BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC137986.3 + phase: 0 
         (571 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CTR1_MOUSE (Q09143) High-affinity cationic amino acid transporte...   340  6e-93
CTR1_RAT (P30823) High-affinity cationic amino acid transporter-...   337  6e-92
CTR1_HUMAN (P30825) High-affinity cationic amino acid transporte...   332  2e-90
CTR3_HUMAN (Q8WY07) Cationic amino acid transporter 3 (CAT-3) (S...   309  1e-83
CTR3_MOUSE (P70423) Cationic amino acid transporter 3 (CAT-3) (S...   307  6e-83
CTR3_RAT (O08812) Cationic amino acid transporter 3 (CAT-3) (Sol...   306  9e-83
CTR2_HUMAN (P52569) Low-affinity cationic amino acid transporter...   305  2e-82
CTR2_MOUSE (P18581) Low-affinity cationic amino acid transporter...   298  2e-80
CTR4_HUMAN (O43246) Cationic amino acid transporter-4 (CAT-4) (C...   265  3e-70
YK22_MYCBO (P63350) Hypothetical transport protein Mb2022c            142  2e-33
YJ99_MYCTU (P63349) Hypothetical transport protein Rv1999c/MT2055     142  2e-33
YLA1_HUMAN (Q9UM01) Y+L amino acid transporter 1 (y(+)L-type ami...   122  3e-27
BAT1_HUMAN (P82251) B(0,+)-type amino acid transporter 1 (B(0,+)...   110  1e-23
BAT1_RAT (P82252) B(0,+)-type amino acid transporter 1 (B(0,+)AT...   106  1e-22
LAT1_HUMAN (Q01650) Large neutral amino acids transporter small ...   106  2e-22
FRLA_ECOLI (P45539) Putative fructoselysine transporter frlA          106  2e-22
FRLA_ECO57 (Q8X845) Putative fructoselysine transporter frlA          105  2e-22
ROCC_BACSU (P39636) Amino-acid permease rocC                          105  3e-22
MMUP_ECOLI (Q47689) Probable S-methylmethionine permease              104  7e-22
GABP_BACSU (P46349) GABA permease (4-amino butyrate transport ca...   103  1e-21

>CTR1_MOUSE (Q09143) High-affinity cationic amino acid transporter-1
           (CAT-1) (CAT1) (System Y+ basic amino acid transporter)
           (Ecotropic retroviral leukemia receptor) (ERR)
           (Ecotropic retrovirus receptor)
          Length = 622

 Score =  340 bits (872), Expect = 6e-93
 Identities = 189/424 (44%), Positives = 264/424 (61%), Gaps = 26/424 (6%)

Query: 17  RRKQVDSPRQNTKPLLAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLI 76
           RRK VD  R+ ++  L++ L+ Y L+A+GVGST+GAGVYVL G VARE++GPA+ ISFLI
Sbjct: 15  RRKVVDCSREESR--LSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLI 72

Query: 77  AGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGI 136
           A LA+ L+  CY E   R P  GSAY YSY+ +GE  A++ GW L+L Y IG+++VAR  
Sbjct: 73  AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAW 132

Query: 137 TPNLAPLFGGLDNLPFFLSRQHI----PGIDIVV-DPCAAILVLLVTGLLCLGIKESTVV 191
           +     L G         SRQH+    PG+     D  A I+++++TGLL LG+KES +V
Sbjct: 133 SATFDELIGKPIGE---FSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMV 189

Query: 192 QGIVTSVNVCALLFVIVAGGYMGFKSGWVGYEL--------------PTGYFPFGVDGML 237
             I T +NV  L F++V+G   G    W   E                 G+ PFG  G+L
Sbjct: 190 NKIFTCINVLVLCFIVVSGFVKGSIKNWQLTEKNFSCNNNDTNVKYGEGGFMPFGFSGVL 249

Query: 238 AGSATVFFAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYA 297
           +G+AT F+A+VGFD +A+T EEVKNPQ+ +P+GI ASL +C   Y  VS  +  ++PY+ 
Sbjct: 250 SGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFC 309

Query: 298 IDPDTPISSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFC 357
           +D D+P+  AF   G + A Y +  G+  AL ++L+G + P PR++ AMA DGLL  F  
Sbjct: 310 LDIDSPLPGAFKHQGWEEAKYAVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLA 369

Query: 358 DINKHTLVPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIP-- 415
            IN  T  PV  T+ +G  AAV+AF  E+ DL  ++S+GTLLA+++VA  VL+LRY P  
Sbjct: 370 KINNRTKTPVIATVTSGAIAAVMAFLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQ 429

Query: 416 PNKV 419
           PN V
Sbjct: 430 PNLV 433


>CTR1_RAT (P30823) High-affinity cationic amino acid transporter-1
           (CAT-1) (CAT1) (System Y+ basic amino acid transporter)
           (Ecotropic retroviral leukemia receptor) (ERR)
           (Ecotropic retrovirus receptor)
          Length = 624

 Score =  337 bits (863), Expect = 6e-92
 Identities = 191/452 (42%), Positives = 273/452 (60%), Gaps = 31/452 (6%)

Query: 17  RRKQVDSPRQNTKPLLAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLI 76
           RRK VD  R+ ++  L++ L+ Y L+A+GVGST+GAGVYVL G VARE++GPA+ ISFLI
Sbjct: 15  RRKVVDCSREESR--LSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLI 72

Query: 77  AGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGI 136
           A LA+ L+  CY E   R P  GSAY YSY+ +GE  A++ GW L+L Y IG+++VAR  
Sbjct: 73  AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAW 132

Query: 137 TPNLAPLFGGLDNLPFFLSRQHI----PGIDIVV-DPCAAILVLLVTGLLCLGIKESTVV 191
           +     L G         SRQH+    PG+     D  A I+++++TGLL LG+KES +V
Sbjct: 133 SATFDELIGKPIGE---FSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMV 189

Query: 192 QGIVTSVNVCALLFVIVAGGYMGFKSGWVGYELPT----------------GYFPFGVDG 235
             I T +NV  L F++V+G   G    W   E  +                G+ PFG  G
Sbjct: 190 NKIFTCINVLVLCFIMVSGFVKGSIENWQLTENKSSPLCGNNDTNVKYGEGGFMPFGFSG 249

Query: 236 MLAGSATVFFAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPY 295
           +L+G+AT F+A+VGFD +A+T EEVKNPQ+ +P+GI ASL +C   Y  VS  +  ++PY
Sbjct: 250 VLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPY 309

Query: 296 YAIDPDTPISSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPF 355
           + +D D+P+  AF   G + A Y +  G+  AL ++ +G + P PR++ AMA DGLL  F
Sbjct: 310 FCLDTDSPLPGAFKYRGWEEAKYAVAVGSLCALSTSPLGSMFPMPRVIYAMAEDGLLFKF 369

Query: 356 FCDINKHTLVPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIP 415
              IN  T  P+  T+ +G  AAV+AF  E+ DL  ++S+GTLLA+++VA  VL+LRY P
Sbjct: 370 LAKINDRTKTPIIATVTSGAIAAVMAFLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQP 429

Query: 416 --PNKVPVPPSLQDSIVEIKVEYEEENIGTSE 445
             PN V       D + ++    + E +  SE
Sbjct: 430 EQPNLVYQMARTTDELDQVD---QNEMVSASE 458


>CTR1_HUMAN (P30825) High-affinity cationic amino acid transporter-1
           (CAT-1) (CAT1) (System Y+ basic amino acid transporter)
           (Ecotropic retroviral leukemia receptor homolog) (ERR)
           (Ecotropic retrovirus receptor homolog)
          Length = 629

 Score =  332 bits (851), Expect = 2e-90
 Identities = 187/442 (42%), Positives = 269/442 (60%), Gaps = 35/442 (7%)

Query: 17  RRKQVDSPRQNTKPLLAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLI 76
           RRK VD  R+ T+  L++ L+ + L+A+GVGST+GAGVYVL G VARE++GPA+ ISFLI
Sbjct: 15  RRKVVDCSREETR--LSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLI 72

Query: 77  AGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGI 136
           A LA+ L+  CY E   R P  GSAY YSY+ +GE  A++ GW L+L Y IG+++VAR  
Sbjct: 73  AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAW 132

Query: 137 TPNLAPLFGGLDNLPFFLSRQHI----PGIDIVVDP--CAAILVLLVTGLLCLGIKESTV 190
           +     L G         SR H+    PG+ +  +P   A I++L++TGLL LG+KES +
Sbjct: 133 SATFDELIGRPIGE---FSRTHMTLNAPGV-LAENPDIFAVIIILILTGLLTLGVKESAM 188

Query: 191 VQGIVTSVNVCALLFVIVAGGYMGFKSGWV---------------------GYELPTGYF 229
           V  I T +NV  L F++V+G   G    W                      G     G+ 
Sbjct: 189 VNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFM 248

Query: 230 PFGVDGMLAGSATVFFAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVV 289
           PFG  G+L+G+AT F+A+VGFD +A+T EEVKNPQ+ +P+GI ASL +C   Y  VS  +
Sbjct: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308

Query: 290 VGLVPYYAIDPDTPISSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARD 349
             ++PY+ +D ++P+  AF   G + A Y +  G+  AL ++L+G + P PR++ AMA D
Sbjct: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368

Query: 350 GLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVL 409
           GLL  F  ++N  T  P+  T+ +G  AAV+AF  ++ DL  ++S+GTLLA+++VA  VL
Sbjct: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428

Query: 410 ILRYIP--PNKVPVPPSLQDSI 429
           +LRY P  PN V    S  D +
Sbjct: 429 VLRYQPEQPNLVYQMASTSDEL 450


>CTR3_HUMAN (Q8WY07) Cationic amino acid transporter 3 (CAT-3)
           (Solute carrier family 7 member 3) (Cationic amino acid
           transporter y+)
          Length = 619

 Score =  309 bits (792), Expect = 1e-83
 Identities = 181/448 (40%), Positives = 266/448 (58%), Gaps = 32/448 (7%)

Query: 17  RRKQVDSPRQNTKPLLAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLI 76
           RR+ ++S    T+  LA+ LS   L+A+GVGST+GAGVYVL G VA++ +GP++ I FL+
Sbjct: 15  RRRTLESGMAETR--LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLV 72

Query: 77  AGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGI 136
           A L++ L+  CYAE   R P +GSAY YSY+ +GE  A+  GW L+L Y IG+A+VAR  
Sbjct: 73  AALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAW 132

Query: 137 TPNLAPLFGGLDNLPFFLS-RQHIPGIDIVVDPCAAI-LVLLVTGLLCLGIKESTVVQGI 194
           +     L G   +     S   H+P +        A+ LVLL+TGLL LG  ES +V  +
Sbjct: 133 SSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKV 192

Query: 195 VTSVNVCALLFVIVAGGYMGFKSGWV----GYELPT---------------GYFPFGVDG 235
            T VN+  L FV+++G   G    W      YEL                 G+ PFG +G
Sbjct: 193 FTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEG 252

Query: 236 MLAGSATVFFAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPY 295
           +L G+AT F+A+VGFD +A+T EE +NPQR +P+GI  SL +C   Y  VS  +  ++PY
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPY 312

Query: 296 YAIDPDTPISSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPF 355
           Y + P++P+  AF   G   A Y++  G+  AL ++L+G + P PR++ AMA DGLL   
Sbjct: 313 YQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRV 372

Query: 356 FCDINKHTLVPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIP 415
              I+  T  P+  T+++G+ AA +AF  +++DL  ++S+GTLLA+++V+I VLILRY P
Sbjct: 373 LARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQP 432

Query: 416 PNKVPVPPSLQDSIVEIKVEYEEENIGT 443
                     Q++    +VE +EE I T
Sbjct: 433 D---------QETKTGEEVELQEEAITT 451


>CTR3_MOUSE (P70423) Cationic amino acid transporter 3 (CAT-3)
           (Solute carrier family 7 member 3) (Cationic amino acid
           transporter y+)
          Length = 618

 Score =  307 bits (786), Expect = 6e-83
 Identities = 173/439 (39%), Positives = 263/439 (59%), Gaps = 33/439 (7%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           LA+ LS   L+A+GVGST+GAGVYVL G VA++ +GP++ I FL+A L++ L+  CYAE 
Sbjct: 28  LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEF 87

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
             R P +GSAY YSY+ +GE  A+  GW L+L Y IG+A+VAR  +     L G   +  
Sbjct: 88  GARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISRT 147

Query: 152 F----FLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVI 207
                 L   H+  +    D  A  LVLL+TGLL LG  +S +V  + T +N+  L FVI
Sbjct: 148 LKGTILLKMPHV--LAEYPDFFALALVLLLTGLLVLGASKSALVTKVFTGMNLLVLSFVI 205

Query: 208 VAGGYMGFKSGWV----GYELPT---------------GYFPFGVDGMLAGSATVFFAYV 248
           ++G   G    W      Y L                 G+ PFG++G+L G+AT F+A+V
Sbjct: 206 ISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFYAFV 265

Query: 249 GFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISSAF 308
           GFD +A+T EE +NPQR +P+GI  S+F+C   Y  VS  +  ++PYY + P++P+  AF
Sbjct: 266 GFDCIATTGEEAQNPQRSIPMGIVISMFICFLAYFGVSSALTLMMPYYKLHPESPLPEAF 325

Query: 309 SDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVK 368
           S  G + A Y++  G+  AL ++L+G + P PR++ +MA DGLL      ++  T +P+ 
Sbjct: 326 SYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVMYSMAEDGLLFRVLAKVHSVTHIPIV 385

Query: 369 GTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIPPNKVPVPPSLQDS 428
            T+++G+ AA +AF  E++DL  ++S+GTLLA ++V+I VLILRY P  ++         
Sbjct: 386 ATLVSGVIAAFMAFLFELTDLVDLMSIGTLLAHSLVSICVLILRYQPDQEM--------K 437

Query: 429 IVEIKVEYEEENIGTSEVS 447
            VE ++E +EE +   +++
Sbjct: 438 SVEEEMELQEETLEAEKLT 456


>CTR3_RAT (O08812) Cationic amino acid transporter 3 (CAT-3) (Solute
           carrier family 7 member 3) (Cationic amino acid
           transporter y+)
          Length = 619

 Score =  306 bits (784), Expect = 9e-83
 Identities = 172/417 (41%), Positives = 251/417 (59%), Gaps = 37/417 (8%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           LA+ LS   L+A+GVGST+GAGVYVL G VA+E +GP++ I FL+A L++ L+  CYAE 
Sbjct: 28  LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKEKAGPSIVICFLVAALSSVLAGLCYAEF 87

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGG----- 146
             R P +GSAY YSY+ +GE  A+  GW L+L Y IG+A+VAR  +     L G      
Sbjct: 88  GARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISQT 147

Query: 147 -----LDNLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVC 201
                L N+P  L+           D  A  LVLL+TGLL LG  ES +V  + T +N+ 
Sbjct: 148 LKGTILLNMPHVLAEYP--------DFFALALVLLLTGLLVLGANESGLVTKVFTGMNLL 199

Query: 202 ALLFVIVAGGYMGFKSGWV----GYELPT---------------GYFPFGVDGMLAGSAT 242
            L FVI++G   G    W      Y L                 G+ PFG++G+L G+AT
Sbjct: 200 VLGFVIISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAAT 259

Query: 243 VFFAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDT 302
            F+A+VGFD +A+T EE +NPQR +P+GI  SL +C   Y  VS  +  ++PYY + P++
Sbjct: 260 CFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSICFLAYFGVSSALTLMMPYYKLQPES 319

Query: 303 PISSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKH 362
           P+  AF+  G + A Y++  G+  AL ++L+G + P PR++ AMA DGLL      ++  
Sbjct: 320 PLPEAFTYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARVHNG 379

Query: 363 TLVPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIPPNKV 419
           T  P+  T+++G+ AA +AF  E++DL  ++S+GTLLA+++V+I VLILRY P  ++
Sbjct: 380 THTPIVATVVSGVIAAFMAFLFELTDLVDLMSIGTLLAYSLVSICVLILRYQPDQEM 436


>CTR2_HUMAN (P52569) Low-affinity cationic amino acid transporter-2
           (CAT-2) (CAT2)
          Length = 658

 Score =  305 bits (781), Expect = 2e-82
 Identities = 173/409 (42%), Positives = 243/409 (59%), Gaps = 27/409 (6%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + LS   LIA+GVGST+GAGVYVL G VA+  SGP++ +SFLIA LA+ ++  CYAE 
Sbjct: 30  LCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEF 89

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
             R P  GSAY Y+Y+ +GE  A++ GW L+L Y IG+++VAR  +     L      + 
Sbjct: 90  GARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAGSGTFDELLS--KQIG 147

Query: 152 FFLS---RQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIV 208
            FL    R +  G+    D  A  L+LL+ GLL  G+KES  V  + T+VN+  LLFV+V
Sbjct: 148 QFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMV 207

Query: 209 AGGYMGFKSGWV------------GYELPT----------GYFPFGVDGMLAGSATVFFA 246
           AG   G  + W               E P+          G+ P+G  G LAG+AT F+A
Sbjct: 208 AGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYA 267

Query: 247 YVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISS 306
           +VGFD +A+T EEV+NPQ+ +P+GI  SL +C   Y  VS  +  ++PYY +D  +P+  
Sbjct: 268 FVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPV 327

Query: 307 AFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVP 366
           AF   G   A Y++ AG+  AL ++L+G I P PR+  AMA DGLL      IN  T  P
Sbjct: 328 AFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVNYAMAEDGLLFKCLAQINSKTKTP 387

Query: 367 VKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIP 415
           +  T+ +G  AA++AF  ++  L  M+S+GTL+A+++VA  VLILRY P
Sbjct: 388 IIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQP 436


>CTR2_MOUSE (P18581) Low-affinity cationic amino acid transporter-2
           (CAT-2) (CAT2) (TEA protein) (T-cell early activation
           protein) (20.5)
          Length = 657

 Score =  298 bits (764), Expect = 2e-80
 Identities = 172/408 (42%), Positives = 244/408 (59%), Gaps = 26/408 (6%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + L+   LIA+GVGST+GAGVYVL G VA+  SGP++ +SFLIA LA+ ++  CYAE 
Sbjct: 30  LCRCLTTVDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEF 89

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
             R P  GSAY Y+Y+ +GE  A++ GW L+L Y IG+++VAR  +     L        
Sbjct: 90  GARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIG-Q 148

Query: 152 FFLS--RQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIVA 209
           FF +  + +  G+    D  A  LVLL+ GLL  G+KES  V    T++N+  LLFV+VA
Sbjct: 149 FFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVA 208

Query: 210 GGYMGFKSGW------------VGYELPT----------GYFPFGVDGMLAGSATVFFAY 247
           G   G  + W               E P+          G+ P+G  G LAG+AT F+A+
Sbjct: 209 GFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAF 268

Query: 248 VGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISSA 307
           VGFD +A+T EEV+NPQ+ +P+GI  SL +C   Y  VS  +  ++PYY +D  +P+  A
Sbjct: 269 VGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVA 328

Query: 308 FSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPV 367
           F       A Y++ AG+  AL ++L+G + P PRIL AMARDGLL  F   ++K    PV
Sbjct: 329 FEYVRWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQ-SPV 387

Query: 368 KGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYIP 415
             T+  G+ +AV+AF  ++  L  M+S+GTL+A+++VA  VLILRY P
Sbjct: 388 AATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQP 435


>CTR4_HUMAN (O43246) Cationic amino acid transporter-4 (CAT-4)
           (CAT4)
          Length = 636

 Score =  265 bits (676), Expect = 3e-70
 Identities = 153/403 (37%), Positives = 236/403 (57%), Gaps = 17/403 (4%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + LS   L  +GVG  +G+G+YVL G VA+E +GPA+ +SF +A +A+ L+A CYAE 
Sbjct: 33  LRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEF 92

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGG----- 146
             R P  GSAY ++Y+ +GE  A+LIGW +LLEY IG AAVAR  +  L  +F       
Sbjct: 93  GARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNF 152

Query: 147 LDNLPFFLSRQH---IPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCAL 203
            ++   FL+      +PG+          L L      C      T      +++++  +
Sbjct: 153 TEDPRGFLAGAPPGPLPGLPGCWHHPPWPLPLSPVEPACPPWLNHTF-----SAISLLVI 207

Query: 204 LFVIVAGGYMGFKSGWVGYELPTGYFPFGVDGMLAGSATVFFAYVGFDAVASTAEEVKNP 263
           LF+++ G  +     W   E   G+ PFG  G++AG+A+ F+A+VGFD +A+++EE +NP
Sbjct: 208 LFIVILGFILAQPHNWSADE--GGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNP 265

Query: 264 QRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISSAFSDHGMQWAAYIINAG 323
           +R +PL I  SL +  G Y+LVS V+  +VP++++DPD+ ++ AF   G +WA +I+ AG
Sbjct: 266 RRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAG 325

Query: 324 ACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFS 383
           +  A+ + L+  +   PRI+ AMA DGL    F  ++  T VPV GT+  GL  A LA  
Sbjct: 326 SICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALL 385

Query: 384 MEVSDLAGMVSVGTLLAFTMVAISVLILRY--IPPNKVPVPPS 424
           +++  L   +S+GTLLA+T VA S+++LR+    P   P P S
Sbjct: 386 LDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPAS 428


>YK22_MYCBO (P63350) Hypothetical transport protein Mb2022c
          Length = 440

 Score =  142 bits (358), Expect = 2e-33
 Identities = 105/385 (27%), Positives = 177/385 (45%), Gaps = 35/385 (9%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + L +   + IG+GS IGAG++  +   A   +G  L +   +A + A  +A   A L
Sbjct: 14  LRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYA-AGSGLLLGLAVAAVVAYCNAISSARL 72

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
           A R P++G  Y Y  + LG+   +L GW  ++  T   AA+A  +   + P         
Sbjct: 73  AARYPASGGTYVYGRMRLGDFWGYLAGWGFVVGKTASCAAMALTVGFYVWP--------- 123

Query: 152 FFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIVAGG 211
              ++ H   + +VV          +T +   GI++S  +   + +V +  L  V+VA  
Sbjct: 124 ---AQAHAVAVAVVV---------ALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAA- 170

Query: 212 YMGFKSGWVGYELPTGYFPFGVD----GMLAGSATVFFAYVGFDAVASTAEEVKNPQRDL 267
              + SG             GVD    GML  +  +FFA+ G+  +A+  EEV++P R +
Sbjct: 171 ---YGSG----AADPARLDIGVDAHVWGMLQAAGLLFFAFAGYARIATLGEEVRDPARTI 223

Query: 268 PLGIGASLFLCCGMYMLVSVVVVGLV-PYYAIDPDTPISSAFSDHGMQWAAYIINAGACT 326
           P  I  +L +   +Y LV+V V+ ++ P        P+S A    G+ W   ++  GA  
Sbjct: 224 PRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAPLSEAMRVAGVNWLIPVVQIGAAV 283

Query: 327 ALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFSMEV 386
           A + +L+  IL   R  +AMARD  LP +   ++    VP +  ++ G   A LA + ++
Sbjct: 284 AALGSLLALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAATADI 343

Query: 387 SDLAGMVSVGTLLAFTMVAISVLIL 411
               G  S G L+ + +   S L L
Sbjct: 344 RGAIGFSSFGVLVYYAIANASALTL 368


>YJ99_MYCTU (P63349) Hypothetical transport protein Rv1999c/MT2055
          Length = 440

 Score =  142 bits (358), Expect = 2e-33
 Identities = 105/385 (27%), Positives = 177/385 (45%), Gaps = 35/385 (9%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + L +   + IG+GS IGAG++  +   A   +G  L +   +A + A  +A   A L
Sbjct: 14  LRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYA-AGSGLLLGLAVAAVVAYCNAISSARL 72

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
           A R P++G  Y Y  + LG+   +L GW  ++  T   AA+A  +   + P         
Sbjct: 73  AARYPASGGTYVYGRMRLGDFWGYLAGWGFVVGKTASCAAMALTVGFYVWP--------- 123

Query: 152 FFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIVAGG 211
              ++ H   + +VV          +T +   GI++S  +   + +V +  L  V+VA  
Sbjct: 124 ---AQAHAVAVAVVV---------ALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAA- 170

Query: 212 YMGFKSGWVGYELPTGYFPFGVD----GMLAGSATVFFAYVGFDAVASTAEEVKNPQRDL 267
              + SG             GVD    GML  +  +FFA+ G+  +A+  EEV++P R +
Sbjct: 171 ---YGSG----AADPARLDIGVDAHVWGMLQAAGLLFFAFAGYARIATLGEEVRDPARTI 223

Query: 268 PLGIGASLFLCCGMYMLVSVVVVGLV-PYYAIDPDTPISSAFSDHGMQWAAYIINAGACT 326
           P  I  +L +   +Y LV+V V+ ++ P        P+S A    G+ W   ++  GA  
Sbjct: 224 PRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAPLSEAMRVAGVNWLIPVVQIGAAV 283

Query: 327 ALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFSMEV 386
           A + +L+  IL   R  +AMARD  LP +   ++    VP +  ++ G   A LA + ++
Sbjct: 284 AALGSLLALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAATADI 343

Query: 387 SDLAGMVSVGTLLAFTMVAISVLIL 411
               G  S G L+ + +   S L L
Sbjct: 344 RGAIGFSSFGVLVYYAIANASALTL 368


>YLA1_HUMAN (Q9UM01) Y+L amino acid transporter 1 (y(+)L-type amino
           acid transporter 1) (y+LAT-1) (Y+LAT1) (Monocyte amino
           acid permease 2) (MOP-2)
          Length = 511

 Score =  122 bits (305), Expect = 3e-27
 Identities = 102/390 (26%), Positives = 168/390 (42%), Gaps = 15/390 (3%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLV-GTVAREHSGPALAISFLIAGLAAGLSAFCYAE 90
           L KE+S+ + + + VG+ IG+G++V   G +    S     + + + GL +   A CYAE
Sbjct: 33  LKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGLFSVFGALCYAE 92

Query: 91  LACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPN--LAPLFGGLD 148
           L      +G++Y Y     G  +A++  W  LL     S A+      N  + PLF    
Sbjct: 93  LGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCF 152

Query: 149 NLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIV 208
             P+  SR             AA  + L+T + C  +K  T+VQ I T   V AL+ VIV
Sbjct: 153 -APYAASRL-----------LAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIV 200

Query: 209 AGGYMGFKSGWVGYELPTGYFPFGVDGMLAGSATVFFAYVGFDAVASTAEEVKNPQRDLP 268
           AG     +     +E       F V  +     +  F+Y G+D +    EE+KNP+R+LP
Sbjct: 201 AGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLP 260

Query: 269 LGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISSAFSDHGMQWAAYIINAGACTAL 328
           L IG S+ +   +Y+L +V    ++    I     ++  F+D       +II      + 
Sbjct: 261 LSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSC 320

Query: 329 ISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFSMEVSD 388
              L   I+   R+    +R+G LP   C I+     PV   +  G+ A +     ++  
Sbjct: 321 FGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQ 380

Query: 389 LAGMVSVGTLLAFTMVAISVLILRYIPPNK 418
           L    S        +  +  L LR+  P++
Sbjct: 381 LINYYSFSYWFFVGLSIVGQLYLRWKEPDR 410


>BAT1_HUMAN (P82251) B(0,+)-type amino acid transporter 1 (B(0,+)AT)
           (Glycoprotein-associated amino acid transporter b0,+AT1)
          Length = 487

 Score =  110 bits (274), Expect = 1e-23
 Identities = 102/422 (24%), Positives = 182/422 (42%), Gaps = 35/422 (8%)

Query: 17  RRKQVDSPRQNTKPL---LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAR--EHSGPALA 71
           +R++ +   Q+ +P    L KEL +   I+I VG+ IG+G++V   +V    E  GP L 
Sbjct: 8   KRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLI 67

Query: 72  ISFLIAGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAA 131
           I +   G+ A L A C+AEL      +G  Y Y     G   A+L  WA L+     S A
Sbjct: 68  I-WAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFA 126

Query: 132 VARGITPNLAPLFGGLDNLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVV 191
           +       +   F      PF++  +      IVV   AA  +L ++ +  L ++  + V
Sbjct: 127 I-------ICLSFSEYVCAPFYVGCKPP---QIVVKCLAAAAILFISTVNSLSVRLGSYV 176

Query: 192 QGIVTSVNVCALLFVIVAGGYM-------GFKSGWVGYELPTGYFPFGVDGMLAGSATVF 244
           Q I T+  +  +  +I++G  +        F + + G +L  G         L       
Sbjct: 177 QNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGL------- 229

Query: 245 FAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPI 304
           +AY G++ +    EE++NP R+LPL I   + L    Y+L++V    ++    +     +
Sbjct: 230 WAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAV 289

Query: 305 SSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTL 364
           +  F D  +  A++I+      + I A  G      R++    R+G +      I+   L
Sbjct: 290 AVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRL 349

Query: 365 VPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYI-----PPNKV 419
            P    I  G+ A +     +++ L    S    L + +  + ++++R+       P KV
Sbjct: 350 TPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKV 409

Query: 420 PV 421
           PV
Sbjct: 410 PV 411


>BAT1_RAT (P82252) B(0,+)-type amino acid transporter 1 (B(0,+)AT)
           (Glycoprotein-associated amino acid transporter b0,+AT1)
          Length = 487

 Score =  106 bits (265), Expect = 1e-22
 Identities = 95/422 (22%), Positives = 179/422 (41%), Gaps = 35/422 (8%)

Query: 17  RRKQVDSPRQNTKPL---LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAR--EHSGPALA 71
           RR++ +    +T+P    L KE+ +   I I VG+ IG+G+++   +V    E  GP L 
Sbjct: 8   RRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLI 67

Query: 72  ISFLIAGLAAGLSAFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAA 131
           I +   G+ A L A C+AEL      +G  Y Y     G   A+L  W  L+     S A
Sbjct: 68  I-WAACGVLATLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFA 126

Query: 132 VARGITPNLAPLFGGLDNLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVV 191
           +       +   F       F+L  +      +VV   AA  +LL+T +  L ++  + V
Sbjct: 127 I-------ICLSFSEYVCAAFYLGCRPPA---VVVKLLAAAAILLITTVNALSVRLGSYV 176

Query: 192 QGIVTSVNVCALLFVIVAG-------GYMGFKSGWVGYELPTGYFPFGVDGMLAGSATVF 244
           Q + T+  +  +  +I++G           F++ + G +   G         L       
Sbjct: 177 QNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSVGSISLAFYNGL------- 229

Query: 245 FAYVGFDAVASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPI 304
           +AY G++ +    EE++NP R+LP+ I   + L    Y+L+++    ++    +     +
Sbjct: 230 WAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQSQAV 289

Query: 305 SSAFSDHGMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTL 364
           +  F D  +  A++++      + I A  G      R++    R+G +      I+   L
Sbjct: 290 AVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRL 349

Query: 365 VPVKGTIITGLAAAVLAFSMEVSDLAGMVSVGTLLAFTMVAISVLILRYI-----PPNKV 419
            P    +  G+ A +     +++ L    S    L + M  + ++++R+       P KV
Sbjct: 350 TPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKV 409

Query: 420 PV 421
           P+
Sbjct: 410 PI 411


>LAT1_HUMAN (Q01650) Large neutral amino acids transporter small
           subunit 1 (L-type amino acid transporter 1) (4F2 light
           chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral
           membrane protein E16) (hLAT1)
          Length = 507

 Score =  106 bits (264), Expect = 2e-22
 Identities = 97/391 (24%), Positives = 168/391 (42%), Gaps = 19/391 (4%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIA-GLAAGLSAFCYAE 90
           L + +++ + +AI VG+ IG+G++V    V +E   P LA+    A G+ + + A CYAE
Sbjct: 46  LQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAE 105

Query: 91  LACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGI--TPNLAPLFGGLD 148
           L      +G  Y Y     G   A+L  W  LL     S  +   +  T  L PLF    
Sbjct: 106 LGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLF---- 161

Query: 149 NLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIV 208
                      P  +      A + VLL+T + C  +K +T VQ    +  + AL  +I+
Sbjct: 162 --------PTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIIL 213

Query: 209 AGGYMGFKSGWVGYELPTGYFP---FGVDGMLAGSATVFFAYVGFDAVASTAEEVKNPQR 265
            G ++    G V    P   F      V  ++    +  FAY G++ +    EE+ NP R
Sbjct: 214 LG-FVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYR 272

Query: 266 DLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPDTPISSAFSDHGMQWAAYIINAGAC 325
           +LPL I  SL +   +Y+L ++     +    +     ++  F ++ +   ++II     
Sbjct: 273 NLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVG 332

Query: 326 TALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAVLAFSME 385
            +   ++ G +    R+    +R+G LP     I+   L PV   + T +   + AFS +
Sbjct: 333 LSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKD 392

Query: 386 VSDLAGMVSVGTLLAFTMVAISVLILRYIPP 416
           +  +    S    L   +  I ++ LR+  P
Sbjct: 393 IFSVINFFSFFNWLCVALAIIGMIWLRHRKP 423


>FRLA_ECOLI (P45539) Putative fructoselysine transporter frlA
          Length = 445

 Score =  106 bits (264), Expect = 2e-22
 Identities = 104/384 (27%), Positives = 175/384 (45%), Gaps = 45/384 (11%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAI-SFLIAGLAAGLSAFCYAE 90
           L ++L  + ++AI VG+T+G+G++V VG VA+    P L + +F+I GL        YAE
Sbjct: 6   LQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYAE 65

Query: 91  LACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAV-ARGITPNLAPLFGGLDN 149
           L+   P  G+ Y Y        +A+L GWA        S ++ A  I  NL         
Sbjct: 66  LSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLG-------- 117

Query: 150 LPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCL-GIKESTVVQGIVTSVNVCALLFVIV 208
                    +  ID ++    A  +++   LL L  ++     Q ++T   +  + F IV
Sbjct: 118 --------FLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKI--IPFTIV 167

Query: 209 AG-GYMGFKSGWVGYELPTGYFPFGVDG----MLAGSATVFFAYVGFDAVASTAEEVKNP 263
            G G   FK+    +  PT     G  G    +LAG +   ++Y G  ++     E+KNP
Sbjct: 168 IGLGIFWFKAE--NFAAPTTT-AIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNP 224

Query: 264 QRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAI-DPDTPISSAFSDHGMQW------- 315
            + +P  +  S  L   +Y L+++V+ GL+P+  + + +TPIS A     + W       
Sbjct: 225 GKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDA-----LTWIPALGST 279

Query: 316 AAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGL 375
           A   +   A   ++ +L   ++ QPR+  AMA+D L    F  ++     P    I+ G 
Sbjct: 280 AGIFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQG- 338

Query: 376 AAAVLAFSMEVSDLAGMVSVGTLL 399
             A+  F + VSDL  ++   TL+
Sbjct: 339 --ALGIFFIFVSDLTSLLGYFTLV 360


>FRLA_ECO57 (Q8X845) Putative fructoselysine transporter frlA
          Length = 445

 Score =  105 bits (263), Expect = 2e-22
 Identities = 102/381 (26%), Positives = 172/381 (44%), Gaps = 39/381 (10%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAI-SFLIAGLAAGLSAFCYAE 90
           L ++L  + ++AI VG+T+G+G++V VG VA+    P L + +F+I GL        YAE
Sbjct: 6   LQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYAE 65

Query: 91  LACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAV-ARGITPNLAPLFGGLDN 149
           L+   P  G+ Y Y        +A+L GWA        S ++ A  I  NL         
Sbjct: 66  LSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLG-------- 117

Query: 150 LPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCL-GIKESTVVQGIVTSVNVCALLFVIV 208
                    +  ID ++    A  +++   LL L  ++     Q ++T   +  + F IV
Sbjct: 118 --------FLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKI--IPFTIV 167

Query: 209 AG-GYMGFKSGWVGYELPTGYFPFG-VDGMLAGSATVFFAYVGFDAVASTAEEVKNPQRD 266
            G G   FK+        T     G    +LAG +   ++Y G  ++     E+KNP + 
Sbjct: 168 IGLGIFWFKAENFAAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKT 227

Query: 267 LPLGIGASLFLCCGMYMLVSVVVVGLVPYYAI-DPDTPISSAFSDHGMQW-------AAY 318
           +P  +  S  L   +Y L+++V+ GL+P+  + + +TPIS A     + W       A  
Sbjct: 228 MPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDA-----LTWIPALGSTAGI 282

Query: 319 IINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAA 378
            +   A   ++ +L   ++ QPR+  AMA+D L    F  ++     P    I+ G   A
Sbjct: 283 FVAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQG---A 339

Query: 379 VLAFSMEVSDLAGMVSVGTLL 399
           +  F + VSDL  ++   TL+
Sbjct: 340 LGIFFIFVSDLTSLLGYFTLV 360


>ROCC_BACSU (P39636) Amino-acid permease rocC
          Length = 470

 Score =  105 bits (262), Expect = 3e-22
 Identities = 95/393 (24%), Positives = 177/393 (44%), Gaps = 44/393 (11%)

Query: 26  QNTKPLLAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAIS-FLIAGLAAGLS 84
           QN K  L + +   HL  I +G  IG G+++  G    + +GP  AI+ ++I G    L 
Sbjct: 2   QNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQ-AGPLGAIAAYIIGGFLMYLV 60

Query: 85  AFCYAELACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEY--TIGSAAVARGITPNLAP 142
             C  ELA   P AGS   Y+   LG+   ++IGW     +  T+G    + GI      
Sbjct: 61  MLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWANTVGLELTSAGI------ 114

Query: 143 LFGGLDNLPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCA 202
                      L ++ +P + I +     +  +++  +  L ++    ++   +S+ V A
Sbjct: 115 -----------LMQRWLPSVPIWI--WCLVFGIVIFLINALSVRSFAEMEFWFSSIKVAA 161

Query: 203 LLFVIVAG-----GYMGFKSG-----WVGYELPTGYFPFGVDGMLAGSATVFFAYVGFDA 252
           ++  IV G     G + FK G        +    G FP GV  ++     V F++ G + 
Sbjct: 162 IILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQGTEL 221

Query: 253 VASTAEEVKNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDP-DTPISSAFSDH 311
           V   A E ++P++ LP  I   ++     ++L   V+V ++PY      ++P  +     
Sbjct: 222 VGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVAVLDQI 281

Query: 312 GMQWAAYIINAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTI 371
           G+ ++A I+N    TA++S    G+    R++ +++ + + P F   + K   VP+   +
Sbjct: 282 GIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKG-VPMNALL 340

Query: 372 IT-GLAAAVLAFSMEVSD--------LAGMVSV 395
           IT G++   L  S+  ++        ++GMV+V
Sbjct: 341 ITLGISGCSLLTSVMAAETVYLWCISISGMVTV 373


>MMUP_ECOLI (Q47689) Probable S-methylmethionine permease
          Length = 467

 Score =  104 bits (259), Expect = 7e-22
 Identities = 88/387 (22%), Positives = 161/387 (40%), Gaps = 32/387 (8%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L + +   HLI + +G  IG G++   G +          +++LI  L   L   C  EL
Sbjct: 10  LKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALVVWLVMQCLGEL 69

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTI--GSAAVARGITPNLAPLFGGLDN 149
           +   P  G+ + Y+   LG    + + W   L +T+  GS+  A G              
Sbjct: 70  SVAMPETGAFHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAG-------------- 115

Query: 150 LPFFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALLFVIVA 209
              F  +   P + + V     +   ++ GL  +  +     +   + V V  ++  I+ 
Sbjct: 116 ---FCMQYWFPQVPVWV--WCVVFCAIIFGLNVISTRFFAEGEFWFSLVKVVTIIAFIIL 170

Query: 210 GG--YMGFKSGWVGYELP-------TGYFPFGVDGMLAGSATVFFAYVGFDAVASTAEEV 260
           GG    GF     G   P        G+FP G   +L     V FA+ G + +   A E 
Sbjct: 171 GGAAIFGFIPMQDGSPAPGLSNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGET 230

Query: 261 KNPQRDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAIDPD-TPISSAFSDHGMQWAAYI 319
           +NP++ +P+ I  ++      ++    V+  L+P   +  + +P    F   G+ +AA I
Sbjct: 231 ENPRKVIPVAIRTTIARLIIFFIGTVFVLAALIPMQQVGVEKSPFVLVFEKVGIPYAADI 290

Query: 320 INAGACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVKGTIITGLAAAV 379
            N    TA++SA   G+    R+L +++ +  LP  F  + K+  VP+    ++ L   +
Sbjct: 291 FNFVILTAILSAANSGLYASGRMLWSLSNERTLPACFARVTKNG-VPLTALSVSMLGGVL 349

Query: 380 LAFSMEVSDLAGMVSVGTLLAFTMVAI 406
             FS  V+     V++  +  F +VA+
Sbjct: 350 ALFSSVVAPDTVFVALSAISGFAVVAV 376


>GABP_BACSU (P46349) GABA permease (4-amino butyrate transport
           carrier) (Gamma-aminobutyrate permease)
          Length = 469

 Score =  103 bits (257), Expect = 1e-21
 Identities = 102/395 (25%), Positives = 178/395 (44%), Gaps = 33/395 (8%)

Query: 32  LAKELSVYHLIAIGVGSTIGAGVYVLVGTVAREHSGPALAISFLIAGLAAGLSAFCYAEL 91
           L KEL   H+  I +   IGAG++V  G V    +GP   +S+ +AGL          E+
Sbjct: 8   LKKELKTRHMTMISIAGVIGAGLFVGSGPVIHS-TGPGAVVSYALAGLLVIFIMRMLGEM 66

Query: 92  ACRCPSAGSAYHYSYICLGEGVAWLIGWALLLEYTIGSAAVARGITPNLAPLFGGLDNLP 151
           +   P++GS   Y++  +G    + IGW     + I  A  A            G   + 
Sbjct: 67  SAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVIVIAIEA----------IAGAGIIQ 116

Query: 152 FFLSRQHIPGIDIVVDPCAAILVLLVTGLLCLGIKESTVVQGIVTSVNVCALL-FVIVAG 210
           ++         DI +   + IL +++T      +K     +   + + V  ++ F+IV  
Sbjct: 117 YWFH-------DIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVTIIAFLIVGF 169

Query: 211 GYM-GFKSGW--VGYELPTG---YFPFGVDGMLAGSATVFFAYVGFDAVASTAEEVKNPQ 264
            ++ GF  G   VG+   TG   +FP G+  +L G   V F+++G + VA  A E  NP 
Sbjct: 170 AFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIVAIAAGETSNPI 229

Query: 265 RDLPLGIGASLFLCCGMYMLVSVVVVGLVPYYAID-PDTPISSAFSDHGMQWAAYIINAG 323
             +     + ++     Y+    +VV L+P+ + +  ++P  +     G+  AA I+N  
Sbjct: 230 ESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEHIGVPAAAQIMNFI 289

Query: 324 ACTALISALMGGILPQPRILMAMARDGLLPPFFCDINKHTLVPVK----GTIITGLAAAV 379
             TA++S L  G+    R+L ++A     P  F  ++K   VPV+    GT  + +A  +
Sbjct: 290 VLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKG-VPVQAIVAGTFFSYIAVVM 348

Query: 380 LAFSMEVSDLAGMVSVG--TLLAFTMVAISVLILR 412
             FS +   L  + S G   LL + ++A+S L +R
Sbjct: 349 NYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMR 383


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.326    0.143    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,269,014
Number of Sequences: 164201
Number of extensions: 2883900
Number of successful extensions: 9510
Number of sequences better than 10.0: 164
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 9139
Number of HSP's gapped (non-prelim): 230
length of query: 571
length of database: 59,974,054
effective HSP length: 116
effective length of query: 455
effective length of database: 40,926,738
effective search space: 18621665790
effective search space used: 18621665790
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 68 (30.8 bits)