BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC139706.5 - phase: 0 
         (424 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

YEIA_ECOLI (P25889) Hypothetical protein yeiA                         252  1e-66
DPYD_CAEEL (Q18164) Probable dihydropyrimidine dehydrogenase [NA...   227  5e-59
DPYD_HUMAN (Q12882) Dihydropyrimidine dehydrogenase [NADP+] prec...   226  9e-59
DPYD_PIG (Q28943) Dihydropyrimidine dehydrogenase [NADP+] precur...   222  2e-57
DPYD_BOVIN (Q28007) Dihydropyrimidine dehydrogenase [NADP+] (EC ...   219  1e-56
PYRD_PYRHO (O59185) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   135  2e-31
PYRD_METJA (Q58070) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   130  6e-30
PYRD_PYRAB (Q9V0Y6) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   129  1e-29
PYRD_THEVO (Q979G6) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   129  1e-29
PYRD_PYRFU (Q8U0P6) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   125  2e-28
PYRD_METTH (O27281) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   120  5e-27
PYRD_THEAC (Q9HL35) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   113  1e-24
PYRD_METMA (Q8PW56) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   109  1e-23
PYRD_AQUAE (O66461) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   106  1e-22
PYRD_METAC (Q8TT55) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   100  5e-21
PYRD_LACPL (P77887) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...   100  1e-20
PYDB_LACLA (Q9CFW8) Dihydroorotate dehydrogenase B, catalytic su...    98  4e-20
PYRD_BACSU (P25996) Dihydroorotate dehydrogenase, catalytic subu...    97  8e-20
PYRD_OCEIH (Q8CWG1) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...    97  1e-19
PYRD_LISIN (Q92AH5) Dihydroorotate dehydrogenase (EC 1.3.3.1) (D...    97  1e-19

>YEIA_ECOLI (P25889) Hypothetical protein yeiA
          Length = 411

 Score =  252 bits (643), Expect = 1e-66
 Identities = 141/338 (41%), Positives = 201/338 (58%), Gaps = 13/338 (3%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYA 107
           DLS+   G+  PNPF + S P G  Y +  +A+D GWGGV+ KT+    A    V+PR+ 
Sbjct: 5   DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSPRFD 62

Query: 108 RLRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAW 167
            L     G      IG++N+E I++ PLE  L   ++LKE+YPD++LIASIM E N+  W
Sbjct: 63  HLVKEDTG-----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQW 116

Query: 168 EELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKM 227
           EEL   V++ G D IE NFSCP  M    MG+ VGQ   L+E+ C  +   +T+P+ AKM
Sbjct: 117 EELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175

Query: 228 TPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAVH 287
           TPNI D+ + A  A   G +G+AAINT+ S+  I+LN     P V G S+  GYS KAV 
Sbjct: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235

Query: 288 PIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYG 347
           PIAL       + M++  +  ++ +S IGG+ET  DAAEF+LLGA T+QV TG+M +GY 
Sbjct: 236 PIAL----RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291

Query: 348 LVKKLSLELKDFMKKHNFTSIEDFRGASLQYFTTHTDL 385
           +V+ ++  L  ++    F S+++  G +        DL
Sbjct: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDL 329


>DPYD_CAEEL (Q18164) Probable dihydropyrimidine dehydrogenase
           [NADP+] (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil
           dehydrogenase) (Dihydrothymine dehydrogenase)
          Length = 1084

 Score =  227 bits (578), Expect = 5e-59
 Identities = 127/338 (37%), Positives = 190/338 (55%), Gaps = 18/338 (5%)

Query: 44  VSEPDLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVT 103
           + E D+SV + G+   NPF + S PP T+  + +RAF++GWG ++ KT  LD   V NV+
Sbjct: 567 IDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVS 626

Query: 104 PRYARLRANANGSAKGEIIG-----WQNIELISDRPLETMLKEFKQLKEEYPDRILIASI 158
           PR  R      GS  G + G     + NIELIS++  E  L+  ++LK ++P +I+IASI
Sbjct: 627 PRIVR------GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASI 680

Query: 159 MEEYNKAAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAK 218
           M  YNKA W EL  + E+ G D +E+N SCPHGM E+ MG A GQ   +++E+C W+ A 
Sbjct: 681 MCVYNKADWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRAC 740

Query: 219 ATVPVWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLN-TLRPEPCVEGYST 277
             +P + KMTPNITD+ + AR A   G  GV A NT+ S+M +  +    P       +T
Sbjct: 741 VKIPFFPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTT 800

Query: 278 PGGYSAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQV 337
            GG S  A+ PIA+  V SIA       + + + + A GG+E+      F++ GA+ +QV
Sbjct: 801 YGGMSGSAIRPIAMKAVSSIAN------ELDGFPIMATGGIESAETGLGFLMAGASVLQV 854

Query: 338 CTGVMMHGYGLVKKLSLELKDFMKKHNFTSIEDFRGAS 375
           C+ V    + +V      LK  +      S++++ G S
Sbjct: 855 CSAVQNQDFTVVDDYCTGLKALLYLSGAESLKNWDGQS 892


>DPYD_HUMAN (Q12882) Dihydropyrimidine dehydrogenase [NADP+]
           precursor (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil
           dehydrogenase) (Dihydrothymine dehydrogenase)
          Length = 1025

 Score =  226 bits (576), Expect = 9e-59
 Identities = 125/334 (37%), Positives = 187/334 (55%), Gaps = 18/334 (5%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYA 107
           D+SV++ GL   NPF + S  P T+ ++++RAF+ GWG  + KT SLD   V NV+PR  
Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRII 591

Query: 108 RLRANANGSAKGEIIG-----WQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEY 162
           R      G+  G + G     + NIELIS++      +   +LK ++PD I+IASIM  Y
Sbjct: 592 R------GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSY 645

Query: 163 NKAAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVP 222
           NK  W EL  + E +G DA+E+N SCPHGM ER MG A GQD  L+  +C W+     +P
Sbjct: 646 NKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIP 705

Query: 223 VWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLN-TLRPEPCVEGYSTPGGY 281
            +AK+TPN+TDI   AR A   G  GV A NT+  +MG+  + T  P   +   +T GG 
Sbjct: 706 FFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGV 765

Query: 282 SAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGV 341
           S  A+ PIAL  V SIA+ +        + + A GG+++     +F+  GA+ +QVC+ +
Sbjct: 766 SGTAIRPIALRAVTSIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAI 819

Query: 342 MMHGYGLVKKLSLELKDFMKKHNFTSIEDFRGAS 375
               + +++     LK  +   +   ++D+ G S
Sbjct: 820 QNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQS 853


>DPYD_PIG (Q28943) Dihydropyrimidine dehydrogenase [NADP+] precursor
           (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil
           dehydrogenase) (Dihydrothymine dehydrogenase)
          Length = 1025

 Score =  222 bits (565), Expect = 2e-57
 Identities = 132/382 (34%), Positives = 202/382 (52%), Gaps = 20/382 (5%)

Query: 1   MANLSMTQLKTRNSASRFSFNFSKKVYPRPSRVDFKVFASEGQVSEPDLSVKVNGLHMPN 60
           MAN ++  +     AS +   + +  Y        ++      V   D+SV++ GL   N
Sbjct: 485 MANTTVESVNDGKQASWYIHKYIQAQYGASVSAKPELPLFYTPVDLVDISVEMAGLKFIN 544

Query: 61  PFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYARLRANANGSAKGE 120
           PF + S  P T+ ++++RAF+ GWG  + KT SLD   V NV+PR  R      G+  G 
Sbjct: 545 PFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIVR------GTTSGP 598

Query: 121 IIG-----WQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWEELIDRVE 175
           + G     + NIELIS++      +   +LK ++PD I+IASIM  YNK  W EL  + E
Sbjct: 599 MYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWMELSRKAE 658

Query: 176 QTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDIS 235
            +G DA+E+N SCPHGM ER MG A GQD  L+  +C W+     +P +AK+TPN+TDI 
Sbjct: 659 ASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIV 718

Query: 236 QPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEG--YSTPGGYSAKAVHPIALGK 293
             AR A   G +GV A NT+  +MG+  +   P P V     +T GG S  A+ PIAL  
Sbjct: 719 SIARAAKEGGADGVTATNTVSGLMGLKADG-TPWPAVGAGKRTTYGGVSGTAIRPIALRA 777

Query: 294 VMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYGLVKKLS 353
           V +IA+ +        + + A GG+++     +F+  GA+ +QVC+ V    + +++   
Sbjct: 778 VTTIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIQDYC 831

Query: 354 LELKDFMKKHNFTSIEDFRGAS 375
             LK  +   +   ++ + G S
Sbjct: 832 TGLKALLYLKSIEELQGWDGQS 853


>DPYD_BOVIN (Q28007) Dihydropyrimidine dehydrogenase [NADP+] (EC
           1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil dehydrogenase)
           (Dihydrothymine dehydrogenase)
          Length = 1025

 Score =  219 bits (558), Expect = 1e-56
 Identities = 123/335 (36%), Positives = 186/335 (54%), Gaps = 20/335 (5%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYA 107
           D+SV++  L   NPF + S  P T+ ++++RAF+ GW   + KT SLD   V NV+PR  
Sbjct: 532 DISVEMAALKFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTNVSPRII 591

Query: 108 RLRANANGSAKGEIIG-----WQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEY 162
           R      G+  G + G     + NIELIS++      +   +LK ++PD I+IASIM  Y
Sbjct: 592 R------GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSY 645

Query: 163 NKAAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVP 222
           N+  W EL  + E +G DA+E+N SCPHGM ER MG A GQD  L+  +C W+     +P
Sbjct: 646 NRNDWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIP 705

Query: 223 VWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCV--EGYSTPGG 280
            +AK+TPN+TDI   AR A   G  GV A NT+  +MG+  +   P P V  E  +T GG
Sbjct: 706 FFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKADG-TPWPAVGREKRTTYGG 764

Query: 281 YSAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTG 340
            S  A+ PIAL  V +IA+ +        + + A GG+++     +F+  GA+ +QVC+ 
Sbjct: 765 VSGTAIRPIALRAVTTIARAL------PEFPILATGGIDSAESGLQFLHGGASVLQVCSA 818

Query: 341 VMMHGYGLVKKLSLELKDFMKKHNFTSIEDFRGAS 375
           +    + +++     LK  +   +   ++D+ G S
Sbjct: 819 IQNQDFTIIQDYCTGLKALLYLKSIEELQDWDGQS 853


>PYRD_PYRHO (O59185) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 303

 Score =  135 bits (340), Expect = 2e-31
 Identities = 98/329 (29%), Positives = 162/329 (48%), Gaps = 32/329 (9%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L VK+ G+   NP ++ SG       +++RA +EG GGV+ K++  +  K  +  P    
Sbjct: 6   LEVKLFGIRFENPLILASGVVDMTPELLRRAHNEGAGGVVTKSIGKEPRKGYD-NPTIVE 64

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWE 168
           L      +      GW           E  L EF   + ++P  + I     E     + 
Sbjct: 65  LPYGLINAMGLPNPGW-----------EAFLNEFIDERFDFPVIVSIFGGTPE----EFA 109

Query: 169 ELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMT 228
            L +++E    DA E+N SCPH    +  G  +GQD   + EV   +      PV AK+T
Sbjct: 110 FLAEKLEPVA-DAFELNLSCPHA---KGYGMEIGQDPKNVYEVVKAVKDVTDKPVIAKLT 165

Query: 229 PNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAVHP 288
           PN+ DI++    A   G +GV+AINT+ ++  I++   RP       +  GGYS   + P
Sbjct: 166 PNVNDITKLGLAAERGGADGVSAINTVKAI-AIDIYAKRPILS----NKVGGYSGPGIKP 220

Query: 289 IALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYGL 348
           IAL  V  +AK++       +  +  IGG+ +  DA EF+L GA+ +Q+ T V + G+ +
Sbjct: 221 IALRAVYDLAKVL-------DIPVIGIGGITSWRDAVEFLLAGASALQIGTAVYLRGFKV 273

Query: 349 VKKLSLELKDFMKKHNFTSIEDFRGASLQ 377
            K++S  + +++K+  F+SI D  G +L+
Sbjct: 274 FKEISNGIIEYLKEEGFSSIRDIIGLALK 302


>PYRD_METJA (Q58070) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 306

 Score =  130 bits (327), Expect = 6e-30
 Identities = 93/325 (28%), Positives = 163/325 (49%), Gaps = 41/325 (12%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L   + G+   NP  + SG  G   + +KR    G G V  K++ L              
Sbjct: 6   LKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGL-------------- 51

Query: 109 LRANANGSAKGEII-----GWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYN 163
              N N   K   I     G+ N   + +  ++  L+E +++++E  +R+ +  I   Y 
Sbjct: 52  ---NPNPGHKNPTIVEVYGGFLNAMGLPNPGVDEYLEEIEKVRDEL-NRMDVRIIGSIYG 107

Query: 164 KAAWE--ELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATV 221
           K   E  E+  ++E+  +D IE+N SCPH    +  GA +GQ+  L  +VC  +     +
Sbjct: 108 KDEEEFAEVAKKMERY-VDIIELNISCPHA---KGYGATIGQNPDLSYDVCKAVKKAVKI 163

Query: 222 PVWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGY 281
           PV+AK+TPN+TDI + A+  + +G +G+ AINT+   M I++   +P       +  GG 
Sbjct: 164 PVFAKLTPNVTDIIEIAQAVVDAGVDGLVAINTVRG-MAIDIRAKKPILA----NKFGGL 218

Query: 282 SAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGV 341
           S KA+  I +       K++   +++ +  +  +GG+ +G DA E+++ GA+ VQ+ +GV
Sbjct: 219 SGKAIKSIGI-------KVVWDLYENFDVPIIGVGGIMSGEDAIEYMMAGASAVQIGSGV 271

Query: 342 MMHGYGLVKKLSLELKDFMKKHNFT 366
              GY + KK+  E+  F+K+ N T
Sbjct: 272 YYRGYDIFKKVCDEIISFLKEENLT 296


>PYRD_PYRAB (Q9V0Y6) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 303

 Score =  129 bits (325), Expect = 1e-29
 Identities = 96/331 (29%), Positives = 161/331 (48%), Gaps = 36/331 (10%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L V + G+   NP ++ SG       +++RA  EG GGV+ K++ ++  K     P    
Sbjct: 6   LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYE-NPTIVE 64

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWE 168
           L      +      GW           E  L+EF++ K ++P   +I SI         E
Sbjct: 65  LPYGLINAMGLPNPGW-----------EAFLEEFRKEKFDFP---VIVSIFG----GTPE 106

Query: 169 ELIDRVEQTG--IDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAK 226
           E     E+ G   DA E+N SCPH    +  G  +GQ    + EV   +      PV AK
Sbjct: 107 EFAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163

Query: 227 MTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAV 286
           +TPN++DI +    A  +G +GV+AINT+ ++  I++   RP       +  GGYS   V
Sbjct: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVKAI-AIDIYAKRPILS----NKFGGYSGPGV 218

Query: 287 HPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGY 346
            PIAL  V  +A  +       +  +  IGG+ T  DA EF+L GA+ +Q+ T V + G+
Sbjct: 219 KPIALRAVYDLASSL-------DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGF 271

Query: 347 GLVKKLSLELKDFMKKHNFTSIEDFRGASLQ 377
            + ++++  +  ++K+  ++S+++  G +L+
Sbjct: 272 SVFREIAEGISRYLKEEGYSSVKEIIGLALK 302


>PYRD_THEVO (Q979G6) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 301

 Score =  129 bits (324), Expect = 1e-29
 Identities = 93/332 (28%), Positives = 162/332 (48%), Gaps = 36/332 (10%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAK--VINVTPR 105
           D+S  + G+ + NPF++ SG    N   MK   + G   V+ K++ +         V   
Sbjct: 3   DISTTLAGIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPTPVIVE 62

Query: 106 YARLRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKA 165
           Y     NA G              +S+  +E   +E    KE    R +I S+   YN  
Sbjct: 63  YGDSLINAVG--------------LSNPGIENFGEEINIAKEA--KRPIIGSVFA-YNAE 105

Query: 166 AWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWA 225
            + +L  ++E+ G+DAIE+N SCPH    +  G  VG D  L+E++   I +K  VPV+A
Sbjct: 106 EFTKLSVKMEEYGVDAIELNLSCPH---VKGFGLEVGSDPDLVEDIVNEIKSKVKVPVFA 162

Query: 226 KMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKA 285
           K++PN+++I + A+ A  +  +    INT+ + M I++ +  P       +  GG S  A
Sbjct: 163 KLSPNVSNIIEIAKAAEKA--DAYVLINTVKA-MAIDIYSRSPVLS----NLYGGLSGPA 215

Query: 286 VHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHG 345
           + P+ +  V  + K    E       +  +GG+    DA E+I+ GA+ VQ+ T +  +G
Sbjct: 216 IKPVGIRYVYEVKKETGKE-------IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYG 268

Query: 346 YGLVKKLSLELKDFMKKHNFTSIEDFRGASLQ 377
            G+ +++  +L+ FM +  F  IE+  G +++
Sbjct: 269 KGIFREMEWQLRTFMDEERFEKIEEMVGVAIK 300


>PYRD_PYRFU (Q8U0P6) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 300

 Score =  125 bits (314), Expect = 2e-28
 Identities = 89/325 (27%), Positives = 163/325 (49%), Gaps = 32/325 (9%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           + +++ G+   NP ++ SG       +++RA  EG GGV+ K++ ++  K  +  P    
Sbjct: 3   IKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYD-NPTVVE 61

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWE 168
           +      +      GW+             L+EF++   ++P   +I SI    N   + 
Sbjct: 62  VPCGLINAMGLPNPGWK-----------AFLEEFEKESFDFP---VIVSIFGG-NPEEFA 106

Query: 169 ELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMT 228
            L +++E+ G DA E+N SCPH    +  G  +GQD   +  V   +      PV AK+T
Sbjct: 107 FLAEKLERVG-DAFELNLSCPHA---KGYGLEIGQDPENVYRVVKAVKDVTDKPVIAKLT 162

Query: 229 PNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAVHP 288
           PN +DI++    A  +  +GV+AINT+ ++  I++   RP       +  GGYS   + P
Sbjct: 163 PNTSDITKLGLAAEKAEADGVSAINTLKAI-AIDIYAKRPILS----NKFGGYSGPGIKP 217

Query: 289 IALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYGL 348
           IAL  V  +A  +       +  +  IGG+ T  DA EF+L GA+ VQ+ T V + G+ +
Sbjct: 218 IALRAVYDLASKL-------DIPIIGIGGITTWQDAVEFLLAGASAVQIGTAVYLKGFSV 270

Query: 349 VKKLSLELKDFMKKHNFTSIEDFRG 373
            ++++  ++ ++++  F+S+++  G
Sbjct: 271 FREIAEGIRKYLEEEGFSSVKEIIG 295


>PYRD_METTH (O27281) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 303

 Score =  120 bits (302), Expect = 5e-27
 Identities = 100/329 (30%), Positives = 154/329 (46%), Gaps = 38/329 (11%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L   +  + + NP ++ +G  G+  + + R +  G G V+ K+ SL         P Y  
Sbjct: 5   LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSL------RPNPGY-- 56

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIM----EEYNK 164
            R        G +I   N   +S+  +E   +E K + EE P   LIAS+     EE+  
Sbjct: 57  -RNPTTVEVTGGVI---NAIGLSNPGVEAFREELKLVDEEVP---LIASVYGASPEEFAS 109

Query: 165 AAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVW 224
           AA       VE+   D IE+N SCPH M     GA++GQD  L   V   +     VP+ 
Sbjct: 110 AAAS-----VEEYA-DMIELNVSCPHAMAG--CGASIGQDPELTFRVVSAVKDAVDVPIS 161

Query: 225 AKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAK 284
            K+TPN+TDI + A  A  +G + +  IN++   M I++ T RP       +  GG S  
Sbjct: 162 TKLTPNVTDIVEIAGSAEEAGSDALTLINSLGPGMKIDIKTARPILS----NAFGGMSGP 217

Query: 285 AVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMH 344
           A+ P+A+  V  +       + S +  +  +GGV    DA EF+  GA  VQV T +M  
Sbjct: 218 AIKPVAVRCVYDV-------YRSVDIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYD 270

Query: 345 GYGLVKKLSLELKDFMKKHNFTSIEDFRG 373
           G  +  K+   L+ FM    F+S+++  G
Sbjct: 271 GPEVFMKICRGLEAFMMAEGFSSVDEMVG 299


>PYRD_THEAC (Q9HL35) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 300

 Score =  113 bits (282), Expect = 1e-24
 Identities = 86/332 (25%), Positives = 157/332 (46%), Gaps = 36/332 (10%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVIN--VTPR 105
           DLS  V G+ + NP ++ SG    N   M    + G   V+ K++ ++     +  V   
Sbjct: 3   DLSTSVAGIRLENPLMLASGILDENGYTMLDVMNNGAAAVVTKSIGMEERNGYSAPVIVE 62

Query: 106 YARLRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKA 165
           Y     NA G              +S+  ++   +E +  K     + +I S+    +  
Sbjct: 63  YGDSLINAVG--------------LSNPGIDNFAEEIRIAKRS--GKPVIGSVFAS-DAE 105

Query: 166 AWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWA 225
           ++  L  ++++ G DA+E+N SCPH    +  G  VG D  L+E++   + +K +VPV+A
Sbjct: 106 SFVNLGRKMQEYGCDAVELNLSCPH---VKGFGLEVGSDPDLVEDIVNEMKSKISVPVFA 162

Query: 226 KMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKA 285
           K++PN++DI + A+ A  +  +    INT+ + M I++    P      Y   GG S  A
Sbjct: 163 KLSPNVSDIIEIAKAAEKA--DAYVLINTVKA-MKIDIRARMPV-LTNAY---GGLSGPA 215

Query: 286 VHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHG 345
           + P+ +  V  + K    +       +  +GG+ T  DA E+I+ GA+ VQ+ T +   G
Sbjct: 216 IKPVGVRYVYEVKKETGKD-------IIGVGGITTYEDAVEYIMAGASAVQIGTALYTVG 268

Query: 346 YGLVKKLSLELKDFMKKHNFTSIEDFRGASLQ 377
             + + +  ++  FM    F SI+D  G +++
Sbjct: 269 KSVFRNIISQMNTFMDDEKFHSIQDMVGVAIR 300


>PYRD_METMA (Q8PW56) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 314

 Score =  109 bits (273), Expect = 1e-23
 Identities = 94/325 (28%), Positives = 146/325 (44%), Gaps = 29/325 (8%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L   + GL + NP ++ +G  GT    + R   EG  G +       A K  +  P    
Sbjct: 13  LMYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIE 72

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWE 168
           L             G+ N   + +      L+E +  KE   D  +IASI      + + 
Sbjct: 73  LDC-----------GFLNAMGLPNPSYPGFLQELEFAKEN-SDAPVIASIFGG-TPSEFA 119

Query: 169 ELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMT 228
           E+ + +     DA E+N SCPH       GAA+G +  L+E V   +     VPVW K+T
Sbjct: 120 EVAEGLLPAKPDAFELNVSCPHA---EGYGAAIGSNPCLVEAVTAAVKDVVNVPVWVKLT 176

Query: 229 PNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAVHP 288
           PN+ DI+     A S G + V AINT+   M I++ +  P   V G +  GG S KAV P
Sbjct: 177 PNVADITCIGNAAESGGADAVVAINTVKG-MAIDIESGYP---VLG-NRSGGLSGKAVKP 231

Query: 289 IALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYGL 348
           +A+       K +   F +    +  +GGV +  DA E I+ GA  VQV + V     G+
Sbjct: 232 VAV-------KCVYDLFTALEIPVIGVGGVSSWEDAVEMIMAGAAAVQVGSAV-YDRVGI 283

Query: 349 VKKLSLELKDFMKKHNFTSIEDFRG 373
             ++   ++ F+K+  ++ I+   G
Sbjct: 284 FSEIGKGIEAFLKRKGYSDIKKITG 308


>PYRD_AQUAE (O66461) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 306

 Score =  106 bits (265), Expect = 1e-22
 Identities = 93/326 (28%), Positives = 155/326 (47%), Gaps = 32/326 (9%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYA 107
           DLSV++ G+   NP  + SG  G      +       G V+ K +SL   ++ N TPR  
Sbjct: 2   DLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKE-RLGNETPRIV 60

Query: 108 RLRANANGSAKGEIIGWQNIELISDRPLETMLKE-FKQLKEEYPDRILIASIMEEYNKAA 166
                   S     IG QN        +E  LKE + ++K+   D   IA++  E  +  
Sbjct: 61  ETPCGMLNS-----IGLQN------PGVEKFLKEIYPKIKDV--DTHFIANVFGETEEEY 107

Query: 167 WEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAK 226
            E  +   +   I A E+N SCP+    +K G   G D  +L  +   I AK   P+  K
Sbjct: 108 VEVCMALEDADKIVAYELNVSCPN---VKKGGILFGHDPVILGNLVDRIKAKIKKPLLVK 164

Query: 227 MTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAV 286
           ++PN+TD+++ A+V + +G +G+  INT+   MG+ +N  + +P +   +  GG S  A+
Sbjct: 165 LSPNVTDVTEFAKVCIENGADGLVLINTL---MGMKINIWKRKPDLA--TKTGGLSGPAI 219

Query: 287 HPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGY 346
            PIA+  +  + +        +   +  +GG+ T  DA E ++ GA+ VQV T       
Sbjct: 220 LPIAVRMIYQVYEKF-----GDRIPIIGVGGITTWEDAMEHVMAGASAVQVGTANFYEPL 274

Query: 347 GLVKKLSLELKDFMKKHNFTSIEDFR 372
             +K +   +++FMK  N   I+DF+
Sbjct: 275 APLKVIE-GIENFMKSQN---IKDFK 296


>PYRD_METAC (Q8TT55) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 311

 Score =  100 bits (250), Expect = 5e-21
 Identities = 89/323 (27%), Positives = 145/323 (44%), Gaps = 29/323 (8%)

Query: 53  VNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYARLRAN 112
           + GL + NP ++ +G  GT    + R   EG  G +       A K  +  P   +L   
Sbjct: 14  LTGLELKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHSNPSMIKLDC- 72

Query: 113 ANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASIMEEYNKAAWEELID 172
                     G+ N   + +      L+E +  K      + IASI      + + E+ +
Sbjct: 73  ----------GFLNAMGLPNPSYPGFLQELEFAKNNSAVPV-IASIFGGA-PSEFAEVAE 120

Query: 173 RVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMTPNIT 232
            +     DA+E+N SCPH       GAAVG +  L+E V   +     VPVW K+TPN+ 
Sbjct: 121 GLLPAKPDALELNVSCPHA---EGYGAAVGSNPCLVEAVTAAVKDVVNVPVWVKLTPNVA 177

Query: 233 DISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKAVHPIALG 292
           DI+     A S G + V AINT+   M I++ +  P   V G +  GG S KAV P+A+ 
Sbjct: 178 DITCIGNAAESGGADAVVAINTVKG-MAIDIESGYP---VLG-NRSGGLSGKAVKPVAV- 231

Query: 293 KVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHGYGLVKKL 352
                 K +   + +    +  +GGV +  DA E ++ GA  VQV + V      +  ++
Sbjct: 232 ------KCVYDLYTALEIPVIGVGGVSSWEDAVELMMAGAAAVQVGSAV-YDRVDIFSEI 284

Query: 353 SLELKDFMKKHNFTSIEDFRGAS 375
              ++ F+++  ++ I+   G S
Sbjct: 285 GAGIEAFLERKGYSDIQKIIGLS 307


>PYRD_LACPL (P77887) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 305

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 90/304 (29%), Positives = 134/304 (43%), Gaps = 42/304 (13%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L+V + G+   NP +  SG       + ++      GG++ K+ + +  K  N  P  A 
Sbjct: 4   LTVNLAGVTFKNPVMPASGTAAYGQQMAQQLDLSALGGLVIKSTTAEP-KAGNPRPTTAE 62

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKE-FKQLKEEYPDRILIASI----MEEYN 163
             A           GW N   + +  ++ +L +    L   YPD  +I S+     +EY 
Sbjct: 63  TTA-----------GWLNAIGLKNPGIDNVLADKLPWLATHYPDLPIIGSVAGASFDEYV 111

Query: 164 KAAWEELIDRVEQTGIDAIEINFSCP---HGMPERKMGAAVGQDCALLEEVCGWINAKAT 220
             A +          +  +EIN SCP   HG      G A G D A +  +   I A   
Sbjct: 112 AVARK----MASAPNVKLLEINISCPNVDHG------GLAFGTDPATVTALTKAIVAAVD 161

Query: 221 VPVWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGG 280
            PV+ K+TPN+TDI   A  A + G  G+  INT+   MGI+L T +P   +  + T GG
Sbjct: 162 KPVFMKLTPNVTDIVPIALAAEAGGAAGLTMINTLTG-MGIDLATRQP---ILAHGT-GG 216

Query: 281 YSAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTG 340
            S KA+HP+A+  +  + +  K         +  +GGV T  D  EF L GAN VQV   
Sbjct: 217 LSGKAIHPLAVRMIHDVRQHTK-------LPIIGVGGVFTPADVLEFYLAGANAVQVGAA 269

Query: 341 VMMH 344
              H
Sbjct: 270 TYGH 273


>PYDB_LACLA (Q9CFW8) Dihydroorotate dehydrogenase B, catalytic
           subunit (EC 1.3.3.1) (Dihydroorotate oxidase B)
           (DHOdehase B) (DHODase B) (DHOD B)
          Length = 311

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 92/326 (28%), Positives = 152/326 (46%), Gaps = 35/326 (10%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           LSVK+ GL + NP +  SG  G      K       G ++ K  +L   +  N TPR A 
Sbjct: 7   LSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHP-RFGNPTPRVAE 65

Query: 109 LRANANGSAKGEIIGWQN--IELISDRPLETMLKEFKQLKEEYPDRILIASIM--EEYNK 164
                  S     IG QN  +E+I       M ++   L E +PD  +IA++   EE + 
Sbjct: 66  -----TASGMLNAIGLQNPGLEVI-------MAEKLPWLNENFPDLPIIANVAGSEEDDY 113

Query: 165 AAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVW 224
            A    I   +   +  IE+N SCP+    +  G A G D  +   +     A + VP++
Sbjct: 114 VAVCAKIG--DAPNVKVIELNISCPN---VKHGGQAFGTDPDVAAALVKACKAVSKVPLY 168

Query: 225 AKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAK 284
            K++PN+TDI   A+   ++G +G+  INT+M V   +L T +P       +  GG S  
Sbjct: 169 VKLSPNVTDIVPIAKAVEAAGADGLTMINTLMGVR-FDLKTRKPVLA----NITGGLSGP 223

Query: 285 AVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMH 344
           A+ P+AL  +  +A+++       +  +  +GGVE+  D  E  + GA+ V V T     
Sbjct: 224 AIKPVALKLIHQVAQVV-------DIPIIGMGGVESAQDVLEMYMAGASAVAVGTANFAD 276

Query: 345 GYGLVKKLSLELKDFMKKHNFTSIED 370
            + +  K+  +L + M ++   S+E+
Sbjct: 277 PF-VCPKIIEKLPEVMDQYGIDSLEN 301


>PYRD_BACSU (P25996) Dihydroorotate dehydrogenase, catalytic subunit
           (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase)
           (DHODase) (DHOD)
          Length = 311

 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 92/331 (27%), Positives = 157/331 (46%), Gaps = 37/331 (11%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L VK+ GL + NP +  SG  G       R +D    G I    +    +  N TPR A 
Sbjct: 2   LEVKLPGLDLKNPIIPASGCFGFGKE-FSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAE 60

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRILIASI----MEEYNK 164
                 G+     IG QN  L  D  L   L   +Q      D  +IA++    +++Y +
Sbjct: 61  -----TGAGMLNAIGLQNPGL--DSVLHHELPWLEQF-----DTPIIANVAGSQVDDYVE 108

Query: 165 AAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVW 224
            A  E I +     + A+E+N SCP+    +  G A G +  +  ++   +   + VPV+
Sbjct: 109 VA--EHISKAPN--VHALELNISCPN---VKTGGIAFGTNPEMAADLTKAVKEVSDVPVY 161

Query: 225 AKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAK 284
            K++PN+ +I++ A     +G +G+  INT++  M ++L T +P       +  GG S  
Sbjct: 162 VKLSPNVANITEIALAIEEAGADGLTMINTLIG-MRLDLKTGKPILA----NKTGGLSGP 216

Query: 285 AVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMH 344
           AV P+A+  V  +++M+       N  +  +GGV+T  DA EF+L GA+ V V T   ++
Sbjct: 217 AVKPVAIRMVYEVSQMV-------NIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVN 269

Query: 345 GYGLVKKLSLELKDFMKKHNFTSIEDFRGAS 375
            +   + +  +L   + ++ + SIE+  G S
Sbjct: 270 PFACPEIIE-QLPSVLLQYGYQSIEECIGRS 299


>PYRD_OCEIH (Q8CWG1) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 304

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 87/329 (26%), Positives = 158/329 (47%), Gaps = 41/329 (12%)

Query: 48  DLSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYA 107
           +LSVK+ GL++ NP +  SG  G      +       GGV+ K  +    ++ N TPR A
Sbjct: 2   NLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAAT-QFERLGNPTPRVA 60

Query: 108 RLRANANGSAKGEIIGWQN--IELISDRPLETMLKEFKQLKEEYPDRILIASI----MEE 161
              A    +     IG QN  ++ I D  +  + K          D  +IA+I    +EE
Sbjct: 61  ETSAGMLNA-----IGLQNPGVQQIIDHEVPRLAKY---------DTSIIANIAGSSIEE 106

Query: 162 YNKAAWEELIDRVEQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATV 221
           Y   A        + T +DA+E+N SCP+    ++ G   G D  + ++V   +   +  
Sbjct: 107 YEFVA----ASFNQTTDVDALELNISCPN---VKEGGIQFGTDPFMAKKVTEVVKKASNK 159

Query: 222 PVWAKMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGY 281
           PV+ K++PN+ +I + A+    +G +G++ INT+   M I+L + +P       +  GG 
Sbjct: 160 PVYVKLSPNVHNIVEMAKAVEEAGADGLSMINTLTG-MKIHLPSRKPLIA----NKTGGL 214

Query: 282 SAKAVHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGV 341
           S  A+ P+A+  +  + + +       +  +  +GG+ +  D  E+++ GA+ V V T  
Sbjct: 215 SGPAIKPVAIRMIYEVRQQV-------SIPIIGMGGITSAEDVLEYLIAGADAVAVGTAN 267

Query: 342 MMHGYGLVKKLSLELKDFMKKHNFTSIED 370
             + +  V  ++ EL + ++++ F SIED
Sbjct: 268 FQNPFVCVDIIN-ELPEVLEQYGFNSIED 295


>PYRD_LISIN (Q92AH5) Dihydroorotate dehydrogenase (EC 1.3.3.1)
           (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD)
          Length = 304

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 89/327 (27%), Positives = 153/327 (46%), Gaps = 35/327 (10%)

Query: 49  LSVKVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDAAKVINVTPRYAR 108
           L+V++ GL + NP +  SG  G      K       G ++AK V+ +  ++ N TPR A 
Sbjct: 4   LAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEP-RLGNPTPRVAE 62

Query: 109 LRANANGSAKGEIIGWQNIELISDRPLETMLKEFKQLKEEYPDRIL--IASIMEEYNKAA 166
                  S     IG QN        LE +L       E++   I+  +A   E+     
Sbjct: 63  -----TASGMLNAIGLQN------PGLEHVLAHELPFLEQFETPIIANVAGATED----D 107

Query: 167 WEELIDRV-EQTGIDAIEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWA 225
           + ++  R+ E   + AIE+N SCP+    +  G A G D  +   +   + + A+VPV+ 
Sbjct: 108 YVQVCSRIGESKAVKAIELNISCPN---VKHGGIAFGTDPEVAHRLTKAVKSVASVPVYV 164

Query: 226 KMTPNITDISQPARVALSSGCEGVAAINTIMSVMGINLNTLRPEPCVEGYSTPGGYSAKA 285
           K++PN+ DI   A+   ++G +G+  INT++  M I+L T +P       +  GG S  A
Sbjct: 165 KLSPNVADIISIAQAIEAAGADGLTMINTLLG-MRIDLKTRKPVIA----NGTGGLSGPA 219

Query: 286 VHPIALGKVMSIAKMMKSEFDSENYSLSAIGGVETGGDAAEFILLGANTVQVCTGVMMHG 345
           + P+A+  +  +  +        N  +  +GGV+T  D  EF++ GA+ V V T      
Sbjct: 220 IKPVAIRMIHQVRAV-------SNIPIIGMGGVQTVDDVLEFLIAGADAVAVGTMNFTDP 272

Query: 346 YGLVKKLSLELKDFMKKHNFTSIEDFR 372
           + +  KL  EL   M +   +S+++ +
Sbjct: 273 F-ICPKLITELPKRMDELGISSLQELK 298


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.316    0.133    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,892,612
Number of Sequences: 164201
Number of extensions: 2034357
Number of successful extensions: 6380
Number of sequences better than 10.0: 108
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 6193
Number of HSP's gapped (non-prelim): 112
length of query: 424
length of database: 59,974,054
effective HSP length: 113
effective length of query: 311
effective length of database: 41,419,341
effective search space: 12881415051
effective search space used: 12881415051
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)