BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC135801.5 - phase: 0
(736 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
NCPR_CATRO (Q05001) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 1074 0.0
NCPR_PHAAU (P37116) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 915 0.0
NCPR_PIG (P04175) NADPH--cytochrome P450 reductase (EC 1.6.2.4) ... 436 e-121
NCPR_RABIT (P00389) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 435 e-121
NCPR_RAT (P00388) NADPH--cytochrome P450 reductase (EC 1.6.2.4) ... 432 e-120
NCPR_MOUSE (P37040) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 432 e-120
NCPR_HUMAN (P16435) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 431 e-120
NCPR_CAVPO (P37039) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 427 e-119
NCPR_DROME (Q27597) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 427 e-119
NCPR_MUSDO (Q07994) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 424 e-118
NCPR_SALTR (P19618) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 380 e-105
NCPR_ASPNG (Q00141) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 333 1e-90
NCPR_CANMA (P50126) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 304 5e-82
NCPR_YEAST (P16603) NADPH--cytochrome P450 reductase (EC 1.6.2.4... 277 8e-74
NOS1_RABIT (O19132) Nitric-oxide synthase, brain (EC 1.14.13.39)... 259 2e-68
NOS3_HUMAN (P29474) Nitric-oxide synthase, endothelial (EC 1.14.... 254 4e-67
NOS3_MOUSE (P70313) Nitric-oxide synthase, endothelial (EC 1.14.... 254 7e-67
NOS1_RAT (P29476) Nitric-oxide synthase, brain (EC 1.14.13.39) (... 253 1e-66
NOS3_BOVIN (P29473) Nitric-oxide synthase, endothelial (EC 1.14.... 249 1e-65
NOS3_PIG (Q28969) Nitric-oxide synthase, endothelial (EC 1.14.13... 247 7e-65
>NCPR_CATRO (Q05001) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 714
Score = 1074 bits (2778), Expect = 0.0
Identities = 534/749 (71%), Positives = 618/749 (82%), Gaps = 51/749 (6%)
Query: 3 DSSSMKFSPLDLMSALIKG-KIDPSNGT------VPA--SLILENREFVMILTTSIAVLI 53
DSSS K SP +LMSA++KG K+D SN + PA +++LEN+E VMILTTS+AVLI
Sbjct: 2 DSSSEKLSPFELMSAILKGAKLDGSNSSDSGVAVSPAVMAMLLENKELVMILTTSVAVLI 61
Query: 54 GCVVVLIWRRSNSQKPKPIEVPKRVIEKL---PELEIDDGTKKVTVFFGTQTGTAEGFAK 110
GCVVVLIWRRS+ K +E PK ++ K PE EID+G KK T+FFGTQTGTAEGFAK
Sbjct: 62 GCVVVLIWRRSSGSGKKVVEPPKLIVPKSVVEPE-EIDEGKKKFTIFFGTQTGTAEGFAK 120
Query: 111 AIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALFFLATYGDGEPTDNAARFY 170
A+AEEAKARYEKA KV+D+DDYAADD+EYEEK +KET+A F LATYGDGEPTDNAARFY
Sbjct: 121 ALAEEAKARYEKAVIKVIDIDDYAADDEEYEEKFRKETLAFFILATYGDGEPTDNAARFY 180
Query: 171 KWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAF 230
KWF E D KNLQYGVFGLGNRQYEHFNK+
Sbjct: 181 KWFVEGNDRGDWLKNLQYGVFGLGNRQYEHFNKI-------------------------- 214
Query: 231 SDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDED 290
AK+VD+K+ E+GG R+VP+ LGDDDQCIEDDF AW+E +WP LD LLRDED
Sbjct: 215 ---------AKVVDEKVAEQGGKRIVPLVLGDDDQCIEDDFAAWRENVWPELDNLLRDED 265
Query: 291 DATVATPYTASVLEYRVVIRDQLDATVDEKK-QLNG--NGHAVVDAHHPVRANVAVRKEL 347
D TV+T YTA++ EYRVV D+ D+ + E NG NG+ V DA HP R+NVAVRKEL
Sbjct: 266 DTTVSTTYTAAIPEYRVVFPDKSDSLISEANGHANGYANGNTVYDAQHPCRSNVAVRKEL 325
Query: 348 HTPASDRSCTHLEFDISGTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTD 407
HTPASDRSCTHL+FDI+GTG+ Y TGDHVGVYC+NLS+TVEEAER+L L P+TYFS+H D
Sbjct: 326 HTPASDRSCTHLDFDIAGTGLSYGTGDHVGVYCDNLSETVEEAERLLNLPPETYFSLHAD 385
Query: 408 DEDGKPLGGSSLPPPFPPCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLA 467
EDG PL GSSLPPPFPPCTLRTAL +YAD+L++PKKSALLALAA+ASDP+EADRL++LA
Sbjct: 386 KEDGTPLAGSSLPPPFPPCTLRTALTRYADLLNTPKKSALLALAAYASDPNEADRLKYLA 445
Query: 468 SPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPS 527
SPAGKDEYA+ ++A+QRSLLEVMAEF SAKPP+GVFFA++APRLQPR+YSISSSPR+APS
Sbjct: 446 SPAGKDEYAQSLVANQRSLLEVMAEFPSAKPPLGVFFAAIAPRLQPRFYSISSSPRMAPS 505
Query: 528 RIHVTCALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVP 587
RIHVTCALV++K P GRIH+GVCSTWMKN+ PLE+S+DCSWAPIFVRQSNF+LPAD KVP
Sbjct: 506 RIHVTCALVYEKTPGGRIHKGVCSTWMKNAIPLEESRDCSWAPIFVRQSNFKLPADPKVP 565
Query: 588 IIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGA 647
+IMIGPGTGLAPFRGFLQERLALKEEGAELG +V FFGCRNR++DYIYEDELNHF+ GA
Sbjct: 566 VIMIGPGTGLAPFRGFLQERLALKEEGAELGTAVFFFGCRNRKMDYIYEDELNHFLEIGA 625
Query: 648 LSELIVAFSREGPTKEYVQHKMIEKASDIWNMISQGAYIYVCGDAKGMAKDVHRTLHTIL 707
LSEL+VAFSREGPTK+YVQHKM EKASDIW MIS GAY+YVCGDAKGMA+DVHRTLHTI
Sbjct: 626 LSELLVAFSREGPTKQYVQHKMAEKASDIWRMISDGAYVYVCGDAKGMARDVHRTLHTIA 685
Query: 708 QEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
QEQGS+D+++ E VKNLQMTGRYLRDVW
Sbjct: 686 QEQGSMDSTQAEGFVKNLQMTGRYLRDVW 714
>NCPR_PHAAU (P37116) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 690
Score = 915 bits (2364), Expect = 0.0
Identities = 452/700 (64%), Positives = 553/700 (78%), Gaps = 42/700 (6%)
Query: 42 VMILTTSIAVLIGCVVVLIWRRSN--SQKPKPIEVPKRVI-EKLPELEIDDGTKKVTVFF 98
++I TTS AV++G ++V +W++S+ S++ KP+ VP+ ++ E+ E+++ G KVT+FF
Sbjct: 28 LLIATTSAAVVVG-LLVFLWKKSSDRSKEVKPVVVPRDLMMEEEEEVDVAAGKTKVTIFF 86
Query: 99 GTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALFFLATYG 158
GTQTGTAEGFAKA+AEE KARYEKA KVVD+DDYAADDD YEEKLKKE++ F LATYG
Sbjct: 87 GTQTGTAEGFAKALAEEIKARYEKAAVKVVDLDDYAADDDLYEEKLKKESLVFFMLATYG 146
Query: 159 DGEPTDNAARFYKWFEEFEGEEDSF-KNLQYGVFGLGNRQYEHFNKVCTQALMHSCGFLS 217
DGEP DNAARFYKWF E + E + + L YGVFGLGNRQYEHFNK+
Sbjct: 147 DGEPIDNAARFYKWFTEGKDERGIWLQKLTYGVFGLGNRQYEHFNKI------------- 193
Query: 218 FDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEE 277
K+VD++L E+G RLV VGLGDDDQ IEDDF+AWKE
Sbjct: 194 ----------------------GKVVDEELAEQGAKRLVAVGLGDDDQSIEDDFSAWKES 231
Query: 278 LWPALDQLLRDEDDA-TVATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGHAVVDAHHP 336
LW LDQLLRDEDDA TV+TPYTA++LEYRVVI D A+ + NG+ D HHP
Sbjct: 232 LWSELDQLLRDEDDANTVSTPYTAAILEYRVVIHDPTAASTYDNHSTVANGNTEFDIHHP 291
Query: 337 VRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVGVYCENLSDTVEEAERILGL 396
R NVAV+KELH P SDRSC HLEFDISGT + Y+TGDHVGVY EN ++TVEE ++LG
Sbjct: 292 CRVNVAVQKELHKPESDRSCIHLEFDISGTSITYDTGDHVGVYAENCNETVEETGKLLGQ 351
Query: 397 SPDTYFSVHTDDEDGKPLGGSSLPPPFPPCTLRTALAKYADVLSSPKKSALLALAAHASD 456
+ D +FS+HTD +DG LGGS LPP PC+LRTALA+YAD+L+ P+K+ALLALA HAS+
Sbjct: 352 NLDLFFSLHTDKDDGTSLGGSLLPPFPGPCSLRTALARYADLLNPPRKAALLALATHASE 411
Query: 457 PSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYY 516
PS+ +RL+ L+SP GKDEY++WV+ SQRSL+EVMAEF SAKPP+GVFFA++APRLQPRYY
Sbjct: 412 PSD-ERLKFLSSPQGKDEYSKWVVGSQRSLVEVMAEFPSAKPPLGVFFAAIAPRLQPRYY 470
Query: 517 SISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQS 576
SISSSPR AP R+HVTCALV+ PTGRIH+GVCSTWMKN+ P EKSQDCS APIF+R S
Sbjct: 471 SISSSPRFAPQRVHVTCALVYGPTPTGRIHKGVCSTWMKNAIPSEKSQDCSSAPIFIRPS 530
Query: 577 NFRLPADNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYE 636
NF+LP D+ +PIIM+GPGTGLAPFRGFLQER ALKE+G +LGP++LFFGCRNRQ+D+IYE
Sbjct: 531 NFKLPVDHSIPIIMVGPGTGLAPFRGFLQERYALKEDGVQLGPALLFFGCRNRQMDFIYE 590
Query: 637 DELNHFVHGGALSELIVAFSREGPTKEYVQHKMIEKASDIWNMISQGAYIYVCGDAKGMA 696
DEL FV G+LSELIVAFSREG KEYVQHKM++KA+ +W++ISQG Y+YVCGDAKGMA
Sbjct: 591 DELKSFVEQGSLSELIVAFSREGAEKEYVQHKMMDKAAHLWSLISQGGYLYVCGDAKGMA 650
Query: 697 KDVHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
+DVHRTLH+I+QEQ ++D++K E++VK LQM GRYLRDVW
Sbjct: 651 RDVHRTLHSIVQEQENVDSTKAEAIVKKLQMDGRYLRDVW 690
>NCPR_PIG (P04175) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 677
Score = 436 bits (1120), Expect = e-121
Identities = 268/739 (36%), Positives = 404/739 (54%), Gaps = 86/739 (11%)
Query: 21 GKIDPSNGTVPASLILENREFVMILTTSIAVLIGCVVVL-----IWRRSNSQKPK--PIE 73
G + GT + ++ E V + + + VL +V L I+R+ + P+ IE
Sbjct: 1 GDSNVDTGTTTSEMVAEE---VSLFSATDMVLFSLIVGLLTYWFIFRKKKDEVPEFSKIE 57
Query: 74 VPKRVIEKLPELEIDDGT-KKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDD 132
++ +E T + + VF+G+QTGTAE FA ++++A RY M
Sbjct: 58 TTTSSVKDSSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRG 108
Query: 133 YAADDDEYE----EKLKK--ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNL 186
AAD +EY+ L + +A+F +ATYG+G+PTDNA FY W +E + + +
Sbjct: 109 MAADPEEYDLSDLSSLPEIENALAVFCMATYGEGDPTDNAQDFYDWLQEADVD---LTGV 165
Query: 187 QYGVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDK 246
+Y VFGLGN+ YEHFN + K VD +
Sbjct: 166 KYAVFGLGNKTYEHFNAM-----------------------------------GKYVDKR 190
Query: 247 LLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYR 306
L + G R+ +GLGDDD +E+DF W+E+ WPA+ + E AT +S+ +Y
Sbjct: 191 LEQLGAQRIFDLGLGDDDGNLEEDFITWREQFWPAVCEHFGVE-----ATGEESSIRQYE 245
Query: 307 VVIRDQLDATV---DEKKQLNG--NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEF 361
+V+ +D V E +L N DA +P A V ++L+ ++R HLE
Sbjct: 246 LVVHTDMDTAVVYTGEMGRLKSYENQKPPFDAKNPFLAVVTTNRKLNQ-GTERHLMHLEL 304
Query: 362 DISGTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPP 421
DIS + + YE+GDHV VY N S V + ILG D S++ DE+ S+
Sbjct: 305 DISDSKIRYESGDHVAVYPANDSALVNQLGEILGTDLDIVMSLNNLDEE------SNKRH 358
Query: 422 PFP-PCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEW 478
PFP P T RTAL Y D+ + P+ + L LA +AS+PSE ++LR +AS +G K+ Y W
Sbjct: 359 PFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEQLRKMASSSGEGKELYLSW 418
Query: 479 VIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHD 538
V+ ++R +L ++ ++ S +PPI PRLQ RYYSI+SS +V P+ +H+ +V
Sbjct: 419 VVEARRHILAILQDYPSLRPPID-HLCERLPRLQARYYSIASSSKVHPNSVHICAVVVEY 477
Query: 539 KMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLA 598
+ +GR+++GV ++W++ P ++ + P+FVR+S FRLP P+IM+GPGTG+A
Sbjct: 478 ETKSGRVNKGVATSWLRAKEPAGENGRRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVA 537
Query: 599 PFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSRE 658
PF GF+QER L+E+G E+G ++L++GCR DY+Y +EL F GAL+ L VAFSRE
Sbjct: 538 PFIGFIQERAWLQEQGKEVGETLLYYGCRRSDEDYLYREELAQFHAKGALTRLSVAFSRE 597
Query: 659 GPTKEYVQHKMIEKASDIWNMISQ-GAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSK 717
P K YVQH + +W +I GA+IY+CGDA+ MA+DV T I+ EQG +++++
Sbjct: 598 QPQKVYVQHLLKRDKEHLWKLIHDGGAHIYICGDARNMARDVQNTFCDIVAEQGPMEHAQ 657
Query: 718 TESMVKNLQMTGRYLRDVW 736
VK L GRY DVW
Sbjct: 658 AVDYVKKLMTKGRYSLDVW 676
>NCPR_RABIT (P00389) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 679
Score = 435 bits (1119), Expect = e-121
Identities = 255/731 (34%), Positives = 399/731 (53%), Gaps = 80/731 (10%)
Query: 26 SNGTVPASLILENREFVMILTTSIAVLIGCVVV-LIWRRSNSQKPKPIEVPKRVIEKLPE 84
+ T+P + E F M ++++G + ++R+ + P+ ++ + E
Sbjct: 8 TGATMPEAAAQEASVFSMTDVVLFSLIVGLITYWFLFRKKKEEVPEFTKIQAPTSSSVKE 67
Query: 85 LEIDDGTKK----VTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEY 140
+ KK + VF+G+QTGTAE FA ++++A RY M AAD +EY
Sbjct: 68 SSFVEKMKKTGRNIVVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMAADPEEY 118
Query: 141 E----EKLKK--ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLG 194
+ L + +A+F +ATYG+G+PTDNA FY W +E + + ++Y VFGLG
Sbjct: 119 DLADLSSLPEINNALAVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKYAVFGLG 175
Query: 195 NRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNR 254
N+ YEHFN + K VD +L + G R
Sbjct: 176 NKTYEHFNAM-----------------------------------GKYVDQRLEQLGAQR 200
Query: 255 LVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLD 314
+ +G+GDDD +E+DF W+E+ WPA+ + E AT +S+ +Y +V+ +D
Sbjct: 201 IFELGMGDDDANLEEDFITWREQFWPAVCEHFGVE-----ATGEESSIRQYELVLHTDID 255
Query: 315 ATVDEKKQLNG-----NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVV 369
+ ++ N DA +P A V ++L+ ++R HLE DIS + +
Sbjct: 256 VAKVYQGEMGRLKSYENQKPPFDAKNPFLATVTTNRKLNQ-GTERHLMHLELDISDSKIR 314
Query: 370 YETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTL 428
YE+GDHV VY N S V + ILG D S++ DE+ S+ PFP P +
Sbjct: 315 YESGDHVAVYPANDSALVNQLGEILGADLDVVMSLNNLDEE------SNKKHPFPCPTSY 368
Query: 429 RTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEWVIASQRSL 486
RTAL Y D+ + P+ + L LA +A+DP+E ++LR +AS +G K+ Y WV+ ++R +
Sbjct: 369 RTALTYYLDITNPPRTNVLYELAQYAADPAEQEQLRKMASSSGEGKELYLSWVVEARRHI 428
Query: 487 LEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIH 546
L ++ ++ S +PPI + PRLQ RYYSI+SS +V P+ +H+ V + GR++
Sbjct: 429 LAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYETKAGRLN 487
Query: 547 QGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQE 606
+GV ++W++ P ++ + P+FVR+S FRLP P+IM+GPGTG+APF GF+QE
Sbjct: 488 KGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQE 547
Query: 607 RLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQ 666
R L+++G E+G ++L++GCR DY+Y +EL F G LS+L VAFSRE K YVQ
Sbjct: 548 RAWLRQQGKEVGETLLYYGCRRAAEDYLYREELAGFQKDGTLSQLNVAFSREQAQKVYVQ 607
Query: 667 HKMIEKASDIWNMISQ-GAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNL 725
H + +W +I + GA+IYVCGDA+ MA+DV T + I+ E G++++++ VK L
Sbjct: 608 HLLRRDKEHLWRLIHEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYVKKL 667
Query: 726 QMTGRYLRDVW 736
GRY DVW
Sbjct: 668 MTKGRYSLDVW 678
>NCPR_RAT (P00388) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 677
Score = 432 bits (1112), Expect = e-120
Identities = 261/737 (35%), Positives = 407/737 (54%), Gaps = 89/737 (12%)
Query: 24 DPSNGTVPASLILENREFVMILTTSIAVLIGCVVVL-----IWRRSNSQKPKPIEVPKRV 78
+ ++ T+P ++ E V + +T+ VL +V + I+R+ + P+ ++ +
Sbjct: 5 EDTSATMPEAVAEE----VSLFSTTDMVLFSLIVGVLTYWFIFRKKKEEIPEFSKI-QTT 59
Query: 79 IEKLPELEIDDGTKK----VTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYA 134
+ E + KK + VF+G+QTGTAE FA ++++A RY M +
Sbjct: 60 APPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMS 110
Query: 135 ADDDEYE----EKLKK--ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQY 188
AD +EY+ L + +++ +F +ATYG+G+PTDNA FY W +E + + +++
Sbjct: 111 ADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LTGVKF 167
Query: 189 GVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLL 248
VFGLGN+ YEHFN + K VD +L
Sbjct: 168 AVFGLGNKTYEHFNAM-----------------------------------GKYVDQRLE 192
Query: 249 EKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVV 308
+ G R+ +GLGDDD +E+DF W+E+ WPA+ + E AT +S+ +Y +V
Sbjct: 193 QLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVE-----ATGEESSIRQYELV 247
Query: 309 IRDQLDAT---VDEKKQLNG--NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDI 363
+ + +D E +L N DA +P A V ++L+ ++R HLE DI
Sbjct: 248 VHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQ-GTERHLMHLELDI 306
Query: 364 SGTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPF 423
S + + YE+GDHV VY N S V + ILG D S++ DE+ S+ PF
Sbjct: 307 SDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEE------SNKKHPF 360
Query: 424 P-PCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEWVI 480
P P T RTAL Y D+ + P+ + L LA +AS+PSE + L +AS +G K+ Y WV+
Sbjct: 361 PCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVV 420
Query: 481 ASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKM 540
++R +L ++ ++ S +PPI + PRLQ RYYSI+SS +V P+ +H+ V +
Sbjct: 421 EARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEA 479
Query: 541 PTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPF 600
+GR+++GV ++W++ P ++ + P+FVR+S FRLP + P+IM+GPGTG+APF
Sbjct: 480 KSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPF 539
Query: 601 RGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGP 660
GF+QER L+E+G E+G ++L++GCR DY+Y +EL F GAL++L VAFSRE
Sbjct: 540 MGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQA 599
Query: 661 TKEYVQHKMIEKASDIWNMISQ-GAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTE 719
K YVQH + +W +I + GA+IYVCGDA+ MAKDV T + I+ E G +++++
Sbjct: 600 HKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAV 659
Query: 720 SMVKNLQMTGRYLRDVW 736
VK L GRY DVW
Sbjct: 660 DYVKKLMTKGRYSLDVW 676
>NCPR_MOUSE (P37040) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 677
Score = 432 bits (1112), Expect = e-120
Identities = 262/736 (35%), Positives = 404/736 (54%), Gaps = 87/736 (11%)
Query: 24 DPSNGTVPASLILENREFVMILTTSIAVLIGCVV-VLIWRRSNSQKPKPIEVPKRVIEKL 82
+ ++ TVP ++ E V + +T+ VL +V VL + +K + I ++
Sbjct: 5 EDTSATVPEAVAEE----VSLFSTTDIVLFSLIVGVLTYWFIFKKKKEEIPEFSKIQTTA 60
Query: 83 PELEIDDGTKK-------VTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAA 135
P ++ +K + VF+G+QTGTAE FA ++++A RY M +A
Sbjct: 61 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMSA 111
Query: 136 DDDEYE----EKLKK--ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYG 189
D +EY+ L + +++ +F +ATYG+G+PTDNA FY W +E + + +++
Sbjct: 112 DPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LTGVKFA 168
Query: 190 VFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLE 249
VFGLGN+ YEHFN + K VD +L +
Sbjct: 169 VFGLGNKTYEHFNAM-----------------------------------GKYVDQRLEQ 193
Query: 250 KGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVI 309
G R+ +GLGDDD +E+DF W+E+ WPA+ + E AT +S+ +Y +V+
Sbjct: 194 LGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVE-----ATGEESSIRQYELVV 248
Query: 310 RDQLDAT---VDEKKQLNG--NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDIS 364
+ +D E +L N DA +P A V ++L+ ++R HLE DIS
Sbjct: 249 HEDMDTAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQ-GTERHLMHLELDIS 307
Query: 365 GTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP 424
+ + YE+GDHV VY N S V + ILG D S++ DE+ S+ PFP
Sbjct: 308 DSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNNLDEE------SNKKHPFP 361
Query: 425 -PCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEWVIA 481
P T RTAL Y D+ + P+ + L LA +AS+PSE + L +AS +G K+ Y WV+
Sbjct: 362 CPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVE 421
Query: 482 SQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMP 541
++R +L ++ ++ S +PPI + PRLQ RYYSI+SS +V P+ +H+ V +
Sbjct: 422 ARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAK 480
Query: 542 TGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFR 601
+GR+++GV ++W++ P ++ + P+FVR+S FRLP P+IM+GPGTG+APF
Sbjct: 481 SGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFM 540
Query: 602 GFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPT 661
GF+QER L+E+G E+G ++L++GCR DY+Y +EL F GAL++L VAFSRE
Sbjct: 541 GFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAH 600
Query: 662 KEYVQHKMIEKASDIWNMISQ-GAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTES 720
K YVQH + +W +I + GA+IYVCGDA+ MAKDV T + I+ E G +++++
Sbjct: 601 KVYVQHLLKRDKEHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVD 660
Query: 721 MVKNLQMTGRYLRDVW 736
VK L GRY DVW
Sbjct: 661 YVKKLMTKGRYSLDVW 676
>NCPR_HUMAN (P16435) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 676
Score = 431 bits (1108), Expect = e-120
Identities = 257/730 (35%), Positives = 403/730 (55%), Gaps = 80/730 (10%)
Query: 26 SNGTVPASLILENREFVMILTTSIAVLIGCVVV-LIWRRSNSQKPKPIEVPKRVIEKLPE 84
++ TV ++ E F M ++++G + ++R+ + P+ ++ + + + E
Sbjct: 7 TSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKI-QTLTSSVRE 65
Query: 85 LEIDDGTKK----VTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEY 140
+ KK + VF+G+QTGTAE FA ++++A RY M +AD +EY
Sbjct: 66 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMSADPEEY 116
Query: 141 E----EKLKK--ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLG 194
+ L + + +F +ATYG+G+PTDNA FY W +E + + +++ VFGLG
Sbjct: 117 DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLG 173
Query: 195 NRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNR 254
N+ YEHFN + K VD +L + G R
Sbjct: 174 NKTYEHFNAM-----------------------------------GKYVDKRLEQLGAQR 198
Query: 255 LVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLD 314
+ +GLGDDD +E+DF W+E+ WPA+ + E AT +S+ +Y +V+ +D
Sbjct: 199 IFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVE-----ATGEESSIRQYELVVHTDID 253
Query: 315 AT---VDEKKQLNG--NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVV 369
A + E +L N DA +P A V ++L+ ++R HLE DIS + +
Sbjct: 254 AAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQ-GTERHLMHLELDISDSKIR 312
Query: 370 YETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTL 428
YE+GDHV VY N S V + +ILG D S++ DE+ S+ PFP P +
Sbjct: 313 YESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEE------SNKKHPFPCPTSY 366
Query: 429 RTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEWVIASQRSL 486
RTAL Y D+ + P+ + L LA +AS+PSE + LR +AS +G K+ Y WV+ ++R +
Sbjct: 367 RTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHI 426
Query: 487 LEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIH 546
L ++ + S +PPI + PRLQ RYYSI+SS +V P+ +H+ +V + GRI+
Sbjct: 427 LAILQDCPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRIN 485
Query: 547 QGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQE 606
+GV + W++ P ++ + P+FVR+S FRLP P+IM+GPGTG+APF GF+QE
Sbjct: 486 KGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQE 545
Query: 607 RLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQ 666
R L+++G E+G ++L++GCR DY+Y +EL F GAL++L VAFSRE K YVQ
Sbjct: 546 RAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQ 605
Query: 667 HKMIEKASDIWNMISQGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQ 726
H + + +W +I GA+IYVCGDA+ MA+DV T + I+ E G++++++ +K L
Sbjct: 606 HLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLM 665
Query: 727 MTGRYLRDVW 736
GRY DVW
Sbjct: 666 TKGRYSLDVW 675
>NCPR_CAVPO (P37039) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 677
Score = 427 bits (1099), Expect = e-119
Identities = 248/660 (37%), Positives = 372/660 (55%), Gaps = 75/660 (11%)
Query: 92 KKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYE----EKLKK- 146
+ + VF+G+QTGTAE FA ++++A RY M AAD +EY+ L +
Sbjct: 77 RNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMAADPEEYDLADLSSLPEI 127
Query: 147 -ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVC 205
++A+F +ATYG+G+PTDNA FY W +E + + ++Y VFGLGN+ YEHFN +
Sbjct: 128 DNSLAVFCMATYGEGDPTDNAQDFYDWLQETDLD---LSGVKYAVFGLGNKTYEHFNSM- 183
Query: 206 TQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQ 265
K VD +L + G R+ +GLGDDD
Sbjct: 184 ----------------------------------GKYVDQRLEQLGAQRIFELGLGDDDG 209
Query: 266 CIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDAT---VDEKKQ 322
+E+DF W+E+ WPA+ + E AT +S+ +Y +V+ D E +
Sbjct: 210 NLEEDFITWREQFWPAVCEFFGVE-----ATGEESSIRQYELVLHADTDPAKVYTGEMGR 264
Query: 323 LNG--NGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVGVYC 380
L N DA +P A V ++L+ ++R HLE DIS + + YE+GDHV VY
Sbjct: 265 LKSYENQKPPFDAKNPFLAAVTTNRKLNQ-GTERHLMHLELDISDSKIRYESGDHVAVYP 323
Query: 381 ENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTLRTALAKYADVL 439
N S+ V + +ILG D S+ DE+ S+ PFP P T RTAL Y D+
Sbjct: 324 ANDSNLVNQLGKILGADLDVVMSLKNLDEE------SNKKHPFPCPTTYRTALTYYLDIT 377
Query: 440 SSPKKSALLALAAHASDPSEADRLRHLASPAG--KDEYAEWVIASQRSLLEVMAEFSSAK 497
+ P+ + L LA +AS+PSE ++L +AS +G K+ Y WV+ ++R +L ++ ++ S +
Sbjct: 378 NPPRTNVLYELAQYASEPSEQEQLHKMASSSGEGKELYLTWVVEARRHILAILQDYPSLR 437
Query: 498 PPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCSTWMKNS 557
PPI + PRLQ RYYSI+SS +V P+ +H+ +V + +GRI++GV ++W++
Sbjct: 438 PPID-HLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKSGRINKGVATSWLQAK 496
Query: 558 APLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAEL 617
P ++ + P+FVR+S FRLP + P+IM+GPGTG+APF GF+QER L+++G E+
Sbjct: 497 DPAGENGRRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGVAPFIGFIQERAWLQQQGKEV 556
Query: 618 GPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQHKMIEKASDIW 677
G ++L++GCR DY+Y +EL F G L++L VAFSRE K YVQH + +W
Sbjct: 557 GETLLYYGCRRSDEDYLYREELAQFHKDGTLTQLNVAFSREQAQKVYVQHLLKRDQEHLW 616
Query: 678 NMISQ-GAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
+I + GA+IYVCGDA+ MA+DV T I E G +++++ VK L GRY DVW
Sbjct: 617 KLIHEDGAHIYVCGDARNMARDVQNTFCNIAAELGGMEHTQAVDYVKKLMTKGRYSLDVW 676
>NCPR_DROME (Q27597) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 679
Score = 427 bits (1098), Expect = e-119
Identities = 257/650 (39%), Positives = 357/650 (54%), Gaps = 58/650 (8%)
Query: 92 KKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEE-KLKKETMA 150
+ + VF+G+QTGT E FA +A+E RY + K + D D +E + K ++A
Sbjct: 82 RSLVVFYGSQTGTGEEFAGRLAKEG-IRY---RLKGMVADPEECDMEELLQLKDIDNSLA 137
Query: 151 LFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVCTQALM 210
+F LATYG+G+PTDNA FY+W G+ D L Y VFGLGN+ YEH+NK
Sbjct: 138 VFCLATYGEGDPTDNAMEFYEWIT--SGDVD-LSGLNYAVFGLGNKTYEHYNK------- 187
Query: 211 HSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDD 270
VA VD +L E G NR+ +GLGDDD IEDD
Sbjct: 188 ----------------------------VAIYVDKRLEELGANRVFELGLGDDDANIEDD 219
Query: 271 FTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGHAV 330
F WK+ WPA+ E +LE V D++ + N
Sbjct: 220 FITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPP 279
Query: 331 VDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVGVYCENLSDTVEEA 390
DA +P A + V +ELH RSC H+E I G+ + Y+ GDHV ++ N VE+
Sbjct: 280 FDAKNPFLAPIKVNRELH-KGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKL 338
Query: 391 ERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTLRTALAKYADVLSSPKKSALLA 449
++ DT FS+ D D SS PFP P T RTAL Y ++ + P+ L
Sbjct: 339 GQLCNADLDTVFSLINTDTD------SSKKHPFPCPTTYRTALTHYLEITAIPRTHILKE 392
Query: 450 LAAHASDPSEADRLRHLA--SPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASV 507
LA + +D E + LR +A SP GK++Y W+ + R+++ ++ + S +PPI +
Sbjct: 393 LAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPID-HVCEL 451
Query: 508 APRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQDCS 567
PRLQPRYYSISSS ++ P+ +HVT LV K PTGRI++GV +T++KN P + S++
Sbjct: 452 LPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQP-QGSEEVK 510
Query: 568 WAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFGCR 627
P+F+R+S FRLP + PIIM+GPGTGLAPFRGF+QER L++EG +G S+L+FGCR
Sbjct: 511 -VPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCR 569
Query: 628 NRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQHKMIEKASDIWNMISQG-AYI 686
R DYIYE EL +V G L+ L AFSR+ K YVQH + + A IWN+I + +
Sbjct: 570 KRSEDYIYESELEEWVKKGTLN-LKAAFSRDQGKKVYVQHLLEQDADLIWNVIGENKGHF 628
Query: 687 YVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
Y+CGDAK MA DV L IL +G++ + +K ++ RY DVW
Sbjct: 629 YICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVW 678
>NCPR_MUSDO (Q07994) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 671
Score = 424 bits (1089), Expect = e-118
Identities = 265/712 (37%), Positives = 379/712 (53%), Gaps = 80/712 (11%)
Query: 46 TTSIAVLIGCVVVLIW--RRSNSQKPKPIE---VPKRVIEKLPELE------IDDGTKKV 94
T IA+L+ +V W RS ++ PI + + + E + + +
Sbjct: 18 TLDIALLVVLLVGATWYFMRSRKKEEAPIRSYSIQPTTVSTVSTTENSFIKKLKASGRSL 77
Query: 95 TVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDE--YEEKLKKE----T 148
VF+G+QTGTAE FA +A+E RY M AD +E EE L+ + +
Sbjct: 78 VVFYGSQTGTAEEFAGRLAKEG-LRYR--------MKGMVADPEECDMEELLQMKDIPNS 128
Query: 149 MALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVCTQA 208
+A+F LATYG+G+PTDNA FY+W GE D L Y VFGLGN+ YEH+NKV
Sbjct: 129 LAVFCLATYGEGDPTDNAMEFYEWITN--GEVD-LTGLNYAVFGLGNKTYEHYNKVA--- 182
Query: 209 LMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIE 268
IY VD +L E G R+ +GLGDDD IE
Sbjct: 183 ------------------------IY--------VDKRLEELGATRVFELGLGDDDANIE 210
Query: 269 DDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGH 328
DDF WK+ WP++ E +LE V D++ + N
Sbjct: 211 DDFITWKDRFWPSVCDFFGIEGSGEEVLMRQFRLLEQPDVQPDRIYTGEIARLHSMQNQR 270
Query: 329 AVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVGVYCENLSDTVE 388
DA +P A+V V +ELH RSC H+E DI G+ + Y+ GDH+ +Y N VE
Sbjct: 271 PPFDAKNPFLASVIVNRELHK-GGGRSCMHIELDIDGSKMRYDAGDHIAMYPINDKILVE 329
Query: 389 EAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTLRTALAKYADVLSSPKKSAL 447
+ ++ + DT FS+ D D SS PFP P T RTAL Y ++ + P+ L
Sbjct: 330 KLGKLCDANLDTVFSLINTDTD------SSKKHPFPCPTTYRTALTHYLEITAIPRTHIL 383
Query: 448 LALAAHASDPSEADRLRHLAS--PAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFA 505
LA + SD + + LR++AS P GK++Y W+ S R+++ ++ + S +PPI
Sbjct: 384 KELAEYCSDEKDKEFLRNMASITPEGKEKYQNWIQNSSRNIVHILEDIKSCRPPID-HIC 442
Query: 506 SVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQD 565
+ PRLQPRYYSISSS ++ P+ +H+T LV + PTGR+++GV +++MK P S
Sbjct: 443 ELLPRLQPRYYSISSSSKLYPTNVHITAVLVQYETPTGRVNKGVATSYMKEKNP---SVG 499
Query: 566 CSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFG 625
P+F+R+S FRLP +++PIIM+GPGTGLAPFRGF+QER L++ G +G ++L+FG
Sbjct: 500 EVKVPVFIRKSQFRLPTKSEIPIIMVGPGTGLAPFRGFIQERQFLRDGGKVVGDTILYFG 559
Query: 626 CRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQHKMIEKASDIWNMI-SQGA 684
CR + D+IY +EL +V G L+ L AFSR+ K YV H + + A IW +I Q
Sbjct: 560 CRKKDEDFIYREELEQYVQNGTLT-LKTAFSRDQQEKIYVTHLIEQDADLIWKVIGEQKG 618
Query: 685 YIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
+ Y+CGDAK MA DV L IL +G+++ S +K ++ RY DVW
Sbjct: 619 HFYICGDAKNMAVDVRNILVKILSTKGNMNESDAVQYIKKMEAQKRYSADVW 670
>NCPR_SALTR (P19618) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R) (Fragments)
Length = 601
Score = 380 bits (975), Expect = e-105
Identities = 238/684 (34%), Positives = 360/684 (51%), Gaps = 102/684 (14%)
Query: 68 KPKPIEVPKRVIEKLPELEIDDGTKKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKV 127
+P P IEK+ + + + VF+G+QTGT E FA ++++A RY
Sbjct: 4 QPAPSTQETSFIEKMKKTG-----RNIVVFYGSQTGTGEEFANRLSKDAH-RY------- 50
Query: 128 VDMDDYAADDDEYE-EKLKK-----ETMALFFLATYGDGEPTDNAARFYKWFEEFEGEED 181
M AAD +EY+ +L + ++A+F +ATYG+G+PTDNA FY W +E +G+
Sbjct: 51 -GMGSMAADPEEYDMSELSRLAEIGNSLAIFCMATYGEGDPTDNAQDFYDWLQETDGQ-- 107
Query: 182 SFKNLQYGVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAK 241
+ Y VF LG++ YEH+N +
Sbjct: 108 -LSGVNYPVFALGDKTYEHYNAM-----------------------------------GA 131
Query: 242 IVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTAS 301
VD +L E G R+ +G+GDDD +E+DF W+E+ WPA+ + E A+ +S
Sbjct: 132 YVDKRLEELGAKRVFDLGMGDDDGNLEEDFVTWREQFWPAMCEHFGVE-----ASGEDSS 186
Query: 302 VLEYRVVIRDQLDATVDEKKQLNG-----NGHAVVDAHHPVRANVAVRKELHTPASDRSC 356
V +Y + + ++ +L DA +P A V V ++L+ A +
Sbjct: 187 VRQYELKEHNDINMNKVYTGELGRLKSFETQKPPFDAKNPFLAPVTVNRKLNK-AGELHK 245
Query: 357 THLEFDISGTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGG 416
HLE DI+G+ + YE+GDHV VY N + V +ILG+ D+ S++ DE+
Sbjct: 246 MHLEVDITGSKIRYESGDHVAVYPTNNTVIVNRLGQILGVDLDSVISLNNLDEE------ 299
Query: 417 SSLPPPFP-PCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLAS--PAGKD 473
S+ PFP P T RTAL Y D++ P+ + L LA +A+D + + +AS P GK
Sbjct: 300 SNKKHPFPCPTTYRTALTHYLDIIHPPRTNVLYELAQYATDLKDQENTDSMASSAPEGKA 359
Query: 474 EYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTC 533
Y +V+ R++L ++ + S +PPI + PRLQ RYYSI+SS +V P+ IH+
Sbjct: 360 LYQSFVLEDNRNILAILEDLPSLRPPID-HLCELMPRLQARYYSIASSSKVHPNSIHICA 418
Query: 534 ALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGP 593
LV +GV +TW+K ++R+S FRLP P+IM+GP
Sbjct: 419 VLVEYXT------KGVATTWLK----------------YIRKSQFRLPFKASNPVIMVGP 456
Query: 594 GTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIV 653
GTG+APF GF+QER LKE G E+G +VL+ GCR+++ DY+Y++EL GAL++L V
Sbjct: 457 GTGIAPFMGFIQERGWLKESGKEVGETVLYCGCRHKEEDYLYQEELEQAHKKGALTKLNV 516
Query: 654 AFSREGPTKEYVQHKMIEKASDIWNMISQG-AYIYVCGDAKGMAKDVHRTLHTILQEQGS 712
AFSRE K YVQH + + D+W I + A+IY+CGDA+ MA+DV + I +E G
Sbjct: 517 AFSREQDQKVYVQHLLRKNKVDLWRQIHEDYAHIYICGDARNMARDVQTAFYEIAEELGG 576
Query: 713 LDNSKTESMVKNLQMTGRYLRDVW 736
+ ++ +K L GRY +DVW
Sbjct: 577 MTRTQATDYIKKLMTKGRYSQDVW 600
>NCPR_ASPNG (Q00141) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 693
Score = 333 bits (853), Expect = 1e-90
Identities = 230/695 (33%), Positives = 338/695 (48%), Gaps = 89/695 (12%)
Query: 76 KRVIEKLPELEIDDGTKKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAA 135
+ +IEK+ E K +F+G+QTGTAE +A +A+E R+ K V D+++Y
Sbjct: 53 RNIIEKMEETG-----KNCVIFYGSQTGTAEDYASRLAKEGSQRFG-LKTMVADLEEY-- 104
Query: 136 DDDEYEEKLKKETMALFFLATYGDGEPTDNAARFYKWF-------EEFEGEEDSFKNLQY 188
D E ++ ++ +A F LATYG+GEPTDNA FY++F E +E L+Y
Sbjct: 105 -DYENLDQFPEDKVAFFVLATYGEGEPTDNAVEFYQFFTGDDVAFESASADEKPLSKLKY 163
Query: 189 GVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLL 248
FGLGN YEH+N + Q VD
Sbjct: 164 VAFGLGNNTYEHYNAMVRQ-----------------------------------VDAAFQ 188
Query: 249 EKGGNRLVPVGLGDDDQ-CIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRV 307
+ G R+ G GDD +E+DF AWKE +W AL + + E+ V P V E
Sbjct: 189 KLGPQRIGSAGEGDDGAGTMEEDFLAWKEPMWAALSESMDLEEREAVYEPVFC-VTENES 247
Query: 308 VIRDQLDATVDEKKQ--LNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISG 365
+ + + E Q L G AH+P A +A +EL T DR+C H+E I+G
Sbjct: 248 LSPEDETVYLGEPTQSHLQGTPKGPYSAHNPFIAPIAESRELFT-VKDRNCLHMEISIAG 306
Query: 366 TGVVYETGDHVGVYCENLSDTVEEAERILGLSP--DTYFSVHTDDEDGKPLGGSSLPPPF 423
+ + Y+TGDH+ V+ N V+ ++ GL D+ ++ D K +P P
Sbjct: 307 SNLSYQTGDHIAVWPTNAGAEVDRFLQVFGLEGKRDSVINIKGIDVTAK------VPIP- 359
Query: 424 PPCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQ 483
P T A+ Y +V + + + LAA A RL + +
Sbjct: 360 TPTTYDAAVRYYMEVCAPVSRQFVATLAAFAPMRKARQRLCVWVAQGLFPREGHQPMLQH 419
Query: 484 RSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTG 543
L+ + + P + + +LQPRYYSISSS V +I +T + ++P G
Sbjct: 420 AQALQSITSKPFSAVPFSLLIEGIT-KLQPRYYSISSSSLVQKDKISITAVVESVRLP-G 477
Query: 544 RIH--QGVCSTWM------KNSAPLEKSQ-------------DCSWAPIFVRQSNFRLPA 582
H +GV + ++ +N L + D P+ VR SNF+LP+
Sbjct: 478 ASHMVKGVTTNYLLALKQKQNGRSLSRPSRLDLLHHGPRNKYDGIHVPVHVRHSNFKLPS 537
Query: 583 DNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHF 642
D PIIM+GPGTG+APFRGF+QER AL +G ++GP+VLFFGCR D++Y+DE +
Sbjct: 538 DPSRPIIMVGPGTGVAPFRGFIQERAALAAKGEKVGPTVLFFGCRKSDEDFLYKDEWKTY 597
Query: 643 VHG-GALSELIVAFSREGPTKEYVQHKMIEKASDIWNMISQGAYIYVCGDAKGMAKDVHR 701
G ++I AFSREGP K YVQH++ E + + +++ Q A YVCGDA MA++V+
Sbjct: 598 QDQLGDNLKIITAFSREGPQKVYVQHRLREHSELVSDLLKQKATFYVCGDAANMAREVNL 657
Query: 702 TLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
L I+ Q L K E MVK+++ GRY DVW
Sbjct: 658 VLGQIIAAQRGLPAEKGEEMVKHMRRRGRYQEDVW 692
>NCPR_CANMA (P50126) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 680
Score = 304 bits (779), Expect = 5e-82
Identities = 208/685 (30%), Positives = 326/685 (47%), Gaps = 102/685 (14%)
Query: 92 KKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMAL 151
K + FG+QTGTAE +A ++ E +R+ K V D DY D D + + + + +
Sbjct: 58 KNTLLLFGSQTGTAEDYANKLSREIHSRFG-LKTMVADFADY--DWDNFGD-IPNDILVF 113
Query: 152 FFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVCTQALMH 211
F +ATYG+GEPTDNA F+ W + E D+ L+Y VFGLGN YE +N +
Sbjct: 114 FIVATYGEGEPTDNADEFHTWLTD---EADTLSTLRYTVFGLGNSTYEFYNAI------- 163
Query: 212 SCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQ-CIEDD 270
+ D L EKGG R G GDD +++D
Sbjct: 164 ----------------------------GRKFDRLLEEKGGERFADYGEGDDGTGTLDED 195
Query: 271 FTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGH-- 328
F WK+ ++ L L E+ P V + ++ D TVD+ + G +
Sbjct: 196 FLTWKDNVFDTLKNDLNFEERELKYEP--------NVKLTERDDLTVDDSEVSLGEPNKK 247
Query: 329 -----------AVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVG 377
D HP A ++ +EL + +R+C H+EFD+S + + Y TGDH+
Sbjct: 248 YIQSEEIDLTKGPFDHTHPYLAKISKTRELFA-SKERNCVHVEFDVSESNLKYTTGDHLA 306
Query: 378 VYCENLSDTVEEAERILGLSP--DTYFSVHTDDEDGKPLGGSSLPPPFP-PCTLRTALAK 434
V+ N + + + + GL +T F + D S+ PFP P T +
Sbjct: 307 VWPSNSDENIAKFIKCFGLDDKINTVFELKALD--------STYQIPFPNPITYGAVVRH 358
Query: 435 YADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAEFS 494
+ ++ + LA+A A D + + K E+A + + ++ + + S
Sbjct: 359 HLEISGPVSRQFFLAIAGFAPDEETKKTFTRIGND--KQEFANKITRKKLNVADALLFAS 416
Query: 495 SAKPPIGVFFASV---APRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCS 551
+ +P V F + P LQPRYYSISSS I++T + ++ GR GV +
Sbjct: 417 NGRPWSDVPFEFIIENVPHLQPRYYSISSSSLSEKQTINITAVVEVEEEADGRAVTGVVT 476
Query: 552 TWMKN------------------SAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGP 593
+KN S P K P+ VR+SNF+LP + P+I+IGP
Sbjct: 477 NLLKNIEIEQNKTGEKPVVHYDLSGPRNKFNKFK-LPVHVRRSNFKLPKNTTTPVILIGP 535
Query: 594 GTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHG-GALSELI 652
GTG+AP RGF++ER+ + G +G +VLF+GCRN D++Y+ E + + G E+
Sbjct: 536 GTGVAPLRGFVRERVQQVKNGVNVGKTVLFYGCRNEHDDFLYKQEWSEYASVLGENFEMF 595
Query: 653 VAFSREGPTKE-YVQHKMIEKASDIWNMISQGAYIYVCGDAKGMAKDVHRTLHTILQEQG 711
AFSR+ P+K+ YVQ K+ E + + +++++GA IYVCGDA MA+DV T+ I+ +
Sbjct: 596 TAFSRQDPSKKVYVQDKIAENSKVVNDLLNEGAIIYVCGDASRMARDVQSTIAKIVAKHR 655
Query: 712 SLDNSKTESMVKNLQMTGRYLRDVW 736
+ K +VK+ ++ RY DVW
Sbjct: 656 EIQEDKAVELVKSWKVQNRYQEDVW 680
>NCPR_YEAST (P16603) NADPH--cytochrome P450 reductase (EC 1.6.2.4)
(CPR) (P450R)
Length = 690
Score = 277 bits (708), Expect = 8e-74
Identities = 211/698 (30%), Positives = 326/698 (46%), Gaps = 108/698 (15%)
Query: 87 IDDGTKKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKK 146
+ + K V + +QTGTAE +AK ++E A++ D+++Y ++E
Sbjct: 53 VTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFN-LNVMCADVENY-----DFESLNDV 106
Query: 147 ETMALFFLATYGDGEPTDNAARFYKWFEEF--EGEEDSFKNLQYGVFGLGNRQYEHFNKV 204
+ F++TYG+G+ D A F E+F E + NL+Y +FGLGN YE FN
Sbjct: 107 PVIVSIFISTYGEGDFPDGAVNF----EDFICNAEAGALSNLRYNMFGLGNSTYEFFNGA 162
Query: 205 CTQALMHSCGFLSFDYSDGVASFRAFSDIYHSTQVAKIVDDKLLEKGGNRLVPVGLGDDD 264
+A H L G RL +G DD
Sbjct: 163 AKKAEKH-----------------------------------LSAAGAIRLGKLGEADDG 187
Query: 265 Q-CIEDDFTAWKEELWPAL-DQLLRDEDDATVATPYTASVLEYRVVIRDQLD-----ATV 317
++D+ AWK+ + L D+L DE +A + + +VL I D + A
Sbjct: 188 AGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNE---ITDSMSLGEPSAHY 244
Query: 318 DEKKQLNGNGHAV----VDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETG 373
QLN N + D P A + +EL + ++DR+C H EFD+SG+ + Y TG
Sbjct: 245 LPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFS-SNDRNCIHSEFDLSGSNIKYSTG 303
Query: 374 DHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFP-PCTLRTAL 432
DH+ V+ N + VE+ I L P+T F D KPL ++ PFP P T+ A+
Sbjct: 304 DHLAVWPSNPLEKVEQFLSIFNLDPETIF-------DLKPL-DPTVKVPFPTPTTIGAAI 355
Query: 433 AKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAE 492
Y ++ + +L A + ++L L+ KD++A + + ++ + +
Sbjct: 356 KHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSK--DKDQFAVEITSKYFNIADALKY 413
Query: 493 FSSAKPPIGV---FFASVAPRLQPRYYSISSSPRVAPSRIHVTCAL---VHDKMPTGRIH 546
S V F P++ PRYYSISSS +HVT + + ++P
Sbjct: 414 LSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPV 473
Query: 547 QGVCSTWMKNSAPLEKSQDCSWA--------------------PIFVRQSNFRLPADNKV 586
GV + ++N + + + + P+ VR+SNFRLP++
Sbjct: 474 VGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPST 533
Query: 587 PIIMIGPGTGLAPFRGFLQERLALKE------EGAELGPSVLFFGCRNRQVDYIYEDELN 640
P+IMIGPGTG+APFRGF++ER+A E LG +LF+G RN D++Y+DE
Sbjct: 534 PVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTD-DFLYQDEWP 592
Query: 641 HFVHG-GALSELIVAFSREGPTKE-YVQHKMIEKASDIWNMISQGAYIYVCGDAKGMAKD 698
+ E++VA SR TK+ YVQ K+ + ++ MI+ GA+IYVCGDAKGMAK
Sbjct: 593 EYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKG 652
Query: 699 VHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
V L IL S+ + ++K L+ +GRY DVW
Sbjct: 653 VSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW 690
>NOS1_RABIT (O19132) Nitric-oxide synthase, brain (EC 1.14.13.39)
(NOS, type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive
NOS) (NC-NOS) (bNOS)
Length = 1435
Score = 259 bits (661), Expect = 2e-68
Identities = 209/696 (30%), Positives = 317/696 (45%), Gaps = 106/696 (15%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K T+ + T+TG ++ +AK + E K ++ KV+ M++Y L+ ET+ L
Sbjct: 760 KATILYATETGKSQAYAKTLCEIFKHAFDA---KVMSMEEYDI------VHLEHETLVLV 810
Query: 153 FLATYGDGEPTDNAARF-------------------YKW-FEEFEGEEDSFK-------- 184
+T+G+G+P +N +F YK F DS K
Sbjct: 811 VTSTFGNGDPPENGEKFRCALMEMRHPNSLQEERKSYKVRFNSVSSYSDSRKSSGDGPDV 870
Query: 185 -----------NLQYGVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDI 233
N+++ VFGLG+R Y HF C F
Sbjct: 871 RDHFESAGPLANVRFSVFGLGSRAYPHF-----------CAF------------------ 901
Query: 234 YHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDAT 293
VD L E GG R++ + GD+ E+ F W ++++ A + DD
Sbjct: 902 ------GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVN 955
Query: 294 VATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGHAVVDAHHPVRANVAVRKELHTPASD 353
+ + + R R++ T + G + V A + R+ L +P S
Sbjct: 956 IEKANNSLISNDRSWKRNKFRLTYVAEAPGLTQGLSSVHKKRVSAARLLSRQNLQSPKSS 1015
Query: 354 RSCTHLEFDISGTGVV-YETGDHVGVYCENLSDTVEEA-ERILGLSP-DTYFSVHTDDED 410
RS + +G+ + Y+ GDH+GV+ N D V ER+ P + V +E
Sbjct: 1016 RSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANQMVKVELLEER 1075
Query: 411 GKPLGGSSL---PPPFPPCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLA 467
LG S P PPCT+ A Y D+ + P L A+ AS+ E RL L+
Sbjct: 1076 NTALGVISNWKDEPRLPPCTVFQAFKYYLDITTPPTPLQLQQFASLASNEKEKQRLLVLS 1135
Query: 468 SPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPS 527
G EY EW +++EV+ EF S + P + ++ LQPRYYSISSSP + P
Sbjct: 1136 K--GLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLS-LLQPRYYSISSSPDMYPD 1192
Query: 528 RIHVTCALV--HDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADN 584
+H+T A+V H + G IH GVCS+W+ N P ++ C FVR + +FRLP +
Sbjct: 1193 EVHLTVAIVSYHTRDGEGPIHHGVCSSWL-NRIPADEVVPC-----FVRGAPSFRLPRNP 1246
Query: 585 KVPIIMIGPGTGLAPFRGFLQER-LALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFV 643
+VP I++GPGT APFR F Q+R ++ +G P VL FGCR ++D+IY +E
Sbjct: 1247 QVPCILVGPGTAFAPFRSFWQQRQFDIQHKGMSPCPMVLVFGCRQSKIDHIYREEALQAK 1306
Query: 644 HGGALSELIVAFSRE-GPTKEYVQHKMIEK-ASDIWNMI-SQGAYIYVCGDAKGMAKDVH 700
+ G EL A+SRE K+YVQ + E+ A ++ + QG +IYVCGD MA DV
Sbjct: 1307 NKGVFRELYTAYSREPDKPKKYVQDILQEQLAEQVYRALKEQGGHIYVCGDVT-MAADVL 1365
Query: 701 RTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
+ + I+ +QG L + L+ RY D++
Sbjct: 1366 KAVQRIMAQQGKLSAEDAGVFISRLRDDNRYHEDIF 1401
>NOS3_HUMAN (P29474) Nitric-oxide synthase, endothelial (EC
1.14.13.39) (EC-NOS) (NOS, type III) (NOSIII)
(Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS)
Length = 1202
Score = 254 bits (650), Expect = 4e-67
Identities = 205/669 (30%), Positives = 320/669 (47%), Gaps = 52/669 (7%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K T+ +G++TG A+ +A+ + + ++ +V+ MD+Y L+ ET+ L
Sbjct: 518 KATILYGSETGRAQSYAQQLGRLFRKAFDP---RVLCMDEYDV------VSLEHETLVLV 568
Query: 153 FLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYE-HFNKV-CTQALM 210
+T+G+G+P +N F E G +S + ++ Y+ FN + C+ L+
Sbjct: 569 VTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQ------HKSYKIRFNSISCSDPLV 622
Query: 211 HSCGFLSFDYSD-------GVASFRAF---SDIY-HSTQVAKIVDDKLLEKGGNRLVPVG 259
S + S+ G F F S Y H A+ VD +L E GG RL+ +G
Sbjct: 623 SSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLG 682
Query: 260 LGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDE 319
GD+ E+ F W + + A + +DA A S R +L A +
Sbjct: 683 QGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEG 742
Query: 320 KKQLNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGT-GVVYETGDHVGV 378
+ L G H V +A + + L + S R+ + D G G+ Y+ GDH+GV
Sbjct: 743 LQLLPGLIH--VHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGV 800
Query: 379 YCENLSDTVEEAERILGLSPDTYFSVHTDD-EDGKPLG---GSSLPPPFPPCTLRTALAK 434
N VE + P V + E G P G G P PPCTLR AL
Sbjct: 801 CPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTF 860
Query: 435 YADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAEFS 494
+ D+ S P L L+ A +P E L L+ + Y EW +LLEV+ +F
Sbjct: 861 FLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRR--YEEWKWFRCPTLLEVLEQFP 918
Query: 495 SAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGR--IHQGVCST 552
S P + + P LQPRYYS+SS+P P IH+T A++ + G +H GVCST
Sbjct: 919 SVALPAPLLLTQL-PLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCST 977
Query: 553 WMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADNKVPIIMIGPGTGLAPFRGFLQERL-AL 610
W+ P + P F+R + +FRLP D +P I++GPGTG+APFRGF QERL +
Sbjct: 978 WLSQLKPGDP------VPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDI 1031
Query: 611 KEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPT-KEYVQHKM 669
+ +G + P L FGCR Q+D++Y DE+ + G ++ AFSRE K YVQ +
Sbjct: 1032 ESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDIL 1091
Query: 670 -IEKASDIWNMIS-QGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQM 727
E A+++ ++ + +++VCGD MA +V +T+ IL +G ++ + ++ L+
Sbjct: 1092 RTELAAEVHRVLCLERGHMFVCGDVT-MATNVLQTVQRILATEGDMELDEAGDVIGVLRD 1150
Query: 728 TGRYLRDVW 736
RY D++
Sbjct: 1151 QQRYHEDIF 1159
>NOS3_MOUSE (P70313) Nitric-oxide synthase, endothelial (EC
1.14.13.39) (EC-NOS) (NOS, type III) (NOSIII)
(Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS)
Length = 1201
Score = 254 bits (648), Expect = 7e-67
Identities = 207/669 (30%), Positives = 320/669 (46%), Gaps = 52/669 (7%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K T+ +G++TG A+ +A+ + + ++ +V+ MD+Y L+ E + L
Sbjct: 517 KATILYGSETGRAQSYAQQLGRLFRKAFDP---RVLCMDEYDV------VSLEHEALVLV 567
Query: 153 FLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYE-HFNKV-CTQALM 210
+T+G+G+P +N F E G +S + ++ Y+ FN V C+ L+
Sbjct: 568 VTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQ------HKSYKIRFNSVSCSDPLV 621
Query: 211 HSCGFLSFDYSD-------GVASFRAF---SDIY-HSTQVAKIVDDKLLEKGGNRLVPVG 259
S + S+ G F F S Y H A+ VD +L E GG RL+ +G
Sbjct: 622 SSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLG 681
Query: 260 LGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDE 319
GD+ E+ F W + + A + +DA A S R +L +
Sbjct: 682 QGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAES 741
Query: 320 KKQLNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGT-GVVYETGDHVGV 378
+ L G H V +A + + L + S R+ + D G G+ Y+ GDH+GV
Sbjct: 742 LQLLPGLTH--VHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGV 799
Query: 379 YCENLSDTVEEA-ERILGLSPDTYFSVHTDDEDGKPLG---GSSLPPPFPPCTLRTALAK 434
N VE R+ P T E G P G G P PPCTLR AL
Sbjct: 800 CPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTY 859
Query: 435 YADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAEFS 494
+ D+ S P L L+ A + SE L L+ + Y EW S +LLEV+ +F
Sbjct: 860 FLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRR--YEEWKWFSCPTLLEVLEQFP 917
Query: 495 SAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGR--IHQGVCST 552
S P + + P LQPRYYS+SS+P P IH+T A++ + G +H GVCST
Sbjct: 918 SVALPAPLILTQL-PLLQPRYYSVSSAPSAHPGEIHLTIAVLAYRTQDGLGPLHYGVCST 976
Query: 553 WMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADNKVPIIMIGPGTGLAPFRGFLQERL-AL 610
WM K+ D P F+R + +FRLP D +P I++GPGTG+APFRGF Q+RL +
Sbjct: 977 WMSQL----KAGDP--VPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDI 1030
Query: 611 KEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSRE-GPTKEYVQHKM 669
+ +G + P L FGCR Q+D++Y DE+ G +++ AFSR+ G K YVQ +
Sbjct: 1031 EIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLL 1090
Query: 670 -IEKASDIWNMIS-QGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQM 727
E A+++ ++ + +++VCGD MA V +T+ IL +G ++ + ++ L+
Sbjct: 1091 RTELAAEVHRVLCLEQGHMFVCGDVT-MATSVLQTVQRILATEGGMELDEAGDVIGVLRD 1149
Query: 728 TGRYLRDVW 736
RY D++
Sbjct: 1150 QQRYHEDIF 1158
>NOS1_RAT (P29476) Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS,
type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS)
(NC-NOS) (BNOS)
Length = 1429
Score = 253 bits (647), Expect = 1e-66
Identities = 204/696 (29%), Positives = 312/696 (44%), Gaps = 106/696 (15%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K T+ + T+TG ++ +AK + E K ++ K + M++Y L+ E + L
Sbjct: 754 KATILYATETGKSQAYAKTLCEIFKHAFDA---KAMSMEEYDI------VHLEHEALVLV 804
Query: 153 FLATYGDGEPTDNAARF-------------------YKW-FEEFEGEEDSFK-------- 184
+T+G+G+P +N +F YK F DS K
Sbjct: 805 VTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDL 864
Query: 185 -----------NLQYGVFGLGNRQYEHFNKVCTQALMHSCGFLSFDYSDGVASFRAFSDI 233
N+++ VFGLG+R Y HF C F
Sbjct: 865 RDNFESTGPLANVRFSVFGLGSRAYPHF-----------CAF------------------ 895
Query: 234 YHSTQVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDAT 293
VD L E GG R++ + GD+ E+ F W ++++ A + DD
Sbjct: 896 ------GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVN 949
Query: 294 VATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGHAVVDAHHPVRANVAVRKELHTPASD 353
+ P + + R R++ T + G + V A + R+ L +P
Sbjct: 950 IEKPNNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFS 1009
Query: 354 RSCTHLEFDISGTGVV-YETGDHVGVYCENLSDTVEEA-ERILGLSPDTYF-SVHTDDED 410
RS + +G + Y+ GDH+GV+ N D V ER+ P + V +E
Sbjct: 1010 RSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEER 1069
Query: 411 GKPLGGSSL---PPPFPPCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLA 467
LG S PPCT+ A Y D+ + P L A+ A++ E RL L+
Sbjct: 1070 NTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLS 1129
Query: 468 SPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPS 527
G EY EW +++EV+ EF S + P + ++ LQPRYYSISSSP + P
Sbjct: 1130 K--GLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLS-LLQPRYYSISSSPDMYPD 1186
Query: 528 RIHVTCALV--HDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADN 584
+H+T A+V H + G +H GVCS+W L + Q P FVR + +F LP +
Sbjct: 1187 EVHLTVAIVSYHTRDGEGPVHHGVCSSW------LNRIQADDVVPCFVRGAPSFHLPRNP 1240
Query: 585 KVPIIMIGPGTGLAPFRGFLQER-LALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFV 643
+VP I++GPGTG+APFR F Q+R ++ +G P VL FGCR ++D+IY +E
Sbjct: 1241 QVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAK 1300
Query: 644 HGGALSELIVAFSRE-GPTKEYVQHKMIEK-ASDIWNMI-SQGAYIYVCGDAKGMAKDVH 700
+ G EL A+SRE K+YVQ + E+ A ++ + QG +IYVCGD MA DV
Sbjct: 1301 NKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVT-MAADVL 1359
Query: 701 RTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW 736
+ + I+ +QG L + L+ RY D++
Sbjct: 1360 KAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIF 1395
>NOS3_BOVIN (P29473) Nitric-oxide synthase, endothelial (EC
1.14.13.39) (EC-NOS) (NOS, type III) (NOSIII)
(Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS)
Length = 1204
Score = 249 bits (637), Expect = 1e-65
Identities = 206/673 (30%), Positives = 320/673 (46%), Gaps = 60/673 (8%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K T+ + ++TG A+ +A+ + + ++ +V+ MD+Y L+ E + L
Sbjct: 520 KATILYASETGRAQSYAQQLGRLFRKAFDP---RVLCMDEYDV------VSLEHEALVLV 570
Query: 153 FLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYE-HFNKV-CTQALM 210
+T+G+G+P +N F E G +S + ++ Y+ FN V C+ L+
Sbjct: 571 VTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQ------HKSYKIRFNSVSCSDPLV 624
Query: 211 HSCGFLSFDYSD-------GVASFRAF---SDIY-HSTQVAKIVDDKLLEKGGNRLVPVG 259
S + S+ G F F S Y H A+ VD +L E GG RL+ +G
Sbjct: 625 SSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLG 684
Query: 260 LGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDE 319
GD+ E+ F W + + A + ++A A S R +L +
Sbjct: 685 QGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKAAAQDIFSPKRSWKRQRYRLSTQAEG 744
Query: 320 KKQLNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGT-GVVYETGDHVGV 378
+ L G H V +A V + L + S R+ + D +G G+ Y+ GDH+G+
Sbjct: 745 LQLLPGLIH--VHRRKMFQATVLSVENLQSSKSTRATILVRLDTAGQEGLQYQPGDHIGI 802
Query: 379 YCENLSDTVEEA-ERILGLSPDTYFSVHTDDEDGKPLGGSSLPPP-------FPPCTLRT 430
N VE R+ P T E G P G PPP PPCTLR
Sbjct: 803 CPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPGG----PPPSWVRDPRLPPCTLRQ 858
Query: 431 ALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVM 490
AL + D+ S P L L+ A +PSE L L+ + Y EW +LLEV+
Sbjct: 859 ALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPRR--YEEWKWFRCPTLLEVL 916
Query: 491 AEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGR--IHQG 548
+F S P + + P LQPRYYS+SS+P P +H+T A++ + G +H G
Sbjct: 917 EQFPSVALPAPLLLTQL-PLLQPRYYSVSSAPNAHPGEVHLTVAVLAYRTQDGLGPLHYG 975
Query: 549 VCSTWMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADNKVPIIMIGPGTGLAPFRGFLQER 607
VCSTW+ K+ D P F+R + +FRLP D VP I++GPGTG+APFRGF QER
Sbjct: 976 VCSTWLSQL----KTGDP--VPCFIRGAPSFRLPPDPYVPCILVGPGTGIAPFRGFWQER 1029
Query: 608 L-ALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPT-KEYV 665
L ++ +G + P L FGCR Q+D++Y DE+ G ++ AFSRE + K YV
Sbjct: 1030 LHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFSREPDSPKTYV 1089
Query: 666 QHKM-IEKASDIWNMIS-QGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVK 723
Q + E A+++ ++ + +++VCGD MA V +T+ IL +G ++ + ++
Sbjct: 1090 QDILRTELAAEVHRVLCLERGHMFVCGDVT-MATSVLQTVQRILATEGDMELDEAGDVIG 1148
Query: 724 NLQMTGRYLRDVW 736
L+ RY D++
Sbjct: 1149 VLRDQQRYHEDIF 1161
>NOS3_PIG (Q28969) Nitric-oxide synthase, endothelial (EC 1.14.13.39)
(EC-NOS) (NOS, type III) (NOSIII) (Endothelial NOS)
(eNOS) (Constitutive NOS) (cNOS)
Length = 1204
Score = 247 bits (631), Expect = 7e-65
Identities = 206/673 (30%), Positives = 320/673 (46%), Gaps = 60/673 (8%)
Query: 93 KVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALF 152
K ++ + ++T A+ +A+ + + ++ +V+ MD+Y L+ ET+ L
Sbjct: 520 KASILYASETVRAQSYAQQLGRLFRKAFDP---RVLCMDEYDV------VSLEHETLVLV 570
Query: 153 FLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYE-HFNKV-CTQALM 210
+T+G+G+P +N F E G + + +R Y+ FN V C+ L+
Sbjct: 571 VTSTFGNGDPPENGESFAAALMEMSGPYNGSPRPEQ------HRSYKIRFNSVSCSDPLV 624
Query: 211 HSCGFLSFDYSD-------GVASFRAF---SDIY-HSTQVAKIVDDKLLEKGGNRLVPVG 259
S + S+ G F F S Y H A+ VD +L E GG RL+ +G
Sbjct: 625 SSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLG 684
Query: 260 LGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDE 319
GD+ E+ F W + + A + +DA A S R +L A V+
Sbjct: 685 QGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQVEG 744
Query: 320 KKQLNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGT-GVVYETGDHVGV 378
+ L G H V +A V + L + S R+ + D G G+ Y+ GDH+G+
Sbjct: 745 LQLLPGLVH--VHRRKMFQATVLSVENLQSSKSTRATILVRLDTEGQEGLQYQPGDHIGI 802
Query: 379 YCENLSDTVEEA-ERILGLSPDTYFSVHTDDEDGKPLGGSSLPPP-------FPPCTLRT 430
N + VE R+ +P T E G P G PPP PP TLR
Sbjct: 803 CPPNRTGLVEALLSRVEDPTPPTESVGVEQLEKGSPGG----PPPSWVRDPRLPPYTLRQ 858
Query: 431 ALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVM 490
AL + D+ S P L L+ A +PSE L L+ + Y EW +LLEV+
Sbjct: 859 ALTFFLDITSPPSPRLLRVLSTLAEEPSEQQELETLSQDPRR--YEEWKWFRCPTLLEVL 916
Query: 491 AEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGR--IHQG 548
+F S P + +A LQPRYYS+SS+P P IH T A++ + G +H G
Sbjct: 917 EQFPSVALPTPLLLTQLA-LLQPRYYSVSSAPSTYPGEIHPTVAVLAYRTQDGLGPLHYG 975
Query: 549 VCSTWMKNSAPLEKSQDCSWAPIFVRQS-NFRLPADNKVPIIMIGPGTGLAPFRGFLQER 607
VCSTW+ P + P F+R + +FRLP D +P I++GPGTG+APFRGF QER
Sbjct: 976 VCSTWLGQLKPGDP------VPCFIRAAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQER 1029
Query: 608 L-ALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPT-KEYV 665
L ++ +G + P L FGCR Q+D++Y DE+ G ++ AFSRE + K YV
Sbjct: 1030 LHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSREPDSPKTYV 1089
Query: 666 QHKM-IEKASDIWNMIS-QGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVK 723
Q + E A+++ ++ + +++VCGD MA V +T+ IL +G+++ + ++
Sbjct: 1090 QDILRTELAAEVHRVLCLERGHMFVCGDVT-MATSVLQTVQRILATEGNMELDEAGDVIG 1148
Query: 724 NLQMTGRYLRDVW 736
L+ RY D++
Sbjct: 1149 VLRDQQRYHEDIF 1161
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,384,135
Number of Sequences: 164201
Number of extensions: 4220360
Number of successful extensions: 11286
Number of sequences better than 10.0: 129
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 10745
Number of HSP's gapped (non-prelim): 210
length of query: 736
length of database: 59,974,054
effective HSP length: 118
effective length of query: 618
effective length of database: 40,598,336
effective search space: 25089771648
effective search space used: 25089771648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Medicago: description of AC135801.5