BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC139525.1 - phase: 0 
         (395 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

DSK1_SCHPO (P36616) Protein kinase dsk1 (EC 2.7.1.-) (Dis1-suppr...   309  9e-84
ST23_HUMAN (Q9UPE1) Serine/threonine-protein kinase 23 (EC 2.7.1...   299  9e-81
SPK1_CAEEL (Q03563) Serine/threonine-protein kinase spk-1 (EC 2....   296  6e-80
ST23_MOUSE (Q9Z0G2) Serine/threonine-protein kinase 23 (EC 2.7.1...   280  5e-75
KM65_YEAST (Q03656) Probable serine/threonine-protein kinase YMR...   185  2e-46
AFC2_ARATH (P51567) Protein kinase AFC2 (EC 2.7.1.-)                  113  7e-25
AFC1_ARATH (P51566) Protein kinase AFC1 (EC 2.7.1.-)                  110  6e-24
AFC3_ARATH (P51568) Protein kinase AFC3 (EC 2.7.1.-)                  107  5e-23
POM1_SCHPO (Q09690) Dual specificity protein kinase pom1 (EC 2.7...    98  4e-20
KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase C16...    96  2e-19
LKH1_SCHPO (Q10156) Protein kinase lkh1 (EC 2.7.1.37) (EC 2.7.1....    95  3e-19
DYR2_HUMAN (Q92630) Dual-specificity tyrosine-phosphorylation re...    95  3e-19
CLK2_HUMAN (P49760) Dual specificity protein kinase CLK2 (EC 2.7...    95  3e-19
MNB_DROME (P49657) Serine/threonine-protein kinase minibrain (EC...    94  6e-19
CLK2_MOUSE (O35491) Dual specificity protein kinase CLK2 (EC 2.7...    94  8e-19
PRP4_SCHPO (Q07538) Serine/threonine-protein kinase prp4 (EC 2.7...    92  2e-18
DYR3_HUMAN (O43781) Dual-specificity tyrosine-phosphorylation re...    90  9e-18
DYRB_MOUSE (Q9Z188) Dual-specificity tyrosine-phosphorylation re...    90  1e-17
DYRB_HUMAN (Q9Y463) Dual-specificity tyrosine-phosphorylation re...    90  1e-17
DYRA_RAT (Q63470) Dual-specificity tyrosine-phosphorylation regu...    89  1e-17

>DSK1_SCHPO (P36616) Protein kinase dsk1 (EC 2.7.1.-)
           (Dis1-suppressing protein kinase)
          Length = 544

 Score =  309 bits (791), Expect = 9e-84
 Identities = 168/383 (43%), Positives = 225/383 (57%), Gaps = 21/383 (5%)

Query: 17  SEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQK 76
           + +E  EDY  GGYH V IG+ F   RYVV+ KLGWGHFSTVWLA+D    R VALKV +
Sbjct: 54  THEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVR 113

Query: 77  SAQHYTEAALDEITILQQIAEGDTDD--KKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNL 134
           SA+HY E ++DEI ILQ+I EGD     KK ++ LLD+F H GPNG HVCMVFE LG+NL
Sbjct: 114 SAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENL 173

Query: 135 LTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLSTIDPSKDPR 194
           L+LI+   +RG+P+ +VK+I + +L+ LDYLH++  IIHTDLKPEN+L+    D  +   
Sbjct: 174 LSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHIE 233

Query: 195 KSGAPLILPNSKDKTMLESTAARDTKTSNGDFIKNHKKNIKRKAKQAAHGCAEKEASEGV 254
              AP    +    T    T      T+    IK   +++   A++       K  ++  
Sbjct: 234 ---APATTSSPTSNTSSSKTRNNTGYTAKAPIIK-RGQSVDNSAQE------RKTFAKNP 283

Query: 255 DGNHETSG-AVESSPNASSAREQASSSAGTSRLSDADGMKLKEQGNRRGSRTVRQKLLAS 313
             N + +G  + SSP  S+     S     S +S  D  K     N   S      +L  
Sbjct: 284 TKNSKPAGQVIPSSPFTSTLSRFPSLEGAVSEISLRDSQKHNSHPNSPFSSGDNSLILDG 343

Query: 314 AD--------VKCKLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACI 365
            +        +  K+ D GNACWT K FTND+QTRQYR PEVILG ++  SAD WSFACI
Sbjct: 344 VNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACI 403

Query: 366 CFELATGDVLFDPHSGDNFDRDE 388
            FEL TGD LFDP +G+++ +++
Sbjct: 404 IFELLTGDYLFDPRNGNSYSKED 426


>ST23_HUMAN (Q9UPE1) Serine/threonine-protein kinase 23 (EC
           2.7.1.37) (Muscle-specific serine kinase 1) (MSSK-1)
          Length = 533

 Score =  299 bits (765), Expect = 9e-81
 Identities = 177/397 (44%), Positives = 234/397 (58%), Gaps = 35/397 (8%)

Query: 18  EDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKS 77
           E E  +DY +GGYH V+IGD F+ GRY V  KLGWGHFSTVWL WD    R+VALKV KS
Sbjct: 54  EQEDPKDYCKGGYHPVKIGDVFN-GRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKS 112

Query: 78  AQHYTEAALDEITILQQIAEGDTDDKK--CVVKLLDHFKHSGPNGQHVCMVFEYLGDNLL 135
           A HYTE A+DEI +L+ + + D  D K   +V+L+D F+ SG NG HVCMV E LG  LL
Sbjct: 113 AGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLL 172

Query: 136 TLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLL-------STID 188
             I  S+Y+G+P+  VK I   +L GLDYLH +  IIHTD+KPENILL            
Sbjct: 173 KWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAA 232

Query: 189 PSKDPRKSGAPLILPNSKDKTMLESTAARDTKTSNGDFIKNHKKNIKRKAKQAAHGCAEK 248
            + + +++GAP   P S+    + STA ++  T  G   KN +K ++RK KQ      E+
Sbjct: 233 EATEWQQAGAP---PPSRS---IVSTAPQEVLT--GKLSKNKRKKMRRKRKQQKRLLEER 284

Query: 249 -------EASEGVDGNHET-------SGAVESSPNASSAREQASSS--AGTSRLSDADGM 292
                  EA E      ++       SG+  SS  + S    AS S  +G+S   +  G+
Sbjct: 285 LRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGFSGSLFSPASCSILSGSSNQRETGGL 344

Query: 293 KLKEQGNRRGSRTVRQKLLASAD-VKCKLVDFGNACWTYKQFTNDIQTRQYRCPEVILGS 351
                     +  V      +AD +K K+ D GNACW +K FT DIQTRQYR  EV++G+
Sbjct: 345 LSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGA 404

Query: 352 KYSTSADLWSFACICFELATGDVLFDPHSGDNFDRDE 388
           +Y   AD+WS AC+ FELATGD LF+PHSG+++ RDE
Sbjct: 405 EYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDE 441


>SPK1_CAEEL (Q03563) Serine/threonine-protein kinase spk-1 (EC
           2.7.1.37)
          Length = 1093

 Score =  296 bits (758), Expect = 6e-80
 Identities = 185/448 (41%), Positives = 238/448 (52%), Gaps = 68/448 (15%)

Query: 2   GGGHDDTTTESSD----FTSEDEGTED---YRRGGYHAVRIGDTFSSGRYVVQSKLGWGH 54
           GGGH D+  +  D      S+DE  ED   Y+RGGYH V IGD F++ RY V  KLGWGH
Sbjct: 471 GGGHSDSFQDPMDPGEQLGSDDEEQEDPRDYKRGGYHPVNIGDVFNA-RYHVIRKLGWGH 529

Query: 55  FSTVWLAWDSHHSRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKC--VVKLLDH 112
           FSTVWLAWD+   R+VA+K+ KSA+HYTEAALDEI +L  +   D +D  C  VV+LLD 
Sbjct: 530 FSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDE 589

Query: 113 FKHSGPNGQHVCMVFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSII 172
           F  +G NGQHV MVFE LG NLL LI  S+YRG+ +  V++IC  +L  L Y+H++  II
Sbjct: 590 FTVTGINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGII 649

Query: 173 HTDLKPENILLLSTIDPSKDPRKSGAPLILPNSKDKTMLESTAARD-TKTSNGDFIKNHK 231
           HTD+KPEN+L+  + +  K   +        N K      STA     K +  +  KN K
Sbjct: 650 HTDIKPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKK 709

Query: 232 KNIKRKAKQAAHGC-AEKEASEGVDGNHETSGAVESSPNASSAREQASSSAGTSRLSDAD 290
           K +K+KAK+      AE    EG+    + +G  E+  NA       +S      + D  
Sbjct: 710 KKMKKKAKKQREKLEAELAGLEGL--KMDANGLQEAYNNAPELENFNASQVEDVTMEDT- 766

Query: 291 GMKLKEQGNR---------RGSRTVRQKL---------LAS------------------- 313
              + E GNR         R  RT              LAS                   
Sbjct: 767 ---VNENGNRNKVEIRSPDRFDRTTLTPFSDPESKFGDLASPSAEYLSSPMSQLPPGGIL 823

Query: 314 -------------ADVKCKLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLW 360
                         D+  K+ D GNACW    +T+DIQTRQYR  EV++GS Y   AD+W
Sbjct: 824 PAPPVGPNIGDPYCDIDVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIW 883

Query: 361 SFACICFELATGDVLFDPHSGDNFDRDE 388
           S AC+ FELATGD LF+PH GDN+ RDE
Sbjct: 884 STACMAFELATGDYLFEPHQGDNYSRDE 911


>ST23_MOUSE (Q9Z0G2) Serine/threonine-protein kinase 23 (EC
           2.7.1.37) (Muscle-specific serine kinase 1) (MSSK-1)
          Length = 565

 Score =  280 bits (716), Expect = 5e-75
 Identities = 176/430 (40%), Positives = 231/430 (52%), Gaps = 68/430 (15%)

Query: 18  EDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKS 77
           E E  +DY +GGY+ V+IGD F+ GRY V  KLGWGHFSTVWL WD    R+VALKV KS
Sbjct: 53  EQEDPKDYCKGGYYPVKIGDLFN-GRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKS 111

Query: 78  AQHYTEAALDEITILQQIAEGDTDDKK--CVVKLLDHFKHSGPNGQHVCMVFEYLGDNLL 135
           A HYTE A+DEI +L+ + + D  D K   +V+L+D F+ SG NG HVCMV E LG  LL
Sbjct: 112 AGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLL 171

Query: 136 TLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLL-------STID 188
             I  S+Y+G+P+  VK I   +L GLDYLH +  IIHTD+KPENILL            
Sbjct: 172 KWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAA 231

Query: 189 PSKDPRKSGAPLILPNSKDKTMLESTAARDTKTSNGDFIKNHKKNIKRKAKQAAHGCAEK 248
            + + ++SGA    P S+      STA ++     G   KN +K ++RK KQ      E+
Sbjct: 232 EATEWQQSGAQ---PPSRSTV---STAPQEVLI--GKLSKNKRKKMRRKRKQQKRLLEER 283

Query: 249 -------EASEGV-------------DGNHETSGA-----------VESSPNASSAREQA 277
                  EA E                G+  +SG              SSP     R  +
Sbjct: 284 LRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLS 343

Query: 278 SSS------------------AGTSRLSDADGMKLKEQGNRRGSRTVRQKLLASAD-VKC 318
            SS                  +G+S   +  G+          +  V      +AD +K 
Sbjct: 344 PSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKI 403

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           K+ D GNACW +K FT DIQTRQYR  EV++G++Y   AD+WS AC+ FELATGD LF+P
Sbjct: 404 KIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEP 463

Query: 379 HSGDNFDRDE 388
           HSG+++ RDE
Sbjct: 464 HSGEDYSRDE 473


>KM65_YEAST (Q03656) Probable serine/threonine-protein kinase
           YMR216C (EC 2.7.1.37)
          Length = 742

 Score =  185 bits (470), Expect = 2e-46
 Identities = 90/182 (49%), Positives = 126/182 (68%), Gaps = 6/182 (3%)

Query: 7   DTTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHH 66
           D++  S D  +E E  +DYR GGYH    G+ +   RY++  KLGWGHFSTVWLA D  +
Sbjct: 122 DSSISSCDERNE-ESLKDYRPGGYHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVN 180

Query: 67  SRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKC-----VVKLLDHFKHSGPNGQ 121
           + +VA+K+ +  + YTEAA DEI +LQ++ + D   +       ++KLLDHF H GPNG 
Sbjct: 181 NTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGV 240

Query: 122 HVCMVFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENI 181
           HV MVFE LG+NLL LIK  ++RG+P+  VK+I   +L+GLDY+H++  IIHTD+KPEN+
Sbjct: 241 HVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENV 300

Query: 182 LL 183
           L+
Sbjct: 301 LM 302



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 55/182 (30%), Positives = 89/182 (48%), Gaps = 18/182 (9%)

Query: 220 KTSNGDFIKNHKKNIKR---KAKQAAHGCAEKEASEGVDGNHETSGAVESSPNASSAREQ 276
           K SN  F+ +   ++ R         +   +   ++  + N+  +   E   N     EQ
Sbjct: 440 KNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQ 499

Query: 277 ASSSAGTSRLSDADGMKLKEQGNRRG---SRTVRQKLLASADV-------KCKLVDFGNA 326
            + S  T  +S+     + +  +  G   S T+      S D+       + K+ D GNA
Sbjct: 500 LADSLSTFDISN-----ISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNA 554

Query: 327 CWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDPHSGDNFDR 386
           CW  + +TN IQTR+YR PEV+LG+ +   AD+WS AC+ FEL TGD LF+P  G ++ +
Sbjct: 555 CWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTK 614

Query: 387 DE 388
           D+
Sbjct: 615 DD 616



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 7/88 (7%)

Query: 193 PRKSGAPLILPNSKDKTMLESTAARDTKTSNGDFIKNHKKNIKRKAKQAAHGCAEKEASE 252
           P KS   L L  SK  +    T   DT +   DF     K+IK+K         E   S 
Sbjct: 55  PTKSKLSLALQTSKSSSSANGTVQEDTSSKTEDF---STKSIKKKPDSG----VESHVSI 107

Query: 253 GVDGNHETSGAVESSPNASSAREQASSS 280
             D   ++   ++S  + SS  E+   S
Sbjct: 108 QSDSGPQSDSDLDSDSSISSCDERNEES 135


>AFC2_ARATH (P51567) Protein kinase AFC2 (EC 2.7.1.-)
          Length = 427

 Score =  113 bits (283), Expect = 7e-25
 Identities = 65/174 (37%), Positives = 104/174 (59%), Gaps = 8/174 (4%)

Query: 27  RGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSAQHYTEAAL 86
           + G++   +GD  +  RY + SK+G G F  V   WD      VA+K+ +  + Y EAA+
Sbjct: 82  KDGHYIFELGDDLTP-RYKIYSKMGEGTFGQVLECWDRERKEMVAVKIVRGVKKYREAAM 140

Query: 87  DEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLIKYSDYRGM 146
            EI +LQQ+ + D    +C V++ + F +      H+C+VFE LG +L   ++ ++YR  
Sbjct: 141 IEIEMLQQLGKHDKGGNRC-VQIRNWFDYR----NHICIVFEKLGSSLYDFLRKNNYRSF 195

Query: 147 PINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLSTIDPSKDPRKSGAPL 200
           PI++V+EI + +L  + ++H  L +IHTDLKPENILL+S+ D  K P   G+ L
Sbjct: 196 PIDLVREIGWQLLECVAFMH-DLRMIHTDLKPENILLVSS-DYVKIPEYKGSRL 247



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 36/94 (38%), Positives = 50/94 (52%), Gaps = 1/94 (1%)

Query: 286 LSDADGMKLKEQGNRRGSRTVRQKLLASADVKCKLVDFGNACWTYKQFTNDIQTRQYRCP 345
           L  +D +K+ E    R  R V  K +  +    K++DFG+  +  +  T  + TR YR P
Sbjct: 231 LVSSDYVKIPEYKGSRLQRDVCYKRVPKSSA-IKVIDFGSTTYERQDQTYIVSTRHYRAP 289

Query: 346 EVILGSKYSTSADLWSFACICFELATGDVLFDPH 379
           EVILG  +S   D+WS  CI  EL TG+ LF  H
Sbjct: 290 EVILGLGWSYPCDVWSVGCIIVELCTGEALFQTH 323


>AFC1_ARATH (P51566) Protein kinase AFC1 (EC 2.7.1.-)
          Length = 467

 Score =  110 bits (275), Expect = 6e-24
 Identities = 61/160 (38%), Positives = 98/160 (61%), Gaps = 7/160 (4%)

Query: 27  RGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSAQHYTEAAL 86
           + G++   +GDT +  RY + SK+G G F  V   +D+ +   VA+KV +S   Y EAA+
Sbjct: 99  KDGHYVFVVGDTLTP-RYQILSKMGEGTFGQVLECFDNKNKEVVAIKVIRSINKYREAAM 157

Query: 87  DEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLIKYSDYRGM 146
            EI +LQ++   D    +C V++ + F +      H+C+VFE LG +L   ++ + YR  
Sbjct: 158 IEIDVLQRLTRHDVGGSRC-VQIRNWFDYR----NHICIVFEKLGPSLYDFLRKNSYRSF 212

Query: 147 PINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLST 186
           PI++V+E+   +L  + Y+H  L +IHTDLKPENILL+S+
Sbjct: 213 PIDLVRELGRQLLESVAYMH-DLRLIHTDLKPENILLVSS 251



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 27/61 (44%), Positives = 37/61 (60%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           KL+DFG+  + ++     + TR YR PEVILG  ++   DLWS  CI  EL +G+ LF  
Sbjct: 282 KLIDFGSTTFEHQDHNYIVSTRHYRAPEVILGVGWNYPCDLWSIGCILVELCSGEALFQT 341

Query: 379 H 379
           H
Sbjct: 342 H 342


>AFC3_ARATH (P51568) Protein kinase AFC3 (EC 2.7.1.-)
          Length = 400

 Score =  107 bits (267), Expect = 5e-23
 Identities = 58/163 (35%), Positives = 93/163 (56%), Gaps = 7/163 (4%)

Query: 24  DYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSAQHYTE 83
           D  R G++   + D  +  RY + SK+G G F  V   WD     YVA+K+ +S + Y +
Sbjct: 52  DDDRDGHYVFSLRDNLTP-RYKILSKMGEGTFGRVLECWDRDTKEYVAIKIIRSIKKYRD 110

Query: 84  AALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLIKYSDY 143
           AA+ EI +LQ++ + D    +CV       K+      H+C+VFE LG +L   +K + Y
Sbjct: 111 AAMIEIDVLQKLVKSDKGRTRCV-----QMKNWFDYRNHICIVFEKLGPSLFDFLKRNKY 165

Query: 144 RGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLST 186
              P+ +V++    +L  + Y+H +L ++HTDLKPENILL+S+
Sbjct: 166 SAFPLALVRDFGCQLLESVAYMH-ELQLVHTDLKPENILLVSS 207



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 39/100 (39%), Positives = 55/100 (55%), Gaps = 4/100 (4%)

Query: 286 LSDADGMKLKEQGNRRGSRTVRQKLLASADVKCKLVDFGNACWTYKQFTNDIQTRQYRCP 345
           L  ++ +KL +      + T  + L  S+ +K  L+DFG+     +   + +QTR YR P
Sbjct: 204 LVSSENVKLPDNKRSAANETHFRCLPKSSAIK--LIDFGSTVCDNRIHHSIVQTRHYRSP 261

Query: 346 EVILGSKYSTSADLWSFACICFELATGDVLFDPHSGDNFD 385
           EVILG  +S   DLWS  CI FEL TG+ LF  H  DN +
Sbjct: 262 EVILGLGWSYQCDLWSIGCILFELCTGEALFQTH--DNLE 299


>POM1_SCHPO (Q09690) Dual specificity protein kinase pom1 (EC
           2.7.1.37) (EC 2.7.1.112)
          Length = 1087

 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 67/177 (37%), Positives = 97/177 (53%), Gaps = 8/177 (4%)

Query: 7   DTTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHH 66
           D    + + TS + G +D  RG Y  V +GD  +  RY V   LG G F  V    D   
Sbjct: 665 DKRRSADENTSSNFGFDD-ERGDYKVV-LGDHIAY-RYEVVDFLGKGSFGQVLRCIDYET 721

Query: 67  SRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMV 126
            + VALK+ ++ + +   AL E  ILQ+I E D  D+ C+V+  DHF        H+C+ 
Sbjct: 722 GKLVALKIIRNKKRFHMQALVETKILQKIREWDPLDEYCMVQYTDHFYFR----DHLCVA 777

Query: 127 FEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILL 183
            E LG NL  LIK + ++G+PI ++K I   ++  L  L+++  +IH DLKPENILL
Sbjct: 778 TELLGKNLYELIKSNGFKGLPIVVIKSITRQLIQCLTLLNEK-HVIHCDLKPENILL 833



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 28/58 (48%), Positives = 37/58 (63%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLF 376
           K++DFG++C+  +     IQ+R YR PEVILG  Y T  D+WS  CI  E+ TG  LF
Sbjct: 842 KVIDFGSSCFEGECVYTYIQSRFYRSPEVILGMGYGTPIDVWSLGCIIAEMYTGFPLF 899


>KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase
           C16C9.07 (EC 2.7.1.37)
          Length = 836

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 62/165 (37%), Positives = 89/165 (53%), Gaps = 7/165 (4%)

Query: 19  DEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSA 78
           +E   D   G Y A++ GD     RY +   +G G F  V    D    + VA+KV K+ 
Sbjct: 495 NEALFDDDNGDYKAIQ-GDHLLY-RYEIIDTVGKGSFGQVLKCIDHKRGQVVAIKVIKNR 552

Query: 79  QHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLI 138
           Q +    L E+ IL+++ E D  DK  V++ L HF   G    H+C+V E LG NL  +I
Sbjct: 553 QKFHGQTLVEVGILKRLCEADPADKNNVIRYLSHFDFRG----HLCIVTELLGSNLFDVI 608

Query: 139 KYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILL 183
           + ++Y+G+P+ +VK      L  L  L  Q +IIH DLKPEN+LL
Sbjct: 609 RENNYKGLPLIVVKSFALQGLQALRLLQGQ-NIIHCDLKPENLLL 652



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 32/71 (45%), Positives = 45/71 (63%), Gaps = 2/71 (2%)

Query: 308 QKLLASADVKC--KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACI 365
           + LL S  +K   KL+DFG++C+  ++    +Q+R YR PE+ILG +Y    D+WSF CI
Sbjct: 648 ENLLLSHPLKARIKLIDFGSSCFYNEKVYTYLQSRFYRAPEIILGLEYGKEIDIWSFGCI 707

Query: 366 CFELATGDVLF 376
             EL TG  LF
Sbjct: 708 LAELFTGVPLF 718


>LKH1_SCHPO (Q10156) Protein kinase lkh1 (EC 2.7.1.37) (EC
           2.7.1.112)
          Length = 575

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 59/182 (32%), Positives = 99/182 (53%), Gaps = 17/182 (9%)

Query: 5   HDDTTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDS 64
           HD T  + S F  +D         G++ V     F++ RY V   LG G F  V   +D 
Sbjct: 218 HDTTAFDPSTFDDDD---------GHYKVVPNSKFAN-RYTVVRLLGHGTFGKVIQCYDQ 267

Query: 65  HHSRYVALKVQKSAQHYTEAALDEITILQQIAEGD-TDDKKCVVKLLDHFKHSGPNGQHV 123
              R+ A+KV ++   Y EA+L E+ +LQ IA  D T++ KC ++L D+F +     +H+
Sbjct: 268 STGRHCAIKVTRAIPKYREASLIELRVLQTIAHSDPTNENKC-IQLRDYFDYR----KHI 322

Query: 124 CMVFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILL 183
           C+V +  G ++   +K ++Y   P+  ++ +   +   + +LH  L ++HTDLKPEN+LL
Sbjct: 323 CIVTDLFGWSVFDFLKNNNYIPFPLKHIQMLSQQLFKSVAFLH-SLGLVHTDLKPENVLL 381

Query: 184 LS 185
           +S
Sbjct: 382 VS 383



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 35/84 (41%), Positives = 50/84 (58%), Gaps = 9/84 (10%)

Query: 303 SRTVR-------QKLLASADVKCKLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYST 355
           SRT+R       QK+L S +++  L+DFG+A +  +  ++ + TR YR PE+ILG  +S 
Sbjct: 386 SRTIRLPYRNYSQKVLNSCEIR--LIDFGSATFEDEYHSSVVSTRHYRAPEIILGLGWSY 443

Query: 356 SADLWSFACICFELATGDVLFDPH 379
             D+WS  CI  EL TG  LF  H
Sbjct: 444 PCDVWSIGCILVELFTGQALFQTH 467


>DYR2_HUMAN (Q92630) Dual-specificity tyrosine-phosphorylation
           regulated kinase 2 (EC 2.7.1.112) (EC 2.7.1.37)
          Length = 528

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 60/165 (36%), Positives = 91/165 (54%), Gaps = 7/165 (4%)

Query: 19  DEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSA 78
           + G  D  +G Y  V++     + RY V   +G G F  V  A+D    ++VALK+ ++ 
Sbjct: 126 NNGGYDDDQGSY--VQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNE 183

Query: 79  QHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLI 138
           + +   A +EI IL+ + + D D+   V+ +L++F        H+CM FE L  NL  LI
Sbjct: 184 KRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFR----NHICMTFELLSMNLYELI 239

Query: 139 KYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILL 183
           K + ++G  + +V++    IL  LD LHK   IIH DLKPENILL
Sbjct: 240 KKNKFQGFSLPLVRKFAHSILQCLDALHKN-RIIHCDLKPENILL 283



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 26/54 (48%), Positives = 38/54 (70%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATG 372
           K++DFG++C+ +++    IQ+R YR PEVILG++Y    D+WS  CI  EL TG
Sbjct: 292 KVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTG 345


>CLK2_HUMAN (P49760) Dual specificity protein kinase CLK2 (EC
           2.7.1.37) (EC 2.7.1.112) (CDC like kinase 2)
          Length = 499

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 66/207 (31%), Positives = 100/207 (47%), Gaps = 15/207 (7%)

Query: 29  GYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHS-RYVALKVQKSAQHYTEAALD 87
           G+    +GD     RY + S LG G F  V    D       VALK+ K+ + Y EAA  
Sbjct: 149 GHLIYHVGDWLQE-RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL 207

Query: 88  EITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLIKYSDYRGMP 147
           EI +L++I E D D+K   V++ D F + G    H+C+ FE LG +    +K ++Y   P
Sbjct: 208 EINVLEKINEKDPDNKNLCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYP 263

Query: 148 INMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLSTIDPSKDPRKSGAPLILPNSKD 207
           I+ V+ + F +   + +LH    + HTDLKPENIL +++               L   +D
Sbjct: 264 IHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNS--------DYELTYNLEKKRD 314

Query: 208 KTMLESTAARDTKTSNGDFIKNHKKNI 234
           +  ++STA R     +  F   H   I
Sbjct: 315 ERSVKSTAVRVVDFGSATFDHEHHSTI 341



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 26/61 (42%), Positives = 36/61 (58%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           ++VDFG+A + ++  +  + TR YR PEVIL   +S   D+WS  CI FE   G  LF  
Sbjct: 324 RVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQT 383

Query: 379 H 379
           H
Sbjct: 384 H 384


>MNB_DROME (P49657) Serine/threonine-protein kinase minibrain (EC
           2.7.1.37)
          Length = 843

 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 56/179 (31%), Positives = 98/179 (54%), Gaps = 8/179 (4%)

Query: 6   DDTTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSH 65
           DD ++   +    ++G +D      + ++ G+ F   RY + S +G G F  V  A+D  
Sbjct: 64  DDDSSNKKERKLYNDGYDDDNHD--YIIKNGEKFLD-RYEIDSLIGKGSFGQVVKAYDHE 120

Query: 66  HSRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCM 125
              +VA+K+ K+ + +   A  E+ +L+ +   D ++K  +VKL  HF        H+C+
Sbjct: 121 EQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWR----NHLCL 176

Query: 126 VFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLH-KQLSIIHTDLKPENILL 183
           VFE L  NL  L++ +++RG+ +N+ ++    +   L +L   +L+IIH DLKPENILL
Sbjct: 177 VFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILL 235



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 27/58 (46%), Positives = 40/58 (68%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLF 376
           K+VDFG++C   ++  + IQ+R YR PEV+LG +Y  + D+WS  CI  E+ TG+ LF
Sbjct: 244 KIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLF 301


>CLK2_MOUSE (O35491) Dual specificity protein kinase CLK2 (EC
           2.7.1.37) (EC 2.7.1.112) (CDC like kinase 2)
          Length = 499

 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 69/228 (30%), Positives = 107/228 (46%), Gaps = 15/228 (6%)

Query: 8   TTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHS 67
           T + SS  +S    + +    G+    +GD     RY + S LG G    V    D    
Sbjct: 127 TFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQE-RYEIVSTLGEGTSGRVVQCVDHRRG 185

Query: 68  -RYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMV 126
              VALK+ K+ + Y EAA  EI +L++I E D D+K   V++ D F + G    H+C+ 
Sbjct: 186 GTRVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHG----HMCIS 241

Query: 127 FEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILLLST 186
           FE LG +    +K ++Y   PI+ V+ + F +   + +LH    + HTDLKPENIL +++
Sbjct: 242 FELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNS 300

Query: 187 IDPSKDPRKSGAPLILPNSKDKTMLESTAARDTKTSNGDFIKNHKKNI 234
                          L   +D+  ++STA R     +  F   H   I
Sbjct: 301 --------DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTI 340



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 26/61 (42%), Positives = 36/61 (58%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           ++VDFG+A + ++  +  + TR YR PEVIL   +S   D+WS  CI FE   G  LF  
Sbjct: 323 RVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQT 382

Query: 379 H 379
           H
Sbjct: 383 H 383


>PRP4_SCHPO (Q07538) Serine/threonine-protein kinase prp4 (EC
           2.7.1.37)
          Length = 477

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 57/176 (32%), Positives = 99/176 (55%), Gaps = 9/176 (5%)

Query: 9   TTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSR 68
           +T +  F    +  +D    GY+ V + +   S RY+VQS LG G FSTV  A D + ++
Sbjct: 127 STLTRSFADMQDNWDDIE--GYYKVVLMEELDS-RYIVQSNLGKGMFSTVVSALDRNRNQ 183

Query: 69  YVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFE 128
             A+K+ ++ +   +  L E++IL+++   D + K+ ++    HF H      H+CMVFE
Sbjct: 184 TFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHK----NHLCMVFE 239

Query: 129 YLGDNLLTLI-KYSDYRGMPINMVKEICFHILVGLDYLHKQLSIIHTDLKPENILL 183
            L  NL  ++ K+    G+ I  V+   + + + LD L KQ ++IH+D+KP+N+L+
Sbjct: 240 MLSLNLRDILKKFGRNVGLSIKAVRLYAYQMFMALDLL-KQCNVIHSDIKPDNMLV 294



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 25/59 (42%), Positives = 34/59 (57%), Gaps = 1/59 (1%)

Query: 319 KLVDFGNAC-WTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLF 376
           K+ D G+A   +  + T  + +R YR PE+ILG  YS   D WS  C  +EL TG +LF
Sbjct: 302 KICDLGSASDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILF 360


>DYR3_HUMAN (O43781) Dual-specificity tyrosine-phosphorylation
           regulated kinase 3 (EC 2.7.1.-)
          Length = 588

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 54/141 (38%), Positives = 77/141 (54%), Gaps = 5/141 (3%)

Query: 43  RYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDD 102
           RY V   +G G F  V   +D    +YVALK+ ++ + +   A +EI IL+ + + D   
Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267

Query: 103 KKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGL 162
              V+ +L+ F        HVCM FE L  +L  LIK + ++G  + +V++    IL  L
Sbjct: 268 SMNVIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323

Query: 163 DYLHKQLSIIHTDLKPENILL 183
           D LHK   IIH DLKPENILL
Sbjct: 324 DALHKN-KIIHCDLKPENILL 343



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 32/58 (55%), Positives = 43/58 (73%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLF 376
           K++DFG++C+ Y++    IQ+R YR PE+ILGS+YST  D+WSF CI  EL TG  LF
Sbjct: 352 KVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFRCILAELLTGQPLF 409


>DYRB_MOUSE (Q9Z188) Dual-specificity tyrosine-phosphorylation
           regulated kinase 1B (EC 2.7.1.37) (EC 2.7.1.112)
          Length = 589

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/166 (34%), Positives = 90/166 (53%), Gaps = 12/166 (7%)

Query: 19  DEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSA 78
           D+   DY       VR G+ +   RY + S +G G F  V  A+D      VA+K+ K+ 
Sbjct: 93  DDDNHDY------IVRSGERWLE-RYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNK 145

Query: 79  QHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLI 138
           + +   A  E+ +L+ + + DT+ K  +V L  HF        H+C+VFE L  NL  L+
Sbjct: 146 KAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLL 201

Query: 139 KYSDYRGMPINMVKEICFHILVGLDYL-HKQLSIIHTDLKPENILL 183
           + + +RG+ +N+ +++   +   L +L   +LSIIH DLKPENILL
Sbjct: 202 RNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILL 247



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 30/65 (46%), Positives = 42/65 (64%), Gaps = 3/65 (4%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           K+VDFG++C   ++    IQ+R YR PEV+LG+ Y  + D+WS  CI  E+ TG+ LF  
Sbjct: 256 KIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLF-- 313

Query: 379 HSGDN 383
            SG N
Sbjct: 314 -SGSN 317


>DYRB_HUMAN (Q9Y463) Dual-specificity tyrosine-phosphorylation
           regulated kinase 1B (EC 2.7.1.37) (EC 2.7.1.112) (Mirk
           protein kinase) (Minibrain-related kinase)
          Length = 629

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/166 (34%), Positives = 90/166 (53%), Gaps = 12/166 (7%)

Query: 19  DEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWDSHHSRYVALKVQKSA 78
           D+   DY       VR G+ +   RY + S +G G F  V  A+D      VA+K+ K+ 
Sbjct: 93  DDDNHDY------IVRSGERWLE-RYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNK 145

Query: 79  QHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHVCMVFEYLGDNLLTLI 138
           + +   A  E+ +L+ + + DT+ K  +V L  HF        H+C+VFE L  NL  L+
Sbjct: 146 KAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLL 201

Query: 139 KYSDYRGMPINMVKEICFHILVGLDYL-HKQLSIIHTDLKPENILL 183
           + + +RG+ +N+ +++   +   L +L   +LSIIH DLKPENILL
Sbjct: 202 RNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILL 247



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 30/65 (46%), Positives = 42/65 (64%), Gaps = 3/65 (4%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLFDP 378
           K+VDFG++C   ++    IQ+R YR PEV+LG+ Y  + D+WS  CI  E+ TG+ LF  
Sbjct: 256 KIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLF-- 313

Query: 379 HSGDN 383
            SG N
Sbjct: 314 -SGSN 317


>DYRA_RAT (Q63470) Dual-specificity tyrosine-phosphorylation
           regulated kinase 1A (EC 2.7.1.-) (Protein kinase
           minibrain homolog) (MNBH) (RP86) (Dual specificity
           YAK1-related kinase)
          Length = 763

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 57/181 (31%), Positives = 98/181 (53%), Gaps = 8/181 (4%)

Query: 4   GHDDTTTESSDFTSEDEGTEDYRRGGYHAVRIGDTFSSGRYVVQSKLGWGHFSTVWLAWD 63
           G  D ++   +    ++G +D      + V+ G+ +   RY + S +G G F  V  A+D
Sbjct: 122 GQGDDSSHKKERKVYNDGYDDDNYD--YIVKNGEKWMD-RYEIDSLIGKGSFGQVVKAYD 178

Query: 64  SHHSRYVALKVQKSAQHYTEAALDEITILQQIAEGDTDDKKCVVKLLDHFKHSGPNGQHV 123
                +VA+K+ K+ + +   A  E+ +L+ + + DT+ K  +V L  HF        H+
Sbjct: 179 RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR----NHL 234

Query: 124 CMVFEYLGDNLLTLIKYSDYRGMPINMVKEICFHILVGLDYL-HKQLSIIHTDLKPENIL 182
           C+VFE L  NL  L++ +++RG+ +N+ ++    +   L +L   +LSIIH DLKPENIL
Sbjct: 235 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 294

Query: 183 L 183
           L
Sbjct: 295 L 295



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 27/58 (46%), Positives = 38/58 (64%)

Query: 319 KLVDFGNACWTYKQFTNDIQTRQYRCPEVILGSKYSTSADLWSFACICFELATGDVLF 376
           K+VDFG++C   ++    IQ+R YR PEV+LG  Y  + D+WS  CI  E+ TG+ LF
Sbjct: 304 KIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLF 361


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.316    0.133    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,180,146
Number of Sequences: 164201
Number of extensions: 2038111
Number of successful extensions: 9339
Number of sequences better than 10.0: 1367
Number of HSP's better than 10.0 without gapping: 534
Number of HSP's successfully gapped in prelim test: 834
Number of HSP's that attempted gapping in prelim test: 7072
Number of HSP's gapped (non-prelim): 2473
length of query: 395
length of database: 59,974,054
effective HSP length: 112
effective length of query: 283
effective length of database: 41,583,542
effective search space: 11768142386
effective search space used: 11768142386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)