
BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC140022.3 - phase: 0
(1079 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 522 e-147
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 521 e-147
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 519 e-146
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 495 e-139
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 492 e-138
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 491 e-138
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 491 e-138
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 490 e-138
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 490 e-138
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 483 e-135
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 459 e-128
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 447 e-125
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 444 e-124
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 432 e-120
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 407 e-113
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 382 e-105
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 369 e-101
AB10_MOUSE (Q9JI39) ATP-binding cassette, sub-family B, member 1... 303 2e-81
AB10_HUMAN (Q9NRK6) ATP-binding cassette, sub-family B, member 1... 298 5e-80
ABC8_HUMAN (Q9NUT2) ATP-binding cassette, sub-family B, member 8... 298 7e-80
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 522 bits (1345), Expect = e-147
Identities = 299/794 (37%), Positives = 460/794 (57%), Gaps = 86/794 (10%)
Query: 25 IVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSS---------- 74
+V + +F +A LD M++GT++A+ +G A PLM L+ G + ++F S
Sbjct: 32 VVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNN 91
Query: 75 ----NQSEVLNQVSK--VSLLFVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLKT 126
N S++ ++ + + + Y IG+G I +++QVS W + RQ +IR +
Sbjct: 92 ATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHA 151
Query: 127 ILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWR 186
I+ Q+I +FD + GE+ +R++ D I E +G+K+G F Q +TFFGGF+I F +GW+
Sbjct: 152 IMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210
Query: 187 LALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKA 246
L LV+LA P + ++ A +++ + AYA+AG VA + + ++RTV +F G+KK
Sbjct: 211 LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270
Query: 247 IEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMT 306
+E+YN+ ++ A ++++I + I MG L+I+ SY LA WYG+ LVI+K Y+ G V+T
Sbjct: 271 LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330
Query: 307 VVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIE 366
V A++ G+ S+GQ SP++ AFA + AAY++F I KP ID++ +G ++IKG++E
Sbjct: 331 VFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390
Query: 367 LRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLI 426
+++HF YP+R DV+I G +L V SG T ALVG SG GKST + LL+R YDP G V I
Sbjct: 391 FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450
Query: 427 DGVNLKNLQLRWIREQIGLVSQE---------------RQN------------------- 452
DG +++ + +R++RE IG+VSQE R+N
Sbjct: 451 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510
Query: 453 --------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEAL 498
G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ AL
Sbjct: 511 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570
Query: 499 EKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGE 558
+K RTTIV+AHRL+T+ +AD IA G IVE+G H EL M G Y +L+ Q
Sbjct: 571 DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEEL-MREKGIYFKLVMTQTAG 629
Query: 559 KEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDAN 617
E E G+ E DNL++ S S +R S S+ H Q D
Sbjct: 630 NEIELGNEVGESKNEIDNLDM-----SSKDSASSLIRRRSTRRSIRGPHDQ------DRK 678
Query: 618 IEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVIS 677
+ + + + P + S WR+ KLN E P ++G A+VNG + P F +FS V+
Sbjct: 679 LSTKEALDEDVPPI----SFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVG 734
Query: 678 MFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIV 735
+F + E +R +S +SL+++ LG+++ + F L+ + FG AG L +R+R + F ++
Sbjct: 735 VFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSML 794
Query: 736 HQEIRWFDDPAHSS 749
Q++ WFD+P +++
Sbjct: 795 RQDVSWFDNPKNTT 808
Score = 348 bits (892), Expect = 6e-95
Identities = 208/598 (34%), Positives = 321/598 (52%), Gaps = 54/598 (9%)
Query: 14 STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
ST++ +++ + F+++ + + ++G A+ NG P +++ KV+ F
Sbjct: 680 STKEALDEDVPPISFWRILKL-NSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTR 738
Query: 74 SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
+ E S + SLLF+ L + S IT FLQ + GE + R+R + K++L+QD+
Sbjct: 739 NTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDV 798
Query: 133 AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
++FD NT G + +R++ D ++ A G ++ Q + G +I+ I GW+L L+L
Sbjct: 799 SWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLL 858
Query: 192 LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
LA VP I +AG +++ A++ + +G +A + + + RTV S T E+K Y
Sbjct: 859 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYA 918
Query: 252 SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
++I Y ++++ GI +++ SY +G+ LV + V+ V A+
Sbjct: 919 QSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAI 978
Query: 312 VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
V G+M++GQ S +A K +A + I++ P ID+Y T GL ++G+++ +V
Sbjct: 979 VFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVV 1038
Query: 372 FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
F YP RPD+ + G +L V G T ALVG SG GKSTV+ LLERFYDP AG V +DG +
Sbjct: 1039 FNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEV 1098
Query: 432 KNLQLRWIREQIGLVSQE------------------------------------------ 449
L ++W+R +G+VSQE
Sbjct: 1099 NQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESL 1158
Query: 450 --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K
Sbjct: 1159 PDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1218
Query: 502 ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
RT IV+AHRL+TI +AD I V+Q GK+ E GTH +L + G Y ++ +Q G K
Sbjct: 1219 REGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQL-LAQKGIYFSMVSVQAGAK 1275
Score = 319 bits (817), Expect = 3e-86
Identities = 168/330 (50%), Positives = 221/330 (66%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV TF + VF ++ AM+V Q S+ PD KA SA+ I
Sbjct: 946 MYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHI 1005
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P IDS S G+ T+ GN++ V F+YPTRPDI + + L L + +T+AL
Sbjct: 1006 IMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLAL 1065
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G V LDG ++ + WLR +G+V QEPILF+ SI
Sbjct: 1066 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIA 1125
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG ++DEI AA AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1126 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1185
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1186 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1245
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
G V E G H +L+ G+Y S+V++ + A
Sbjct: 1246 GKVKEHGTHQQLLAQ-KGIYFSMVSVQAGA 1274
Score = 317 bits (813), Expect = 8e-86
Identities = 163/323 (50%), Positives = 223/323 (68%), Gaps = 2/323 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ G+ LV ++ + ++ VFF++ + A S+ Q+S A +A I
Sbjct: 303 IYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEI 362
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
FNI+D+KP IDS S +G + + GN+E ++++FSYP+R D+QI K L L + S +TVAL
Sbjct: 363 FNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVAL 422
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + LL+R YDP G V +DG DI+T + +LR+ +G+V QEP+LF +I
Sbjct: 423 VGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIA 482
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+E+ T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIAIARA
Sbjct: 483 ENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 541
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA G
Sbjct: 542 LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGG 601
Query: 1050 MVAEKGRHDELMNNTHGVYASLV 1072
++ E+G H+ELM G+Y LV
Sbjct: 602 VIVEQGNHEELMRE-KGIYFKLV 623
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein
3) (MDR1A)
Length = 1276
Score = 521 bits (1342), Expect = e-147
Identities = 297/787 (37%), Positives = 459/787 (57%), Gaps = 85/787 (10%)
Query: 31 LFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS----SNQSEVLNQVSKV 86
+F +A LD M++GT++A+ +G A PLM L+ G + ++F S S S +++ K
Sbjct: 38 MFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKR 97
Query: 87 SLL-----------FVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIA 133
++ + Y IG+G I +++QVS W + RQ +IR + I+ Q+I
Sbjct: 98 AMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIG 157
Query: 134 FFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLA 193
+FD + GE+ +R++ D I E +G+K+G F Q +TFFGGF+I F +GW+L LV+LA
Sbjct: 158 WFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILA 216
Query: 194 CVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSK 253
P + ++ A +++ + AYA+AG VA + + ++RTV +F G+KK +E+YN+
Sbjct: 217 ISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNN 276
Query: 254 IKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVT 313
++ A ++++I + I MG L+I+ SY LA WYG+ LVI+K Y+ G V+TV +++
Sbjct: 277 LEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLI 336
Query: 314 GSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFR 373
G+ S+GQ SP++ AFA + AAY++F+ I KP ID++ SG ++I+G++E +++HF
Sbjct: 337 GAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFS 396
Query: 374 YPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKN 433
YP+R +V+I G +L V SG T ALVG SG GKST + L++R YDP G V IDG +++
Sbjct: 397 YPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRT 456
Query: 434 LQLRWIREQIGLVSQE-------------------------------------------- 449
+ +R++RE IG+VSQE
Sbjct: 457 INVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQF 516
Query: 450 ----RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKR 505
+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ AL+K R
Sbjct: 517 DTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGR 576
Query: 506 TTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAE-GS 564
TTIV+AHRL+T+ +AD IA G IVE+G H EL M G Y +L+ Q E E G+
Sbjct: 577 TTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMTQTAGNEIELGN 635
Query: 565 RSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVD 624
+ + DNL++ +GS S +R S S+ H Q D + +
Sbjct: 636 EACKSKDEIDNLDMSSKDSGS-----SLIRRRSTRKSICGPHDQ------DRKLSTKEAL 684
Query: 625 NNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYK--P 682
+ + P S WR+ KLN E P ++G A++NG + P F +FS V+ +F P
Sbjct: 685 DEDVPPA----SFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGP 740
Query: 683 PEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWF 742
PE QR+ S +SL+++ LG+++ + F L+ + FG AG L +R+R + F ++ Q++ WF
Sbjct: 741 PETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWF 800
Query: 743 DDPAHSS 749
DDP +++
Sbjct: 801 DDPKNTT 807
Score = 347 bits (891), Expect = 8e-95
Identities = 207/570 (36%), Positives = 308/570 (53%), Gaps = 53/570 (9%)
Query: 44 IIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKV-SLLFVYLAIGSGITSF 102
++G A+ NG P +++ KV+ F + E Q S + SLLF+ L I S IT F
Sbjct: 708 VVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFF 767
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
LQ + GE + R+R + K++L+QD+++FD NT G + +R++ D ++ A G
Sbjct: 768 LQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGS 827
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
++ Q + G +I+ I GW+L L+LLA VP I +AG +++ A++ +
Sbjct: 828 RLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELE 887
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
+G +A + + + RTV S T E+K Y ++I Y ++++ GI +++
Sbjct: 888 GSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYF 947
Query: 282 SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
SY +G+ LV + V+ V A+V G+M++GQ S +A +A +
Sbjct: 948 SYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRI 1007
Query: 342 IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
I++ P+ID+Y T GL ++G+++ F YP RP + + G SL V G T ALVG
Sbjct: 1008 IEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGS 1067
Query: 402 SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
SG GKSTV+ LLERFYDP AG V +DG +K L ++W+R Q+G+VSQE
Sbjct: 1068 SGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENI 1127
Query: 450 --------------------------------------RQNGTQLSGGQKQRIAIARAIL 471
GTQLSGGQKQRIAIARA++
Sbjct: 1128 AYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALV 1187
Query: 472 KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
+ P ILLLDEATSALD ESE +VQEAL+K RT IV+AHRL+TI +AD I V+Q GK+
Sbjct: 1188 RQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKV 1247
Query: 532 VERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
E GTH +L + G Y ++ +Q G K +
Sbjct: 1248 KEHGTHQQL-LAQKGIYFSMVSVQAGAKRS 1276
Score = 320 bits (819), Expect = 2e-86
Identities = 167/330 (50%), Positives = 222/330 (66%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV + TF + VF ++ AM+V Q S+ PD KA SA+ I
Sbjct: 945 MYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHI 1004
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P+IDS S G+ + GN++ F+YPTRP I + + L+L + +T+AL
Sbjct: 1005 IRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLAL 1064
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G V LDG +IK + WLR Q+G+V QEPILF+ SI
Sbjct: 1065 VGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIA 1124
Query: 930 ANIAYGKEDGATE-DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG +EI+ AA AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1125 ENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1184
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1185 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1244
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
G V E G H +L+ G+Y S+V++ + A
Sbjct: 1245 GKVKEHGTHQQLLAQ-KGIYFSMVSVQAGA 1273
Score = 316 bits (810), Expect = 2e-85
Identities = 163/323 (50%), Positives = 221/323 (67%), Gaps = 2/323 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ G+ LV ++ + ++ VFFS+ + A SV Q+S A +A +
Sbjct: 302 IYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEV 361
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F I+D+KP IDS S G + + GN+E ++++FSYP+R ++QI K L L + S +TVAL
Sbjct: 362 FKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVAL 421
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + L++R YDP G V +DG DI+T + +LR+ +G+V QEP+LF +I
Sbjct: 422 VGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIA 481
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+ED T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIAIARA
Sbjct: 482 ENIRYGRED-VTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA 540
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA G
Sbjct: 541 LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGG 600
Query: 1050 MVAEKGRHDELMNNTHGVYASLV 1072
++ E+G HDELM G+Y LV
Sbjct: 601 VIVEQGNHDELMRE-KGIYFKLV 622
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein
1) (CD243 antigen)
Length = 1280
Score = 519 bits (1336), Expect = e-146
Identities = 291/808 (36%), Positives = 468/808 (57%), Gaps = 86/808 (10%)
Query: 12 SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
++ +++ + V + +F +++ LD M++GT++A+ +G PLM L+ G++ + F
Sbjct: 20 NNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIF 79
Query: 72 GSS-NQSEVLNQVSKVSLL-----------------FVYLAIGSGI--TSFLQVSCWMVT 111
++ N ++++ ++ S + + Y IG+G+ +++QVS W +
Sbjct: 80 ANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA 139
Query: 112 GERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGS 171
RQ +IR + I++Q+I +FD + GE+ +R++ D I E +G+K+G F Q +
Sbjct: 140 AGRQIHKIRKQFFHAIMRQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQSMA 198
Query: 172 TFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTV 231
TFF GF++ F +GW+L LV+LA P + ++ A A +++ + +AYA+AG VA + +
Sbjct: 199 TFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVL 258
Query: 232 GSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGS 291
++RTV +F G+KK +E+YN ++ A ++++I + I +G L+I+ SY LA WYG+
Sbjct: 259 AAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGT 318
Query: 292 KLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAY 351
LV++ Y+ G V+TV +++ G+ S+GQ SPS+ AFA + AAY++F+ I KP ID+Y
Sbjct: 319 TLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSY 378
Query: 352 DTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVIS 411
SG ++IKG++E R+VHF YP+R +V+I G +L V SG T ALVG SG GKST +
Sbjct: 379 SKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQ 438
Query: 412 LLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------RQN---- 452
L++R YDP G V +DG +++ + +R++RE IG+VSQE R+N
Sbjct: 439 LMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 498
Query: 453 -----------------------------GTQLSGGQKQRIAIARAILKNPKILLLDEAT 483
G QLSGGQKQRIAIARA+++NPKILLLDEAT
Sbjct: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558
Query: 484 SALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMD 543
SALD ESE +VQ AL+K RTTIV+AHRL+T+ +AD IA G IVE+G H EL M
Sbjct: 559 SALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL-MK 617
Query: 544 PHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
G Y +L+ +Q E E +++ K ID S+ R S +R S
Sbjct: 618 EKGIYFKLVTMQTAGNEVELENAADESK----SEIDALEMSSNDSRSSLIR------KRS 667
Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
R S + D + + + P + S WR+ KLN E P ++G A++NG
Sbjct: 668 TRRSVRGSQAQDRKLSTKEALDESIPPV----SFWRIMKLNLTEWPYFVVGVFCAIINGG 723
Query: 664 VFPIFGFLFSAVISMFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGK 721
+ P F +FS +I +F + PE +R+ S +SL+++ LG+++ + F L+ + FG AG
Sbjct: 724 LQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEI 783
Query: 722 LIERIRSLTFAKIVHQEIRWFDDPAHSS 749
L +R+R + F ++ Q++ WFDDP +++
Sbjct: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTT 811
Score = 354 bits (908), Expect = 8e-97
Identities = 214/598 (35%), Positives = 327/598 (53%), Gaps = 54/598 (9%)
Query: 14 STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
ST++ ++++ V F+++ + + ++G A+ NG P ++ K+I F
Sbjct: 683 STKEALDESIPPVSFWRIMKL-NLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 741
Query: 74 SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
+ E Q S + SLLF+ L I S IT FLQ + GE + R+R + +++L+QD+
Sbjct: 742 IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
Query: 133 AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
++FD NT G + +R++ D ++ A+G ++ Q + G +I+FI GW+L L+L
Sbjct: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
Query: 192 LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
LA VP I +AG +++ A++ + AG +A + + + RTV S T E+K Y
Sbjct: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYA 921
Query: 252 SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
+++ Y ++++ GI +++ SY +G+ LV K + V+ V A+
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV 981
Query: 312 VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
V G+M++GQ S +A K +A + I++ P ID+Y T GL+ ++G++ +V
Sbjct: 982 VFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVV 1041
Query: 372 FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
F YP RPD+ + G SL V G T ALVG SG GKSTV+ LLERFYDP AG+VL+DG +
Sbjct: 1042 FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1101
Query: 432 KNLQLRWIREQIGLVSQE------------------------------------------ 449
K L ++W+R +G+VSQE
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESL 1161
Query: 450 --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K
Sbjct: 1162 PNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1221
Query: 502 ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
RT IV+AHRL+TI +AD I V Q G++ E GTH +L + G Y ++ +Q G K
Sbjct: 1222 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL-LAQKGIYFSMVSVQAGTK 1278
Score = 322 bits (824), Expect = 4e-87
Identities = 168/328 (51%), Positives = 226/328 (68%), Gaps = 2/328 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV H+ +F ++ VF ++ AM+V Q S+ PD KA SAA I
Sbjct: 949 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P IDS S +G+ T+ GN+ V F+YPTRPDI + + L+L + +T+AL
Sbjct: 1009 IMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1068
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G+VLLDG +IK + WLR +G+V QEPILF+ SI
Sbjct: 1069 VGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIA 1128
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG +++EI+ AA AN H FI SLP+ Y T VG++GTQLSGGQKQRIAIAR
Sbjct: 1129 ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIAR 1188
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I V +N
Sbjct: 1189 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1248
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
G V E G H +L+ G+Y S+V++ +
Sbjct: 1249 GRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1275
Score = 317 bits (811), Expect = 1e-85
Identities = 164/330 (49%), Positives = 224/330 (67%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ G+ LV + + ++ VFFS+ + A SV Q+S A +A I
Sbjct: 306 IYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEI 365
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F I+D+KP IDS S G + + GN+E ++V+FSYP+R +++I K L L + S +TVAL
Sbjct: 366 FKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVAL 425
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + L++R YDP G V +DG DI+T + +LR+ +G+V QEP+LF +I
Sbjct: 426 VGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIA 485
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+E+ T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIAIARA
Sbjct: 486 ENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA +G
Sbjct: 545 LVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDG 604
Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
++ EKG HDELM G+Y LV + + +
Sbjct: 605 VIVEKGNHDELMKE-KGIYFKLVTMQTAGN 633
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1281
Score = 495 bits (1275), Expect = e-139
Identities = 295/811 (36%), Positives = 456/811 (55%), Gaps = 98/811 (12%)
Query: 12 SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
S+ + K N I P LF ++D D M++GTI A+A+G PLM ++ G++ + F
Sbjct: 27 SNQGRNKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 72 GSS---------------NQSEVLNQVSKVSLLFVYLAIGSGI--TSFLQVSCWMVTGER 114
++ N +L + + Y +G G+ +++QVS W + R
Sbjct: 86 VNNAGNFSLPVNFSLSMINPGRILEE-EMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGR 144
Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
Q +IR + IL+Q++ +FD + T E+ +R++ D I E +G+KVG F Q +TFF
Sbjct: 145 QIKKIRQNFFHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
GF++ FI+GW+L LV++A P + ++ A A +++ + + AYA+AG VA + +G++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 263
Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
RTV +F G+ K +E+Y ++ A ++++I++ I MG L+I+ SY LA WYGS LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
I+K Y G MTV +++ G+ S+GQ +P + AFA + AAY +F+ I PKID++
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
G + IKG+++ DVHF YP+R +++I G +L V SG T ALVG SG GK+T + LL+
Sbjct: 384 GHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQ 443
Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
R YDP G + IDG +++N +R++RE IG+VSQE
Sbjct: 444 RLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIK 503
Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
+ G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
D ESE VQ AL+K RTTIV+AHRL+T+ +AD IA + G IVE+G+HSEL M G
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MQKEG 622
Query: 547 AYSQLIRLQEG-------EKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQT 599
Y +L+ +Q E E E S D N H+ +ST++ S
Sbjct: 623 VYFKLVNMQTSGSQILSQEFEVELSEEKAADGMTPN-GWKSHIFRNSTKK-------SLK 674
Query: 600 SSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAM 659
SS +H H +++ ++D N P S ++ KLNK E P ++GT+ A+
Sbjct: 675 SSRAHHHR--------LDVDADELDANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAI 721
Query: 660 VNGVVFPIFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTA 718
VNG + P + S +I++F + ++++ +SLV++GLG+++ F L+ + FG A
Sbjct: 722 VNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKA 781
Query: 719 GGKLIERIRSLTFAKIVHQEIRWFDDPAHSS 749
G L R+RS+ F ++ Q++ WFDD +S+
Sbjct: 782 GEILTTRLRSMAFKAMLRQDMSWFDDYKNST 812
Score = 348 bits (893), Expect = 4e-95
Identities = 210/587 (35%), Positives = 316/587 (53%), Gaps = 53/587 (9%)
Query: 26 VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSK 85
V F K+ ++ + ++GT+ A+ NG P ++++L ++I FG + + + +
Sbjct: 697 VSFLKVLKL-NKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNL 755
Query: 86 VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEV 144
SL+F+ L + S T FLQ + GE + R+RS+ K +L+QD+++FD N TG +
Sbjct: 756 FSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGAL 815
Query: 145 ISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAF 204
+R++ D +Q A G ++ Q + G +I+FI GW+L L+LL+ VP I V+G
Sbjct: 816 STRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIV 875
Query: 205 MAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQ 264
++A A R + A AG +A + + ++RTV S T E+K Y K+ Y VQ
Sbjct: 876 EMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQM 935
Query: 265 SIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPS 324
+ GI ++ SY +G+ L++ V+ V A+V G+++LG S
Sbjct: 936 AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 995
Query: 325 LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
+A K +A +F +R+P ID+Y GL + +G + +V F YP R ++ +
Sbjct: 996 APDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQ 1055
Query: 385 GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
G SL V G T ALVG SG GKSTV+ LLERFYDP AG VL+DG K L ++W+R Q+G
Sbjct: 1056 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLG 1115
Query: 445 LVSQE--------------------------------------------------RQNGT 454
+VSQE GT
Sbjct: 1116 IVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGT 1175
Query: 455 QLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRL 514
QLSGGQKQR+AI RA+++ P++LLLDEATSALD ESE +VQEAL+K RT IV+AHRL
Sbjct: 1176 QLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1235
Query: 515 TTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
+TI +AD I V+Q GK+ E GTH +L + G Y ++ +Q G + +
Sbjct: 1236 STIQNADLIVVIQNGKVKEHGTHQQL-LAQKGIYFSMVNIQAGAQNS 1281
Score = 305 bits (782), Expect = 3e-82
Identities = 161/330 (48%), Positives = 220/330 (65%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ GS LV ++ T VFFS+ + A SV Q++ A +A I
Sbjct: 308 IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 367
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F+I+D+ P IDS S G +++ GN++ V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 368 FDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVAL 427
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GK+T + LL+R YDP G + +DG DI+ F + +LR+ +G+V QEP+LF+ +I
Sbjct: 428 VGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIA 487
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+ T +EI A ANA+ FI LP +DT VGERG QLSGGQKQRIAIARA
Sbjct: 488 ENIRYGR-GNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE VQ ALD+ RTT+++AHRL+T+R AD IA ++G
Sbjct: 547 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606
Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
++ E+G H ELM GVY LV + ++ S
Sbjct: 607 VIVEQGSHSELMQK-EGVYFKLVNMQTSGS 635
Score = 304 bits (779), Expect = 7e-82
Identities = 157/330 (47%), Positives = 224/330 (67%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ L+ + F ++ VF ++ A+++ +S+ PD KA SAA +
Sbjct: 950 MYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1009
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F++ + +P IDS S +G+ + G++ V F+YPTR ++ + + L+L + +T+AL
Sbjct: 1010 FSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLAL 1069
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G VLLDG + K I WLR Q+G+V QEP+LF+ SI
Sbjct: 1070 VGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIA 1129
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG ++DEI+ AA AAN H FI +LP Y T VG++GTQLSGGQKQR+AI R
Sbjct: 1130 ENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRR 1189
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P++LLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1190 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1249
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHSTA 1078
G V E G H +L+ G+Y S+V + + A
Sbjct: 1250 GKVKEHGTHQQLLAQ-KGIYFSMVNIQAGA 1278
Score = 48.1 bits (113), Expect = 1e-04
Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 20/150 (13%)
Query: 614 VDANIEQGQVDN---NEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGF 670
V+ + E G + N N+K K+++ + + + +LLGTI A+ +G P+
Sbjct: 17 VEGDFELGSISNQGRNKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMI 76
Query: 671 LFSAVISMFYK-----------------PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
+F + F P +E ++ Y GLG LV ++
Sbjct: 77 VFGEMTDKFVNNAGNFSLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVS 136
Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
F+ A G+ I++IR F I+ QE+ WFD
Sbjct: 137 FWTLAAGRQIKKIRQNFFHAILRQEMGWFD 166
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1279
Score = 492 bits (1266), Expect = e-138
Identities = 289/804 (35%), Positives = 457/804 (55%), Gaps = 85/804 (10%)
Query: 12 SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
SS ++ K +++ LF ++D D M +GTI A+A+G PLM ++ G++ + F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 72 GSS---------------NQSEVLNQVSKVSLLFVYLAIGSGI--TSFLQVSCWMVTGER 114
+ N ++L + + Y +G+G+ +++QVS W + R
Sbjct: 86 VDTAGNFSFPVNFSLSLLNPGKILEE-EMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR 144
Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
Q +IR + IL+Q+I +FD T E+ +R++ D I E +G+KVG F Q +TFF
Sbjct: 145 QIRKIRQKFFHAILRQEIGWFDINDTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
GF++ FI+GW+L LV++A P + ++ A A +++ + + AYA+AG VA + +G++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
RTV +F G+ K +E+Y ++ A ++++I++ I MG L+I+ SY LA WYGS LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
I+K Y G MTV +++ G+ S+GQ +P + AFA + AAY +F+ I PKID++
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
G + IKG++E DVHF YP+R +V+I G +L V SG T ALVG SG GKST + L++
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
R YDP+ G + IDG +++N + ++RE IG+VSQE
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIK 503
Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
+ G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
D ESE VQ AL+K RTTIV+AHRL+T+ +AD IA + G IVE+G+HSEL M G
Sbjct: 564 DTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-MKKEG 622
Query: 547 AYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRH 606
Y +L+ +Q + + SE + D MA + + R ++ + ++
Sbjct: 623 VYFKLVNMQTSGSQIQ----SEEFELNDE-KAATRMAPNGWKS----RLFRHSTQKNLKN 673
Query: 607 SQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFP 666
SQ+ + +D +E ++ N P S ++ KLNK E P ++GT+ A+ NG + P
Sbjct: 674 SQMCQKSLD--VETDGLEANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAIANGGLQP 726
Query: 667 IFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIER 725
F +FS +I++F + ++++ +SL+++ LG+++ F L+ + FG AG L R
Sbjct: 727 AFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRR 786
Query: 726 IRSLTFAKIVHQEIRWFDDPAHSS 749
+RS+ F ++ Q++ WFDD +S+
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNST 810
Score = 350 bits (897), Expect = 2e-95
Identities = 215/583 (36%), Positives = 315/583 (53%), Gaps = 53/583 (9%)
Query: 26 VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSK 85
V F K+ ++ + ++GT+ A+ANG P +++ ++I FG + + + +
Sbjct: 695 VSFLKVLKL-NKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNI 753
Query: 86 VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEV 144
SL+F++L I S T FLQ + GE + R+RS+ K +L+QD+++FD N TG +
Sbjct: 754 FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGAL 813
Query: 145 ISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAF 204
+R++ D +Q A G ++ Q + G +I+FI GW+L L+LLA VP I V+G
Sbjct: 814 STRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIV 873
Query: 205 MAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQ 264
++A A R + AG +A + + ++RTV S T E+K Y K+ Y VQ+
Sbjct: 874 EMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQK 933
Query: 265 SIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPS 324
+ GI ++ SY +G+ L++ V+ V A+V G+++LG S
Sbjct: 934 AHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSF 993
Query: 325 LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
+A K +A +F +R+P ID+Y GL + +G+I +V F YP R +V +
Sbjct: 994 APDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQ 1053
Query: 385 GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
G SL V G T ALVG SG GKSTV+ LLERFYDP AG VL+DG K L ++W+R Q+G
Sbjct: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLG 1113
Query: 445 LVSQE--------------------------------------------------RQNGT 454
+VSQE GT
Sbjct: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173
Query: 455 QLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRL 514
QLSGGQKQRIAIARA+++ P+ILLLDEATSALD ESE +VQEAL+K RT IV+AHRL
Sbjct: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1233
Query: 515 TTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEG 557
+TI +AD I V Q G++ E GTH +L + G Y ++ +Q G
Sbjct: 1234 STIQNADLIVVFQNGRVKEHGTHQQL-LAQKGIYFSMVSVQAG 1275
Score = 310 bits (793), Expect = 2e-83
Identities = 162/330 (49%), Positives = 222/330 (67%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ GS LV ++ T VFFS+ + A SV Q++ A +A I
Sbjct: 308 IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 367
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F+I+D+ P IDS S G +++ GN+E V+FSYP+R +++I K L L + S +TVAL
Sbjct: 368 FDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVAL 427
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + L++R YDP+ G + +DG DI+ F +++LR+ +G+V QEP+LF+ +I
Sbjct: 428 VGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIA 487
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+ T DEI A ANA+ FI LP +DT VGERG QLSGGQKQRIAIARA
Sbjct: 488 ENICYGR-GNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE VQ ALD+ RTT+++AHRL+T+R AD IA ++G
Sbjct: 547 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606
Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
++ E+G H ELM GVY LV + ++ S
Sbjct: 607 VIVEQGSHSELMKK-EGVYFKLVNMQTSGS 635
Score = 309 bits (791), Expect = 3e-83
Identities = 160/328 (48%), Positives = 225/328 (67%), Gaps = 2/328 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ L+ + F ++ VF ++ A+++ +S+ PD KA SAA +
Sbjct: 948 MYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F + + +P IDS S +G+ + GNI V F+YPTR ++ + + L+L + +T+AL
Sbjct: 1008 FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1067
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G VLLDG + K + WLR Q+G+V QEPILF+ SI
Sbjct: 1068 VGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1127
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG ++DEI++AA AAN H FI +LP Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1128 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1187
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P+ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I V +N
Sbjct: 1188 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1247
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
G V E G H +L+ G+Y S+V++ +
Sbjct: 1248 GRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1274
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 491 bits (1265), Expect = e-138
Identities = 291/791 (36%), Positives = 449/791 (55%), Gaps = 90/791 (11%)
Query: 26 VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSS----------N 75
V + +F +AD LD M +GT++A+ +G PL+ L+ G + ++F S N
Sbjct: 32 VGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN 91
Query: 76 QSEV--LNQVSKVSL-------LFVYLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYL 124
QSE+ + VS SL + Y IG+G I +++QVS W + RQ +IR +
Sbjct: 92 QSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFF 151
Query: 125 KTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKG 184
I+ Q+I +FD + GE+ +R++ D I + +G+K+G F Q +TF GF+I FI G
Sbjct: 152 HAIMNQEIGWFDVN-DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISG 210
Query: 185 WRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEK 244
W+L LV+LA P I ++ A A V+ + AYA+AG VA + + ++RTV +F G+K
Sbjct: 211 WKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQK 270
Query: 245 KAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTV 304
K +E+YN ++ A ++++I + I +G L+++ SY LA WYG+ LV++ Y+ G V
Sbjct: 271 KELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQV 330
Query: 305 MTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGD 364
+TV +++ G+ S+G +P++ AFA + AAY++F+ I +P ID++ T G + I G+
Sbjct: 331 LTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGN 390
Query: 365 IELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEV 424
+E ++V+F YP+R +V+I G +L V SG T ALVG SG GKST + LL+R YDP GEV
Sbjct: 391 LEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEV 450
Query: 425 LIDGVNLKNLQLRWIREQIGLVSQE---------------RQN----------------- 452
IDG +++ + +R++RE IG+VSQE R+N
Sbjct: 451 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 510
Query: 453 ----------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQE 496
G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ
Sbjct: 511 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 570
Query: 497 ALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
AL+K RTTIV+AHRL+T+ +AD IA G IVE+G H EL M G Y +L+ Q
Sbjct: 571 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MKEKGIYFKLVMTQT 629
Query: 557 GEKEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVD 615
E E G+ + E + + S R S RSI + R S S E VD
Sbjct: 630 RGNEIEPGNNAYESQSDTGASELTSEESKSPLIRRSIRRSIHRRQDQERRLS--SKEDVD 687
Query: 616 ANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAV 675
++ S W++ KLN E P +++G + A++NG + P+F +FS +
Sbjct: 688 EDVPM--------------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKI 733
Query: 676 ISMFYKPPEQQRKE--SRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAK 733
+ +F + + + K+ +SL+++ +G+++ V + + + FG AG L +R+R + F
Sbjct: 734 VGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKS 793
Query: 734 IVHQEIRWFDD 744
++ Q+I WFDD
Sbjct: 794 MLRQDISWFDD 804
Score = 318 bits (815), Expect = 5e-86
Identities = 198/602 (32%), Positives = 320/602 (52%), Gaps = 59/602 (9%)
Query: 14 STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
S+++ V++ +V F+++ + + +++G + A+ NG P+ ++ K++ F
Sbjct: 681 SSKEDVDEDVPMVSFWQILKL-NISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSR 739
Query: 74 SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
+ E + + SLLF+ + + S +T F Q + GE + R+R + K++L+QDI
Sbjct: 740 DDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDI 799
Query: 133 AFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIK--GWRLAL 189
++FD NT G + +R++ D ++ AMG ++ Q + G +++ + GW+L L
Sbjct: 800 SWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTL 859
Query: 190 VLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEK 249
+L+ +P IV+ G +++ A++ + +G +A + + + RTV S T E+K
Sbjct: 860 LLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETM 919
Query: 250 YNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVI 309
Y ++I Y ++++ GI +I+ SY +G+ LV + VM V
Sbjct: 920 YAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFS 979
Query: 310 ALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRD 369
A+V G+M+ G TS +A K +A + I++ P+ID+Y T GL ++G+++
Sbjct: 980 AVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNG 1039
Query: 370 VHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGV 429
V F YP RP++ + G S V G T LVG SG GKSTV+ LLERFY+P AG V +DG
Sbjct: 1040 VKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGK 1099
Query: 430 NLKNLQLRWIREQIGLVSQE---------------------------------------- 449
+K L ++ +R +G+VSQE
Sbjct: 1100 EIKQLNVQCVR-ALGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFID 1158
Query: 450 ----------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALE 499
GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+
Sbjct: 1159 SLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1218
Query: 500 KIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEK 559
K RT +V+AHRL+TI +AD I V+Q G++ E GTH +L + G Y ++ Q G K
Sbjct: 1219 KAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQL-LAQKGIYFSMV--QAGAK 1275
Query: 560 EA 561
+
Sbjct: 1276 RS 1277
Score = 305 bits (780), Expect = 6e-82
Identities = 158/327 (48%), Positives = 220/327 (66%), Gaps = 2/327 (0%)
Query: 746 AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
A+ +Y + A F+ G+ LV + + ++ VFFS+ + S+ + A +
Sbjct: 301 AYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGA 360
Query: 806 AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
A IF I+D++P IDS S G ++++GN+E ++V F+YP+R +++I K L L + S +
Sbjct: 361 AYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQ 420
Query: 866 TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
TVALVG SG GKST + LL+R YDP G V +DG DI+T + +LR+ +G+V QEP+LF
Sbjct: 421 TVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480
Query: 926 ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
+I NI YG+E+ T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIA
Sbjct: 481 TTIAENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 539
Query: 986 IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
IARA+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA
Sbjct: 540 IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599
Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLV 1072
G++ E+G H+ELM G+Y LV
Sbjct: 600 FDGGVIVEQGNHEELMKE-KGIYFKLV 625
Score = 298 bits (763), Expect = 5e-80
Identities = 159/324 (49%), Positives = 216/324 (66%), Gaps = 3/324 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV TF + VF ++ AM+ +S+ PD KA SA+ I
Sbjct: 949 IYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHI 1008
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P+IDS S +G+ + GN++ V F+YPTRP+I + + L+ + +T+ L
Sbjct: 1009 IGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRL 1068
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFY+P +G V LDG +IK + +R +G+V QEPILF+ SI
Sbjct: 1069 VGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQEPILFDCSIA 1127
Query: 930 ANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG + +EI+ AA AN H FI SLP+ Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1128 ENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIAR 1187
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT V++AHRL+TI+ AD I VI+N
Sbjct: 1188 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADLIVVIQN 1247
Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
G V E G H +L+ G+Y S+V
Sbjct: 1248 GQVKEHGTHQQLLAQ-KGIYFSMV 1270
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 491 bits (1263), Expect = e-138
Identities = 286/795 (35%), Positives = 445/795 (55%), Gaps = 89/795 (11%)
Query: 26 VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGSSNQS---EVLNQ 82
V + +F +AD LD MI+GT++A+ +G PL+ L+ G + ++F + S + NQ
Sbjct: 33 VGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQ 92
Query: 83 VSKVSLLFV---------------YLAIGSG--ITSFLQVSCWMVTGERQSARIRSLYLK 125
S L + Y IG+G I +++QVS W + RQ +IR +
Sbjct: 93 SGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFH 152
Query: 126 TILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGW 185
I+ Q+I +FD + GE+ +R++ D I + +G+K+G F Q +TF GF+I FI GW
Sbjct: 153 AIMNQEIGWFDVH-DVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGW 211
Query: 186 RLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKK 245
+L LV+LA P I ++ A A V+ + AYA+AG VA + + ++RTV +F G++K
Sbjct: 212 KLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQK 271
Query: 246 AIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVM 305
+E+YN ++ A ++++I + I +G L+++ SY LA WYG+ LV++ Y+ G V+
Sbjct: 272 ELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVL 331
Query: 306 TVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDI 365
TV +++ G+ S+G +P++ AFA + AA+++F+ I +P ID++ T G + I G++
Sbjct: 332 TVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNL 391
Query: 366 ELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVL 425
E ++VHF YP+R +V+I G +L V SG T ALVG SG GKST + L++R YDP G V
Sbjct: 392 EFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVS 451
Query: 426 IDGVNLKNLQLRWIREQIGLVSQE------------------------------------ 449
IDG +++ + +R++RE IG+VSQE
Sbjct: 452 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF 511
Query: 450 ------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEA 497
+ G QLSGGQKQRIAIARA+++NPKILLLDEATSALD ESE +VQ A
Sbjct: 512 IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 571
Query: 498 LEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEG 557
L+K RTTIV+AHRL+T+ +AD IA G IVE+G H EL M G Y +L+ Q
Sbjct: 572 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDEL-MREKGIYFKLVMTQTR 630
Query: 558 EKEAE-GSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDA 616
E E G+ + D + + S R S RS+ + R S E VD
Sbjct: 631 GNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSM--KEAVDE 688
Query: 617 NIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVI 676
++ P + S WR+ LN E P +L+G + A++NG + P+F +FS ++
Sbjct: 689 DV----------PLV----SFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIV 734
Query: 677 SMFYKPP--EQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKI 734
+F + E +R+ +SL ++ +GL++ V + + + FG AG L +R+R + F +
Sbjct: 735 GVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSM 794
Query: 735 VHQEIRWFDDPAHSS 749
+ Q+I WFDD +S+
Sbjct: 795 LRQDISWFDDHKNST 809
Score = 338 bits (866), Expect = 6e-92
Identities = 199/600 (33%), Positives = 322/600 (53%), Gaps = 56/600 (9%)
Query: 14 STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAFGS 73
S ++ V++ +V F+++ + + + +++G + A+ NG P+ ++ +++ F
Sbjct: 681 SMKEAVDEDVPLVSFWRILNL-NLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSR 739
Query: 74 SNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDI 132
+ E Q + SL F+ + + S +T F Q + GE + R+R + K++L+QDI
Sbjct: 740 DDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDI 799
Query: 133 AFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVL 191
++FD N TG + +R++ D ++ AMG ++ Q + G +++ + GW+L L+L
Sbjct: 800 SWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLL 859
Query: 192 LACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYN 251
+ +P IV+ G +++ A++ + +G +A + + + RT+ S T E+K Y
Sbjct: 860 VVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYA 919
Query: 252 SKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIAL 311
+++ Y ++++ GI +++ SY +G+ LV + VM V A+
Sbjct: 920 QSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAV 979
Query: 312 VTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVH 371
V G+M+ G TS +A K +A + I++ P+ID+Y T GL ++G+++ V
Sbjct: 980 VFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQ 1039
Query: 372 FRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNL 431
F YP RP++ + G SL V G T ALVG SG GKSTV+ LLERFYDP AG V +DG +
Sbjct: 1040 FNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEI 1099
Query: 432 KNLQLRWIREQIGLVSQE------------------------------------------ 449
K L ++W+R +G+VSQE
Sbjct: 1100 KQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSL 1159
Query: 450 --------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKI 501
GTQLSGGQKQRIAIARA+++ P ILLLDEATSALD ESE +VQEAL+K
Sbjct: 1160 PDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA 1219
Query: 502 ILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEA 561
RT IV+AHRL+TI +AD I V++ GK+ E GTH +L + G Y ++ Q G K +
Sbjct: 1220 REGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQL-LAQKGIYFSMV--QAGAKRS 1276
Score = 318 bits (814), Expect = 6e-86
Identities = 165/324 (50%), Positives = 221/324 (67%), Gaps = 2/324 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV + TF + VF ++ AM+ +S+ PD KA SA+ I
Sbjct: 947 MYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHI 1006
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P+IDS S +G+ + GN++ V F+YPTRP+I + + L+L + +T+AL
Sbjct: 1007 IRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLAL 1066
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G V LDG +IK + WLR +G+V QEPILF+ SI
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIA 1126
Query: 930 ANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG A + +EI+ AA AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 ENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1186
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1187 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIEN 1246
Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
G V E G H +L+ G+Y S+V
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMV 1269
Score = 311 bits (796), Expect = 8e-84
Identities = 161/327 (49%), Positives = 221/327 (67%), Gaps = 2/327 (0%)
Query: 746 AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
A+ +Y + A F+ G+ LV + + E+ VFFS+ + S+ + A +
Sbjct: 301 AYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGA 360
Query: 806 AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
A IF I+D++P IDS S G ++++GN+E ++V+F+YP+R ++QI K L L + S +
Sbjct: 361 AFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQ 420
Query: 866 TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
TVALVG SG GKST + L++R YDP G V +DG DI+T + +LR+ +G+V QEP+LF
Sbjct: 421 TVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480
Query: 926 ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
+I NI YG+ED T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIA
Sbjct: 481 TTIAENIRYGRED-VTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIA 539
Query: 986 IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
IARA+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA
Sbjct: 540 IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599
Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLV 1072
G++ E+G HDELM G+Y LV
Sbjct: 600 FDGGVIVEQGNHDELMRE-KGIYFKLV 625
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 490 bits (1262), Expect = e-138
Identities = 292/804 (36%), Positives = 454/804 (56%), Gaps = 83/804 (10%)
Query: 11 SSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINA 70
S S+ + K ++ LF ++D D M +GT+ A+A+G PLM ++ G++ +
Sbjct: 22 SISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDK 81
Query: 71 FGSSNQSEVLNQVSKVSLL--------------FVYLAIGSGI--TSFLQVSCWMVTGER 114
F + + L +S+L + Y +G G+ +++QVS W + R
Sbjct: 82 FVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGR 141
Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
Q +IR + IL+Q++ +FD + T E+ +R++ D I E +G+KVG F Q +TFF
Sbjct: 142 QIKKIRQKFFHAILRQEMGWFDIKGTT-ELNTRLTDDVSKISEGIGDKVGMFFQAIATFF 200
Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
GF++ FI+GW+L LV++A P + ++ A A +++ + + AYA+AG VA + G++
Sbjct: 201 AGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAI 260
Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
RTV +F G+ K +E+Y ++ A ++++I++ I MG L+I+ SY LA WYGS LV
Sbjct: 261 RTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 320
Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
I+K Y G MTV +++ G+ S+GQ +P + AFA + AAY +F+ I PKID++
Sbjct: 321 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 380
Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
G ++IKG++E DVHF YP+R +++I G +L V SG T ALVG SG GKST + LL+
Sbjct: 381 GHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQ 440
Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------- 449
R YDP G++ IDG +++N +R +RE IG+VSQE
Sbjct: 441 RLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIE 500
Query: 450 -----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 501 KAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560
Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
D ESE VQ AL+K RTTIV+AHRL+TI +AD IA + G IVE+G+HSEL M G
Sbjct: 561 DTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSEL-MKKEG 619
Query: 547 AYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRH 606
Y +L+ +Q + S EV+ + D+ G + R+ ++ S S
Sbjct: 620 IYFRLVNMQTAGSQIL-SEEFEVELSDEKAAGDVAPNG---WKARIFRNSTKKSLKSPHQ 675
Query: 607 SQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFP 666
++L + E ++D N P S ++ KLNK E P ++GT+ A+ NG + P
Sbjct: 676 NRL-------DEETNELDANVPPV-----SFLKVLKLNKTEWPYFVVGTVCAIANGALQP 723
Query: 667 IFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIER 725
F + S +I++F + ++++ +SLV++GLG+++ F L+ + FG AG L R
Sbjct: 724 AFSIILSEMIAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTR 783
Query: 726 IRSLTFAKIVHQEIRWFDDPAHSS 749
+RS+ F ++ Q++ WFDD +S+
Sbjct: 784 LRSMAFKAMLRQDMSWFDDHKNST 807
Score = 354 bits (909), Expect = 6e-97
Identities = 216/601 (35%), Positives = 320/601 (52%), Gaps = 53/601 (8%)
Query: 8 HENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKV 67
H+N ++ V F K+ ++ + ++GT+ A+ANG P +++L ++
Sbjct: 674 HQNRLDEETNELDANVPPVSFLKVLKL-NKTEWPYFVVGTVCAIANGALQPAFSIILSEM 732
Query: 68 INAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTI 127
I FG + + + + SL+F+ L + S T FLQ + GE + R+RS+ K +
Sbjct: 733 IAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAM 792
Query: 128 LKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWR 186
L+QD+++FD N TG + +R++ D +Q A G K+ Q + G +I+FI GW+
Sbjct: 793 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQ 852
Query: 187 LALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKA 246
L L+LL+ VP I VAG ++A A R + AG +A + + ++RTV S T E+K
Sbjct: 853 LTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKF 912
Query: 247 IEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVMT 306
Y K+ Y V+++ GI ++ SY +GS L++ V+
Sbjct: 913 ESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVIL 972
Query: 307 VVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIE 366
V A+V G+++LG S +A K +A +F +R+P ID+Y GL + +G +
Sbjct: 973 VFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVT 1032
Query: 367 LRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLI 426
+V F YP R +V + G SL V G T ALVG SG GKSTV+ LLERFYDP AG VL+
Sbjct: 1033 FNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLL 1092
Query: 427 DGVNLKNLQLRWIREQIGLVSQE------------------------------------- 449
DG K L ++W+R Q+G+VSQE
Sbjct: 1093 DGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHP 1152
Query: 450 -------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQE 496
GTQLSGGQKQRIAIARA+++ P++LLLDEATSALD ESE +VQE
Sbjct: 1153 FIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQE 1212
Query: 497 ALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
AL+K RT IV+AHRL+TI +AD I V++ GK+ E GTH +L + G Y ++ +Q
Sbjct: 1213 ALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQL-LAQKGIYFSMVNIQA 1271
Query: 557 G 557
G
Sbjct: 1272 G 1272
Score = 307 bits (787), Expect = 9e-83
Identities = 163/330 (49%), Positives = 219/330 (65%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ GS LV ++ T VFFS+ + A SV Q++ A +A I
Sbjct: 305 IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVI 364
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F+I+D+ P IDS S G + + GN+E V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 365 FDIIDNNPKIDSFSERGHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVAL 424
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + LL+R YDP G++ +DG DI+ F + LR+ +G+V QEP+LF+ +I
Sbjct: 425 VGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIA 484
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+ T DEI A ANA++FI LP +DT VG+RG QLSGGQKQRIAIARA
Sbjct: 485 ENIRYGR-GNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARA 543
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE VQ ALD+ RTT+++AHRL+TIR AD IA ++G
Sbjct: 544 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDG 603
Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
++ E+G H ELM G+Y LV + + S
Sbjct: 604 VIVEQGSHSELMKK-EGIYFRLVNMQTAGS 632
Score = 306 bits (785), Expect = 1e-82
Identities = 158/328 (48%), Positives = 223/328 (67%), Gaps = 2/328 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F GS L+ + F ++ VF ++ + A+++ +S+ PD KA SAA +
Sbjct: 945 MYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYL 1004
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F++ + +P IDS S +G+ + G++ V F+YPTR ++ + + L+L + +T+AL
Sbjct: 1005 FSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1064
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G VLLDG + K + WLR Q+G+V QEPILF+ SI
Sbjct: 1065 VGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1124
Query: 930 ANIAYGKEDGAT-EDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG DEI+ AA AN H FI +LP Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1125 ENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIAR 1184
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P++LLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1185 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIEN 1244
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
G V E G H +L+ G+Y S+V + +
Sbjct: 1245 GKVKEHGTHQQLLAQ-KGIYFSMVNIQA 1271
Score = 46.2 bits (108), Expect = 5e-04
Identities = 37/150 (24%), Positives = 60/150 (39%), Gaps = 20/150 (13%)
Query: 614 VDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELP---VILLGTIAAMVNGVVFPIFGF 670
+D + E G + N + K N I L + + LGT+ A+ +G P+
Sbjct: 14 LDGDFELGSISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMI 73
Query: 671 LFSAVISMFY-----------------KPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
+F + F P +E ++ Y GLG LV ++
Sbjct: 74 VFGEMTDKFVDNTGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVS 133
Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
F+ A G+ I++IR F I+ QE+ WFD
Sbjct: 134 FWTLAAGRQIKKIRQKFFHAILRQEMGWFD 163
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 490 bits (1262), Expect = e-138
Identities = 285/808 (35%), Positives = 452/808 (55%), Gaps = 92/808 (11%)
Query: 14 STQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF-- 71
S ++ K N V + +F +AD LD M++GT++A+ +G + PL+ L+ G + ++F
Sbjct: 22 SKKEKKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTK 81
Query: 72 -------GSSNQSEVLN--------QVSKVSLLFVYLAIGSG--ITSFLQVSCWMVTGER 114
+NQSE+ N + + + Y IG+G I +++QVS W + R
Sbjct: 82 AETSIWPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGR 141
Query: 115 QSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFF 174
Q +IR + I+ Q+I +FD + GE+ +R++ D I + +G+K+G F Q +TF
Sbjct: 142 QINKIRQKFFHAIMNQEIGWFDVH-DIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFL 200
Query: 175 GGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSM 234
F++ FI GW+L LV+LA P I ++ A A V+ + AYA+AG VA + + ++
Sbjct: 201 AAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAI 260
Query: 235 RTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLV 294
RTV +F G+ K +E+YN ++ A +++++ + I +G L+++ SY LA WYG+ LV
Sbjct: 261 RTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLV 320
Query: 295 IAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTS 354
++ Y+ G V+TV +++ G+ S+G +P++ FA + AAY++F+ I +P ID++ T
Sbjct: 321 LSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQ 380
Query: 355 GLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLE 414
G + + G++E ++VHF YP+R ++I G +L V SG T ALVG+SG GKST + LL+
Sbjct: 381 GHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQ 440
Query: 415 RFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------RQN------- 452
R YDP G V IDG +++ + +R++RE IG+VSQE R+N
Sbjct: 441 RLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIE 500
Query: 453 --------------------------GTQLSGGQKQRIAIARAILKNPKILLLDEATSAL 486
G QLSGGQKQRIAIARA+++NPKILLLDEATSAL
Sbjct: 501 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 560
Query: 487 DAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHG 546
D ESE +VQ AL+K RTTIV+AHRL+T+ +AD IA G IVE+G H EL M G
Sbjct: 561 DTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEEL-MKEKG 619
Query: 547 AYSQLIRLQEGEKEAE-GSRS--SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
Y +L+ +Q E E GS + S+ D L + S + R S RSI +
Sbjct: 620 IYCRLVMMQTRGNEVELGSEADGSQSDTIASELTSEEFK--SPSVRKSTCRSICGSQDQE 677
Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
R S + D + S W + KLN E P +++G + A++NG
Sbjct: 678 RRVSVKEAQDEDVPLV----------------SFWGILKLNITEWPYLVVGVLCAVINGC 721
Query: 664 VFPIFGFLFSAVISMFYK--PPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGK 721
+ P+F +FS +I +F + P+ +++ +SL ++ +G++ V + + + FG AG
Sbjct: 722 MQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEI 781
Query: 722 LIERIRSLTFAKIVHQEIRWFDDPAHSS 749
L +R+R + F ++ Q+I WFDD +S+
Sbjct: 782 LTKRLRYMVFKSMLRQDISWFDDHRNST 809
Score = 328 bits (840), Expect = 6e-89
Identities = 192/563 (34%), Positives = 301/563 (53%), Gaps = 53/563 (9%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKV-SLLFVYLAIGSGITS 101
+++G + A+ NG P+ +++ +I F + + Q + SL F+ + + +T
Sbjct: 709 LVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTY 768
Query: 102 FLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMG 160
F Q + GE + R+R + K++L+QDI++FD N TG + +R++ D ++ AM
Sbjct: 769 FFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMS 828
Query: 161 EKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAY 220
++ Q + G +I+ + GW+L L+L+ P I+++G V++ A++ +
Sbjct: 829 SRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKEL 888
Query: 221 AEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIF 280
+G +A + + + RTV S T E+K Y ++I Y ++++ GI +++
Sbjct: 889 EVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMY 948
Query: 281 CSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFE 340
SY +G+ LV + VM V A+V G+++ G S +A K +A +
Sbjct: 949 FSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIR 1008
Query: 341 TIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVG 400
+++ P ID+Y T GL ++G+++ +V F YP RPD+ + G SL V G T ALVG
Sbjct: 1009 IMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVG 1068
Query: 401 QSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE----------- 449
SG GKSTV+ LLERFYDP AG V +DG +K L ++W+R +G+VSQE
Sbjct: 1069 SSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAEN 1128
Query: 450 ---------------------------------------RQNGTQLSGGQKQRIAIARAI 470
GTQLSGGQKQRIAIARA+
Sbjct: 1129 IAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARAL 1188
Query: 471 LKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGK 530
++ P ILLLDEATSALD ESE +VQEAL+K RT IV+AHRL+TI +AD I V+Q GK
Sbjct: 1189 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGK 1248
Query: 531 IVERGTHSELTMDPHGAYSQLIR 553
+ E GTH +L + G Y +++
Sbjct: 1249 VKEHGTHQQL-LAQKGIYFSMVQ 1270
Score = 316 bits (809), Expect = 2e-85
Identities = 166/324 (51%), Positives = 219/324 (67%), Gaps = 2/324 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F G+ LV H+ TF + VF ++ A++ +S+ PD KA SA+ I
Sbjct: 947 MYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHI 1006
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
I++ P IDS S G+ + GN++ V F+YPTRPDI + + L+L + +T+AL
Sbjct: 1007 IRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLAL 1066
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G V LDG +IK + WLR +G+V QEPILF+ SI
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIA 1126
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG ++DEI AA AN H FI SLPD Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 ENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIAR 1186
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P ILLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI+N
Sbjct: 1187 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQN 1246
Query: 1049 GMVAEKGRHDELMNNTHGVYASLV 1072
G V E G H +L+ G+Y S+V
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMV 1269
Score = 307 bits (786), Expect = 1e-82
Identities = 161/331 (48%), Positives = 222/331 (66%), Gaps = 2/331 (0%)
Query: 746 AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
A+ +Y + A F+ G+ LV + + ++ VFFS+ S+ + A +
Sbjct: 301 AYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGA 360
Query: 806 AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
A IF I+D++P IDS S G ++V+GN+E ++V+FSYP+R I+I K L L + S +
Sbjct: 361 AYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQ 420
Query: 866 TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
TVALVG+SG GKST + LL+R YDP G V +DG DI+T + +LR+ +G+V QEP+LF
Sbjct: 421 TVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA 480
Query: 926 ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
+I NI YG+E+ T DEI A ANA++FI LP +DT VGERG QLSGGQKQRIA
Sbjct: 481 TTIAENIRYGREN-VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 539
Query: 986 IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
IARA+++NPKILLLDEATSALD ESE +VQ ALD+ RTT+++AHRL+T+R AD IA
Sbjct: 540 IARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 599
Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLVALHS 1076
G++ E+G H+ELM G+Y LV + +
Sbjct: 600 FDGGVIVEQGNHEELMKE-KGIYCRLVMMQT 629
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 483 bits (1242), Expect = e-135
Identities = 288/803 (35%), Positives = 450/803 (55%), Gaps = 82/803 (10%)
Query: 12 SSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF 71
S+ +++ K N I P LF ++D D M++GT A+A+G PLM ++ G++ + F
Sbjct: 24 SNQSREKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKF 82
Query: 72 GSSNQSEVLNQVSKVSLL--------------FVYLAIGSGI--TSFLQVSCWMVTGERQ 115
+ + L +S+L + Y +G G+ +++QVS W + RQ
Sbjct: 83 VDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQ 142
Query: 116 SARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFG 175
+IR + IL+Q++ +FD + T E+ +R++ D I E +G+KVG F Q +TFF
Sbjct: 143 IRKIRQKFFHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAIATFFA 201
Query: 176 GFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMR 235
GF++ FI+GW+L LV++A + ++ A A +++ + + AYA+AG VA + +G++R
Sbjct: 202 GFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIR 261
Query: 236 TVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVI 295
TV +F G+ K +E+Y ++ A ++++I++ I MG L+I+ SY LA WYGS LVI
Sbjct: 262 TVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI 321
Query: 296 AKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSG 355
+K Y G MTV +++ G+ S+GQ +P + AF + AAY +F+ I PKID++ G
Sbjct: 322 SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERG 381
Query: 356 LVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLER 415
+ IKG++E DVHF YP+R +++I G +L V SG T ALVG SG GKST + LL+R
Sbjct: 382 HKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQR 441
Query: 416 FYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE-------------------------- 449
YDP G + IDG +++N +R +RE IG+VSQE
Sbjct: 442 LYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKK 501
Query: 450 ----------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALD 487
G QLSGGQKQRIAIARA+++NPKILLLDEATSALD
Sbjct: 502 AVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 561
Query: 488 AESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGA 547
ESE VQ AL+K RTTIV+AHRL+T+ +AD IA + G IVE+G+HSEL + G
Sbjct: 562 TESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL-IKKEGI 620
Query: 548 YSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHS 607
Y +L+ +Q + S EV+ + + G + S SS +H++
Sbjct: 621 YFRLVNMQTSGSQIL-SEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNR 679
Query: 608 QLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPI 667
++E ++D N P S ++ +LNK E P ++GT+ A+ NG + P
Sbjct: 680 --------LDVETNELDANVPPV-----SFLKVLRLNKTEWPYFVVGTLCAIANGALQPA 726
Query: 668 FGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERI 726
F + S +I++F + ++++ +SLV++GLG+ + F L+ + FG AG L R+
Sbjct: 727 FSIILSEMIAIFGPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRL 786
Query: 727 RSLTFAKIVHQEIRWFDDPAHSS 749
RS+ F ++ Q++ WFDD +S+
Sbjct: 787 RSMAFKAMLRQDMSWFDDHKNST 809
Score = 352 bits (902), Expect = 4e-96
Identities = 214/605 (35%), Positives = 321/605 (52%), Gaps = 53/605 (8%)
Query: 4 NTEVHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLL 63
++ H+N ++ V F K+ ++ + ++GT+ A+ANG P +++
Sbjct: 672 SSRAHQNRLDVETNELDANVPPVSFLKVLRL-NKTEWPYFVVGTLCAIANGALQPAFSII 730
Query: 64 LGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLY 123
L ++I FG + + + + SL+F+ L + S T FLQ + GE + R+RS+
Sbjct: 731 LSEMIAIFGPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMA 790
Query: 124 LKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFI 182
K +L+QD+++FD N TG + +R++ D +Q A G ++ Q + G +I+FI
Sbjct: 791 FKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFI 850
Query: 183 KGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTG 242
GW+L L+LL+ VP I VAG ++A A R + AG +A + + ++RTV S T
Sbjct: 851 YGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQ 910
Query: 243 EKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGG 302
E+K Y K+ Y V+++ GI ++ SY +GS L++
Sbjct: 911 ERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFK 970
Query: 303 TVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIK 362
V+ V A+V G+++LG S +A K +A +F +R+P ID+Y G+ + +
Sbjct: 971 DVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFE 1030
Query: 363 GDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAG 422
G + +V F YP R +V + G SL V G T ALVG SG GKSTV+ LLERFYDP AG
Sbjct: 1031 GSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG 1090
Query: 423 EVLIDGVNLKNLQLRWIREQIGLVSQE--------------------------------- 449
VL+DG K L ++W+R Q+G+VSQE
Sbjct: 1091 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEA 1150
Query: 450 -----------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAESEH 492
GTQLSGGQKQRIAIARA+++ P++LLLDEATSALD ESE
Sbjct: 1151 NIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEK 1210
Query: 493 IVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLI 552
+VQEAL+K RT IV+AHRL+TI +AD I V+ GK+ E GTH +L + G Y ++
Sbjct: 1211 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQL-LAQKGIYFSMV 1269
Query: 553 RLQEG 557
+Q G
Sbjct: 1270 NIQAG 1274
Score = 307 bits (787), Expect = 9e-83
Identities = 158/328 (48%), Positives = 224/328 (68%), Gaps = 2/328 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F GS L+ + F ++ VF ++ + A+++ +S+ PD KA SAA +
Sbjct: 947 MYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYL 1006
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F++ + +P IDS S +G+ + G++ V F+YPTR ++ + + L+L + +T+AL
Sbjct: 1007 FSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1066
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKSTV+ LLERFYDP +G VLLDG + K + WLR Q+G+V QEPILF+ SI
Sbjct: 1067 VGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1126
Query: 930 ANIAYGKEDG-ATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIAR 988
NIAYG ++DEI+ AA AN H FI +LP Y+T VG++GTQLSGGQKQRIAIAR
Sbjct: 1127 KNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIAR 1186
Query: 989 AMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKN 1048
A+++ P++LLLDEATSALD ESE++VQEALD+ RT +++AHRL+TI+ AD I VI N
Sbjct: 1187 ALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDN 1246
Query: 1049 GMVAEKGRHDELMNNTHGVYASLVALHS 1076
G V E G H +L+ G+Y S+V + +
Sbjct: 1247 GKVKEHGTHQQLLAQ-KGIYFSMVNIQA 1273
Score = 305 bits (781), Expect = 4e-82
Identities = 161/330 (48%), Positives = 220/330 (65%), Gaps = 2/330 (0%)
Query: 750 LYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASI 809
+Y + A F+ GS LV ++ T VFFS+ + A SV Q++ A +A I
Sbjct: 305 IYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVI 364
Query: 810 FNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVAL 869
F+I+D+ P IDS S G +++ GN+E V+FSYP+R +I+I K L L + S +TVAL
Sbjct: 365 FDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVAL 424
Query: 870 VGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIR 929
VG SG GKST + LL+R YDP G + +DG DI+ F + LR+ +G+V QEP+LF+ +I
Sbjct: 425 VGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIA 484
Query: 930 ANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARA 989
NI YG+ T DEI A ANA++FI LP +DT VG+RG QLSGGQKQRIAIARA
Sbjct: 485 ENIRYGR-GNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARA 543
Query: 990 MLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNG 1049
+++NPKILLLDEATSALD ESE VQ ALD+ RTT+++AHRL+T+R AD IA ++G
Sbjct: 544 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 603
Query: 1050 MVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
++ E+G H EL+ G+Y LV + ++ S
Sbjct: 604 VIVEQGSHSELIKK-EGIYFRLVNMQTSGS 632
Score = 45.8 bits (107), Expect = 6e-04
Identities = 37/150 (24%), Positives = 59/150 (38%), Gaps = 20/150 (13%)
Query: 614 VDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELP---VILLGTIAAMVNGVVFPIFGF 670
+D + E G + N + K N I L + +LLGT A+ +G P+
Sbjct: 14 LDGDFELGSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMI 73
Query: 671 LFSAVISMFY-----------------KPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNY 713
+F + F P +E ++ Y GLG L+ ++
Sbjct: 74 VFGEMTDKFVDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVS 133
Query: 714 FFGTAGGKLIERIRSLTFAKIVHQEIRWFD 743
F+ A G+ I +IR F I+ QE+ WFD
Sbjct: 134 FWTLAAGRQIRKIRQKFFHAILRQEMGWFD 163
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 459 bits (1182), Expect = e-128
Identities = 284/839 (33%), Positives = 451/839 (52%), Gaps = 99/839 (11%)
Query: 3 DNTEVHENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMT 61
++ + + N S Q K + + V F++LF F+ D+ LM +G++ A +G A P +
Sbjct: 21 ESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVL 80
Query: 62 LLLGKVINAF--------------------------GSSNQS----------EVLNQVSK 85
L+ G + + F S NQ+ + +++ K
Sbjct: 81 LIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIK 140
Query: 86 VSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVI 145
+ + +A+ IT ++Q+ W++ RQ ++R Y + I++ +I +FD + GE+
Sbjct: 141 FASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS-VGELN 199
Query: 146 SRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFM 205
+R S D I +A+ +++ F+Q ++ GF++ F +GW+L LV+++ P I + A +
Sbjct: 200 TRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATI 259
Query: 206 AMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQS 265
+ ++K AYA+AG VA++ + SMRTVA+F GEK+ +E+Y + A +++
Sbjct: 260 GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKG 319
Query: 266 IASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPS 324
I G G + +IF Y +A WYGS LV+ +G Y GT++ + ++++ G+++LG SP
Sbjct: 320 IVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPC 379
Query: 325 LHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFA 384
L AFA G+AAA +FETI RKP ID G L+ IKG+IE +V F YP+RP+V+I
Sbjct: 380 LEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILN 439
Query: 385 GFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIG 444
++ + G TALVG SG+GKST + L++RFYDP G V +DG ++++L ++W+R+QIG
Sbjct: 440 DLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIG 499
Query: 445 LVSQE------------------------------------------------RQNGTQL 456
+V QE + G Q+
Sbjct: 500 IVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQM 559
Query: 457 SGGQKQRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTT 516
SGGQKQR+AIARA+++NPKILLLD ATSALD ESE +VQE L KI T I VAHRL+T
Sbjct: 560 SGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLST 619
Query: 517 IIHADTIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNL 576
+ ADTI + G VERGTH EL ++ G Y L+ LQ +A + D D++
Sbjct: 620 VRAADTIIGFEHGTAVERGTHEEL-LERKGVYFTLVTLQSQGNQALNEEDIK-DATEDDM 677
Query: 577 NIDIHMAGS---STQRISFVRSISQTSSMSHRHSQLSGEIVD--ANIEQGQVDNNEKPKM 631
GS S + RS SQ S + H +VD + E+ + D + +
Sbjct: 678 LARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIPVQE 734
Query: 632 SMKNS-IWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKP-PEQQRKE 689
++ + + R+ K + PE P +L+G++ A VNG V P++ FLFS ++ F P E+QR +
Sbjct: 735 EVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQ 794
Query: 690 SRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
L++V +G V+L L+ Y F +G L +R+R F ++ Q+I WFDD +S
Sbjct: 795 INGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNS 853
Score = 332 bits (850), Expect = 4e-90
Identities = 201/603 (33%), Positives = 320/603 (52%), Gaps = 53/603 (8%)
Query: 1 MADNTEVHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLM 60
+ D+ +E V + + P ++ F+ + M++G++ A NG +PL
Sbjct: 714 VVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAP-EWPYMLVGSVGAAVNGTVTPLY 772
Query: 61 TLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIR 120
L +++ F ++ E +Q++ V LLFV + S T FLQ + +GE + R+R
Sbjct: 773 AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832
Query: 121 SLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVI 179
+ +L QDIA+FD N+ G + +R++ D +Q A G ++G + + +I
Sbjct: 833 KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892
Query: 180 AFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVAS 239
AF W+L+LV+L P + ++GA ++ A R + A G + N+ + ++RTVA
Sbjct: 893 AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAG 952
Query: 240 FTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGY 299
E++ IE ++++ + +Q++ G I+F + + YG L+ +G
Sbjct: 953 IGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGL 1012
Query: 300 NGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLVLE 359
+ V V+ A+V + +LG+ ++A K +A + F+ + R+P I Y+T+G +
Sbjct: 1013 HFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD 1072
Query: 360 DIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDP 419
+ +G I+ D F YP+RPD ++ G S+ + G T A VG SG GKST I LLERFYDP
Sbjct: 1073 NFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDP 1132
Query: 420 NAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------------------------ 449
+ G+V+IDG + K + ++++R IG+VSQE
Sbjct: 1133 DQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAA 1192
Query: 450 --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
G+QLS G+KQRIAIARAI+++PKILLLDEATSALD E
Sbjct: 1193 KQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTE 1252
Query: 490 SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
SE VQ AL+K RT IV+AHRL+TI +AD IAV+ QG ++E+GTH EL M GAY
Sbjct: 1253 SEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL-MAQKGAYY 1311
Query: 550 QLI 552
+L+
Sbjct: 1312 KLV 1314
Score = 291 bits (744), Expect = 8e-78
Identities = 157/331 (47%), Positives = 214/331 (64%), Gaps = 9/331 (2%)
Query: 750 LYCTNAFIFYIGSILV----HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
++ A F+ GS LV + T V+IF S+ + A+++ +S +
Sbjct: 333 IFLCYAVAFWYGSTLVLDEGEYTPGTLVQIF---LSVIVGALNLGNASPCLEAFATGRAA 389
Query: 806 AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
A SIF +D KP ID S DG + + G IE +V F YP+RP+++I DL + I +
Sbjct: 390 ATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGE 449
Query: 866 TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
ALVG SG+GKST + L++RFYDP G V +DG DI++ I WLR Q+G+V QEP+LF+
Sbjct: 450 MTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFS 509
Query: 926 ESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIA 985
+I NI YG+ED AT ++I+ AA ANA+NFI LP +DT VGE G Q+SGGQKQR+A
Sbjct: 510 TTIAENIRYGRED-ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVA 568
Query: 986 IARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAV 1045
IARA+++NPKILLLD ATSALD ESE +VQE L ++ T + VAHRL+T+R ADTI
Sbjct: 569 IARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIG 628
Query: 1046 IKNGMVAEKGRHDELMNNTHGVYASLVALHS 1076
++G E+G H+EL+ GVY +LV L S
Sbjct: 629 FEHGTAVERGTHEELLER-KGVYFTLVTLQS 658
Score = 279 bits (714), Expect = 3e-74
Identities = 153/337 (45%), Positives = 214/337 (63%), Gaps = 6/337 (1%)
Query: 746 AHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
A ++ N+ + G L+ + F +FRV ++ ++A ++ ++ + P KA S
Sbjct: 988 AQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKIS 1047
Query: 806 AASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAK 865
AA F +LD +P I + G + G I+ F+YP+RPD Q+ L++SI +
Sbjct: 1048 AARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQ 1107
Query: 866 TVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFN 925
T+A VG SG GKST I LLERFYDP+ G+V++DG D K + +LR +G+V QEP+LF
Sbjct: 1108 TLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFA 1167
Query: 926 ESIRANIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQ 982
SI NI YG D E + +IAAA A H+F+ SLP+ Y+T+VG +G+QLS G+KQ
Sbjct: 1168 CSIMDNIKYG--DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQ 1225
Query: 983 RIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADT 1042
RIAIARA++++PKILLLDEATSALD ESE+ VQ ALD+ RT +++AHRL+TI+ AD
Sbjct: 1226 RIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADI 1285
Query: 1043 IAVIKNGMVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
IAV+ G+V EKG H+ELM G Y LV S S
Sbjct: 1286 IAVMAQGVVIEKGTHEELMAQ-KGAYYKLVTTGSPIS 1321
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 447 bits (1151), Expect = e-125
Identities = 287/839 (34%), Positives = 430/839 (51%), Gaps = 117/839 (13%)
Query: 8 HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
H N S Q K V F++LF F+ D LM +G++ A+ +G A P M ++ G
Sbjct: 26 HNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGI 85
Query: 67 VINAF--------------------------GSSNQS----------EVLNQVSKVSLLF 90
+ + F S NQ+ ++ ++V K S ++
Sbjct: 86 LTDIFVEYDIERQELSIPGKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIY 145
Query: 91 VYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
+ + I + Q+ W++TG RQ ++R Y + I++ +I +FD T+ GE+ SR S
Sbjct: 146 AGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDC-TSVGELNSRFSD 204
Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
D I EA+ +++ FLQ ST G ++ F +GW+L LV+LA P I + A + + +A
Sbjct: 205 DINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVA 264
Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
K AYA+AG++A++ + S+RTVA+F GE K +E+Y + A + + + G
Sbjct: 265 KFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGF 324
Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
G + +IF Y LA WYGS+LV+ +G Y GT++ + + ++ +M++G S L F+
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFS 384
Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
G +AA +F+TI R+P +D G L+ IKG+IE +V F YP+RP+V+I S+
Sbjct: 385 TGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMV 444
Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
+ G TTA VG SG+GKST + L++RFYDP G V +DG ++++L +RW+R+QIG+V QE
Sbjct: 445 IKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQE 504
Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
+ G Q+SGGQK
Sbjct: 505 PVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQK 564
Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
QR+AIARA+++ PKILLLD ATSALD ESE VQ AL KI T I VAHRL+T+ AD
Sbjct: 565 QRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSAD 624
Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQ------------EGEKEAEG---SRS 566
I + G VERGTH EL ++ G Y L+ LQ +G+ EG R+
Sbjct: 625 VIIGFEHGTAVERGTHEEL-LERKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERT 683
Query: 567 SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNN 626
+ D+L I RS SQ S +SH G+ + + + DN+
Sbjct: 684 FSRGSYQDSLRASIRQ-----------RSKSQLSHLSHEPPLAIGD--HKSSYEDRKDND 730
Query: 627 EKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMF-YKPPEQ 685
+ + R+ K N E P IL+G + A +NG V PI+ LFS ++ F EQ
Sbjct: 731 VLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQ 790
Query: 686 QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDD 744
QR E L +V LG V+L L+ Y F +G L +R+R F ++ Q+I WFDD
Sbjct: 791 QRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDD 849
Score = 317 bits (811), Expect = 1e-85
Identities = 189/561 (33%), Positives = 304/561 (53%), Gaps = 52/561 (9%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
+++G + A NG +P+ +LL +++ F ++ + +++ + L FV L S T F
Sbjct: 755 ILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQF 814
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDT-ETNTGEVISRMSGDTILIQEAMGE 161
LQ + +GE + R+R K +L+QDI +FD + N G + +R++ D +Q A G
Sbjct: 815 LQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGS 874
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
+VG + + F +IAF+ W+L+LV+ P + ++GA ++ A + +
Sbjct: 875 QVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILE 934
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
+AG + N+ + ++RTVA E + I+ + +++ +Y ++++ G+ I F
Sbjct: 935 KAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFL 994
Query: 282 SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
+ A YG L++ + N V VV ++ + ++G+T ++A K +A + F+
Sbjct: 995 ANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQL 1054
Query: 342 IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
+ RKP ID Y +G ++ +G I+ D F YP+RPD+++ G S+ V G T A VG
Sbjct: 1055 LDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGS 1114
Query: 402 SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
SG GKST I LLERFYDP+ G V+IDG + K + ++++R IG+VSQE
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNI 1174
Query: 450 ---------------------------------RQNGTQLSGGQ-----KQRIAIARAIL 471
+ + G Q KQRIAIARAI+
Sbjct: 1175 KYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIV 1234
Query: 472 KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
++PKILLLDEATSALD ESE VQ AL+K RT IV+AHRL+TI ++D IAV+ QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVV 1294
Query: 532 VERGTHSELTMDPHGAYSQLI 552
+E+GTH +L MD GAY +L+
Sbjct: 1295 IEKGTHKKL-MDQKGAYYKLV 1314
Score = 283 bits (723), Expect = 2e-75
Identities = 154/325 (47%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 751 YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
+ N+ + G L+ + F +FRV S+ M+A +V ++ + P KA SAA F
Sbjct: 993 FLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFF 1052
Query: 811 NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
+LD KP ID S G + G I+ F+YP+RPDIQ+ L++S+ +T+A V
Sbjct: 1053 QLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFV 1112
Query: 871 GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
G SG GKST I LLERFYDP+ G V++DG D K + +LR +G+V QEP+LF+ SI
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMD 1172
Query: 931 NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
NI YG D E + IAAA A H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIA 1230
Query: 988 RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
RA++++PKILLLDEATSALD ESE+ VQ ALD+ RT +++AHRL+TI+ +D IAV+
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMS 1290
Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
G+V EKG H +LM+ G Y LV
Sbjct: 1291 QGVVIEKGTHKKLMDQ-KGAYYKLV 1314
Score = 280 bits (717), Expect = 1e-74
Identities = 149/323 (46%), Positives = 212/323 (65%), Gaps = 3/323 (0%)
Query: 755 AFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL 813
A F+ GS LV + T + ++F + + AM++ +S+ + +A+SIF +
Sbjct: 338 ALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTI 397
Query: 814 DSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGES 873
D +P +D S DG + + G IE +V F YP+RP+++I +L++ I +T A VG S
Sbjct: 398 DRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSS 457
Query: 874 GSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIA 933
G+GKST + L++RFYDP G V LDG DI++ I WLR Q+G+V QEP+LF+ +I NI
Sbjct: 458 GAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIR 517
Query: 934 YGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
G+E+ AT ++I+ AA ANA+NFI +LP +DT VGE G Q+SGGQKQR+AIARA+++
Sbjct: 518 LGREE-ATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRK 576
Query: 994 PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
PKILLLD ATSALD ESE VQ AL+++ T + VAHRL+T+R AD I ++G E
Sbjct: 577 PKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVE 636
Query: 1054 KGRHDELMNNTHGVYASLVALHS 1076
+G H+EL+ GVY LV L S
Sbjct: 637 RGTHEELLER-KGVYFMLVTLQS 658
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 444 bits (1141), Expect = e-124
Identities = 283/839 (33%), Positives = 433/839 (50%), Gaps = 117/839 (13%)
Query: 8 HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
H N S Q K I V F++LF F+ D+ LM++G + A+ +G A P + ++ G
Sbjct: 26 HNNDKKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGI 85
Query: 67 VINAF--------------------------GSSNQS----------EVLNQVSKVSLLF 90
+ + F S +Q+ ++ +++ K S ++
Sbjct: 86 MTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIY 145
Query: 91 VYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
+ + I + Q+ W++TG RQ R+R +Y + I++ +I +FD T+ GE+ SR +
Sbjct: 146 AGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDC-TSVGELNSRFAD 204
Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
D I +A+ +++ FLQ ST G ++ F +GW+L LV+LA P I + A + + +A
Sbjct: 205 DIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIA 264
Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
K AYA+AG++A++ + S+RTVA+F GE K +E+Y + A + + + G
Sbjct: 265 KFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGF 324
Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVI-AKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
G + +IF Y LA WYGS LV+ + Y GT++ + + ++ +M++G S L F+
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFS 384
Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
G +AA +F+TI R+P ID G L+ IKG+IE +V F YP+RPDV+I S+
Sbjct: 385 TGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMV 444
Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
+ G TTALVG SG+GKST + L++RFYDP G V +DG ++++L +RW+R+QIG+V QE
Sbjct: 445 IKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQE 504
Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
+ G Q+SGGQK
Sbjct: 505 PVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQK 564
Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
QR+AIARA+++NPKILLLD ATSALD ESE VQEAL KI T I VAHRL+T+ AD
Sbjct: 565 QRVAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAAD 624
Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQE------------GEKEAEG---SRS 566
I + G VERGTH EL ++ G Y L+ LQ G+ EG R+
Sbjct: 625 VIIGFEHGVAVERGTHEEL-LERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERT 683
Query: 567 SEVDKFGDNLNIDIHMAGSSTQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNN 626
+ D+L I S ++S + + H+ S + D +E+ +
Sbjct: 684 FSRGSYRDSLRASIRQRSKS--QLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVE---- 737
Query: 627 EKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMF-YKPPEQ 685
+ R+ K N PE IL+G+++A +NG V PI+ LFS ++ F EQ
Sbjct: 738 -------PAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQ 790
Query: 686 QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDD 744
QR E L +V LG V++ L+ Y F +G L +R+R F ++ Q+I WFDD
Sbjct: 791 QRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDD 849
Score = 313 bits (801), Expect = 2e-84
Identities = 188/561 (33%), Positives = 301/561 (53%), Gaps = 52/561 (9%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
+++G++SA NG +P+ +LL +++ F ++ + +++ + L FV L S T F
Sbjct: 755 ILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQF 814
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDT-ETNTGEVISRMSGDTILIQEAMGE 161
LQ + +GE + R+R K +L QDI +FD N G + +R++ D +Q A G
Sbjct: 815 LQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGS 874
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
+VG + + +IAF W+L+L++ P + ++GA ++ A + + A
Sbjct: 875 QVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALE 934
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
+AG + ++ + ++RTVA E + I+ + +++ +Y V+++ G+ I F
Sbjct: 935 KAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFL 994
Query: 282 SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
+ A YG L+ +G V VV ++ + ++G+T ++A K +A + F+
Sbjct: 995 ANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQL 1054
Query: 342 IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
+ RKP I+ Y +G ++ +G I+ D F YP+RPD+++ G S+ V G T A VG
Sbjct: 1055 LDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGS 1114
Query: 402 SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
SG GKST I LLERFYDP+ G V+IDG + K + ++++R IG+VSQE
Sbjct: 1115 SGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNI 1174
Query: 450 ---------------------------------RQNGTQLSGGQ-----KQRIAIARAIL 471
+ + G Q KQRIAIARAI+
Sbjct: 1175 KYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIV 1234
Query: 472 KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
++PKILLLDEATSALD ESE VQ AL+K RT IV+AHRL+TI ++D IAVV QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVV 1294
Query: 532 VERGTHSELTMDPHGAYSQLI 552
+E+GTH +L M GAY +L+
Sbjct: 1295 IEKGTHEKL-MAQKGAYYKLV 1314
Score = 293 bits (750), Expect = 2e-78
Identities = 154/323 (47%), Positives = 216/323 (66%), Gaps = 3/323 (0%)
Query: 755 AFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL 813
A F+ GS LV + T + ++F + + AM++ +S+ + +A +IF +
Sbjct: 338 ALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTI 397
Query: 814 DSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGES 873
D +P ID S DG + + G IE +V F YP+RPD++I +L++ I +T ALVG S
Sbjct: 398 DRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSS 457
Query: 874 GSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIA 933
G+GKST + L++RFYDP G V LDG DI++ I WLR Q+G+V QEP+LF+ +I NI
Sbjct: 458 GAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIR 517
Query: 934 YGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
+G+ED AT ++I+ AA ANA+NFI +LP +DT VGE G Q+SGGQKQR+AIARA+++N
Sbjct: 518 FGRED-ATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRN 576
Query: 994 PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
PKILLLD ATSALD ESE VQEAL+++ T + VAHRL+T+R AD I ++G+ E
Sbjct: 577 PKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVE 636
Query: 1054 KGRHDELMNNTHGVYASLVALHS 1076
+G H+EL+ GVY LV L S
Sbjct: 637 RGTHEELLER-KGVYFMLVTLQS 658
Score = 281 bits (718), Expect = 9e-75
Identities = 153/325 (47%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 751 YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
+ N+ + G L+ + F +FRV S+ ++A +V ++ + P KA SAA F
Sbjct: 993 FLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFF 1052
Query: 811 NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
+LD KP I+ S G + G I+ F+YP+RPDIQ+ L++S+ +T+A V
Sbjct: 1053 QLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFV 1112
Query: 871 GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
G SG GKST I LLERFYDP+ G V++DG D K I +LR +G+V QEP+LF+ SI
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMD 1172
Query: 931 NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
NI YG D E + IAAA A H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIA 1230
Query: 988 RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
RA++++PKILLLDEATSALD ESE+ VQ ALD+ RT +++AHRL+TI+ +D IAV+
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVS 1290
Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
G+V EKG H++LM G Y LV
Sbjct: 1291 QGVVIEKGTHEKLMAQ-KGAYYKLV 1314
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 432 bits (1110), Expect = e-120
Identities = 278/832 (33%), Positives = 433/832 (51%), Gaps = 95/832 (11%)
Query: 8 HENSSSSTQQHVNKANQI-VPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
+ N S Q K++ + + F++LF F+ D+ LM +G++ A +G A P + L+ G
Sbjct: 26 YNNEKKSRLQDKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGT 85
Query: 67 VINAF-------------------------GSSNQSEVLN---------QVSKVSLLFVY 92
+ + F SS V N + + Y
Sbjct: 86 MTDVFIDYDTELQELKIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDIESEMIRFAGYY 145
Query: 93 LAIGSGI--TSFLQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSG 150
IG + T ++Q+ W + Q ++R Y + I++ I + D + G++ + S
Sbjct: 146 AGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNS-VGKLNTPFSV 204
Query: 151 DTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMA 210
D I ++ +++ F+Q ++ GF++ F + W+L LV+++ P I + A + + ++
Sbjct: 205 DFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVS 264
Query: 211 KMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGI 270
K AYA+AG+VA++ + SMRTVA+F GEKK +E+Y + A +++ I G
Sbjct: 265 KFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGF 324
Query: 271 GMGTLLLIIFCSYGLAMWYGSKLVIAKG-YNGGTVMTVVIALVTGSMSLGQTSPSLHAFA 329
G + +IF Y LA WYGSKLV+ +G Y+ G ++ + ++++ G+++LG SP L AFA
Sbjct: 325 FTGYMWCLIFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFA 384
Query: 330 AGKAAAYKMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLF 389
AG+AAA +FETI RKP ID G LE IKG+IE +V F YP+RP+V+I S+
Sbjct: 385 AGRAAASSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMV 444
Query: 390 VPSGTTTALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE 449
+ G TALVG SG+GKST + L+ RFY P G V ++ ++++ ++W+R QIG+V QE
Sbjct: 445 IKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQE 504
Query: 450 ------------------------------------------------RQNGTQLSGGQK 461
+ G Q+SGGQK
Sbjct: 505 PVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQK 564
Query: 462 QRIAIARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHAD 521
QR+AIARA+++NPKILLLD ATSALD ESE +VQEAL K T + VAHR TI AD
Sbjct: 565 QRVAIARALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTAD 624
Query: 522 TIAVVQQGKIVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIH 581
I + G VERGT EL ++ G Y L+ LQ + + +E D D++
Sbjct: 625 VIIGCEHGAAVERGTEEEL-LERKGVYFALVTLQSQRNQGD-QEENEKDATEDDIPEKTF 682
Query: 582 MAGS---STQRISFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMK-NSI 637
G+ S + RS SQ S ++H ++ E + E+ + D + + ++ S+
Sbjct: 683 SRGNYQDSLRASLRQRSKSQLSYLAH-EPPMAVEDHKSTHEEDRKDKDLPAQEDIEPASV 741
Query: 638 WRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKP-PEQQRKESRFWSLV 696
R+ KLN PE P +LLG++ A VNG V P++ FLFS ++ F P E+QR + L+
Sbjct: 742 RRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLL 801
Query: 697 YVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
+V LG V+ L+ Y F +G L +R+R F ++ Q+I WFDD +S
Sbjct: 802 FVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNS 853
Score = 328 bits (842), Expect = 4e-89
Identities = 192/561 (34%), Positives = 309/561 (54%), Gaps = 52/561 (9%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
M++G++ A NG +PL L +++ F ++ E +Q++ + LLFV L S T F
Sbjct: 755 MLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQF 814
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
LQ + +GE + R+R + +L QDI +FD N+ G + +R++ D +Q A G
Sbjct: 815 LQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGS 874
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
++G + + +IAF+ W+L L ++ P + ++GA ++ A R + A
Sbjct: 875 QIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALE 934
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
+AG + ++ + ++RTVA E+K IE + ++++ Y ++++ G+ G I F
Sbjct: 935 KAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFI 994
Query: 282 SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
+ + YG L+ +G + V V+ A+V + +LG+ S ++A K +A + F+
Sbjct: 995 ANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQL 1054
Query: 342 IKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQ 401
+ R+P I+ Y ++G ++ +G I+ D F YP+RPD+++ G S+ + T A VG
Sbjct: 1055 LDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGS 1114
Query: 402 SGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------------ 449
SG GKST I LLERFYDP+ G+V+IDG + + + ++++R IG+VSQE
Sbjct: 1115 SGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNI 1174
Query: 450 --------------------------------------RQNGTQLSGGQKQRIAIARAIL 471
G+QLS G+KQRIAIARAI+
Sbjct: 1175 KYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
Query: 472 KNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKI 531
++PKILLLDEATSALD ESE VQ AL+K RT IV+AHRL+TI ++D IAV+ QG +
Sbjct: 1235 RDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGMV 1294
Query: 532 VERGTHSELTMDPHGAYSQLI 552
+E+GTH EL M GAY +L+
Sbjct: 1295 IEKGTHEEL-MVQKGAYYKLV 1314
Score = 284 bits (727), Expect = 8e-76
Identities = 155/332 (46%), Positives = 217/332 (64%), Gaps = 6/332 (1%)
Query: 751 YCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
+ N+ + G L+ + F +FRV ++ ++A ++ ++S+ P KA SAA F
Sbjct: 993 FIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFF 1052
Query: 811 NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
+LD +P I+ S+ G + G I+ F+YP+RPDIQ+ L++S+ +T+A V
Sbjct: 1053 QLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFV 1112
Query: 871 GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
G SG GKST I LLERFYDP+ G+V++DG D + I +LR +G+V QEP+LF SI+
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKD 1172
Query: 931 NIAYGKEDGATE---DEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
NI YG D E + IIAAA A H+F+ SLP+ Y+T+VG +G+QLS G+KQRIAIA
Sbjct: 1173 NIKYG--DNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIA 1230
Query: 988 RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
RA++++PKILLLDEATSALD ESE+ VQ ALD+ RT +++AHRL+TI+ +D IAV+
Sbjct: 1231 RAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMS 1290
Query: 1048 NGMVAEKGRHDELMNNTHGVYASLVALHSTAS 1079
GMV EKG H+ELM G Y LV S S
Sbjct: 1291 QGMVIEKGTHEELMVQ-KGAYYKLVTTGSPIS 1321
Score = 273 bits (697), Expect = 2e-72
Identities = 174/446 (39%), Positives = 247/446 (55%), Gaps = 29/446 (6%)
Query: 656 IAAMVNGVVFPIFGFLFSAVISMFYKPPEQQRKESRFWSL--VYVGLGLVTLVVFPLKNY 713
+A + G+ PIFGFL S ++K S L +GL + + LK Y
Sbjct: 217 LAIFIQGMTSPIFGFLVG--FSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAY 274
Query: 714 F-FGTAGGKLIERIRSLTFAKIVHQEI-----------RW----------FDDPAHSSLY 751
G+ ++I +R++ +E+ RW F ++
Sbjct: 275 AKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIF 334
Query: 752 CTNAFIFYIGSILV-HHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIF 810
A F+ GS LV + + + ++F S+ + A+++ +S +A+SIF
Sbjct: 335 FCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIF 394
Query: 811 NILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALV 870
+D KP ID S DG E + G IE +V F YP+RP+++I +L++ I + ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALV 454
Query: 871 GESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRA 930
G SG+GKST + L+ RFY P G V ++ DI++ I WLR Q+G+V QEP+LF +I
Sbjct: 455 GPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAE 514
Query: 931 NIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAM 990
I YG+ED AT +++I AA ANA+NFI LP +DT VGE G Q+SGGQKQR+AIARA+
Sbjct: 515 KIRYGRED-ATMEDLIQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARAL 573
Query: 991 LKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGM 1050
++NPKILLLD ATSALD ESE +VQEAL + T V VAHR TIR AD I ++G
Sbjct: 574 IRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSVAHRPATIRTADVIIGCEHGA 633
Query: 1051 VAEKGRHDELMNNTHGVYASLVALHS 1076
E+G +EL+ GVY +LV L S
Sbjct: 634 AVERGTEEELLER-KGVYFALVTLQS 658
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein
A)
Length = 1321
Score = 407 bits (1046), Expect = e-113
Identities = 260/811 (32%), Positives = 420/811 (51%), Gaps = 89/811 (10%)
Query: 16 QQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGKVINAF---- 71
++ VNK + +P +L+ + L+ L+ IGT+ A+ G PLM++L GKV AF
Sbjct: 54 EEVVNKVS--IP--QLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQ 109
Query: 72 ------GSS--------NQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSA 117
GS+ +++ + V V + + +G + V+C++ E+ +
Sbjct: 110 IVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNN 169
Query: 118 RIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGF 177
R+R ++K+IL+Q+I++FDT ++G + +++ + ++E G+K+G Q S F GF
Sbjct: 170 RLRREFVKSILRQEISWFDTN-HSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGF 228
Query: 178 VIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTV 237
++AF W+L LV+LA P + G +A M+ AIR + YA+AG V +T+ S+RTV
Sbjct: 229 IVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTV 288
Query: 238 ASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAK 297
S G + +E+Y++ ++ A A V + + GI G + F S+ LA + G V
Sbjct: 289 VSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDG 348
Query: 298 GYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGLV 357
N G ++T +++ GSM+LG P L + AA ++E + RKP ID+ +G
Sbjct: 349 SLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRK 408
Query: 358 LEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFY 417
IKGDI + +VHF YP+RPDV I G +L V +G T ALVG SG GKST+ISLL R+Y
Sbjct: 409 DMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYY 468
Query: 418 DPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------------------------- 449
D G++ IDGV+++++ L ++R+ + +VSQE
Sbjct: 469 DVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAAC 528
Query: 450 --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
GTQLSGGQKQRIAIARA+++NPKILLLDEATSALDAE
Sbjct: 529 KMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAE 588
Query: 490 SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
SE IVQ+AL+K RTTI++AHRL+TI +AD I + G++VE G H L M G Y
Sbjct: 589 SEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRAL-MAQQGLYY 647
Query: 550 QLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQ-----------RISFVRSISQ 598
L+ Q + + + + G S Q R S + SI+
Sbjct: 648 DLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITN 707
Query: 599 TSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAA 658
+ + ++ G+ + ++Q +NN + K +++ + +P + +G A
Sbjct: 708 GPVIDEKEERI-GKDALSRLKQELEENN-----AQKTNLFEILYHARPHALSLFIGMSTA 761
Query: 659 MVNGVVFPIFGFLFSAVISMFYKPPEQQRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTA 718
+ G ++P + F++ +++F P + FW+L+++ L + L +F G A
Sbjct: 762 TIGGFIYPTYSVFFTSFMNVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIA 821
Query: 719 GGKLIERIRSLTFAKIVHQEIRWFDDPAHSS 749
L +R+ F ++ Q I +FD P ++S
Sbjct: 822 SESLTRDLRNKLFRNVLSQHIGFFDSPQNAS 852
Score = 305 bits (782), Expect = 3e-82
Identities = 163/325 (50%), Positives = 222/325 (68%), Gaps = 2/325 (0%)
Query: 748 SSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAA 807
+S + + A FYIG VH F ++ F S+ M +M++ + A +A+
Sbjct: 328 ASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAAS 387
Query: 808 SIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTV 867
I+ +LD KP IDSSS G + G+I +++V+F+YP+RPD+ I + + L + + +TV
Sbjct: 388 GIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTV 447
Query: 868 ALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNES 927
ALVG SG GKST+ISLL R+YD G++ +DGVD++ + +LR+ + +V QEP LFN +
Sbjct: 448 ALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCT 507
Query: 928 IRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIA 987
I NI+ GKE G T +E++AA ANA FI +LP+GY+T VG+RGTQLSGGQKQRIAIA
Sbjct: 508 IEENISLGKE-GITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIA 566
Query: 988 RAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIK 1047
RA+++NPKILLLDEATSALDAESE IVQ+ALD+ + RTT+I+AHRL+TIR AD I K
Sbjct: 567 RALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCK 626
Query: 1048 NGMVAEKGRHDELMNNTHGVYASLV 1072
NG V E G H LM G+Y LV
Sbjct: 627 NGQVVEVGDHRALMAQ-QGLYYDLV 650
Score = 290 bits (742), Expect = 1e-77
Identities = 186/571 (32%), Positives = 290/571 (50%), Gaps = 56/571 (9%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
+ IG +A GF P ++ +N F + N ++ L+Q +L+F+ LA GI SF
Sbjct: 754 LFIGMSTATIGGFIYPTYSVFFTSFMNVF-AGNPADFLSQGHFWALMFLVLAAAQGICSF 812
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETN-TGEVISRMSGDTILIQEAMGE 161
L + E + +R+ + +L Q I FFD+ N +G++ +R++ D ++ A+
Sbjct: 813 LMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDF 872
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
+ + + G +AF GW++AL+++A +P + ++ +A
Sbjct: 873 RFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFA 932
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
++G +A + + ++RTV + E E + K+ I + ++++ G+ G +++
Sbjct: 933 DSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYL 992
Query: 282 SYGLAMWYGSKLVIAKG--YNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMF 339
A G L+I V+ V+ A+ + +LG + +A A +F
Sbjct: 993 LNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIF 1052
Query: 340 ETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALV 399
+++ KID+ +G + + G + ++V F YP RP++EI G S V G T ALV
Sbjct: 1053 GMLRKISKIDSLSLAG-EKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALV 1111
Query: 400 GQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE---------- 449
G SG GKSTV++LLERFYD GE+ IDG +K L R QI +VSQE
Sbjct: 1112 GPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAE 1171
Query: 450 ----------------------------------------RQNGTQLSGGQKQRIAIARA 469
GTQLSGGQKQRIAIARA
Sbjct: 1172 NIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARA 1231
Query: 470 ILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQG 529
+++NPKILLLDEATSALD ESE +VQEAL++ RT IV+AHRL T+++AD IAVV G
Sbjct: 1232 LVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNG 1291
Query: 530 KIVERGTHSELTMDPHGAYSQLIRLQEGEKE 560
I+E+GTH++L M GAY +L + Q EK+
Sbjct: 1292 TIIEKGTHTQL-MSEKGAYYKLTQKQMTEKK 1321
Score = 286 bits (731), Expect = 3e-76
Identities = 153/326 (46%), Positives = 214/326 (64%), Gaps = 4/326 (1%)
Query: 746 AHSSLYCTNAFIFYIGSILVHHRKATF--VEIFRVFFSLTMTAMSVSQSSTLFPDTNKAI 803
A S LY N + +G L+ T + + RV +++T++ ++ +++ FP+ KA
Sbjct: 986 ASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKAT 1045
Query: 804 DSAASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPS 863
+ IF +L IDS S G ++ + G + ++V F+YP RP+I+I K L+ S+
Sbjct: 1046 FAGGIIFGMLRKISKIDSLSLAG-EKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEP 1104
Query: 864 AKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPIL 923
+T+ALVG SG GKSTV++LLERFYD G + +DG +IKT R Q+ +V QEP L
Sbjct: 1105 GQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTL 1164
Query: 924 FNESIRANIAYGKEDGA-TEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQ 982
F+ SI NI YG + + T ++ AA AN HNFI+ LP+G++T VG+RGTQLSGGQKQ
Sbjct: 1165 FDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQ 1224
Query: 983 RIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADT 1042
RIAIARA+++NPKILLLDEATSALD ESE++VQEALDR RT +++AHRL T+ AD
Sbjct: 1225 RIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADC 1284
Query: 1043 IAVIKNGMVAEKGRHDELMNNTHGVY 1068
IAV+ NG + EKG H +LM+ Y
Sbjct: 1285 IAVVSNGTIIEKGTHTQLMSEKGAYY 1310
Score = 33.5 bits (75), Expect = 3.2
Identities = 38/168 (22%), Positives = 67/168 (39%), Gaps = 26/168 (15%)
Query: 611 GEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKP-ELPVILLGTIAAMVNGVVFPIFG 669
G+ +D+N E ++ + K ++ K SI +L + E ++ +GT+ A++ G P+
Sbjct: 37 GDNIDSNGEI-KITRDAKEEVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMS 95
Query: 670 FLFSAVISMF-------------YKPPEQQRKESRF--------WSLVYVGLGLVTLVVF 708
L V F + P Q ++ F WS + +G+
Sbjct: 96 ILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQI 155
Query: 709 PLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHSSLYCTNAF 756
+ Y + ++ R+R I+ QEI WF D HS T F
Sbjct: 156 TVTCYLY--VAEQMNNRLRREFVKSILRQEISWF-DTNHSGTLATKLF 200
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 382 bits (982), Expect = e-105
Identities = 256/806 (31%), Positives = 403/806 (49%), Gaps = 88/806 (10%)
Query: 28 FYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK-------------------VI 68
++ LF ++ R + L+++ + A A P ++ G+ +
Sbjct: 31 YFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFAL 90
Query: 69 NAFGSSNQ-SEVLNQVSKVSLLFVYLAIGSG-----ITSFLQVSCWMVTGER----QSAR 118
FG Q + + + +++ A G G + FL ++ + R Q R
Sbjct: 91 PMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDR 150
Query: 119 IRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFV 178
IR L+L+ +L+QDIA++DT + + S+M+ D ++E +GEK+ + L TF G V
Sbjct: 151 IRKLFLEAMLRQDIAWYDTSSGSN-FASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIV 209
Query: 179 IAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVA 238
AF+ GW+L LV+L+CVP I+ A + +A + +A + +Y++A NV + +RTV
Sbjct: 210 SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVF 269
Query: 239 SFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKG 298
+F+G++K E++ + A ++ + SG+G LII+ LA+WYG L++ +
Sbjct: 270 AFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329
Query: 299 ------YNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYD 352
Y ++ V+ A++ G+ +LG SP + A A AA +F I R ++D D
Sbjct: 330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
Query: 353 TSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISL 412
G E+ G I + FRYPARPDVEI G ++ V G T A VG SG GKST+I L
Sbjct: 390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQL 449
Query: 413 LERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE----------------------- 449
++RFYDP AG V +DG +L+ L + W+R QIG+V QE
Sbjct: 450 MQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509
Query: 450 -------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATS 484
+ G Q+SGGQKQRIAIARA+++ P++LLLDEATS
Sbjct: 510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATS 569
Query: 485 ALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDP 544
ALD SE VQ ALE TT+VVAHRL+TI +AD I ++ G + E+GTH EL M+
Sbjct: 570 ALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEEL-MER 628
Query: 545 HGAYSQLIRLQEGEKEAEGSRSSEVDK-FGDNLNIDIHMAGSSTQRISFVRSISQTSSMS 603
G Y +L+ + + ++ E + + + N+ + +S S
Sbjct: 629 RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGS 688
Query: 604 HRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGV 663
R S Q + +K +S K S +L KLN PE I++G IA++++G
Sbjct: 689 SRDSGFRASTRRKRRSQRRKKKKDKEVVS-KVSFTQLMKLNSPEWRFIVVGGIASVMHGA 747
Query: 664 VFPIFGFLFSAVISMFYKPPEQ-QRKESRFWSLVYVGLGLVTLVVFPLKNYFFGTAGGKL 722
FP++G F + + R E S+++VG+GL+ + L+ Y F TAG K+
Sbjct: 748 TFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKM 807
Query: 723 IERIRSLTFAKIVHQEIRWFDDPAHS 748
R+R F I+ Q+I +FDD +S
Sbjct: 808 TTRLRKRAFGTIIGQDIAYFDDERNS 833
Score = 287 bits (734), Expect = 1e-76
Identities = 147/297 (49%), Positives = 201/297 (67%), Gaps = 2/297 (0%)
Query: 778 VFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSKPDIDSSSNDGVTQETVVGNIE 837
V F++ M A ++ +S A + ++FNI+D +D G E G+I
Sbjct: 344 VLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIR 403
Query: 838 LQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLL 897
+ + F YP RPD++I K LT+ + +TVA VG SG GKST+I L++RFYDP +G V L
Sbjct: 404 FEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKL 463
Query: 898 DGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGKEDGATEDEIIAAANAANAHNF 957
DG D++T + WLR Q+G+VGQEP+LF +I NI YG+ AT+ +I AA AAN H+F
Sbjct: 464 DGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPS-ATQADIEKAARAANCHDF 522
Query: 958 ISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEA 1017
I+ LP GYDT VGE+G Q+SGGQKQRIAIARA+++ P++LLLDEATSALD SE+ VQ A
Sbjct: 523 ITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582
Query: 1018 LDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEKGRHDELMNNTHGVYASLVAL 1074
L+ S TT++VAHRL+TI AD I +K+G+VAE+G H+ELM G+Y LV++
Sbjct: 583 LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSI 638
Score = 279 bits (713), Expect = 3e-74
Identities = 186/570 (32%), Positives = 286/570 (49%), Gaps = 61/570 (10%)
Query: 43 MIIGTISAMANGFASPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSF 102
+++G I+++ +G PL L G + V +V K+S++FV + + +G+ +
Sbjct: 735 IVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNM 794
Query: 103 LQVSCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGE 161
LQ + G + + R+R TI+ QDIA+FD E N+ G + SR++ D +Q A G
Sbjct: 795 LQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGA 854
Query: 162 KVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYA 221
+VG LQ +T G V+ F+ W+ L+ L +P + ++ + K A + + +
Sbjct: 855 RVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIE 914
Query: 222 EAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFC 281
EA VA + + ++RTV E++ +++Y +I A ++ G+ F
Sbjct: 915 EASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFL 974
Query: 282 SYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFET 341
+YG++M+YG LV + N ++ V AL+ GS LGQ +A ++ +
Sbjct: 975 AYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDL 1034
Query: 342 IKR-----KPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTT 396
KR P Y+T +E +GDI +V F YP R I G +L + TT
Sbjct: 1035 FKRTSTQPNPPQSPYNT----VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTV 1090
Query: 397 ALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE------- 449
ALVG SGSGKST + LL R+YDP +G V + GV L +R ++GLVSQE
Sbjct: 1091 ALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRT 1150
Query: 450 ------------------------------------------RQNGTQLSGG-QKQRIAI 466
R T G QKQRIAI
Sbjct: 1151 IAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTSQLSGGQKQRIAI 1210
Query: 467 ARAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVV 526
ARA+++NPKIL+LDEATSALD ESE +VQ+AL++ RT + +AHRLTT+ +AD I V+
Sbjct: 1211 ARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVL 1270
Query: 527 QQGKIVERGTHSELTMDPHGAYSQLIRLQE 556
++G +VE GTH EL M + Y+ L +Q+
Sbjct: 1271 KRGVVVEHGTHDEL-MALNKIYANLYLMQQ 1299
Score = 271 bits (693), Expect = 7e-72
Identities = 155/325 (47%), Positives = 208/325 (63%), Gaps = 9/325 (2%)
Query: 759 YIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNIL---DS 815
Y G ILV + + +I +V +L + + Q+ P+ N AI SA + ++ +
Sbjct: 981 YYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTST 1040
Query: 816 KPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGS 875
+P+ S + T E G+I ++V F YPTR I + L L+I + TVALVG SGS
Sbjct: 1041 QPNPPQSPYN--TVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGS 1098
Query: 876 GKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYG 935
GKST + LL R+YDP SG V L GV F + LR ++GLV QEP+LF+ +I NIAYG
Sbjct: 1099 GKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
Query: 936 KE--DGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKN 993
D + EII AA +N HNFIS+LP GYDT +G+ +QLSGGQKQRIAIARA+++N
Sbjct: 1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKT-SQLSGGQKQRIAIARALVRN 1217
Query: 994 PKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAE 1053
PKIL+LDEATSALD ESE++VQ+ALD RT + +AHRLTT+R AD I V+K G+V E
Sbjct: 1218 PKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVE 1277
Query: 1054 KGRHDELMNNTHGVYASLVALHSTA 1078
G HDELM + +YA+L + +
Sbjct: 1278 HGTHDELM-ALNKIYANLYLMQQVS 1301
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 369 bits (948), Expect = e-101
Identities = 244/759 (32%), Positives = 384/759 (50%), Gaps = 68/759 (8%)
Query: 50 AMANGFASPLMTLLL---GKVI-NAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQV 105
AM G +S + L L GK + NA N + + +L ++ I+ V
Sbjct: 80 AMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSV 139
Query: 106 SCWMVTGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGK 165
+ + RQ R+R ++++QDI + D + S M D I++ + EKVG
Sbjct: 140 DVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQS-MVDDVEKIRDGISEKVGH 198
Query: 166 FLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGN 225
F+ L F I+F GW+L L + + +P +++ ++A K+ R Q +YA AGN
Sbjct: 199 FVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGN 258
Query: 226 VANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGL 285
+A + + S+RTV SF GEK +++Y + + A A + SG+ L +++ S
Sbjct: 259 LAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAG 318
Query: 286 AMWYGSKLVIA------KGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMF 339
A WYG L+I K Y +M ++ G+ ++ +T+P L +FA + A +F
Sbjct: 319 AFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378
Query: 340 ETIKRKPKIDAYDTSGLVLE-DIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTAL 398
+ I KID T G +L ++GD+E +DV FRYP+RP+V + G ++ + +G T AL
Sbjct: 379 KVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVAL 438
Query: 399 VGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------- 449
VG SG GKST + LL+RFYDP G VL+D ++++ ++W+R I +V QE
Sbjct: 439 VGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIA 498
Query: 450 ---------------------------------------RQNGTQLSGGQKQRIAIARAI 470
+ G+QLSGGQKQRIAIARA+
Sbjct: 499 QNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARAL 558
Query: 471 LKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGK 530
++NPKILLLDEATSALD +SE VQ+AL+ RTTIVV+HRL+ I AD I + GK
Sbjct: 559 IQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGK 618
Query: 531 IVERGTHSELTMDPHGAYSQLIRLQEGEKEAEGSRSSEVDKFGDNLNIDIHMAGSSTQRI 590
++E G+H +L M GAY ++R + E + ++ ++ + T +
Sbjct: 619 VLEEGSHDDL-MALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQK-SLALFEKSFETSPL 676
Query: 591 SFVRSISQTSSMSHRHSQLSGEIVDANIEQGQVDNNEKPKMSMKNSIWRLAKLNKPELPV 650
+F + Q +S+ + I D N + + EKP S R+ +L K E
Sbjct: 677 NFEK--GQKNSVQFEEPIIKALIKDTNAQSAEAP-PEKPNFFRTFS--RILQLAKQEWCY 731
Query: 651 ILLGTIAAMVNGVVFPIFGFLFSA-VISMFYKPPEQQRKESRFWSLVYVGLGLVTLVVFP 709
++LGTI+A+ G ++P F +F ++ K PE + + S +GL +T +V
Sbjct: 732 LILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCF 791
Query: 710 LKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWFDDPAHS 748
L+ Y F AG L R+R++TF +V+QE+ WFDD +S
Sbjct: 792 LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNS 830
Score = 308 bits (789), Expect = 5e-83
Identities = 201/607 (33%), Positives = 317/607 (52%), Gaps = 60/607 (9%)
Query: 7 VHENSSSSTQQHVNKANQIVPFYKLFSFADRLDVTLMIIGTISAMANGFASPLMTLLLGK 66
+ + ++ S + K N F ++ A + + +I+GTISA+A GF P ++ G+
Sbjct: 697 IKDTNAQSAEAPPEKPNFFRTFSRILQLAKQ-EWCYLILGTISAVAVGFLYPAFAVIFGE 755
Query: 67 VINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLYLKT 126
A + + L + + +S + LA +G+ FLQ + G + R+R++
Sbjct: 756 FYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNA 815
Query: 127 ILKQDIAFFDTETNT-GEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIKGW 185
++ Q++ +FD E N+ G + +R+SG+ + IQ A+G + +Q S F +A W
Sbjct: 816 MVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNW 875
Query: 186 RLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGEKK 245
+LAL+ LA P IV + A +M+ +R + EA +A +++ ++RTVA E
Sbjct: 876 KLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREAD 935
Query: 246 AIEKYNSKIKIAYTAMVQQSIASGIGMGTLLLIIFCSYGLAMWYGSKLVIAKGYNGGTVM 305
I +Y +I+ + Q+ G+ T+ F +Y +A+ YG LV ++
Sbjct: 936 VIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDII 995
Query: 306 TVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDA-----YDTSGLVLED 360
V L+ GSM L Q+ AF+A A +++F+ + RKPKI + +T L
Sbjct: 996 KVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNL 1055
Query: 361 IKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERFYDPN 420
+G + R + FRYP RPD +I G L V G T ALVG SG GKST + LL+R+YDP+
Sbjct: 1056 FEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPD 1114
Query: 421 AGEVLIDGVNLK-NLQLRWIREQIGLVSQE------------------------------ 449
G + ID +++ +L L +R ++G+VSQE
Sbjct: 1115 EGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAA 1174
Query: 450 --------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSALDAE 489
GTQLSGGQKQRIAIARA+++NPKILLLDEATSALD +
Sbjct: 1175 KSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQ 1234
Query: 490 SEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPHGAYS 549
SE +VQ+AL+ RT IV+AHRL+T+ +AD I V+Q G++VE+G H +L + G Y+
Sbjct: 1235 SEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQL-ISQGGIYA 1293
Query: 550 QLIRLQE 556
+L + Q+
Sbjct: 1294 KLHKTQK 1300
Score = 287 bits (734), Expect = 1e-76
Identities = 156/328 (47%), Positives = 219/328 (66%), Gaps = 7/328 (2%)
Query: 750 LYCTNAFIFYIGSIL----VHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDS 805
L C AF + + I+ V +++ T + FF + + A ++++++ A
Sbjct: 314 LSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGC 373
Query: 806 AASIFNILDSKPDIDSSSNDG-VTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSA 864
A ++F ++D ID S DG + + G++E Q V F YP+RP++ + + L + I +
Sbjct: 374 ATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAG 433
Query: 865 KTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILF 924
+TVALVG SG GKST + LL+RFYDP G VLLD +DI+ + I WLR + +VGQEP+LF
Sbjct: 434 QTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLF 493
Query: 925 NESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRI 984
+I NI+YGK GAT+ EI AAA A AH FI++LP+ Y + +GERG+QLSGGQKQRI
Sbjct: 494 LGTIAQNISYGKP-GATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRI 552
Query: 985 AIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIA 1044
AIARA+++NPKILLLDEATSALD +SE+ VQ+ALD S RTT++V+HRL+ IRGAD I
Sbjct: 553 AIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIV 612
Query: 1045 VIKNGMVAEKGRHDELMNNTHGVYASLV 1072
I +G V E+G HD+LM G Y ++V
Sbjct: 613 FIHDGKVLEEGSHDDLM-ALEGAYYNMV 639
Score = 283 bits (723), Expect = 2e-75
Identities = 157/347 (45%), Positives = 219/347 (62%), Gaps = 10/347 (2%)
Query: 734 IVHQEIRW---FDDPAHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVS 790
++ Q++RW + +S + A G +LV + F +I +V +L +M ++
Sbjct: 950 LIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLA 1009
Query: 791 QSSTLFPDTNKAIDSAASIFNILDSKPDIDSS----SNDGVTQETVVGNIELQHVNFSYP 846
QS P + A+ + +F ILD KP I S N Q + + + + F YP
Sbjct: 1010 QSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYP 1069
Query: 847 TRPDIQIFKDLTLSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIK-TF 905
TRPD +I L L + +TVALVG SG GKST + LL+R+YDP+ G + +D DI+
Sbjct: 1070 TRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDL 1129
Query: 906 RISWLRQQMGLVGQEPILFNESIRANIAYG-KEDGATEDEIIAAANAANAHNFISSLPDG 964
+ +R ++G+V QEP LF SI NIAYG + EIIAAA +ANAH+FI SLP+G
Sbjct: 1130 TLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNG 1189
Query: 965 YDTSVGERGTQLSGGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLN 1024
YDT +G RGTQLSGGQKQRIAIARA+++NPKILLLDEATSALD +SE++VQ+ALD
Sbjct: 1190 YDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG 1249
Query: 1025 RTTVIVAHRLTTIRGADTIAVIKNGMVAEKGRHDELMNNTHGVYASL 1071
RT +++AHRL+T++ AD I VI+NG V E+G H +L++ G+YA L
Sbjct: 1250 RTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ-GGIYAKL 1295
>AB10_MOUSE (Q9JI39) ATP-binding cassette, sub-family B, member 10,
mitochondrial precursor (ATP-binding cassette
transporter 10) (ABC transporter 10 protein)
(ABC-mitochondrial erythroid protein) (ABC-me protein)
Length = 715
Score = 303 bits (776), Expect = 2e-81
Identities = 196/556 (35%), Positives = 304/556 (54%), Gaps = 78/556 (14%)
Query: 64 LGKVINAF---GSSNQSEVLNQVSKV-SLLFVYLAIGSGITSFLQVSCWMVTGERQSARI 119
LG++I+ S + L ++ V + +F+ A +GI +L S +G+ R+
Sbjct: 157 LGRIIDVIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQS----SGQSIVNRL 212
Query: 120 RSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVI 179
R+ +IL+Q++AFFD +T TGE+I+R+S DT L+ ++ E + L+ G+ G +
Sbjct: 213 RTSLFSSILRQEVAFFD-KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGM 271
Query: 180 AFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVAS 239
F LA +L+ VP I V + K++ Q + AEA +A + +G++RT+ +
Sbjct: 272 MFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRA 331
Query: 240 FTGEKKAIEKYNSKIKIAYTAMVQQSIA-------SGIGMGTLLLIIFCSYGLAMWYGSK 292
F E +EKY ++ ++++A +G+ ++L + GL M
Sbjct: 332 FGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHM 391
Query: 293 LVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYD 352
V G + + ++ +S+G S G A +++E ++R+P++ +
Sbjct: 392 TV-------GELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNE 444
Query: 353 TSGLVLED--IKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVI 410
G+VL++ +G +E R+VHF YPARP+V +F FSL +PSG+ TALVG SGSGKSTV+
Sbjct: 445 --GMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVV 502
Query: 411 SLLERFYDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------------------- 449
SLL R YDPN+G V +DG +++ L W+R +IG VSQE
Sbjct: 503 SLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSS 562
Query: 450 ------------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLL 479
+ G LSGGQKQRIAIARA+LKNPKILLL
Sbjct: 563 VTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLL 622
Query: 480 DEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSE 539
DEATSALDAE+EH+VQEAL++++ RT +++AHRL+TI +A+ +AV+ GKI E GTH E
Sbjct: 623 DEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEE 682
Query: 540 LTMDPHGAYSQLIRLQ 555
L + P+G Y +L+ Q
Sbjct: 683 LLLKPNGLYRKLMNKQ 698
Score = 291 bits (746), Expect = 5e-78
Identities = 151/325 (46%), Positives = 213/325 (65%), Gaps = 2/325 (0%)
Query: 757 IFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSK 816
+ Y G +L+ T E+ +S+ S+ + + K + + ++ +L+ +
Sbjct: 378 VLYKGGLLMGSAHMTVGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQ 437
Query: 817 PDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSG 876
P + + + ++T G +E ++V+F+YP RP++ +F+D +LSIPS ALVG SGSG
Sbjct: 438 PRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSG 497
Query: 877 KSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGK 936
KSTV+SLL R YDPNSG V LDG DI+ WLR ++G V QEP+LF+ S+ NIAYG
Sbjct: 498 KSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGA 557
Query: 937 ED--GATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNP 994
++ T ++ AA ANA FI S P G+DT VGE+G LSGGQKQRIAIARA+LKNP
Sbjct: 558 DNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNP 617
Query: 995 KILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEK 1054
KILLLDEATSALDAE+E +VQEALDR+ RT +I+AHRL+TI+ A+ +AV+ +G + E
Sbjct: 618 KILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEH 677
Query: 1055 GRHDELMNNTHGVYASLVALHSTAS 1079
G H+EL+ +G+Y L+ S S
Sbjct: 678 GTHEELLLKPNGLYRKLMNKQSFLS 702
Score = 41.6 bits (96), Expect = 0.012
Identities = 26/121 (21%), Positives = 54/121 (44%), Gaps = 1/121 (0%)
Query: 624 DNNEKPKMSMKNSIWRLAKLNKPELPVILLGTIAAMVNGVVFPIFGFLFSAVISMFYKPP 683
D+ +P + ++ +W+L L +PE + V+ V+ F +I + Y P
Sbjct: 109 DSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNP 168
Query: 684 EQQRKESRF-WSLVYVGLGLVTLVVFPLKNYFFGTAGGKLIERIRSLTFAKIVHQEIRWF 742
+ +S V + L ++ Y ++G ++ R+R+ F+ I+ QE+ +F
Sbjct: 169 SEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFF 228
Query: 743 D 743
D
Sbjct: 229 D 229
>AB10_HUMAN (Q9NRK6) ATP-binding cassette, sub-family B, member 10,
mitochondrial precursor (ATP-binding cassette
transporter 10) (ABC transporter 10 protein)
(Mitochondrial ATP-binding cassette 2) (M-ABC2)
Length = 738
Score = 298 bits (763), Expect = 5e-80
Identities = 188/550 (34%), Positives = 297/550 (53%), Gaps = 66/550 (12%)
Query: 64 LGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGITSFLQVSCWMVTGERQSARIRSLY 123
LGK+I+ ++ + + ++++ L + + + ++V +G+R R+R+
Sbjct: 192 LGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSL 251
Query: 124 LKTILKQDIAFFDTETNTGEVISRMSGDTILIQEAMGEKVGKFLQLGSTFFGGFVIAFIK 183
+IL+Q++AFFD +T TGE+I+R+S DT L+ ++ E + L+ G+ G + F
Sbjct: 252 FSSILRQEVAFFD-KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFV 310
Query: 184 GWRLALVLLACVPCIVVAGAFMAMVMAKMAIRGQVAYAEAGNVANQTVGSMRTVASFTGE 243
LA +L+ VP + + + K+ Q + A+A +A + +G++RTV +F E
Sbjct: 311 SPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKE 370
Query: 244 KKAIEKYNSKIKIAYTAMVQQSIA-------SGIGMGTLLLIIFCSYGLAMWYGSKLVIA 296
IEKY SK+ ++++A +G+ ++L + GL M V
Sbjct: 371 MTEIEKYASKVDHVMQLARKEAVARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTV-- 428
Query: 297 KGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAYKMFETIKRKPKIDAYDTSGL 356
G + + ++ +S+G S G A +++E ++R+PK+ + L
Sbjct: 429 -----GELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVIL 483
Query: 357 VLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTTALVGQSGSGKSTVISLLERF 416
+ +G +E ++VHF YPARP+V IF FSL +PSG+ TALVG SGSGKSTV+SLL R
Sbjct: 484 NEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRL 543
Query: 417 YDPNAGEVLIDGVNLKNLQLRWIREQIGLVSQE--------------------------- 449
Y+P +G + +DG +++ L W+R +IG VSQE
Sbjct: 544 YNPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEI 603
Query: 450 ------------------------RQNGTQLSGGQKQRIAIARAILKNPKILLLDEATSA 485
+ G LSGGQKQRIAIARA+LKNPKILLLDEATSA
Sbjct: 604 QRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSA 663
Query: 486 LDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQQGKIVERGTHSELTMDPH 545
LDAE+E++VQEAL++++ RT +V+AHRL+TI +A+ +AV+ QGKI E G H EL P+
Sbjct: 664 LDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPN 723
Query: 546 GAYSQLIRLQ 555
G Y +L+ Q
Sbjct: 724 GIYRKLMNKQ 733
Score = 285 bits (730), Expect = 4e-76
Identities = 149/325 (45%), Positives = 213/325 (64%), Gaps = 2/325 (0%)
Query: 757 IFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPDTNKAIDSAASIFNILDSK 816
+ Y G +L+ T E+ +S+ S+ + + K + + ++ +L+ +
Sbjct: 413 VLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
Query: 817 PDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLTLSIPSAKTVALVGESGSG 876
P + + + +++ G +E ++V+F+YP RP++ IF+D +LSIPS ALVG SGSG
Sbjct: 473 PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532
Query: 877 KSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQMGLVGQEPILFNESIRANIAYGK 936
KSTV+SLL R Y+P SG + LDG DI+ WLR ++G V QEPILF+ SI NIAYG
Sbjct: 533 KSTVLSLLLRLYNPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGA 592
Query: 937 ED--GATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLSGGQKQRIAIARAMLKNP 994
+D T +EI A ANA FI + P G++T VGE+G LSGGQKQRIAIARA+LKNP
Sbjct: 593 DDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNP 652
Query: 995 KILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTIRGADTIAVIKNGMVAEK 1054
KILLLDEATSALDAE+E +VQEALDR+ RT +++AHRL+TI+ A+ +AV+ G + E
Sbjct: 653 KILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEY 712
Query: 1055 GRHDELMNNTHGVYASLVALHSTAS 1079
G+H+EL++ +G+Y L+ S S
Sbjct: 713 GKHEELLSKPNGIYRKLMNKQSFIS 737
Score = 32.7 bits (73), Expect = 5.4
Identities = 19/77 (24%), Positives = 38/77 (48%), Gaps = 5/77 (6%)
Query: 670 FLFSAVISMFYKPPEQQRKESRFWSLVYVGLGLVTL---VVFPLKNYFFGTAGGKLIERI 726
F +I + Y P ++ + + +GL V L ++ Y T+G +++ R+
Sbjct: 190 FFLGKIIDVIYTNPTVDYSDNL--TRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRL 247
Query: 727 RSLTFAKIVHQEIRWFD 743
R+ F+ I+ QE+ +FD
Sbjct: 248 RTSLFSSILRQEVAFFD 264
>ABC8_HUMAN (Q9NUT2) ATP-binding cassette, sub-family B, member 8,
mitochondrial precursor (Mitochondrial ATP-binding
cassette 1) (M-ABC1)
Length = 735
Score = 298 bits (762), Expect = 7e-80
Identities = 159/335 (47%), Positives = 220/335 (65%), Gaps = 3/335 (0%)
Query: 739 IRWFDDPAHSSLYCTNAFIFYIGSILVHHRKATFVEIFRVFFSLTMTAMSVSQSSTLFPD 798
I F ++ + C +IG LV ++ T ++ + S++ S LF
Sbjct: 375 IALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQ 434
Query: 799 TNKAIDSAASIFNILDSKPDIDSSSNDGVTQETVVGNIELQHVNFSYPTRPDIQIFKDLT 858
+ + + A +F + P I S V +E + G++ Q+V FSYP RP ++ KD T
Sbjct: 435 VVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFT 494
Query: 859 LSIPSAKTVALVGESGSGKSTVISLLERFYDPNSGRVLLDGVDIKTFRISWLRQQM-GLV 917
L++P K VALVG+SG GK+TV SLLERFYDP +G V+LDG D++T SWLR Q+ G +
Sbjct: 495 LTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFI 554
Query: 918 GQEPILFNESIRANIAYGKEDGATEDEIIAAANAANAHNFISSLPDGYDTSVGERGTQLS 977
QEP+LF +I NI +GK + A+++E+ AA ANAH FI+S P+GY+T VGERGT LS
Sbjct: 555 SQEPVLFGTTIMENIRFGKLE-ASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLS 613
Query: 978 GGQKQRIAIARAMLKNPKILLLDEATSALDAESERIVQEALDRVSLNRTTVIVAHRLTTI 1037
GGQKQR+AIARA++K P +L+LDEATSALDAESER+VQEALDR S RT +++AHRL+T+
Sbjct: 614 GGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTV 673
Query: 1038 RGADTIAVIKNGMVAEKGRHDELMNNTHGVYASLV 1072
RGA I V+ +G V E G H+EL+ G+YA L+
Sbjct: 674 RGAHCIVVMADGRVWEAGTHEELLKK-GGLYAELI 707
Score = 271 bits (693), Expect = 7e-72
Identities = 184/590 (31%), Positives = 294/590 (49%), Gaps = 65/590 (11%)
Query: 42 LMIIGTISAMANGFA--SPLMTLLLGKVINAFGSSNQSEVLNQVSKVSLLFVYLAIGSGI 99
L+++G +A G A + + LLLG+++ + V + +++ L +L I G+
Sbjct: 145 LLVLGVAVVLALGAALVNVQIPLLLGQLVKVVAKYTRDHVGSFMTESQNLSTHLLILYGV 204
Query: 100 TSFLQVSCWMV---TGERQSARIRSLYLKTILKQDIAFFDTETNTGEVISRMSGDTILIQ 156
L ++ GER + +R ++L+Q+I FFD TG+++SR++ D +
Sbjct: 205 QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQNITFFDAN-KTGQLVSRLTTDVQEFK 263
Query: 157 EAMGEKVGKFLQLGSTFFGGFVIAFIKGWRLALVLLACVPCIVVAGAFMAMVMAKMAIRG 216
+ + + L+ S G V + RL L+L+ P ++ G M + K++ +
Sbjct: 264 SSFKLVISQGLRSCSQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQC 323
Query: 217 QVAYAEAGNVANQTVGSMRTVASFTGEKKAIEKYNSKIKIAYTAMVQQSIASGIGMGTLL 276
Q A A VA++ +G++RTV + E++ E+Y ++++ + + G
Sbjct: 324 QEHIARAMGVADEALGNVRTVRALAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN 383
Query: 277 LIIFCSYGLAMWYGSKLVIAKGYNGGTVMTVVIALVTGSMSLGQTSPSLHAFAAGKAAAY 336
+ C ++ G LV + GG +M+ ++A T S+ S G +A
Sbjct: 384 IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGA 443
Query: 337 KMFETIKRKPKIDAYDTSGLVLEDIKGDIELRDVHFRYPARPDVEIFAGFSLFVPSGTTT 396
++FE + P I + E ++G + ++V F YP RP E+ F+L +P G
Sbjct: 444 RVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIV 503
Query: 397 ALVGQSGSGKSTVISLLERFYDPNAGEVLIDGVNLKNLQLRWIREQ-IGLVSQE------ 449
ALVGQSG GK+TV SLLERFYDP AG V++DG +L+ L W+R Q +G +SQE
Sbjct: 504 ALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT 563
Query: 450 ------------------------------------------RQNGTQLSGGQKQRIAIA 467
+ GT LSGGQKQR+AIA
Sbjct: 564 TIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIA 623
Query: 468 RAILKNPKILLLDEATSALDAESEHIVQEALEKIILKRTTIVVAHRLTTIIHADTIAVVQ 527
RA++K P +L+LDEATSALDAESE +VQEAL++ RT +V+AHRL+T+ A I V+
Sbjct: 624 RALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMA 683
Query: 528 QGKIVERGTHSELTMDPHGAYSQLIRLQEGE---------KEAEGSRSSE 568
G++ E GTH EL + G Y++LIR Q + K+ EG RS +
Sbjct: 684 DGRVWEAGTHEEL-LKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQ 732
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.319 0.134 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114,804,414
Number of Sequences: 164201
Number of extensions: 4723904
Number of successful extensions: 22270
Number of sequences better than 10.0: 1020
Number of HSP's better than 10.0 without gapping: 884
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 16913
Number of HSP's gapped (non-prelim): 4048
length of query: 1079
length of database: 59,974,054
effective HSP length: 121
effective length of query: 958
effective length of database: 40,105,733
effective search space: 38421292214
effective search space used: 38421292214
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Medicago: description of AC140022.3