BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC136954.8 + phase: 0
(482 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
KDGE_MOUSE (Q9R1C6) Diacylglycerol kinase, epsilon (EC 2.7.1.107... 147 5e-35
KDGE_HUMAN (P52429) Diacylglycerol kinase, epsilon (EC 2.7.1.107... 147 8e-35
KDG3_CAEEL (Q03603) Probable diacylglycerol kinase 3 (EC 2.7.1.1... 144 5e-34
KDG1_ARATH (Q39017) Diacylglycerol kinase 1 (EC 2.7.1.107) (Digl... 138 4e-32
KDGT_HUMAN (P52824) Diacylglycerol kinase, theta (EC 2.7.1.107) ... 137 5e-32
KDGI_HUMAN (O75912) Diacylglycerol kinase, iota (EC 2.7.1.107) (... 137 6e-32
KDGZ_RAT (O08560) Diacylglycerol kinase, zeta (EC 2.7.1.107) (Di... 134 7e-31
KDGZ_MOUSE (Q80UP3) Diacylglycerol kinase, zeta (EC 2.7.1.107) (... 134 7e-31
KDGG_HUMAN (P49619) Diacylglycerol kinase, gamma (EC 2.7.1.107) ... 134 7e-31
KDGM_CAEEL (Q10024) Putative diacylglycerol kinase K06A1.6 (EC 2... 133 9e-31
KDGZ_HUMAN (Q13574) Diacylglycerol kinase, zeta (EC 2.7.1.107) (... 133 1e-30
KDGG_RAT (P49620) Diacylglycerol kinase, gamma (EC 2.7.1.107) (D... 132 2e-30
KDGB_HUMAN (Q9Y6T7) Diacylglycerol kinase, beta (EC 2.7.1.107) (... 132 2e-30
KDGG_MOUSE (Q91WG7) Diacylglycerol kinase, gamma (EC 2.7.1.107) ... 131 3e-30
KDGE_DROME (Q09103) Eye-specific diacylglycerol kinase (EC 2.7.1... 131 3e-30
KDGA_RAT (P51556) Diacylglycerol kinase, alpha (EC 2.7.1.107) (D... 129 1e-29
KDGA_MOUSE (O88673) Diacylglycerol kinase, alpha (EC 2.7.1.107) ... 129 2e-29
KDGL_DROME (Q01583) Diacylglycerol kinase (EC 2.7.1.107) (Diglyc... 97 1e-19
KDGD_MESAU (Q64398) Diacylglycerol kinase, delta (EC 2.7.1.107) ... 93 1e-18
KDGD_HUMAN (Q16760) Diacylglycerol kinase, delta (EC 2.7.1.107) ... 89 3e-17
>KDGE_MOUSE (Q9R1C6) Diacylglycerol kinase, epsilon (EC 2.7.1.107)
(Diglyceride kinase) (DGK-epsilon) (DAG kinase epsilon)
Length = 564
Score = 147 bits (372), Expect = 5e-35
Identities = 111/375 (29%), Positives = 176/375 (46%), Gaps = 66/375 (17%)
Query: 84 SPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDS 143
+P+++ N+RSG G L + L++ QVFD+ P + L++
Sbjct: 215 TPLIILANSRSGTNMGEGLLGEFKILLNPVQVFDVTKTPP-------IKALQL------- 260
Query: 144 CAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREP-VPPVGIVPLGTGNDLSRSFNWG 202
C +RV+V GGDGTVGWVL + E++ G+E +P V ++PLGTGNDLS + WG
Sbjct: 261 CTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEVAVLPLGTGNDLSNTLGWG 320
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
+ A + + + L+ +LD W++ + T K Y L++ +EFT++
Sbjct: 321 TGY--AGEIPVAQVLRNVMEADGIKLDRWKVQV------TNKGYYNLRKPKEFTMN---- 368
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
NYFS+G DA +A FH R++ P L S I NK +Y Y T+
Sbjct: 369 -----------------NYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYG-TK 410
Query: 323 GWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNPWG 382
C + L + + + + E+V +P ++ I+ LN+ +G G W
Sbjct: 411 DCLVQEC------KDLNKKIELEL------DGERVELP-NLEGIIVLNIGYWGGGCRLW- 456
Query: 383 KPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRGGG 442
E + + + A DG LEI G+ +H + + V L I QA +RL L+
Sbjct: 457 ----EGMGDETYPLARHDDGLLEIVGVYGSFHCAQIQVKLANPFRIGQAHTVRLTLK--- 509
Query: 443 WKNAYLQMDGEPWKQ 457
+Q+DGEPW Q
Sbjct: 510 CSMMPMQVDGEPWAQ 524
>KDGE_HUMAN (P52429) Diacylglycerol kinase, epsilon (EC 2.7.1.107)
(Diglyceride kinase) (DGK-epsilon) (DAG kinase epsilon)
Length = 567
Score = 147 bits (370), Expect = 8e-35
Identities = 111/375 (29%), Positives = 176/375 (46%), Gaps = 66/375 (17%)
Query: 84 SPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDS 143
+P+++ N+RSG G L + L++ QVFD+ P + L++
Sbjct: 218 TPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPP-------IKALQL------- 263
Query: 144 CAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREP-VPPVGIVPLGTGNDLSRSFNWG 202
C RV+V GGDGTVGWVL + +++ G+E +P V ++PLGTGNDLS + WG
Sbjct: 264 CTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWG 323
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
+ A + + + L+ +LD W++ + T K Y L++ +EFT++
Sbjct: 324 TGY--AGEIPVAQVLRNVMEADGIKLDRWKVQV------TNKGYYNLRKPKEFTMN---- 371
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
NYFS+G DA +A FH R++ P L S I NK +Y Y T+
Sbjct: 372 -----------------NYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYG-TK 413
Query: 323 GWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNPWG 382
C + L + + + + E+VA+P S+ I+ LN+ +G G W
Sbjct: 414 DCLVQEC------KDLNKKVELEL------DGERVALP-SLEGIIVLNIGYWGGGCRLW- 459
Query: 383 KPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRGGG 442
E + + + A DG LE+ G+ +H + + V L I QA +RL L+
Sbjct: 460 ----EGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILK--- 512
Query: 443 WKNAYLQMDGEPWKQ 457
+Q+DGEPW Q
Sbjct: 513 CSMMPMQVDGEPWAQ 527
>KDG3_CAEEL (Q03603) Probable diacylglycerol kinase 3 (EC 2.7.1.107)
(Diglyceride kinase 3) (DGK 3) (DAG kinase 3)
Length = 812
Score = 144 bits (363), Expect = 5e-34
Identities = 103/388 (26%), Positives = 177/388 (45%), Gaps = 71/388 (18%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++V +N +SGG+ G + ++ + L++ QV+DL+ P GL L
Sbjct: 427 PLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSKTGPEP----GLQLFSTL------- 475
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELR-QLGREPVPPVGIVPLGTGNDLSRSFNWGG 203
+ ++V GGDGT+GWVL + ++ GR PPV ++PLGTGNDL+R WGG
Sbjct: 476 -----KNCNILVCGGDGTIGWVLESMDKMTFPHGR---PPVAVLPLGTGNDLARCLRWGG 527
Query: 204 SFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEI 263
+ + + L++ S+ +D W++ I + E+ + ++A E
Sbjct: 528 GYE---NENLHKILEQIEKSSLIDMDRWQIKIEITENKSA------RRASE--------- 569
Query: 264 EGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQG 323
+G+ P + NYFSIG+DA +A+ FH +R++ P + + NK+
Sbjct: 570 KGDTPP-----YSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKL---------- 614
Query: 324 WFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNPWGK 383
W+F TS+ +N L I + E + S+ I LN+ S G N WG+
Sbjct: 615 WYFELGTSETLSSSCKN-LHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGR 673
Query: 384 PKPEYLEKKGFVE-------------ADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQ 430
+ G D+ DG +E+ GL+ + + A+ ++Q
Sbjct: 674 SRKSKGRMPGLFPMKNAEKMQLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGARRLSQ 733
Query: 431 AAAIRLELRGGGWKNAYLQMDGEPWKQP 458
+ + ++ K+ +Q+DGEPW QP
Sbjct: 734 CSTVVIQTH----KSFPMQIDGEPWMQP 757
>KDG1_ARATH (Q39017) Diacylglycerol kinase 1 (EC 2.7.1.107)
(Diglyceride kinase 1) (DGK 1) (DAG kinase 1)
Length = 728
Score = 138 bits (347), Expect = 4e-32
Identities = 102/381 (26%), Positives = 161/381 (41%), Gaps = 68/381 (17%)
Query: 78 DSAAPTSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEML 137
D + P++VFIN +SG + G +L++RL ++ QVF+L+ V+ E L+ +
Sbjct: 354 DLPSDARPLLVFINKKSGAQRGDSLRQRLHLHLNPVQVFELSSVQGPEVGLFLFRKV--- 410
Query: 138 AGLGDSCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSR 197
RV+V GGDGT GWVL + + + P V I+P GTGNDLSR
Sbjct: 411 ------------PHFRVLVCGGDGTAGWVLDAIEKQNFIS---PPAVAILPAGTGNDLSR 455
Query: 198 SFNWGGSF-PFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFT 256
NWGG + + LQ +V LD W++SI + ++PP +
Sbjct: 456 VLNWGGGLGSVERQGGLSTVLQNIEHAAVTVLDRWKVSILNQQGKQLQPPKYMN------ 509
Query: 257 LDQGIEIEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYS 316
NY +G DA+VA H LR+E P NK++Y+
Sbjct: 510 -----------------------NYIGVGCDAKVALEIHNLREENPERFYSQFMNKVLYA 546
Query: 317 GYSCTQGWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGS 376
D +R+ + V + +P+ I+ N+ SY
Sbjct: 547 REGARS-------IMDRTFEDFPWQVRVEVDGV------DIEVPEDAEGILVANIGSYMG 593
Query: 377 GRNPWGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRL 436
G + W Y + F + D +E+ + WH + V L A+ +AQ +A+++
Sbjct: 594 GVDLWQNEDETY---ENFDPQSMHDKIVEVVSISGTWHLGKLQVGLSRARRLAQGSAVKI 650
Query: 437 ELRGGGWKNAYLQMDGEPWKQ 457
+L +Q+DGEPW Q
Sbjct: 651 QL----CAPLPVQIDGEPWNQ 667
>KDGT_HUMAN (P52824) Diacylglycerol kinase, theta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-theta) (DAG kinase theta)
Length = 942
Score = 137 bits (346), Expect = 5e-32
Identities = 116/377 (30%), Positives = 168/377 (43%), Gaps = 72/377 (19%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VF+N +SGG G L ++L++ QVFDL + P L GL + C
Sbjct: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGP----LPGLHLFSQVP-----C 638
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG-- 202
RV+V GGDGTVGWVLG L E R P P V I+PLGTGNDL R WG
Sbjct: 639 -------FRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAG 691
Query: 203 --GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQG 260
G PF+ L +D W + + E+ + AE T D
Sbjct: 692 YSGEDPFS-------VLLSVDEADAVLMDRWTILLDAHEAGS---------AENDTADAE 735
Query: 261 IEIEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSC 320
P K+ NY IG+DA+++ FH+ R+E+P + + NK +Y
Sbjct: 736 -------PPKIVQMS----NYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRV-- 782
Query: 321 TQGWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNP 380
GL+ + + +H + E ++V +P S+ ++ +N+ S+GSG +
Sbjct: 783 -------------GLQKISHSRSLHKQIRLQVERQEVELP-SIEGLIFINIPSWGSGADL 828
Query: 381 WGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRG 440
WG EK + DG LE+ G+ H V L + IAQ + R+ L
Sbjct: 829 WGSDSDTRFEK-----PRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTL-- 881
Query: 441 GGWKNAYLQMDGEPWKQ 457
K +Q+DGEPW Q
Sbjct: 882 --LKATPVQVDGEPWVQ 896
>KDGI_HUMAN (O75912) Diacylglycerol kinase, iota (EC 2.7.1.107)
(Diglyceride kinase) (DGK-iota) (DAG kinase iota)
Length = 1065
Score = 137 bits (345), Expect = 6e-32
Identities = 111/371 (29%), Positives = 167/371 (44%), Gaps = 64/371 (17%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VF+N +SGG G + + ++ QVFDL+ P + LE+ + +
Sbjct: 376 PLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKD-------ALELYRKVPN-- 426
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGS 204
LR++ GGDGTVGW+L L EL+ P PPVG++PLGTGNDL+R+ NWGG
Sbjct: 427 -------LRILACGGDGTVGWILSILDELQL---SPQPPVGVLPLGTGNDLARTLNWGGG 476
Query: 205 FPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEIE 264
+ + + L + G+V +LD W L + E PP EE L+ G+
Sbjct: 477 YT---DEPVSKILCQVEDGTVVQLDRWNLHV---ERNPDLPP------EE--LEDGV--- 519
Query: 265 GELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGW 324
K V+ NYFS+G DA V FH R+ P + NK+ Y+G + +
Sbjct: 520 ------CKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSD-- 571
Query: 325 FFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPK-SVRAIVALNLHSYGSGRNPWGK 383
F + D L H+K V I + + IV LN+ Y +G PWG
Sbjct: 572 FLQRSSRD---------LSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGN 622
Query: 384 PKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRGGGW 443
P + F DG +E+ G A+ + + + Q + L +
Sbjct: 623 PGDHH----DFEPQRHDDGYIEVIGFTMASLAALQVGG--HGERLHQCREVMLLT----Y 672
Query: 444 KNAYLQMDGEP 454
K+ +Q+DGEP
Sbjct: 673 KSIPMQVDGEP 683
>KDGZ_RAT (O08560) Diacylglycerol kinase, zeta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-zeta) (DAG kinase zeta)
(DGK-IV) (104 kDa diacylglycerol kinase)
Length = 929
Score = 134 bits (336), Expect = 7e-31
Identities = 116/387 (29%), Positives = 163/387 (41%), Gaps = 81/387 (20%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VF+N +SGG G + + ++ QVFDL+ P E LEM +
Sbjct: 296 PLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPRE-------ALEMYRKV---- 344
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGS 204
LR++ GGDGTVGW+L L +LR +P PPV I+PLGTGNDL+R+ NWGG
Sbjct: 345 -----HNLRILACGGDGTVGWILSTLDQLRL---KPPPPVAILPLGTGNDLARTLNWGGG 396
Query: 205 FPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEIE 264
+ + + L G+V +LD W L P ++ ++ D+
Sbjct: 397 YT---DEPVSKILSHVEEGNVVQLDRWDL------RAEPNPEAGPEERDDGATDR----- 442
Query: 265 GELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGW 324
LP V+ NYFS+G DA V FH R+ P + NK+ Y+G + +
Sbjct: 443 --LP------LDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSD-- 492
Query: 325 FFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPK----SVRAIVALNLHSYGSGRNP 380
L G L HI+ V PK + IV LN+ Y +G P
Sbjct: 493 ---------FLMGSSKDLAKHIRVVCDG---MDLTPKIQDLKPQCIVFLNIPRYCAGTMP 540
Query: 381 WGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLIT------AKHIAQAAAI 434
WG P E F DG LE+ G F M L + + Q +
Sbjct: 541 WGHPG----EHHDFEPQRHDDGYLEVIG--------FTMTSLAALQVGGHGERLTQCREV 588
Query: 435 RLELRGGGWKNAYLQMDGEPWKQPLSK 461
L K +Q+DGEP K S+
Sbjct: 589 LLTTA----KAIPVQVDGEPCKLAASR 611
>KDGZ_MOUSE (Q80UP3) Diacylglycerol kinase, zeta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-zeta) (DAG kinase zeta)
Length = 929
Score = 134 bits (336), Expect = 7e-31
Identities = 116/387 (29%), Positives = 163/387 (41%), Gaps = 81/387 (20%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VF+N +SGG G + + ++ QVFDL+ P E LEM +
Sbjct: 296 PLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPRE-------ALEMYRKV---- 344
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGS 204
LR++ GGDGTVGW+L L +LR +P PPV I+PLGTGNDL+R+ NWGG
Sbjct: 345 -----HNLRILACGGDGTVGWILSTLDQLRL---KPPPPVAILPLGTGNDLARTLNWGGG 396
Query: 205 FPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEIE 264
+ + + L G+V +LD W L P ++ ++ D+
Sbjct: 397 YT---DEPVSKILSHVEEGNVVQLDRWDL------RAEPNPEAGPEERDDGATDR----- 442
Query: 265 GELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGW 324
LP V+ NYFS+G DA V FH R+ P + NK+ Y+G + +
Sbjct: 443 --LP------LDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSD-- 492
Query: 325 FFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPK----SVRAIVALNLHSYGSGRNP 380
L G L HI+ V PK + IV LN+ Y +G P
Sbjct: 493 ---------FLMGSSKDLAKHIRVVCDG---MDLTPKIQDLKPQCIVFLNIPRYCAGTMP 540
Query: 381 WGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLIT------AKHIAQAAAI 434
WG P E F DG LE+ G F M L + + Q +
Sbjct: 541 WGHPG----EHHDFEPQRHDDGYLEVIG--------FTMTSLAALQVGGHGERLTQCREV 588
Query: 435 RLELRGGGWKNAYLQMDGEPWKQPLSK 461
L K +Q+DGEP K S+
Sbjct: 589 LLTTA----KAIPVQVDGEPCKLSASR 611
>KDGG_HUMAN (P49619) Diacylglycerol kinase, gamma (EC 2.7.1.107)
(Diglyceride kinase) (DGK-gamma) (DAG kinase gamma)
Length = 791
Score = 134 bits (336), Expect = 7e-31
Identities = 123/452 (27%), Positives = 197/452 (43%), Gaps = 89/452 (19%)
Query: 26 RGCGLSGMRIDKEDLKKQLTLPQYLRFAMRDSIRLQDPSAGETLYRNRAEGEDSAAPTS- 84
R C LS + D +L+ + LP + RD R + S G + + PT
Sbjct: 375 RKCELSTL-CDGGELRDHILLPTSICPITRD--RPGEKSDGCVSAKGELVMQYKIIPTPG 431
Query: 85 --PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
P++V +N +SGGR G + + L++ +QVF+L + P G
Sbjct: 432 THPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTP---------------GL 476
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
+ ++T + RV+ GGDGTVGW+L C+ + PPV ++PLGTGNDL+R WG
Sbjct: 477 NFFRDTPD-FRVLACGGDGTVGWILDCIDKANFAKH---PPVAVLPLGTGNDLARCLRWG 532
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
G + ++ + L+ + LD W L + E +E
Sbjct: 533 GGYE---GGSLTKILKDIEQSPLVMLDRWHLEVIPREE--------------------VE 569
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
++P + + NYFSIG+DA +A+ FH +R++ P + + NK+
Sbjct: 570 NGDQVPYSIMN------NYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKL--------- 614
Query: 323 GWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKS---VRAIVALNLHSYGSGRN 379
W+F TS+ + L HI+ E + V + S + I LN+ S G N
Sbjct: 615 -WYFEFGTSETFAATCKK-LHDHIE----LECDGVGVDLSNIFLEGIAILNIPSMYGGTN 668
Query: 380 PWGKPKPEYL----EKKG--------FVEADVADGRLEIFGLKQGWHASFVMVDLITA-K 426
WG+ K +KG F D++D LE+ GL+ + L +A +
Sbjct: 669 LWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGR 728
Query: 427 HIAQAAAIRLELRGGGWKNAYLQMDGEPWKQP 458
+AQ A++ + K +Q+DGEPW QP
Sbjct: 729 RLAQCASVTIRTN----KLLPMQVDGEPWMQP 756
>KDGM_CAEEL (Q10024) Putative diacylglycerol kinase K06A1.6 (EC
2.7.1.107) (Diglyceride kinase) (DGK) (DAG kinase)
Length = 937
Score = 133 bits (335), Expect = 9e-31
Identities = 111/376 (29%), Positives = 163/376 (42%), Gaps = 62/376 (16%)
Query: 79 SAAPTSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLA 138
S+ P+ P++VF+N +SGG G L L++ QVFD+ +K +F L EM
Sbjct: 412 SSGPSQPLLVFVNPKSGGNKGSKALHTLCWLLNPRQVFDITSLKGPKFGL------EMF- 464
Query: 139 GLGDSCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRS 198
++ +LR++V GGDGTVGWVL L L PP+ I+PLGTGNDL+R
Sbjct: 465 -------RKVVTQLRILVCGGDGTVGWVLSTLDNLNW---PAYPPMAIMPLGTGNDLARC 514
Query: 199 FNWGGSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLD 258
WGG F S + + + ++ V LD WR+ V+P EE D
Sbjct: 515 MGWGGVFSDEPISQLMQAILHETI--VTHLDRWRID--------VEPNTSCNLEEE---D 561
Query: 259 QGIEIEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGY 318
G ++ LP V + NYFSIG DA VA FH R P + + + N+I Y G
Sbjct: 562 DG--MQSALPLTVMT------NYFSIGADAHVALQFHHSRSANPQMLNSRLKNRIAYGGL 613
Query: 319 SCTQGWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGR 378
T D R +++ + + I+ N+ Y G
Sbjct: 614 G----------TIDLFKRSWKDLCEYITLECDGVDVTPRIKELKLHCILFHNITYYAGGT 663
Query: 379 NPWGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLEL 438
PWG+ + DG++E+ G A+ M + IAQ + +R+
Sbjct: 664 IPWGESSDN--------KPSCCDGKVEVLGFTTATLAALQMGG--KGERIAQCSRVRVIT 713
Query: 439 RGGGWKNAYLQMDGEP 454
K +Q+DGEP
Sbjct: 714 N----KAIPMQVDGEP 725
>KDGZ_HUMAN (Q13574) Diacylglycerol kinase, zeta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-zeta) (DAG kinase zeta)
Length = 1117
Score = 133 bits (334), Expect = 1e-30
Identities = 116/387 (29%), Positives = 162/387 (40%), Gaps = 81/387 (20%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VF+N +SGG G + + ++ QVFDL+ P E LEM +
Sbjct: 484 PLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKE-------ALEMYRKV---- 532
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGS 204
LR++ GGDGTVGW+L L +LR +P PPV I+PLGTGNDL+R+ NWGG
Sbjct: 533 -----HNLRILACGGDGTVGWILSTLDQLRL---KPPPPVAILPLGTGNDLARTLNWGGG 584
Query: 205 FPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEIE 264
+ + + L G+V +LD W L P + +E D+
Sbjct: 585 YT---DEPVSKILSHVEEGNVVQLDRWDL------HAEPNPEAGPEDRDEGATDR----- 630
Query: 265 GELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGW 324
LP V+ NYFS+G DA V FH R+ P + NK+ Y+G + +
Sbjct: 631 --LP------LDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSD-- 680
Query: 325 FFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPK----SVRAIVALNLHSYGSGRNP 380
L G L HI+ V PK + +V LN+ Y +G P
Sbjct: 681 ---------FLMGSSKDLAKHIRVVCDG---MDLTPKIQDLKPQCVVFLNIPRYCAGTMP 728
Query: 381 WGKPKPEYLEKKGFVEADVADGRLEIFGLKQGWHASFVMVDLIT------AKHIAQAAAI 434
WG P E F DG LE+ G F M L + + Q +
Sbjct: 729 WGHPG----EHHDFEPQRHDDGYLEVIG--------FTMTSLAALQVGGHGERLTQCREV 776
Query: 435 RLELRGGGWKNAYLQMDGEPWKQPLSK 461
L K +Q+DGEP K S+
Sbjct: 777 VLTTS----KAIPVQVDGEPCKLAASR 799
>KDGG_RAT (P49620) Diacylglycerol kinase, gamma (EC 2.7.1.107)
(Diglyceride kinase) (DGK-gamma) (DAG kinase gamma) (88
kDa diacylglycerol kinase)
Length = 788
Score = 132 bits (332), Expect = 2e-30
Identities = 123/456 (26%), Positives = 201/456 (43%), Gaps = 97/456 (21%)
Query: 26 RGCGLSGMRIDKEDLKKQLTLPQYLRFAMRDSIRLQDPSAGETLYRNRAEGE-------D 78
R C LS D +LK + LP + RD AG++ A+GE
Sbjct: 372 RKCELS-TACDGGELKDHILLPTSIYPVTRDR------QAGKSDSGAAAKGELVMQYKII 424
Query: 79 SAAPTSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLA 138
+ T P++V +N +SGGR G + ++ L++ +QVF+L P
Sbjct: 425 PSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTP------------- 471
Query: 139 GLGDSCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRS 198
G + ++T + RV+ GGDGTVGW+L C+ + PPV ++PLGTGNDL+R
Sbjct: 472 --GLNFFQDTPD-FRVLACGGDGTVGWILDCIDKANFTKH---PPVAVLPLGTGNDLARC 525
Query: 199 FNWGGSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLD 258
WGG + ++ + L++ + LD W L + MP
Sbjct: 526 LRWGGGYE---GGSLTKILKEIEQSPLVMLDRWYLEV-MPR------------------- 562
Query: 259 QGIEIEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGY 318
+ +E ++P + + NYFSIG+DA +A+ FH +R++ P + + NK+
Sbjct: 563 EEVENGDQVPYNIMN------NYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKL----- 611
Query: 319 SCTQGWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKS---VRAIVALNLHSYG 375
W+F TS+ + L HI+ E + V + S + I LN+ S
Sbjct: 612 -----WYFEFGTSETFAATCKK-LHDHIE----LECDGVEVDLSNIFLEGIAILNIPSMY 661
Query: 376 SGRNPWGKPKPEYL----EKKGFVE--------ADVADGRLEIFGLKQGWHASFVMVDLI 423
G N WG+ K +K + D++D LE+ GL+ + L
Sbjct: 662 GGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLK 721
Query: 424 TA-KHIAQAAAIRLELRGGGWKNAYLQMDGEPWKQP 458
+A + +AQ +++ + + K +Q+DGEPW QP
Sbjct: 722 SAGRRLAQCSSVTIRTK----KLLPMQVDGEPWMQP 753
>KDGB_HUMAN (Q9Y6T7) Diacylglycerol kinase, beta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-beta) (DAG kinase beta) (90
kDa diacylglycerol kinase)
Length = 804
Score = 132 bits (332), Expect = 2e-30
Identities = 111/395 (28%), Positives = 171/395 (43%), Gaps = 85/395 (21%)
Query: 83 TSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
T P++VF+N +SGG+ G + + Q L++ QV+ L+ P + L + D
Sbjct: 436 THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGP-------MPGLNFFRDVPD 488
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
RV+ GGDGTVGWVL C+ E +G+ P PV I+PLGTGNDL+R WG
Sbjct: 489 ---------FRVLACGGDGTVGWVLDCI-EKANVGKHP--PVAILPLGTGNDLARCLRWG 536
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
G + + + L+ + LD W+ + +P
Sbjct: 537 GGYE---GENLMKILKDIENSTEIMLDRWKFEV-IPND---------------------- 570
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
+ E D V + NYFSIG+DA +A+ FH +R++ P + + NK Y + T
Sbjct: 571 -KDEKGDPVP--YSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFG-TS 626
Query: 323 GWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQV-AIPKSVRAIVALNLHSYGSGRNPW 381
F C ++H + Q+ I S+ I LN+ S G N W
Sbjct: 627 ETFSATCK------------KLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLW 674
Query: 382 GKPKP----EYLEKKG--------------FVEADVADGRLEIFGLKQGWHASFVMVDLI 423
G+ K +EKKG F D++D LE+ GL+ + L
Sbjct: 675 GESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLK 734
Query: 424 TA-KHIAQAAAIRLELRGGGWKNAYLQMDGEPWKQ 457
+A + +AQ + + + K+ +Q+DGEPW Q
Sbjct: 735 SAGRRLAQCSCVVIRTS----KSLPMQIDGEPWMQ 765
>KDGG_MOUSE (Q91WG7) Diacylglycerol kinase, gamma (EC 2.7.1.107)
(Diglyceride kinase) (DGK-gamma) (DAG kinase gamma) (88
kDa diacylglycerol kinase)
Length = 788
Score = 131 bits (330), Expect = 3e-30
Identities = 122/452 (26%), Positives = 196/452 (42%), Gaps = 89/452 (19%)
Query: 26 RGCGLSGMRIDKEDLKKQLTLPQYLRFAMRDSIRLQDPSAGETLYRNRAEGEDSAAP--- 82
R C LS + D +LK + LP + D R S G + + P
Sbjct: 372 RKCELSTV-CDGGELKDHILLPTSICPVSGD--RQGGKSDGSVAAKGELVTQYKIIPSPG 428
Query: 83 TSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
T P++V +N +SGGR G + + L++ EQVF+L + P G
Sbjct: 429 THPLLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDNGGPTP---------------GL 473
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
+ +T + RV+ GGDGTVGW+L C+ + PPV ++PLGTGNDL+R WG
Sbjct: 474 NFFHDTPD-FRVLACGGDGTVGWILDCIDKANFTKH---PPVAVLPLGTGNDLARCLRWG 529
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
G + ++ + L++ + LD W L + MP + +E
Sbjct: 530 GGYE---GGSLTKILKEIEQSPLVMLDRWYLEV-MPR-------------------EEVE 566
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
++P + + NYFSIG+DA +A+ FH +R++ P + + NK+
Sbjct: 567 NGDQVPYNIMN------NYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKL--------- 611
Query: 323 GWFFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKS---VRAIVALNLHSYGSGRN 379
W+F TS+ + L HI+ E + V + S + I LN+ S G N
Sbjct: 612 -WYFEFGTSETFAATCKK-LHDHIE----LECDGVEVDLSNIFLEGIAILNIPSMYGGTN 665
Query: 380 PWGKPKPEYL----EKKGFVE--------ADVADGRLEIFGLKQGWHASFVMVDLITA-K 426
WG+ K +K + D++D LE+ GL+ + L +A +
Sbjct: 666 LWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGR 725
Query: 427 HIAQAAAIRLELRGGGWKNAYLQMDGEPWKQP 458
+AQ +++ + K +Q+DGEPW QP
Sbjct: 726 RLAQCSSVTIRTN----KLLPMQVDGEPWMQP 753
>KDGE_DROME (Q09103) Eye-specific diacylglycerol kinase (EC 2.7.1.107)
(Retinal degeneration A protein) (Diglyceride kinase 2)
(DGK 2) (DAG kinase 2)
Length = 1454
Score = 131 bits (330), Expect = 3e-30
Identities = 95/325 (29%), Positives = 141/325 (43%), Gaps = 57/325 (17%)
Query: 85 PMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSC 144
P++VFIN +SGG G L + Q L++ QVFDL P L+M
Sbjct: 809 PVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPK-------MGLDMF------- 854
Query: 145 AKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGS 204
LRV+ GGDGTVGWVL L ++ Q +P P VG++PLGTGNDL+R+ WGG
Sbjct: 855 --RKAPNLRVLACGGDGTVGWVLSVLDQI-QPPLQPAPAVGVLPLGTGNDLARALGWGGG 911
Query: 205 FPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIEIE 264
+ I + L++ + +D WR+ ++ + T D ++
Sbjct: 912 YT---DEPIGKILREIGMSQCVLMDRWRVKVTPNDDVT---------------DDHVD-- 951
Query: 265 GELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGW 324
K V NYFS G+DA +A FH R+ P + + NK+ Y
Sbjct: 952 ---RSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMG----- 1003
Query: 325 FFTPCTSDPGLRGLRNILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNPWGKP 384
D LR RN+ + ++ A++ LN+ SYG G +PW
Sbjct: 1004 -----GKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWN-- 1056
Query: 385 KPEYLEKKGFVEADVADGRLEIFGL 409
+ G + + DG +E+ GL
Sbjct: 1057 -----DSFGASKPSIDDGLMEVVGL 1076
>KDGA_RAT (P51556) Diacylglycerol kinase, alpha (EC 2.7.1.107)
(Diglyceride kinase) (DGK-alpha) (DAG kinase alpha) (80
kDa diacylglycerol kinase)
Length = 727
Score = 129 bits (325), Expect = 1e-29
Identities = 108/397 (27%), Positives = 175/397 (43%), Gaps = 89/397 (22%)
Query: 83 TSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
T P++VFIN +SGG+ G ++ + Q +++ QVF+L D +
Sbjct: 367 THPLLVFINPKSGGKQGQSVLWKFQYILNPRQVFNLKDGPEPGLRFF------------- 413
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
+ + RV+V GGDGTVGW+L + + VPPV ++PLGTGNDL+R WG
Sbjct: 414 ----KDVPQFRVLVCGGDGTVGWILETIDKANF---PIVPPVAVLPLGTGNDLARCLRWG 466
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
+ +++ L+ + V LD W L + +P+
Sbjct: 467 RGYE---GENLRKILKDIEISKVVYLDRWLLEV-IPQQN--------------------- 501
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
GE D V S + NYFSIG+DA +A+ FH +R++ P + + NK+ Y ++ ++
Sbjct: 502 --GEKSDPVPSQ--IINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYLEFATSE 557
Query: 323 GWFFTPCTSDPGLRGLRNILRMHI--KRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNP 380
F T + L + + I K + S+ S+ I LN+ S G N
Sbjct: 558 SIFST-------CKKLEESVTVEICGKLLDLSD-------LSLEGIAVLNIPSMHGGSNL 603
Query: 381 WGKPKPEYLEKKGFVEA-------------------DVADGRLEIFGLKQGWHASFVMVD 421
WG K + + G +A D++D RLE+ G++ +
Sbjct: 604 WGDTKRPHGDTCGINQALGSVAKIITDPDILKTCVPDMSDKRLEVVGIEGVIEMGQIYTR 663
Query: 422 LITAKH-IAQAAAIRLELRGGGWKNAYLQMDGEPWKQ 457
L +A H +A+ + I + K +Q+DGEPW Q
Sbjct: 664 LKSAGHRLAKCSEITFQTT----KTLPMQVDGEPWMQ 696
>KDGA_MOUSE (O88673) Diacylglycerol kinase, alpha (EC 2.7.1.107)
(Diglyceride kinase) (DGK-alpha) (DAG kinase alpha) (80
kDa diacylglycerol kinase)
Length = 730
Score = 129 bits (323), Expect = 2e-29
Identities = 108/397 (27%), Positives = 174/397 (43%), Gaps = 89/397 (22%)
Query: 83 TSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
T P++VFIN +SGG+ G ++ + Q +++ QVFDL D +
Sbjct: 370 THPLLVFINLKSGGKQGQSVLWKFQYILNPRQVFDLKDGPEPGLRFF------------- 416
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
+ + R++V GGDGTVGWVL + + VPPV ++PLGTGNDL+R WG
Sbjct: 417 ----KDVPQFRILVCGGDGTVGWVLETIDKANFA---TVPPVAVLPLGTGNDLARCLRWG 469
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
+ +++ L+ + V LD W L + +P+
Sbjct: 470 RGYE---GENLRKILKDIELSKVVYLDRWFLEV-IPQQN--------------------- 504
Query: 263 IEGELPDKVKSYEGVYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQ 322
GE D V S + NYFSIG+DA +A+ FH +R++ P + + NK+ Y ++ ++
Sbjct: 505 --GEKSDPVPSQ--IINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYFEFATSE 560
Query: 323 GWFFTPCTSDPGLRGLRNILRMHI--KRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNP 380
F T + L + + I K + S+ S+ I LN+ S G N
Sbjct: 561 SIFST-------CKKLEESVTVEICGKLLDLSD-------LSLEGIAVLNIPSTHGGSNL 606
Query: 381 WGKPKPEYLEKKGFVEA-------------------DVADGRLEIFGLKQGWHASFVMVD 421
WG K + + +A D++D RLE+ G++ +
Sbjct: 607 WGDTKRPHGDTCEINQALGSAAKIITDPDILKTCVPDMSDKRLEVVGIEGAIEMGQIYTR 666
Query: 422 LITAKH-IAQAAAIRLELRGGGWKNAYLQMDGEPWKQ 457
L +A H +A+ + I + K +Q+DGEPW Q
Sbjct: 667 LKSAGHRLAKCSEITFQTT----KTLPMQIDGEPWMQ 699
>KDGL_DROME (Q01583) Diacylglycerol kinase (EC 2.7.1.107)
(Diglyceride kinase 1) (DGK 1) (DAG kinase 1)
Length = 791
Score = 96.7 bits (239), Expect = 1e-19
Identities = 77/291 (26%), Positives = 129/291 (43%), Gaps = 42/291 (14%)
Query: 1 MESSPSSTTEDSKKIQVRSSLVESIRGCGLSGMRI----DKEDLKKQLTLPQYLRF---- 52
+E P+S + ++ + RS + GC G +KK+ TL +Y
Sbjct: 39 VEIMPNSFPPEGRRRERRSGNLVLRAGCCCIGKYFLHNRCASSVKKECTLGEYSELIVPP 98
Query: 53 -----AMRDSIRLQDPSAGETLYRNRAEGEDSAAPTSPMVVFINARSGGRHGPALKERLQ 107
A+ D R + + T ++ E S P++VF+N +SGGR G + + Q
Sbjct: 99 TAICPAVLDRQRSVNQAHKATHFQITPPDELSC----PLLVFVNPKSGGRQGDRILRKFQ 154
Query: 108 QLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDSCAKETREKLRVMVAGGDGTVGWVL 167
+++ QV+DL+ P E GL + L + RV+ GGDGTVGWVL
Sbjct: 155 YMLNPRQVYDLSKGGPKE----GLTLFKDLP------------RFRVICCGGDGTVGWVL 198
Query: 168 GCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGGSFPFAWKSAIKRTLQKASVGSVHR 227
+ + + P +G++PLGTGNDL+R WGG + I + + K S
Sbjct: 199 EAMDSIELASQ---PAIGVIPLGTGNDLARCLRWGGGYE---GENIPKLMDKFRRASTVM 252
Query: 228 LDSWRLSI-SMPESTTVKPPYCL--KQAEEFTLDQGIEIEGELPDKVKSYE 275
LD W + + + P S ++P L + L Q + ++ L ++ + +
Sbjct: 253 LDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQ 303
Score = 53.1 bits (126), Expect = 2e-06
Identities = 49/211 (23%), Positives = 84/211 (39%), Gaps = 52/211 (24%)
Query: 280 NYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGWFFTPCTSDPGLRGLR 339
NYFS+G+DA + FH R++ P+ + + NK+ W+F TS+ +
Sbjct: 567 NYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKL----------WYFEYATSETFAASCK 616
Query: 340 NILRMHIKRVSSSEWEQVAIPKSVRAIVALNLHSYGSGRNPWGKPKPEYLEKKGFVEA-- 397
N L I+ V +A ++ + LN+ G N WG E+L +K ++
Sbjct: 617 N-LHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWG----EHLSQKRIRKSAG 671
Query: 398 ------------------------------DVADGRLEIFGLKQGWHASFVMVDL-ITAK 426
D D +E+ GL+ H V L + +
Sbjct: 672 PFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGR 731
Query: 427 HIAQAAAIRLELRGGGWKNAYLQMDGEPWKQ 457
+AQ + + ++ + K +Q+DGEPW Q
Sbjct: 732 RLAQCSEVIIKTK----KTFPMQIDGEPWMQ 758
>KDGD_MESAU (Q64398) Diacylglycerol kinase, delta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130
kDa diacylglycerol kinase) (Diacylglycerol kinase, eta)
Length = 1154
Score = 93.2 bits (230), Expect = 1e-18
Identities = 55/165 (33%), Positives = 86/165 (51%), Gaps = 24/165 (14%)
Query: 84 SPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGDS 143
SP++VF+N++SG G R +QL++ QVFDL + PH GL +
Sbjct: 325 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH----LGLRLFQKF------ 374
Query: 144 CAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWGG 203
+ R++V GGDG+VGWV L+E+ +L +G++PLGTGNDL+R WGG
Sbjct: 375 ------DNFRILVCGGDGSVGWV---LSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGG 425
Query: 204 SFPFAWKSAIKRTLQKASVGSVHRLDSWRL---SISMPESTTVKP 245
S+ + + + L+K S LD W + + +P ++ P
Sbjct: 426 SYDD--DTQLPQILEKLERASTKMLDRWSIMTYELKLPAKASLLP 468
Score = 58.5 bits (140), Expect = 4e-08
Identities = 47/187 (25%), Positives = 78/187 (41%), Gaps = 30/187 (16%)
Query: 277 VYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGWFFTPCTSDPGLR 336
V NYF IG+DA+++ F+ R+E P N + Y G+
Sbjct: 760 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWY------------------GVL 801
Query: 337 GLRNILRMHIKRVS-----SSEWEQVAIPKSVRAIVALNLHSYGSGRNPWGKPKPEYLEK 391
G R +L+ K + + + + +P S++ I LN+ SY G N WG K + +
Sbjct: 802 GTRELLQRSYKNLEQRVQLECDGQYIPLP-SLQGIAVLNIPSYAGGTNFWGGTKEDDI-- 858
Query: 392 KGFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRGGGWKNAYLQMD 451
F D LE+ + + V + IAQ +++ + G + +Q+D
Sbjct: 859 --FAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGD--EGVPVQVD 914
Query: 452 GEPWKQP 458
GE W QP
Sbjct: 915 GEAWVQP 921
>KDGD_HUMAN (Q16760) Diacylglycerol kinase, delta (EC 2.7.1.107)
(Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130
kDa diacylglycerol kinase) (Fragment)
Length = 1195
Score = 88.6 bits (218), Expect = 3e-17
Identities = 57/180 (31%), Positives = 89/180 (48%), Gaps = 23/180 (12%)
Query: 83 TSPMVVFINARSGGRHGPALKERLQQLMSEEQVFDLADVKPHEFVLYGLACLEMLAGLGD 142
TSP++VF+N++SG G R +QL++ QVFDL + PH GL +
Sbjct: 300 TSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH----LGLRLFQKF----- 350
Query: 143 SCAKETREKLRVMVAGGDGTVGWVLGCLTELRQLGREPVPPVGIVPLGTGNDLSRSFNWG 202
+ R++V GGDG+VGWV L+E+ L +G++PLGTGNDL+R WG
Sbjct: 351 -------DTFRILVCGGDGSVGWV---LSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWG 400
Query: 203 GSFPFAWKSAIKRTLQKASVGSVHRLDSWRLSISMPESTTVKPPYCLKQAEEFTLDQGIE 262
+ + + + L+K S LD W S+ E+ + E+F+ D ++
Sbjct: 401 SACDD--DTQLPQILEKLERASTKMLDRW--SVMAYEAKLPRQASSSTVTEDFSEDSEVQ 456
Score = 60.1 bits (144), Expect = 1e-08
Identities = 50/186 (26%), Positives = 75/186 (39%), Gaps = 28/186 (15%)
Query: 277 VYYNYFSIGMDAQVAYGFHRLRDEKPYLASGPIANKIIYSGYSCTQGWFFTPCTSDPGLR 336
V NYF IG+DA+++ F+ RDE P N + Y G+
Sbjct: 744 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWY------------------GVL 785
Query: 337 GLRNILRMHIKRVSSS---EWEQVAIP-KSVRAIVALNLHSYGSGRNPWGKPKPEYLEKK 392
G + +L K + E + IP S++ I LN+ SY G N WG K E
Sbjct: 786 GTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTK----EDD 841
Query: 393 GFVEADVADGRLEIFGLKQGWHASFVMVDLITAKHIAQAAAIRLELRGGGWKNAYLQMDG 452
F D LE+ + + V + IAQ +++ + G + +Q+DG
Sbjct: 842 TFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGD--EGVPVQVDG 899
Query: 453 EPWKQP 458
E W QP
Sbjct: 900 EAWVQP 905
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,160,936
Number of Sequences: 164201
Number of extensions: 2580479
Number of successful extensions: 5615
Number of sequences better than 10.0: 38
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 5475
Number of HSP's gapped (non-prelim): 50
length of query: 482
length of database: 59,974,054
effective HSP length: 114
effective length of query: 368
effective length of database: 41,255,140
effective search space: 15181891520
effective search space used: 15181891520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Medicago: description of AC136954.8