BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC135797.12 - phase: 0
(280 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
I5P2_HUMAN (P32019) Type II inositol-1,4,5-trisphosphate 5-phosp... 164 2e-40
OCRL_HUMAN (Q01968) Inositol polyphosphate 5-phosphatase OCRL-1 ... 161 2e-39
SYJ1_HUMAN (O43426) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 155 1e-37
SYJ1_BOVIN (O18964) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 155 1e-37
SYJ1_RAT (Q62910) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosito... 154 2e-37
SYJ1_MOUSE (Q8CHC4) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 154 2e-37
SYJ2_MOUSE (Q9D2G5) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosi... 153 5e-37
YNK6_YEAST (P50942) Hypothetical 133.3 kDa protein in CYB5-LEU4 ... 152 7e-37
SYJ2_RAT (O55207) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosito... 151 1e-36
SYJ2_HUMAN (O15056) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosi... 149 6e-36
YIA2_YEAST (P40559) Hypothetical 108.4 kDa protein in BET1-PAN1 ... 139 6e-33
SYJ1_SCHPO (O43001) Synaptojanin homolog 1 (EC 3.1.3.36) (Inosit... 132 9e-31
P5PA_RAT (Q9JMC1) Phosphatidylinositol 4,5-bisphosphate 5-phosph... 114 2e-25
P5PA_MOUSE (P59644) Phosphatidylinositol 4,5-bisphosphate 5-phos... 114 2e-25
INP5_MOUSE (Q9JII1) 72 kDa inositol polyphosphate 5-phosphatase ... 114 3e-25
INP5_RAT (Q9WVR1) 72 kDa inositol polyphosphate 5-phosphatase (E... 113 5e-25
P5PA_HUMAN (Q15735) Phosphatidylinositol 4,5-bisphosphate 5-phos... 112 1e-24
INP5_HUMAN (Q9NRR6) 72 kDa inositol polyphosphate 5-phosphatase ... 109 9e-24
SKIP_HUMAN (Q9BT40) Skeletal muscle and kidney enriched inositol... 108 2e-23
SKIP_MOUSE (Q8C5L6) Skeletal muscle and kidney enriched inositol... 102 1e-21
>I5P2_HUMAN (P32019) Type II inositol-1,4,5-trisphosphate
5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide
5-phosphatase) (5PTase) (Fragment)
Length = 942
Score = 164 bits (416), Expect = 2e-40
Identities = 93/242 (38%), Positives = 138/242 (56%), Gaps = 15/242 (6%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VGI L ++V+ ++ ++ ++ VGTGIMG +GNKG ++I + + T+ C V +HLA+
Sbjct: 373 LVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAA 432
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSH------SLGILEHDNIIWLGDLNYRL-AAGYDEIH 113
+ RRN D +I R +F L I HD I+WLGDLNYR+ +++
Sbjct: 433 --HIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVK 490
Query: 114 ELLKNNNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEK 173
+L++ + + L DQL+++ A +FEG+ EG + F PTYKY SD + + EK
Sbjct: 491 KLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDW-----DTSEK 545
Query: 174 RRTPAWCDRILWKGEGLNQKMYVRGES-KFSDHRPVYSLFTAQVDMTNKNLTRSASTTIS 232
R PAWCDRILWKG+ + Q Y + K SDH+PV S+F V + N L R I
Sbjct: 546 CRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 605
Query: 233 RS 234
RS
Sbjct: 606 RS 607
>OCRL_HUMAN (Q01968) Inositol polyphosphate 5-phosphatase OCRL-1 (EC
3.1.3.36) (Lowe's oculocerebrorenal syndrome protein)
Length = 901
Score = 161 bits (407), Expect = 2e-39
Identities = 92/233 (39%), Positives = 134/233 (57%), Gaps = 15/233 (6%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L ++ R D ++ ++ VGTGIMG +GNKG +++ + TTFC V +HLA+
Sbjct: 319 LVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAA 378
Query: 61 GEKCGDELRRNLDIAEIIKRTKF------SHSLGILEHDNIIWLGDLNYRLA-AGYDEIH 113
+ D RRN D +I R F L I++H+ +IWLGDLNYRL +E+
Sbjct: 379 HVE--DFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVK 436
Query: 114 ELLKNNNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEK 173
L+ +L+ LL+ DQL +++ + F +NEG I F PTYKY +D++ S K
Sbjct: 437 SLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRW-----DSSGK 491
Query: 174 RRTPAWCDRILWKGEGLNQKMY-VRGESKFSDHRPVYSLFTAQVDMTNKNLTR 225
R PAWCDRILW+G +NQ Y E K SDH+PV +LF V + ++ R
Sbjct: 492 CRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYR 544
>SYJ1_HUMAN (O43426) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1575
Score = 155 bits (392), Expect = 1e-37
Identities = 88/245 (35%), Positives = 129/245 (51%), Gaps = 36/245 (14%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L V++R + + ++ V V TG+ G GNKG+++I M + T+ CFVC+H A+
Sbjct: 633 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI ++ F + HD + W GD NYR+ +E+ EL++ N
Sbjct: 693 GQSQVKE--RNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQN 750
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
+L+ DQL ++NAG++F G+ EG + FAPTYKY + SD Y + EK RTPAW
Sbjct: 751 WDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDY-----DTSEKCRTPAWT 805
Query: 181 DRILWKG------------EGLNQKM-----------------YVRGESKFSDHRPVYSL 211
DR+LW+ + LN Y R E K SDHRPV +L
Sbjct: 806 DRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVAL 865
Query: 212 FTAQV 216
+
Sbjct: 866 IDIDI 870
>SYJ1_BOVIN (O18964) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1) (p150)
(Fragment)
Length = 1324
Score = 155 bits (391), Expect = 1e-37
Identities = 89/245 (36%), Positives = 129/245 (52%), Gaps = 36/245 (14%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L V++R + + ++ V V TG+ G GNKG+++I M + T+ CFVC+H A+
Sbjct: 633 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI ++ F + HD + W GD NYR+ +E+ EL++ N
Sbjct: 693 GQSQVKE--RNDDFLEIARKLSFPMGRLLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQN 750
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
+L+ DQL ++NAG+IF G+ EG + FAPTYKY + SD Y + EK RTPAW
Sbjct: 751 WDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSDDY-----DTSEKCRTPAWT 805
Query: 181 DRILWKG------------EGLNQKM-----------------YVRGESKFSDHRPVYSL 211
DR+LW+ + LN Y R E K SDHRPV +L
Sbjct: 806 DRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVAL 865
Query: 212 FTAQV 216
+
Sbjct: 866 IDIDI 870
>SYJ1_RAT (Q62910) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1574
Score = 154 bits (390), Expect = 2e-37
Identities = 88/245 (35%), Positives = 129/245 (51%), Gaps = 36/245 (14%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L V++R + + ++ V V TG+ G GNKG+++I M + T+ CFVC+H A+
Sbjct: 633 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI ++ F + HD + W GD NYR+ +E+ EL++ N
Sbjct: 693 GQSQVKE--RNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQN 750
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
+L+ DQL ++NAG+IF G+ EG + FAPTYKY + S+ Y + EK RTPAW
Sbjct: 751 WDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDY-----DTSEKCRTPAWT 805
Query: 181 DRILWKG------------EGLNQKM-----------------YVRGESKFSDHRPVYSL 211
DR+LW+ + LN Y R E K SDHRPV +L
Sbjct: 806 DRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVAL 865
Query: 212 FTAQV 216
+
Sbjct: 866 IDIDI 870
>SYJ1_MOUSE (Q8CHC4) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1574
Score = 154 bits (390), Expect = 2e-37
Identities = 88/245 (35%), Positives = 129/245 (51%), Gaps = 36/245 (14%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L V++R + + ++ V V TG+ G GNKG+++I M + T+ CFVC+H A+
Sbjct: 633 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI ++ F + HD + W GD NYR+ +E+ EL++ N
Sbjct: 693 GQSQVKE--RNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQN 750
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
+L+ DQL ++NAG+IF G+ EG + FAPTYKY + S+ Y + EK RTPAW
Sbjct: 751 WDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDY-----DTSEKCRTPAWT 805
Query: 181 DRILWKG------------EGLNQKM-----------------YVRGESKFSDHRPVYSL 211
DR+LW+ + LN Y R E K SDHRPV +L
Sbjct: 806 DRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVAL 865
Query: 212 FTAQV 216
+
Sbjct: 866 IDIDI 870
>SYJ2_MOUSE (Q9D2G5) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2)
Length = 1434
Score = 153 bits (386), Expect = 5e-37
Identities = 87/246 (35%), Positives = 133/246 (53%), Gaps = 38/246 (15%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L ++VR + + ++ + V TG+ G GNKG++ I +L+ T+FCFVC+HL +
Sbjct: 629 LVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLHSTSFCFVCSHLTA 688
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI + F I HD + W GD NYR+ Y+E+ +K +
Sbjct: 689 GQSQVKE--RNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQD 746
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
K L+E DQL++++++G+IF+ ++EG++ F PTYKY + S Y + +K RTPAW
Sbjct: 747 WKKLMEFDQLQLQKSSGKIFKDFHEGAVNFGPTYKYDVGSAAY-----DTSDKCRTPAWT 801
Query: 181 DRILW----------KGEGLN--------------------QKMYVRGESKFSDHRPVYS 210
DR+LW GE LN K Y R E + SDHRPV +
Sbjct: 802 DRVLWWRKKHPYDKTAGE-LNLLDSDLDGDPQIRHTWSPGTLKYYGRAELQASDHRPVLA 860
Query: 211 LFTAQV 216
+ +V
Sbjct: 861 IVEVEV 866
>YNK6_YEAST (P50942) Hypothetical 133.3 kDa protein in CYB5-LEU4
intergenic region
Length = 1183
Score = 152 bits (385), Expect = 7e-37
Identities = 87/224 (38%), Positives = 124/224 (54%), Gaps = 10/224 (4%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M + + + R+D ++ + S TG G GNKG+++I T+FCFV THL++
Sbjct: 674 MSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSA 733
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELL---K 117
G DE RRN D I + F S I HD++ WLGDLNYR+ DE+ L K
Sbjct: 734 GASNIDE-RRN-DYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQK 791
Query: 118 NNNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTP 177
+ + LL+ DQL E N G +F+G+ E ++ F PTYKY +D Y + EK RTP
Sbjct: 792 DGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNY-----DTSEKARTP 846
Query: 178 AWCDRILWKGEGLNQKMYVRGESKFSDHRPVYSLFTAQVDMTNK 221
+W DRI++KGE L+ Y K SDH+PVY+ + A V ++
Sbjct: 847 SWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDE 890
>SYJ2_RAT (O55207) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2)
Length = 1248
Score = 151 bits (382), Expect = 1e-36
Identities = 86/246 (34%), Positives = 132/246 (52%), Gaps = 38/246 (15%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L ++VR + + ++ + V TG+ G GNKG++ I + + T+FCF+C+HL +
Sbjct: 646 LVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTA 705
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI + F I HD + W GD NYR+ Y+E+ +K +
Sbjct: 706 GQSQVKE--RNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQD 763
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
K L+E DQL++++++G+IF+ ++EG+I F PTYKY + S Y + +K RTPAW
Sbjct: 764 WKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAY-----DTSDKCRTPAWT 818
Query: 181 DRILW----------KGEGLN--------------------QKMYVRGESKFSDHRPVYS 210
DR+LW GE LN K Y R E + SDHRPV +
Sbjct: 819 DRVLWWRKKHPYDKTAGE-LNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLA 877
Query: 211 LFTAQV 216
+ +V
Sbjct: 878 IVEVEV 883
>SYJ2_HUMAN (O15056) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2) (Fragment)
Length = 1443
Score = 149 bits (377), Expect = 6e-36
Identities = 85/246 (34%), Positives = 133/246 (53%), Gaps = 38/246 (15%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG+ L ++VR + + ++ + V TG+ G GNKG++ I + + T+FCF+C+HL +
Sbjct: 576 LVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTA 635
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G+ E RN D EI ++ F + HD + W GD NYR+ Y+E+ +K +
Sbjct: 636 GQSQVKE--RNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQD 693
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
K LLE DQL++++++G+IF+ ++EG+I F PTYKY + S Y + +K RTPAW
Sbjct: 694 WKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAY-----DTSDKCRTPAWT 748
Query: 181 DRILW----------KGEGLN--------------------QKMYVRGESKFSDHRPVYS 210
DR+LW GE LN + Y R E + SDHRPV +
Sbjct: 749 DRVLWWRKKHPFDKTAGE-LNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLA 807
Query: 211 LFTAQV 216
+ +V
Sbjct: 808 IVEVEV 813
>YIA2_YEAST (P40559) Hypothetical 108.4 kDa protein in BET1-PAN1
intergenic region
Length = 946
Score = 139 bits (351), Expect = 6e-33
Identities = 82/230 (35%), Positives = 126/230 (54%), Gaps = 8/230 (3%)
Query: 3 GIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLASGE 62
GI L +++ + V +++ TG G NKG++++S + T FC + +HLA+G
Sbjct: 617 GILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGL 676
Query: 63 KCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNNLK 122
+ ++ R+ D I K +FS L I +HD IIW+GD NYR+ +++ + +
Sbjct: 677 ENVEQ--RHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYA 734
Query: 123 ALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWCDR 182
+L EKDQL + AG F ++E +I F PTYK+ + Y + EK R PAW DR
Sbjct: 735 SLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNY-----DTSEKMRIPAWTDR 789
Query: 183 ILWKGEGLNQKMYVRGES-KFSDHRPVYSLFTAQVDMTNKNLTRSASTTI 231
IL +GE L Q Y E FSDHRPVY++F A+V + ++ + T I
Sbjct: 790 ILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQI 839
>SYJ1_SCHPO (O43001) Synaptojanin homolog 1 (EC 3.1.3.36)
(Inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1076
Score = 132 bits (332), Expect = 9e-31
Identities = 73/216 (33%), Positives = 114/216 (51%), Gaps = 8/216 (3%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
+VG L ++ + + N++ + TG+ G GNKG+++I T CF+ +HLA+
Sbjct: 643 LVGTALMIFCKESCLPSIKNVEGTVKKTGLGGVSGNKGAVAIRFDYEDTGLCFITSHLAA 702
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYDEIHELLKNNN 120
G DE R+ D I +F I HD ++W GD NYR++ Y+E+ +
Sbjct: 703 GYTNYDE--RDHDYRTIASGLRFRRGRSIFNHDYVVWFGDFNYRISLTYEEVVPCIAQGK 760
Query: 121 LKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAWC 180
L L E DQL + G++F ++E I F PTYK+ + +D Y + +K R PAW
Sbjct: 761 LSYLFEYDQLNKQMLTGKVFPFFSELPITFPPTYKFDIGTDIY-----DTSDKHRVPAWT 815
Query: 181 DRILWKGEGLNQKMYVRGESKFSDHRPVYSLFTAQV 216
DRIL++GE L Y +SDHRP+Y+ + A +
Sbjct: 816 DRILYRGE-LVPHSYQSVPLYYSDHRPIYATYEANI 850
>P5PA_RAT (Q9JMC1) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56) (Proline-rich inositol
polyphosphate 5-phosphatase)
Length = 1001
Score = 114 bits (286), Expect = 2e-25
Identities = 71/234 (30%), Positives = 119/234 (50%), Gaps = 25/234 (10%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M G+ L ++ + + + +++ TG+ GY GNKG +S+ + + CF+ HL +
Sbjct: 499 MQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPA 558
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYD--EIHELLKN 118
++ + N +++ + + GIL+HD + W GDLN+R+ + YD + + +
Sbjct: 559 HMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIES-YDLHFVKFAIDS 617
Query: 119 NNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPA 178
N L L EKDQL M +N I +G+ EG + FAPT+K+ + +++Y + K+R PA
Sbjct: 618 NQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-----DTSAKKRKPA 672
Query: 179 WCDRILWKGEG----------------LNQKMY-VRGESKFSDHRPVYSLFTAQ 215
W DRILWK + + Q Y E SDH+PV + F Q
Sbjct: 673 WTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAARFLLQ 726
>P5PA_MOUSE (P59644) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56)
Length = 1003
Score = 114 bits (286), Expect = 2e-25
Identities = 71/234 (30%), Positives = 119/234 (50%), Gaps = 25/234 (10%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M G+ L ++ + + + +++ TG+ GY GNKG +S+ + + CF+ HL +
Sbjct: 501 MQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPA 560
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYD--EIHELLKN 118
++ + N +++ + + GIL+HD + W GDLN+R+ + YD + + +
Sbjct: 561 HMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIES-YDLHFVKFAIDS 619
Query: 119 NNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPA 178
N L L EKDQL M +N I +G+ EG + FAPT+K+ + +++Y + K+R PA
Sbjct: 620 NQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-----DTSAKKRKPA 674
Query: 179 WCDRILWKGEG----------------LNQKMY-VRGESKFSDHRPVYSLFTAQ 215
W DRILWK + + Q Y E SDH+PV + F Q
Sbjct: 675 WTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQ 728
>INP5_MOUSE (Q9JII1) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV)
Length = 647
Score = 114 bits (284), Expect = 3e-25
Identities = 74/243 (30%), Positives = 118/243 (48%), Gaps = 26/243 (10%)
Query: 4 IFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLASGEK 63
+++ +++R D ++ S V T I+ + KG++ +S + T+F F+ +H SG+
Sbjct: 374 LYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGD- 432
Query: 64 CGDELRRNLDIAEIIKR----------TKFSHSLGIL--EHDNIIWLGDLNYRLAAGYDE 111
G R LD + I+ + S G + D + W GD N+RL+ G
Sbjct: 433 -GKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVA 491
Query: 112 IHELLKNN---NLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTC 168
+ LK ++ ALL+ DQL E G IF G+ E I+F P+YK+ + D Y
Sbjct: 492 VEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTY----- 546
Query: 169 KSKEKRRTPAWCDRILWKGEGLNQKMYVRGES----KFSDHRPVYSLFTAQVDMTNKNLT 224
S K+RTP++ DR+L+K ++ S K SDHRPVY LF +V N+
Sbjct: 547 DSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIP 606
Query: 225 RSA 227
+A
Sbjct: 607 LAA 609
>INP5_RAT (Q9WVR1) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV) (5-phosphatase that induces
arborization) (Pharbin)
Length = 647
Score = 113 bits (283), Expect = 5e-25
Identities = 74/243 (30%), Positives = 119/243 (48%), Gaps = 26/243 (10%)
Query: 4 IFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLASGEK 63
+++ +++R D ++ S V T I+ + KG++ +S + T+F F+ +H SG+
Sbjct: 374 LYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGD- 432
Query: 64 CGDELRRNLDIAEIIKR----------TKFSHSLGIL--EHDNIIWLGDLNYRLAAGYDE 111
G R LD I+ + S G + D + W GD N+RL+ G
Sbjct: 433 -GKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVA 491
Query: 112 IHELLKNN---NLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTC 168
+ LK + ++ ALL+ DQL E G IF+G+ E I+F P+YK+ + D Y
Sbjct: 492 VEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTY----- 546
Query: 169 KSKEKRRTPAWCDRILWKGEGLNQKMYVRGES----KFSDHRPVYSLFTAQVDMTNKNLT 224
S K+RTP++ DR+L+K ++ S K SDHRPVY LF +V N+
Sbjct: 547 DSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIP 606
Query: 225 RSA 227
+A
Sbjct: 607 LAA 609
>P5PA_HUMAN (Q15735) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56)
Length = 1006
Score = 112 bits (279), Expect = 1e-24
Identities = 71/234 (30%), Positives = 120/234 (50%), Gaps = 25/234 (10%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M G+ L ++ + + + +++ TG+ GY GNKG +S+ + + CF+ HL +
Sbjct: 504 MQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPA 563
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAAGYD--EIHELLKN 118
++ + N +++ + + GIL+H+ + W GDLN+R+ + YD + + +
Sbjct: 564 HMDKAEQRKDNFQTILSLQQFQGPGAQGILDHELVFWFGDLNFRIES-YDLHFVKFAIDS 622
Query: 119 NNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPA 178
+ L L EKDQL M +N I +G+ EG + FAPT+K+ + +++Y + K+R PA
Sbjct: 623 DQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-----DTSAKKRKPA 677
Query: 179 WCDRILWK----GEG------------LNQKMY-VRGESKFSDHRPVYSLFTAQ 215
W DRILWK G G + Q Y E SDH+PV + F Q
Sbjct: 678 WTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQ 731
>INP5_HUMAN (Q9NRR6) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV)
Length = 644
Score = 109 bits (272), Expect = 9e-24
Identities = 72/243 (29%), Positives = 115/243 (46%), Gaps = 26/243 (10%)
Query: 4 IFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLASGEK 63
+++ +++R D ++ S V T I+ + KG++ IS + T+F F+ +H SG+
Sbjct: 371 LYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGD- 429
Query: 64 CGDELRRNLDIAEIIKRTKFSHSLG------------ILEHDNIIWLGDLNYRLAAGYDE 111
G R LD ++ ++ D + W GD N+RL+ G
Sbjct: 430 -GKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNFRLSGGRTV 488
Query: 112 IHELLKNN---NLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTC 168
+ LL ++ ALL+ DQL E G IF+G+ E I+F P+YK+ + D Y
Sbjct: 489 VDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTY----- 543
Query: 169 KSKEKRRTPAWCDRILWKGEGLNQKMYVRGES----KFSDHRPVYSLFTAQVDMTNKNLT 224
S K+RTP++ DR+L++ V S K SDHRPVY LF +V N+
Sbjct: 544 DSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIP 603
Query: 225 RSA 227
+A
Sbjct: 604 LAA 606
>SKIP_HUMAN (Q9BT40) Skeletal muscle and kidney enriched inositol
phosphatase (EC 3.1.3.56)
Length = 448
Score = 108 bits (269), Expect = 2e-23
Identities = 71/235 (30%), Positives = 109/235 (46%), Gaps = 24/235 (10%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M GI L V+ + + ++ L TG+ GY GNKG ++I ++LY + HL
Sbjct: 93 MQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPP 152
Query: 61 GEKCGDELRRNLDIAEIIKRTKFSHSLGILEHDNIIWLGDLNYRLAA-GYDEIHELLKNN 119
+ + D ++ + IL+HD IIW GD+N+R+ G + E +KN
Sbjct: 153 HISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNR 212
Query: 120 NLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTPAW 179
L EKDQL + + + + EG + F PTYK+ NS+ Y + EK+R PAW
Sbjct: 213 CYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDY-----DTSEKKRKPAW 267
Query: 180 CDRILWK-------------GEGLNQKMYVRGESK-----FSDHRPVYSLFTAQV 216
DRILW+ + + +RG S SDH+PV F ++
Sbjct: 268 TDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLEL 322
>SKIP_MOUSE (Q8C5L6) Skeletal muscle and kidney enriched inositol
phosphatase (EC 3.1.3.56)
Length = 468
Score = 102 bits (253), Expect = 1e-21
Identities = 69/239 (28%), Positives = 112/239 (45%), Gaps = 29/239 (12%)
Query: 1 MVGIFLCVWVRADYRNHVGNLKVSRVGTGIMGYLGNKGSISISMRLYQTTFCFVCTHLAS 60
M G+ L V+ + + ++ + TG+ GY GNKG +++ ++LY + HL
Sbjct: 111 MQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPP 170
Query: 61 GEKCGDELRRNLDIAEIIKRTKFS--HSLGILEHDNIIWLGDLNYRLA-AGYDEIHELLK 117
D+ + D I++ F IL+HD I+W GD+N+R+ G + E +
Sbjct: 171 HMYNNDQRLEHFD--RILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQESIT 228
Query: 118 NNNLKALLEKDQLRMEQNAGRIFEGWNEGSIYFAPTYKYLMNSDQYVAQTCKSKEKRRTP 177
K L EKDQL + + ++ + EG + F PTYK+ +S+ Y + EK+R P
Sbjct: 229 RKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNY-----DTSEKKRKP 283
Query: 178 AWCDRILWKGEG------------------LNQKMYVRGES-KFSDHRPVYSLFTAQVD 217
AW DRILW+ + L K YV + SDH+PV F +++
Sbjct: 284 AWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDLELN 342
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,926,514
Number of Sequences: 164201
Number of extensions: 1306426
Number of successful extensions: 3061
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2971
Number of HSP's gapped (non-prelim): 41
length of query: 280
length of database: 59,974,054
effective HSP length: 109
effective length of query: 171
effective length of database: 42,076,145
effective search space: 7195020795
effective search space used: 7195020795
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Medicago: description of AC135797.12