BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC136506.8 - phase: 1
(358 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
FKB7_WHEAT (Q43207) 70 kDa peptidylprolyl isomerase (EC 5.2.1.8)... 132 2e-30
FKB4_RABIT (P27124) FK506-binding protein 4 (EC 5.2.1.8) (Peptid... 112 1e-24
FKB4_HUMAN (Q02790) FK506-binding protein 4 (EC 5.2.1.8) (Peptid... 109 1e-23
FKB4_MOUSE (P30416) FK506-binding protein 4 (EC 5.2.1.8) (Peptid... 107 5e-23
FKB8_HUMAN (Q14318) 38 kDa FK-506 binding protein homolog (FKBPR... 101 3e-21
FKB8_MOUSE (O35465) 38 kDa FK-506 binding protein homolog (FKBPR... 100 7e-21
FKB6_HUMAN (O75344) FK506-binding protein 6 (EC 5.2.1.8) (Peptid... 98 4e-20
FKB5_SAGOE (Q9XSI2) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 95 3e-19
FKB5_HUMAN (Q13451) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 94 5e-19
FKB5_CERAE (Q95L05) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 93 9e-19
FKB5_MOUSE (Q64378) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 92 2e-18
FKB5_AOTNA (Q9XT11) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 92 2e-18
FKB5_SAIBB (Q9XSH5) FK506-binding protein 5 (EC 5.2.1.8) (Peptid... 92 3e-18
FKB6_MOUSE (Q91XW8) FK506-binding protein 6 (EC 5.2.1.8) (Peptid... 91 3e-18
AIP_CERAE (O97628) AH receptor-interacting protein (AIP) (HBV-X ... 82 2e-15
AIP_HUMAN (O00170) AH receptor-interacting protein (AIP) (Immuno... 82 3e-15
AIP_MOUSE (O08915) AH receptor-interacting protein (AIP) 81 4e-15
PPID_HUMAN (Q08752) 40 kDa peptidyl-prolyl cis-trans isomerase (... 76 1e-13
PPID_MOUSE (Q9CR16) 40 kDa peptidyl-prolyl cis-trans isomerase (... 74 4e-13
PPID_BOVIN (P26882) 40 kDa peptidyl-prolyl cis-trans isomerase (... 72 2e-12
>FKB7_WHEAT (Q43207) 70 kDa peptidylprolyl isomerase (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 559
Score = 132 bits (331), Expect = 2e-30
Identities = 90/285 (31%), Positives = 142/285 (49%), Gaps = 7/285 (2%)
Query: 40 EKVTKQIIKEGHG-QKPSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMT 98
+K+ K+++KE G ++P++ + ++ + EQ P E +E +
Sbjct: 274 KKILKKVLKEXEGYERPNEGAVVTVKITGKLQDGTVFLKKGHDEQEPFEFKTDEEAV-IE 332
Query: 99 GLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKAR 158
GL V +MK GE AL+ + E YG S VPP + ++YEVEL+ F + K+
Sbjct: 333 GLDRAVLNMKKGEVALVTIPPEYAYGSTESKQDAIVPPNSTVIYEVELVSFVKDKESW-- 390
Query: 159 SDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALA 218
D+ E+I AA +K +GN LF+ K A ++YE A ++ D F K + L
Sbjct: 391 -DLNNSEKIEAAGTKKEEGNALFKSGKYARASKRYEKAAKFIEYDTSFSEDEKKQSKQLK 449
Query: 219 VKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDF 278
+ C+LN AAC +KL Y++A C+ VL D N+KAL+RR +A L + A D
Sbjct: 450 IT--CNLNNAACKLKLKDYKQAEKLCTKVLELDSRNVKALYRRAQAYTQLADLELAEVDI 507
Query: 279 LKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIFGPRPQP 323
KA + PE++ + K L E K I +K + Y +F +P
Sbjct: 508 KKALEIDPENRDVKLTYKTLKEKIKEINKKDAKFYSNMFSKMTKP 552
Score = 51.2 bits (121), Expect = 4e-06
Identities = 37/126 (29%), Positives = 62/126 (48%), Gaps = 5/126 (3%)
Query: 30 KVDSEVEVLHEKVTKQIIKEGHG-QKPSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEM 88
KV E E+ + + K+++KEG G P HY + + KF+ + +
Sbjct: 31 KVGEENEIGKQGLKKKLLKEGEGWDTPEVGDEVEVHYTGTLLDGK-KFDSSRDRDDTFKF 89
Query: 89 VIGKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIG 148
+G + + + G G+ +MK GE AL + EL YG+ G S P +P A L ++VEL+
Sbjct: 90 KLG-QGQVIKGWDQGIKTMKKGENALFTIPPELAYGESG--SPPTIPANATLQFDVELLS 146
Query: 149 FDETKD 154
+ +D
Sbjct: 147 WTSVRD 152
Score = 36.2 bits (82), Expect = 0.13
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 42 VTKQIIKEGHG-QKPSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGL 100
+ K+I+KEG + P F Y A E+ + E + K+ L
Sbjct: 159 IFKKILKEGDKWENPKDPDEVFVKYEARLEDGT-----VVSKSEGVEFTV-KDGHLCPAL 212
Query: 101 GIGVASMKAGERALLRVSWELGYGQEGSFSFPN---VPPMADLVYEVELIGF 149
V +MK GE+ LL V + G+G+ G + VPP A LV ++EL+ +
Sbjct: 213 AKAVKTMKKGEKVLLAVKPQYGFGEMGRPAAGEGGAVPPNASLVIDLELVSW 264
>FKB4_RABIT (P27124) FK506-binding protein 4 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (p59 protein) (HSP binding immunophilin)
(HBI) (FKBP52 protein) (52 kDa FK506 binding protein)
(FKBP59)
Length = 457
Score = 112 bits (280), Expect = 1e-24
Identities = 73/247 (29%), Positives = 127/247 (50%), Gaps = 8/247 (3%)
Query: 73 EHKFEDTWQEQRPTEMVIGK-EKKEMT-GLGIGVASMKAGERALLRVSWELGYGQEGSFS 130
E ++D +QR +G+ E ++ GL + M+ GE ++L + +G G
Sbjct: 174 EGYYKDRLFDQRELRFEVGEGESLDLPCGLEKAIQRMEKGEHSILYLKPSYAFGNAGKEK 233
Query: 131 FPNVPPMADLVYEVELIGFDETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAM 190
F +PP A+L YEV L F++ K+ +M+ EE++ + K G V F+E K ++A+
Sbjct: 234 F-QIPPYAELKYEVHLKSFEKAKESW---EMSSEEKLEQSAIVKERGTVYFKEGKYKQAL 289
Query: 191 QQYEMAIAYMGDDFMFQLFGKYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSE 250
QY+ ++++ + F + A A++ HLN A C +KL + A+ C+ L
Sbjct: 290 LQYKKIVSWLEYESSFS--SEEVQKAQALRLASHLNLAMCHLKLQAFSAAVESCNKALEL 347
Query: 251 DESNLKALFRRGKARAALGQTDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQK 310
D +N K LFRRG+A A+ D AR DF K + P +KA +L + + + ++K
Sbjct: 348 DSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKAQLAVCQQRIRKQIAREK 407
Query: 311 EIYKGIF 317
++Y +F
Sbjct: 408 KLYANMF 414
Score = 51.6 bits (122), Expect = 3e-06
Identities = 56/192 (29%), Positives = 80/192 (41%), Gaps = 22/192 (11%)
Query: 6 DEVIDENSEYEKGETPEELLSSPPKVDSEVEVLHEKVTKQIIKEGHG-QKPSKYSTCFFH 64
+E+ S + P E + PK D E V K I +EG G + P F H
Sbjct: 3 EEMKAAESGAQSAPLPLEGVDISPKQD-------EGVLKVIKREGTGTETPMIGDRVFVH 55
Query: 65 YRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLGIGVASMKAGERALLRVSWELGYG 124
Y W + KF+ + + +GK + + I VA+MK GE + E YG
Sbjct: 56 YTGWLLDGT-KFDSSLDRKDKFSFDLGKGEV-IKAWDIAVATMKVGELCRITCKPEYAYG 113
Query: 125 QEGSFSFPNVPPMADLVYEVELIGFDETKDGKARSDMTVEERIGAADRRKMDGNVLFQEN 184
GS P +PP A LV+EVEL F D+T +E G R + G + N
Sbjct: 114 SAGSP--PKIPPNATLVFEVELFEF-------KGEDLTDDEDGGIIRRIRTRGEGYARPN 164
Query: 185 K---LEEAMQQY 193
+E A++ Y
Sbjct: 165 DGAIVEVALEGY 176
>FKB4_HUMAN (Q02790) FK506-binding protein 4 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (p59 protein) (HSP binding immunophilin)
(HBI) (FKBP52 protein) (52 kDa FK506 binding protein)
(FKBP59)
Length = 458
Score = 109 bits (272), Expect = 1e-23
Identities = 72/247 (29%), Positives = 126/247 (50%), Gaps = 8/247 (3%)
Query: 73 EHKFEDTWQEQRPTEMVIGK-EKKEMT-GLGIGVASMKAGERALLRVSWELGYGQEGSFS 130
E ++D +QR IG+ E ++ GL + M+ GE +++ + +G G
Sbjct: 174 EGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEK 233
Query: 131 FPNVPPMADLVYEVELIGFDETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAM 190
F +PP A+L YE+ L F++ K+ +M EE++ + K G V F+E K ++A+
Sbjct: 234 F-QIPPNAELKYELHLKSFEKAKESW---EMNSEEKLEQSTIVKERGTVYFKEGKYKQAL 289
Query: 191 QQYEMAIAYMGDDFMFQLFGKYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSE 250
QY+ ++++ + F + A A++ HLN A C +KL + AI C+ L
Sbjct: 290 LQYKKIVSWLEYESSFS--NEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALEL 347
Query: 251 DESNLKALFRRGKARAALGQTDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQK 310
D +N K LFRRG+A A+ + AR DF K + P +KA +L + + + ++K
Sbjct: 348 DSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREK 407
Query: 311 EIYKGIF 317
++Y +F
Sbjct: 408 KLYANMF 414
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/192 (29%), Positives = 81/192 (42%), Gaps = 22/192 (11%)
Query: 6 DEVIDENSEYEKGETPEELLSSPPKVDSEVEVLHEKVTKQIIKEGHG-QKPSKYSTCFFH 64
+E+ S + P E + PK D E V K I +EG G + P F H
Sbjct: 3 EEMKATESGAQSAPLPMEGVDISPKQD-------EGVLKVIKREGTGTEMPMIGDRVFVH 55
Query: 65 YRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLGIGVASMKAGERALLRVSWELGYG 124
Y W + KF+ + + +GK + + I +A+MK GE + E YG
Sbjct: 56 YTGWLLDGT-KFDSSLDRKDKFSFDLGKGEV-IKAWDIAIATMKVGEVCHITCKPEYAYG 113
Query: 125 QEGSFSFPNVPPMADLVYEVELIGFDETKDGKARSDMTVEERIGAADRRKMDGNVLFQEN 184
GS P +PP A LV+EVEL F D+T EE G R + G + N
Sbjct: 114 SAGSP--PKIPPNATLVFEVELFEF-------KGEDLTEEEDGGIIRRIQTRGEGYAKPN 164
Query: 185 K---LEEAMQQY 193
+ +E A++ Y
Sbjct: 165 EGAIVEVALEGY 176
>FKB4_MOUSE (P30416) FK506-binding protein 4 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (p59 protein) (HSP binding immunophilin)
(HBI) (FKBP52 protein) (52 kDa FK506 binding protein)
(FKBP59)
Length = 457
Score = 107 bits (267), Expect = 5e-23
Identities = 65/219 (29%), Positives = 113/219 (50%), Gaps = 6/219 (2%)
Query: 99 GLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKAR 158
GL + M+ GE +++ + +G G F +PP A+L YEV L F++ K+
Sbjct: 202 GLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERF-QIPPHAELRYEVRLKSFEKAKESW-- 258
Query: 159 SDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALA 218
+M+ E++ ++ K G F+E K ++A+ QY+ ++++ + F G+ A
Sbjct: 259 -EMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFS--GEEMQKVHA 315
Query: 219 VKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDF 278
++ HLN A C +KL + AI C+ L D +N K LFRRG+A A+ D AR DF
Sbjct: 316 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADF 375
Query: 279 LKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
K + P +KA +L + + + ++K++Y +F
Sbjct: 376 QKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMF 414
Score = 54.3 bits (129), Expect = 5e-07
Identities = 81/291 (27%), Positives = 119/291 (40%), Gaps = 58/291 (19%)
Query: 21 PEELLSSPPKVDSEVEVLHEKVTKQIIKEGHG-QKPSKYSTCFFHYRAWSENTEHKFEDT 79
P E + PK D E V K I +EG G + P F HY W + KF+ +
Sbjct: 18 PLEGVDISPKQD-------EGVLKVIKREGTGTETPMIGDRVFVHYTGWLLDGT-KFDSS 69
Query: 80 WQEQRPTEMVIGKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMAD 139
+ +GK + + I VA+MK GE + E YG GS P +PP A
Sbjct: 70 LDRKDKFSFDLGKGEV-IKAWDIAVATMKVGEVCHITCKPEYAYGAAGSP--PKIPPNAT 126
Query: 140 LVYEVELIGF-----DETKDG------KARSDMTVEERIGAA--------------DRRK 174
LV+EVEL F E +DG + R + GA D+R+
Sbjct: 127 LVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYHKDRLFDQRE 186
Query: 175 M-----DGNVLFQENKLEEAMQQYEM---AIAYMGDDFMFQLFGKYRDMALAVKNPCHLN 226
+ +G L LEEA+Q+ E +I Y+ + F GK R + P H
Sbjct: 187 LCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKER-----FQIPPHAE 241
Query: 227 TAACLIKLNRYEEAIGQCSIVLSE--DESNL-----KALFRRGKARAALGQ 270
++L +E+A + +E ++SN+ A F+ GK + AL Q
Sbjct: 242 -LRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQ 291
>FKB8_HUMAN (Q14318) 38 kDa FK-506 binding protein homolog (FKBPR38)
(FK506-binding protein 8)
Length = 355
Score = 101 bits (252), Expect = 3e-21
Identities = 75/242 (30%), Positives = 108/242 (43%), Gaps = 9/242 (3%)
Query: 100 LGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKARS 159
L + V M GE A++ + YG +G P +PP A L EV L DG
Sbjct: 99 LDLSVPLMDVGETAMVTADSKYCYGPQGRS--PYIPPHAALCLEVTL---KTAVDGPDLE 153
Query: 160 DMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAV 219
+T +ER+ A+R++ GN +Q A Y++AI + + + L +
Sbjct: 154 MLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQL 213
Query: 220 KNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFL 279
K C N AA +KL+ Y A+ CS+VL N+KALFR+GK A G+ A
Sbjct: 214 KVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILR 273
Query: 280 KARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIFG---PRPQPVPQKRNWFIVVWQ 336
A K P +K I EL L + A + +Y+ + G P P K W I W+
Sbjct: 274 AALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSI-PWK 332
Query: 337 WL 338
WL
Sbjct: 333 WL 334
>FKB8_MOUSE (O35465) 38 kDa FK-506 binding protein homolog (FKBPR38)
(FK506-binding protein 8) (muFKBP38)
Length = 355
Score = 100 bits (248), Expect = 7e-21
Identities = 74/242 (30%), Positives = 110/242 (44%), Gaps = 9/242 (3%)
Query: 100 LGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKARS 159
L + V M GE A++ + YG +G P +PP A L EV L +DG
Sbjct: 99 LDLSVPLMDVGETAMVTADSKYCYGPQGRS--PYIPPHAALCLEVTL---KTAEDGPDLE 153
Query: 160 DMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAV 219
++ +ER+ A+R++ GN +Q A Y++AI + + + + + L +
Sbjct: 154 MLSGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSNTKVDMTCEEEEELLQL 213
Query: 220 KNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFL 279
K C N AA +KL+ Y A+ CS VL N+KALFR+GK A G+ A
Sbjct: 214 KVKCLNNLAASQLKLDHYRAALRSCSQVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILR 273
Query: 280 KARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIFG---PRPQPVPQKRNWFIVVWQ 336
A K P +K I EL L + A + +Y+ + G P P K W I W+
Sbjct: 274 AALKLEPSNKTIHAELSKLVKKRAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSI-PWK 332
Query: 337 WL 338
WL
Sbjct: 333 WL 334
>FKB6_HUMAN (O75344) FK506-binding protein 6 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (36 kDa FK506 binding protein) (FKBP-36)
(Immunophilin FKBP36)
Length = 327
Score = 97.8 bits (242), Expect = 4e-20
Identities = 76/286 (26%), Positives = 135/286 (46%), Gaps = 14/286 (4%)
Query: 42 VTKQIIKEGHGQKPSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLG 101
V K +I+EG G + ++ Y + E+ + F+ + + P M +G E + G+
Sbjct: 38 VLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLG-EDITLWGME 96
Query: 102 IGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKARSDM 161
+G+ SM+ GE A YG G P +PP +++E+EL+ F + + +
Sbjct: 97 LGLLSMRRGELARFLFKPNYAYGTLGCP--PLIPPNTTVLFEIELLDFLDCAESDKFCAL 154
Query: 162 TVEER--------IGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYR 213
+ E++ + A + GN LF++N+ +A +Y+ A+ + + +
Sbjct: 155 SAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRR---SAPPEEQ 211
Query: 214 DMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDA 273
+ A K P LN + +KL+R A+ L D+ N KALFR G+A L +
Sbjct: 212 HLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQK 271
Query: 274 AREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIFGP 319
AR+ ++A+K P + I ELK LA + K+KE++ +F P
Sbjct: 272 ARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAP 317
>FKB5_SAGOE (Q9XSI2) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (51 kDa
FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/227 (26%), Positives = 115/227 (50%), Gaps = 6/227 (2%)
Query: 91 GKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFD 150
G++ G+ + M+ E+ +L + G+G+ G F + P A+L+YEV L F+
Sbjct: 193 GEDHDIPIGIDKALEKMQREEQCILHLGPRYGFGEAGKPKF-GIEPNAELIYEVTLKSFE 251
Query: 151 ETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG 210
+ K+ +M +E++ A K +G V F+ K +A+ QY ++++ + + L
Sbjct: 252 KAKESW---EMDTKEKLEQAAIVKEEGTVYFKGGKYVQAVIQYGKIVSWL--EMEYGLSE 306
Query: 211 KYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQ 270
K + + LN A C +KL Y +A+ C L D +N K L+RRG+A+ + +
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYAKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 271 TDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
++A+ DF K + P++KA ++ + + K ++ + IY +F
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQIVVCQKKAKEHNERDRRIYANMF 413
Score = 51.6 bits (122), Expect = 3e-06
Identities = 58/202 (28%), Positives = 84/202 (40%), Gaps = 36/202 (17%)
Query: 42 VTKQIIKEGHGQK-PSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGL 100
V K + + GHG++ P + HY N + KF+ + P IGK + +
Sbjct: 33 VLKIVKRVGHGEETPMIGDKVYVHYNGKLSNGK-KFDSSHDRNEPFVFSIGKGQV-IKAW 90
Query: 101 GIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGF---DETKDG-- 155
IGV++MK GE L E YG GS P +P A L +EVEL+ F D +DG
Sbjct: 91 DIGVSTMKKGEICHLLCKPEYAYGATGSL--PKIPSNATLFFEVELLNFKGEDLLEDGGI 148
Query: 156 ----------------KARSDMTVEERIGAA--DRRKM--------DGNVLFQENKLEEA 189
AR + +E R G D R + D ++ +K E
Sbjct: 149 IRRTKRRGEGYSNPNEGARVQIHLEGRCGGRVFDCRDVAFTVGEGEDHDIPIGIDKALEK 208
Query: 190 MQQYEMAIAYMGDDFMFQLFGK 211
MQ+ E I ++G + F GK
Sbjct: 209 MQREEQCILHLGPRYGFGEAGK 230
>FKB5_HUMAN (Q13451) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (51 kDa FK506-binding protein) (FKBP-51) (54
kDa progesterone receptor-associated immunophilin)
(FKBP54) (P54) (FF1 antigen) (HSP90-binding
Length = 457
Score = 94.0 bits (232), Expect = 5e-19
Identities = 60/227 (26%), Positives = 114/227 (49%), Gaps = 6/227 (2%)
Query: 91 GKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFD 150
G++ G+ + M+ E+ +L + G+G+ G F + P A+L+YEV L F+
Sbjct: 193 GEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKF-GIEPNAELIYEVTLKSFE 251
Query: 151 ETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG 210
+ K+ +M +E++ A K G V F+ K +A+ QY ++++ + + L
Sbjct: 252 KAKESW---EMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWL--EMEYGLSE 306
Query: 211 KYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQ 270
K + + LN A C +KL Y +A+ C L D +N K L+RRG+A+ + +
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 271 TDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
++A+ DF K + P++KA ++ + + K ++ + IY +F
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMF 413
Score = 49.7 bits (117), Expect = 1e-05
Identities = 56/202 (27%), Positives = 85/202 (41%), Gaps = 36/202 (17%)
Query: 42 VTKQIIKEGHGQK-PSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGL 100
V K + + G+G++ P + HY+ N + KF+ + P +GK + +
Sbjct: 33 VLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGK-KFDSSHDRNEPFVFSLGKGQV-IKAW 90
Query: 101 GIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGF---DETKDG-- 155
IGVA+MK GE L E YG G S P +P A L +E+EL+ F D +DG
Sbjct: 91 DIGVATMKKGEICHLLCKPEYAYGSAG--SLPKIPSNATLFFEIELLDFKGEDLFEDGGI 148
Query: 156 ----------------KARSDMTVEERIGAA--DRRKM--------DGNVLFQENKLEEA 189
A ++ +E R G D R + D ++ +K E
Sbjct: 149 IRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEK 208
Query: 190 MQQYEMAIAYMGDDFMFQLFGK 211
MQ+ E I Y+G + F GK
Sbjct: 209 MQREEQCILYLGPRYGFGEAGK 230
>FKB5_CERAE (Q95L05) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (51 kDa
FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 93.2 bits (230), Expect = 9e-19
Identities = 60/227 (26%), Positives = 113/227 (49%), Gaps = 6/227 (2%)
Query: 91 GKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFD 150
G++ G+ + M+ E+ +L + G+G+ G F + P A+L+YEV L F+
Sbjct: 193 GEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKF-GIEPNAELIYEVTLKSFE 251
Query: 151 ETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG 210
+ K+ +M +E++ A K G V F+ K A+ QY ++++ + + L
Sbjct: 252 KAKESW---EMDTKEKLEQAAIVKEKGTVYFKGGKYMRAVIQYGKIVSWL--EMEYGLSE 306
Query: 211 KYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQ 270
K + + LN A C +KL Y +A+ C L D +N K L+RRG+A+ + +
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 271 TDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
++A+ DF K + P++KA ++ + + K ++ + IY +F
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMF 413
Score = 49.3 bits (116), Expect = 1e-05
Identities = 54/202 (26%), Positives = 80/202 (38%), Gaps = 36/202 (17%)
Query: 42 VTKQIIKEGHGQK-PSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGL 100
V K + + G+G++ P + HY+ N + KF + P +GK + +
Sbjct: 33 VLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGK-KFNSSHDRNEPFVFSLGKSQV-IKAW 90
Query: 101 GIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGF---DETKDG-- 155
IGVA+MK GE L E YG G S P +P A L +E+EL+ F D +DG
Sbjct: 91 DIGVATMKKGEICHLLCKPEYAYGSAG--SVPKIPSNATLFFEIELLDFKGEDLLEDGGI 148
Query: 156 ------------KARSDMTVEERIGAADRRKM--------------DGNVLFQENKLEEA 189
TVE + +M D ++ +K E
Sbjct: 149 IRRTKRKGEGYSNPNEGATVEIHLEGRCGERMFDCRDVAFTVGEGEDHDIPIGIDKALEK 208
Query: 190 MQQYEMAIAYMGDDFMFQLFGK 211
MQ+ E I Y+G + F GK
Sbjct: 209 MQREEQCILYLGPRYGFGEAGK 230
>FKB5_MOUSE (Q64378) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (51 kDa FK506-binding protein) (FKBP-51)
Length = 456
Score = 92.4 bits (228), Expect = 2e-18
Identities = 62/236 (26%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 84 RPTEMVIGKEKKEMTGLGIGVA--SMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLV 141
R V+G+ + +GI A M+ E+ +L + G+G+ G F + P A+L+
Sbjct: 184 RDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKF-GIDPNAELM 242
Query: 142 YEVELIGFDETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMG 201
YEV L F++ K+ +M +E++ A K G V F+ K +A+ QY ++++
Sbjct: 243 YEVTLKSFEKAKESW---EMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWL- 298
Query: 202 DDFMFQLFGKYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRR 261
+ + L K + + LN A C +KL Y +A+ C L D +N K L+RR
Sbjct: 299 -EMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRR 357
Query: 262 GKARAALGQTDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
G+A+ + ++A+ DF K P+++A ++ + K ++ + +Y +F
Sbjct: 358 GEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMF 413
Score = 38.5 bits (88), Expect = 0.026
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 4/88 (4%)
Query: 62 FFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLGIGVASMKAGERALLRVSWEL 121
+ HY+ + + KF+ + ++P +G + + + IGV++MK GE L E
Sbjct: 54 YVHYKGMLSDGK-KFDSSHDRKKPFAFSLG-QGQVIKAWDIGVSTMKKGEICHLLCKPEY 111
Query: 122 GYGQEGSFSFPNVPPMADLVYEVELIGF 149
YG G +P A L +E+EL+ F
Sbjct: 112 AYGSAGHLQ--KIPSNATLFFEIELLDF 137
>FKB5_AOTNA (Q9XT11) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (51 kDa
FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 92.4 bits (228), Expect = 2e-18
Identities = 59/227 (25%), Positives = 114/227 (49%), Gaps = 6/227 (2%)
Query: 91 GKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFD 150
G++ G+ + M+ E+ +L + G+G+ G F + P A+L+YEV L F+
Sbjct: 193 GEDHDIPIGIDKALEKMQREEQCILHLGPRYGFGEAGKPKF-GIEPNAELIYEVTLKSFE 251
Query: 151 ETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG 210
+ K+ +M +E++ A K G + F+ K +A+ QY ++++ + + L
Sbjct: 252 KAKESW---EMDTKEKLEQAAIVKEKGTLYFKGGKYVQAVIQYGKIVSWL--EMEYGLSE 306
Query: 211 KYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQ 270
K + + LN A C +KL Y +A+ C L D +N K L+RRG+A+ + +
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 271 TDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
++A+ DF K + P++KA ++ + + K ++ + IY +F
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQIFMCQKKAKEHNERDRRIYANMF 413
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/202 (28%), Positives = 84/202 (40%), Gaps = 36/202 (17%)
Query: 42 VTKQIIKEGHGQK-PSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGL 100
V K + + GHG++ P + HY N + KF+ + P IGK + +
Sbjct: 33 VLKIVKRVGHGEETPMIGDKVYVHYNGKLSNGK-KFDSSHDRNEPFVFSIGKGQV-IKAW 90
Query: 101 GIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGF---DETKDG-- 155
IGVA+MK GE L E YG G S P +P A L +E+EL+ F D +DG
Sbjct: 91 DIGVATMKKGEICHLLCKPEYAYGATG--SLPKIPSNATLFFEIELLDFKGEDLLEDGGI 148
Query: 156 ----------------KARSDMTVEERIGAA--DRRKM--------DGNVLFQENKLEEA 189
AR + +E R G D R + D ++ +K E
Sbjct: 149 IRRTKRRGEGYSNPNEGARVQIHLEGRCGGRVFDCRDVAFTVGEGEDHDIPIGIDKALEK 208
Query: 190 MQQYEMAIAYMGDDFMFQLFGK 211
MQ+ E I ++G + F GK
Sbjct: 209 MQREEQCILHLGPRYGFGEAGK 230
>FKB5_SAIBB (Q9XSH5) FK506-binding protein 5 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (51 kDa
FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 91.7 bits (226), Expect = 3e-18
Identities = 59/227 (25%), Positives = 113/227 (48%), Gaps = 6/227 (2%)
Query: 91 GKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFD 150
G++ G+ + M+ E+ +L + G+G+ G F + P A+L+YEV L F+
Sbjct: 193 GEDHDIPIGIDKALEKMQREEQCILHLGPRYGFGEAGKPKF-GIEPNAELIYEVTLKSFE 251
Query: 151 ETKDGKARSDMTVEERIGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG 210
+ K+ +M +E++ A K G V F+ K +A+ QY ++++ + + L
Sbjct: 252 KAKESW---EMDTKEKLEQAAIVKEKGTVYFKGGKYVQAVIQYGKIVSWL--EMEYGLSE 306
Query: 211 KYRDMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQ 270
K + + LN A C +KL Y +A+ C L D +N K L+RRG+A+ + +
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 271 TDAAREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIF 317
++A+ DF K + P++KA ++ + + K ++ + Y +F
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQIFMCQKKAKEHNERDRRTYANMF 413
Score = 53.5 bits (127), Expect = 8e-07
Identities = 64/234 (27%), Positives = 96/234 (40%), Gaps = 39/234 (16%)
Query: 10 DENSEYEKGETPEELLSSPPKVDSEVEVLHEKVTKQIIKEGHGQK-PSKYSTCFFHYRAW 68
DE ++ +G + V S+ + K+ K++ GHG++ P + HY
Sbjct: 4 DEGAKNSRGNPAATVAEQGEDVTSKKDRGVLKIVKRV---GHGEETPMIGDRVYVHYNGK 60
Query: 69 SENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLGIGVASMKAGERALLRVSWELGYGQEGS 128
N + KF+ + P IGK + + IGVA+MK GE L E YG G
Sbjct: 61 LANGK-KFDSSHDRNEPFVFSIGKGQV-IKAWDIGVATMKKGEICHLLCKPEYAYGATG- 117
Query: 129 FSFPNVPPMADLVYEVELIGF---DETKDG------------------KARSDMTVEERI 167
S P +P A L +EVEL+ F D +DG AR + +E R
Sbjct: 118 -SLPKIPSNATLFFEVELLDFKGEDLLEDGGIIRRTKRRGEGYSNPNEGARVQIHLEGRC 176
Query: 168 GAA--DRRKM--------DGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGK 211
G D R + D ++ +K E MQ+ E I ++G + F GK
Sbjct: 177 GGRVFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILHLGPRYGFGEAGK 230
>FKB6_MOUSE (Q91XW8) FK506-binding protein 6 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (36 kDa FK506 binding protein) (FKBP-36)
(Immunophilin FKBP36)
Length = 327
Score = 91.3 bits (225), Expect = 3e-18
Identities = 75/286 (26%), Positives = 135/286 (46%), Gaps = 14/286 (4%)
Query: 42 VTKQIIKEGHGQKPSKYSTCFFHYRAWSENTEHKFEDTWQEQRPTEMVIGKEKKEMTGLG 101
V K II+EG G + ++ Y + E+ + F+ + P M +G E + G+
Sbjct: 38 VLKDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLG-EDITLWGME 96
Query: 102 IGVASMKAGERALLRVSWELGYGQEGSFSFPNVPPMADLVYEVELIGFDETKDGKARSDM 161
+G+ SM+ GE A YG G P +PP A +++E+ELI F ++ + +
Sbjct: 97 LGLLSMRKGELARFLFKPAYAYGTLGCP--PLIPPNATVLFEIELIDFLDSAESDKFCAL 154
Query: 162 TVEER--------IGAADRRKMDGNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYR 213
+ E++ + A + GN LF++N+ +A +Y+ A+ +
Sbjct: 155 SAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLATCEEQHLV 214
Query: 214 DMALAVKNPCHLNTAACLIKLNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDA 273
+ A+ + LN + +KL+R A+ L D+ N KALFR G+A L + +
Sbjct: 215 EPAVLL---VLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYER 271
Query: 274 AREDFLKARKHAPEDKAIARELKLLAEHDKAIYQKQKEIYKGIFGP 319
AR+ ++A+K P + I ELK L+ H + +++E+ +F P
Sbjct: 272 ARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAP 317
>AIP_CERAE (O97628) AH receptor-interacting protein (AIP) (HBV-X
associated protein 2) (P38)
Length = 330
Score = 82.4 bits (202), Expect = 2e-15
Identities = 85/319 (26%), Positives = 142/319 (43%), Gaps = 46/319 (14%)
Query: 42 VTKQIIKEGHGQKPSKY--STCFFHYRAW-SENTEHKFEDTWQEQRPTEMVIGKEKKEMT 98
+ K++I+EG G+ P + FHYR S+N +D+ +P E++IGK+ K
Sbjct: 13 IQKRVIQEGRGELPDFQDGTKATFHYRTLHSDNEGTVLDDSRVRGKPMELIIGKKFKLPV 72
Query: 99 GLGIGVASMKAGERA--------------LLRVSWELGYGQ---EGSFSFPNVPPMAD-- 139
I V +M+ GE A + + + G+ EG V M +
Sbjct: 73 WETI-VCTMREGEIAQFLCDIKHVVLYPLVAKSLGNIAVGKDPLEGQRHCCGVAQMHEHS 131
Query: 140 ----------------LVYEVELIGFDETKDGKARSD---MTVEERIGAADRRKMDGNVL 180
LV+ +E++ + G + D MT EE+ A +GN L
Sbjct: 132 SLGHADLDALQQNPQPLVFHMEMLKVESP--GTYQQDPWAMTDEEKAKAVPLIHQEGNRL 189
Query: 181 FQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAVK-NPCHLNTAACLIKLNRYEE 239
++E ++EA +Y AIA + + M + G + L + P LN C + Y E
Sbjct: 190 YREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVAEEYYE 249
Query: 240 AIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPE-DKAIARELKLL 298
+ CS +L++ + N+KA F+RGKA AA+ A+ DF K + P ++REL+ L
Sbjct: 250 VLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Query: 299 AEHDKAIYQKQKEIYKGIF 317
+ ++ K ++GIF
Sbjct: 310 EARIRQKDEEDKARFRGIF 328
>AIP_HUMAN (O00170) AH receptor-interacting protein (AIP)
(Immunophilin homolog ARA9) (HBV-X associated protein 2)
Length = 330
Score = 81.6 bits (200), Expect = 3e-15
Identities = 83/319 (26%), Positives = 142/319 (44%), Gaps = 46/319 (14%)
Query: 42 VTKQIIKEGHGQKPSKY--STCFFHYRAWSENTEHK-FEDTWQEQRPTEMVIGKEKKEMT 98
+ K++I+EG G+ P + FHYR + E +D+ +P E++IGK+ K
Sbjct: 13 IQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPV 72
Query: 99 GLGIGVASMKAGERA--------------LLRVSWELGYGQ---EGSFSFPNVPPMAD-- 139
I V +M+ GE A + + + G+ EG V M +
Sbjct: 73 WETI-VCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHS 131
Query: 140 ----------------LVYEVELIGFDETKDGKARSD---MTVEERIGAADRRKMDGNVL 180
L++ +E++ + G + D MT EE+ A +GN L
Sbjct: 132 SLGHADLDALQQNPQPLIFHMEMLKVESP--GTYQQDPWAMTDEEKAKAVPLIHQEGNRL 189
Query: 181 FQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAVK-NPCHLNTAACLIKLNRYEE 239
++E ++EA +Y AIA + + M + G + L + P LN C + + Y E
Sbjct: 190 YREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDKQITPLLLNYCQCKLVVEEYYE 249
Query: 240 AIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPE-DKAIARELKLL 298
+ CS +L++ + N+KA F+RGKA AA+ A+ DF K + P ++REL+ L
Sbjct: 250 VLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Query: 299 AEHDKAIYQKQKEIYKGIF 317
+ ++ K ++GIF
Sbjct: 310 EARIRQKDEEDKARFRGIF 328
>AIP_MOUSE (O08915) AH receptor-interacting protein (AIP)
Length = 330
Score = 81.3 bits (199), Expect = 4e-15
Identities = 83/319 (26%), Positives = 142/319 (44%), Gaps = 46/319 (14%)
Query: 42 VTKQIIKEGHGQKPSKY--STCFFHYRAW-SENTEHKFEDTWQEQRPTEMVIGKEKKEMT 98
+ K++I+EG G+ P + FH+R S+N +D+ +P E+++GK+ K
Sbjct: 13 IQKRVIQEGRGELPDFQDGTKATFHFRTLHSDNEGSVIDDSRTRGKPMELIVGKKFKLPV 72
Query: 99 GLGIGVASMKAGERAL-----------------LRVSWELGYGQEGSFSFPNVPPMAD-- 139
I V +M+ GE A LR E EG + M +
Sbjct: 73 WETI-VCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHS 131
Query: 140 ----------------LVYEVELIGFDETKDGKARSD---MTVEERIGAADRRKMDGNVL 180
L++ +E++ + G + D MT EE+ A +GN L
Sbjct: 132 SLGHADLDALQQNPQPLIFHIEMLKVESP--GTYQQDPWAMTDEEKAKAVPVIHQEGNRL 189
Query: 181 FQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAVK-NPCHLNTAACLIKLNRYEE 239
++E +++EA +Y AIA + + M + G + L ++ P LN C + Y E
Sbjct: 190 YREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYE 249
Query: 240 AIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPE-DKAIARELKLL 298
+ CS +L++ + N+KA F+RGKA AA+ A+ DF K + P ++REL+ L
Sbjct: 250 VLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Query: 299 AEHDKAIYQKQKEIYKGIF 317
+ ++ K ++GIF
Sbjct: 310 ETRIRQKDEEDKARFRGIF 328
>PPID_HUMAN (Q08752) 40 kDa peptidyl-prolyl cis-trans isomerase (EC
5.2.1.8) (PPIase) (Rotamase) (Cyclophilin-40) (CYP-40)
(Cyclophilin-related protein)
Length = 369
Score = 75.9 bits (185), Expect = 1e-13
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 1/141 (0%)
Query: 177 GNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAVKNPCHLNTAACLIKLNR 236
GN F+ E A+++Y + Y+ D + R + C LN AC +K++
Sbjct: 229 GNTFFKSQNWEMAIKKYAEVLRYV-DSSKAVIETADRAKLQPIALSCVLNIGACKLKMSN 287
Query: 237 YEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPEDKAIARELK 296
++ AI C L D SN KAL+RR + L + D A D KA+ APEDKAI EL
Sbjct: 288 WQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELL 347
Query: 297 LLAEHDKAIYQKQKEIYKGIF 317
+ + KA K+K +Y +F
Sbjct: 348 KVKQKIKAQKDKEKAVYAKMF 368
>PPID_MOUSE (Q9CR16) 40 kDa peptidyl-prolyl cis-trans isomerase (EC
5.2.1.8) (PPIase) (Rotamase) (Cyclophilin-40) (CYP-40)
Length = 369
Score = 74.3 bits (181), Expect = 4e-13
Identities = 46/141 (32%), Positives = 70/141 (49%), Gaps = 1/141 (0%)
Query: 177 GNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFGKYRDMALAVKNPCHLNTAACLIKLNR 236
GN F+ E A+++Y + Y+ D + R + C LN AC +K++
Sbjct: 229 GNTFFKSQNWEMAIKKYAKVLRYV-DSSKAVIEKADRSRLQPIALSCVLNIGACKLKMSN 287
Query: 237 YEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPEDKAIARELK 296
++ AI C L D SN KAL+R+ + L + D A D KA++ AP DKAI EL
Sbjct: 288 WQGAIDSCLEALEMDPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGDKAIQAELL 347
Query: 297 LLAEHDKAIYQKQKEIYKGIF 317
+ + KA K+K +Y +F
Sbjct: 348 KVKQMIKAQKDKEKAVYAKMF 368
>PPID_BOVIN (P26882) 40 kDa peptidyl-prolyl cis-trans isomerase (EC
5.2.1.8) (PPIase) (Rotamase) (Cyclophilin-40) (CYP-40)
(Cyclophilin-related protein) (Estrogen receptor binding
cyclophilin)
Length = 369
Score = 72.0 bits (175), Expect = 2e-12
Identities = 48/144 (33%), Positives = 72/144 (49%), Gaps = 7/144 (4%)
Query: 177 GNVLFQENKLEEAMQQYEMAIAYMGDDFMFQLFG---KYRDMALAVKNPCHLNTAACLIK 233
GN F+ E A+++Y + Y+ K + +AL+ C LN AC +K
Sbjct: 229 GNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALS----CVLNIGACKLK 284
Query: 234 LNRYEEAIGQCSIVLSEDESNLKALFRRGKARAALGQTDAAREDFLKARKHAPEDKAIAR 293
++ ++ A+ C L D SN KAL+RR + L + D A D KA++ APEDKAI
Sbjct: 285 MSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQA 344
Query: 294 ELKLLAEHDKAIYQKQKEIYKGIF 317
EL + + KA K+K Y +F
Sbjct: 345 ELLKVKQKIKAQKDKEKAAYAKMF 368
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,608,038
Number of Sequences: 164201
Number of extensions: 1946306
Number of successful extensions: 5585
Number of sequences better than 10.0: 155
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 5389
Number of HSP's gapped (non-prelim): 215
length of query: 358
length of database: 59,974,054
effective HSP length: 111
effective length of query: 247
effective length of database: 41,747,743
effective search space: 10311692521
effective search space used: 10311692521
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Medicago: description of AC136506.8