expect = 8e-84
 Identities = 161/327 (49%), Positives = 221/327 (67%), Gaps = 2/327 (0%)

Query: 746  AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            A+  +Y + A  F+ G+ LV   + +  E+  VFFS+ +   S+   +        A  +
Sbjct: 301  AYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGA 360

Query: 806  AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
            A  IF I+D++P IDS S  G   ++++GN+E ++V+F+YP+R ++QI K L L + S +
Sbjct: 361  AFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQ 420

Query: 866  TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
            TVALVG SG GKST + L++R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF 
Sbjct: 421  TVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480

Query: 926  ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
             +I  NI YG+ED  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIA
Sbjct: 481  TTIAENIRYGRED-VTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIA 539

Query: 986  IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
            IARA+++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA 
Sbjct: 540  IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599

Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLV 1072
               G++ E+G HDELM    G+Y  LV
Sbjct: 600  FDGGVIVEQGNHDELMRE-KGIYFKLV 625


>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein
           2)
          Length = 1276

 Score =  490 bits (1262), Expect = e-138
 Identities = 292/804 (36%), Positives = 454/804 (56%), Gaps = 83/804 (10%)

Query: 11  SSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINA 70
           S S+  +   K   ++    LF ++D  D   M +GT+ A+A+G   PLM ++ G++ + 
Sbjct: 22  SISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDK 81

Query: 71  FGSSNQSEVLNQVSKVSLL--------------FVYLAIGSGI--TSFLQVSCWMVTGER 114
           F  +  +  L     +S+L              + Y  +G G+   +++QVS W +   R
Sbjct: 82  FVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGR 141

Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
           Q  +IR  +   IL+Q++ +FD +  T E+ +R++ D   I E +G+KVG F Q  +TFF
Sbjct: 142 QIKKIRQKFFHAILRQEMGWFDIKGTT-ELNTRLTDDVSKISEGIGDKVGMFFQAIATFF 200

Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
            GF++ FI+GW+L LV++A  P + ++ A  A +++  + +   AYA+AG VA +  G++
Sbjct: 201 AGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAI 260

Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
           RTV +F G+ K +E+Y   ++ A    ++++I++ I MG   L+I+ SY LA WYGS LV
Sbjct: 261 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 320

Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
           I+K Y  G  MTV  +++ G+ S+GQ +P + AFA  + AAY +F+ I   PKID++   
Sbjct: 321 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 380

Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
           G   ++IKG++E  DVHF YP+R +++I  G +L V SG T ALVG SG GKST + LL+
Sbjct: 381 GHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQ 440

Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
           R YDP  G++ IDG +++N  +R +RE IG+VSQE                         
Sbjct: 441 RLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIE 500

Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
                                     G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 501 KAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560

Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
           D ESE  VQ AL+K    RTTIV+AHRL+TI +AD IA  + G IVE+G+HSEL M   G
Sbjct: 561 DTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSEL-MKKEG 619

Query: 547 AYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRH 606
            Y +L+ +Q    +   S   EV+   +    D+   G    +    R+ ++ S  S   
Sbjct: 620 IYFRLVNMQTAGSQIL-SEEFEVELSDEKAAGDVAPNG---WKARIFRNSTKKSLKSPHQ 675

Query: 607 SQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFP 666
           ++L       + E  ++D N  P      S  ++ KLNK E P  ++GT+ A+ NG + P
Sbjct: 676 NRL-------DEETNELDANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAIANGALQP 723

Query: 667 IFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIER 725
            F  + S +I++F    +  ++++   +SLV++GLG+++   F L+ + FG AG  L  R
Sbjct: 724 AFSIILSEMIAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTR 783

Query: 726 IRSLTFAKIVHQEIRWFDDPAHSS 749
           +RS+ F  ++ Q++ WFDD  +S+
Sbjct: 784 LRSMAFKAMLRQDMSWFDDHKNST 807



 Score =  354 bits (909), Expect = 6e-97
 Identities = 216/601 (35%), Positives = 320/601 (52%), Gaps = 53/601 (8%)

Query: 8    HENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKV 67
            H+N        ++     V F K+    ++ +    ++GT+ A+ANG   P  +++L ++
Sbjct: 674  HQNRLDEETNELDANVPPVSFLKVLKL-NKTEWPYFVVGTVCAIANGALQPAFSIILSEM 732

Query: 68   INAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTI 127
            I  FG  + +    + +  SL+F+ L + S  T FLQ   +   GE  + R+RS+  K +
Sbjct: 733  IAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAM 792

Query: 128  LKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWR 186
            L+QD+++FD   N TG + +R++ D   +Q A G K+    Q  +    G +I+FI GW+
Sbjct: 793  LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQ 852

Query: 187  LALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKA 246
            L L+LL+ VP I VAG     ++A  A R +     AG +A + + ++RTV S T E+K 
Sbjct: 853  LTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKF 912

Query: 247  IEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMT 306
               Y  K+   Y   V+++   GI        ++ SY     +GS L++        V+ 
Sbjct: 913  ESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVIL 972

Query: 307  VVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIE 366
            V  A+V G+++LG  S     +A  K +A  +F   +R+P ID+Y   GL  +  +G + 
Sbjct: 973  VFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVT 1032

Query: 367  LRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLI 426
              +V F YP R +V +  G SL V  G T ALVG SG GKSTV+ LLERFYDP AG VL+
Sbjct: 1033 FNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLL 1092

Query: 427  DGVNLKNLQLRWIREQIGLVSQE------------------------------------- 449
            DG   K L ++W+R Q+G+VSQE                                     
Sbjct: 1093 DGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHP 1152

Query: 450  -------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQE 496
                            GTQLSGGQKQRIAIARA+++ P++LLLDEATSALD ESE +VQE
Sbjct: 1153 FIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQE 1212

Query: 497  ALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
            AL+K    RT IV+AHRL+TI +AD I V++ GK+ E GTH +L +   G Y  ++ +Q 
Sbjct: 1213 ALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQL-LAQKGIYFSMVNIQA 1271

Query: 557  G 557
            G
Sbjct: 1272 G 1272



 Score =  307 bits (787), Expect = 9e-83
 Identities = 163/330 (49%), Positives = 219/330 (65%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ GS LV  ++ T      VFFS+ + A SV Q++        A  +A  I
Sbjct: 305  IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 364

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F+I+D+ P IDS S  G   + + GN+E   V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 365  FDIIDNNPKIDSFSERGHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVAL 424

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + LL+R YDP  G++ +DG DI+ F +  LR+ +G+V QEP+LF+ +I 
Sbjct: 425  VGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIA 484

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+    T DEI  A   ANA++FI  LP  +DT VG+RG QLSGGQKQRIAIARA
Sbjct: 485  ENIRYGR-GNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARA 543

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE  VQ ALD+    RTT+++AHRL+TIR AD IA  ++G
Sbjct: 544  LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDG 603

Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            ++ E+G H ELM    G+Y  LV + +  S
Sbjct: 604  VIVEQGSHSELMKK-EGIYFRLVNMQTAGS 632



 Score =  306 bits (785), Expect = 1e-82
 Identities = 158/328 (48%), Positives = 223/328 (67%), Gaps = 2/328 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  GS L+ +    F ++  VF ++ + A+++  +S+  PD  KA  SAA +
Sbjct: 945  MYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYL 1004

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F++ + +P IDS S +G+  +   G++    V F+YPTR ++ + + L+L +   +T+AL
Sbjct: 1005 FSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1064

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G VLLDG + K   + WLR Q+G+V QEPILF+ SI 
Sbjct: 1065 VGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1124

Query: 930  ANIAYGKEDGAT-EDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG        DEI+ AA  AN H FI +LP  Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1125 ENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIAR 1184

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P++LLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1185 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIEN 1244

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
            G V E G H +L+    G+Y S+V + +
Sbjct: 1245 GKVKEHGTHQQLLAQ-KGIYFSMVNIQA 1271



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 37/150 (24%), Positives = 60/150 (39%), Gaps = 20/150 (13%)

Query: 614 VDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELP---VILLGTIAAMVNGVVFPIFGF 670
           +D + E G + N  + K    N I  L      +      + LGT+ A+ +G   P+   
Sbjct: 14  LDGDFELGSISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMI 73

Query: 671 LFSAVISMFY-----------------KPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
           +F  +   F                   P     +E   ++  Y GLG   LV   ++  
Sbjct: 74  VFGEMTDKFVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVS 133

Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
           F+  A G+ I++IR   F  I+ QE+ WFD
Sbjct: 134 FWTLAAGRQIKKIRQKFFHAILRQEMGWFD 163


>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein
           2)
          Length = 1276

 Score =  490 bits (1262), Expect = e-138
 Identities = 285/808 (35%), Positives = 452/808 (55%), Gaps = 92/808 (11%)

Query: 14  STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF-- 71
           S ++   K N  V  + +F +AD LD   M++GT++A+ +G + PL+ L+ G + ++F  
Sbjct: 22  SKKEKKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTK 81

Query: 72  -------GSSNQSEVLN--------QVSKVSLLFVYLAIGSG--ITSFLQVSCWMVTGER 114
                    +NQSE+ N        +    +  + Y  IG+G  I +++QVS W +   R
Sbjct: 82  AETSIWPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGR 141

Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
           Q  +IR  +   I+ Q+I +FD   + GE+ +R++ D   I + +G+K+G F Q  +TF 
Sbjct: 142 QINKIRQKFFHAIMNQEIGWFDVH-DIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFL 200

Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
             F++ FI GW+L LV+LA  P I ++ A  A V+     +   AYA+AG VA + + ++
Sbjct: 201 AAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAI 260

Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
           RTV +F G+ K +E+YN  ++ A    +++++ + I +G   L+++ SY LA WYG+ LV
Sbjct: 261 RTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLV 320

Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
           ++  Y+ G V+TV  +++ G+ S+G  +P++  FA  + AAY++F+ I  +P ID++ T 
Sbjct: 321 LSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQ 380

Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
           G   + + G++E ++VHF YP+R  ++I  G +L V SG T ALVG+SG GKST + LL+
Sbjct: 381 GHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQ 440

Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------RQN------- 452
           R YDP  G V IDG +++ + +R++RE IG+VSQE               R+N       
Sbjct: 441 RLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIE 500

Query: 453 --------------------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
                                     G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 501 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560

Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
           D ESE +VQ AL+K    RTTIV+AHRL+T+ +AD IA    G IVE+G H EL M   G
Sbjct: 561 DTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MKEKG 619

Query: 547 AYSQLIRLQEGEKEAE-GSRS--SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
            Y +L+ +Q    E E GS +  S+ D     L  +     S + R S  RSI  +    
Sbjct: 620 IYCRLVMMQTRGNEVELGSEADGSQSDTIASELTSEEFK--SPSVRKSTCRSICGSQDQE 677

Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
            R S    +  D  +                 S W + KLN  E P +++G + A++NG 
Sbjct: 678 RRVSVKEAQDEDVPLV----------------SFWGILKLNITEWPYLVVGVLCAVINGC 721

Query: 664 VFPIFGFLFSAVISMFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGK 721
           + P+F  +FS +I +F +   P+ +++    +SL ++ +G++  V +  + + FG AG  
Sbjct: 722 MQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEI 781

Query: 722 LIERIRSLTFAKIVHQEIRWFDDPAHSS 749
           L +R+R + F  ++ Q+I WFDD  +S+
Sbjct: 782 LTKRLRYMVFKSMLRQDISWFDDHRNST 809



 Score =  328 bits (840), Expect = 6e-89
 Identities = 192/563 (34%), Positives = 301/563 (53%), Gaps = 53/563 (9%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKV-SLLFVYLAIGSGITS 101
            +++G + A+ NG   P+ +++   +I  F   +  +   Q   + SL F+ + +   +T 
Sbjct: 709  LVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTY 768

Query: 102  FLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMG 160
            F Q   +   GE  + R+R +  K++L+QDI++FD   N TG + +R++ D   ++ AM 
Sbjct: 769  FFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMS 828

Query: 161  EKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAY 220
             ++    Q  +    G +I+ + GW+L L+L+   P I+++G     V++  A++ +   
Sbjct: 829  SRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKEL 888

Query: 221  AEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIF 280
              +G +A + + + RTV S T E+K    Y   ++I Y   ++++   GI       +++
Sbjct: 889  EVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMY 948

Query: 281  CSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFE 340
             SY     +G+ LV  +      VM V  A+V G+++ G  S     +A  K +A  +  
Sbjct: 949  FSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIR 1008

Query: 341  TIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVG 400
             +++ P ID+Y T GL    ++G+++  +V F YP RPD+ +  G SL V  G T ALVG
Sbjct: 1009 IMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVG 1068

Query: 401  QSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE----------- 449
             SG GKSTV+ LLERFYDP AG V +DG  +K L ++W+R  +G+VSQE           
Sbjct: 1069 SSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAEN 1128

Query: 450  ---------------------------------------RQNGTQLSGGQKQRIAIARAI 470
                                                      GTQLSGGQKQRIAIARA+
Sbjct: 1129 IAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARAL 1188

Query: 471  LKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGK 530
            ++ P ILLLDEATSALD ESE +VQEAL+K    RT IV+AHRL+TI +AD I V+Q GK
Sbjct: 1189 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGK 1248

Query: 531  IVERGTHSELTMDPHGAYSQLIR 553
            + E GTH +L +   G Y  +++
Sbjct: 1249 VKEHGTHQQL-LAQKGIYFSMVQ 1270



 Score =  316 bits (809), Expect = 2e-85
 Identities = 166/324 (51%), Positives = 219/324 (67%), Gaps = 2/324 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  G+ LV H+  TF  +  VF ++   A++   +S+  PD  KA  SA+ I
Sbjct: 947  MYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHI 1006

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
              I++  P IDS S  G+    + GN++   V F+YPTRPDI + + L+L +   +T+AL
Sbjct: 1007 IRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1066

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G V LDG +IK   + WLR  +G+V QEPILF+ SI 
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIA 1126

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      ++DEI  AA  AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1186

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P ILLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI+N
Sbjct: 1187 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1246

Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
            G V E G H +L+    G+Y S+V
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMV 1269



 Score =  307 bits (786), Expect = 1e-82
 Identities = 161/331 (48%), Positives = 222/331 (66%), Gaps = 2/331 (0%)

Query: 746  AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            A+  +Y + A  F+ G+ LV   + +  ++  VFFS+     S+   +        A  +
Sbjct: 301  AYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGA 360

Query: 806  AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
            A  IF I+D++P IDS S  G   ++V+GN+E ++V+FSYP+R  I+I K L L + S +
Sbjct: 361  AYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQ 420

Query: 866  TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
            TVALVG+SG GKST + LL+R YDP  G V +DG DI+T  + +LR+ +G+V QEP+LF 
Sbjct: 421  TVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480

Query: 926  ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
             +I  NI YG+E+  T DEI  A   ANA++FI  LP  +DT VGERG QLSGGQKQRIA
Sbjct: 481  TTIAENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 539

Query: 986  IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
            IARA+++NPKILLLDEATSALD ESE +VQ ALD+    RTT+++AHRL+T+R AD IA 
Sbjct: 540  IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599

Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLVALHS 1076
               G++ E+G H+ELM    G+Y  LV + +
Sbjct: 600  FDGGVIVEQGNHEELMKE-KGIYCRLVMMQT 629


>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
           (P-glycoprotein 3)
          Length = 1278

 Score =  483 bits (1242), Expect = e-135
 Identities = 288/803 (35%), Positives = 450/803 (55%), Gaps = 82/803 (10%)

Query: 12  SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
           S+ +++   K N I P   LF ++D  D   M++GT  A+A+G   PLM ++ G++ + F
Sbjct: 24  SNQSREKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKF 82

Query: 72  GSSNQSEVLNQVSKVSLL--------------FVYLAIGSGI--TSFLQVSCWMVTGERQ 115
             +  +  L     +S+L              + Y  +G G+   +++QVS W +   RQ
Sbjct: 83  VDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQ 142

Query: 116 SARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFG 175
             +IR  +   IL+Q++ +FD +  T E+ +R++ D   I E +G+KVG F Q  +TFF 
Sbjct: 143 IRKIRQKFFHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAIATFFA 201

Query: 176 GFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMR 235
           GF++ FI+GW+L LV++A    + ++ A  A +++  + +   AYA+AG VA + +G++R
Sbjct: 202 GFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIR 261

Query: 236 TVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVI 295
           TV +F G+ K +E+Y   ++ A    ++++I++ I MG   L+I+ SY LA WYGS LVI
Sbjct: 262 TVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI 321

Query: 296 AKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSG 355
           +K Y  G  MTV  +++ G+ S+GQ +P + AF   + AAY +F+ I   PKID++   G
Sbjct: 322 SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERG 381

Query: 356 LVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLER 415
              + IKG++E  DVHF YP+R +++I  G +L V SG T ALVG SG GKST + LL+R
Sbjct: 382 HKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQR 441

Query: 416 FYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE-------------------------- 449
            YDP  G + IDG +++N  +R +RE IG+VSQE                          
Sbjct: 442 LYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKK 501

Query: 450 ----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALD 487
                                    G QLSGGQKQRIAIARA+++NPKILLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561

Query: 488 AESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGA 547
            ESE  VQ AL+K    RTTIV+AHRL+T+ +AD IA  + G IVE+G+HSEL +   G 
Sbjct: 562 TESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-IKKEGI 620

Query: 548 YSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHS 607
           Y +L+ +Q    +   S   EV+   +     +   G   +        S  SS +H++ 
Sbjct: 621 YFRLVNMQTSGSQIL-SEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNR 679

Query: 608 QLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPI 667
                    ++E  ++D N  P      S  ++ +LNK E P  ++GT+ A+ NG + P 
Sbjct: 680 --------LDVETNELDANVPPV-----SFLKVLRLNKTEWPYFVVGTLCAIANGALQPA 726

Query: 668 FGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERI 726
           F  + S +I++F    +  ++++   +SLV++GLG+ +   F L+ + FG AG  L  R+
Sbjct: 727 FSIILSEMIAIFGPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRL 786

Query: 727 RSLTFAKIVHQEIRWFDDPAHSS 749
           RS+ F  ++ Q++ WFDD  +S+
Sbjct: 787 RSMAFKAMLRQDMSWFDDHKNST 809



 Score =  352 bits (902), Expect = 4e-96
 Identities = 214/605 (35%), Positives = 321/605 (52%), Gaps = 53/605 (8%)

Query: 4    NTEVHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLL 63
            ++  H+N        ++     V F K+    ++ +    ++GT+ A+ANG   P  +++
Sbjct: 672  SSRAHQNRLDVETNELDANVPPVSFLKVLRL-NKTEWPYFVVGTLCAIANGALQPAFSII 730

Query: 64   LGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLY 123
            L ++I  FG  + +    + +  SL+F+ L + S  T FLQ   +   GE  + R+RS+ 
Sbjct: 731  LSEMIAIFGPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMA 790

Query: 124  LKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFI 182
             K +L+QD+++FD   N TG + +R++ D   +Q A G ++    Q  +    G +I+FI
Sbjct: 791  FKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFI 850

Query: 183  KGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTG 242
             GW+L L+LL+ VP I VAG     ++A  A R +     AG +A + + ++RTV S T 
Sbjct: 851  YGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQ 910

Query: 243  EKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGG 302
            E+K    Y  K+   Y   V+++   GI        ++ SY     +GS L++       
Sbjct: 911  ERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFK 970

Query: 303  TVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIK 362
             V+ V  A+V G+++LG  S     +A  K +A  +F   +R+P ID+Y   G+  +  +
Sbjct: 971  DVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFE 1030

Query: 363  GDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAG 422
            G +   +V F YP R +V +  G SL V  G T ALVG SG GKSTV+ LLERFYDP AG
Sbjct: 1031 GSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG 1090

Query: 423  EVLIDGVNLKNLQLRWIREQIGLVSQE--------------------------------- 449
             VL+DG   K L ++W+R Q+G+VSQE                                 
Sbjct: 1091 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEA 1150

Query: 450  -----------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEH 492
                                GTQLSGGQKQRIAIARA+++ P++LLLDEATSALD ESE 
Sbjct: 1151 NIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEK 1210

Query: 493  IVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLI 552
            +VQEAL+K    RT IV+AHRL+TI +AD I V+  GK+ E GTH +L +   G Y  ++
Sbjct: 1211 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQL-LAQKGIYFSMV 1269

Query: 553  RLQEG 557
             +Q G
Sbjct: 1270 NIQAG 1274



 Score =  307 bits (787), Expect = 9e-83
 Identities = 158/328 (48%), Positives = 224/328 (68%), Gaps = 2/328 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F  GS L+ +    F ++  VF ++ + A+++  +S+  PD  KA  SAA +
Sbjct: 947  MYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYL 1006

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F++ + +P IDS S +G+  +   G++    V F+YPTR ++ + + L+L +   +T+AL
Sbjct: 1007 FSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1066

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKSTV+ LLERFYDP +G VLLDG + K   + WLR Q+G+V QEPILF+ SI 
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1126

Query: 930  ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
             NIAYG      ++DEI+ AA  AN H FI +LP  Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 KNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIAR 1186

Query: 989  AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
            A+++ P++LLLDEATSALD ESE++VQEALD+    RT +++AHRL+TI+ AD I VI N
Sbjct: 1187 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDN 1246

Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
            G V E G H +L+    G+Y S+V + +
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMVNIQA 1273



 Score =  305 bits (781), Expect = 4e-82
 Identities = 161/330 (48%), Positives = 220/330 (65%), Gaps = 2/330 (0%)

Query: 750  LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
            +Y + A  F+ GS LV  ++ T      VFFS+ + A SV Q++        A  +A  I
Sbjct: 305  IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVI 364

Query: 810  FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
            F+I+D+ P IDS S  G   +++ GN+E   V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 365  FDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVAL 424

Query: 870  VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
            VG SG GKST + LL+R YDP  G + +DG DI+ F +  LR+ +G+V QEP+LF+ +I 
Sbjct: 425  VGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIA 484

Query: 930  ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
             NI YG+    T DEI  A   ANA++FI  LP  +DT VG+RG QLSGGQKQRIAIARA
Sbjct: 485  ENIRYGR-GNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARA 543

Query: 990  MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
            +++NPKILLLDEATSALD ESE  VQ ALD+    RTT+++AHRL+T+R AD IA  ++G
Sbjct: 544  LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 603

Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            ++ E+G H EL+    G+Y  LV + ++ S
Sbjct: 604  VIVEQGSHSELIKK-EGIYFRLVNMQTSGS 632



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 37/150 (24%), Positives = 59/150 (38%), Gaps = 20/150 (13%)

Query: 614 VDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELP---VILLGTIAAMVNGVVFPIFGF 670
           +D + E G + N  + K    N I  L      +      +LLGT  A+ +G   P+   
Sbjct: 14  LDGDFELGSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMI 73

Query: 671 LFSAVISMFY-----------------KPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
           +F  +   F                   P     +E   ++  Y GLG   L+   ++  
Sbjct: 74  VFGEMTDKFVDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVS 133

Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
           F+  A G+ I +IR   F  I+ QE+ WFD
Sbjct: 134 FWTLAAGRQIRKIRQKFFHAILRQEMGWFD 163


>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
           sub-family B, member 11)
          Length = 1321

 Score =  459 bits (1182), Expect = e-128
 Identities = 284/839 (33%), Positives = 451/839 (52%), Gaps = 99/839 (11%)

Query: 3   DNTEVHENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMT 61
           ++ + + N   S  Q   K + + V F++LF F+   D+ LM +G++ A  +G A P + 
Sbjct: 21  ESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVL 80

Query: 62  LLLGKVINAF--------------------------GSSNQS----------EVLNQVSK 85
           L+ G + + F                           S NQ+           + +++ K
Sbjct: 81  LIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIK 140

Query: 86  VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVI 145
            +  +  +A+   IT ++Q+  W++   RQ  ++R  Y + I++ +I +FD  +  GE+ 
Sbjct: 141 FASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS-VGELN 199

Query: 146 SRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFM 205
           +R S D   I +A+ +++  F+Q  ++   GF++ F +GW+L LV+++  P I +  A +
Sbjct: 200 TRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATI 259

Query: 206 AMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQS 265
            + ++K       AYA+AG VA++ + SMRTVA+F GEK+ +E+Y   +  A    +++ 
Sbjct: 260 GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKG 319

Query: 266 IASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPS 324
           I  G   G +  +IF  Y +A WYGS LV+ +G Y  GT++ + ++++ G+++LG  SP 
Sbjct: 320 IVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPC 379

Query: 325 LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
           L AFA G+AAA  +FETI RKP ID     G  L+ IKG+IE  +V F YP+RP+V+I  
Sbjct: 380 LEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILN 439

Query: 385 GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
             ++ +  G  TALVG SG+GKST + L++RFYDP  G V +DG ++++L ++W+R+QIG
Sbjct: 440 DLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIG 499

Query: 445 LVSQE------------------------------------------------RQNGTQL 456
           +V QE                                                 + G Q+
Sbjct: 500 IVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQM 559

Query: 457 SGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTT 516
           SGGQKQR+AIARA+++NPKILLLD ATSALD ESE +VQE L KI    T I VAHRL+T
Sbjct: 560 SGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLST 619

Query: 517 IIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNL 576
           +  ADTI   + G  VERGTH EL ++  G Y  L+ LQ    +A      + D   D++
Sbjct: 620 VRAADTIIGFEHGTAVERGTHEEL-LERKGVYFTLVTLQSQGNQALNEEDIK-DATEDDM 677

Query: 577 NIDIHMAGS---STQRISFVRSISQTSSMSHRHSQLSGEIVD--ANIEQGQVDNNEKPKM 631
                  GS   S +     RS SQ S + H        +VD  +  E+ + D +   + 
Sbjct: 678 LARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIPVQE 734

Query: 632 SMKNS-IWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKP-PEQQRKE 689
            ++ + + R+ K + PE P +L+G++ A VNG V P++ FLFS ++  F  P  E+QR +
Sbjct: 735 EVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQ 794

Query: 690 SRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
                L++V +G V+L    L+ Y F  +G  L +R+R   F  ++ Q+I WFDD  +S
Sbjct: 795 INGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNS 853



 Score =  332 bits (850), Expect = 4e-90
 Identities = 201/603 (33%), Positives = 320/603 (52%), Gaps = 53/603 (8%)

Query: 1    MADNTEVHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLM 60
            + D+   +E         V +  +  P  ++  F+   +   M++G++ A  NG  +PL 
Sbjct: 714  VVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAP-EWPYMLVGSVGAAVNGTVTPLY 772

Query: 61   TLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIR 120
              L  +++  F   ++ E  +Q++ V LLFV +   S  T FLQ   +  +GE  + R+R
Sbjct: 773  AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832

Query: 121  SLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVI 179
                + +L QDIA+FD   N+ G + +R++ D   +Q A G ++G  +   +      +I
Sbjct: 833  KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892

Query: 180  AFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVAS 239
            AF   W+L+LV+L   P + ++GA    ++   A R + A    G + N+ + ++RTVA 
Sbjct: 893  AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAG 952

Query: 240  FTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGY 299
               E++ IE   ++++  +   +Q++   G        I+F +   +  YG  L+  +G 
Sbjct: 953  IGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGL 1012

Query: 300  NGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLE 359
            +   V  V+ A+V  + +LG+      ++A  K +A + F+ + R+P I  Y+T+G   +
Sbjct: 1013 HFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD 1072

Query: 360  DIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDP 419
            + +G I+  D  F YP+RPD ++  G S+ +  G T A VG SG GKST I LLERFYDP
Sbjct: 1073 NFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDP 1132

Query: 420  NAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------------ 449
            + G+V+IDG + K + ++++R  IG+VSQE                              
Sbjct: 1133 DQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAA 1192

Query: 450  --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
                                   G+QLS G+KQRIAIARAI+++PKILLLDEATSALD E
Sbjct: 1193 KQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTE 1252

Query: 490  SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
            SE  VQ AL+K    RT IV+AHRL+TI +AD IAV+ QG ++E+GTH EL M   GAY 
Sbjct: 1253 SEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL-MAQKGAYY 1311

Query: 550  QLI 552
            +L+
Sbjct: 1312 KLV 1314



 Score =  291 bits (744), Expect = 8e-78
 Identities = 157/331 (47%), Positives = 214/331 (64%), Gaps = 9/331 (2%)

Query: 750  LYCTNAFIFYIGSILV----HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            ++   A  F+ GS LV     +   T V+IF    S+ + A+++  +S           +
Sbjct: 333  IFLCYAVAFWYGSTLVLDEGEYTPGTLVQIF---LSVIVGALNLGNASPCLEAFATGRAA 389

Query: 806  AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
            A SIF  +D KP ID  S DG   + + G IE  +V F YP+RP+++I  DL + I   +
Sbjct: 390  ATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGE 449

Query: 866  TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
              ALVG SG+GKST + L++RFYDP  G V +DG DI++  I WLR Q+G+V QEP+LF+
Sbjct: 450  MTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFS 509

Query: 926  ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
             +I  NI YG+ED AT ++I+ AA  ANA+NFI  LP  +DT VGE G Q+SGGQKQR+A
Sbjct: 510  TTIAENIRYGRED-ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVA 568

Query: 986  IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
            IARA+++NPKILLLD ATSALD ESE +VQE L ++    T + VAHRL+T+R ADTI  
Sbjct: 569  IARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIG 628

Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLVALHS 1076
             ++G   E+G H+EL+    GVY +LV L S
Sbjct: 629  FEHGTAVERGTHEELLER-KGVYFTLVTLQS 658



 Score =  279 bits (714), Expect = 3e-74
 Identities = 153/337 (45%), Positives = 214/337 (63%), Gaps = 6/337 (1%)

Query: 746  AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            A   ++  N+  +  G  L+ +    F  +FRV  ++ ++A ++ ++ +  P   KA  S
Sbjct: 988  AQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKIS 1047

Query: 806  AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
            AA  F +LD +P I   +  G   +   G I+     F+YP+RPD Q+   L++SI   +
Sbjct: 1048 AARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQ 1107

Query: 866  TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
            T+A VG SG GKST I LLERFYDP+ G+V++DG D K   + +LR  +G+V QEP+LF 
Sbjct: 1108 TLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFA 1167

Query: 926  ESIRANIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQ 982
             SI  NI YG  D   E   + +IAAA  A  H+F+ SLP+ Y+T+VG +G+QLS G+KQ
Sbjct: 1168 CSIMDNIKYG--DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQ 1225

Query: 983  RIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADT 1042
            RIAIARA++++PKILLLDEATSALD ESE+ VQ ALD+    RT +++AHRL+TI+ AD 
Sbjct: 1226 RIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADI 1285

Query: 1043 IAVIKNGMVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
            IAV+  G+V EKG H+ELM    G Y  LV   S  S
Sbjct: 1286 IAVMAQGVVIEKGTHEELMAQ-KGAYYKLVTTGSPIS 1321


>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
           sub-family B, member 11) (Sister of P-glycoprotein)
          Length = 1321

 Score =  447 bits (1151), Expect = e-125
 Identities = 287/839 (34%), Positives = 430/839 (51%), Gaps = 117/839 (13%)

Query: 8   HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
           H N   S  Q   K     V F++LF F+   D  LM +G++ A+ +G A P M ++ G 
Sbjct: 26  HNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGI 85

Query: 67  VINAF--------------------------GSSNQS----------EVLNQVSKVSLLF 90
           + + F                           S NQ+          ++ ++V K S ++
Sbjct: 86  LTDIFVEYDIERQELSIPGKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIY 145

Query: 91  VYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
             + +   I  + Q+  W++TG RQ  ++R  Y + I++ +I +FD  T+ GE+ SR S 
Sbjct: 146 AGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDC-TSVGELNSRFSD 204

Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
           D   I EA+ +++  FLQ  ST   G ++ F +GW+L LV+LA  P I +  A + + +A
Sbjct: 205 DINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVA 264

Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
           K       AYA+AG++A++ + S+RTVA+F GE K +E+Y   +  A    + + +  G 
Sbjct: 265 KFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGF 324

Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
             G +  +IF  Y LA WYGS+LV+ +G Y  GT++ + + ++  +M++G  S  L  F+
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFS 384

Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
            G +AA  +F+TI R+P +D     G  L+ IKG+IE  +V F YP+RP+V+I    S+ 
Sbjct: 385 TGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMV 444

Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
           +  G TTA VG SG+GKST + L++RFYDP  G V +DG ++++L +RW+R+QIG+V QE
Sbjct: 445 IKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQE 504

Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
                                                            + G Q+SGGQK
Sbjct: 505 PVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQK 564

Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
           QR+AIARA+++ PKILLLD ATSALD ESE  VQ AL KI    T I VAHRL+T+  AD
Sbjct: 565 QRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSAD 624

Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQ------------EGEKEAEG---SRS 566
            I   + G  VERGTH EL ++  G Y  L+ LQ            +G+   EG    R+
Sbjct: 625 VIIGFEHGTAVERGTHEEL-LERKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERT 683

Query: 567 SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNN 626
                + D+L   I             RS SQ S +SH      G+    +  + + DN+
Sbjct: 684 FSRGSYQDSLRASIRQ-----------RSKSQLSHLSHEPPLAIGD--HKSSYEDRKDND 730

Query: 627 EKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMF-YKPPEQ 685
              +      + R+ K N  E P IL+G + A +NG V PI+  LFS ++  F     EQ
Sbjct: 731 VLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQ 790

Query: 686 QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDD 744
           QR E     L +V LG V+L    L+ Y F  +G  L +R+R   F  ++ Q+I WFDD
Sbjct: 791 QRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDD 849



 Score =  317 bits (811), Expect = 1e-85
 Identities = 189/561 (33%), Positives = 304/561 (53%), Gaps = 52/561 (9%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
            +++G + A  NG  +P+ +LL  +++  F   ++ +  +++  + L FV L   S  T F
Sbjct: 755  ILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQF 814

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDT-ETNTGEVISRMSGDTILIQEAMGE 161
            LQ   +  +GE  + R+R    K +L+QDI +FD  + N G + +R++ D   +Q A G 
Sbjct: 815  LQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGS 874

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            +VG  +   +  F   +IAF+  W+L+LV+    P + ++GA    ++   A + +    
Sbjct: 875  QVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILE 934

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
            +AG + N+ + ++RTVA    E + I+ +  +++ +Y   ++++   G+       I F 
Sbjct: 935  KAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFL 994

Query: 282  SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
            +   A  YG  L++ +  N   V  VV ++   + ++G+T     ++A  K +A + F+ 
Sbjct: 995  ANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQL 1054

Query: 342  IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
            + RKP ID Y  +G   ++ +G I+  D  F YP+RPD+++  G S+ V  G T A VG 
Sbjct: 1055 LDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGS 1114

Query: 402  SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
            SG GKST I LLERFYDP+ G V+IDG + K + ++++R  IG+VSQE            
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNI 1174

Query: 450  ---------------------------------RQNGTQLSGGQ-----KQRIAIARAIL 471
                                              +    + G Q     KQRIAIARAI+
Sbjct: 1175 KYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIV 1234

Query: 472  KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
            ++PKILLLDEATSALD ESE  VQ AL+K    RT IV+AHRL+TI ++D IAV+ QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVV 1294

Query: 532  VERGTHSELTMDPHGAYSQLI 552
            +E+GTH +L MD  GAY +L+
Sbjct: 1295 IEKGTHKKL-MDQKGAYYKLV 1314



 Score =  283 bits (723), Expect = 2e-75
 Identities = 154/325 (47%), Positives = 211/325 (64%), Gaps = 6/325 (1%)

Query: 751  YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
            +  N+  +  G  L+ +    F  +FRV  S+ M+A +V ++ +  P   KA  SAA  F
Sbjct: 993  FLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFF 1052

Query: 811  NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
             +LD KP ID  S  G   +   G I+     F+YP+RPDIQ+   L++S+   +T+A V
Sbjct: 1053 QLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFV 1112

Query: 871  GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
            G SG GKST I LLERFYDP+ G V++DG D K   + +LR  +G+V QEP+LF+ SI  
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMD 1172

Query: 931  NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
            NI YG  D   E   +  IAAA  A  H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIA 1230

Query: 988  RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
            RA++++PKILLLDEATSALD ESE+ VQ ALD+    RT +++AHRL+TI+ +D IAV+ 
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMS 1290

Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
             G+V EKG H +LM+   G Y  LV
Sbjct: 1291 QGVVIEKGTHKKLMDQ-KGAYYKLV 1314



 Score =  280 bits (717), Expect = 1e-74
 Identities = 149/323 (46%), Positives = 212/323 (65%), Gaps = 3/323 (0%)

Query: 755  AFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL 813
            A  F+ GS LV    + T   + ++F  + + AM++  +S+     +    +A+SIF  +
Sbjct: 338  ALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTI 397

Query: 814  DSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGES 873
            D +P +D  S DG   + + G IE  +V F YP+RP+++I  +L++ I   +T A VG S
Sbjct: 398  DRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSS 457

Query: 874  GSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIA 933
            G+GKST + L++RFYDP  G V LDG DI++  I WLR Q+G+V QEP+LF+ +I  NI 
Sbjct: 458  GAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIR 517

Query: 934  YGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
             G+E+ AT ++I+ AA  ANA+NFI +LP  +DT VGE G Q+SGGQKQR+AIARA+++ 
Sbjct: 518  LGREE-ATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRK 576

Query: 994  PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
            PKILLLD ATSALD ESE  VQ AL+++    T + VAHRL+T+R AD I   ++G   E
Sbjct: 577  PKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVE 636

Query: 1054 KGRHDELMNNTHGVYASLVALHS 1076
            +G H+EL+    GVY  LV L S
Sbjct: 637  RGTHEELLER-KGVYFMLVTLQS 658


>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
           sub-family B, member 11) (Sister of P-glycoprotein)
          Length = 1321

 Score =  444 bits (1141), Expect = e-124
 Identities = 283/839 (33%), Positives = 433/839 (50%), Gaps = 117/839 (13%)

Query: 8   HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
           H N   S  Q   K   I V F++LF F+   D+ LM++G + A+ +G A P + ++ G 
Sbjct: 26  HNNDKKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGI 85

Query: 67  VINAF--------------------------GSSNQS----------EVLNQVSKVSLLF 90
           + + F                           S +Q+          ++ +++ K S ++
Sbjct: 86  MTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIY 145

Query: 91  VYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
             + +   I  + Q+  W++TG RQ  R+R +Y + I++ +I +FD  T+ GE+ SR + 
Sbjct: 146 AGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDC-TSVGELNSRFAD 204

Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
           D   I +A+ +++  FLQ  ST   G ++ F +GW+L LV+LA  P I +  A + + +A
Sbjct: 205 DIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIA 264

Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
           K       AYA+AG++A++ + S+RTVA+F GE K +E+Y   +  A    + + +  G 
Sbjct: 265 KFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGF 324

Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVI-AKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
             G +  +IF  Y LA WYGS LV+  + Y  GT++ + + ++  +M++G  S  L  F+
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFS 384

Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
            G +AA  +F+TI R+P ID     G  L+ IKG+IE  +V F YP+RPDV+I    S+ 
Sbjct: 385 TGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMV 444

Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
           +  G TTALVG SG+GKST + L++RFYDP  G V +DG ++++L +RW+R+QIG+V QE
Sbjct: 445 IKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQE 504

Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
                                                            + G Q+SGGQK
Sbjct: 505 PVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQK 564

Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
           QR+AIARA+++NPKILLLD ATSALD ESE  VQEAL KI    T I VAHRL+T+  AD
Sbjct: 565 QRVAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAAD 624

Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE------------GEKEAEG---SRS 566
            I   + G  VERGTH EL ++  G Y  L+ LQ             G+   EG    R+
Sbjct: 625 VIIGFEHGVAVERGTHEEL-LERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERT 683

Query: 567 SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNN 626
                + D+L   I     S  ++S +      +   H+ S    +  D  +E+ +    
Sbjct: 684 FSRGSYRDSLRASIRQRSKS--QLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVE---- 737

Query: 627 EKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMF-YKPPEQ 685
                     + R+ K N PE   IL+G+++A +NG V PI+  LFS ++  F     EQ
Sbjct: 738 -------PAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQ 790

Query: 686 QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDD 744
           QR E     L +V LG V++    L+ Y F  +G  L +R+R   F  ++ Q+I WFDD
Sbjct: 791 QRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDD 849



 Score =  313 bits (801), Expect = 2e-84
 Identities = 188/561 (33%), Positives = 301/561 (53%), Gaps = 52/561 (9%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
            +++G++SA  NG  +P+ +LL  +++  F   ++ +  +++  + L FV L   S  T F
Sbjct: 755  ILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQF 814

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDT-ETNTGEVISRMSGDTILIQEAMGE 161
            LQ   +  +GE  + R+R    K +L QDI +FD    N G + +R++ D   +Q A G 
Sbjct: 815  LQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGS 874

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            +VG  +   +      +IAF   W+L+L++    P + ++GA    ++   A + + A  
Sbjct: 875  QVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALE 934

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
            +AG + ++ + ++RTVA    E + I+ +  +++ +Y   V+++   G+       I F 
Sbjct: 935  KAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFL 994

Query: 282  SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
            +   A  YG  L+  +G     V  VV ++   + ++G+T     ++A  K +A + F+ 
Sbjct: 995  ANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQL 1054

Query: 342  IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
            + RKP I+ Y  +G   ++ +G I+  D  F YP+RPD+++  G S+ V  G T A VG 
Sbjct: 1055 LDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGS 1114

Query: 402  SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
            SG GKST I LLERFYDP+ G V+IDG + K + ++++R  IG+VSQE            
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNI 1174

Query: 450  ---------------------------------RQNGTQLSGGQ-----KQRIAIARAIL 471
                                              +    + G Q     KQRIAIARAI+
Sbjct: 1175 KYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIV 1234

Query: 472  KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
            ++PKILLLDEATSALD ESE  VQ AL+K    RT IV+AHRL+TI ++D IAVV QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVV 1294

Query: 532  VERGTHSELTMDPHGAYSQLI 552
            +E+GTH +L M   GAY +L+
Sbjct: 1295 IEKGTHEKL-MAQKGAYYKLV 1314



 Score =  293 bits (750), Expect = 2e-78
 Identities = 154/323 (47%), Positives = 216/323 (66%), Gaps = 3/323 (0%)

Query: 755  AFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL 813
            A  F+ GS LV    + T   + ++F  + + AM++  +S+     +    +A +IF  +
Sbjct: 338  ALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTI 397

Query: 814  DSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGES 873
            D +P ID  S DG   + + G IE  +V F YP+RPD++I  +L++ I   +T ALVG S
Sbjct: 398  DRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSS 457

Query: 874  GSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIA 933
            G+GKST + L++RFYDP  G V LDG DI++  I WLR Q+G+V QEP+LF+ +I  NI 
Sbjct: 458  GAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIR 517

Query: 934  YGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
            +G+ED AT ++I+ AA  ANA+NFI +LP  +DT VGE G Q+SGGQKQR+AIARA+++N
Sbjct: 518  FGRED-ATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRN 576

Query: 994  PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
            PKILLLD ATSALD ESE  VQEAL+++    T + VAHRL+T+R AD I   ++G+  E
Sbjct: 577  PKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVE 636

Query: 1054 KGRHDELMNNTHGVYASLVALHS 1076
            +G H+EL+    GVY  LV L S
Sbjct: 637  RGTHEELLER-KGVYFMLVTLQS 658



 Score =  281 bits (718), Expect = 9e-75
 Identities = 153/325 (47%), Positives = 211/325 (64%), Gaps = 6/325 (1%)

Query: 751  YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
            +  N+  +  G  L+ +    F  +FRV  S+ ++A +V ++ +  P   KA  SAA  F
Sbjct: 993  FLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFF 1052

Query: 811  NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
             +LD KP I+  S  G   +   G I+     F+YP+RPDIQ+   L++S+   +T+A V
Sbjct: 1053 QLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFV 1112

Query: 871  GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
            G SG GKST I LLERFYDP+ G V++DG D K   I +LR  +G+V QEP+LF+ SI  
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMD 1172

Query: 931  NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
            NI YG  D   E   +  IAAA  A  H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIA 1230

Query: 988  RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
            RA++++PKILLLDEATSALD ESE+ VQ ALD+    RT +++AHRL+TI+ +D IAV+ 
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVS 1290

Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
             G+V EKG H++LM    G Y  LV
Sbjct: 1291 QGVVIEKGTHEKLMAQ-KGAYYKLV 1314


>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
           sub-family B, member 11) (Sister of P-glycoprotein)
          Length = 1321

 Score =  432 bits (1110), Expect = e-120
 Identities = 278/832 (33%), Positives = 433/832 (51%), Gaps = 95/832 (11%)

Query: 8   HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
           + N   S  Q   K++ + + F++LF F+   D+ LM +G++ A  +G A P + L+ G 
Sbjct: 26  YNNEKKSRLQDKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGT 85

Query: 67  VINAF-------------------------GSSNQSEVLN---------QVSKVSLLFVY 92
           + + F                          SS    V N         +   +     Y
Sbjct: 86  MTDVFIDYDTELQELKIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDIESEMIRFAGYY 145

Query: 93  LAIGSGI--TSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
             IG  +  T ++Q+  W +    Q  ++R  Y + I++  I + D  +  G++ +  S 
Sbjct: 146 AGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNS-VGKLNTPFSV 204

Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
           D   I ++  +++  F+Q  ++   GF++ F + W+L LV+++  P I +  A + + ++
Sbjct: 205 DFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVS 264

Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
           K       AYA+AG+VA++ + SMRTVA+F GEKK +E+Y   +  A    +++ I  G 
Sbjct: 265 KFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGF 324

Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
             G +  +IF  Y LA WYGSKLV+ +G Y+ G ++ + ++++ G+++LG  SP L AFA
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFA 384

Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
           AG+AAA  +FETI RKP ID     G  LE IKG+IE  +V F YP+RP+V+I    S+ 
Sbjct: 385 AGRAAASSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMV 444

Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
           +  G  TALVG SG+GKST + L+ RFY P  G V ++  ++++  ++W+R QIG+V QE
Sbjct: 445 IKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQE 504

Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
                                                            + G Q+SGGQK
Sbjct: 505 PVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQK 564

Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
           QR+AIARA+++NPKILLLD ATSALD ESE +VQEAL K     T + VAHR  TI  AD
Sbjct: 565 QRVAIARALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTAD 624

Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIH 581
            I   + G  VERGT  EL ++  G Y  L+ LQ    + +    +E D   D++     
Sbjct: 625 VIIGCEHGAAVERGTEEEL-LERKGVYFALVTLQSQRNQGD-QEENEKDATEDDIPEKTF 682

Query: 582 MAGS---STQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMK-NSI 637
             G+   S +     RS SQ S ++H    ++ E   +  E+ + D +   +  ++  S+
Sbjct: 683 SRGNYQDSLRASLRQRSKSQLSYLAH-EPPMAVEDHKSTHEEDRKDKDLPAQEDIEPASV 741

Query: 638 WRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKP-PEQQRKESRFWSLV 696
            R+ KLN PE P +LLG++ A VNG V P++ FLFS ++  F  P  E+QR +     L+
Sbjct: 742 RRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLL 801

Query: 697 YVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
           +V LG V+     L+ Y F  +G  L +R+R   F  ++ Q+I WFDD  +S
Sbjct: 802 FVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNS 853



 Score =  328 bits (842), Expect = 4e-89
 Identities = 192/561 (34%), Positives = 309/561 (54%), Gaps = 52/561 (9%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
            M++G++ A  NG  +PL   L  +++  F   ++ E  +Q++ + LLFV L   S  T F
Sbjct: 755  MLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQF 814

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
            LQ   +  +GE  + R+R    + +L QDI +FD   N+ G + +R++ D   +Q A G 
Sbjct: 815  LQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGS 874

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            ++G  +   +      +IAF+  W+L L ++   P + ++GA    ++   A R + A  
Sbjct: 875  QIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALE 934

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
            +AG + ++ + ++RTVA    E+K IE + ++++  Y   ++++   G+  G    I F 
Sbjct: 935  KAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFI 994

Query: 282  SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
            +   +  YG  L+  +G +   V  V+ A+V  + +LG+ S    ++A  K +A + F+ 
Sbjct: 995  ANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQL 1054

Query: 342  IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
            + R+P I+ Y ++G   ++ +G I+  D  F YP+RPD+++  G S+ +    T A VG 
Sbjct: 1055 LDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGS 1114

Query: 402  SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
            SG GKST I LLERFYDP+ G+V+IDG + + + ++++R  IG+VSQE            
Sbjct: 1115 SGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNI 1174

Query: 450  --------------------------------------RQNGTQLSGGQKQRIAIARAIL 471
                                                     G+QLS G+KQRIAIARAI+
Sbjct: 1175 KYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234

Query: 472  KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
            ++PKILLLDEATSALD ESE  VQ AL+K    RT IV+AHRL+TI ++D IAV+ QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMV 1294

Query: 532  VERGTHSELTMDPHGAYSQLI 552
            +E+GTH EL M   GAY +L+
Sbjct: 1295 IEKGTHEEL-MVQKGAYYKLV 1314



 Score =  284 bits (727), Expect = 8e-76
 Identities = 155/332 (46%), Positives = 217/332 (64%), Gaps = 6/332 (1%)

Query: 751  YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
            +  N+  +  G  L+ +    F  +FRV  ++ ++A ++ ++S+  P   KA  SAA  F
Sbjct: 993  FIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFF 1052

Query: 811  NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
             +LD +P I+  S+ G   +   G I+     F+YP+RPDIQ+   L++S+   +T+A V
Sbjct: 1053 QLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFV 1112

Query: 871  GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
            G SG GKST I LLERFYDP+ G+V++DG D +   I +LR  +G+V QEP+LF  SI+ 
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKD 1172

Query: 931  NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
            NI YG  D   E   + IIAAA  A  H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIA 1230

Query: 988  RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
            RA++++PKILLLDEATSALD ESE+ VQ ALD+    RT +++AHRL+TI+ +D IAV+ 
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMS 1290

Query: 1048 NGMVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
             GMV EKG H+ELM    G Y  LV   S  S
Sbjct: 1291 QGMVIEKGTHEELMVQ-KGAYYKLVTTGSPIS 1321



 Score =  273 bits (697), Expect = 2e-72
 Identities = 174/446 (39%), Positives = 247/446 (55%), Gaps = 29/446 (6%)

Query: 656  IAAMVNGVVFPIFGFLFSAVISMFYKPPEQQRKESRFWSL--VYVGLGLVTLVVFPLKNY 713
            +A  + G+  PIFGFL     S ++K        S    L    +GL +     + LK Y
Sbjct: 217  LAIFIQGMTSPIFGFLVG--FSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAY 274

Query: 714  F-FGTAGGKLIERIRSLTFAKIVHQEI-----------RW----------FDDPAHSSLY 751
               G+   ++I  +R++       +E+           RW          F       ++
Sbjct: 275  AKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIF 334

Query: 752  CTNAFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
               A  F+ GS LV    + +   + ++F S+ + A+++  +S           +A+SIF
Sbjct: 335  FCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIF 394

Query: 811  NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
              +D KP ID  S DG   E + G IE  +V F YP+RP+++I  +L++ I   +  ALV
Sbjct: 395  ETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALV 454

Query: 871  GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
            G SG+GKST + L+ RFY P  G V ++  DI++  I WLR Q+G+V QEP+LF  +I  
Sbjct: 455  GPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAE 514

Query: 931  NIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAM 990
             I YG+ED AT +++I AA  ANA+NFI  LP  +DT VGE G Q+SGGQKQR+AIARA+
Sbjct: 515  KIRYGRED-ATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573

Query: 991  LKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGM 1050
            ++NPKILLLD ATSALD ESE +VQEAL +     T V VAHR  TIR AD I   ++G 
Sbjct: 574  IRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGA 633

Query: 1051 VAEKGRHDELMNNTHGVYASLVALHS 1076
              E+G  +EL+    GVY +LV L S
Sbjct: 634  AVERGTEEELLER-KGVYFALVTLQS 658


>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein
           A)
          Length = 1321

 Score =  407 bits (1046), Expect = e-113
 Identities = 260/811 (32%), Positives = 420/811 (51%), Gaps = 89/811 (10%)

Query: 16  QQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF---- 71
           ++ VNK +  +P  +L+ +   L+  L+ IGT+ A+  G   PLM++L GKV  AF    
Sbjct: 54  EEVVNKVS--IP--QLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQ 109

Query: 72  ------GSS--------NQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSA 117
                 GS+         +++  + V  V   +  + +G      + V+C++   E+ + 
Sbjct: 110 IVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNN 169

Query: 118 RIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGF 177
           R+R  ++K+IL+Q+I++FDT  ++G + +++  +   ++E  G+K+G   Q  S F  GF
Sbjct: 170 RLRREFVKSILRQEISWFDTN-HSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGF 228

Query: 178 VIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTV 237
           ++AF   W+L LV+LA  P   + G  +A  M+  AIR  + YA+AG V  +T+ S+RTV
Sbjct: 229 IVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTV 288

Query: 238 ASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAK 297
            S  G +  +E+Y++ ++ A  A V + +  GI  G +    F S+ LA + G   V   
Sbjct: 289 VSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDG 348

Query: 298 GYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLV 357
             N G ++T   +++ GSM+LG   P L      + AA  ++E + RKP ID+   +G  
Sbjct: 349 SLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRK 408

Query: 358 LEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFY 417
              IKGDI + +VHF YP+RPDV I  G +L V +G T ALVG SG GKST+ISLL R+Y
Sbjct: 409 DMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYY 468

Query: 418 DPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------------------- 449
           D   G++ IDGV+++++ L ++R+ + +VSQE                            
Sbjct: 469 DVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAAC 528

Query: 450 --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
                                  GTQLSGGQKQRIAIARA+++NPKILLLDEATSALDAE
Sbjct: 529 KMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAE 588

Query: 490 SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
           SE IVQ+AL+K    RTTI++AHRL+TI +AD I   + G++VE G H  L M   G Y 
Sbjct: 589 SEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRAL-MAQQGLYY 647

Query: 550 QLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQ-----------RISFVRSISQ 598
            L+  Q      + +   +  +            G S Q           R S + SI+ 
Sbjct: 648 DLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITN 707

Query: 599 TSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAA 658
              +  +  ++ G+   + ++Q   +NN     + K +++ +    +P    + +G   A
Sbjct: 708 GPVIDEKEERI-GKDALSRLKQELEENN-----AQKTNLFEILYHARPHALSLFIGMSTA 761

Query: 659 MVNGVVFPIFGFLFSAVISMFYKPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTA 718
            + G ++P +   F++ +++F   P     +  FW+L+++ L     +   L  +F G A
Sbjct: 762 TIGGFIYPTYSVFFTSFMNVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIA 821

Query: 719 GGKLIERIRSLTFAKIVHQEIRWFDDPAHSS 749
              L   +R+  F  ++ Q I +FD P ++S
Sbjct: 822 SESLTRDLRNKLFRNVLSQHIGFFDSPQNAS 852



 Score =  305 bits (782), Expect = 3e-82
 Identities = 163/325 (50%), Positives = 222/325 (68%), Gaps = 2/325 (0%)

Query: 748  SSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAA 807
            +S + + A  FYIG   VH     F ++   F S+ M +M++  +         A  +A+
Sbjct: 328  ASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAAS 387

Query: 808  SIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTV 867
             I+ +LD KP IDSSS  G     + G+I +++V+F+YP+RPD+ I + + L + + +TV
Sbjct: 388  GIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTV 447

Query: 868  ALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNES 927
            ALVG SG GKST+ISLL R+YD   G++ +DGVD++   + +LR+ + +V QEP LFN +
Sbjct: 448  ALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCT 507

Query: 928  IRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
            I  NI+ GKE G T +E++AA   ANA  FI +LP+GY+T VG+RGTQLSGGQKQRIAIA
Sbjct: 508  IEENISLGKE-GITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIA 566

Query: 988  RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
            RA+++NPKILLLDEATSALDAESE IVQ+ALD+ +  RTT+I+AHRL+TIR AD I   K
Sbjct: 567  RALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCK 626

Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
            NG V E G H  LM    G+Y  LV
Sbjct: 627  NGQVVEVGDHRALMAQ-QGLYYDLV 650



 Score =  290 bits (742), Expect = 1e-77
 Identities = 186/571 (32%), Positives = 290/571 (50%), Gaps = 56/571 (9%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
            + IG  +A   GF  P  ++     +N F + N ++ L+Q    +L+F+ LA   GI SF
Sbjct: 754  LFIGMSTATIGGFIYPTYSVFFTSFMNVF-AGNPADFLSQGHFWALMFLVLAAAQGICSF 812

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGE 161
            L      +  E  +  +R+   + +L Q I FFD+  N +G++ +R++ D   ++ A+  
Sbjct: 813  LMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDF 872

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            +    +    +   G  +AF  GW++AL+++A +P +               ++    +A
Sbjct: 873  RFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFA 932

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
            ++G +A + + ++RTV +   E    E +  K+ I +   ++++   G+  G    +++ 
Sbjct: 933  DSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYL 992

Query: 282  SYGLAMWYGSKLVIAKG--YNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMF 339
                A   G  L+I          V+ V+ A+   + +LG  +     +A    A   +F
Sbjct: 993  LNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIF 1052

Query: 340  ETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALV 399
              +++  KID+   +G   + + G +  ++V F YP RP++EI  G S  V  G T ALV
Sbjct: 1053 GMLRKISKIDSLSLAG-EKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALV 1111

Query: 400  GQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------- 449
            G SG GKSTV++LLERFYD   GE+ IDG  +K L     R QI +VSQE          
Sbjct: 1112 GPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAE 1171

Query: 450  ----------------------------------------RQNGTQLSGGQKQRIAIARA 469
                                                       GTQLSGGQKQRIAIARA
Sbjct: 1172 NIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARA 1231

Query: 470  ILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQG 529
            +++NPKILLLDEATSALD ESE +VQEAL++    RT IV+AHRL T+++AD IAVV  G
Sbjct: 1232 LVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNG 1291

Query: 530  KIVERGTHSELTMDPHGAYSQLIRLQEGEKE 560
             I+E+GTH++L M   GAY +L + Q  EK+
Sbjct: 1292 TIIEKGTHTQL-MSEKGAYYKLTQKQMTEKK 1321



 Score =  286 bits (731), Expect = 3e-76
 Identities = 153/326 (46%), Positives = 214/326 (64%), Gaps = 4/326 (1%)

Query: 746  AHSSLYCTNAFIFYIGSILVHHRKATF--VEIFRVFFSLTMTAMSVSQSSTLFPDTNKAI 803
            A S LY  N   + +G  L+     T   + + RV +++T++  ++  +++ FP+  KA 
Sbjct: 986  ASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKAT 1045

Query: 804  DSAASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPS 863
             +   IF +L     IDS S  G  ++ + G +  ++V F+YP RP+I+I K L+ S+  
Sbjct: 1046 FAGGIIFGMLRKISKIDSLSLAG-EKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEP 1104

Query: 864  AKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPIL 923
             +T+ALVG SG GKSTV++LLERFYD   G + +DG +IKT      R Q+ +V QEP L
Sbjct: 1105 GQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTL 1164

Query: 924  FNESIRANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQ 982
            F+ SI  NI YG +  + T  ++  AA  AN HNFI+ LP+G++T VG+RGTQLSGGQKQ
Sbjct: 1165 FDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQ 1224

Query: 983  RIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADT 1042
            RIAIARA+++NPKILLLDEATSALD ESE++VQEALDR    RT +++AHRL T+  AD 
Sbjct: 1225 RIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADC 1284

Query: 1043 IAVIKNGMVAEKGRHDELMNNTHGVY 1068
            IAV+ NG + EKG H +LM+     Y
Sbjct: 1285 IAVVSNGTIIEKGTHTQLMSEKGAYY 1310



 Score = 33.5 bits (75), Expect = 3.2
 Identities = 38/168 (22%), Positives = 67/168 (39%), Gaps = 26/168 (15%)

Query: 611 GEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKP-ELPVILLGTIAAMVNGVVFPIFG 669
           G+ +D+N E  ++  + K ++  K SI +L +     E  ++ +GT+ A++ G   P+  
Sbjct: 37  GDNIDSNGEI-KITRDAKEEVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMS 95

Query: 670 FLFSAVISMF-------------YKPPEQQRKESRF--------WSLVYVGLGLVTLVVF 708
            L   V   F             + P  Q   ++ F        WS   + +G+      
Sbjct: 96  ILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQI 155

Query: 709 PLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHSSLYCTNAF 756
            +  Y +     ++  R+R      I+ QEI WF D  HS    T  F
Sbjct: 156 TVTCYLY--VAEQMNNRLRREFVKSILRQEISWF-DTNHSGTLATKLF 200


>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
           (P-glycoprotein 49)
          Length = 1302

 Score =  382 bits (982), Expect = e-105
 Identities = 256/806 (31%), Positives = 403/806 (49%), Gaps = 88/806 (10%)

Query: 28  FYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK-------------------VI 68
           ++ LF ++ R +  L+++  + A A     P   ++ G+                    +
Sbjct: 31  YFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFAL 90

Query: 69  NAFGSSNQ-SEVLNQVSKVSLLFVYLAIGSG-----ITSFLQVSCWMVTGER----QSAR 118
             FG   Q +    + +  +++    A G G     +  FL ++  +    R    Q  R
Sbjct: 91  PMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDR 150

Query: 119 IRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFV 178
           IR L+L+ +L+QDIA++DT + +    S+M+ D   ++E +GEK+   + L  TF  G V
Sbjct: 151 IRKLFLEAMLRQDIAWYDTSSGSN-FASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIV 209

Query: 179 IAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVA 238
            AF+ GW+L LV+L+CVP I+ A + +A +   +A +   +Y++A NV  +    +RTV 
Sbjct: 210 SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVF 269

Query: 239 SFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKG 298
           +F+G++K  E++   +  A     ++ + SG+G     LII+    LA+WYG  L++ + 
Sbjct: 270 AFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329

Query: 299 ------YNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYD 352
                 Y    ++ V+ A++ G+ +LG  SP + A A   AA   +F  I R  ++D  D
Sbjct: 330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389

Query: 353 TSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISL 412
             G   E+  G I    + FRYPARPDVEI  G ++ V  G T A VG SG GKST+I L
Sbjct: 390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQL 449

Query: 413 LERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE----------------------- 449
           ++RFYDP AG V +DG +L+ L + W+R QIG+V QE                       
Sbjct: 450 MQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509

Query: 450 -------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATS 484
                                     + G Q+SGGQKQRIAIARA+++ P++LLLDEATS
Sbjct: 510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATS 569

Query: 485 ALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDP 544
           ALD  SE  VQ ALE      TT+VVAHRL+TI +AD I  ++ G + E+GTH EL M+ 
Sbjct: 570 ALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEEL-MER 628

Query: 545 HGAYSQLIRLQEGEKEAEGSRSSEVDK-FGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
            G Y +L+ + + ++  E    +   +    + N+         +           +S S
Sbjct: 629 RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGS 688

Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
            R S            Q +    +K  +S K S  +L KLN PE   I++G IA++++G 
Sbjct: 689 SRDSGFRASTRRKRRSQRRKKKKDKEVVS-KVSFTQLMKLNSPEWRFIVVGGIASVMHGA 747

Query: 664 VFPIFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKL 722
            FP++G  F     +     +   R E    S+++VG+GL+  +   L+ Y F TAG K+
Sbjct: 748 TFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKM 807

Query: 723 IERIRSLTFAKIVHQEIRWFDDPAHS 748
             R+R   F  I+ Q+I +FDD  +S
Sbjct: 808 TTRLRKRAFGTIIGQDIAYFDDERNS 833



 Score =  287 bits (734), Expect = 1e-76
 Identities = 147/297 (49%), Positives = 201/297 (67%), Gaps = 2/297 (0%)

Query: 778  VFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSKPDIDSSSNDGVTQETVVGNIE 837
            V F++ M A ++  +S        A  +  ++FNI+D    +D     G   E   G+I 
Sbjct: 344  VLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIR 403

Query: 838  LQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLL 897
             + + F YP RPD++I K LT+ +   +TVA VG SG GKST+I L++RFYDP +G V L
Sbjct: 404  FEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKL 463

Query: 898  DGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGKEDGATEDEIIAAANAANAHNF 957
            DG D++T  + WLR Q+G+VGQEP+LF  +I  NI YG+   AT+ +I  AA AAN H+F
Sbjct: 464  DGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPS-ATQADIEKAARAANCHDF 522

Query: 958  ISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEA 1017
            I+ LP GYDT VGE+G Q+SGGQKQRIAIARA+++ P++LLLDEATSALD  SE+ VQ A
Sbjct: 523  ITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582

Query: 1018 LDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEKGRHDELMNNTHGVYASLVAL 1074
            L+  S   TT++VAHRL+TI  AD I  +K+G+VAE+G H+ELM    G+Y  LV++
Sbjct: 583  LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSI 638



 Score =  279 bits (713), Expect = 3e-74
 Identities = 186/570 (32%), Positives = 286/570 (49%), Gaps = 61/570 (10%)

Query: 43   MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
            +++G I+++ +G   PL  L  G         +   V  +V K+S++FV + + +G+ + 
Sbjct: 735  IVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNM 794

Query: 103  LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
            LQ   +   G + + R+R     TI+ QDIA+FD E N+ G + SR++ D   +Q A G 
Sbjct: 795  LQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGA 854

Query: 162  KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
            +VG  LQ  +T   G V+ F+  W+  L+ L  +P + ++       + K A + + +  
Sbjct: 855  RVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIE 914

Query: 222  EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
            EA  VA + + ++RTV     E++ +++Y  +I     A  ++    G+         F 
Sbjct: 915  EASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFL 974

Query: 282  SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
            +YG++M+YG  LV  +  N   ++ V  AL+ GS  LGQ             +A ++ + 
Sbjct: 975  AYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDL 1034

Query: 342  IKR-----KPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTT 396
             KR      P    Y+T    +E  +GDI   +V F YP R    I  G +L +   TT 
Sbjct: 1035 FKRTSTQPNPPQSPYNT----VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTV 1090

Query: 397  ALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------- 449
            ALVG SGSGKST + LL R+YDP +G V + GV      L  +R ++GLVSQE       
Sbjct: 1091 ALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRT 1150

Query: 450  ------------------------------------------RQNGTQLSGG-QKQRIAI 466
                                                      R   T    G QKQRIAI
Sbjct: 1151 IAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTSQLSGGQKQRIAI 1210

Query: 467  ARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVV 526
            ARA+++NPKIL+LDEATSALD ESE +VQ+AL++    RT + +AHRLTT+ +AD I V+
Sbjct: 1211 ARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVL 1270

Query: 527  QQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
            ++G +VE GTH EL M  +  Y+ L  +Q+
Sbjct: 1271 KRGVVVEHGTHDEL-MALNKIYANLYLMQQ 1299



 Score =  271 bits (693), Expect = 7e-72
 Identities = 155/325 (47%), Positives = 208/325 (63%), Gaps = 9/325 (2%)

Query: 759  YIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL---DS 815
            Y G ILV   +  + +I +V  +L   +  + Q+    P+ N AI SA  + ++     +
Sbjct: 981  YYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTST 1040

Query: 816  KPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGS 875
            +P+   S  +  T E   G+I  ++V F YPTR    I + L L+I  + TVALVG SGS
Sbjct: 1041 QPNPPQSPYN--TVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGS 1098

Query: 876  GKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYG 935
            GKST + LL R+YDP SG V L GV    F +  LR ++GLV QEP+LF+ +I  NIAYG
Sbjct: 1099 GKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158

Query: 936  KE--DGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
                D  +  EII AA  +N HNFIS+LP GYDT +G+  +QLSGGQKQRIAIARA+++N
Sbjct: 1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKT-SQLSGGQKQRIAIARALVRN 1217

Query: 994  PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
            PKIL+LDEATSALD ESE++VQ+ALD     RT + +AHRLTT+R AD I V+K G+V E
Sbjct: 1218 PKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVE 1277

Query: 1054 KGRHDELMNNTHGVYASLVALHSTA 1078
             G HDELM   + +YA+L  +   +
Sbjct: 1278 HGTHDELM-ALNKIYANLYLMQQVS 1301


>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
           (P-glycoprotein 65)
          Length = 1302

 Score =  369 bits (948), Expect = e-101
 Identities = 244/759 (32%), Positives = 384/759 (50%), Gaps = 68/759 (8%)

Query: 50  AMANGFASPLMTLLL---GKVI-NAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQV 105
           AM  G +S +  L L   GK + NA    N   + +      +L    ++   I+    V
Sbjct: 80  AMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSV 139

Query: 106 SCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGK 165
             + +   RQ  R+R     ++++QDI + D  +      S M  D   I++ + EKVG 
Sbjct: 140 DVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQS-MVDDVEKIRDGISEKVGH 198

Query: 166 FLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGN 225
           F+ L   F     I+F  GW+L L + + +P +++   ++A    K+  R Q +YA AGN
Sbjct: 199 FVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGN 258

Query: 226 VANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGL 285
           +A + + S+RTV SF GEK  +++Y + +  A  A   +   SG+    L  +++ S   
Sbjct: 259 LAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAG 318

Query: 286 AMWYGSKLVIA------KGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMF 339
           A WYG  L+I       K Y    +M     ++ G+ ++ +T+P L +FA  +  A  +F
Sbjct: 319 AFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378

Query: 340 ETIKRKPKIDAYDTSGLVLE-DIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTAL 398
           + I    KID   T G +L   ++GD+E +DV FRYP+RP+V +  G ++ + +G T AL
Sbjct: 379 KVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVAL 438

Query: 399 VGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------- 449
           VG SG GKST + LL+RFYDP  G VL+D ++++   ++W+R  I +V QE         
Sbjct: 439 VGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIA 498

Query: 450 ---------------------------------------RQNGTQLSGGQKQRIAIARAI 470
                                                   + G+QLSGGQKQRIAIARA+
Sbjct: 499 QNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARAL 558

Query: 471 LKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGK 530
           ++NPKILLLDEATSALD +SE  VQ+AL+     RTTIVV+HRL+ I  AD I  +  GK
Sbjct: 559 IQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGK 618

Query: 531 IVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRI 590
           ++E G+H +L M   GAY  ++R  +     E  +   ++      ++ +      T  +
Sbjct: 619 VLEEGSHDDL-MALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQK-SLALFEKSFETSPL 676

Query: 591 SFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPV 650
           +F +   Q +S+      +   I D N +  +    EKP      S  R+ +L K E   
Sbjct: 677 NFEK--GQKNSVQFEEPIIKALIKDTNAQSAEAP-PEKPNFFRTFS--RILQLAKQEWCY 731

Query: 651 ILLGTIAAMVNGVVFPIFGFLFSA-VISMFYKPPEQQRKESRFWSLVYVGLGLVTLVVFP 709
           ++LGTI+A+  G ++P F  +F     ++  K PE   + +   S   +GL  +T +V  
Sbjct: 732 LILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCF 791

Query: 710 LKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
           L+ Y F  AG  L  R+R++TF  +V+QE+ WFDD  +S
Sbjct: 792 LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNS 830



 Score =  308 bits (789), Expect = 5e-83
 Identities = 201/607 (33%), Positives = 317/607 (52%), Gaps = 60/607 (9%)

Query: 7    VHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
            + + ++ S +    K N    F ++   A + +   +I+GTISA+A GF  P   ++ G+
Sbjct: 697  IKDTNAQSAEAPPEKPNFFRTFSRILQLAKQ-EWCYLILGTISAVAVGFLYPAFAVIFGE 755

Query: 67   VINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKT 126
               A    +  + L + + +S   + LA  +G+  FLQ   +   G   + R+R++    
Sbjct: 756  FYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNA 815

Query: 127  ILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGW 185
            ++ Q++ +FD E N+ G + +R+SG+ + IQ A+G  +   +Q  S F     +A    W
Sbjct: 816  MVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNW 875

Query: 186  RLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKK 245
            +LAL+ LA  P IV +    A +M+   +R +    EA  +A +++ ++RTVA    E  
Sbjct: 876  KLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREAD 935

Query: 246  AIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVM 305
             I +Y  +I+     + Q+    G+   T+    F +Y +A+ YG  LV         ++
Sbjct: 936  VIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDII 995

Query: 306  TVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDA-----YDTSGLVLED 360
             V   L+ GSM L Q+     AF+A   A +++F+ + RKPKI +      +T    L  
Sbjct: 996  KVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNL 1055

Query: 361  IKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPN 420
             +G +  R + FRYP RPD +I  G  L V  G T ALVG SG GKST + LL+R+YDP+
Sbjct: 1056 FEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPD 1114

Query: 421  AGEVLIDGVNLK-NLQLRWIREQIGLVSQE------------------------------ 449
             G + ID  +++ +L L  +R ++G+VSQE                              
Sbjct: 1115 EGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAA 1174

Query: 450  --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
                                   GTQLSGGQKQRIAIARA+++NPKILLLDEATSALD +
Sbjct: 1175 KSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQ 1234

Query: 490  SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
            SE +VQ+AL+     RT IV+AHRL+T+ +AD I V+Q G++VE+G H +L +   G Y+
Sbjct: 1235 SEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQL-ISQGGIYA 1293

Query: 550  QLIRLQE 556
            +L + Q+
Sbjct: 1294 KLHKTQK 1300



 Score =  287 bits (734), Expect = 1e-76
 Identities = 156/328 (47%), Positives = 219/328 (66%), Gaps = 7/328 (2%)

Query: 750  LYCTNAFIFYIGSIL----VHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
            L C  AF + +  I+    V +++ T   +   FF + + A ++++++        A   
Sbjct: 314  LSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGC 373

Query: 806  AASIFNILDSKPDIDSSSNDG-VTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSA 864
            A ++F ++D    ID  S DG +    + G++E Q V F YP+RP++ + + L + I + 
Sbjct: 374  ATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAG 433

Query: 865  KTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILF 924
            +TVALVG SG GKST + LL+RFYDP  G VLLD +DI+ + I WLR  + +VGQEP+LF
Sbjct: 434  QTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLF 493

Query: 925  NESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRI 984
              +I  NI+YGK  GAT+ EI AAA  A AH FI++LP+ Y + +GERG+QLSGGQKQRI
Sbjct: 494  LGTIAQNISYGKP-GATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRI 552

Query: 985  AIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIA 1044
            AIARA+++NPKILLLDEATSALD +SE+ VQ+ALD  S  RTT++V+HRL+ IRGAD I 
Sbjct: 553  AIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIV 612

Query: 1045 VIKNGMVAEKGRHDELMNNTHGVYASLV 1072
             I +G V E+G HD+LM    G Y ++V
Sbjct: 613  FIHDGKVLEEGSHDDLM-ALEGAYYNMV 639



 Score =  283 bits (723), Expect = 2e-75
 Identities = 157/347 (45%), Positives = 219/347 (62%), Gaps = 10/347 (2%)

Query: 734  IVHQEIRW---FDDPAHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVS 790
            ++ Q++RW    +    +S +   A     G +LV   +  F +I +V  +L   +M ++
Sbjct: 950  LIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLA 1009

Query: 791  QSSTLFPDTNKAIDSAASIFNILDSKPDIDSS----SNDGVTQETVVGNIELQHVNFSYP 846
            QS    P  + A+ +   +F ILD KP I S      N    Q  +   +  + + F YP
Sbjct: 1010 QSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYP 1069

Query: 847  TRPDIQIFKDLTLSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIK-TF 905
            TRPD +I   L L +   +TVALVG SG GKST + LL+R+YDP+ G + +D  DI+   
Sbjct: 1070 TRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDL 1129

Query: 906  RISWLRQQMGLVGQEPILFNESIRANIAYG-KEDGATEDEIIAAANAANAHNFISSLPDG 964
             +  +R ++G+V QEP LF  SI  NIAYG      +  EIIAAA +ANAH+FI SLP+G
Sbjct: 1130 TLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNG 1189

Query: 965  YDTSVGERGTQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLN 1024
            YDT +G RGTQLSGGQKQRIAIARA+++NPKILLLDEATSALD +SE++VQ+ALD     
Sbjct: 1190 YDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG 1249

Query: 1025 RTTVIVAHRLTTIRGADTIAVIKNGMVAEKGRHDELMNNTHGVYASL 1071
            RT +++AHRL+T++ AD I VI+NG V E+G H +L++   G+YA L
Sbjct: 1250 RTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ-GGIYAKL 1295


>AB10_MOUSE (Q9JI39) ATP-binding cassette, sub-family B, member 10,
           mitochondrial precursor (ATP-binding cassette
           transporter 10) (ABC transporter 10 protein)
           (ABC-mitochondrial erythroid protein) (ABC-me protein)
          Length = 715

 Score =  303 bits (776), Expect = 2e-81
 Identities = 196/556 (35%), Positives = 304/556 (54%), Gaps = 78/556 (14%)

Query: 64  LGKVINAF---GSSNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARI 119
           LG++I+      S    + L ++  V + +F+  A  +GI  +L  S    +G+    R+
Sbjct: 157 LGRIIDVIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQS----SGQSIVNRL 212

Query: 120 RSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVI 179
           R+    +IL+Q++AFFD +T TGE+I+R+S DT L+  ++ E +   L+ G+    G  +
Sbjct: 213 RTSLFSSILRQEVAFFD-KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGM 271

Query: 180 AFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVAS 239
            F     LA  +L+ VP I V        + K++   Q + AEA  +A + +G++RT+ +
Sbjct: 272 MFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRA 331

Query: 240 FTGEKKAIEKYNSKIKIAYTAMVQQSIA-------SGIGMGTLLLIIFCSYGLAMWYGSK 292
           F  E   +EKY  ++        ++++A       +G+    ++L +    GL M     
Sbjct: 332 FGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHM 391

Query: 293 LVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYD 352
            V       G + + ++      +S+G  S        G  A  +++E ++R+P++   +
Sbjct: 392 TV-------GELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNE 444

Query: 353 TSGLVLED--IKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVI 410
             G+VL++   +G +E R+VHF YPARP+V +F  FSL +PSG+ TALVG SGSGKSTV+
Sbjct: 445 --GMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVV 502

Query: 411 SLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------------------- 449
           SLL R YDPN+G V +DG +++ L   W+R +IG VSQE                     
Sbjct: 503 SLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSS 562

Query: 450 ------------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLL 479
                                          + G  LSGGQKQRIAIARA+LKNPKILLL
Sbjct: 563 VTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLL 622

Query: 480 DEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSE 539
           DEATSALDAE+EH+VQEAL++++  RT +++AHRL+TI +A+ +AV+  GKI E GTH E
Sbjct: 623 DEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEE 682

Query: 540 LTMDPHGAYSQLIRLQ 555
           L + P+G Y +L+  Q
Sbjct: 683 LLLKPNGLYRKLMNKQ 698



 Score =  291 bits (746), Expect = 5e-78
 Identities = 151/325 (46%), Positives = 213/325 (65%), Gaps = 2/325 (0%)

Query: 757  IFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSK 816
            + Y G +L+     T  E+           +S+   S+ + +  K + +   ++ +L+ +
Sbjct: 378  VLYKGGLLMGSAHMTVGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQ 437

Query: 817  PDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSG 876
            P +  +    + ++T  G +E ++V+F+YP RP++ +F+D +LSIPS    ALVG SGSG
Sbjct: 438  PRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSG 497

Query: 877  KSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGK 936
            KSTV+SLL R YDPNSG V LDG DI+     WLR ++G V QEP+LF+ S+  NIAYG 
Sbjct: 498  KSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGA 557

Query: 937  ED--GATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNP 994
            ++    T  ++  AA  ANA  FI S P G+DT VGE+G  LSGGQKQRIAIARA+LKNP
Sbjct: 558  DNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNP 617

Query: 995  KILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEK 1054
            KILLLDEATSALDAE+E +VQEALDR+   RT +I+AHRL+TI+ A+ +AV+ +G + E 
Sbjct: 618  KILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEH 677

Query: 1055 GRHDELMNNTHGVYASLVALHSTAS 1079
            G H+EL+   +G+Y  L+   S  S
Sbjct: 678  GTHEELLLKPNGLYRKLMNKQSFLS 702



 Score = 41.6 bits (96), Expect = 0.012
 Identities = 26/121 (21%), Positives = 54/121 (44%), Gaps = 1/121 (0%)

Query: 624 DNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKPP 683
           D+  +P  + ++ +W+L  L +PE   +        V+ V+     F    +I + Y  P
Sbjct: 109 DSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNP 168

Query: 684 EQQRKESRF-WSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWF 742
            +   +S      V   + L       ++ Y   ++G  ++ R+R+  F+ I+ QE+ +F
Sbjct: 169 SEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFF 228

Query: 743 D 743
           D
Sbjct: 229 D 229


>AB10_HUMAN (Q9NRK6) ATP-binding cassette, sub-family B, member 10,
           mitochondrial precursor (ATP-binding cassette
           transporter 10) (ABC transporter 10 protein)
           (Mitochondrial ATP-binding cassette 2) (M-ABC2)
          Length = 738

 Score =  298 bits (763), Expect = 5e-80
 Identities = 188/550 (34%), Positives = 297/550 (53%), Gaps = 66/550 (12%)

Query: 64  LGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLY 123
           LGK+I+   ++   +  + ++++ L    + +     + ++V     +G+R   R+R+  
Sbjct: 192 LGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSL 251

Query: 124 LKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIK 183
             +IL+Q++AFFD +T TGE+I+R+S DT L+  ++ E +   L+ G+    G  + F  
Sbjct: 252 FSSILRQEVAFFD-KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFV 310

Query: 184 GWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGE 243
              LA  +L+ VP + +        + K+    Q + A+A  +A + +G++RTV +F  E
Sbjct: 311 SPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKE 370

Query: 244 KKAIEKYNSKIKIAYTAMVQQSIA-------SGIGMGTLLLIIFCSYGLAMWYGSKLVIA 296
              IEKY SK+        ++++A       +G+    ++L +    GL M      V  
Sbjct: 371 MTEIEKYASKVDHVMQLARKEAVARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTV-- 428

Query: 297 KGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGL 356
                G + + ++      +S+G  S        G  A  +++E ++R+PK+   +   L
Sbjct: 429 -----GELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVIL 483

Query: 357 VLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERF 416
             +  +G +E ++VHF YPARP+V IF  FSL +PSG+ TALVG SGSGKSTV+SLL R 
Sbjct: 484 NEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRL 543

Query: 417 YDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------------------------- 449
           Y+P +G + +DG +++ L   W+R +IG VSQE                           
Sbjct: 544 YNPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEI 603

Query: 450 ------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSA 485
                                    + G  LSGGQKQRIAIARA+LKNPKILLLDEATSA
Sbjct: 604 QRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSA 663

Query: 486 LDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPH 545
           LDAE+E++VQEAL++++  RT +V+AHRL+TI +A+ +AV+ QGKI E G H EL   P+
Sbjct: 664 LDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPN 723

Query: 546 GAYSQLIRLQ 555
           G Y +L+  Q
Sbjct: 724 GIYRKLMNKQ 733



 Score =  285 bits (730), Expect = 4e-76
 Identities = 149/325 (45%), Positives = 213/325 (64%), Gaps = 2/325 (0%)

Query: 757  IFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSK 816
            + Y G +L+     T  E+           +S+   S+ + +  K + +   ++ +L+ +
Sbjct: 413  VLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472

Query: 817  PDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSG 876
            P +  +    + +++  G +E ++V+F+YP RP++ IF+D +LSIPS    ALVG SGSG
Sbjct: 473  PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532

Query: 877  KSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGK 936
            KSTV+SLL R Y+P SG + LDG DI+     WLR ++G V QEPILF+ SI  NIAYG 
Sbjct: 533  KSTVLSLLLRLYNPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGA 592

Query: 937  ED--GATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNP 994
            +D    T +EI   A  ANA  FI + P G++T VGE+G  LSGGQKQRIAIARA+LKNP
Sbjct: 593  DDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNP 652

Query: 995  KILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEK 1054
            KILLLDEATSALDAE+E +VQEALDR+   RT +++AHRL+TI+ A+ +AV+  G + E 
Sbjct: 653  KILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEY 712

Query: 1055 GRHDELMNNTHGVYASLVALHSTAS 1079
            G+H+EL++  +G+Y  L+   S  S
Sbjct: 713  GKHEELLSKPNGIYRKLMNKQSFIS 737



 Score = 32.7 bits (73), Expect = 5.4
 Identities = 19/77 (24%), Positives = 38/77 (48%), Gaps = 5/77 (6%)

Query: 670 FLFSAVISMFYKPPEQQRKESRFWSLVYVGLGLVTL---VVFPLKNYFFGTAGGKLIERI 726
           F    +I + Y  P     ++   + + +GL  V L       ++ Y   T+G +++ R+
Sbjct: 190 FFLGKIIDVIYTNPTVDYSDNL--TRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRL 247

Query: 727 RSLTFAKIVHQEIRWFD 743
           R+  F+ I+ QE+ +FD
Sbjct: 248 RTSLFSSILRQEVAFFD 264


>ABC8_HUMAN (Q9NUT2) ATP-binding cassette, sub-family B, member 8,
            mitochondrial precursor (Mitochondrial ATP-binding
            cassette 1) (M-ABC1)
          Length = 735

 Score =  298 bits (762), Expect = 7e-80
 Identities = 159/335 (47%), Positives = 220/335 (65%), Gaps = 3/335 (0%)

Query: 739  IRWFDDPAHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPD 798
            I  F   ++ +  C      +IG  LV  ++ T  ++     +      S++  S LF  
Sbjct: 375  IALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQ 434

Query: 799  TNKAIDSAASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLT 858
              + + + A +F  +   P I  S    V +E + G++  Q+V FSYP RP  ++ KD T
Sbjct: 435  VVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFT 494

Query: 859  LSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQM-GLV 917
            L++P  K VALVG+SG GK+TV SLLERFYDP +G V+LDG D++T   SWLR Q+ G +
Sbjct: 495  LTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFI 554

Query: 918  GQEPILFNESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLS 977
             QEP+LF  +I  NI +GK + A+++E+  AA  ANAH FI+S P+GY+T VGERGT LS
Sbjct: 555  SQEPVLFGTTIMENIRFGKLE-ASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLS 613

Query: 978  GGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTI 1037
            GGQKQR+AIARA++K P +L+LDEATSALDAESER+VQEALDR S  RT +++AHRL+T+
Sbjct: 614  GGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTV 673

Query: 1038 RGADTIAVIKNGMVAEKGRHDELMNNTHGVYASLV 1072
            RGA  I V+ +G V E G H+EL+    G+YA L+
Sbjct: 674  RGAHCIVVMADGRVWEAGTHEELLKK-GGLYAELI 707



 Score =  271 bits (693), Expect = 7e-72
 Identities = 184/590 (31%), Positives = 294/590 (49%), Gaps = 65/590 (11%)

Query: 42  LMIIGTISAMANGFA--SPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGI 99
           L+++G    +A G A  +  + LLLG+++       +  V + +++   L  +L I  G+
Sbjct: 145 LLVLGVAVVLALGAALVNVQIPLLLGQLVKVVAKYTRDHVGSFMTESQNLSTHLLILYGV 204

Query: 100 TSFLQVSCWMV---TGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQ 156
              L     ++    GER +  +R     ++L+Q+I FFD    TG+++SR++ D    +
Sbjct: 205 QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQNITFFDAN-KTGQLVSRLTTDVQEFK 263

Query: 157 EAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRG 216
            +    + + L+  S   G  V   +   RL L+L+   P ++  G  M   + K++ + 
Sbjct: 264 SSFKLVISQGLRSCSQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQC 323

Query: 217 QVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLL 276
           Q   A A  VA++ +G++RTV +   E++  E+Y ++++       +      +  G   
Sbjct: 324 QEHIARAMGVADEALGNVRTVRALAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN 383

Query: 277 LIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAY 336
           +   C     ++ G  LV  +   GG +M+ ++A  T   S+   S        G +A  
Sbjct: 384 IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGA 443

Query: 337 KMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTT 396
           ++FE +   P I       +  E ++G +  ++V F YP RP  E+   F+L +P G   
Sbjct: 444 RVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIV 503

Query: 397 ALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQ-IGLVSQE------ 449
           ALVGQSG GK+TV SLLERFYDP AG V++DG +L+ L   W+R Q +G +SQE      
Sbjct: 504 ALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT 563

Query: 450 ------------------------------------------RQNGTQLSGGQKQRIAIA 467
                                                      + GT LSGGQKQR+AIA
Sbjct: 564 TIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIA 623

Query: 468 RAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQ 527
           RA++K P +L+LDEATSALDAESE +VQEAL++    RT +V+AHRL+T+  A  I V+ 
Sbjct: 624 RALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMA 683

Query: 528 QGKIVERGTHSELTMDPHGAYSQLIRLQEGE---------KEAEGSRSSE 568
            G++ E GTH EL +   G Y++LIR Q  +         K+ EG RS +
Sbjct: 684 DGRVWEAGTHEEL-LKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQ 732


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.319    0.134    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114,804,414
Number of Sequences: 164201
Number of extensions: 4723904
Number of successful extensions: 22270
Number of sequences better than 10.0: 1020
Number of HSP's better than 10.0 without gapping: 884
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 16913
Number of HSP's gapped (non-prelim): 4048
length of query: 1079
length of database: 59,974,054
effective HSP length: 121
effective length of query: 958
effective length of database: 40,105,733
effective search space: 38421292214
effective search space used: 38421292214
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)


Medicago: description of AC140022.3