BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC137823.5 - phase: 0 
         (121 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

WS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 1...    46  1e-05
HER3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3         43  1e-04
WS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 1...    42  2e-04
CEBP_HUMAN (Q9UII4) Cyclin-E binding protein 1                         42  2e-04
RCC1_SCHPO (P28745) Pim1 protein (Poly(A)+ RNA transport protein 2)    42  3e-04
ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...    41  5e-04
ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)    40  0.001
RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...    39  0.002
RCC1_CANAL (P52499) RCC1 protein                                       38  0.005
RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator     37  0.006
RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator     37  0.008
RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...    37  0.010
GNFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related p...    37  0.010
RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...    36  0.013
NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...    36  0.013
RCC1_HUMAN (P18754) Regulator of chromosome condensation (Cell c...    36  0.018
NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...    35  0.023
RCC1_MESAU (P23800) Regulator of chromosome condensation               35  0.030
NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...    35  0.030
NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...    35  0.030

>WS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16
           protein homolog
          Length = 461

 Score = 46.2 bits (108), Expect = 1e-05
 Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 10/88 (11%)

Query: 7   LGTTKPVA------ASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPA-G 59
           +G  K VA      A +  +  ++VWGY   G  G+  K  +  IP+ +PP LFG     
Sbjct: 332 VGKVKQVACGGTGCAVLNAEGHVFVWGY---GILGKGPKLLETAIPEMIPPTLFGLTEFN 388

Query: 60  LNTRWLDIACGREHTAAIASDGLLFTWG 87
              +   I CG  H AA+ + G LF WG
Sbjct: 389 PEVQVSQIRCGLSHFAALTNKGELFVWG 416



 Score = 29.6 bits (65), Expect = 1.3
 Identities = 15/72 (20%), Positives = 34/72 (46%), Gaps = 6/72 (8%)

Query: 20  KSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIAS 79
           +  ++  G N  GQ GRK  +D++        ++       + + + + CG++H+  +  
Sbjct: 189 REGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRM----QDFDGQVVQVVCGQDHSLFLTD 244

Query: 80  DGLLFT--WGLD 89
            G +++  WG D
Sbjct: 245 KGEVYSCGWGAD 256



 Score = 28.5 bits (62), Expect = 2.8
 Identities = 26/93 (27%), Positives = 38/93 (39%), Gaps = 7/93 (7%)

Query: 20  KSAIYVWGY--NQSGQTG--RKEKDDQLRIPKQLPPQLFGCPAGL--NTRWLDIACGREH 73
           K    VWG   N+  Q G  R  KD        L P     P      T+ L ++CGR H
Sbjct: 123 KDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQVSCGRAH 182

Query: 74  TAAIASDGLLFTWGLDFSYSLLVLLIVHDFIYS 106
           +  +     +F+ G + S+      +V D +YS
Sbjct: 183 SLVLTDREGVFSMG-NNSHGQCGRKVVEDEVYS 214



 Score = 28.1 bits (61), Expect = 3.7
 Identities = 17/64 (26%), Positives = 27/64 (41%), Gaps = 10/64 (15%)

Query: 15  ASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHT 74
           A++  K  ++VWG N  G  G    +D          Q F     +    +D+ACG +H 
Sbjct: 404 AALTNKGELFVWGKNIRGCLGIGRLED----------QYFPWRVTMPGEPVDVACGVDHM 453

Query: 75  AAIA 78
             +A
Sbjct: 454 VTLA 457


>HER3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3
          Length = 1050

 Score = 43.1 bits (100), Expect = 1e-04
 Identities = 21/69 (30%), Positives = 34/69 (48%), Gaps = 9/69 (13%)

Query: 20  KSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRW-LDIACGREHTAAIA 78
           +  ++ WG    GQ G    +D + +P+ +          LN +  L ++CG  H  A+A
Sbjct: 102 RGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQK--------LNQQTILQVSCGNWHCLALA 153

Query: 79  SDGLLFTWG 87
           +DG  FTWG
Sbjct: 154 ADGQFFTWG 162



 Score = 37.7 bits (86), Expect = 0.005
 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 12/68 (17%)

Query: 22  AIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGL--NTRWLDIACGREHTAAIAS 79
           A++ WG N +GQ G  ++ D     ++ P     C   L    + + I+CG EHTA +  
Sbjct: 210 AVFGWGMNNAGQLGLSDEKD-----RESP-----CHVKLLRTQKVVYISCGEEHTAVLTK 259

Query: 80  DGLLFTWG 87
            G +FT+G
Sbjct: 260 SGGVFTFG 267



 Score = 37.0 bits (84), Expect = 0.008
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 10/65 (15%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGL 82
           +Y  G N  GQ G + + ++        P+  G  A  +   + +ACG  H+ A++  G 
Sbjct: 55  VYTCGLNTKGQLGHEREGNK--------PEQIGALADQHI--IHVACGESHSLALSDRGQ 104

Query: 83  LFTWG 87
           LF+WG
Sbjct: 105 LFSWG 109



 Score = 35.0 bits (79), Expect = 0.030
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 9/74 (12%)

Query: 15  ASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHT 74
           A + +   ++ +G    GQ G    +D++   + L  +L G           IACGR+HT
Sbjct: 255 AVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVL--ELMGSEV------TQIACGRQHT 306

Query: 75  AA-IASDGLLFTWG 87
            A + S GL++ +G
Sbjct: 307 LAFVPSSGLIYAFG 320



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 26 WGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGLLFT 85
          WGY   GQ G       +       PQ+ G  +  + +  ++ACG  H+  +  DG ++T
Sbjct: 4  WGYWSLGQPGISTNLQGI----VAEPQVCGFISDRSVK--EVACGGNHSVFLLEDGEVYT 57

Query: 86 WGLD 89
           GL+
Sbjct: 58 CGLN 61


>WS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16
           protein
          Length = 464

 Score = 42.4 bits (98), Expect = 2e-04
 Identities = 23/66 (34%), Positives = 33/66 (49%), Gaps = 4/66 (6%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPA-GLNTRWLDIACGREHTAAIASDG 81
           ++VWGY   G  G+     +  +P+ +PP LFG        +   I CG  H AA+ + G
Sbjct: 357 VFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413

Query: 82  LLFTWG 87
            LF WG
Sbjct: 414 ELFVWG 419



 Score = 30.0 bits (66), Expect = 0.96
 Identities = 27/88 (30%), Positives = 37/88 (41%), Gaps = 7/88 (7%)

Query: 25  VWGY--NQSGQTG--RKEKDDQLRIPKQLPPQLFGCPAGL--NTRWLDIACGREHTAAIA 78
           VWG   N+  Q G  R  KD        L P     P      TR L ++CGR H+  + 
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190

Query: 79  SDGLLFTWGLDFSYSLLVLLIVHDFIYS 106
               +F+ G + SY      +V + IYS
Sbjct: 191 DREGVFSMG-NNSYGQCGRKVVENEIYS 217



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 15/72 (20%), Positives = 35/72 (47%), Gaps = 6/72 (8%)

Query: 20  KSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIAS 79
           +  ++  G N  GQ GRK  ++++        ++       + + + +ACG++H+  +  
Sbjct: 192 REGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM----QDFDGQVVQVACGQDHSLFLTD 247

Query: 80  DGLLFT--WGLD 89
            G +++  WG D
Sbjct: 248 KGEVYSCGWGAD 259



 Score = 28.1 bits (61), Expect = 3.7
 Identities = 17/64 (26%), Positives = 27/64 (41%), Gaps = 10/64 (15%)

Query: 15  ASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHT 74
           A++  K  ++VWG N  G  G    +D          Q F     +    +D+ACG +H 
Sbjct: 407 AALTNKGELFVWGKNIRGCLGIGRLED----------QYFPWRVTMPGEPVDVACGVDHM 456

Query: 75  AAIA 78
             +A
Sbjct: 457 VTLA 460


>CEBP_HUMAN (Q9UII4) Cyclin-E binding protein 1
          Length = 1024

 Score = 42.4 bits (98), Expect = 2e-04
 Identities = 27/69 (39%), Positives = 37/69 (53%), Gaps = 16/69 (23%)

Query: 23  IYVWGYNQSGQTG---RKEKDDQLRIPKQLPPQLFGCPAGLNTRWLD-IACGREHTAAIA 78
           IY WG N+ GQ G    + KDD         P L     GL+ + ++ +ACG  H+A + 
Sbjct: 212 IYSWGKNECGQLGLGHTESKDD---------PSLI---EGLDNQKVEFVACGGSHSALLT 259

Query: 79  SDGLLFTWG 87
            DGLLFT+G
Sbjct: 260 QDGLLFTFG 268



 Score = 35.0 bits (79), Expect = 0.030
 Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 16  SIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTA 75
           ++ +   ++ WG N  GQ G   K      P Q+   L G P         I+ G  H+ 
Sbjct: 152 ALSKGGELFAWGQNLHGQLGVGRKFPSTTTP-QIVEHLAGVPLA------QISAGEAHSM 204

Query: 76  AIASDGLLFTWG 87
           A++  G +++WG
Sbjct: 205 ALSMSGNIYSWG 216



 Score = 33.1 bits (74), Expect = 0.11
 Identities = 24/75 (32%), Positives = 37/75 (49%), Gaps = 9/75 (12%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +A + +   ++ +G  + GQ G     ++LR    L  +L G       R   IACGR H
Sbjct: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELR--PCLVAELVGY------RVTQIACGRWH 306

Query: 74  TAAIASD-GLLFTWG 87
           T A  SD G +F++G
Sbjct: 307 TLAYVSDLGKVFSFG 321



 Score = 28.1 bits (61), Expect = 3.7
 Identities = 10/23 (43%), Positives = 14/23 (60%)

Query: 65  LDIACGREHTAAIASDGLLFTWG 87
           + I CG  H+ A++  G LF WG
Sbjct: 141 IQITCGDYHSLALSKGGELFAWG 163


>RCC1_SCHPO (P28745) Pim1 protein (Poly(A)+ RNA transport protein 2)
          Length = 539

 Score = 41.6 bits (96), Expect = 3e-04
 Identities = 22/72 (30%), Positives = 40/72 (55%), Gaps = 4/72 (5%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGL 82
           +YV+G     + G  E++  +    +L P L     G+    +D+A G  H+AA++ DG 
Sbjct: 73  VYVFGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGV----VDLAVGGMHSAALSHDGR 128

Query: 83  LFTWGLDFSYSL 94
           ++TWG++  Y+L
Sbjct: 129 VYTWGVNDDYAL 140



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 7/81 (8%)

Query: 16  SIPRKSAIYVWGYNQSGQTGRKEKDDQ--LRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +I  K  +Y WG N + Q G + +D++    I K   P L     G N +   I  G  H
Sbjct: 293 AIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITK---PTLVDALEGYNVK--SITGGEHH 347

Query: 74  TAAIASDGLLFTWGLDFSYSL 94
           T A+  DG +  WG D  + L
Sbjct: 348 TLALLEDGRVLAWGRDDRHQL 368



 Score = 37.4 bits (85), Expect = 0.006
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 6/80 (7%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLF-GCPAGL-----NTRWLDI 67
           +A++     +Y WG N     GR  KD +     ++   L  G P+ +     + R   +
Sbjct: 120 SAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKV 179

Query: 68  ACGREHTAAIASDGLLFTWG 87
            C    TAAI  +G  FTWG
Sbjct: 180 ICSDNLTAAITDNGCCFTWG 199



 Score = 32.7 bits (73), Expect = 0.15
 Identities = 11/33 (33%), Positives = 19/33 (57%)

Query: 62  TRWLDIACGREHTAAIASDGLLFTWGLDFSYSL 94
           T  + + CG  H  A+ SDG +++WG   +Y +
Sbjct: 400 TNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEV 432



 Score = 32.7 bits (73), Expect = 0.15
 Identities = 25/84 (29%), Positives = 39/84 (45%), Gaps = 9/84 (10%)

Query: 8   GTTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDI 67
           GT   +A +   K  +Y WG  Q  Q GR+  +   R  + L PQ    P  L    + +
Sbjct: 234 GTDHIIALTTTGK--VYTWGNGQQFQLGRRMLER--RRLQGLTPQ----PLALKNI-ISV 284

Query: 68  ACGREHTAAIASDGLLFTWGLDFS 91
             G  H+ AI + G ++ WGL+ +
Sbjct: 285 GAGSYHSFAIDNKGRVYAWGLNIT 308


>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2
           homolog)
          Length = 1651

 Score = 40.8 bits (94), Expect = 5e-04
 Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 5/84 (5%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAG--LNTRWLDIACGR 71
           + ++     +Y+WG N +GQ       +Q  +P+  P  +        L  R L +ACG 
Sbjct: 103 SGAVTESGVVYMWGENAAGQCAVA---NQQYVPEPSPVSISDSETSPSLAVRILQLACGE 159

Query: 72  EHTAAIASDGLLFTWGLDFSYSLL 95
           EHT A++    ++ WG      L+
Sbjct: 160 EHTLALSLSREIWAWGTGCQLGLI 183


>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)
          Length = 1657

 Score = 40.0 bits (92), Expect = 0.001
 Identities = 23/84 (27%), Positives = 38/84 (44%), Gaps = 5/84 (5%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAG--LNTRWLDIACGR 71
           + ++      Y+WG N +GQ       +Q  +P+  P  +    A   L  R L +ACG 
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVA---NQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159

Query: 72  EHTAAIASDGLLFTWGLDFSYSLL 95
           EHT A++    ++ WG      L+
Sbjct: 160 EHTLALSISREIWAWGTGCQLGLI 183


>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator
           (mRpgr)
          Length = 1001

 Score = 38.9 bits (89), Expect = 0.002
 Identities = 22/74 (29%), Positives = 39/74 (51%), Gaps = 10/74 (13%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +A++     +++WG N  GQ G ++K + + IP ++         G    W  I+CG  H
Sbjct: 152 SAALTEDGKLFMWGDNSEGQIGLEDKSN-VCIPHEVT-------VGKPISW--ISCGYYH 201

Query: 74  TAAIASDGLLFTWG 87
           +A +  DG L+T+G
Sbjct: 202 SAFVTMDGELYTFG 215



 Score = 30.4 bits (67), Expect = 0.74
 Identities = 20/65 (30%), Positives = 29/65 (43%), Gaps = 7/65 (10%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGL 82
           +Y  G N  GQ G  + DD+          +F  PA    +   ++ G   +AA+  DG 
Sbjct: 108 VYAAGGNNEGQLGLGDTDDR----DTFHQIVFFTPADTIKQ---LSAGANTSAALTEDGK 160

Query: 83  LFTWG 87
           LF WG
Sbjct: 161 LFMWG 165



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 19/71 (26%), Positives = 33/71 (45%), Gaps = 13/71 (18%)

Query: 20  KSAIYVWGYNQSGQTGRKE---KDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAA 76
           +  +Y +G  Q GQ G      +  + +I +++  Q          +   I+CG  HTA 
Sbjct: 260 EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQ----------KICHISCGENHTAL 309

Query: 77  IASDGLLFTWG 87
           +   GLL+T+G
Sbjct: 310 MTELGLLYTFG 320



 Score = 27.7 bits (60), Expect = 4.8
 Identities = 17/75 (22%), Positives = 39/75 (51%), Gaps = 8/75 (10%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +A +     +Y +G  ++G+ G     ++L +  + P ++ G P     R + +ACG  H
Sbjct: 202 SAFVTMDGELYTFGEPENGKLGLP---NELLMNHRSPQRVLGIPE----RVIQVACGGGH 254

Query: 74  TAAIASDGLLFTWGL 88
           T  + ++ +++ +GL
Sbjct: 255 T-VVLTEKVVYAFGL 268


>RCC1_CANAL (P52499) RCC1 protein
          Length = 464

 Score = 37.7 bits (86), Expect = 0.005
 Identities = 24/79 (30%), Positives = 34/79 (42%), Gaps = 15/79 (18%)

Query: 16  SIPRKSAIYVWGYNQSGQ------TGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWL-DIA 68
           +I     +Y WG NQ GQ       G  E    L  P  +P         L+ + + +IA
Sbjct: 265 AIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPE--------LSHKGIKEIA 316

Query: 69  CGREHTAAIASDGLLFTWG 87
            G  HT A+  DG ++ WG
Sbjct: 317 AGEHHTLALTEDGQVYAWG 335



 Score = 28.5 bits (62), Expect = 2.8
 Identities = 19/67 (28%), Positives = 33/67 (48%), Gaps = 4/67 (5%)

Query: 23 IYVWGYNQSGQTGR--KEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASD 80
          ++VWG     + G     K+ +++ P+ L P L     G  T+ +D A G  HT A+   
Sbjct: 26 VFVWGTGSMCELGLGPSAKNKEVKRPR-LNPYLTEEKLG-GTKIVDFAVGGMHTLALDGK 83

Query: 81 GLLFTWG 87
            +++WG
Sbjct: 84 NRIWSWG 90



 Score = 28.1 bits (61), Expect = 3.7
 Identities = 20/82 (24%), Positives = 31/82 (37%), Gaps = 21/82 (25%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPK-QLPPQLFGCPAGLN-----------TRWLDIACG 70
           +Y WG     + G         IPK +LP   F    G +            +   I  G
Sbjct: 331 VYAWGRYDMKEIG---------IPKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVG 381

Query: 71  REHTAAIASDGLLFTWGLDFSY 92
             H+ A+  DG+++ WG   +Y
Sbjct: 382 SHHSFAVTEDGVVYAWGFAETY 403


>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator
          Length = 1020

 Score = 37.4 bits (85), Expect = 0.006
 Identities = 21/74 (28%), Positives = 38/74 (50%), Gaps = 10/74 (13%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +A++     +++WG N  GQ G K   + + +P+Q+         G    W  I+CG  H
Sbjct: 152 SAALTEDGRLFMWGDNSEGQIGLKNVSN-VCVPQQVT-------IGKPVSW--ISCGYYH 201

Query: 74  TAAIASDGLLFTWG 87
           +A + +DG L+ +G
Sbjct: 202 SAFVTTDGELYVFG 215



 Score = 31.2 bits (69), Expect = 0.43
 Identities = 20/69 (28%), Positives = 33/69 (46%), Gaps = 9/69 (13%)

Query: 20  KSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLD-IACGREHTAAIA 78
           ++A+Y +G  Q GQ G      +   PK +          +  + +  I+CG  HTA I 
Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--------NIRDQTISYISCGENHTALIT 311

Query: 79  SDGLLFTWG 87
             GL++T+G
Sbjct: 312 DIGLMYTFG 320



 Score = 29.3 bits (64), Expect = 1.6
 Identities = 21/80 (26%), Positives = 40/80 (49%), Gaps = 18/80 (22%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQL-----PPQLFGCPAGLNTRWLDIA 68
           +A +     +YV+G  ++G+ G         +P QL      PQL    + +  + + +A
Sbjct: 202 SAFVTTDGELYVFGEPENGKLG---------LPNQLLGNHRTPQLV---SEIPEKVIQVA 249

Query: 69  CGREHTAAIASDGLLFTWGL 88
           CG EHT  + ++  ++T+GL
Sbjct: 250 CGGEHT-VVLTENAVYTFGL 268


>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator
          Length = 1003

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 21/74 (28%), Positives = 38/74 (50%), Gaps = 10/74 (13%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +A++     +++WG N  GQ G  E    + +P+Q+         G    W  I+CG  H
Sbjct: 152 SAALTEDGELFMWGDNSEGQIGL-ENVTNVCVPQQVT-------VGKPISW--ISCGYYH 201

Query: 74  TAAIASDGLLFTWG 87
           +A + ++G L+T+G
Sbjct: 202 SAFVTTEGQLYTFG 215



 Score = 33.9 bits (76), Expect = 0.067
 Identities = 21/68 (30%), Positives = 32/68 (46%), Gaps = 7/68 (10%)

Query: 20  KSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIAS 79
           + A+Y +G  Q GQ G      +  +PK +           + +   IACG  HTA I  
Sbjct: 260 EKAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIK-------DQKISFIACGENHTALITD 312

Query: 80  DGLLFTWG 87
            GL++T+G
Sbjct: 313 MGLMYTFG 320


>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20
           protein) (Pheromone response pathway component SRM1)
          Length = 482

 Score = 36.6 bits (83), Expect = 0.010
 Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 7/73 (9%)

Query: 17  IPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAA 76
           +  +  ++ WG  Q  Q GRK  + + R+ K L P+ FG     + ++  IA G  H  A
Sbjct: 236 LDEEGMVFAWGNGQQNQLGRKVME-RFRL-KTLDPRPFGLR---HVKY--IASGENHCFA 288

Query: 77  IASDGLLFTWGLD 89
           +  D  L +WGL+
Sbjct: 289 LTKDNKLVSWGLN 301



 Score = 31.6 bits (70), Expect = 0.33
 Identities = 12/40 (30%), Positives = 24/40 (60%), Gaps = 2/40 (5%)

Query: 57  PAGLNT--RWLDIACGREHTAAIASDGLLFTWGLDFSYSL 94
           P  LN   ++  +A G  H+ A+A +G+ ++WG   +Y++
Sbjct: 387 PTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAV 426



 Score = 28.1 bits (61), Expect = 3.7
 Identities = 16/81 (19%), Positives = 35/81 (42%), Gaps = 4/81 (4%)

Query: 7   LGTTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLD 66
           L  T  ++ ++     +Y WG  +  +       D+++I K      +  P       + 
Sbjct: 170 LAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTP----WKVPTFSKYNIVQ 225

Query: 67  IACGREHTAAIASDGLLFTWG 87
           +A G++H   +  +G++F WG
Sbjct: 226 LAPGKDHILFLDEEGMVFAWG 246


>GNFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related
           protein (Deafness locus associated putative guanine
           nucleotide exchange factor) (DelGEF)
          Length = 458

 Score = 36.6 bits (83), Expect = 0.010
 Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 11/74 (14%)

Query: 23  IYVWGYNQSGQTGRK---------EKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           ++ WG    GQ GRK         EK D   +P   PP          T   +++CG EH
Sbjct: 286 MFTWGRADYGQLGRKLETYEGWKLEKQDSF-LPCSRPPNSMPSSPHCLTGATEVSCGSEH 344

Query: 74  TAAIASDGLLFTWG 87
             AI   G+ ++WG
Sbjct: 345 NLAIIG-GVCYSWG 357



 Score = 36.2 bits (82), Expect = 0.013
 Identities = 25/72 (34%), Positives = 35/72 (47%), Gaps = 7/72 (9%)

Query: 18 PRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAI 77
          P  +A++ WG N  GQ G   K+D L +P+QL    F  P  +      I  G  H+A +
Sbjct: 12 PAAAALFAWGANSYGQLGLGHKEDVL-LPQQLND--FCKPRSVRR----ITGGGGHSAVV 64

Query: 78 ASDGLLFTWGLD 89
             G LF  GL+
Sbjct: 65 TDGGDLFVCGLN 76



 Score = 35.0 bits (79), Expect = 0.030
 Identities = 22/74 (29%), Positives = 33/74 (43%), Gaps = 7/74 (9%)

Query: 14  AASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREH 73
           +AS+     +YVWG N+ GQ   +     L +P+++    F      N +   I  G  H
Sbjct: 224 SASLTDAGEVYVWGSNKHGQLANEAA--FLPVPQKIEAHCF-----QNEKVTAIWSGWTH 276

Query: 74  TAAIASDGLLFTWG 87
             A    G +FTWG
Sbjct: 277 LVAQTETGKMFTWG 290


>RCC1_DROME (P25171) Regulator of chromosome condensation
           (Chromatin-binding protein Bj1)
          Length = 547

 Score = 36.2 bits (82), Expect = 0.013
 Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 8/71 (11%)

Query: 17  IPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAA 76
           + +   IY +G N  G  GR   +D      +  P L   P     + L I+ G  H+A 
Sbjct: 89  LTKSGDIYSFGCNDEGALGRDTSEDG----SESKPDLIDLPG----KALCISAGDSHSAC 140

Query: 77  IASDGLLFTWG 87
           +  DG +F WG
Sbjct: 141 LLEDGRVFAWG 151


>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC
           2.7.1.37) (NimA-related protein kinase 8)
          Length = 697

 Score = 36.2 bits (82), Expect = 0.013
 Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 12/81 (14%)

Query: 7   LGTTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLD 66
           +GT   VA  +  K   + +G NQ GQ G   +    R+P Q+        +GL    + 
Sbjct: 575 IGTAHSVA--VTEKGQCFTFGSNQHGQLGCSHRRSS-RVPYQV--------SGLQGITM- 622

Query: 67  IACGREHTAAIASDGLLFTWG 87
            ACG   T AI ++G ++TWG
Sbjct: 623 AACGDAFTLAIGAEGEVYTWG 643



 Score = 29.6 bits (65), Expect = 1.3
 Identities = 13/34 (38%), Positives = 19/34 (55%)

Query: 16  SIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQL 49
           +I  +  +Y WG    G+ GRKE+D  +  P QL
Sbjct: 632 AIGAEGEVYTWGKGARGRLGRKEEDFGIPKPVQL 665


>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Cell
           cycle regulatory protein)
          Length = 421

 Score = 35.8 bits (81), Expect = 0.018
 Identities = 19/71 (26%), Positives = 34/71 (47%), Gaps = 8/71 (11%)

Query: 17  IPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAA 76
           + +   +Y +G N  G  GR   D  +   + +P ++      L  + + ++ G  HTAA
Sbjct: 82  LSKSGQVYSFGCNDEGALGR---DTSVEGSEMVPGKV-----ELQEKVVQVSAGDSHTAA 133

Query: 77  IASDGLLFTWG 87
           +  DG +F WG
Sbjct: 134 LTDDGRVFLWG 144



 Score = 30.8 bits (68), Expect = 0.56
 Identities = 20/71 (28%), Positives = 32/71 (44%), Gaps = 9/71 (12%)

Query: 24  YVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGLL 83
           Y  G  + G+ G  E  ++    K +P  +   PA  +     +ACG     A+  DG +
Sbjct: 316 YSLGRAEYGRLGLGEGAEE----KSIPTLISRLPAVSS-----VACGASVGYAVTKDGRV 366

Query: 84  FTWGLDFSYSL 94
           F WG+  +Y L
Sbjct: 367 FAWGMGTNYQL 377



 Score = 27.3 bits (59), Expect = 6.2
 Identities = 21/82 (25%), Positives = 38/82 (45%), Gaps = 12/82 (14%)

Query: 23  IYVWGYNQSGQTGR----------KEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGRE 72
           +Y  G  + GQ GR          ++  ++L +PK +  +  G     + R+ D  CG  
Sbjct: 193 LYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG--HVRFQDAFCGAY 250

Query: 73  HTAAIASDGLLFTWGLDFSYSL 94
            T AI+ +G ++ +GL   + L
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQL 272


>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC
           2.7.1.37) (NimA-related protein kinase 9) (XNek9)
           (Nercc1 kinase)
          Length = 944

 Score = 35.4 bits (80), Expect = 0.023
 Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 7/73 (9%)

Query: 15  ASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHT 74
           A+I  +  +  +G N+ GQ G  +    L I       L G P G   + + ++CG E T
Sbjct: 592 AAIDERGRLLTFGSNKCGQLGVGDYRKHLGI------NLLGGPLG-GKQVIRVSCGDEFT 644

Query: 75  AAIASDGLLFTWG 87
            A  +D  +F WG
Sbjct: 645 TAATADNHIFAWG 657



 Score = 27.3 bits (59), Expect = 6.2
 Identities = 16/74 (21%), Positives = 35/74 (46%), Gaps = 8/74 (10%)

Query: 16  SIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTA 75
           ++ R  ++Y WG  + G+ G   +DD +  P+++  Q   C        +++ CG + + 
Sbjct: 476 ALTRSKSVYSWGCGEYGRLGLDSEDD-VYSPQKVEVQRGLC-------IVNVCCGSDGSF 527

Query: 76  AIASDGLLFTWGLD 89
            +   G +   GL+
Sbjct: 528 LLTLTGKVLACGLN 541



 Score = 27.3 bits (59), Expect = 6.2
 Identities = 20/78 (25%), Positives = 27/78 (33%), Gaps = 19/78 (24%)

Query: 9   TTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIA 68
           T  P+A    R S +YVWG                   K  P +L     G   R   + 
Sbjct: 317 TEAPIAVVTSRSSEVYVWGGG-----------------KTTPQKLDVFKGGWRAR--QVC 357

Query: 69  CGREHTAAIASDGLLFTW 86
            G  H A +  +  L+TW
Sbjct: 358 AGDAHFAVVTVEKELYTW 375


>RCC1_MESAU (P23800) Regulator of chromosome condensation
          Length = 421

 Score = 35.0 bits (79), Expect = 0.030
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 8/65 (12%)

Query: 23  IYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACGREHTAAIASDGL 82
           +Y +G N  G  GR   D  +   + +P ++      L  + + ++ G  HTAA+  DG 
Sbjct: 88  VYSFGCNDEGALGR---DTSVEGSEMVPGKV-----ELQEKVVQVSAGDSHTAALTEDGR 139

Query: 83  LFTWG 87
           +F WG
Sbjct: 140 VFLWG 144



 Score = 30.4 bits (67), Expect = 0.74
 Identities = 11/28 (39%), Positives = 17/28 (60%)

Query: 67  IACGREHTAAIASDGLLFTWGLDFSYSL 94
           +ACG     A++ DG +F WG+  +Y L
Sbjct: 350 VACGASVGYAVSKDGRVFAWGMGTNYQL 377


>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC
           2.7.1.37) (NimA-related protein kinase 9)
          Length = 984

 Score = 35.0 bits (79), Expect = 0.030
 Identities = 23/77 (29%), Positives = 34/77 (43%), Gaps = 7/77 (9%)

Query: 11  KPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACG 70
           K   A+I  +  +  +G N+ GQ G      +L I       L G P G   + + ++CG
Sbjct: 606 KTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI------NLLGGPLG-GKQVIRVSCG 658

Query: 71  REHTAAIASDGLLFTWG 87
            E T A   D  +F WG
Sbjct: 659 DEFTIAATDDNHIFAWG 675



 Score = 31.2 bits (69), Expect = 0.43
 Identities = 21/78 (26%), Positives = 30/78 (37%), Gaps = 19/78 (24%)

Query: 9   TTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIA 68
           T  P+A    R S +YVWG  +S              P++L     GC A        + 
Sbjct: 335 TEAPIAVVTSRTSEVYVWGGGKS-------------TPQKLDVIKSGCSA------RQVC 375

Query: 69  CGREHTAAIASDGLLFTW 86
            G  H A +  +  L+TW
Sbjct: 376 AGNTHFAVVTVEKELYTW 393


>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC
           2.7.1.37) (NimA-related protein kinase 9) (Nercc1
           kinase) (NIMA-related kinase 8) (Nek8)
          Length = 979

 Score = 35.0 bits (79), Expect = 0.030
 Identities = 23/77 (29%), Positives = 34/77 (43%), Gaps = 7/77 (9%)

Query: 11  KPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIACG 70
           K   A+I  +  +  +G N+ GQ G      +L I       L G P G   + + ++CG
Sbjct: 606 KTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI------NLLGGPLG-GKQVIRVSCG 658

Query: 71  REHTAAIASDGLLFTWG 87
            E T A   D  +F WG
Sbjct: 659 DEFTIAATDDNHIFAWG 675



 Score = 31.2 bits (69), Expect = 0.43
 Identities = 21/78 (26%), Positives = 30/78 (37%), Gaps = 19/78 (24%)

Query: 9   TTKPVAASIPRKSAIYVWGYNQSGQTGRKEKDDQLRIPKQLPPQLFGCPAGLNTRWLDIA 68
           T  P+A    R S +YVWG  +S              P++L     GC A        + 
Sbjct: 335 TEAPIAVVTSRTSEVYVWGGGKS-------------TPQKLDVIKSGCSA------RQVC 375

Query: 69  CGREHTAAIASDGLLFTW 86
            G  H A +  +  L+TW
Sbjct: 376 AGNTHFAVVTVEKELYTW 393


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.326    0.143    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,650,811
Number of Sequences: 164201
Number of extensions: 570098
Number of successful extensions: 1427
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1294
Number of HSP's gapped (non-prelim): 116
length of query: 121
length of database: 59,974,054
effective HSP length: 97
effective length of query: 24
effective length of database: 44,046,557
effective search space: 1057117368
effective search space used: 1057117368
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 58 (26.9 bits)