BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC137821.2 + phase: 0 /pseudo
(428 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
VDP_HUMAN (O60763) General vesicular transport factor p115 (Tran... 52 2e-06
CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein) 51 7e-06
MYSJ_DICDI (P54697) Myosin IJ heavy chain 50 9e-06
ERC1_RAT (Q811U3) ERC protein 1 (CAZ-associated structural prote... 50 1e-05
CENF_HUMAN (P49454) CENP-F kinetochore protein (Centromere prote... 50 1e-05
MYSN_ACACA (P05659) Myosin II heavy chain, non muscle 49 2e-05
ERC1_MOUSE (Q99MI1) ERC protein 1 (Rab6-interacting protein 2) (... 49 2e-05
C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 1... 49 2e-05
PLE1_CRIGR (Q9JI55) Plectin 1 (PLTN) (PCN) (300-kDa intermediate... 49 3e-05
MYSS_RABIT (P02562) Myosin heavy chain, skeletal muscle (Fragments) 49 3e-05
ERC1_HUMAN (Q8IUD2) ERC protein 1 (ELKS protein) 49 3e-05
GCC2_MOUSE (Q8CHG3) GRIP and coiled-coil domain-containing prote... 48 4e-05
RA50_YEAST (P12753) DNA repair protein RAD50 (153 kDa protein) 47 1e-04
MYSN_DROME (Q99323) Myosin heavy chain, non-muscle (Zipper prote... 47 1e-04
M18A_HUMAN (Q92614) Myosin XVIIIA (Myosin 18A) (Myosin containin... 47 1e-04
MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (S... 46 2e-04
M18A_MOUSE (Q9JMH9) Myosin XVIIIA (Myosin 18A) (Myosin containin... 46 2e-04
MYH6_RAT (P02563) Myosin heavy chain, cardiac muscle alpha isofo... 46 2e-04
MYH6_HUMAN (P13533) Myosin heavy chain, cardiac muscle alpha iso... 46 2e-04
PLE1_HUMAN (Q15149) Plectin 1 (PLTN) (PCN) (Hemidesmosomal prote... 45 4e-04
>VDP_HUMAN (O60763) General vesicular transport factor p115
(Transcytosis associated protein) (TAP) (Vesicle docking
protein)
Length = 962
Score = 52.4 bits (124), Expect = 2e-06
Identities = 65/329 (19%), Positives = 138/329 (41%), Gaps = 19/329 (5%)
Query: 12 IYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVE 71
IY ED K ++ + K L+ + + + + + E + L+QQ++ + E
Sbjct: 628 IYKSSEED--KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE----LRQQVSTLKCQNE 681
Query: 72 DLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNE 131
L+ ++V +I + K Q + ++ + Q +G + + E++G+L+ + E
Sbjct: 682 QLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEE 741
Query: 132 LQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETL-AR 190
L+ + + ++ S I + + + +E + I S DS A+ TL ++
Sbjct: 742 LKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAI-VSARDSEQVAELKQELATLKSQ 800
Query: 191 LNES---VLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIH 247
LN + L+ EKQ+ LQK + + + G T DV G +SA + E
Sbjct: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETK-- 858
Query: 248 GSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQK-----ELAFKRQNELEEIHRGAHMD 302
L N+I + + L+ S + + +K E+ ++ + + + A D
Sbjct: 859 -ELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQD 917
Query: 303 MDAKAARQILTDLIGNIDMSELLQGMDKQ 331
+ + L DL ++ + L+ D++
Sbjct: 918 QKILSLKNKLKDLGHPVEEEDELESGDQE 946
>CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein)
Length = 2663
Score = 50.8 bits (120), Expect = 7e-06
Identities = 65/351 (18%), Positives = 150/351 (42%), Gaps = 27/351 (7%)
Query: 6 EQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLAN 65
+QE +I H +++ + D L ++ + +EI+N+ L LK Q
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL-------EHSNDALKAQDLK 1771
Query: 66 IIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQ-----SKGVTDQDVDQCDLTME 120
I + KE+ + I +++ +S+ + +K Q S + + +
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSE-KTDKLSNMQKDLENSNAKLQEKIQELKANEH 1830
Query: 121 KLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQ 180
+L LK +NE Q +K +++K I S + + I+ + +H +L + + +
Sbjct: 1831 QLITLKKDVNETQ-KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMK 1889
Query: 181 QSISDETLARLNESVLLLKQEKQQSLQKVQF----LEELWDFMGITTDEQKAVCDDVIGL 236
+ + L R+ E++ L + + ++SLQ+ + +++ + + E K D +
Sbjct: 1890 ER---DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK 1946
Query: 237 ISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEEIH 296
IS ++S + D+ K D +++Q L +++ K ++ K+ NE+E++
Sbjct: 1947 ISEKTIQIS---DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003
Query: 297 RGAHMDMDAKAAR---QILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRD 344
+ + K Q+ L +++ ++ ++R+ KE + RD
Sbjct: 2004 KQFEPNYLCKCEMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERD 2054
Score = 37.0 bits (84), Expect = 0.097
Identities = 64/357 (17%), Positives = 145/357 (39%), Gaps = 49/357 (13%)
Query: 16 KVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRF 75
+VE+ +K K ++ L + Q ++ N+ + E + + LK +L N +E +
Sbjct: 1124 EVEEKLKEK---SQQLQEKQQQLLNVQEEMSEMQKKINEIEN-LKNELKNKELTLEHMET 1179
Query: 76 KKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQ-- 133
++ E +++ E ++ I E+ + + + + D L+ ++ E++
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH----------LRGYIREIEAT 1229
Query: 134 -----NEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETL 188
E I H +K H TI EL +S ++I+N L S Q+ I
Sbjct: 1230 GLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN--TQDLEKSHTKLQEEI----- 1282
Query: 189 ARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIHG 248
VL +QE +++KV +E + + + T++ + I ++
Sbjct: 1283 -----PVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 249 SLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEEIHRGAHMDMDAKAA 308
S + +K + E L+ + + E + KE + +++E ++ K
Sbjct: 1338 QESQEEIKSLTKERDNLKTI--KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 309 RQILTDLIGNIDM-----SELLQ------GMDKQIRKAKEQAQS---RRDIIDRVAE 351
T ++ ++ S LL+ G+ K+++++ ++ +S +D + R+ E
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQE 1452
Score = 35.8 bits (81), Expect = 0.22
Identities = 48/229 (20%), Positives = 108/229 (46%), Gaps = 28/229 (12%)
Query: 14 HRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQ---LANIIPVV 70
H +++ K KD L ++ + QSE + ++ E + LK L +
Sbjct: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 71 EDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLN 130
+LR E+ EI I+ Q+ I + Q+K + + + L ++++ +++ ++N
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKL----QNK-IQEIYEKEEQLNIKQISEVQENVN 1548
Query: 131 ELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISD-ETLA 189
EL+ K H+K K SA+ SI+ S++L + L +S Q I + E +
Sbjct: 1549 ELKQFK--EHRKAKD--------SALQSIE-SKMLE-LTNRLQESQEEIQIMIKEKEEMK 1596
Query: 190 RLNESVLLLKQEKQQSLQKV-----QFLEELWDFMGIT--TDEQKAVCD 231
R+ E++ + + + +++ +++ + E+ + F+ +T + Q+ +C+
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Score = 32.0 bits (71), Expect = 3.1
Identities = 75/367 (20%), Positives = 158/367 (42%), Gaps = 47/367 (12%)
Query: 81 VKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKNIRH 140
+K++ + S +++I+ E+ C + ++D D +EK +L + LQ + ++
Sbjct: 2132 MKKLKYVLSYVTKIKEEQHEC-----INKFEMDFID-EVEKQKELLIKIQHLQQDCDVPS 2185
Query: 141 QKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQ 200
++++ +L+ M + I EIL D S SI E + VL ++
Sbjct: 2186 RELRD-----LKLNQNMDLHIEEILK-------DFSESEFPSIKTEF-----QQVLSNRK 2228
Query: 201 EKQQSLQK---VQF-LEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVK 256
E Q L++ +F +E+L + + D V + I A ++E + S I K
Sbjct: 2229 EMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK 2288
Query: 257 QVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEEIHRGAHMDMDAKAARQILTDLI 316
+ + +++ L+ N K + + + + N + ++ H+ A Q+ T+ I
Sbjct: 2289 EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV---TSRATQLTTEKI 2345
Query: 317 GNIDMS-----ELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEEKWLDEYERFI*S 371
++ S E + +I K +++ + DII ++ E K L++ + I
Sbjct: 2346 RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQA--KVHESNKCLEKTKETIQV 2403
Query: 372 VRRKRGFLSPRFH--------LW*RI*LQK*KHGRQTKKKVSYMKSLHEY--NVQRQLRE 421
++ K + + +I L+K K+ ++ +K++S K+ EY V R LRE
Sbjct: 2404 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2463
Query: 422 EEKRKSR 428
+R +
Sbjct: 2464 NLRRSQQ 2470
>MYSJ_DICDI (P54697) Myosin IJ heavy chain
Length = 2245
Score = 50.4 bits (119), Expect = 9e-06
Identities = 71/306 (23%), Positives = 128/306 (41%), Gaps = 30/306 (9%)
Query: 11 EIYHRKVEDTIKHKDY--LNKVLDDFQSEIANIAS----------SLGEDYVSFSRGKGT 58
EI K ++ +DY L+ + D+ + ++ + SLG+ F G
Sbjct: 1144 EIQQLKKANSTLEEDYFSLSGIRDNLERQVLELRDENQLIKERLDSLGQQSSQFQSGAAL 1203
Query: 59 LKQQLANIIPVVEDLRFK-KKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDL 117
KQQL ++ + K E++ E K QI+Q+ E + Q +Q +
Sbjct: 1204 EKQQLEQLVQEQSEQLIKLSSEKLGSEEEAKKQINQLELELTDHKSKLQIQLQLTEQSN- 1262
Query: 118 TMEKLGKLKSHLNELQNEKNIRHQKV----KSHISTISELSAVMSIDISEILNGIHPSLN 173
EK+ KLK L E Q+EK Q++ +S S E +++++ + S N
Sbjct: 1263 --EKIKKLKGKLEEYQDEKKQLQQELERIKQSKQSVEDEKNSLITQLTTVKFESTQVSTN 1320
Query: 174 DSSNGAQQSISDETLARLNESVLLLKQE---KQQSLQKVQFLEELWDFMGITTDEQKAVC 230
S + + T+ LN+S+ L+ E K ++K+QF EL D T + K
Sbjct: 1321 VSHQKEKITTLKSTIEELNKSIGKLQAEQKNKDDEIRKIQF--ELNDQKQQFTRQTKEFS 1378
Query: 231 D-DVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQ 289
D I E++IH + + D E +V K +E ++ K+ + +
Sbjct: 1379 DLQSQQSIDRPKSEITIHSLERTNETLKSDFE----RVQQSLKQQERDCQQYKDTINRLE 1434
Query: 290 NELEEI 295
NE++++
Sbjct: 1435 NEVKQL 1440
>ERC1_RAT (Q811U3) ERC protein 1 (CAZ-associated structural protein
2) (CAST2)
Length = 948
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/363 (19%), Positives = 155/363 (42%), Gaps = 49/363 (13%)
Query: 3 LQIEQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGED--YVSFSRGKGTLK 60
+++ + +S+ K+ + + L Q+++ + + + ++ + T K
Sbjct: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
Query: 61 QQLANIIPV-VEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTM 119
+Q A I+ V+ LR + +E+ + + QI + EK G G D D+
Sbjct: 486 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK---GTQAGEIHDLKDMLDVKE 542
Query: 120 EKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGA 179
K+ L+ + LQ + + +++ S + L A + + L + +L D
Sbjct: 543 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT-NTDTALTTLEEALADK---- 597
Query: 180 QQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISA 239
+ T+ RL E ++EKQ+ + + ++L D E+ ++ + A
Sbjct: 598 -----ERTIERLKEQRDRDEREKQEEIDT--YKKDLKDLK-----EKVSLLQGDLSEKEA 645
Query: 240 SVDEVSIHGS--LSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEEIHR 297
S+ ++ H S S+ + K RL+ L E +++KE K +++L++ H
Sbjct: 646 SLLDLKEHASSLASSGLKKD-----SRLKTL------EIALEQKKEECLKMESQLKKAHE 694
Query: 298 GAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKSAAE 357
++A+A+ + MS+ +Q ++++I + K+++ + +DR+ E E
Sbjct: 695 AT---LEARASPE----------MSDRIQQLEREIARYKDESSKAQTEVDRLLEILKEVE 741
Query: 358 EEK 360
EK
Sbjct: 742 NEK 744
Score = 44.7 bits (104), Expect = 5e-04
Identities = 61/321 (19%), Positives = 143/321 (44%), Gaps = 36/321 (11%)
Query: 59 LKQQLANIIPV-VEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDL 117
+K++ N++ +E+L+ + +++ K++ +K ++ ++A+ + ++ + +
Sbjct: 540 VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKER 599
Query: 118 TMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSN 177
T+E+L K + + EK K + + E +++ D+SE + +S+
Sbjct: 600 TIERL---KEQRDRDEREKQEEIDTYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 656
Query: 178 GAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCD--DVIG 235
A + ++ RL + L+Q+K++ L+ L++ + T E +A + D I
Sbjct: 657 LASSGLKKDS--RLKTLEIALEQKKEECLKMESQLKKAHE----ATLEARASPEMSDRIQ 710
Query: 236 LISASVDEVSIHGSLSN-------DIVKQV-------DVEVQRLQVLNPSKMKEFVFKRQ 281
+ + S + +I+K+V D ++ L+ L ++K+ +
Sbjct: 711 QLEREIARYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKD----QN 766
Query: 282 KELAFKRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQS 341
K++A + E E + A M +A+ L+D + + ELL M+ K K++ +S
Sbjct: 767 KKVANLKHKEQVEKKKSAQMLEEARRREDSLSDSSQQLQVEELLMAME----KVKQELES 822
Query: 342 RRDIIDRVAEWKSAAEEEKWL 362
+ + + S AE+E L
Sbjct: 823 MKAKLSSTQQ--SLAEKETHL 841
>CENF_HUMAN (P49454) CENP-F kinetochore protein (Centromere protein F)
(Mitosin) (AH antigen)
Length = 3210
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/322 (21%), Positives = 134/322 (40%), Gaps = 39/322 (12%)
Query: 4 QIEQEYSEIYHRK-----VEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGT 58
++E E +EI K +ED++K L++ L + E+++I S + ++ GT
Sbjct: 919 KVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978
Query: 59 LKQ-------QLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQD 111
LK+ + N+I E ER K I E+ Q Q + + G +D
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYED 1038
Query: 112 VDQ-CDLTMEKLGKLKSHLNE----LQNEKN----------IRHQKVKSHISTISELSAV 156
+ Q EK KL+ LNE +N KN HQ+ + ++ E +
Sbjct: 1039 LSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQN 1098
Query: 157 MSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKV-QFLEEL 215
+ +++ + + + D+ N ++ L + ++ LK+E+ + ++V L+E
Sbjct: 1099 LMLELETVQQALRSEMTDNQNNSKSEAGG-----LKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 216 WDFMGITTDEQKAVCDDVIG-LISASVDEVSIHGSLSNDIVKQVDVEVQRLQV--LNPSK 272
M + + K C ++ I SV E + N Q+D+EV+ + + N
Sbjct: 1154 EQLMKVM--KTKHECQNLESEPIRNSVKERESERNQCN-FKPQMDLEVKEISLDSYNAQL 1210
Query: 273 MKEFVFKRQKELAFKRQNELEE 294
++ R KEL + + +E
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKE 1232
Score = 41.6 bits (96), Expect = 0.004
Identities = 74/337 (21%), Positives = 147/337 (42%), Gaps = 44/337 (13%)
Query: 59 LKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGV----TDQDVDQ 114
L+ + +I VED + K +++ +EI +K+QI + Q +G +Q+++
Sbjct: 2595 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2654
Query: 115 CDLTME----------KLGKLKSHLNELQNE-KNIRHQKVKSHISTISELSAV--MSIDI 161
+LT+E K L+ L LQ+ KN+ ++ + + +S + V M+
Sbjct: 2655 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2714
Query: 162 SEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQF------LEEL 215
+E+ +H ++ Q+ +S E E LLL++ K Q + L++
Sbjct: 2715 TELQREMHEMAQKTAE-LQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2773
Query: 216 WDFMGITTDEQKAVCDDVIGLISASVDEV-SIHGSLSNDIVKQVDVEVQRLQVLNPSKMK 274
D M E++ + I + E H +L D KQ +VE+Q + SK +
Sbjct: 2774 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK-E 2832
Query: 275 EFVFKRQKELAFKRQNELEEIHRGAHMDMDAKAARQILTDL----IGNIDM-------SE 323
E + ++ E+ + ++ E ++ KA QIL +L + N+ +E
Sbjct: 2833 ECLSSQKLEIDLLKSSKEE-------LNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2885
Query: 324 LLQGMDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEEK 360
QG K + K+ +Q + ++I+ + AA+E++
Sbjct: 2886 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2922
Score = 33.9 bits (76), Expect = 0.82
Identities = 70/401 (17%), Positives = 165/401 (40%), Gaps = 51/401 (12%)
Query: 8 EYSEIYHRKVEDTIKHKDYLNKVLD---------DFQSEIANIASSLGEDYVSFSRGKGT 58
EY H+++ ++ + LN L+ D +A + S E ++
Sbjct: 1943 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 2002
Query: 59 LKQQLANI----IPVVEDLRFKKKERV----------KEILEIKSQISQIRAEKAGCGQS 104
++ + A+I + + DL + E++ K I+ ++ ++S + +E+
Sbjct: 2003 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 2062
Query: 105 KGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEI 164
+ D EK+ + L Q+E Q ++ + +EL +S D+SE+
Sbjct: 2063 LDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL 2122
Query: 165 LNG---IHPSLNDSSNGAQ-----QSISDETLARLNESVLLLKQEKQQSLQKVQFLEELW 216
L + L +Q + + +A+LN+ LL +E +SLQ + E +
Sbjct: 2123 LKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKE-SESLQ-ARLSESDY 2180
Query: 217 DFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVK-QVDVEVQRLQVLNPSK--- 272
+ + ++ + A+ + + S + +H L I K +V +E + L+ ++
Sbjct: 2181 EKLNVSKALEAALVEKGEFALRLSSTQEEVH-QLRRGIEKLRVRIEADEKKQLHIAEKLK 2239
Query: 273 --------MKEFVFKRQKELAFKRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSEL 324
+K+ V ++EL +N+ I + + + + + ++ ++ + EL
Sbjct: 2240 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2299
Query: 325 ----LQGMDKQIRKAKEQAQSRRDIIDR-VAEWKSAAEEEK 360
L+ + + K ++ Q + +D+ ++ +KS EE++
Sbjct: 2300 DLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2340
>MYSN_ACACA (P05659) Myosin II heavy chain, non muscle
Length = 1509
Score = 49.3 bits (116), Expect = 2e-05
Identities = 83/398 (20%), Positives = 172/398 (42%), Gaps = 63/398 (15%)
Query: 4 QIEQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIA----------NIASSLGEDYVSFS 53
++E E +E+ K ED D L K +D E+ NI+ +L +
Sbjct: 979 KVESERNELQD-KYEDEAAAHDSLKKKEEDLSRELRETKDALADAENISETLRSKLKNTE 1037
Query: 54 RGKGTLKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVD 113
RG ++ +L ++ L KK +E+ + ++Q+ + EK+G + Q
Sbjct: 1038 RGADDVRNELDDVTATKLQLEKTKKSLEEELAQTRAQLEE---EKSGKEAASSKAKQLGQ 1094
Query: 114 QCDLTMEKLGKLKSHLN------------------ELQNEKNIRHQKVKSHISTISELSA 155
Q + ++ LKS L+ +L++E+ +R K + ++L+
Sbjct: 1095 QLEDARSEVDSLKSKLSAAEKSLKTAKDQNRDLDEQLEDERTVRANVDKQKKALEAKLT- 1153
Query: 156 VMSIDISEILNGIHPSLNDSSNGAQ--QSISDETLARLNE---SVLLLKQEKQQSLQKVQ 210
++ + + + N ++ A+ ++ DET RL E S L++E++ +L +V
Sbjct: 1154 ----ELEDQVTALDGQKNAAAAQAKTLKTQVDETKRRLEEAEASAARLEKERKNALDEVA 1209
Query: 211 FLEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNP 270
L D + +Q+ + I + + ++ G S++ VK+++ E++RL+
Sbjct: 1210 QLTADLDAERDSGAQQRRKLNTRISELQSELENAPKTGGASSEEVKRLEGELERLE---- 1265
Query: 271 SKMKEFVFKRQKELAFKRQN------ELEEIHRGAHMDMDAKAARQILTD---LIGNIDM 321
E + Q+ A +N ELEE+ + A D A+ +++ D L ++D
Sbjct: 1266 ----EELLTAQEARAAAEKNLDKANLELEELRQEA--DDAARDNDKLVKDNRKLKADLDE 1319
Query: 322 SELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEE 359
+ +Q ++Q K+ + SRR ++ + E K +E
Sbjct: 1320 AR-IQLEEEQDAKSHADSSSRR-LLAEIEELKKRVAKE 1355
>ERC1_MOUSE (Q99MI1) ERC protein 1 (Rab6-interacting protein 2)
(Rab6IP2) (CAZ-associated structural protein 2) (CAST2)
Length = 1120
Score = 49.3 bits (116), Expect = 2e-05
Identities = 65/306 (21%), Positives = 133/306 (43%), Gaps = 47/306 (15%)
Query: 58 TLKQQLANIIPV-VEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCD 116
T K+Q A I+ V+ LR + +E+ + + QI + EK G G D D
Sbjct: 511 TAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK---GTQAGEIHDLKDMLD 567
Query: 117 LTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSS 176
+ K+ L+ + LQ + + +++ S + L A + + L + +L D
Sbjct: 568 VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT-NTDTALTTLEEALADK- 625
Query: 177 NGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGL 236
+ T+ RL E ++EKQ+ + + ++L D E+ ++ +
Sbjct: 626 --------ERTIERLKEQRDRDEREKQEEIDT--YKKDLKDLR-----EKVSLLQGDLSE 670
Query: 237 ISASVDEVSIHGS--LSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEE 294
AS+ ++ H S S+ + K RL+ L E +++KE K +++L++
Sbjct: 671 KEASLLDIKEHASSLASSGLKKD-----SRLKTL------EIALEQKKEECLKMESQLKK 719
Query: 295 IHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKS 354
H ++A+A+ + MS+ +Q ++++I + K+++ + +DR+ E
Sbjct: 720 AHEAT---LEARASPE----------MSDRIQQLEREISRYKDESSKAQTEVDRLLEILK 766
Query: 355 AAEEEK 360
E EK
Sbjct: 767 EVENEK 772
>C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 190)
(Microtubule binding protein 190) (d-CLIP-190)
Length = 1690
Score = 49.3 bits (116), Expect = 2e-05
Identities = 88/402 (21%), Positives = 174/402 (42%), Gaps = 54/402 (13%)
Query: 5 IEQEYSEIYHRKVE--DTIKHKDYLNKVLDDFQ--SEIANIASSLGEDYVS-FSRGKGTL 59
+E+ E+ K + T+ K+ L K + D + +E + + E+ ++ K ++
Sbjct: 673 LEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESI 732
Query: 60 KQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTM 119
+QQLA +ED + K+ E + EIK+Q +Q E G+S Q ++Q L
Sbjct: 733 EQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGH 792
Query: 120 EKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGA 179
E KL++ L EL+ EK ++ + + + SA + + + ++
Sbjct: 793 E---KLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASG 849
Query: 180 QQSISDETLARLNESVLLLK---QEKQQSLQKVQF-----LEELWDFMGITTDEQKA--- 228
++ +T+A+L++ + LK +E Q L+ Q ++L G +E K
Sbjct: 850 EE--GSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGH 907
Query: 229 VCDDVIGLISASVDEVSIHGSLSNDI---VKQVDVEVQRLQVLNPSKMKEFVFKRQKELA 285
+ + + L S + + S D+ KQ++ L+ +N KE+ R + A
Sbjct: 908 LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVN----KEYAESRAE--A 961
Query: 286 FKRQNELEEIHRGAHMDMDA-------------KAARQILT---DLIGNID--MSELLQG 327
Q++++EI H ++ A K + +I T +L D E+LQ
Sbjct: 962 SDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQ- 1020
Query: 328 MDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEEKWLDEYERFI 369
+K++++ ++Q Q +D ++ K AE E+ +E I
Sbjct: 1021 KEKELQELRQQLQDSQD-----SQTKLKAEGERKEKSFEESI 1057
Score = 34.3 bits (77), Expect = 0.63
Identities = 68/337 (20%), Positives = 152/337 (44%), Gaps = 46/337 (13%)
Query: 59 LKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLT 118
L +++ I +++ + ER K+ E++ ++ Q + + Q + +
Sbjct: 1166 LIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQ----------ESQTS 1215
Query: 119 MEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNG 178
EKL +++ L ELQ+ + + V++ + E S+++ ++ LN + L + ++
Sbjct: 1216 KEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTK-LNESNVQLENKTSC 1274
Query: 179 AQQS-----ISDETLARLNESVLLLKQEKQQ----------SLQKVQ----FLEELWDFM 219
+++ S + +L E L E QQ SL KV+ LEE
Sbjct: 1275 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAA 1334
Query: 220 GITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFK 279
D Q+A ++ L+ S + G+L + + V ++Q+L+ N ++KE + +
Sbjct: 1335 TSQLDAQQATNKELQELLVKSQEN---EGNLQGESL-AVTEKLQQLEQAN-GELKEALCQ 1389
Query: 280 RQ---KELAFK--RQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRK 334
++ KEL K N + E + +H ++ K + + + S+L + + Q+++
Sbjct: 1390 KENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL-SQLKQ 1448
Query: 335 AKEQ----AQSRRDIIDRVAEWKS-AAEEEKWLDEYE 366
A E+ Q ++ ++++ E+ + AE +K +DE +
Sbjct: 1449 ANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMD 1485
>PLE1_CRIGR (Q9JI55) Plectin 1 (PLTN) (PCN) (300-kDa intermediate
filament-associated protein) (IFAP300) (Fragment)
Length = 4473
Score = 48.5 bits (114), Expect = 3e-05
Identities = 80/390 (20%), Positives = 174/390 (44%), Gaps = 44/390 (11%)
Query: 54 RGKGTLKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVD 113
R K ++Q+L + L+ ++ + K IL+ ++ +++AE + + ++++
Sbjct: 2105 RQKAQVEQELTTL-----RLQLEETDHQKSILD--EELQRLKAEVTEAARQRSQVEEELF 2157
Query: 114 QCDLTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLN 173
+ ME+LGKLK+ + E +N I K + E A ++E + +
Sbjct: 2158 SVRVQMEELGKLKARI-EAENRALILRD--KDNTQRFLEEEAEKMKQVAEEAARLSVAAQ 2214
Query: 174 DSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFL----EELWDFMGITTDEQKAV 229
+++ Q +++E LA+ + +EK Q++Q+ L E L + ++ + +
Sbjct: 2215 EAARLRQ--LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2272
Query: 230 CDDVIGLISASVDEV-SIHGSLSNDIVKQVDV--EVQRLQVLNPSKMKEFVFKRQKELAF 286
+D + V+E +L + +Q+++ E +RL+ L ++M R +E A
Sbjct: 2273 QEDKEQMAQQLVEETQGFQRTLEVERQRQLEMSAEAERLK-LRMAEMSR-AQARAEEDAQ 2330
Query: 287 KRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDM--------SELLQGMDKQIRKAKEQ 338
+ + + EEI H + A Q L+ +++ +E L+ ++ + KE+
Sbjct: 2331 RFRKQAEEIGEKLHR---TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2387
Query: 339 AQSRRDIIDRVAEWKSAAEEEKWLDEYERFI*SVRRKRGFLSPRFHLW*RI*LQK*KHGR 398
+ ++ +E ++E+ L E + ++ FLS + L LQ+ +
Sbjct: 2388 LKQEAKLLQLKSEEMQTVQQEQILQETQAL------QKSFLSEKDSL-----LQRERFIE 2436
Query: 399 QTKKKVSYMKSLHEYNVQRQLREEEKRKSR 428
Q K K+ + E +QLREE++R+ R
Sbjct: 2437 QEKAKLEQLFQ-DEVAKAQQLREEQQRQQR 2465
Score = 32.7 bits (73), Expect = 1.8
Identities = 36/180 (20%), Positives = 79/180 (43%), Gaps = 11/180 (6%)
Query: 188 LARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIH 247
L R+ S + K+Q+ Q+ +L ++++ ++ + A+ +E +
Sbjct: 1874 LGRIRSSAEDTMRSKEQAEQEAARQRQL----AAEEEQRRREAEERVQKSLAAEEEAARQ 1929
Query: 248 GSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEEIHRGAHMDMDAKA 307
+ + V+++ +V+ + L +E RQ +LA + + + AH + +
Sbjct: 1930 RKAALEEVERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFVVQQR 1987
Query: 308 ARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEEKWLDEYER 367
++ L M E L+G + R+A E+A+ R+ +R AA+ K ++E ER
Sbjct: 1988 EEELQQTLQQEQSMLERLRGEAEAARRAAEEAEEAREQAER-----EAAQSRKQVEEAER 2042
>MYSS_RABIT (P02562) Myosin heavy chain, skeletal muscle (Fragments)
Length = 1084
Score = 48.5 bits (114), Expect = 3e-05
Identities = 79/398 (19%), Positives = 167/398 (41%), Gaps = 51/398 (12%)
Query: 13 YHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVED 72
+ K E+T + K +E+ + ++ E TLK++ N+ + D
Sbjct: 605 WKHKYEETQAELEASQKESRSLSTEVFKVKNAYEESLDHLE----TLKRENKNLQQEISD 660
Query: 73 LRFKKKERVKEILE---IKSQISQIRAE-KAGCGQSKGVTDQDVDQCDLTMEKLGKLKSH 128
L + E K I E +K QI Q ++E +A +++G + + + +L ++KS
Sbjct: 661 LTEQIAESAKHIHELEKVKKQIDQEKSELQAALEEAEGSLEHEEGKILRIQLELNQVKSE 720
Query: 129 LNELQNEKNIRHQKVK-SHISTISELSAVMSIDISE-------------ILNGIHPSLND 174
++ EK+ ++K +H+ + + + + +I LN + LN
Sbjct: 721 IDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNH 780
Query: 175 SSNGAQQSISD---------ETLARLNESV--------LLLKQEKQQSLQKVQFLEELWD 217
++ A ++I + +T L+++V L E++ +L + + +EEL
Sbjct: 781 ANRQAAEAIKNLRNTQGILKDTQLHLDDAVRGQDDHKEQLAMVERRANLMQAE-IEELRA 839
Query: 218 FMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQ------VLNPS 271
+ T+ + V D + S V + + + K+++ ++ ++Q V
Sbjct: 840 SLE-QTERSRRVADQDLLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 898
Query: 272 KMKEFVFKRQKELAFKRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSE--LLQGMD 329
+E K + A + +E AH++ K Q + DL +D +E L+G
Sbjct: 899 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQQRLDEAEQLALKGGK 958
Query: 330 KQIRKAKEQAQSRRDIIDRVAEWKSAAEEEKWLDEYER 367
KQI+K + + + + ++ +E K E K L ++ER
Sbjct: 959 KQIQKLEARVKELENEVE--SEQKRNVEAVKGLRKHER 994
Score = 43.1 bits (100), Expect = 0.001
Identities = 96/489 (19%), Positives = 192/489 (38%), Gaps = 83/489 (16%)
Query: 2 LLQIEQEYSEIYHRKVEDTIKHKDYLNKVL------DDFQSEIANIASSLG--EDYVSFS 53
+ +++E+ + + K K+ K++ +D Q ++ A SL E+
Sbjct: 8 MANMKEEFEKTKESLAKAEAKRKELEEKMVALMQEKNDLQLQVQAEADSLADAEERQDLI 67
Query: 54 RGKGTLKQQLANIIPVVED-------LRFKKKERVKEILEIKSQISQIRAEKAGCGQSKG 106
+ K L+ ++ + ED L KK++ E E+K I + A + K
Sbjct: 68 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 127
Query: 107 VTDQDVDQ-------CDLTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSI 159
T+ V D T+ KL K K L E + Q + ++T+++ +
Sbjct: 128 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQ 187
Query: 160 DISEILNGIHPSLN---DSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELW 216
+ ++ + D ++ D LA+ E+ + ++ +KQQ +K++ LE +
Sbjct: 188 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ--ETSMDIENDKQQLDEKLKKLEFMT 245
Query: 217 DFMGITTDEQKAV-----CDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPS 271
+ DEQ + +++ I A + +D+ ++++ +RL+ +
Sbjct: 246 NLQSKIEDEQALMTNLQRIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 305
Query: 272 KMKEFVFKRQKELAF-KRQNELEEIH----------RGAHMDMDAKAARQILTDLIGNI- 319
+ +++E F K + +LEE R H D A+ QI D + +
Sbjct: 306 TSAQIEMNKKREAEFEKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI--DNLQRVK 363
Query: 320 -----DMSEL------LQGMDKQIRKAKEQAQSR-RDIIDRVAEWKSAAEEEKWLDEYER 367
+ SEL L G + + KAK + R + D+++E K+ E E++R
Sbjct: 364 QKLEKEKSELKMEIDDLAGNMETVSKAKGNLEKMCRTLEDQLSEVKTKEE------EHQR 417
Query: 368 FI*SVRRKRGFLSPRFHLW*RI*LQK*KHGRQTKKKVSYMKSLHE---------YNVQRQ 418
I + ++ R+ + + RQ +K + + L ++RQ
Sbjct: 418 LINELSAQKA----------RLHTESGEFSRQLDEKDAMVSQLSRGGQAFTQQIEGLKRQ 467
Query: 419 LREEEKRKS 427
L EE K KS
Sbjct: 468 LEEETKAKS 476
>ERC1_HUMAN (Q8IUD2) ERC protein 1 (ELKS protein)
Length = 1116
Score = 48.5 bits (114), Expect = 3e-05
Identities = 65/306 (21%), Positives = 134/306 (43%), Gaps = 47/306 (15%)
Query: 58 TLKQQLANIIPV-VEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCD 116
T K+Q A I+ V+ LR + +E+ + + QI + EK G G D D
Sbjct: 511 TAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK---GTQAGEIHDLKDMLD 567
Query: 117 LTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSS 176
+ K+ L+ + LQ + + +++ S + L A + + L + +L +
Sbjct: 568 VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT-NTDTALTTLEEALAEK- 625
Query: 177 NGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGL 236
+ T+ RL E ++EKQ+ + + ++L D E+ ++ +
Sbjct: 626 --------ERTIERLKEQRDRDEREKQEEIDN--YKKDLKDLK-----EKVSLLQGDLSE 670
Query: 237 ISASVDEVSIHGS--LSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELEE 294
AS+ ++ H S S+ + K RL+ L E +++KE K +++L++
Sbjct: 671 KEASLLDLKEHASSLASSGLKKD-----SRLKTL------EIALEQKKEECLKMESQLKK 719
Query: 295 IHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDIIDRVAEWKS 354
H A ++A+A+ + MS+ +Q ++++I + K+++ + +DR+ E
Sbjct: 720 AHEAA---LEARASPE----------MSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 766
Query: 355 AAEEEK 360
E EK
Sbjct: 767 EVENEK 772
>GCC2_MOUSE (Q8CHG3) GRIP and coiled-coil domain-containing protein 2
(Golgi coiled coil protein GCC185)
Length = 1679
Score = 48.1 bits (113), Expect = 4e-05
Identities = 62/313 (19%), Positives = 131/313 (41%), Gaps = 53/313 (16%)
Query: 51 SFSRGKGTLKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQ 110
+F R L +QL N E L ++ + I +++ + A+ ++KGV ++
Sbjct: 1033 NFERHIEDLTKQLRNSTCQYERLTSDNEDLLARIETLQANAKLLEAQILEVQKAKGVVEK 1092
Query: 111 DVDQCDLTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHP 170
++D ELQ E QK+K H+ST++EL + + + +
Sbjct: 1093 ELDA---------------EELQKE-----QKIKEHVSTVNELEE-LQLQFQKEKKQLQK 1131
Query: 171 SLND----SSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQ 226
++ + + Q ++ + +A L+K+ Q+ K +E+L M I ++Q
Sbjct: 1132 TMQELELVKKDAQQTTLMNMEIADYER---LMKELNQKLTNKNSTIEDLEQEMKIQKEKQ 1188
Query: 227 KAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAF 286
+ + +++ L S+ VQ + N +K+K+ + K +KELA
Sbjct: 1189 ETLQEEITSLQSS----------------------VQHYEEKN-TKIKQLLVKTKKELAD 1225
Query: 287 KRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDII 346
+Q E + + A + + +A++Q + + I ++E+ K K A+ + +
Sbjct: 1226 AKQAETDHLLLQASLKGELEASQQQVE--VYKIQLAEMTSEKHKIHEHLKTSAEQHQRTL 1283
Query: 347 DRVAEWKSAAEEE 359
+ A +EE
Sbjct: 1284 SAYQQRVVALQEE 1296
>RA50_YEAST (P12753) DNA repair protein RAD50 (153 kDa protein)
Length = 1312
Score = 46.6 bits (109), Expect = 1e-04
Identities = 69/327 (21%), Positives = 144/327 (43%), Gaps = 26/327 (7%)
Query: 25 DYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRFKKKERVKEI 84
D K L+ + E S L E V ++ K + + I P++E + +KE +K++
Sbjct: 751 DNSQKCLEKAKEETKTSKSKLDELEVDSTKLKDEKELAESEIRPLIEKFTYLEKE-LKDL 809
Query: 85 LEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKNIRHQKVK 144
IS+ + D+ DQ + L +L+ +++LQ EK+ + ++
Sbjct: 810 ENSSKTISEELSIYNTSEDGIQTVDELRDQQRKMNDSLRELRKTISDLQMEKDEKVRENS 869
Query: 145 SHISTISELSAVMSIDISEILNGI--HPSLNDSSNGAQQSIS--DETLARLNESVLLLKQ 200
I+ I E + +SEI + + +++DS +++I+ D + L ++ LK
Sbjct: 870 RMINLIKE----KELTVSEIESSLTQKQNIDDSIRSKRENINDIDSRVKELEARIISLKN 925
Query: 201 EKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDV 260
+K ++ + ++ D ++QK V D I+ +D ++ N++ VD
Sbjct: 926 KKDEAQSVLDKVKNERDIQ--VRNKQKTVAD-----INRLIDRFQ---TIYNEV---VDF 972
Query: 261 EVQRLQVLNPSKMKEFVFKRQKELAFKRQNELE--EIHRGAHMDMDAKAARQILTDLIGN 318
E + L + +KE + + L K Q +L+ E++ D+ + L +
Sbjct: 973 EAKGFDELQ-TTIKELELNKAQMLELKEQLDLKSNEVNEEKRKLADSNNEEKNLKQNLEL 1031
Query: 319 IDMSELLQGMDKQIRKAKEQ-AQSRRD 344
I++ LQ ++ +I + Q A++ RD
Sbjct: 1032 IELKSQLQHIESEISRLDVQNAEAERD 1058
Score = 32.3 bits (72), Expect = 2.4
Identities = 47/264 (17%), Positives = 102/264 (37%), Gaps = 38/264 (14%)
Query: 27 LNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRFKKKERVKEILE 86
L +D + E++ I S L E I D FK + ++IL
Sbjct: 229 LQTKIDQYNEEVSEIESQLNE-------------------ITEKSDKLFKSNQDFQKIL- 268
Query: 87 IKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKNIRHQKVKSH 146
S++ ++ K +D DL+ L L ++ +++ +KN + + +++
Sbjct: 269 --SKVENLKNTKLSISDQVKRLSNSIDILDLSKPDLQNLLANFSKVLMDKNNQLRDLETD 326
Query: 147 ISTISE-LSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQEKQQS 205
IS++ + S++ S+ S I + ET + + LK+ Q
Sbjct: 327 ISSLKDRQSSLQSLSNSLI-----------RRQGELEAGKETYEKNRNHLSSLKEAFQHK 375
Query: 206 LQKVQFLE--ELWDFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQ 263
Q + +E ++ + + + D+ I ++ + + +D++K + V+ Q
Sbjct: 376 FQGLSNIENSDMAQVNHEMSQFKAFISQDLTDTIDQFAKDIQLKETNLSDLIKSITVDSQ 435
Query: 264 RLQVLNPSKMKEFVFKRQKELAFK 287
L+ + K + +ELA K
Sbjct: 436 NLEYNKKDRSK--LIHDSEELAEK 457
Score = 30.8 bits (68), Expect = 7.0
Identities = 40/229 (17%), Positives = 91/229 (39%), Gaps = 29/229 (12%)
Query: 27 LNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRFKKKE------- 79
+N+++D FQ+ + + + L+ A ++ + E L K E
Sbjct: 955 INRLIDRFQTIYNEVVDFEAKGFDELQTTIKELELNKAQMLELKEQLDLKSNEVNEEKRK 1014
Query: 80 ------------RVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKS 127
+ E++E+KSQ+ I +E + ++D Q E+ +L++
Sbjct: 1015 LADSNNEEKNLKQNLELIELKSQLQHIESEISRLDVQNAEAERDKYQ-----EESLRLRT 1069
Query: 128 HLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDET 187
+L +E + ++K + I L+ + D +I H + + + +
Sbjct: 1070 RFEKLSSENAGKLGEMKQLQNQIDSLTHQLRTDYKDIEKNYHKEWVELQTRSFVTDDIDV 1129
Query: 188 LAR-LNESVLLLKQEKQQSLQKVQFLEELW--DFMGITTDEQKAVCDDV 233
++ L+ +++ K Q + ++ ++ELW + G D K D+V
Sbjct: 1130 YSKALDSAIMKYHGLKMQDINRI--IDELWKRTYSGTDIDTIKIRSDEV 1176
Score = 30.4 bits (67), Expect = 9.1
Identities = 81/380 (21%), Positives = 151/380 (39%), Gaps = 53/380 (13%)
Query: 13 YHRKVEDTIKH-KDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQ-QLANIIPVV 70
Y++K + H + L + L F+S + SL + + K L+ + NIIP
Sbjct: 439 YNKKDRSKLIHDSEELAEKLKSFKS--LSTQDSLNHELENLKTYKEKLQSWESENIIP-- 494
Query: 71 EDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLN 130
L K +E+ E++ +++QI + + Q Q DL KLG +K +N
Sbjct: 495 -KLNQKIEEKNNEMIILENQIEKFQDRIMKTNQ----------QADL-YAKLGLIKKSIN 542
Query: 131 ----ELQN--EKNIRHQKVKSHISTISELS-AVMSIDISEILNGIHPSLNDSSNGAQQSI 183
ELQ EK +++ E A + +D ++ + ++ ++ +
Sbjct: 543 TKLDELQKITEKLQNDSRIRQVFPLTQEFQRADLEMDFQKLFINMQKNIAINNKKMHELD 602
Query: 184 SDETLARLNESVLLLK-QEKQQSLQKV-QFLEELWDFMGITTDEQKAVCDDVIGLISASV 241
T A N + + Q+ Q+S +KV Q L E T DE V ++ ++
Sbjct: 603 RRYTNALYNLNTIEKDLQDNQKSKEKVIQLLSENLP-EDCTIDEYNDVLEETELSYKTAL 661
Query: 242 DEVSIHGSLSNDIVKQVDV-EVQRLQVLNPSKMKEFVFKR--------------QKELAF 286
+ + +H + K +++ E L K + FK +K L
Sbjct: 662 ENLKMHQTTLEFNRKALEIAERDSCCYLCSRKFENESFKSKLLQELKTKTDANFEKTLKD 721
Query: 287 KRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQAQSRRDII 346
QNE E +H + R + +I ++E + K + KAKE+ ++ + +
Sbjct: 722 TVQNEKEYLH----------SLRLLEKHIITLNSINEKIDNSQKCLEKAKEETKTSKSKL 771
Query: 347 DRVAEWKSAAEEEKWLDEYE 366
D + + ++EK L E E
Sbjct: 772 DELEVDSTKLKDEKELAESE 791
>MYSN_DROME (Q99323) Myosin heavy chain, non-muscle (Zipper protein)
(Myosin II) (Non-muscle MHC)
Length = 2057
Score = 46.6 bits (109), Expect = 1e-04
Identities = 66/363 (18%), Positives = 145/363 (39%), Gaps = 69/363 (19%)
Query: 6 EQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANI---ASSLGEDYVSFSRGKGTLKQQ 62
EQE + + E+T+ H+ L + E+ +I +L + + KGTL+ +
Sbjct: 1257 EQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAE 1316
Query: 63 LANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKL 122
A++ + + ++E + + +SQI++++ + A +++ EK
Sbjct: 1317 NADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSE----------LQEKC 1366
Query: 123 GKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQS 182
KL+ + N+ K + + + S + + ++ AQQ
Sbjct: 1367 TKLQQEAENITNQLEEAELKASAAVKSASNMESQLT-------------------EAQQL 1407
Query: 183 ISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVD 242
+ +ET +L S L + E ++ + Q E+ DE K + + ++ +
Sbjct: 1408 LEEETRQKLGLSSKLRQIESEKEALQEQLEED---------DEAKRNYERKLAEVTTQMQ 1458
Query: 243 EVSIHGSLSNDIVKQV---------DVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNELE 293
E+ D+ K++ D+E QV + + K +K++ Q+ELE
Sbjct: 1459 EIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKI----QSELE 1514
Query: 294 EIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAK---EQAQSRRDIIDRVA 350
+ A ++++A+ + +++ + + DK + + K EQ RD +R A
Sbjct: 1515 D----ATIELEAQRTKV--------LELEKKQKNFDKILAEEKAISEQIAQERDTAEREA 1562
Query: 351 EWK 353
K
Sbjct: 1563 REK 1565
Score = 39.3 bits (90), Expect = 0.020
Identities = 73/405 (18%), Positives = 158/405 (38%), Gaps = 74/405 (18%)
Query: 2 LLQIEQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQ 61
+L + +E E + K+ED + L LDD +AN + ++ + K L+
Sbjct: 1569 VLSVSRELDEAFD-KIEDLENKRKTLQNELDD----LANTQGTADKNVHELEKAKRALES 1623
Query: 62 QLANI----------IPVVEDLRF--------------------------KKKERVKEIL 85
QLA + + + ED + K++ VK++
Sbjct: 1624 QLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLR 1683
Query: 86 EIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKNIRHQKVKS 145
++++++ + R ++ SK + D+ + + TME K+K + L++ K ++ Q VK
Sbjct: 1684 DLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKE--DALKHAKKLQAQ-VKD 1740
Query: 146 HISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQEKQQS 205
+ E A E L +L+ ++G +++ E L + + +
Sbjct: 1741 ALRDAEEAKAA-----KEELQ----ALSKEADGKVKALEAEVLQLTEDLASSERARRAAE 1791
Query: 206 LQKVQFLEELWD--FMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQ 263
++ + EE+ + G ++K + I + ++E + + D ++ ++++
Sbjct: 1792 TERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIE 1851
Query: 264 RLQVLNPSKMKEFVFKRQKELAFKRQN-----ELEEIH-------RGAHMDMDAKAARQI 311
+L ++ +RQN +L EI + ++AK A
Sbjct: 1852 QLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIAN-- 1909
Query: 312 LTDLIGNIDMSELLQ-----GMDKQIRKAKEQAQSRRDIIDRVAE 351
L + + N LLQ MDK+I++ + R +D+ E
Sbjct: 1910 LEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKE 1954
>M18A_HUMAN (Q92614) Myosin XVIIIA (Myosin 18A) (Myosin containing PDZ
domain)
Length = 2054
Score = 46.6 bits (109), Expect = 1e-04
Identities = 76/383 (19%), Positives = 166/383 (42%), Gaps = 50/383 (13%)
Query: 1 MLLQIEQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGE-DYVSFSRGKGTL 59
M +Q+E+EY + K + + + + ++A ++ + D+ S R + L
Sbjct: 1611 MEVQLEEEYED------------KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDL 1658
Query: 60 KQQ---LANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCD 116
K+ LA+ +++ L+ + +EI ++K+Q+ + A +++ + +++
Sbjct: 1659 KRTKALLADAQLMLDHLKNSAPSK-REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLH 1717
Query: 117 LTMEKLGKLKSHLNE----LQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSL 172
L ++ + K K+ L E LQ EKN ++++ + E D++E++ ++
Sbjct: 1718 LQIDDIAKAKTALEEQLSRLQREKN----EIQNRLEEDQE-------DMNELMKKHKAAV 1766
Query: 173 NDSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDD 232
+S Q ++ A+L E+ +EKQ+ +K+Q L+ +F+ EQ V
Sbjct: 1767 AQASRDLAQ--INDLQAQLEEA----NKEKQELQEKLQALQSQVEFL-----EQSMVDKS 1815
Query: 233 VIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNEL 292
++ A + E+ VK+++ RL+ M++ +R + +A + + E
Sbjct: 1816 LVSRQEAKIRELETRLEFERTQVKRLESLASRLK----ENMEKLTEERDQRIAAENR-EK 1870
Query: 293 EEIHRGAHMDMDAKAARQILTDLIGNIDMSELLQGMDKQIRKAKEQA--QSRRDIIDRVA 350
E+ R D K L + MD + +A Q+ + R+
Sbjct: 1871 EQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIG 1930
Query: 351 EWKSAAEEEKWLDEYERFI*SVR 373
+ ++A E+E DE E I S++
Sbjct: 1931 DLQAAIEDEMESDENEDLINSLQ 1953
>MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 46.2 bits (108), Expect = 2e-04
Identities = 84/410 (20%), Positives = 179/410 (43%), Gaps = 70/410 (17%)
Query: 3 LQIEQEYSEIYHRKVEDTIKHKDYLNKVLDD----FQSEIANIASSLGEDYVSFSRGKGT 58
LQ+E+ +E +K+ED I D N L + I+++ ++L E+ ++
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK-AKNLTK 1027
Query: 59 LKQQLANIIPVVEDLRFKKKERVKEILE-------------------IKSQISQIRAEKA 99
LK + ++I +E +R KK+E+ ++ LE +++QI++++ + A
Sbjct: 1028 LKNKHESMISELE-VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 100 GCGQSKGVT----DQDVDQCDLTMEKLGKLKSHLNELQ----NEKNIRHQKVKSHISTIS 151
+ D ++ Q + ++K+ +L+ H+++LQ +E+ R++ K
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 152 ELSAVM-----SIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLLLKQEKQQSL 206
EL A+ ++D + + ++++ +ET + V ++Q+ Q++
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAV 1205
Query: 207 QKVQFLEELWDFMGITTDEQKAVCD----DVIGLISASVDEVSIHGSLSNDI---VKQVD 259
+++ E + D+ K + D+ G E+ + G ++ K+++
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAG-------ELRVLGQAKQEVEHKKKKLE 1258
Query: 260 VEVQRLQVLNPSKMKEFVFKRQK--ELAFKRQNELEEIHRGAHMDMDAKA---ARQILTD 314
+VQ LQ SK + R + + K QNE+E + G + + KA A+ + +
Sbjct: 1259 AQVQELQ----SKCSDGERARAELNDKVHKLQNEVESV-TGMLNEAEGKAIKLAKDVASL 1313
Query: 315 LIGNIDMSELLQGMDKQ-------IRKAKEQAQSRRDIIDRVAEWKSAAE 357
D ELLQ +Q +R+ +E+ S +D +D E K E
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/311 (19%), Positives = 128/311 (40%), Gaps = 48/311 (15%)
Query: 70 VEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHL 129
V+++R K + V+E+ E Q+ Q + KA ++K +++ + LG+ K +
Sbjct: 1194 VQEMRQKHAQAVEELTE---QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 130 NELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHP------------------- 170
+ + + Q+++S S A ++ + ++ N +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 171 -SLNDSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAV 229
SL+ Q+ + +ET +LN S L + E++++ + Q EE+ E K
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM---------EAKQN 1361
Query: 230 CDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQ 289
+ I ++ + +D K++ ++ L K K F QKE+ Q
Sbjct: 1362 LERHISTLNIQL----------SDSKKKLQDFASTVEALEEGK-KRF----QKEIENLTQ 1406
Query: 290 NELEEIHRGAHMDMDAKAARQILTDLIGNID-MSELLQGMDKQIRKAKEQAQSRRDIIDR 348
E+ ++ +Q L DL+ ++D +L+ ++K+ RK + ++I +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 349 VAEWKSAAEEE 359
A+ + AE E
Sbjct: 1467 YADERDRAEAE 1477
Score = 41.2 bits (95), Expect = 0.005
Identities = 71/355 (20%), Positives = 140/355 (39%), Gaps = 51/355 (14%)
Query: 18 EDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRFKK 77
E+ IK L + DFQ E+ + +S E + + + K A+++ + EDL +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 78 KERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNEKN 137
+ R + LE K +++ E+L S N LQ+EK
Sbjct: 1701 RARKQADLE-KEELA---------------------------EELASSLSGRNALQDEK- 1731
Query: 138 IRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESVLL 197
+++++ I+ + E ++ + + + + + + + ++ + A+ NES
Sbjct: 1732 ---RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA-- 1786
Query: 198 LKQEKQQSLQKVQFLEELWDFMGITTDEQK---AVCDDVIGLISASVDEVSIHGSLSNDI 254
+Q Q + +L + G + K A + I + V++ + +
Sbjct: 1787 ---RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 255 VKQVDVEVQR--LQVLNPSKMKEFVFKRQKELAFKRQNELEEIHRGAHMDMD------AK 306
+KQ D +++ LQV + KM E +K Q E R +L+ A + K
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 307 AARQILTDLIGNIDMSELLQGMDKQIRKAKEQA--QSRRDIIDRVAEWKSAAEEE 359
R++ N M + + ++R+ E + SRR RV E +EEE
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957
>M18A_MOUSE (Q9JMH9) Myosin XVIIIA (Myosin 18A) (Myosin containing PDZ
domain)
Length = 2035
Score = 46.2 bits (108), Expect = 2e-04
Identities = 76/382 (19%), Positives = 172/382 (44%), Gaps = 56/382 (14%)
Query: 1 MLLQIEQEYSEIYHRKVEDTIKHKDYLNKVLDDFQSEIANIASSLGE-DYVSFSRGKGTL 59
M +Q+E+EY + K K K + +S+++ ++ + + D+ S R + L
Sbjct: 1607 MEVQLEEEYED----------KQKALREK--RELESKLSTLSDQVNQRDFESEKRLRKDL 1654
Query: 60 KQQ---LANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCD 116
K+ LA+ +++ L+ + +EI ++K+Q+ + A +++ + +++
Sbjct: 1655 KRTKALLADAQIMLDHLKNNAPSK-REIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLH 1713
Query: 117 LTMEKLGKLKSHLNE----LQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSL 172
L ++ + K K+ L E LQ EKN ++++ + E D++E++ ++
Sbjct: 1714 LQIDDIAKAKTALEEQLSRLQREKN----EIQNRLEEDQE-------DMNELMKKHKAAV 1762
Query: 173 NDSSNGAQQSISDETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDD 232
+S Q ++ A++ ES +EKQ+ +K+Q L+ +F+ EQ V
Sbjct: 1763 AQASRDMAQ--MNDLQAQIEES----NKEKQELQEKLQALQSQVEFL-----EQSMVDKS 1811
Query: 233 VIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQKELAFKRQNEL 292
++ A + E+ ++ +V+RL+ L S++KE + K +E + E
Sbjct: 1812 LVSRQEAKIRELETR-------LEFEKTQVKRLENL-ASRLKETMEKLTEERDQRAAAEN 1863
Query: 293 EEIHRGAHMDMDAKAARQILTDLI-GNIDMSELLQGMDKQIRKAKEQAQS-RRDI---ID 347
E + + + ++ +++L + S ++ + + QS + D+
Sbjct: 1864 REKEQNKRLQRQLRDTKEEMSELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFK 1923
Query: 348 RVAEWKSAAEEEKWLDEYERFI 369
R+ + ++A E+E DE E I
Sbjct: 1924 RIGDLQAAIEDEMESDENEDLI 1945
>MYH6_RAT (P02563) Myosin heavy chain, cardiac muscle alpha isoform
(MyHC-alpha)
Length = 1938
Score = 45.8 bits (107), Expect = 2e-04
Identities = 76/375 (20%), Positives = 159/375 (42%), Gaps = 39/375 (10%)
Query: 18 EDTIKHKDYLNKVLDDFQSEIANIASSLGE---DYVSFSRGKGTLKQQLANIIPVVEDLR 74
E++++H + + + Q EI+++ LGE + + + L+ + + +E+
Sbjct: 1490 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAE 1549
Query: 75 FKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQN 134
+ +IL + + +QI+AE + + ++D + L + S L
Sbjct: 1550 ASLEHEEGKILRAQLEFNQIKAE-----IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1604
Query: 135 EKNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLA----- 189
E R++ ++ +L+ M I +S+ N I AQ + D L
Sbjct: 1605 ETRSRNEALRVKKKMEGDLNE-MEIQLSQ-ANRIASEAQKHLKNAQAHLKDTQLQLDDAV 1662
Query: 190 ----RLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVS 245
L E++ ++ E++ +L + + LEEL + T +K ++I + + V
Sbjct: 1663 RANDDLKENIAIV--ERRNTLLQAE-LEELRAVVEQTERSRKLAEQELI----ETSERVQ 1715
Query: 246 IHGSLSNDIV---KQVDVEVQRLQ------VLNPSKMKEFVFKRQKELAFKRQNELEEIH 296
+ S + ++ K++D ++ +LQ V +E K + A + +E
Sbjct: 1716 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 297 RGAHMDMDAKAARQILTDLIGNIDMSE--LLQGMDKQIRKAKEQAQSRRDIIDRVAEWKS 354
AH++ K Q + DL +D +E L+G KQ++K + + + + ++ AE K
Sbjct: 1776 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE--AEQKR 1833
Query: 355 AAEEEKWLDEYERFI 369
AE K + + ER I
Sbjct: 1834 NAESVKGMRKSERRI 1848
Score = 34.7 bits (78), Expect = 0.48
Identities = 54/294 (18%), Positives = 113/294 (38%), Gaps = 56/294 (19%)
Query: 16 KVEDTIKHKDYLNKVLDDFQSEIANIASSLGEDYVSFSRGKGTLKQQLANIIPVVEDLRF 75
+V+D ++ + K L++ + + L + +++ +I L
Sbjct: 859 RVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 918
Query: 76 KKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEKLGKLKSHLNELQNE 135
K KE + + + + +++ A+K +D+D +LT+ K+ K E
Sbjct: 919 KVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEK----------E 968
Query: 136 KNIRHQKVKSHISTISELSAVMSIDISEILNGIHPSLNDSSNGAQQSISDETLARLNESV 195
K+ KVK +++E + G+ DE +A+L +
Sbjct: 969 KHATENKVK---------------NLTEEMAGL----------------DEIIAKLTKEK 997
Query: 196 LLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVD--------EVSIH 247
L++ QQ+L +Q E+ + + + + + DD+ G + + +
Sbjct: 998 KALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1057
Query: 248 GSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQ-------KELAFKRQNELEE 294
G L +D+E +LQ+ K KEF +Q + LA + Q +L+E
Sbjct: 1058 GDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKE 1111
>MYH6_HUMAN (P13533) Myosin heavy chain, cardiac muscle alpha isoform
(MyHC-alpha)
Length = 1939
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/260 (19%), Positives = 116/260 (44%), Gaps = 23/260 (8%)
Query: 58 TLKQQLANIIPVVEDLRFKKKE---RVKEILEIKSQIS-QIRAEKAGCGQSKGVTDQDVD 113
T+K++ I +E ++KE ++ +L+ K+ + Q++AE+ ++ DQ +
Sbjct: 853 TMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIK 912
Query: 114 ---QCDLTMEKLGKLKSHLNELQNEKNIRHQKVKSHISTISELSAVMSIDISEILNGIHP 170
Q + ++++ + E+ E + +K++ S + + + + ++++ H
Sbjct: 913 NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 972
Query: 171 SLNDSSNGAQQSIS-DETLARLNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAV 229
+ N N ++ DE +A+L + L++ QQ+L +Q E+ + + + + +
Sbjct: 973 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQ 1032
Query: 230 CDDVIGLISASVD--------EVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKEFVFKRQ 281
DD+ G + + + G L +D+E +LQ+ K KEF +Q
Sbjct: 1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQ 1092
Query: 282 -------KELAFKRQNELEE 294
+ LA + Q +L+E
Sbjct: 1093 NSKIEDEQALALQLQKKLKE 1112
Score = 41.2 bits (95), Expect = 0.005
Identities = 72/375 (19%), Positives = 163/375 (43%), Gaps = 39/375 (10%)
Query: 18 EDTIKHKDYLNKVLDDFQSEIANIASSLGE---DYVSFSRGKGTLKQQLANIIPVVEDLR 74
E++++H + + + Q EI+++ LGE + + + L+ + + +E+
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Query: 75 FKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVDQCDLTMEK-LGKLKSHLNELQ 133
+ +IL + + +QI+AE + D++++Q ++ + L++ L+
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAE---IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 134 NEKNIRHQKVKSHISTISELSAV------MSIDISEILNGIHPSLNDSSNGAQQSISDET 187
+N + K ++E+ M+ + + + + L D+ Q + D
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT----QIQLDDAV 1663
Query: 188 LAR--LNESVLLLKQEKQQSLQKVQFLEELWDFMGITTDEQKAVCDDVIGLISASVDEVS 245
A L E++ ++ E++ +L + + LEEL + T +K ++I + + V
Sbjct: 1664 RANDDLKENIAIV--ERRNNLLQAE-LEELRAVVEQTERSRKLAEQELI----ETSERVQ 1716
Query: 246 IHGSLSNDIV---KQVDVEVQRLQ------VLNPSKMKEFVFKRQKELAFKRQNELEEIH 296
+ S + ++ K+++ ++ +LQ V +E K + A + +E
Sbjct: 1717 LLHSQNTSLINQKKKMEADLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1776
Query: 297 RGAHMDMDAKAARQILTDLIGNIDMSE--LLQGMDKQIRKAKEQAQSRRDIIDRVAEWKS 354
AH++ K Q + DL +D +E L+G KQ++K + + + ++ AE K
Sbjct: 1777 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELE--AEQKR 1834
Query: 355 AAEEEKWLDEYERFI 369
AE K + + ER I
Sbjct: 1835 NAESVKGMRKSERRI 1849
>PLE1_HUMAN (Q15149) Plectin 1 (PLTN) (PCN) (Hemidesmosomal protein 1)
(HD1)
Length = 4684
Score = 45.1 bits (105), Expect = 4e-04
Identities = 74/401 (18%), Positives = 173/401 (42%), Gaps = 66/401 (16%)
Query: 54 RGKGTLKQQLANIIPVVEDLRFKKKERVKEILEIKSQISQIRAEKAGCGQSKGVTDQDVD 113
R K ++Q+L + L+ ++ + K +L+ ++ +++AE + + ++++
Sbjct: 2316 RQKAQVEQELTTL-----RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELF 2368
Query: 114 QCDLTMEKLGKLKSHLNE------LQNEKNIRH--QKVKSHISTISELSAVMSIDISEIL 165
+ ME+L KLK+ + L+++ N + Q+ + ++E +A +S+ E
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 166 NGIHPSLNDSSNGAQQSISDETL----------ARLNESVLLLKQEKQQSLQKVQFLEEL 215
L + Q++++++ L RL LL+Q+K+ + ++ + L+E
Sbjct: 2429 R--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2486
Query: 216 WDFMGITTDEQKAVCDDVIGLISASVDEVSIHGSLSNDIVKQVDVEVQRLQVLNPSKMKE 275
+ M + + ++ G + ++ + + E +L+V S+ +
Sbjct: 2487 KEQMA------QQLAEETQGF------QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2533
Query: 276 FVFKRQKELAFKRQNELEEIHRGAHMDMDAKAARQILTDLIGNIDM--------SELLQG 327
R +E A + + + EEI H + A Q L+ +++ +E L+
Sbjct: 2534 ---ARAEEDAQRFRKQAEEIGEKLHR---TELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 328 MDKQIRKAKEQAQSRRDIIDRVAEWKSAAEEEKWLDEYERFI*SVRRKRGFLSPRFHLW* 387
++ + KE+ Q ++ +E ++E+ L E + ++ FLS + L
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL------QQSFLSEKDSL-- 2639
Query: 388 RI*LQK*KHGRQTKKKVSYMKSLHEYNVQRQLREEEKRKSR 428
LQ+ + Q K K+ + E +QLREE++R+ +
Sbjct: 2640 ---LQRERFIEQEKAKLEQLFQ-DEVAKAQQLREEQQRQQQ 2676
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.135 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,736,516
Number of Sequences: 164201
Number of extensions: 1702867
Number of successful extensions: 8628
Number of sequences better than 10.0: 288
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 271
Number of HSP's that attempted gapping in prelim test: 8159
Number of HSP's gapped (non-prelim): 624
length of query: 428
length of database: 59,974,054
effective HSP length: 113
effective length of query: 315
effective length of database: 41,419,341
effective search space: 13047092415
effective search space used: 13047092415
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Medicago: description of AC137821.2