BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC136451.2 - phase: 0 /pseudo
(355 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
C90C_ARATH (Q9M066) Cytochrome P450 90C1 (EC 1.14.-.-) (ROTUNDIF... 248 1e-65
C901_ARATH (Q42569) Cytochrome P450 90A1 (EC 1.14.-.-) 141 3e-33
CP85_LYCES (Q43147) Cytochrome P450 85 (EC 1.14.-.-) (Dwarf prot... 111 2e-24
KAO1_HORVU (Q9AXH9) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)... 91 6e-18
C881_MAIZE (Q43246) Cytochrome P450 88A1 (EC 1.14.-.-) (Dwarf3 p... 88 4e-17
KAO1_ARATH (O23051) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)... 86 1e-16
T10H_TAXCU (Q9AXM6) Taxane 10-beta-hydroxylase (EC 1.14.13.76) (... 85 3e-16
KAO2_ARATH (Q9C5Y2) Ent-kaurenoic acid oxidase 2 (EC 1.14.13.79)... 79 2e-14
CPCD_RAT (P20814) Cytochrome P450 2C13, male-specific (EC 1.14.1... 73 1e-12
CPCU_RABIT (Q29510) Cytochrome P450 2C30 (EC 1.14.14.1) (CYPIIC30) 73 1e-12
CPZ4_MOUSE (P56656) Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39) 72 2e-12
C6B6_HELAM (Q95031) Cytochrome P450 6B6 (EC 1.14.14.1) (CYPVIB6) 72 2e-12
CPC7_RAT (P05179) Cytochrome P450 2C7 (EC 1.14.14.1) (CYPIIC7) (... 72 3e-12
CP34_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine... 71 4e-12
C761_SOLME (P37121) Cytochrome P450 76A1 (EC 1.14.-.-) (CYPLXXVI... 71 4e-12
CP33_HUMAN (P05184) Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3... 70 8e-12
C6AL_DROME (Q9V774) Probable cytochrome P450 6a21 (EC 1.14.-.-) ... 70 8e-12
T13H_TAXCU (Q8W4T9) Taxane 13-alpha-hydroxylase (EC 1.14.13.77) ... 70 1e-11
CPC3_RABIT (P00182) Cytochrome P450 2C3 (EC 1.14.14.1) (CYPIIC3)... 70 1e-11
CP3D_MOUSE (Q64464) Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) 70 1e-11
>C90C_ARATH (Q9M066) Cytochrome P450 90C1 (EC 1.14.-.-)
(ROTUNDIFOLIA3)
Length = 524
Score = 248 bits (634), Expect = 1e-65
Identities = 134/247 (54%), Positives = 170/247 (68%), Gaps = 21/247 (8%)
Query: 56 GYSSCPVTFMEKRKSILYKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVV 115
G P+ F R LYKSLKAKER++KMV ++VEER + + NDVV
Sbjct: 244 GLICIPIKFPGTR---LYKSLKAKERLIKMVKKVVEERQVAMTTTSP--------ANDVV 292
Query: 116 DALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKL 175
D LLRD G+ + S S + +S I+E MIPGEET+PTAMTLA+KFL+D P+AL+KL
Sbjct: 293 DVLLRDGGDSEKQSQPS----DFVSGKIVEMMIPGEETMPTAMTLAVKFLSDNPVALAKL 348
Query: 176 MEENMELKKQKTNCPDGYTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYL 235
+EENME+K++K + Y WTDYMSL FTQNVI+ETLRMANI+NG+WRKA+KDVEIKGYL
Sbjct: 349 VEENMEMKRRKLELGEEYKWTDYMSLSFTQNVINETLRMANIINGVWRKALKDVEIKGYL 408
Query: 236 IPKDWGVMASLTSVHMDSKNYENPYKFDPWRWEII--YLHEAIIYTMF----YACRKLEL 289
IPK W V+AS SVHMD Y+NPY+FDPWRW+ I + +I +T F C LEL
Sbjct: 409 IPKGWCVLASFISVHMDEDIYDNPYQFDPWRWDRINGSANSSICFTPFGGGQRLCPGLEL 468
Query: 290 CLVTIAL 296
+ I++
Sbjct: 469 SKLEISI 475
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/79 (43%), Positives = 52/79 (65%), Gaps = 1/79 (1%)
Query: 23 KEKNNIKLRNGIKIPKGNSGWPLLGETLDFIASGYSSCPVTFMEKRKSILYKSLKAKERM 82
+E++N + + G+ IP G+ GWP++GETL+FIA GYSS PVTFM+KRKS+ K K
Sbjct: 57 EEEDNEEKKKGM-IPNGSLGWPVIGETLNFIACGYSSRPVTFMDKRKSLYGKVFKTNIIG 115
Query: 83 MKMVGRIVEERMKLIMDNN 101
++ E K+++ N+
Sbjct: 116 TPIIISTDAEVNKVVLQNH 134
>C901_ARATH (Q42569) Cytochrome P450 90A1 (EC 1.14.-.-)
Length = 472
Score = 141 bits (355), Expect = 3e-33
Identities = 72/183 (39%), Positives = 115/183 (62%), Gaps = 14/183 (7%)
Query: 88 RIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFM 147
++ E ++M E++E D++ ALL ++ E I ++ +
Sbjct: 226 KVAEALTVVVMKRREEEEEGAERKKDMLAALL---------AADDGFSDEEIVDFLVALL 276
Query: 148 IPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDGYT--WTDYMSLPFTQ 205
+ G ET T MTLA+KFLT+ PLAL++L EE+ +++ K+ D Y+ W+DY S+PFTQ
Sbjct: 277 VAGYETTSTIMTLAVKFLTETPLALAQLKEEHEKIRAMKS---DSYSLEWSDYKSMPFTQ 333
Query: 206 NVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDPW 265
V++ETLR+ANI+ G++R+A+ DVEIKGY IPK W V +S +VH+D ++++ F+PW
Sbjct: 334 CVVNETLRVANIIGGVFRRAMTDVEIKGYKIPKGWKVFSSFRAVHLDPNHFKDARTFNPW 393
Query: 266 RWE 268
RW+
Sbjct: 394 RWQ 396
>CP85_LYCES (Q43147) Cytochrome P450 85 (EC 1.14.-.-) (Dwarf
protein)
Length = 464
Score = 111 bits (278), Expect = 2e-24
Identities = 60/195 (30%), Positives = 111/195 (56%), Gaps = 18/195 (9%)
Query: 73 YKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSS 132
++ +A++ ++ ++ ++EER + +D++ L+ + E ++ +
Sbjct: 217 HRGFQARKIIVNLLRTLIEERRA-----------SKEIQHDMLGYLMNE--EATRFKLTD 263
Query: 133 NLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG 192
+ M+++I I + G ET+ T +A+K+L D+P L +L +E+M ++++K D
Sbjct: 264 DEMIDLI----ITILYSGYETVSTTSMMAVKYLHDHPKVLEELRKEHMAIREKKKP-EDP 318
Query: 193 YTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
+ DY S+ FT+ VI ET R+A IVNG+ RK +D+EI GY+IPK W + ++ D
Sbjct: 319 IDYNDYRSMRFTRAVILETSRLATIVNGVLRKTTQDMEINGYIIPKGWRIYVYTRELNYD 378
Query: 253 SKNYENPYKFDPWRW 267
+ Y +PY F+PWRW
Sbjct: 379 PRLYPDPYSFNPWRW 393
Score = 32.3 bits (72), Expect = 1.9
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 26 NNIKLRNGIKIPKGNSGWPLLGETLDFIASGYS 58
N +K N +P G GWPL GET +F+ G S
Sbjct: 25 NQVKY-NQKNLPPGTMGWPLFGETTEFLKLGPS 56
>KAO1_HORVU (Q9AXH9) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)
(gpr5)
Length = 499
Score = 90.5 bits (223), Expect = 6e-18
Identities = 57/196 (29%), Positives = 93/196 (47%), Gaps = 9/196 (4%)
Query: 73 YKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSS 132
+K+++A+ R++ + R+++ER + D++D L+ + E
Sbjct: 238 HKAIRARRRLVAALQRVLDERRA----RGGKTAAGAAAPVDMMDRLIAVEDE-----GGR 288
Query: 133 NLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG 192
L + I ++ ++ G E+ A FL + P L+K E + + G
Sbjct: 289 RLQDDEIIDVLVMYLNAGHESSGHITMWATVFLQENPEILAKAKAEQEAIMRSIPPGQKG 348
Query: 193 YTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
T D+ + + V+ ETLR NI +R+A +DV + GYLIPK W V SVHMD
Sbjct: 349 LTLRDFRKMAYLSQVVDETLRFVNISFVSFRQATRDVFVNGYLIPKGWKVQLWYRSVHMD 408
Query: 253 SKNYENPYKFDPWRWE 268
+ Y +P KFDP RWE
Sbjct: 409 PQVYPDPKKFDPSRWE 424
>C881_MAIZE (Q43246) Cytochrome P450 88A1 (EC 1.14.-.-) (Dwarf3
protein)
Length = 519
Score = 87.8 bits (216), Expect = 4e-17
Identities = 58/194 (29%), Positives = 96/194 (48%), Gaps = 11/194 (5%)
Query: 75 SLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSSNL 134
+L+A+ R++ ++ +++ER A+ GV D++D L+ +Q +L
Sbjct: 265 ALRARRRLVAVLQGVLDERRAA----RAKGVSGGGV--DMMDRLIE-----AQDERGRHL 313
Query: 135 MVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDGYT 194
+ I ++ ++ G E+ A FL + P ++ E + + + G T
Sbjct: 314 DDDEIIDVLVMYLNAGHESSGHITMWATVFLQENPDMFARAKAEQEAIMRSIPSSQRGLT 373
Query: 195 WTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSK 254
D+ + + VI ETLR+ NI +R+A +DV + GYLIPK W V SVHMD +
Sbjct: 374 LRDFRKMEYLSQVIDETLRLVNISFVSFRQATRDVFVNGYLIPKGWKVQLWYRSVHMDPQ 433
Query: 255 NYENPYKFDPWRWE 268
Y +P KFDP RWE
Sbjct: 434 VYPDPTKFDPSRWE 447
>KAO1_ARATH (O23051) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)
(AtKAO1) (Cytochrome P450 88A3)
Length = 490
Score = 86.3 bits (212), Expect = 1e-16
Identities = 59/211 (27%), Positives = 98/211 (45%), Gaps = 11/211 (5%)
Query: 73 YKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSS 132
+++LKA++ ++ IV ER N + D++D LL K E
Sbjct: 235 HRALKARKTLVAAFQSIVTER------RNQRKQNILSNKKDMLDNLLNVKDE-----DGK 283
Query: 133 NLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG 192
L E I ++ ++ G E+ + A FL ++P L + E + K + G
Sbjct: 284 TLDDEEIIDVLLMYLNAGHESSGHTIMWATVFLQEHPEVLQRAKAEQEMILKSRPEGQKG 343
Query: 193 YTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
+ + + F V+ ETLR+ +R+A DVE+ GYLIPK W V+ VH+D
Sbjct: 344 LSLKETRKMEFLSQVVDETLRVITFSLTAFREAKTDVEMNGYLIPKGWKVLTWFRDVHID 403
Query: 253 SKNYENPYKFDPWRWEIIYLHEAIIYTMFYA 283
+ + +P KFDP RW+ ++ +A + F A
Sbjct: 404 PEVFPDPRKFDPARWDNGFVPKAGAFLPFGA 434
>T10H_TAXCU (Q9AXM6) Taxane 10-beta-hydroxylase (EC 1.14.13.76)
(5-alpha-taxadienol-10-beta-hydroxylase) (Cytochrome
P450 725A1)
Length = 497
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/223 (26%), Positives = 102/223 (44%), Gaps = 15/223 (6%)
Query: 46 LGETLDFIASGYSSCPVTFMEKRKSILYKSLKAKERMMKMVGRIVEERMKLIMDNNAEDD 105
L L+ I G S P+ F R K L+A+ ++ +++ +++ R + + A DD
Sbjct: 215 LHHLLETILVGSLSVPLDFPGTRYR---KGLQARLKLDEILSSLIKRRRRDLRSGIASDD 271
Query: 106 EKVGVVNDVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGEETLPTAMTLALKFL 165
+ D++ LL + E S + ++ N +T M L K L
Sbjct: 272 Q------DLLSVLLTFRDEKGNSLTDQGIL-----DNFSAMFHASYDTTVAPMALIFKLL 320
Query: 166 TDYPLALSKLMEENMELKKQKTNCPDGYTWTDYMSLPFTQNVISETLRMANIVNGIWRKA 225
P K+ +E +E+ K + +W D S+ +T + E+LRM V GI+RKA
Sbjct: 321 YSNPEYHEKVFQEQLEIIGNKKEGEE-ISWKDLKSMKYTWQAVQESLRMYPPVFGIFRKA 379
Query: 226 VKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDPWRWE 268
+ D+ GY IPK W V+ S + H+ + + P +F P R+E
Sbjct: 380 ITDIHYDGYTIPKGWRVLCSPYTTHLREEYFPEPEEFRPSRFE 422
Score = 35.0 bits (79), Expect = 0.29
Identities = 14/38 (36%), Positives = 23/38 (59%)
Query: 31 RNGIKIPKGNSGWPLLGETLDFIASGYSSCPVTFMEKR 68
R+ +K+P G G+PL+GET+ + + S P F + R
Sbjct: 45 RSSVKLPPGKLGFPLIGETIQLLRTLRSETPQKFFDDR 82
>KAO2_ARATH (Q9C5Y2) Ent-kaurenoic acid oxidase 2 (EC 1.14.13.79)
(AtKAO2) (Cytochrome P450 88A4)
Length = 489
Score = 78.6 bits (192), Expect = 2e-14
Identities = 54/196 (27%), Positives = 95/196 (47%), Gaps = 12/196 (6%)
Query: 73 YKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSS 132
+++LKA+++++ IV R N + + + D++D L+ K E +
Sbjct: 234 HRALKARKKLVAAFQSIVTNRRNQRKQNISSNRK------DMLDNLIDVKDE-----NGR 282
Query: 133 NLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG 192
L E I ++ ++ G E+ A + ++P+ L K EE + K++
Sbjct: 283 VLDDEEIIDLLLMYLNAGHESSGHLTMWATILMQEHPMILQKAKEEQERIVKKRAP-GQK 341
Query: 193 YTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
T + + + VI ETLR+ +R+A DV++ GY+IPK W V+ +VH+D
Sbjct: 342 LTLKETREMVYLSQVIDETLRVITFSLTAFREAKSDVQMDGYIIPKGWKVLTWFRNVHLD 401
Query: 253 SKNYENPYKFDPWRWE 268
+ Y +P KFDP RWE
Sbjct: 402 PEIYPDPKKFDPSRWE 417
>CPCD_RAT (P20814) Cytochrome P450 2C13, male-specific (EC
1.14.14.1) (CYPIIC13) (P450-G) (UT-5)
Length = 490
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/172 (28%), Positives = 85/172 (48%), Gaps = 10/172 (5%)
Query: 97 IMDNNAEDDEKVGVVN--DVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGEETL 154
+++ E +E + V N D +D L ++ + ++ N +E ++ + + G ET+
Sbjct: 244 LLEKIKEHEESLDVSNPRDFIDYFLIERNQ-ENANQWMNYTLEHLAIMVTDLFFAGIETV 302
Query: 155 PTAMTLALKFLTDYPLALSKLMEE-NMELKKQKTNCPDGYTWTDYMSLPFTQNVISETLR 213
+ M AL L YP +K+ EE + + + ++ C D +P+T ++ E R
Sbjct: 303 SSTMRFALLLLMKYPHVTAKVQEEIDHVIGRHRSPCMQ-----DRSHMPYTNAMVHEVQR 357
Query: 214 MANI-VNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDP 264
+I NG+ + D + + Y IPK V+ SLTSV DSK + NP FDP
Sbjct: 358 YIDIGPNGLLHEVTCDTKFRNYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDP 409
>CPCU_RABIT (Q29510) Cytochrome P450 2C30 (EC 1.14.14.1) (CYPIIC30)
Length = 489
Score = 72.8 bits (177), Expect = 1e-12
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 10/181 (5%)
Query: 88 RIVEERMKLIMDNNAEDDEKVGVVN--DVVDALLRDKGELSQSSSSSNLMVEMISQNIIE 145
++ ++MK + E E + N D +D LL K E + + S + + I +
Sbjct: 234 KVFNDQMKFFSEKIREHQESLDHNNPRDFIDYLLI-KMEKEKHNKQSQFTMHHLLVTIWD 292
Query: 146 FMIPGEETLPTAMTLALKFLTDYPLALSKLMEE-NMELKKQKTNCPDGYTWTDYMSLPFT 204
G +T + M L L +P +K+ EE + + ++ C D +P+T
Sbjct: 293 VFDAGSQTTSSTMQFGLLLLMKHPEIAAKVQEEIERVIGRDRSPCMQ-----DRSCMPYT 347
Query: 205 QNVISETLRMANIV-NGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFD 263
VI E R ++V N + +D++ +GYLIPK ++ SLTSV D K + NP KFD
Sbjct: 348 DAVIHEIQRYIDMVPNNVPHAVTQDIQFRGYLIPKGTHILPSLTSVLYDEKEFPNPEKFD 407
Query: 264 P 264
P
Sbjct: 408 P 408
>CPZ4_MOUSE (P56656) Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39)
Length = 490
Score = 72.4 bits (176), Expect = 2e-12
Identities = 54/172 (31%), Positives = 82/172 (47%), Gaps = 10/172 (5%)
Query: 97 IMDNNAEDDEKVGVVN--DVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGEETL 154
+++ E E + V N D +D L K + + + +E ++ I G ET
Sbjct: 244 LLEKIKEHQESLDVTNPRDFIDYYLI-KQKQANHIQQAEFSLENLACTINNLFAAGTETT 302
Query: 155 PTAMTLALKFLTDYPLALSKLMEE-NMELKKQKTNCPDGYTWTDYMSLPFTQNVISETLR 213
T + AL L YP +K+ EE + + + ++ C D +P+T +I E R
Sbjct: 303 STTLRYALLLLMKYPDVTAKVQEEIDHVIGRHRSPCMQ-----DRNHMPYTDAMIHEVQR 357
Query: 214 MANIV-NGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDP 264
N+V N I R D++ + YLIPK V+ SLTSV DSK + NP FDP
Sbjct: 358 FINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPNPELFDP 409
>C6B6_HELAM (Q95031) Cytochrome P450 6B6 (EC 1.14.14.1) (CYPVIB6)
Length = 504
Score = 72.0 bits (175), Expect = 2e-12
Identities = 63/190 (33%), Positives = 96/190 (50%), Gaps = 15/190 (7%)
Query: 90 VEERMKLIMDNN-AEDDEKVGVVNDVVDALL--RDKGELSQS---SSSSNLMV--EMISQ 141
V+ K ++DN A+ + K ND +D +L R GE++ + SS+S+L + E+I
Sbjct: 238 VKNFFKSLVDNIVAQRNGKPSGRNDFMDLILELRQLGEVTSNKYGSSASSLEITDEVICA 297
Query: 142 NIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG-YTWTDYMS 200
F I G ET T M + L P +KL+ E E+ K DG T+
Sbjct: 298 QAFVFYIAGYETSATTMAYMIYQLALSPDIQNKLIAEVDEVLKAN----DGKVTYDTVKE 353
Query: 201 LPFTQNVISETLRMANIVNGIWRKAVKDVEIKG--YLIPKDWGVMASLTSVHMDSKNYEN 258
+ + ETLRM +IV + RKA +D +I G +I KD V+ S +H D K Y+N
Sbjct: 354 MKYMNKAFDETLRMYSIVEPLQRKATRDYKIPGTDVVIEKDTIVLISPRGIHYDPKYYDN 413
Query: 259 PYKFDPWRWE 268
P +F+P R++
Sbjct: 414 PKQFNPDRFD 423
>CPC7_RAT (P05179) Cytochrome P450 2C7 (EC 1.14.14.1) (CYPIIC7)
(P450F) (PTF1)
Length = 490
Score = 71.6 bits (174), Expect = 3e-12
Identities = 55/166 (33%), Positives = 82/166 (49%), Gaps = 10/166 (6%)
Query: 103 EDDEKVGVVN--DVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGEETLPTAMTL 160
E E + V N D VD L K + + + S E ++ +I++ + G ET+ T +
Sbjct: 250 EHQESLDVTNPRDFVDYYLI-KQKQANNIEQSEYSHENLTCSIMDLIGAGTETMSTTLRY 308
Query: 161 ALKFLTDYPLALSKLMEE-NMELKKQKTNCPDGYTWTDYMSLPFTQNVISETLRMANIVN 219
AL L YP +K+ EE + + + ++ C D +P+T +I E R N V
Sbjct: 309 ALLLLMKYPHVTAKVQEEIDRVIGRHRSPCMQ-----DRKHMPYTDAMIHEVQRFINFVP 363
Query: 220 GIWRKAVK-DVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDP 264
AV D++ + YLIPK V+ SLTSV DSK + NP FDP
Sbjct: 364 TNLPHAVTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFDP 409
>CP34_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine
3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (NF-25)
(P450-PCN1)
Length = 502
Score = 71.2 bits (173), Expect = 4e-12
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 7/182 (3%)
Query: 86 VGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSSNLMVEMISQNIIE 145
V + + +K + ++ ED +K V D + ++ + S + +E+++Q+II
Sbjct: 244 VTNFLRKSVKRMKESRLEDTQKHRV--DFLQLMIDSQNSKETESHKALSDLELVAQSII- 300
Query: 146 FMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDGYTWTDYMSLPFTQ 205
F+ G ET + ++ + L +P KL EE + K T+ + + +
Sbjct: 301 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP----TYDTVLQMEYLD 356
Query: 206 NVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDPW 265
V++ETLR+ I + R KDVEI G IPK W VM ++H D K + P KF P
Sbjct: 357 MVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPE 416
Query: 266 RW 267
R+
Sbjct: 417 RF 418
>C761_SOLME (P37121) Cytochrome P450 76A1 (EC 1.14.-.-) (CYPLXXVIA1)
(P-450EG8) (Fragment)
Length = 467
Score = 71.2 bits (173), Expect = 4e-12
Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 22/195 (11%)
Query: 77 KAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSSNLMV 136
K KE K + +EER K EK + D++D L+ +G S L
Sbjct: 210 KGKEITKKFIEERIEERKK---------GEKNRSIKDLLDVLIDFEG--SGKDEPDKLSE 258
Query: 137 EMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMEL---KKQKTNCPDGY 193
+ I+ I+E + G ET +++ AL L +P A++K+ E +++ K+ C
Sbjct: 259 DEITVIILEMFLAGTETTSSSVEWALTELLRHPQAMAKVKLEILQVIGPNKKFEEC---- 314
Query: 194 TWTDYMSLPFTQNVISETLRM-ANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
D SLP+ Q V+ E LR+ + I RKA++D + GY IPK V+ + ++ D
Sbjct: 315 ---DIDSLPYMQAVLKEQLRLHPPLPLLIPRKAIQDTKFMGYDIPKGTQVLVNAWAIGRD 371
Query: 253 SKNYENPYKFDPWRW 267
+ ++NP++F P R+
Sbjct: 372 PEYWDNPFEFKPERF 386
>CP33_HUMAN (P05184) Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3)
(HLp)
Length = 503
Score = 70.1 bits (170), Expect = 8e-12
Identities = 53/184 (28%), Positives = 89/184 (47%), Gaps = 10/184 (5%)
Query: 86 VGRIVEERMKLIMDNNAEDDEK--VGVVNDVVDALLRDKGELSQSSSSSNLMVEMISQNI 143
V + + +K + ++ ED +K V + ++D+ K S + S +E+++Q+I
Sbjct: 244 VTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSD---LELVAQSI 300
Query: 144 IEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDGYTWTDYMSLPF 203
I F+ G ET + ++ + L +P KL EE + K T+ + + +
Sbjct: 301 I-FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP----TYDTVLQMEY 355
Query: 204 TQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFD 263
V++ETLR+ I + R KDVEI G IPK W VM ++H D K + P KF
Sbjct: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFL 415
Query: 264 PWRW 267
P R+
Sbjct: 416 PERF 419
>C6AL_DROME (Q9V774) Probable cytochrome P450 6a21 (EC 1.14.-.-)
(CYPVIA21)
Length = 504
Score = 70.1 bits (170), Expect = 8e-12
Identities = 56/196 (28%), Positives = 93/196 (46%), Gaps = 14/196 (7%)
Query: 78 AKERMMKMVGRIVEER-MKLIMDNNAEDDEKVGVVNDVVDALLRDKGE---LSQSSSSSN 133
A+ MKM +E M+++ + A ++ ND +D L+ K + +SQS S N
Sbjct: 233 ARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN 292
Query: 134 LMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKT--NCPD 191
L +E I+ F G ET T M AL Y LA ++ ++ + + Q+ C
Sbjct: 293 LTIEEIAAQAFVFFAAGFETSSTTMGFAL-----YELAQNQDIQNRVRKECQEVIEKCNG 347
Query: 192 GYTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKG---YLIPKDWGVMASLTS 248
+ L + V+SETLR+ ++ + R+ ++D E+ G Y+I K V+ +
Sbjct: 348 ELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGA 407
Query: 249 VHMDSKNYENPYKFDP 264
+H D K Y NP F+P
Sbjct: 408 MHRDEKLYANPNTFNP 423
>T13H_TAXCU (Q8W4T9) Taxane 13-alpha-hydroxylase (EC 1.14.13.77)
(Cytochrome P450 725A2)
Length = 485
Score = 69.7 bits (169), Expect = 1e-11
Identities = 42/196 (21%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 73 YKSLKAKERMMKMVGRIVEERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSS 132
+K+++A+ + ++ ++E+R + A +++ D++ LL E S +
Sbjct: 227 HKAIQARATLADIMTHLIEKRRNELRAGTASENQ------DLLSVLLTFTDERGNSLADK 280
Query: 133 NLMVEMISQNIIEFMIPGEETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDG 192
++ N + ++ + +T+ +K L +P + K+ +E + K +
Sbjct: 281 EIL-----DNFSMLLHGSYDSTNSPLTMLIKVLASHPESYEKVAQEQFGILSTKMEGEE- 334
Query: 193 YTWTDYMSLPFTQNVISETLRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMD 252
W D + ++ V+ ETLRM + G +RKA+ D+ GY IPK W ++ + S
Sbjct: 335 IAWKDLKEMKYSWQVVQETLRMYPPIFGTFRKAITDIHYNGYTIPKGWKLLWTTYSTQTK 394
Query: 253 SKNYENPYKFDPWRWE 268
+ +++ +F P R+E
Sbjct: 395 EEYFKDADQFKPSRFE 410
Score = 46.2 bits (108), Expect = 1e-04
Identities = 23/64 (35%), Positives = 41/64 (63%), Gaps = 5/64 (7%)
Query: 7 VYVSIIVLLMSLWFVKKEKNNIKLRNGIKIPKGNSGWPLLGETLDFIASGYSSCPVTFME 66
++V++ V+ + F + ++++ +K+P GN G+PL+GETL F+ S SS P F+E
Sbjct: 14 LFVTLAVMAGIILFFRSKRHS-----SVKLPPGNLGFPLVGETLQFVRSLGSSTPQQFIE 68
Query: 67 KRKS 70
+R S
Sbjct: 69 ERMS 72
>CPC3_RABIT (P00182) Cytochrome P450 2C3 (EC 1.14.14.1) (CYPIIC3)
(P450 PBC3) (P450 form 3B)
Length = 489
Score = 69.7 bits (169), Expect = 1e-11
Identities = 53/179 (29%), Positives = 84/179 (46%), Gaps = 10/179 (5%)
Query: 90 VEERMKLIMDNNAEDDEKVGVVN--DVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFM 147
++ ++K I++ E E + N D VD L K E + S ++ + I +
Sbjct: 236 IDGQIKFILEKVQEHQESLDSNNPRDFVDHFLI-KMEKEKHKKQSEFTMDNLITTIWDVF 294
Query: 148 IPGEETLPTAMTLALKFLTDYPLALSKLMEE-NMELKKQKTNCPDGYTWTDYMSLPFTQN 206
G +T + AL L +P +K+ EE + + ++ C D +P+T
Sbjct: 295 SAGTDTTSNTLKFALLLLLKHPEITAKVQEEIEHVIGRHRSPCMQ-----DRTRMPYTDA 349
Query: 207 VISETLRMANIVNGIWRKAV-KDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDP 264
V+ E R ++V AV +D+E GYLIPK ++ SLTSV D K + NP KFDP
Sbjct: 350 VMHEIQRYVDLVPTSLPHAVTQDIEFNGYLIPKGTDIIPSLTSVLYDDKEFPNPEKFDP 408
>CP3D_MOUSE (Q64464) Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13)
Length = 503
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/176 (29%), Positives = 86/176 (48%), Gaps = 10/176 (5%)
Query: 92 ERMKLIMDNNAEDDEKVGVVNDVVDALLRDKGELSQSSSSSNLMVEMISQNIIEFMIPGE 151
ERMK +N ++ EK V D + ++ + ++ S + VE+++Q++I F+ G
Sbjct: 254 ERMK---ENRMKEKEKQRV--DFLQLMINSQNYKTKESHKALSDVEIVAQSVI-FIFAGY 307
Query: 152 ETLPTAMTLALKFLTDYPLALSKLMEENMELKKQKTNCPDGYTWTDYMSLPFTQNVISET 211
ET +A++ AL L +P KL +E K T+ + + + V++ET
Sbjct: 308 ETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPA----TYDTLLQMEYLDMVVNET 363
Query: 212 LRMANIVNGIWRKAVKDVEIKGYLIPKDWGVMASLTSVHMDSKNYENPYKFDPWRW 267
LR+ I + R DVEI G IPK VM ++H D K + P +F P R+
Sbjct: 364 LRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERF 419
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.328 0.142 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,883,932
Number of Sequences: 164201
Number of extensions: 1484902
Number of successful extensions: 5808
Number of sequences better than 10.0: 576
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 5165
Number of HSP's gapped (non-prelim): 679
length of query: 355
length of database: 59,974,054
effective HSP length: 111
effective length of query: 244
effective length of database: 41,747,743
effective search space: 10186449292
effective search space used: 10186449292
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Medicago: description of AC136451.2