BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC135320.2 + phase: 0
(1662 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
SPOF_SCHPO (Q10411) Sporulation-specific protein 15 170 3e-41
CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein) 164 2e-39
GOB1_HUMAN (Q14789) Golgi autoantigen, golgin subfamily B member... 159 5e-38
C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 1... 159 6e-38
MYHB_CHICK (P10587) Myosin heavy chain, gizzard smooth muscle 159 8e-38
MLP1_YEAST (Q02455) MLP1 protein (Myosin-like protein 1) 157 3e-37
MYHB_RABIT (P35748) Myosin heavy chain, smooth muscle isoform (S... 156 5e-37
MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (S... 156 5e-37
MYS2_DICDI (P08799) Myosin II heavy chain, non muscle 154 2e-36
GCC2_HUMAN (Q8IWJ2) GRIP and coiled-coil domain-containing prote... 154 3e-36
GOA4_HUMAN (Q13439) Golgi autoantigen, golgin subfamily A member... 152 7e-36
CEP2_HUMAN (Q9BV73) Centrosomal protein 2 (Centrosomal Nek2-asso... 152 1e-35
MYHB_MOUSE (O08638) Myosin heavy chain, smooth muscle isoform (S... 150 3e-35
MYHA_HUMAN (P35580) Myosin heavy chain, nonmuscle type B (Cellul... 146 4e-34
MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular... 145 7e-34
MYHD_HUMAN (Q9UKX3) Myosin heavy chain, skeletal muscle, extraoc... 145 1e-33
MYHA_RAT (Q9JLT0) Myosin heavy chain, nonmuscle type B (Cellular... 145 1e-33
CENF_HUMAN (P49454) CENP-F kinetochore protein (Centromere prote... 143 3e-33
MYSN_DROME (Q99323) Myosin heavy chain, non-muscle (Zipper prote... 143 4e-33
CING_XENLA (Q9PTD7) Cingulin 142 6e-33
>SPOF_SCHPO (Q10411) Sporulation-specific protein 15
Length = 1957
Score = 170 bits (431), Expect = 3e-41
Identities = 313/1648 (18%), Positives = 685/1648 (40%), Gaps = 211/1648 (12%)
Query: 120 SLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENL 179
SL + S+ S R ++ E+ SN V TLR+ ++++ L QE LE
Sbjct: 237 SLAEEQASNKSLRG--EQERLEKLLVSSNKTVSTLRQTENSLRAECKTL----QEKLEKC 290
Query: 180 SKMETD---LNKAQNNARGLDDRASEAEIQVEILKESLMQ---LKADKDAGEVLYNQCLE 233
+ E D L + ++N D + +E L + + LK+++D + N+ LE
Sbjct: 291 AINEEDSKLLEELKHNVANYSDAIVHKDKLIEDLSTRISEFDNLKSERDTLSIK-NEKLE 349
Query: 234 TIARLESMLSQKDNIEAKN-LKQELTRVVVQKDTVLLQYKQCLEKIPMLE---------- 282
+ R ++ S KD+ + + L++E+ + T+ Q K+ E
Sbjct: 350 KLLR-NTIGSLKDSRTSNSQLEEEMVELKESNRTIHSQLTDAESKLSSFEQENKSLKGSI 408
Query: 283 ----NKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERD----------SLSVLYH 328
N ++ ++ + ++ Q+E + LAE+N ERD +
Sbjct: 409 DEYQNNLSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKKIKDFEKIEQDLR 468
Query: 329 HCLEK-----------ISKMENEILHVQENAEQLKNKIEKEAEKLE------ISEKHRGM 371
CL I K + E+ +++E ++ K E L+ ++EK +
Sbjct: 469 ACLNSSSNELKEKSALIDKKDQELNNLREQIKEQKKVSESTQSSLQSLQRDILNEKKKHE 528
Query: 372 LEKSNQN-----LQLEAEN------LVQRIASKDHELLEKHTEIER----LQTLMHG--- 413
+ +S N LQ E N + +A++ + + E+ LQTL +
Sbjct: 529 VYESQLNELKGELQTEISNSEHLSSQLSTLAAEKEAAVATNNELSESKNSLQTLCNAFQE 588
Query: 414 -----------EHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQD 462
NF ++++ + L + + + + + + +LK L+ L+L + +
Sbjct: 589 KLAKSVMQLKENEQNFSSLDTSFKKLNESHQELENNHQTITKQLKDTSSKLQQLQLERAN 648
Query: 463 FKEEMQGIVEENKTLHELNF---SSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVL 519
F+++ + +EN L S +SL K+Q ++ L++ + L+ + S E
Sbjct: 649 FEQKESTLSDENNDLRTKLLKLEESNKSLIKKQEDVDSLEKNIQTLKEDLRKSEEALRFS 708
Query: 520 QRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEK 579
+ E +++ I +L +++ + Q N +S+ D +N N +L K
Sbjct: 709 KLEAKNLREVIDNLKGKHETLEAQ-------RNDLHSSLSDAKNTNAILSSELTK---SS 758
Query: 580 EALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKS 639
E ++ + ++ + ++ M+ S L + + E++ +Q + + L + +S
Sbjct: 759 EDVKRLTANVETLTQDSKAMKQSFTSLVNSYQSISNLYHELRDDHVNMQSQNNTLLESES 818
Query: 640 TLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQN 699
L + + +T+ +++N L + + + L+ +G L K L N +
Sbjct: 819 KLKTDCENLTQQNMTLIDNVQKLMHKHVNQESKVSELKEVNGKLSLDLKNLRSSLNVAIS 878
Query: 700 ERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELF-------ASILV 752
+ +++QL + + +LE++ L +E +K+ + EEL + +
Sbjct: 879 DNDQILTQLAELSKNYDSLEQESAQLNSGLKSLEAEKQLLHTENEELHIRLDKLTGKLKI 938
Query: 753 QKENHSNHKHSSEARLANLENIVRV-LQEEQRLGKV--EFEQELDRVVNAQIEMFILQNC 809
++ S+ AR + N+ + + Q + V + ++ L + + ++ L+N
Sbjct: 939 EESKSSDLGKKLTARQEEISNLKEENMSQSQAITSVKSKLDETLSKSSKLEADIEHLKNK 998
Query: 810 IEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKV 869
+ E+E++ LL E+L++ K + + I+ L++E + E + L ++ + +
Sbjct: 999 VSEVEVERNALLASNERLMDDLKNNGENIASLQTEIEKKRAENDDLQSKLSVVSSEYENL 1058
Query: 870 CGVLQIDSDGGGD--NEIKKEEIPISRILD-------KIESLESSLVKSQEENQQLLVEN 920
+ + D N++K E + ++LD ++E L S K EEN Q+ E
Sbjct: 1059 LLISSQTNKSLEDKTNQLKYIEKNVQKLLDEKDQRNVELEELTSKYGKLGEENAQIKDEL 1118
Query: 921 SVL-LGSLQQHQ---SEGEKLKLEKKTVEQEFENMREQNVILQK---DKVELLEENRQLR 973
L S +QH + + LK + +EQ E V L++ + L+EE L
Sbjct: 1119 LALRKKSKKQHDLCANFVDDLKEKSDALEQLTNEKNELIVSLEQSNSNNEALVEERSDLA 1178
Query: 974 IEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKS 1033
+ + + + S + ++ ++++++ + +++ + + + +C++ DL D+
Sbjct: 1179 NRLSDMKKSLSDSDNVISVIRSDLVRVNDELDTLKKDKDSLSTQYSEVCQDRDDLLDSLK 1238
Query: 1034 SAED---ENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGV 1090
E+ + +V ++ S +++ +N V + GN S L+
Sbjct: 1239 GCEESFNKYAVSLRELCTKSEIDVPVSEILDDNFV------FNAGNFSELS--------- 1283
Query: 1091 LRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSR---HIEELKMEQEES 1147
V EN YL ++ +++ + +E+D RL T++AEF++ +E+L+ E ++
Sbjct: 1284 ---RLTVLSLEN-YL-DAFNQVNFKKMELDNRL---TTTDAEFTKVVADLEKLQHEHDDW 1335
Query: 1148 TKIKENLDRQILEQSENCMNHKKE----IEHLNEANETLQFEMKTLLHEVEQHRVREEAL 1203
+ +L++ + + +N + + E I L E E + E+ L +E +++ L
Sbjct: 1336 LIQRGDLEKALKDSEKNFLRKEAEMTENIHSLEEGKEETKKEIAELSSRLEDNQLATNKL 1395
Query: 1204 NLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAK---- 1259
+L + E +L E+ + S+ ++L ES ++ +LD ++ +
Sbjct: 1396 KNQLDHLNQEIRLKEDVLK------EKESLIISLEESLSNQRQKESSLLDAKNELEHMLD 1449
Query: 1260 --SLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGN 1317
S +N + E I + S + +L++ V + +L++ + E +SL+ S +
Sbjct: 1450 DTSRKNSSLMEKIESINSSLDDKSFELASAVEKLGALQKLHS--ESLSLM-ENIKSQLQE 1506
Query: 1318 GAQKDVVIETCLRKHSHQ--SARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVK 1375
+K V E+ +++ H+ +++ N + D S + L I + ++ EE K VK
Sbjct: 1507 AKEKIQVDESTIQELDHEITASKNNYEGKLNDKDSIIRDLSENIEQLNNLLAEE-KSAVK 1565
Query: 1376 QKSLTTESTPY---SSLEIATYPK--VENRKKEIELVEENVFDRNSWRKKPKIRLLMKDI 1430
+ S ES S L Y K VE+ +L + + + ++ L + +
Sbjct: 1566 RLSTEKESEILQFNSRLADLEYHKSQVESELGRSKLKLASTTEELQLAENERLSLTTRML 1625
Query: 1431 PLDRNVDD-QNSKYLKREHRRTNDHVLELCENNEHE-PLSAPTVDHAMICHRSDDSGRYL 1488
L V D N K E RT + + + + E + + TV+ S +
Sbjct: 1626 DLQNQVKDLSNIKDSLSEDLRTLRSLEDSVASLQKECKIKSNTVESLQDVLTSVQA---- 1681
Query: 1489 NYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLS--------SDGQKLAILKMAL 1540
++EL+ E VDK+ E +++ +L ++ Q++ L
Sbjct: 1682 -RNAELEDEVSRSVDKIRRRDDRCEHLSGKLKKLHSQLEEQHETFFRAEQQRMTQLGFLK 1740
Query: 1541 QDLKKKTETKKKSK--------QGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEG 1592
+ +KK+ + KK + + + YE+ R IE+ E V+Q+ ++++ + +G
Sbjct: 1741 ETVKKQEKLLKKLNLRQEQLIPRSSILVYESYIRDIEK-EIIVLQERLNGIELSQQLPKG 1799
Query: 1593 -------ASSLDREIPRRGSEQIGKLQF 1613
+ ++ E+ +Q+ KLQF
Sbjct: 1800 YFGYFFKTNRVEMEVLDSFKQQVAKLQF 1827
Score = 147 bits (370), Expect = 3e-34
Identities = 289/1442 (20%), Positives = 556/1442 (38%), Gaps = 210/1442 (14%)
Query: 261 VVQKDTVLLQYKQCLEKIPMLENK-----IALAEENSRMLNDQIERT---ELEVETLRKN 312
V QK +L + KQ K+ LE++ + L+ N + N T E +V +K
Sbjct: 129 VTQKSNLLNELKQVRSKLAALEHENGILSLQLSSSNKKDKNTSSVTTLTSEEDVSYFQKK 188
Query: 313 LAEMNE-------ERDSLSVLYHHCLEKISKMENEILHVQENA---------EQLKNK-I 355
L M E LS EK+ K E + ++E+ EQ NK +
Sbjct: 189 LTNMESNFSAKQSEAYDLSRQLLTVTEKLDKKEKDYEKIKEDVSSIKASLAEEQASNKSL 248
Query: 356 EKEAEKLE----ISEKHRGMLEKSNQNLQLEAENLVQR-----IASKDHELLE--KHTEI 404
E E+LE S K L ++ +L+ E + L ++ I +D +LLE KH
Sbjct: 249 RGEQERLEKLLVSSNKTVSTLRQTENSLRAECKTLQEKLEKCAINEEDSKLLEELKHNVA 308
Query: 405 ERLQTLMHGEH---------SNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD 455
++H + S F ++S L + +K RN + LKD
Sbjct: 309 NYSDAIVHKDKLIEDLSTRISEFDNLKSERDTLSIKNEKLEKLLRNT-------IGSLKD 361
Query: 456 LELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEE 515
S +EEM + E N+T+H + L + E LK ++ + + +
Sbjct: 362 SRTSNSQLEEEMVELKESNRTIHSQLTDAESKLSSFEQENKSLKGSIDEYQNNLSSKDKM 421
Query: 516 SNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKE 575
+ + + + + H + + S RD QN+ +K+ K E
Sbjct: 422 VKQVSSQLEEARSSLAHATGKLAEI---------------NSERDFQNKK--IKDFEKIE 464
Query: 576 HSEKEALREKSKDMNEVLMENACMEFSLLGLND-ELDGLRGTVKEIQQFCQVLQE----- 629
+ L S ++ E + +L+ D EL+ LR +KE ++ + Q
Sbjct: 465 QDLRACLNSSSNELKE--------KSALIDKKDQELNNLREQIKEQKKVSESTQSSLQSL 516
Query: 630 EKSILADEKSTLL--SQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCC 687
++ IL ++K + SQL + +Q + N+ L LS E E + +L +
Sbjct: 517 QRDILNEKKKHEVYESQLNELKGELQTEISNSEHLSSQLSTLAAEKEAAVATNNELSESK 576
Query: 688 KLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELF 747
L N Q + + + QL+ E+ S+L+ L E + ++E + ++ Q+++
Sbjct: 577 NSLQTLCNAFQEKLAKSVMQLKENEQNFSSLDTSFKKLNESHQELENNHQTITKQLKDT- 635
Query: 748 ASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQ 807
S+ + AN E L +E + +L ++ + + Q
Sbjct: 636 ----------SSKLQQLQLERANFEQKESTLSDENN----DLRTKLLKLEESNKSLIKKQ 681
Query: 808 NCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHR-IRKFKMDI 866
++ LE L + K EA +FS +LE++NL ++I+ H + + D+
Sbjct: 682 EDVDSLEKNIQTLKEDLRKSEEALRFS-----KLEAKNLREVIDNLKGKHETLEAQRNDL 736
Query: 867 HKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGS 926
H + +++ +E+ K + R+ +E+L K+ +++ LV + + +
Sbjct: 737 HSSLSDAK-NTNAILSSELTKSSEDVKRLTANVETLTQDS-KAMKQSFTSLVNSYQSISN 794
Query: 927 LQQH--------QSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVN 978
L QS+ L + ++ + EN+ +QN+ L + +L+ ++ VN
Sbjct: 795 LYHELRDDHVNMQSQNNTLLESESKLKTDCENLTQQNMTLIDNVQKLMHKH-------VN 847
Query: 979 GVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDE 1038
K + K L ++ LR + V +N ++L + L +N L+ +
Sbjct: 848 QESKVSELKEVNGKLSLDLKNLRSSLNVAISDNDQILTQLAELSKNYDSLEQESAQLNS- 906
Query: 1039 NSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLS---HLNNDLNQEFGVLRKNF 1095
L +L ++ TEN L + G L ++DL ++ ++
Sbjct: 907 ---------GLKSLEAEKQLLHTENEELHIRLDKLTGKLKIEESKSSDLGKKLTARQEEI 957
Query: 1096 EVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLD 1155
+ EN+ +++I + +L E + E + E+++E+ E L
Sbjct: 958 SNLKEENMSQSQAITSVKSKLDETLSKSSKLEADIEHLKNKVSEVEVERNALLASNERLM 1017
Query: 1156 RQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFK 1215
+ EN + + EIE N+ LQ ++ + E E + N L +K N+ K
Sbjct: 1018 DDLKNNGENIASLQTEIEKKRAENDDLQSKLSVVSSEYENLLLISSQTNKSLEDKTNQLK 1077
Query: 1216 LWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLES 1275
E + ++ L L SK +L EN +++ + L
Sbjct: 1078 YIEKNVQKLLDEKDQRNVELEELTSKYGKL--------------GEENAQIKDELLALRK 1123
Query: 1276 EIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQ 1335
+ K+Q V LKE ++LE ++ ++N ++ + Q + E + + S
Sbjct: 1124 K---SKKQHDLCANFVDDLKEKSDALEQLT---NEKNELIVSLEQSNSNNEALVEERSDL 1177
Query: 1336 SARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSL------ 1389
+ R ++ + +SD + + IR+ + +EL K K + ST YS +
Sbjct: 1178 ANRLSD---MKKSLSDSDNVISVIRSDLVRVNDELDTLKKDKD--SLSTQYSEVCQDRDD 1232
Query: 1390 --------------------EIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKD 1429
E+ T +++ EI L + VF+ ++ + ++ +L +
Sbjct: 1233 LLDSLKGCEESFNKYAVSLRELCTKSEIDVPVSEI-LDDNFVFNAGNFSELSRLTVLSLE 1291
Query: 1430 IPLDRNVDDQNSKYLKREHRRTN-----DHVLELCENNEHEPLSAPTVDHAMICHRSDDS 1484
LD + N K ++ ++R T V+ E +HE H + D
Sbjct: 1292 NYLDA-FNQVNFKKMELDNRLTTTDAEFTKVVADLEKLQHE--------HDDWLIQRGDL 1342
Query: 1485 GRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILE---RLSSDGQKLAILKMALQ 1541
+ L S + + KE + E S++E E+ K+ I E RL + LK L
Sbjct: 1343 EKALKDSEKNFLRKE--AEMTENIHSLEEGKEETKKEIAELSSRLEDNQLATNKLKNQLD 1400
Query: 1542 DLKKKTETKK---KSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDR 1598
L ++ K+ K K+ I E + + E +++ + + M + SSL
Sbjct: 1401 HLNQEIRLKEDVLKEKESLIISLEESLSNQRQKESSLLDAKNELEHMLDDTSRKNSSLME 1460
Query: 1599 EI 1600
+I
Sbjct: 1461 KI 1462
Score = 125 bits (315), Expect = 7e-28
Identities = 249/1136 (21%), Positives = 464/1136 (39%), Gaps = 147/1136 (12%)
Query: 145 EESNG----EVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRA 200
+E NG +++ LR +L SD D + Q E +N +E + + + + L
Sbjct: 856 KEVNGKLSLDLKNLRSSLNVAISDNDQILTQLAELSKNYDSLEQESAQLNSGLKSL---- 911
Query: 201 SEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIA--RLESMLSQKDNIEAKNLKQE-- 256
EAE Q+ + + ++ DK G++ + + +L + + N++ +N+ Q
Sbjct: 912 -EAEKQLLHTENEELHIRLDKLTGKLKIEESKSSDLGKKLTARQEEISNLKEENMSQSQA 970
Query: 257 LTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEM 316
+T V + D L + + I L+NK++ E L ER +++ +N+A +
Sbjct: 971 ITSVKSKLDETLSKSSKLEADIEHLKNKVSEVEVERNALLASNERLMDDLKNNGENIASL 1030
Query: 317 NEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGML--EK 374
E + K+S + +E ++ + Q +E + +L+ EK+ L EK
Sbjct: 1031 QTEIEKKRAENDDLQSKLSVVSSEYENLLLISSQTNKSLEDKTNQLKYIEKNVQKLLDEK 1090
Query: 375 SNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQ 434
+N++LE EL K+ ++ GE + QI+ L AL+K +
Sbjct: 1091 DQRNVELE-------------ELTSKYGKL--------GEEN--AQIKDELLALRKKSKK 1127
Query: 435 SQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQME 494
N +LK L+ L K + ++ N+ L E L +
Sbjct: 1128 QHDLCANFVDDLKEKSDALEQLTNEKNELIVSLEQSNSNNEALVEERSDLANRLSDMKKS 1187
Query: 495 ISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSF 554
+S + + + +E + L+++ + + + +L+ L+ + N +
Sbjct: 1188 LSDSDNVISVIRSDLVRVNDELDTLKKDKDSLSTQYSEVCQDRDDLLDSLKGCEESFNKY 1247
Query: 555 AASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLR 614
A S+R+L C K E ++E+L +N G EL L
Sbjct: 1248 AVSLREL----------CTKS--------EIDVPVSEILDDNFVFN---AGNFSELSRL- 1285
Query: 615 GTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFE 674
TV ++ + + + +K L ++L K++ + L + E +
Sbjct: 1286 -TVLSLENYLDAFNQ----VNFKKMELDNRLTTTDAEFTKVVAD-------LEKLQHEHD 1333
Query: 675 GLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEK 734
I+ GDLE K L D + N + + + + +EE +K++ L + D +
Sbjct: 1334 DWLIQRGDLE---KALKDSEKNFLRKEAEMTENIHSLEEGKEETKKEIAELSSRLEDNQL 1390
Query: 735 DKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRL--GKVEFEQE 792
NQ++ L I + KE+ K S L E++ Q+E L K E E
Sbjct: 1391 ATNKLKNQLDHLNQEIRL-KEDVLKEKESLIISLE--ESLSNQRQKESSLLDAKNELEHM 1447
Query: 793 LDRVVNAQIE-MFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELES-ENLMQLI 850
LD M +++ L+ K+F L + EKL K + +S +E+ ++ +Q
Sbjct: 1448 LDDTSRKNSSLMEKIESINSSLDDKSFELASAVEKLGALQKLHSESLSLMENIKSQLQEA 1507
Query: 851 EEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESL------ES 904
+E+ + ++D H++ S + ++ ++ I + + IE L E
Sbjct: 1508 KEKIQVDESTIQELD-HEITA-----SKNNYEGKLNDKDSIIRDLSENIEQLNNLLAEEK 1561
Query: 905 SLVK--SQEENQQLLVENSVLLGSLQQHQSEGE------KLKLEKKTVE-QEFENMR--- 952
S VK S E+ ++L NS L L+ H+S+ E KLKL T E Q EN R
Sbjct: 1562 SAVKRLSTEKESEILQFNS-RLADLEYHKSQVESELGRSKLKLASTTEELQLAENERLSL 1620
Query: 953 ------EQNVI--LQKDKVELLEENRQLRI--EVVNGVEKENRSKS-TLAALQAEMIELR 1001
QN + L K L E+ R LR + V ++KE + KS T+ +LQ + ++
Sbjct: 1621 TTRMLDLQNQVKDLSNIKDSLSEDLRTLRSLEDSVASLQKECKIKSNTVESLQDVLTSVQ 1680
Query: 1002 QTNQVFQEENGKMLDE---KNSLCRNVS-DLKDAKSSAEDENSVMFHDVLALSNLNLVYE 1057
N ++E + +D+ ++ C ++S LK S E+++ F + + +
Sbjct: 1681 ARNAELEDEVSRSVDKIRRRDDRCEHLSGKLKKLHSQLEEQHETFFR-----AEQQRMTQ 1735
Query: 1058 IFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELL 1117
+ F + V+K+ E L L LN L QE + R + V E+ I ++KE++
Sbjct: 1736 LGFLKETVKKQ---EKL--LKKLN--LRQEQLIPRSSILVYES-------YIRDIEKEII 1781
Query: 1118 EMDKRLKAAETS----NAEFSRHIEELKMEQEESTKIKENLDR-QILEQSENCMNHKKEI 1172
+ +RL E S F + ++E E K+ + + Q L +E + K+++
Sbjct: 1782 VLQERLNGIELSQQLPKGYFGYFFKTNRVEMEVLDSFKQQVAKLQFLAGAEFIVKFKEDL 1841
Query: 1173 EHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDL 1228
E + Q +VE EAL LN+E F+ + + YH+L
Sbjct: 1842 EKCAAEEKEKQATFDNYSEKVENLGKSIEALYF-ALNREISFRKSLALSKSAYHNL 1896
Score = 95.9 bits (237), Expect = 8e-19
Identities = 205/1066 (19%), Positives = 430/1066 (40%), Gaps = 138/1066 (12%)
Query: 637 EKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEK-N 695
+KS LL++L+ + + + N +L LS + K + L ++E +
Sbjct: 131 QKSNLLNELKQVRSKLAALEHENGILSLQLSSSNK-------KDKNTSSVTTLTSEEDVS 183
Query: 696 NLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKE 755
Q + + + S + + +L +++ + EK EKD E V + AS+ ++
Sbjct: 184 YFQKKLTNMESNFSAKQSEAYDLSRQLLTVTEKLDKKEKDYEKIKEDVSSIKASLAEEQA 243
Query: 756 NHSN---HKHSSEARLANLENIVRVLQEEQRLGKVE---FEQELDRVVNAQIEMFILQNC 809
++ + + E L + V L++ + + E +++L++ + + +L+
Sbjct: 244 SNKSLRGEQERLEKLLVSSNKTVSTLRQTENSLRAECKTLQEKLEKCAINEEDSKLLE-- 301
Query: 810 IEELELKNFVLLTECEKLVEASKFSDKVISEL-----ESENLMQLIEEEFLLHRIRKFKM 864
ELK+ V +A DK+I +L E +NL E + L + K +
Sbjct: 302 ----ELKHNVA-----NYSDAIVHKDKLIEDLSTRISEFDNLKS--ERDTLSIKNEKLEK 350
Query: 865 DIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLL 924
+ G L+ D N +EE+ + + ++ S L ++ + EN L
Sbjct: 351 LLRNTIGSLK---DSRTSNSQLEEEMV--ELKESNRTIHSQLTDAESKLSSFEQENKSLK 405
Query: 925 GSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKEN 984
GS+ ++Q+ L + K V+Q + E L +L E N + + + E
Sbjct: 406 GSIDEYQNN---LSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKKIKDFEK 462
Query: 985 RSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFH 1044
+ A L + EL++ + + +++ E N+L + + K S + +
Sbjct: 463 IEQDLRACLNSSSNELKEKSALIDKKD----QELNNLREQIKEQKKVSESTQSSLQSLQR 518
Query: 1045 DVLALSNLNLVYEIFFTENMVEKR---ALCEHLGN-LSHL----------NNDLNQEFGV 1090
D+L + VYE E E + + EHL + LS L NN+L++
Sbjct: 519 DILNEKKKHEVYESQLNELKGELQTEISNSEHLSSQLSTLAAEKEAAVATNNELSESKNS 578
Query: 1091 LR---------------------KNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETS 1129
L+ +NF + LNES + ++ + K+LK +TS
Sbjct: 579 LQTLCNAFQEKLAKSVMQLKENEQNFSSLDTSFKKLNESHQELENNHQTITKQLK--DTS 636
Query: 1130 NAEFSRHIEELKMEQEESTKIKENLDRQI----LEQSENCMNHKKEI------------E 1173
+ +E EQ+EST EN D + LE+S + K+E E
Sbjct: 637 SKLQQLQLERANFEQKESTLSDENNDLRTKLLKLEESNKSLIKKQEDVDSLEKNIQTLKE 696
Query: 1174 HLNEANETLQF---EMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQM 1230
L ++ E L+F E K L ++ + + E L + + + +N A +L
Sbjct: 697 DLRKSEEALRFSKLEAKNLREVIDNLKGKHETLEAQRNDLHSSLSDAKNTNAILSSELTK 756
Query: 1231 SSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPL 1290
SS + L + V LT K + ++ + + + L + ++ Q + +
Sbjct: 757 SSEDVKRLTANVETLTQDSKAMKQSFTSLVNSYQSISNLYHELRDDHVNMQSQNNTLLES 816
Query: 1291 VSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVS 1350
S LK D +L T++N + + QK + KH +Q ++ +E+ + +S
Sbjct: 817 ESKLKTDCENL-------TQQNMTLIDNVQK------LMHKHVNQESKVSELKEVNGKLS 863
Query: 1351 -DLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEE 1409
DL L++ + + + + + + Q L S Y SLE + ++ + K +E ++
Sbjct: 864 LDLKNLRSSLN----VAISDNDQILTQ--LAELSKNYDSLEQES-AQLNSGLKSLEAEKQ 916
Query: 1410 NVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSA 1469
+ N ++ + + + +++ S L ++ + + L E N + +
Sbjct: 917 LLHTENE-----ELHIRLDKLTGKLKIEESKSSDLGKKLTARQEEISNLKEENMSQSQAI 971
Query: 1470 PTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSD 1529
+V + D++ L+ SS+L+ + E +K+ + + R+++ L ++
Sbjct: 972 TSVKSKL-----DET---LSKSSKLEADIEHLKNKVSEVEVERNALLASNERLMDDLKNN 1023
Query: 1530 GQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNV 1589
G+ +A L+ ++ + + + + EYE + + +++ + + + KNV
Sbjct: 1024 GENIASLQTEIEKKRAENDDLQSKLSVVSSEYENLLLISSQTNKSLEDKTNQLKYIEKNV 1083
Query: 1590 EEGASSLDR---EIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNK 1632
++ D+ E+ S + GKL E I+ LL L +++ +
Sbjct: 1084 QKLLDEKDQRNVELEELTS-KYGKLGEENAQIKDELLALRKKSKKQ 1128
>CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein)
Length = 2663
Score = 164 bits (415), Expect = 2e-39
Identities = 328/1657 (19%), Positives = 691/1657 (40%), Gaps = 280/1657 (16%)
Query: 138 KKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMET------------- 184
K+ E S E+ + ++ LA++ +KD L E +ENL++M
Sbjct: 357 KQLEEVSLETRAQAME-KDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKA 415
Query: 185 -----------DLNKAQNNARG------LDDRASEAEIQVEILKESLMQLKADKDAGEVL 227
+NK +N+ + ++ + +L+E + ++ D +
Sbjct: 416 KRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESD----V 471
Query: 228 YNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIAL 287
++ L+T++ +E + K + +N++ EL + D ++L Y+Q + +E K+
Sbjct: 472 FSNTLDTLSEIEWNPATK-LLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL-- 528
Query: 288 AEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHH--------------CLEK 333
+ ND E LE +T + ++ E +L L H +E
Sbjct: 529 -----KEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHREVYNQDLENELSSKVEL 583
Query: 334 ISKMENEILHVQE-----NAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQ 388
+ + E++I +QE E +K + E +E ++ + L + + + L+A+
Sbjct: 584 LREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA-ETVALDAKRESA 642
Query: 389 RIASKDHELLEKHTEIERLQTLMHGEHSNFIQI-ESALQALQKLYSQSQKEQRNLALEL- 446
+ S++ EL EK E+ + + N IQ+ +S L+A +K+ +KE ++ E+
Sbjct: 643 FLRSENLELKEKMKEL----ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT 698
Query: 447 --------KYGLLLLKDLELSKQ--DFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEIS 496
K LL +LEL + D ++E+ VEEN+ L E + + +S
Sbjct: 699 KLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE-----------EVILLS 747
Query: 497 KLKEIK---EKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQL----QSLGL 549
+LK + E+L +E +EE +++ E ++ ++ H R Q +LE++ L
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 550 NPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDE 609
+++ ++ ++ QN + + +K E ++++ + E + SL L E
Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 610 L----DGLRGTVKEIQQFCQVLQEEKSILADEKS---TLLSQLQIITESMQKILENNTVL 662
L L+ +E+Q+ +++ K L + S T+ + +ITE +Q+ LE L
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 663 EKSLSDAKIEFEGLRIK----SGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNL 718
+ D K E L+I+ D+ D + D + L+N L E + S +
Sbjct: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI 987
Query: 719 EKKVT--------------NLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSS 764
++V+ ++K ++K ++ + L A + + K S
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 765 EARLAN-LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTE 823
+ N L+ ++ + E+ K + ++ ++ + Q E+ +L +EL+ + ++ E
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG---DELKKQQEIVAQE 1104
Query: 824 ----CEKLVEASKFSDKV--ISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDS 877
+K E S+ D++ + E E QL E++ L +++ ++ K +I+
Sbjct: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK-----KINE 1159
Query: 878 DGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKL 937
NE+K +E+ + + + L L ++ EE + + E VL + ++E + L
Sbjct: 1160 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
Query: 938 KLEKKTVE----QEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAAL 993
+ + +E Q E ++ ++ L++ + + E R + + + ++ KS L
Sbjct: 1220 RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH-TKL 1278
Query: 994 QAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLAL---- 1049
Q E+ L + ++ N K + E N +L +S+ +D ++ ++ L
Sbjct: 1279 QEEIPVLHEEQELL--PNVKKVSETQE-TMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 1050 ----------------SNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRK 1093
NL + E ++ K + E L + + Q + K
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 1094 NFE----VKEAENVYLNES-IERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQE--- 1145
+ E V E E +S + R++ E+L + KRL+ + ++ ++L+ QE
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455
Query: 1146 -ESTKIKENLDRQILEQSEN---------CMNHKKEIEHLNEANETL---QFEMKTLLHE 1192
ES ++KEN+ + + E C+ K++ E +NE L + E+ T+ +
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCL--KEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 1193 VE------QHRV-----REEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESK 1241
+E Q+++ +EE LN++ +++ E NE F + L +ESK
Sbjct: 1514 LEAINDKLQNKIQEIYEKEEQLNIKQISEVQEN---VNELKQFKEHRKAKDSALQSIESK 1570
Query: 1242 VSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSL 1301
+ ELT + +E E E M+ + L+ E LKE +V+ +KE
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK---EIVAKMKES-QEK 1626
Query: 1302 EHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRA 1361
E+ L T A + + C +H + ++ +L ++T
Sbjct: 1627 EYQFLKMT---------AVNETQEKMCEIEHLKEQFETQKL--------NLENIETENIR 1669
Query: 1362 VEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFD--RNSWRK 1419
+ +I+ E L+ + +S+T E S+E E K E + ++EN+ + K
Sbjct: 1670 LTQILHENLE---EMRSVTKERDDLRSVE-------ETLKVERDQLKENLRETITRDLEK 1719
Query: 1420 KPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICH 1479
+ +++++ + +EH+ T D + + +E +S D
Sbjct: 1720 QEELKIVHMHL---------------KEHQETIDKLRGIVSEKTNE-ISNMQKD----LE 1759
Query: 1480 RSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMA 1539
S+D+ + + +L I++EL + + L + +++T D R I +S KL+ ++
Sbjct: 1760 HSNDALK----AQDLKIQEELRIAHMHLKE--QQETIDKLRGI---VSEKTDKLSNMQKD 1810
Query: 1540 LQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDRE 1599
L++ K + K + + N+ + T+K+ + E + ++VS +Q+ K +++ + +L
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQ----KKVSEMEQLKKQIKDQSLTL--- 1863
Query: 1600 IPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNR 1636
KL+ E N+ L + EE + +K R
Sbjct: 1864 ---------SKLEIENLNLAQELHENLEEMKSVMKER 1891
Score = 162 bits (409), Expect = 9e-39
Identities = 313/1584 (19%), Positives = 670/1584 (41%), Gaps = 195/1584 (12%)
Query: 156 EALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVE---ILKE 212
E L +Q A +++ + +S E L + + L + E ++ + K+
Sbjct: 315 ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKD 374
Query: 213 SLMQLKADKDAGEVLYNQCLETIARL---ESMLSQKDNIEAKNLKQELTRVVVQKDTVLL 269
L QL +KD + + N+ +E + R+ S L+ + ++AK K+ +T
Sbjct: 375 QLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKR-KRRVT----------- 422
Query: 270 QYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHH 329
CL KI ++N A++ + N + +L + LR E++E S S ++ +
Sbjct: 423 ---WCLGKINKMKNS-NYADQFNIPTNITTKTHKLSINLLR----EIDESVCSESDVFSN 474
Query: 330 CLEKISKME----NEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAEN 385
L+ +S++E ++L+ QEN E N + + + L + + + EK L+L+ +N
Sbjct: 475 TLDTLSEIEWNPATKLLN-QENIESELNSLRADYDNL-VLDYEQLRTEKEEMELKLKEKN 532
Query: 386 ------LVQRIASKDHELLEKHTEIERLQTL----------MHGEHSNFIQI----ESAL 425
++R KD E+ H EI L+ L + E S+ +++ E +
Sbjct: 533 DLDEFEALERKTKKDQEMQLIH-EISNLKNLVKHREVYNQDLENELSSKVELLREKEDQI 591
Query: 426 QALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSST 485
+ LQ+ Y SQK + N+ ++L Y L ++D + KQ TL + +
Sbjct: 592 KKLQE-YIDSQKLE-NIKMDLSYSLESIEDPKQMKQ--------------TLFDAETVAL 635
Query: 486 RSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQ 545
+ ++ S+ E+KEK++ T + N +Q Q++ ++ Q LE+
Sbjct: 636 DAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLE-----AKKKMQVDLEKEL 690
Query: 546 SLGLNPNSFAASVRDLQNENFMLKETCKKEHSEK--EALREKSKDM--NEVLMENACMEF 601
N + S+ D + +L C E K + +E +K++ NE L E +
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLL---CNLELEGKITDLQKELNKEVEENEALREEVILLS 747
Query: 602 SLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTV 661
L L E++ LR +++ + ++ EK L E S++Q + E + K ++
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 662 LEKSLSDAKIEFEGLRIKSGDLEDCCKL-------LNDEKNNLQNERSMLISQLEIVEEK 714
+ + EF+ + D E K+ +N E NL E S L ++ +
Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 715 LS----NLEKKVTNLEEKYADVEKDKESAVN-----QVEELFASILVQKENHSNHKHSSE 765
LS L++K ++E+ ++E+ KE N Q E +++ +K + + +
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEVKT- 926
Query: 766 ARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIE-MFILQNCIEELELKNFVLLTEC 824
L ++ ++ LQE ++ + + + ++ VN I+ L+N +E L+ + T
Sbjct: 927 --LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT-- 982
Query: 825 EKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNE 884
SK S++V L E ++EF K+ G+ D D E
Sbjct: 983 ----LKSKISEEVSRNLHMEENTGETKDEFQ-----------QKMVGI-----DKKQDLE 1022
Query: 885 IKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLE-KKT 943
K + + + D + +++ Q + L+ E + L L+ +E E+LK + K+
Sbjct: 1023 AKNTQTLTADVKD------NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 944 VEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQT 1003
+E EN E ++ EL ++ + E + ++KE T L +L++
Sbjct: 1077 IEMTIENQEELRLLGD----ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
Query: 1004 NQVFQEENGKML---DEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFF 1060
+Q QE+ ++L +E + + + ++++++ K+ +++ + H + L L ++
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH--METERLELAQKL-- 1188
Query: 1061 TENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMD 1120
EN E +++ + L L E LR EA + E ++ L E
Sbjct: 1189 NENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
Query: 1121 KRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANE 1180
+ + S +E + I + ++ TK++E + +L + + + + K++ E
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI--PVLHEEQELLPNVKKVSETQETMN 1306
Query: 1181 TLQF-------EMKTLLHEVEQHRVR------EEALNLELLNKENEFKLWENEAAAFYHD 1227
L+ + T L +E R+R E ++ L KE + EA HD
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD 1366
Query: 1228 LQMSSI--CLALLESKVS--ELTGVCKILDDESSAKSLENEHMREIISLL---ESEIGGL 1280
I LA ++ S E + K D+E++ E E + S L E E+ GL
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGL 1426
Query: 1281 KEQLSAYVPLVSSLKEDFNSLEHI-SLLWTKRNSVVGN---------GAQKDVVIETCLR 1330
++L + S+ ++ + L+ + +L ++ + + N ++++ + C
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL 1486
Query: 1331 KHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIM---MEELKRRVKQKSLTTESTPYS 1387
K ++ E + L + +++ T+Q ++ A+ + ++E+ + +Q ++ S
Sbjct: 1487 KEQEETINELRVNL-SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQLNIKQISEVQE 1545
Query: 1388 SLEIATYPKVENRKKE--IELVEENVFDRNS--WRKKPKIRLLMKDIPLDRNVDDQNSKY 1443
++ K + K+ ++ +E + + + + +I++++K+ + V +
Sbjct: 1546 NVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE 1605
Query: 1444 LKREHRRTNDHVLELCENNEHE----PLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKE 1499
+ T + V ++ E+ E E ++A +C ++ + +L++E
Sbjct: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF--ETQKLNLE-N 1662
Query: 1500 LGVDKLELSKSVKEKTEDDKRRILER--LSSDGQKLAILKMALQDLKKKTETKKKSKQGN 1557
+ + + L++ + E E+ + ER L S + L + + L++ ++T T+ KQ
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE- 1721
Query: 1558 DIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQN 1617
E + V H++E +E + + I + + L+ ++ + K+Q E++
Sbjct: 1722 --ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDL-KIQEELR- 1777
Query: 1618 IQYILLKLAEENNNKVKNRISRKT 1641
I ++ LK +E +K++ +S KT
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKT 1801
Score = 160 bits (405), Expect = 3e-38
Identities = 331/1612 (20%), Positives = 669/1612 (40%), Gaps = 253/1612 (15%)
Query: 137 SKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGL 196
+K+ N E++ + LA + YQ LE KM+ DL K +A
Sbjct: 637 AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
Query: 197 DDRASEAEIQVEILKESLMQLKAD---KDAGEVLYNQCLETIARLESMLSQKDNIEAKNL 253
+ + I ++ K+ L L+ + D + L + E A E ++ E K+L
Sbjct: 697 ITKLTSL-IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS---ELKSL 752
Query: 254 KQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNL 313
E+ R+ + + + L +++ E + L ++I +T+ ++ T + N
Sbjct: 753 PSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 314 AEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLE 373
++E + L H E+ KM +L E Q + KEA+K +
Sbjct: 813 KSTDQEFQNFKTL-HMDFEQKYKM---VLEENERMNQEIVNLSKEAQK----------FD 858
Query: 374 KSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYS 433
S L+ E Q + K E+ E+ E+E+L+ + S +E + +
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQ 918
Query: 434 QSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQM 493
Q+ +E + L E L + L++ + K ++ V N E ++ SLK+ Q
Sbjct: 919 QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
Query: 494 EISKLK-EIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSL-GLNP 551
I+ LK +I E++ R H ++ T + KD+ Q + +++ Q L N
Sbjct: 979 TINTLKSKISEEVSRNLH--------MEENTGETKDEFQ----QKMVGIDKKQDLEAKNT 1026
Query: 552 NSFAASVRD------------LQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACM 599
+ A V+D L E L++ + +EKE L+ K+ E+ +EN
Sbjct: 1027 QTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ-E 1085
Query: 600 EFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENN 659
E LLG E+++ +++ +EK+ ++ L + E +K+ E +
Sbjct: 1086 ELRLLG------------DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS 1133
Query: 660 TVL---EKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKN------NLQNERSMLISQLEI 710
L ++ L + + E ++ K ++E+ L N+ KN +++ ER L +L
Sbjct: 1134 QQLQEKQQQLLNVQEEMSEMQKKINEIEN---LKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 711 VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN 770
E++ ++ K+ L+E E +++ + E+ A+ L KE E ++A+
Sbjct: 1191 NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE---------ELKIAH 1241
Query: 771 LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFI----LQNCIEELELKNFVLLTECEK 826
+ L+E Q E EL R V+ + I L+ +L+ + VL E E
Sbjct: 1242 IH-----LKEHQ-----ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 827 LVEASKFSD--KVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNE 884
L K S+ + ++ELE ++ L RI ++ +++ E
Sbjct: 1292 LPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF------------QE 1339
Query: 885 IKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEK-LKLEKKT 943
++E +++ D +++++ +L ++ ++ + E L +Q+ QS+ E+ L +++K
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET---LAKIQESQSKQEQSLNMKEKD 1396
Query: 944 VE-----QEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEM- 997
E E E + ++ L + ++E+L +++L+ E + ++ + K L LQ +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ-ESHDEMKSVAKEKDDLQRLQEVLQ 1455
Query: 998 IELRQTNQVFQEENGKMLDEKNSL----C------RNVSDLKDAKSSAEDENSVMFHDVL 1047
E Q + +E K L+ + L C +++L+ S E E S + +
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515
Query: 1048 ALSN--LNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYL 1105
A+++ N + EI+ E + + + E N+ N+L Q +++ + K++
Sbjct: 1516 AINDKLQNKIQEIYEKEEQLNIKQISEVQENV----NELKQ----FKEHRKAKDS----- 1562
Query: 1106 NESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQE----ESTKIKENLDRQILEQ 1161
+++ ++ ++LE+ RL+ ++ + EE+K QE E ++KEN + +
Sbjct: 1563 --ALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
Query: 1162 SEN-----------CMNHKK----EIEHLNEANETLQFEMKT----------LLHE-VEQ 1195
E+ +N + EIEHL E ET + ++ +LHE +E+
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 1196 HR----VREEALNLELLNKENEFKLWENEAAAFYHDL----QMSSICLALLESK--VSEL 1245
R R++ ++E K +L EN DL ++ + + L E + + +L
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 1246 TGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHIS 1305
G+ +E S + EH + + + +I +E+L LKE +++ +
Sbjct: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKI---QEELRI---AHMHLKEQQETIDKLR 1794
Query: 1306 LLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKI 1365
+ +++ + N QKD+ + Q + NE L+TL+ + +K
Sbjct: 1795 GIVSEKTDKLSN-MQKDLENSNAKLQEKIQELKANE--------HQLITLKKDVNETQKK 1845
Query: 1366 M--MEELKRRVKQKSLTTESTPYSSLEIA--------TYPKVENRKKEIELVEENVFDRN 1415
+ ME+LK+++K +SLT +L +A V + + VEE +
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEETLKLER 1905
Query: 1416 SWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHA 1475
K+ +D+ + + + + ++ L +EH+ T D + E +S T+ +
Sbjct: 1906 DQLKESLQETKARDLEIQQEL--KTARMLSKEHKETVDKL--------REKISEKTIQIS 1955
Query: 1476 MICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKE--KTEDDKRRILERLSSDGQKL 1533
DI+K+L K EL K ++E K E R+ E ++ +K+
Sbjct: 1956 -------------------DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI 1996
Query: 1534 AILKMALQDLKKKTETKKKSKQGNDIEYETVKRH--IEEVEEAVMQQVS---INDQMAKN 1588
++ LKK+ E K D T K H +EE+ ++ I + +
Sbjct: 1997 ----NEMEQLKKQFEPNYLCKCEMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2052
Query: 1589 VEEGASSLDREIPR-RGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISR 1639
++ ++L I R R + Q+ + + + Q L++ E +++K + R
Sbjct: 2053 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLMESLREKCSRIKELLKR 2104
Score = 140 bits (352), Expect = 4e-32
Identities = 381/1864 (20%), Positives = 740/1864 (39%), Gaps = 329/1864 (17%)
Query: 29 LLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDH 88
L + +++V+ +++ I + D A Y K ++ ++ ++ L ++
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY--------KSTDQEFQNFKTLHMDFEQ 831
Query: 89 AMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESN 148
+ ++ M + N + DS G+L + + T ++ R +E
Sbjct: 832 KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL-----SYKTQELQEKTREVQERL 886
Query: 149 GEVQTLREALAKMQS-------DKDALFLQYQESLEN---LSKMETDLNKAQNNAR---- 194
E++ L+E L S +K + + Q++LE L++ + DL + Q + +
Sbjct: 887 NEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
Query: 195 ----GLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESM--------- 241
+ D + E L+ +L LK ++ L ++ E ++R M
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 242 --------LSQKDNIEAKNLKQELTRVVVQKDTV--------LLQYKQCLEKIPMLENKI 285
+ +K ++EAKN Q LT V + + L+Q K L++ MLE+ I
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNT-QTLTADVKDNEIIEQQRKIFSLIQEKNELQQ--MLESVI 1063
Query: 286 ALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQ 345
A E+ L + IE T E LR E+ ++++ ++ +H ++K ++ +
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA 1123
Query: 346 ENAEQLKNKI----EKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKH 401
E E+LK K EK+ + L + E+ M +K N E ENL + +K EL +H
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN-----EIENLKNELKNK--ELTLEH 1176
Query: 402 TEIERLQTLMHGEHSNFIQIES------ALQALQKLYSQSQKEQRNLALELKY-GLLLLK 454
E ERL+ L + N+ +++S L+ LQK + + R E++ GL +
Sbjct: 1177 METERLE-LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 455 DLELSKQDFKEEMQGIVEENKTLHE--LNFSSTRSLKKQ----QMEISKLKEIKEKLER- 507
+L+++ KE + I E +++ E +T+ L+K Q EI L E +E L
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 508 -----------EFHTSTEESNVLQRET-HQIKDDIQHLNERYQAMLEQLQSLGLNPNSFA 555
E TE+S T +I+ + LNE++Q E+++SL ++
Sbjct: 1296 KKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
Query: 556 ASVRDLQNENFMLKETCKK--------EHSEKEALREKSKD---------MNEVLMENAC 598
L+ ++ LKE ++ + ++++L K KD M + +++
Sbjct: 1356 TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSA 1415
Query: 599 M---EFSLLGLNDEL----DGLRGTVKE---IQQFCQVLQEEKSILADEKSTLLSQLQII 648
+ E +LGL+ L D ++ KE +Q+ +VLQ E L + ++++ +
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAK-HLE 1474
Query: 649 TESMQKIL--------ENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNE 700
TE K+ E L +LS+ + E ++ + + D KL N + + E
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND--KLQNKIQEIYEKE 1532
Query: 701 RSMLISQLEIVEEKLSNLEKKVTNLEEKYA---DVEKDKESAVNQVEELFASILVQKENH 757
+ I Q+ V+E ++ L++ + + K + +E N+++E I + +
Sbjct: 1533 EQLNIKQISEVQENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 758 SNHKHSSEARLA-------NLENIVRVLQEEQ-------RLGKVEFEQELDRVVNAQIEM 803
K EA N + IV ++E Q ++ V QE + E
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 804 FILQNC-IEELELKNF----VLLTECEKLVEASKFSDKVISELES---------ENLMQL 849
F Q +E +E +N +L E++ +K D + S E+ ENL +
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 850 I-------EEEFLLH-RIRKFKMDIHKVCGV----------LQIDSDGGGD----NEIK- 886
I EE ++H +++ + I K+ G+ +Q D + D ++K
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
Query: 887 KEEIPISRI--------LDKI---------------ESLESSLVKSQEENQQLLVENSVL 923
+EE+ I+ + +DK+ + LE+S K QE+ Q+L L
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
Query: 924 L------GSLQQHQSEGEKLK--------------LEKKTVEQEF-ENMRE-QNVILQKD 961
+ Q+ SE E+LK +E + QE EN+ E ++V+ ++D
Sbjct: 1833 ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERD 1892
Query: 962 KVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSL 1021
+ +EE L++E E +K+ +Q E+ R ++ +E K+ ++ +
Sbjct: 1893 NLRRVEET--LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 1022 CRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLN 1081
+SD++ ++DE + L L L+ + NM K+
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQE-LQKKELQLL-RVKEDVNMSHKKI------------ 1996
Query: 1082 NDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELK 1141
N++ Q L+K FE ++ ++ K+L E + ++ E R E LK
Sbjct: 1997 NEMEQ----LKKQFEPNYLCKCEMDNF--QLTKKLHESLEEIRIVAKERDELRRIKESLK 2050
Query: 1142 MEQEE-STKIKENLDRQILEQSENCMNHKKEI----EHLNEANETLQFEMKTLLHEVEQH 1196
ME+++ ++E + R Q+ K+ + +HL E+ +K LL +
Sbjct: 2051 MERDQFIATLREMIARD--RQNHQVKPEKRLLSDGQQHLMESLREKCSRIKELLKRYSEM 2108
Query: 1197 RVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVC------K 1250
E LN L+ E E + +H + + +K+ E C
Sbjct: 2109 DDHYECLNRLSLDLEKEIE---------FHRIMKKLKYVLSYVTKIKEEQHECINKFEMD 2159
Query: 1251 ILDDESSAKSL--ENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLW 1308
+D+ K L + +H+++ + E+ LK + + + LK DF+ E S+
Sbjct: 2160 FIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK-DFSESEFPSIK- 2217
Query: 1309 TKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMME 1368
T+ V+ N + +E L +N I D RI V
Sbjct: 2218 TEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND----------RICQVNNFFNN 2267
Query: 1369 ELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMK 1428
+ ++ EST + + E K ++ E +F +N K + +
Sbjct: 2268 RI------IAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF-KNYQTLKTSLASGAQ 2320
Query: 1429 DIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYL 1488
P + D++N R + T + + EL EN+ HE + AM H+ + +
Sbjct: 2321 VNPTTQ--DNKNPHVTSRATQLTTEKIREL-ENSLHE-----AKESAM--HK---ESKII 2367
Query: 1489 NYSSELDIEKELGVD---KLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKK 1545
EL++ ++ K+ S EKT++ + + ++++ + K ++DLK
Sbjct: 2368 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKP---YKEEIEDLKM 2424
Query: 1546 KTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREI----- 1600
K K N E+E + I + V Q + + +N+ + D +
Sbjct: 2425 KLVKIDLEKMKNAKEFE---KEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHT 2481
Query: 1601 ---PRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISRKTGILLRRKLRVCGCSGP 1657
P G VQN + ++LK K +++ ++ L+++K + +
Sbjct: 2482 DPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH 2541
Query: 1658 STNE 1661
+NE
Sbjct: 2542 LSNE 2545
Score = 126 bits (316), Expect = 6e-28
Identities = 260/1318 (19%), Positives = 542/1318 (40%), Gaps = 188/1318 (14%)
Query: 126 ESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETD 185
+S T AR + +ES E+++L + +++ K+AL +++ + E++ +
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 186 LNKAQN------NARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLE 239
+ ++Q+ N + D+ ++ ++E K L + L + E+ ++
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438
Query: 240 SMLSQKDNIE--AKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLND 297
S+ +KD+++ + L+ E ++ ++ ++ + E++ + + EE L
Sbjct: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498
Query: 298 QIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKME-NEILHVQENAEQLK---- 352
+ E E+ T++K L +N D L EK ++ +I VQEN +LK
Sbjct: 1499 NLSEKETEISTIQKQLEAIN---DKLQNKIQEIYEKEEQLNIKQISEVQENVNELKQFKE 1555
Query: 353 --------------------NKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENL------ 386
N++++ E+++I K + +++ + LQ+E + L
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 387 ----VQRIASKDHELL---------EKHTEIERLQTLMHGEHSNFIQIESALQALQKLYS 433
++ K+++ L EK EIE L+ + N IE+ L ++
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
Query: 434 QSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQM 493
++ +E R++ E + + L++ + KE ++ + + E LK+ Q
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Query: 494 EISKLKEIKEKLEREFHTSTEE----SNVLQRETHQIKDDIQ----HLNERYQAMLEQLQ 545
I KL+ I + E ++ ++ L+ + +I+++++ HL E+ + + +
Sbjct: 1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG 1795
Query: 546 SLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLG 605
+ + + +DL+N N L+E ++ + + L KD+NE + + ME
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 606 LNDELDGLRGTVKE----IQQFCQVLQEEKSILADE------KSTLLSQLQIITESMQKI 655
+ D+ L E Q+ + L+E KS++ + + TL + + ES+Q+
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 656 LENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLE-IVEEK 714
+ +++ L A++ L K D+ +E+++ IS ++ +++
Sbjct: 1916 KARDLEIQQELKTARM-----------LSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964
Query: 715 LSNLEKKVTNLEEKYADVEKDKESA------VNQVEEL---FASILVQKENHSNHKHSSE 765
L+KK+ L++K + + KE +N++E+L F + K N + + +
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEMDNFQLTKK 2024
Query: 766 ARLANLENIVRVLQEEQRLGKVE--FEQELDRVVNAQIEMFILQNCIEELELKNFV---- 819
+LE I V +E L +++ + E D+ + EM +++ + +
Sbjct: 2025 LH-ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2083
Query: 820 -------LLTECEKLVEASKFSDKVISELESENLMQL-IEEEFLLHRI-RKFKMDIHKVC 870
L +C ++ E K ++ E N + L +E+E HRI +K K + V
Sbjct: 2084 QQHLMESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHRIMKKLKYVLSYVT 2143
Query: 871 GVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQH 930
+ + + I K E+ +D++E + L+K Q Q V + L
Sbjct: 2144 KIKEEQHEC-----INKFEMD---FIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ 2195
Query: 931 QSEGEKLKLEKKTVEQEFENMR---EQNVILQKDKVELLEE--NRQLRIE-VVNGVEKEN 984
+ ++ K E EF +++ +Q + +K+ + LEE N + IE + NG++KEN
Sbjct: 2196 NMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN 2255
Query: 985 RS--------KSTLAALQAEMIELRQTNQVFQ---EENGKMLDEKN-SLCRNVSDLKDAK 1032
+ + A+ E E + + E++ K L EKN L +N LK +
Sbjct: 2256 DRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL 2315
Query: 1033 SSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQ--EFGV 1090
+S N N N T+ EK + L N L++ E +
Sbjct: 2316 ASGAQVNPT------TQDNKNPHVTSRATQLTTEK---------IRELENSLHEAKESAM 2360
Query: 1091 LRKNFEVK-EAENVYLNESIERMDKELLEMDKRL-KAAETSNAEFSRHIEELKMEQEEST 1148
+++ +K + E N+ I ++ ++ E +K L K ET + K +EE
Sbjct: 2361 HKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE 2420
Query: 1149 KIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELL 1208
+K L + LE+ +N +KEI + T++++ + + E R ++A + ++
Sbjct: 2421 DLKMKLVKIDLEKMKNAKEFEKEI---SATKATVEYQKEVIRLLRENLRRSQQAQDTSVI 2477
Query: 1209 NKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMRE 1268
++ + D Q S+ L G + + A L++EH+R
Sbjct: 2478 SE--------------HTDPQPSNKPLT---------CGGGSGIVQNTKALILKSEHIR- 2513
Query: 1269 IISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIE 1326
LE EI LK+Q + + L + L + W +R + A K V E
Sbjct: 2514 ----LEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER--TLKREAHKQVTCE 2565
Score = 102 bits (255), Expect = 7e-21
Identities = 218/1017 (21%), Positives = 418/1017 (40%), Gaps = 102/1017 (10%)
Query: 42 SMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMP 101
S ++ IE + R + ++ ++K EE R AL D + M
Sbjct: 1562 SALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK 1621
Query: 102 EAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEV-QTLREALAK 160
E+ Y L + + E K N + E N + Q L E L +
Sbjct: 1622 ES-QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 161 MQS---DKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQL 217
M+S ++D L S+E K+E D + + N R R E + +++I+ L +
Sbjct: 1681 MRSVTKERDDL-----RSVEETLKVERD--QLKENLRETITRDLEKQEELKIVHMHLKEH 1733
Query: 218 KADKDAGEVLYNQCLETIARLESMLSQK-DNIEAKNLK-QELTRVV-----VQKDTVLLQ 270
+ D + ++ I+ ++ L D ++A++LK QE R+ Q++T+
Sbjct: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
Query: 271 YKQCLEKIPMLENKIALAEENSRMLNDQIER---TELEVETLRKNLAEMNEERDSLSVLY 327
EK L N E ++ L ++I+ E ++ TL+K++ E ++ + L
Sbjct: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
Query: 328 HHCLEK---ISKMENEILHV----QENAEQLKNKIEK--------EAEKLEISEKHRGML 372
++ +SK+E E L++ EN E++K+ +++ E KLE + +
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 373 EKSNQNLQLEAENLVQRIASKDH-ELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKL 431
E ++L+++ E R+ SK+H E ++K E +T+ + ++ + LQK
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK--DLDKSKDELQKK 1971
Query: 432 YSQSQKEQRNLALELKYGLLL----LKDLELSKQDF------KEEMQGIVEENKTLHELN 481
+ QK++ L L +K + + + ++E K+ F K EM + K LHE +
Sbjct: 1972 IQELQKKELQL-LRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEMDNF-QLTKKLHE-S 2028
Query: 482 FSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAML 541
R + K++ E+ ++KE + +F + E R+ HQ+K + + L++ Q ++
Sbjct: 2029 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLM 2088
Query: 542 EQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM------- 594
E L+ ++ + L E E R K + VL
Sbjct: 2089 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHRIMKK-LKYVLSYVTKIKE 2147
Query: 595 -ENACMEFSLLGLNDELDGLRGT---VKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
++ C+ + DE++ + ++ +QQ C V E L ++ L +I+ +
Sbjct: 2148 EQHECINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2207
Query: 651 -SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLE 709
S + T ++ LS+ K + L D KL KN +Q E +
Sbjct: 2208 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKL----KNGIQKENDRICQVNN 2263
Query: 710 IVEEKLSNLEKKVTNLEEKYADV----EKDKESAVNQVEELFASILVQK----------- 754
++ + + T EE+ A + E+D +S + E+LF + K
Sbjct: 2264 FFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP 2323
Query: 755 --ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEE 812
+++ N +S A E I R L+ K + +++ Q E+ + + I +
Sbjct: 2324 TTQDNKNPHVTSRATQLTTEKI-RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAK 2382
Query: 813 LELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGV 872
L+ K + E K +E +K + +V+ + + EE L +++ K+D+ K+
Sbjct: 2383 LQAK----VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL-KMKLVKIDLEKMKNA 2437
Query: 873 LQIDSDGGGDN---EIKKEEIPISRI-LDKIESLESSLVKSQEENQQLLVENSVLL---G 925
+ + + E +KE I + R L + + + + V S+ + Q N L G
Sbjct: 2438 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQ--PSNKPLTCGGG 2495
Query: 926 SLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEK 982
S ++ LK E +E+E +++QN L K K ELL N+ L EV E+
Sbjct: 2496 SGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER 2552
>GOB1_HUMAN (Q14789) Golgi autoantigen, golgin subfamily B member 1
(Giantin) (Macrogolgin) (Golgi complex-associated
protein, 372-kDa) (GCP372)
Length = 3259
Score = 159 bits (403), Expect = 5e-38
Identities = 316/1598 (19%), Positives = 649/1598 (39%), Gaps = 218/1598 (13%)
Query: 146 ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEI 205
E ++ L++ ++K + D L Q E L+K++T++ + ++ + L ++ E+
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH---TQLEM 1445
Query: 206 QVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNI-EAKNLKQELTRVVVQK 264
Q + E + QL+ + L M + + I E KQ++ R +
Sbjct: 1446 QAKEHDERIKQLQVE-----------------LCEMKQKPEEIGEESRAKQQIQRKL--- 1485
Query: 265 DTVLLQYKQCLEKIPMLENKIALA----EENSRMLND---QIERTELEVETLRKNLAEMN 317
L+ K+ L++ L+ +++LA E ++ L D Q+ E +T+ LA +
Sbjct: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
Query: 318 EERDSL------SVLYHHCLEK-ISKMENEILHVQENAEQLKNKIE-----KEAEKLEIS 365
EERD L S+L + L ++ + + E+ E+L +IE K AE E
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605
Query: 366 EKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESAL 425
EKH+ L+K + L EN+ H + E + L + +N + E L
Sbjct: 1606 EKHKE-LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL 1664
Query: 426 QALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSST 485
Q ++ + +++ R A + +L +LE + E+ + K E SS
Sbjct: 1665 QEAEQEMEEMKEKMRKFAKSKQQKIL---ELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 486 RSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQ 545
S+K+ E+ ++K E L ++F + E + L E +K I+ N QA LE +
Sbjct: 1722 ASMKE---ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIED-NVSKQANLEATE 1777
Query: 546 SLGLNPNSFAASVRDLQNE-------NFMLKETCKKE-HSEKEALREKSKDMNEVLMENA 597
N + + E + + TC + S K A SKD + N
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
Query: 598 CMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILE 657
++ + L + + GL ++ ++F Q L+ EK+ L + ST +L+++ E + K+
Sbjct: 1838 YLQ-QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNL 1896
Query: 658 NNTVLEKSLSDAKIEFEGLRIKSGDLED-----CCKLLNDEKNNLQNERSMLISQLEIVE 712
N +++ LS E + DLE+ +L N Q+ I E++E
Sbjct: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN-ELLE 1955
Query: 713 EKLSNLEKKVTNLEEKYADVEKDKESAVNQV-EELFASILVQKENHSNHKHSSEA----- 766
++ NL+K V+ LEE+ + K+K +++ +E I ++ N H+ E
Sbjct: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
Query: 767 ------------------RLANLENIVRVL-------QEEQRLGKVEFEQELDRVVNAQI 801
+++ LE V+ L Q++ + K Q ++ AQ
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQA 2075
Query: 802 EMFILQNCIEELELKNFVLLTECEKL---VEASKFSDKVISELESENL---MQLIEEEFL 855
E+ + +++ + + +L + KL ++++K S K + + E+L ++ EE+ L
Sbjct: 2076 ELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135
Query: 856 ---------LHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSL 906
L +R+ K+ + + G +Q+ + D E+++ + + + ++ + S+
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK-DKEVQQLQENLDSTVTQLAAFTKSM 2194
Query: 907 VKSQEENQQLLVENSVLLGSLQQH-QSEGEKLKLEKKTVEQEFENMREQNVILQKDKVEL 965
Q++ +++ E QS+ E+++L++ + +R+ ++ +++ K+ +
Sbjct: 2195 SSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINI 2254
Query: 966 --LEENRQL-RIEVVNGVEKENRSKSTLAALQAEMI-ELRQTNQVF---QEENGKMLDEK 1018
LE ++Q+ + V+ + + TL E++ +L +T ++ Q E K+ E
Sbjct: 2255 SRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL 2314
Query: 1019 NSLCRNVSDLKDAKSSAEDENS----VMFHDVLALSNLNLVYEIFFTENMVEKRALCEHL 1074
SL ++DL ++ +++ ++ + N YE T+ +
Sbjct: 2315 KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT---- 2370
Query: 1075 GNLSHLNNDLN-QEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEF 1133
S L+ ++N +E ++ +EA V + E ++ DKE+ E++ L E N
Sbjct: 2371 ---SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVL 2427
Query: 1134 SRH-----------IEELKMEQEESTKIKENLDRQILEQSENCMNHKKEI----EHLNEA 1178
+E LK ++E+ + K LD + S + N + I + L E
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS-SLQNDRDRIVGDYQQLEER 2486
Query: 1179 NETLQFEMKTLLHEV--EQHRVREEALNLEL----LNKEN--------EFKLWENEAAAF 1224
+ ++ E L+ E E ++++EE L LN EN +++ N+
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546
Query: 1225 YHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
Q + + L ++K EL L+++ NE +R + L+ E L +++
Sbjct: 2547 KDSQQKQLLEVQLQQNK--ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI 2604
Query: 1285 SAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVL 1344
+ +S L +L+ L AQ V E R + S+ + I
Sbjct: 2605 ESLKVSISQLTRQVTALQEEGTLGLYH-------AQLKVKEEEVHRLSALFSSSQKRIAE 2657
Query: 1345 IPDGVSDLLTLQT----RIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPK--VE 1398
+ + +L+ +Q ++ +E + +ELK + T + +A + VE
Sbjct: 2658 LEE---ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 1399 NRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLEL 1458
+K + + +EN + + M + R+ ++ LKR++ + + +L
Sbjct: 2715 MEQKLLMVTKEN---KGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQL 2771
Query: 1459 CE----NNEHEPLSAPTV------DHAMICHRS-------DDSGRYLNYSSELD------ 1495
E N E + L + T + + H + L+ SS+L+
Sbjct: 2772 KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQV 2831
Query: 1496 ---------IEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKK 1546
++ E EL K K+E+ K+R + S+ ++ LK A+ L+
Sbjct: 2832 QSFSKAMASLQNERDHLWNELEKF--RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
Query: 1547 TETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQ 1584
+ K + +Y + + I E+ Q D+
Sbjct: 2890 RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDK 2927
Score = 153 bits (386), Expect = 4e-36
Identities = 348/1777 (19%), Positives = 707/1777 (39%), Gaps = 230/1777 (12%)
Query: 4 LSESESRRLYSWWWDSHNSPKNSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYK 63
LSE+E + D N + K + +I+ +K I E E + E
Sbjct: 1029 LSETERGEVEE---DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 64 KRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGP 123
+ LV++ + + + D E+ + + ++ D S S+
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT-----DASDGDSVAL 1140
Query: 124 DAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKME 183
E+ + P S ++ + L E + ++ +K+ L + QE+L + +
Sbjct: 1141 VKETVVISPPCTGSSEHWKPE---------LEEKILALEKEKEQLQKKLQEALTSRKAI- 1190
Query: 184 TDLNKAQNNARGLDDRASEAEIQVEILKESL-MQLKADKDAGEVLYNQCLETIARLESML 242
L KAQ R L + + + L+E Q K +++ G+ L ++ ++ L
Sbjct: 1191 --LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL 1248
Query: 243 SQKDNIEA----KNLKQELTRVVVQKDTV-LLQYKQC------LEKIPMLENKIALAEEN 291
D E+ L++ L + Q T +L+ C E L+ ++A+
Sbjct: 1249 PSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIK 1308
Query: 292 SRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQL 351
+++ + E+ ELE++ + +E+ ++ + + L E+I+K EI ++ + +
Sbjct: 1309 AQLKEIEAEKVELELK-VSSTTSELTKKSEEVFQLQ----EQINKQGLEIESLKTVSHEA 1363
Query: 352 KNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLM 411
+ E +KLE S+ LE + LQ + + L + I+ K+ ++ ++ + +
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRE-LQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 412 HGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLK-------DLELSKQDFK 464
+ I+ E ++AL KE +L+ L +K + +KQ +
Sbjct: 1423 TKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQ 1482
Query: 465 EEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETH 524
++Q + K + N S L + I +L + +E + +E + +
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 525 QIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEA--- 581
++++ L L + QSL + S ++ L + L + + S K A
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 582 -LREKSKDMN---EVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADE 637
+EK K++ E+L++ S +++E + ++ V+ ++Q Q L +
Sbjct: 1603 EWQEKHKELQKEYEILLQ------SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 638 KSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEG----LRIK---SGDL-EDCCKL 689
K QLQ + M+++ E KS +E E LR + +GD ++C +
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 690 LNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFAS 749
L +++ E + + E + +K +L + +L E+ D++ E V++ L A+
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEAT 1776
Query: 750 ILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQ-IEMFILQN 808
E H N + +E ++I +E+ L + V +A+ + ++
Sbjct: 1777 -----EKHDNQTNVTEE---GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828
Query: 809 CIEELELKNFVL----LTECEKLVEASKFSDKVISE-LESENLMQLIEEEFLLHRIRKFK 863
E+ N++ L E +E K +K S+ LE+E L + ++ +
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 864 MDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVL 923
++ K+ + Q +I++E +SR+ E+ E +E L E +
Sbjct: 1889 EEVTKMNLLNQ---------QIQEE---LSRVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
Query: 924 LGSLQQH----QSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNG 979
+G+ Q Q + E L+ E K +++ + E+ L K+K ++ E R+ +E + G
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 980 VEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDL--------KDA 1031
+KE +KS LQ + E +Q + Q++ + ++ ++L R V L KD
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL 2056
Query: 1032 KSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHL-------GNLSHLNNDL 1084
+ + E+ + H A + L + R L ++L N + + +
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 1085 NQEFGVLRKNFEVKE------------------AENVYLNESI-------ERMDKELLEM 1119
Q+ L + E E E V+L E+I + DKE+ ++
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 1120 DKRLKAAETSNAEFS-----------RHIEELKMEQEESTKIKENLDRQILEQSENCMNH 1168
+ L + T A F+ R I+E K + + + ++ + +I + +NC
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 1169 KKEIEHLNEANETLQFEMKTLLHEVE------QHRVREEALNLELLNKENEFKLWE-NEA 1221
K ++ ++ E L+ + L H+ + Q V+ + + L EN+ L + E
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 1222 AAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGG-- 1279
YH Q LA LES++ L L + + ++ II E++I
Sbjct: 2297 RHLYHSSQNE---LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSK 2353
Query: 1280 -----LKEQLSAYVPLVSSLKEDFNSLEH--ISLLWTKRNSVVGNGAQKDVVIETCLRKH 1332
L+ L A L S L E+ N E ISLL K ++ A+ LR+
Sbjct: 2354 FSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE--------LRQQ 2405
Query: 1333 SHQSARENEIVLIPDGVSDLLTLQTRIRAVEKI--MMEELKRRVKQKSLTTESTPYSSLE 1390
+ +E E +L + +++ + +AV+K +ME LK +K++++ ++ S
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK-TIKKENIQQKAQLDSF-- 2462
Query: 1391 IATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRR 1450
+ + ++N + I V D ++ +L KD + + N LK E R
Sbjct: 2463 VKSMSSLQNDRDRI------VGDYQQLEERHLSIILEKDQLIQEAAAENNK--LKEEIRG 2514
Query: 1451 TNDHVLELCENNEHEPLSAPTVDH-----AMICHRSDDSGRYLNYSSELDIEKELGVDKL 1505
H+ +L N+E+ L A + + +I + + L + + E E KL
Sbjct: 2515 LRSHMDDL--NSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 1506 ELSKSVKEKTEDDKRRILERLSSDGQKLA----ILKMALQDLKKK--------------T 1547
E E+ +D RR L + Q L+ LK+++ L ++
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 1548 ETKKKSKQGNDIE--YETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREI----- 1600
+ K K ++ + + + + ++ I E+EE + V + + AK V E L +E+
Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKRIAELEE---ELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 1601 --------PRRGSEQIGKLQFEVQNIQYILLKLAEEN 1629
E++ +L ++ ++ LL + +EN
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKEN 2726
Score = 139 bits (351), Expect = 5e-32
Identities = 327/1689 (19%), Positives = 691/1689 (40%), Gaps = 248/1689 (14%)
Query: 83 AERYDHAMGELRHAHKTMPEAF-PNSAYYILNDDSPCGSLGPDAESHT------SARPTH 135
AE DH + + + + E P L D L P+ ES A H
Sbjct: 585 AEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 136 RSKKNERSSEESNG-EVQTLREALAKMQSDKDALFLQYQESLENLS----KMETDLNKAQ 190
+S+ +E S G E+++ ++ K S + +Q+ LE L ++E + +KAQ
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704
Query: 191 N-NARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIE 249
+ LD++A E + L + + + K + D + E + +LSQ ++
Sbjct: 705 EIYEKNLDEKAKE----ISNLNQLIEEFKKNADNNSSAFTALSE---ERDQLLSQ---VK 754
Query: 250 AKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELE---- 305
++ EL V Q + L + E+ L+ + A +N +L +QI +E
Sbjct: 755 ELSMVTELRAQVKQLEMNLAE----AERQRRLDYESQTAHDN--LLTEQIHSLSIEAKSK 808
Query: 306 ---VETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAE-- 360
+E L+ L ++ + S L ++ E+E+L E + +K+E+ ++
Sbjct: 809 DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL 868
Query: 361 ---KLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLE-KHTEIERLQTLMHGEHS 416
+LEI++ + +LEK + E L Q I KD ++ E + E++ L + S
Sbjct: 869 SQKELEITKMDQLLLEKKR-----DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Query: 417 NFIQIESALQALQKL--YSQSQKEQRNLALELKYGLLLLKDL-----ELSKQDFKEEMQG 469
++I++ + L L +++KEQ E+ GL D ++SK++ + E
Sbjct: 924 LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983
Query: 470 IVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDD 529
+ +EN+ ++ + K+ +S+L+E L+ E S +E + + E ++++D
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE---SKKEIPLSETERGEVEED 1040
Query: 530 IQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDM 589
++ + + + Q + + ++ + + E +++ +++ + +E + K M
Sbjct: 1041 KENKEYSEKCVTSKCQEIEI---YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097
Query: 590 NEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQII- 648
N+ L + +++D L+ + E Q Q L + +D S L + ++
Sbjct: 1098 NQTLQDK----------TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147
Query: 649 ------------TESMQKIL-------ENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKL 689
E +KIL + L+++L+ K + + K L + K
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 690 LNDEKNNLQNERSMLISQLEIVEEKLSNLEKKV-TNLEEKYADVEKDKESAVNQVEELFA 748
D+ N LQ + + E + ++L L+ +V +++ K D++ + + L
Sbjct: 1208 QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPST--DQQESCSSTPGLEE 1265
Query: 749 SILVQKENHSNH------------KHSSEARLANLENIVRVLQEEQRLGKVEFEQ-ELDR 795
+ E H HS +A + L+ V Q + +L ++E E+ EL+
Sbjct: 1266 PLFKATEQHHTQPVLESNLCPDWPSHSEDA--SALQGGTSVAQIKAQLKEIEAEKVELEL 1323
Query: 796 VVNAQI--------EMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLM 847
V++ E+F LQ I + L E E L S +E+ +E+L
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGL-------EIESLKTVSH-----EAEVHAESLQ 1371
Query: 848 QLIEEEFL----LHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLE 903
Q +E L L +R+ + + ++ I K+E +S + ++ E
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDEL------------QKLISKKEEDVSYLSGQLSEKE 1419
Query: 904 SSLVKSQEE--NQQLLVE--NSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQ 959
++L K Q E Q+ L++ ++ L ++H ++L++E ++Q+ E + E++ Q
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 960 K----------DKVELLEENRQLRIEVV---NGVEKENRS----KSTLAALQAEMIELRQ 1002
+ + E L+EN+ L+ E+ +E+ +S +S ++A E +
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLG 1539
Query: 1003 TNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTE 1062
+ QEE K++ E + R++ + + SS E LAL L E E
Sbjct: 1540 RLALLQEERDKLITEMD---RSLLENQSLSSSCESLK-------LALEGLTEDKEKLVKE 1589
Query: 1063 NMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKR 1122
K + + +L +E+ +L +++E E + +E + +E E+ +
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 1123 LKAAETSNAEFSRHIEELKMEQEE----STKIKENLDRQILEQSENCMNHKKEI----EH 1174
L++ E + E + ++E + E EE K ++ ++ILE E + E+ +
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 1175 LNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSIC 1234
E ETL ++ E+E+ ++ E L+ + + +E E H ++ +
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSK 1769
Query: 1235 LALLES--KVSELTGVCK--------ILDDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
A LE+ K T V + +++ S E + +S + +
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829
Query: 1285 SA------YVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSAR 1338
S+ Y+ + LKE LE + + + N +K+ ++ K
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN--EKNTLLSQISTKDGELKML 1887
Query: 1339 ENEIV---LIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYP 1395
+ E+ L+ + + L+ T+++ + ++L+ R+ + + + + T
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA 1947
Query: 1396 KVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRR--TND 1453
+++N E E+ +N+ S ++ K +L+ + ++ + + + ++ +
Sbjct: 1948 QIKNELLESEM--KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKS 2005
Query: 1454 HVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSS----ELDIEKELGVDKLELSK 1509
H EL E + + + I ++ S + + + +K+L + K L++
Sbjct: 2006 HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ 2065
Query: 1510 SVKEKTE------------DDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGN 1557
+V+ + + DD + R+ +D K LK LQ K+ +++ K K
Sbjct: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK---LKKELQSNKESVKSQMKQKD-- 2120
Query: 1558 DIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQF---- 1613
E ++R +E+ EE +++ KN++E +L RE E IG++Q
Sbjct: 2121 ----EDLERRLEQAEEKHLKE-------KKNMQEKLDALRREKVHL-EETIGEIQVTLNK 2168
Query: 1614 ---EVQNIQ 1619
EVQ +Q
Sbjct: 2169 KDKEVQQLQ 2177
Score = 124 bits (311), Expect = 2e-27
Identities = 341/1760 (19%), Positives = 720/1760 (40%), Gaps = 226/1760 (12%)
Query: 20 HNSPKNSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAY 79
HN+ +N+ ++T+ + L+E+ A R ++ + E+ L+E+F +A
Sbjct: 303 HNTLRNT---------VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 80 RALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKK 139
+A AE + L HK E +IL+ G + +S A SK
Sbjct: 354 QAQAE-LESRYSALEQKHKAEME---EKTSHILS----LQKTGQELQSACDALKDQNSKL 405
Query: 140 NERSSEESNGEVQTLREALAKMQ--SDKDALFLQYQESLENLSKMETDLNKAQNNARGLD 197
+ +E++ QT+++ ++Q S + + FL ++ + +T N +
Sbjct: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN-----E 460
Query: 198 DRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQEL 257
+ E + L++ +++L+ +K A + + E A E + SQ +EA+N E
Sbjct: 461 GTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEA 520
Query: 258 TRVVVQKDTVLLQYKQCLEK----IPMLENKIALAEENSRMLNDQIERTELEVETLRKNL 313
R V + V + K+ +LEN + + +L +++ + E+ L+ L
Sbjct: 521 DREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
Query: 314 AEMNEERDSLSVLYHHCLEKISKMENEIL----------------HVQENAEQLKNKIEK 357
E VL +++ +ME E + + N E +EK
Sbjct: 581 QGKRAEEADHEVLDQ---KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637
Query: 358 EAEKLEISEKHRGMLEKSNQNLQLEA-ENLVQRIASKDHELLEKH-TEIERLQTLMHGEH 415
E E + + ++ ++L++ + + S ++ + H E+ERL+
Sbjct: 638 EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK------- 690
Query: 416 SNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENK 475
S +++E Q++Y ++ E+ A E+ L+++ + + + + EE
Sbjct: 691 SQILELELNFHKAQEIYEKNLDEK---AKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
Query: 476 TL----HELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQ 531
L EL+ + + +Q+E++ L E + + ++ + T N+L + H + + +
Sbjct: 748 QLLSQVKELSMVTELRAQVKQLEMN-LAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAK 806
Query: 532 HLNERYQAMLEQLQSLGLNPNSFAASVR----DLQNENFMLKETCKKEHSEKEALREKSK 587
+ + + + +L + L + + +R LQN+ + E ++ + E S+
Sbjct: 807 SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQ 866
Query: 588 DMNEVLMENACMEFSLLGLNDELDGLRGTVKE-IQQFCQV----------LQEEKSILAD 636
+++ +E M+ LL +++ L+ T++E QQ ++ L EEK L
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV 926
Query: 637 EKSTLLSQLQIIT---ESMQKILENNTVLEKSLSDAKIEFEGL-RIKSGDLEDCCKLLND 692
E TL QL +++ E+ ++ +E + + L E +I +L+ LL
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 693 E----KNNLQN---ERSMLISQLEIVEEKLSNL----EKKVTNLEEKYADVEKDKE---- 737
E K LQ R L+ ++ +EE+L+NL +K++ E + +VE+DKE
Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 738 ------SAVNQVEELFASILVQKENHSNH-KHSSEARLANLENIVRVLQE-----EQRLG 785
S ++E + +KE H + E +LA E ++++ + +
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106
Query: 786 KVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESEN 845
+++ Q A I+ I N + + + L+ E + S + E
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSN-TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165
Query: 846 LMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKI--ESLE 903
++ L +E+ L + + + K + + E+K+++ +R+ ++ +S E
Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKE 1225
Query: 904 SSLVKSQEENQQLLVENSV--LLGSLQQHQS----EGEKLKLEKKTVEQEFENMREQNVI 957
+ + Q Q+ V S+ L S Q +S G + L K T + + + E N
Sbjct: 1226 NENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN-- 1283
Query: 958 LQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIEL------------RQTNQ 1005
L D E+ L+ G + K+ L ++AE +EL +++ +
Sbjct: 1284 LCPDWPSHSEDASALQ-----GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEE 1338
Query: 1006 VF--QEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTEN 1063
VF QE+ K E SL + VS +A+ AE + L ++ L + E+ +
Sbjct: 1339 VFQLQEQINKQGLEIESL-KTVS--HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 1064 MVEKRALCEHLGNLSHLNNDLNQEFGVLRK-NFEVKEAENVYLNESIERMDKELLEMDKR 1122
++K + + ++S+L+ L+++ L K E+ E E++ + +++ + E D+R
Sbjct: 1396 ELQK-LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL-IKALHTQLEMQAKEHDER 1453
Query: 1123 LKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETL 1182
+K + E + EE+ E +I+ L ++ + E +K E L+ A T+
Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTI 1513
Query: 1183 QFEMKTLLHEVE-----QHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLAL 1237
+ K+L +VE Q++ ++ L L +E KL + + +SS C +L
Sbjct: 1514 ERLTKSLA-DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESL 1572
Query: 1238 ---LESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSL 1294
LE + + K ++ S+K E+ +E L+ E Y L+ S
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE----------YEILLQSY 1622
Query: 1295 KEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLT 1354
+ N E I VV Q+ + LR S ++ ++ + + ++
Sbjct: 1623 ENVSNEAERI-------QHVVEAVRQEKQELYGKLR--STEANKKETEKQLQEAEQEMEE 1673
Query: 1355 LQTRIRAVEK------IMMEELKRRVKQKSLTTESTPYSSLE--IATYPKVENRKKEIEL 1406
++ ++R K + +EE R++ + T +E +++ ++ + +++
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
Query: 1407 VEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELC------- 1459
E + + K L + L ++D SK E +D+ +
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 1460 --ENNEHEPLS---APTVDHAMICHRSDDSGRYLNYSSELDIEKEL-GVDKL-------- 1505
E E + LS PT ++ +S + ++SS +I L +D+L
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 1506 ---ELSKSVKEKTEDDKRRILERLSSDGQKLAIL-----KMALQDLKKKTETKKKSKQGN 1557
+ +K + E++K +L ++S+ +L +L KM L + + + E + +K
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL-- 1911
Query: 1558 DIEYETVKRHIEEVEEAVMQQVS-INDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQ 1616
ET + +++EE +M Q++ +N + ++ D +I L+ E++
Sbjct: 1912 ---KETAEEEKDDLEERLMNQLAELNGSIGNYCQD---VTDAQIKNE------LLESEMK 1959
Query: 1617 NIQYILLKLAEENNNKVKNR 1636
N++ + +L EE VK +
Sbjct: 1960 NLKKCVSELEEEKQQLVKEK 1979
Score = 124 bits (311), Expect = 2e-27
Identities = 335/1638 (20%), Positives = 684/1638 (41%), Gaps = 201/1638 (12%)
Query: 48 EEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNS 107
E+ +++ + + L VE + L E+ + + E + + + E
Sbjct: 286 EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM--- 342
Query: 108 AYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDA 167
+++L G + ES SA +K++ EE + +L++ ++QS DA
Sbjct: 343 -HHLLEQFEQAGQAQAELESRYSAL----EQKHKAEMEEKTSHILSLQKTGQELQSACDA 397
Query: 168 LFLQYQESLENLSKMETDLNKAQNNARGLDDRASE--AEIQVEILKESLMQLK-ADKDAG 224
L Q + L++ K E + AQ + L+D+ + EI + + L Q + A + +
Sbjct: 398 LKDQNSKLLQD--KNEQAVQSAQ-TIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSF 454
Query: 225 EVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENK 284
+YN+ + + QK +E +N K L ++ + + + ++ L ++
Sbjct: 455 PDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK-------LSSQ 507
Query: 285 IALAEENSRMLNDQIERTELEVETLRKNLAEMNEE--RDSLSVLYHHCLEKISKMENEIL 342
I L E +R E +E+ + + + EE +D L + +++S + E+
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
Query: 343 HVQENAEQLKNKIE-KEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKH 401
QE LK +++ K AE+ + H + +K + Q+E E + K LE
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEAD----HEVLDQKEMK--QMEGEGIA---PIKMKVFLE-- 616
Query: 402 TEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKE--QRNLALELK-------YGLLL 452
+ + LM E S+ +E QA + S++ +E + +ELK L
Sbjct: 617 -DTGQDFPLMPNEESSLPAVEKE-QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSA 674
Query: 453 LKDLELSKQDFKEEMQG-IVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHT 511
+ D+ QD E ++ I+E H+ ++L ++ EIS L ++ E+ ++
Sbjct: 675 VPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADN 734
Query: 512 STEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKET 571
++ L E Q+ ++ L+ + Q++ L +N + A R L E+ +
Sbjct: 735 NSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMN-LAEAERQRRLDYESQTAHDN 792
Query: 572 CKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQ-QFCQVLQEE 630
E ++ KSKD+ +++N ++ L +++ +R ++Q + +VL+
Sbjct: 793 LLTEQIHSLSIEAKSKDVKIEVLQNE-LDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA 851
Query: 631 K-----SILADEKSTLLSQLQI-ITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLE 684
+ S +E S LSQ ++ IT+ Q +LE +E + + + + S +
Sbjct: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 685 DCCKLLNDEKNNLQNERSMLISQLEIV-------EEKLSNLEKKVTNLEEKYADVEKDKE 737
+ LN+EK +L E L QL ++ +E++ + + L++ Y ++ +
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 738 SAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVV 797
+ +++ F L++KEN + A + E + RV + E+ L ++ E + + +
Sbjct: 972 ISKEELQHEFD--LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE-IP 1028
Query: 798 NAQIEMFILQNCIEELELKNFVLLTECEKLVEASK--FSDKVISELESENLMQLIEEEFL 855
++ E ++ E E + ++C+++ K S+K E+E +++ + +EE+
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK---EVELQHIRKDLEEK-- 1083
Query: 856 LHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQ 915
L +F+ + ++ LQ + N+I + IS I+ L +S + + +
Sbjct: 1084 LAAEEQFQALVKQMNQTLQDKT-----NQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
Query: 916 LLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIE 975
LV+ +V++ SE K +LE+K + E E +EQ LQK E L + +
Sbjct: 1139 ALVKETVVISPPCTGSSEHWKPELEEKILALEKE--KEQ---LQKKLQEALTSRKAI--- 1190
Query: 976 VVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSA 1035
+ EKE + L + + L++ +EN + D+ L V + D K +
Sbjct: 1191 LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
Query: 1036 EDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNF 1095
D+ L E T+ ++E LC + S + L V +
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESN-LCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 1096 EVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLD 1155
++KE E E+++ E LK + T++ EL + EE +++E ++
Sbjct: 1310 QLKEIE-------AEKVELE-------LKVSSTTS--------ELTKKSEEVFQLQEQIN 1347
Query: 1156 RQILE-QSENCMNHKKEI--EHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKEN 1212
+Q LE +S ++H+ E+ E L + E+ Q ++ L H +RE L+ L K
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH------LRELQPKLDELQKLI 1401
Query: 1213 EFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLE-NEHMREI-I 1270
K E + + L L +++++ E + K L + ++ E +E ++++ +
Sbjct: 1402 SKK--EEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459
Query: 1271 SLLE-----SEIG---GLKEQL-----SAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGN 1317
L E EIG K+Q+ +A + +LKE+ + E +SL R ++
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL---ARGTI--- 1513
Query: 1318 GAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQK 1377
+ + ++ S SA+ E D V L L R +K++ E + ++ +
Sbjct: 1514 ----ERLTKSLADVESQVSAQNKE----KDTVLGRLALLQEER--DKLITEMDRSLLENQ 1563
Query: 1378 SLTTESTPYSSLEIATYPKVENRKKEIELVE----ENVFDRNSWRKKPKIRLLMKDIPLD 1433
SL S+ SL++A E+++K ++ +E + + W++K K++ +
Sbjct: 1564 SL---SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK------HKELQKE 1614
Query: 1434 RNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSE 1493
+ Q+ + + E R HV+E + E RS ++ +
Sbjct: 1615 YEILLQSYENVSNEAERI-QHVVEAVRQEKQELYGK---------LRSTEANKKETEKQL 1664
Query: 1494 LDIEKELGVDKLELSKSVKEK--------TEDDKRR----------------ILERLSSD 1529
+ E+E+ K ++ K K K E+D+ R +L +S
Sbjct: 1665 QEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
Query: 1530 GQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEE--VEEAVMQQVSINDQMAK 1587
++L +KM + L KK ++ K E + +K IE+ ++A ++ +D
Sbjct: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTN 1784
Query: 1588 NVEEGASSLDREIPRRGS 1605
EEG S+ E + S
Sbjct: 1785 VTEEGTQSIPGETEEQDS 1802
Score = 122 bits (306), Expect = 8e-27
Identities = 325/1692 (19%), Positives = 675/1692 (39%), Gaps = 313/1692 (18%)
Query: 129 TSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQY-QESLENLSKMETDLN 187
T + + K+++SS E E++ ++ L + + L Q Q E ++ T++
Sbjct: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183
Query: 188 KAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQC--LETIARL--ESMLS 243
+ + + E E + L+ L Q +A++ A +V+ + ET RL + +L
Sbjct: 184 EFVM----MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQ 239
Query: 244 QKDNIEAKNLKQELTRVVVQKDTVLLQYKQCL----EKIPMLENKIALAEENSRMLNDQI 299
+ + Q+ RV+ +K L ++++ L + + +L+ ++ AE+ +++L+ Q+
Sbjct: 240 LVTQADVETEMQQKLRVLQRK---LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296
Query: 300 ERTELEVETLRKNL-AEMNEERDSLSVLYHHCLEK---ISKMENEILHVQENAEQL-KNK 354
++ E E TLR + E E + L + E+ ++ E+ H+ E EQ + +
Sbjct: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
Query: 355 IEKEAEKLEISEKHRG----------MLEKSNQNLQLEAENLVQR----IASKDHELLEK 400
E E+ + +KH+ L+K+ Q LQ + L + + K+ + ++
Sbjct: 357 AELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS 416
Query: 401 HTEIERLQTLMH---GEHSNFI------QIESALQ-ALQKLYSQSQK----------EQR 440
I++L+ + E S F+ Q E+A Q + +Y++ + ++R
Sbjct: 417 AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKR 476
Query: 441 NLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEI----- 495
+ LE + G LLL +EL ++ K E + + + L N + + ++ I
Sbjct: 477 VVELENEKGALLLSSIEL--EELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIAN 534
Query: 496 ----SKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAM----------- 540
S + ++ LE F +E +VL E + +++I L + Q
Sbjct: 535 KRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
Query: 541 ---LEQLQSLGLNPNSFAASVRDL-QNENFMLKETCKKEHSEKE--ALREKSKDMNEVLM 594
++Q++ G+ P + D Q+ M E EKE + +S+ E+ +
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
Query: 595 ENACMEF---------SLLGL-------NDELDGLRGTVKEIQQFCQVLQEEKSILADEK 638
+A +E SL + DEL+ L+ + E++ QE DEK
Sbjct: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK 714
Query: 639 STLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQ 698
+ +S L + E +K +NN+ +LS+
Sbjct: 715 AKEISNLNQLIEEFKKNADNNSSAFTALSE------------------------------ 744
Query: 699 NERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEK----DKESAV---NQVEELFASIL 751
ER L+SQ++ + ++ L +V LE A+ E+ D ES N + E S+
Sbjct: 745 -ERDQLLSQVKEL-SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLS 802
Query: 752 VQKENH-------SNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRV--VNAQIE 802
++ ++ N + + + ++R LQ + + + E + +RV +++++E
Sbjct: 803 IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
Query: 803 MFILQNCIEELELKNFVLL-----TECEKLVEASKFSDKVISELE---SENLMQLIEEEF 854
+ELE+ L + E L + + D+ ++E+ +E ++QL EE+F
Sbjct: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
Query: 855 LLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQ 914
L G + + KE++ +L + E + + +
Sbjct: 923 SL-----------------------GVEIKTLKEQL---NLLSRAE---------EAKKE 947
Query: 915 QLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRI 974
Q+ +N V G Q + ++ K+ ++ EF+ ++++N +K K++ NR+ +
Sbjct: 948 QVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENE-QRKRKLQAALINRKELL 1006
Query: 975 EVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEK--NSLCRNVS-DLKDA 1031
+ V+ +E+E + + + + E + +V +++ K EK S C+ + LK
Sbjct: 1007 QRVSRLEEELANLKDESKKEIPLSE-TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 1032 KSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVL 1091
S E E + H L E F + L + + L ++++ ++
Sbjct: 1066 ISEKEVE---LQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII 1122
Query: 1092 RK----NFEVKEAENV----------------------YLNESIERMDKELLEMDKRLKA 1125
+K N + + ++V L E I ++KE ++ K+L+
Sbjct: 1123 QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE 1182
Query: 1126 AETSN-------AEFSRHI-EELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNE 1177
A TS E RH+ EELK ++++ +++E D Q KE E++ +
Sbjct: 1183 ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ-----------SKENENIGD 1231
Query: 1178 ANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSIC--L 1235
LQ +++ + ++E+ + +E FK E + S++C
Sbjct: 1232 QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT---QPVLESNLCPDW 1288
Query: 1236 ALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLK 1295
S L G + ++ K +E E + LE ++ +L+ V L+
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVE-----LELKVSSTTSELTKKSEEVFQLQ 1343
Query: 1296 EDFN--SLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLL 1353
E N LE SL K V E + S Q E+ + I G+ L
Sbjct: 1344 EQINKQGLEIESL--------------KTVSHEAEVHAESLQQKLESSQLQIA-GLEHLR 1388
Query: 1354 TLQTRIRAVEKIMMEE------LKRRVKQK-----SLTTESTPYSSLEIATYPKVENRKK 1402
LQ ++ ++K++ ++ L ++ +K + TE L A + ++E + K
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448
Query: 1403 E-IELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCEN 1461
E E +++ + ++KP ++I + Q + L+ + + E
Sbjct: 1449 EHDERIKQLQVELCEMKQKP------EEIGEESRAKQQIQRKLQAALISRKEALKENKSL 1502
Query: 1462 NEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRR 1521
E L+ T++ +S S + EK+ + +L L + ++K + R
Sbjct: 1503 QEELSLARGTIERLTKSLADVES-----QVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 1522 ILERLSSDGQKLAILKMALQDLK-------KKTETKKKSKQGNDIEYETVKRHIEEVEEA 1574
L S LK+AL+ L K+ E+ K SK E++ + +++ E
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
Query: 1575 VMQ---QVSINDQMAKNVEEGASSLDREI----------PRRGSEQIGKLQFEVQNIQYI 1621
++Q VS + ++V E +E+ + +Q+ + + E++ ++
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
Query: 1622 LLKLAEENNNKV 1633
+ K A+ K+
Sbjct: 1678 MRKFAKSKQQKI 1689
Score = 122 bits (305), Expect = 1e-26
Identities = 230/1252 (18%), Positives = 498/1252 (39%), Gaps = 181/1252 (14%)
Query: 39 KVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVE--EFYR--AYRALAERYDHAMGELR 94
+++ ++K ++E + Y +K L + V+ EF + + + L ++ +
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 95 HAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGE--VQ 152
H K E +++ +L DD+ + A++ + +K++ +S + E +
Sbjct: 2069 HRKKAQAEL---ASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER 2125
Query: 153 TLREALAK-------MQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEI 205
L +A K MQ DAL + E + +++ LNK + L +
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
Query: 206 QVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKD 265
Q+ +S+ L+ D+D + ++ + E S + + ++ + V KD
Sbjct: 2186 QLAAFTKSMSSLQDDRD-------RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
Query: 266 TVLLQYKQCLEKIPMLENKIALAE-ENSRMLNDQIERTELEVE-----TLRKNLAEMNEE 319
Q +Q I M E KI ++ E+ + + + +TE++++ TL+ E+ +
Sbjct: 2239 ----QLRQM--SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQ 2292
Query: 320 RDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEK---------------------- 357
+ LYH +++K+E+E+ +++ L N +EK
Sbjct: 2293 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 358 --EAEKLEIS-EKHRGMLEKSNQNLQLEAENLVQRIASKDH-------ELLEKHT-EIER 406
E+LE + R + + ++ + ++ + ++ ++ K+ EL ++H EI+
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE 2412
Query: 407 LQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEE 466
L+ L+ E I +E + +Q + + + E L S + +
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
Query: 467 MQGIVEENKTLHELNFSSTRSLKKQQM------EISKLKEIKEKLEREFHTSTEESNVLQ 520
IV + + L E + S L+K Q+ E +KLKE L E+ L
Sbjct: 2473 RDRIVGDYQQLEERHLSII--LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD 2530
Query: 521 RETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKE 580
E Q ++D+ + + +QL + L N ++L+N+ L+E K+ E
Sbjct: 2531 AELIQYREDLNQVITIKDSQQKQLLEVQLQQN------KELENKYAKLEEKLKESEEANE 2584
Query: 581 ALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKST 640
LR + E + L+ E++ L+ ++ ++ + LQEE ++
Sbjct: 2585 DLRRSFNALQEEKQD----------LSKEIESLKVSISQLTRQVTALQEEGTL-----GL 2629
Query: 641 LLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRI----KSGDLEDCCKLLNDEKNN 696
+QL++ E + ++ + +K +++ + E ++ K G++ED L E +
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED---KLKKELKH 2686
Query: 697 LQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASI--LVQK 754
L ++ ++ ++ E EE+++ L + + +E+K V K+ + Q++ S+ L
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746
Query: 755 ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELE 814
+H+N + R + ++ L + + G + E++ A +N + LE
Sbjct: 2747 RDHANEELDELKR--KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE 2804
Query: 815 LKNFVLLTECEKLVEASKFSDKVISELESENLMQLI---EEEFLLHRIRKFK-------- 863
N LL++ E+L+ S + ++++S + E + L + + KF+
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQR 2864
Query: 864 ------------MDIHKVCGVLQIDSDG--GGDNEIKKEEIPISRILDKIESLESSLVKS 909
+ K LQ D D ++++ + I++ + ++ L++ L +
Sbjct: 2865 SAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Query: 910 QEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEEN 969
Q++ + + L Q E +L++EK + E M+EQ ++ DK + L
Sbjct: 2925 QDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH- 2983
Query: 970 RQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLK 1029
+ + +E RS S+ Q + ++++ Q E + +N V + +
Sbjct: 2984 -------LQNLIRELRSSSS----QTQPLKVQYQRQASPETSASPDGSQNL----VYETE 3028
Query: 1030 DAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFG 1089
++ D + L + LN F++ + EK L L + S + Q +G
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLN----SNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084
Query: 1090 VLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTK 1149
L + V L + ++ + L +D A + N + E E ++S
Sbjct: 3085 DLLNHCAV-------LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQS-- 3135
Query: 1150 IKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREE 1201
E + N ++E+ E++ LL E RV E
Sbjct: 3136 --------FSEAQQQLCNTRQEVN-----------ELRKLLEEERDQRVAAE 3168
Score = 104 bits (260), Expect = 2e-21
Identities = 297/1510 (19%), Positives = 619/1510 (40%), Gaps = 193/1510 (12%)
Query: 236 ARLESMLSQKDNIEAKNLKQE-LTRVVVQKDTVLLQYKQCL-EKIPMLENKIALAEENSR 293
A L+ L Q+ ++E N QE + + + ++++ K + +K L+ K +E +
Sbjct: 28 APLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERK 87
Query: 294 MLNDQIERTELEVE----TLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAE 349
+++I++ +L + +L K + EM + ++ E++SK + + E
Sbjct: 88 AADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
Query: 350 QLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQT 409
++K+K++ EK E+ + L ++ ++ ++ +L EK I LQ
Sbjct: 148 KIKHKLQ---EKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQA 204
Query: 410 LMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQD------- 462
+ + Q E A Q + + + Q L + L+ D+E Q
Sbjct: 205 QL-----SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQR 259
Query: 463 -FKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEK---LEREFHTSTEESNV 518
+E + +V + + L T + ++ Q+ +L++++ + L T EES +
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI 319
Query: 519 LQRET-----------HQIKDDIQHLNERY----QAMLEQLQSLGLNPNSFAASVRDLQN 563
L + H +++++ HL E++ QA E A + + +
Sbjct: 320 LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379
Query: 564 ENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQF 623
L++T ++ S +AL++++ + + E A S + D L+ KEI QF
Sbjct: 380 HILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQ--SAQTIQQLEDQLQQKSKEISQF 437
Query: 624 CQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTV-LEKSLSDAKIEFEGLRIKSGD 682
L ++ E ++ S + E Q + E N L+K + + + E L + S +
Sbjct: 438 LNRLPLQQ----HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 683 LEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQ 742
LE+ L+ E L SQ+ ++E + E E D+ + S+
Sbjct: 494 LEE-----------LKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS--- 539
Query: 743 VEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFE----QELDRVVN 798
EE +L EN + KH E + LE ++ QEE K++ + +E D V
Sbjct: 540 AEESGQDVL---ENTFSQKH-KELSVLLLE--MKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 799 AQIEMFILQ-NCIEELELKNFVLLTECEKLVEASKFSD--KVISELESENLMQLIEEEFL 855
Q EM ++ I +++K F+ T + + ++ S V E S EE
Sbjct: 594 DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEIS 653
Query: 856 LH----RIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQE 911
L+ ++ K D K L D G + ++E + R+ +I LE + K+QE
Sbjct: 654 LNDAGVELKSTKQDGDK---SLSAVPDIG---QCHQDE--LERLKSQILELELNFHKAQE 705
Query: 912 ENQQLLVENSVLLGSLQQHQSEGEK-----------LKLEKKTV---EQEFENMREQNVI 957
++ L E + + +L Q E +K L E+ + +E + E
Sbjct: 706 IYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQ 765
Query: 958 LQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKM--- 1014
+++ ++ L E RQ R++ + +N + +L E +V Q E +
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQ 825
Query: 1015 LDEKNSLCRNV-SDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEH 1073
E+++L R++ S L++ +S + + H + L+ E + L E
Sbjct: 826 FSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEK 885
Query: 1074 LGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEF 1133
++ L + + K+ +V E + + E + ++++E + +K +
Sbjct: 886 KRDVETLQQTIEE------KDQQVTEI-SFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLL 938
Query: 1134 SRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEH----LNEANETLQFEMKTL 1189
SR E K + EE ++ L + E S K+E++H L + NE + +++
Sbjct: 939 SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998
Query: 1190 LHEVEQHRVREEALNLELLNKENEFK----LWENEAAAFYHDLQMSSICLALLESKVSEL 1245
L ++ R L EL N ++E K L E E D + + SK E+
Sbjct: 999 LINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI 1058
Query: 1246 TGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVS-SLKEDFNSLEHI 1304
L S K +E +H+R+ LE ++ +EQ A V ++ +L++ N ++ +
Sbjct: 1059 E---IYLKQTISEKEVELQHIRKD---LEEKLAA-EEQFQALVKQMNQTLQDKTNQIDLL 1111
Query: 1305 SLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIP--DGVSD--LLTLQTRIR 1360
++ +++ QK + T + + +V+ P G S+ L+ +I
Sbjct: 1112 QAEISENQAII----QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKIL 1167
Query: 1361 AVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEI-ELVEENVFDRNSWRK 1419
A+EK E+L++++ Q++LT+ A K + +++ + E +++ D N ++
Sbjct: 1168 ALEK-EKEQLQKKL-QEALTSRK--------AILKKAQEKERHLREELKQQKDDYNRLQE 1217
Query: 1420 KPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNE--------HEPLSAPT 1471
+ + + N+ DQ + L+ + R + D L + E EPL T
Sbjct: 1218 Q-----FDEQSKENENIGDQ-LRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT 1271
Query: 1472 VDH-------AMIC----HRSDDSGRYLNYSSELDIE---KELGVDKLELSKSVKEKTED 1517
H + +C S+D+ +S I+ KE+ +K+EL V T +
Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE 1331
Query: 1518 DKRR------ILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEV 1571
++ + E+++ G ++ LK + + E+ ++ + + ++ ++ H+ E+
Sbjct: 1332 LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLREL 1390
Query: 1572 EEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYILLKL------ 1625
+ + + ++ EE S L ++ + + K+Q E+ + ++ L
Sbjct: 1391 QPKLDEL----QKLISKKEEDVSYLSGQLSEK-EAALTKIQTEIIEQEDLIKALHTQLEM 1445
Query: 1626 -AEENNNKVK 1634
A+E++ ++K
Sbjct: 1446 QAKEHDERIK 1455
Score = 37.4 bits (85), Expect = 0.35
Identities = 95/575 (16%), Positives = 227/575 (38%), Gaps = 71/575 (12%)
Query: 1096 EVKEAENVYLNESIERMDKELLEMDKRLKA----AETSNAEFSRHIEELKMEQEESTKIK 1151
++ ++V L + E + +E D ++K A+ +++IEE+K + +
Sbjct: 66 DIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
Query: 1152 ENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKE 1211
+ Q+ + ++ + EIE + + + + TL ++ Q + + A + + +
Sbjct: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 185
Query: 1212 NEFKLWENEAAAFYHDL-------QMSSICLALLESKVSELTGVCKILDDE----SSAKS 1260
K E F L Q ++ K + ++ +DE +
Sbjct: 186 VMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQAD 245
Query: 1261 LENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQ 1320
+E E M++ + +L+ ++ +E L +V L+++ + E +RN ++ Q
Sbjct: 246 VETE-MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE-------QRNQILSQQLQ 297
Query: 1321 KDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLT 1380
+ LR E++I+L + + L+ A K+ L+ +
Sbjct: 298 QMEAEHNTLRNTVETEREESKILL------EKMELEV---AERKLSFHNLQEEMHHLLEQ 348
Query: 1381 TESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQN 1440
E + E+ + +K + E+ E+ + + +++ + DQN
Sbjct: 349 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL------KDQN 402
Query: 1441 SKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHA--MICHRSDDSGRYLNYSSELDIEK 1498
SK L+ + NE SA T+ + +S + ++LN L +++
Sbjct: 403 SKLLQ--------------DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN---RLPLQQ 445
Query: 1499 ELGVDKLEL----SKSVKEKTEDDKRRILER-LSSDGQKLAILKMALQDLKKKTETKKKS 1553
+ ++ + TE++ + +R + + +K A+L +++ + K E +K S
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLS 505
Query: 1554 KQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQF 1613
Q +E + + E + + V I ++ + + EE + + +++ L
Sbjct: 506 SQITLLEAQNRTGEADR-EVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLL 564
Query: 1614 EV----QNIQYILLKL----AEENNNKVKNRISRK 1640
E+ + I ++ L+L AEE +++V ++ K
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599
>C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 190)
(Microtubule binding protein 190) (d-CLIP-190)
Length = 1690
Score = 159 bits (402), Expect = 6e-38
Identities = 259/1193 (21%), Positives = 494/1193 (40%), Gaps = 189/1193 (15%)
Query: 150 EVQTLREALAKMQSDKDALFLQYQES----LENLSKMETDLNKAQNNARGLDD---RASE 202
E+ L+E + Q + ++ + E EN+ + + Q+ D+ + S
Sbjct: 489 EIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSL 548
Query: 203 AEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVV 262
+E +E L+ L LK + + Q E A L++K ++E L EL +
Sbjct: 549 SECGIENLRRELELLKEENE------KQAQEAQAEFTRKLAEK-SVEVLRLSSELQNLKA 601
Query: 263 QKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDS 322
D++ + ++ +L+ ++ + +E R LN Q++ ++ + + + ++ D
Sbjct: 602 TSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALD---DM 658
Query: 323 LSVLYHHCLEK---ISKMENEILHVQENA-------EQLKNKIEKEAEKLEISEKHRGML 372
L + EK + K E E++ +E A EQL+ +I + E + R M
Sbjct: 659 LRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 718
Query: 373 EKSNQNLQLEAENLVQRIASKDHEL-----LEKHTEIERLQTLMHGEHSNFIQIESALQA 427
E + +QLE E++ Q++A K +EL + +E+ + +F +ES ++
Sbjct: 719 ENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESG-ES 777
Query: 428 LQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIV-EENKTLHELNFSSTR 486
L+KL Q Q EQ+ L E L+ + ++ K+E + I+ E+ + L +L S
Sbjct: 778 LKKL--QQQLEQKTLGHE---------KLQAALEELKKEKETIIKEKEQELQQLQSKSAE 826
Query: 487 S---LKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQ 543
S LK Q+++ E+L+++ S EE + + H D+I L + + +
Sbjct: 827 SESALKVVQVQL-------EQLQQQAAASGEEGSKTVAKLH---DEISQLKSQAEETQSE 876
Query: 544 LQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSL 603
L+S ++ A + L+ N L+E KK
Sbjct: 877 LKS---TQSNLEAKSKQLEAANGSLEEEAKKSGH-------------------------- 907
Query: 604 LGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILE-NNTVL 662
L +++ L+ V E Q LS ES K LE N L
Sbjct: 908 --LLEQITKLKSEVGETQ------------------AALSSCHTDVESKTKQLEAANAAL 947
Query: 663 EKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKN-NLQNER---SMLISQLEIVEEKLSNL 718
EK E+ R ++ DL+D K + D + LQ ER S L ++L ++++
Sbjct: 948 EK----VNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATG 1003
Query: 719 EKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVL 778
K++T+ + ++ KE +++EL + +++ + K E + + E ++ L
Sbjct: 1004 HKELTSKADAWSQEMLQKE---KELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNL 1060
Query: 779 QEEQRLGKVEFEQELDRVVNAQIEMFILQNCIE----ELELKNFVLLTECEK------LV 828
QEE K E L+ Q + LQ +E EL+ K + + +K LV
Sbjct: 1061 QEEVTKAKTE---NLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLV 1117
Query: 829 EASKFSDKVISELESE--NLMQLI--EEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNE 884
EA + ++ IS +E +++++ E+ H F+M+ L I+ G E
Sbjct: 1118 EAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERL-IEKVTGIKEE 1176
Query: 885 IKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSV---LLGSLQQHQSE-GEKLKLE 940
+K+ + + K E LE L ++Q+ Q+L E+ L +QQ E + +K +
Sbjct: 1177 LKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQK 1236
Query: 941 KKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIEL 1000
++ V+ E +RE + I++ +L E N QL EN++ S L Q +++E
Sbjct: 1237 EELVQNLEEKVRESSSIIEAQNTKLNESNVQL----------ENKT-SCLKETQDQLLES 1285
Query: 1001 RQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFF 1060
++ + QEE K+ E + D+KD+ E+ V+ + A ++
Sbjct: 1286 QKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQ-------L 1338
Query: 1061 TENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMD 1120
+ L E L +L E + + + E N L E++ + + L E+
Sbjct: 1339 DAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQ 1398
Query: 1121 KRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANE 1180
+L + T + E++ + E++ + + L + + +E ++ L +ANE
Sbjct: 1399 GKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAE-------QLSQLKQANE 1451
Query: 1181 TLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDL----QMSSICLA 1236
LQ ++Q ++ LL K NEF E ++ + S L
Sbjct: 1452 ELQ-------KSLQQKQL--------LLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLE 1496
Query: 1237 LLESKVSELTGVCKILDDESSAKSLENEHMREIISLLE----SEIGGLKEQLS 1285
L+++V+EL + +D LE + +R + LE E+ LK Q++
Sbjct: 1497 QLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMN 1549
Score = 127 bits (320), Expect = 2e-28
Identities = 262/1302 (20%), Positives = 523/1302 (40%), Gaps = 203/1302 (15%)
Query: 283 NKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKI-------- 334
N IA + +N Q ++ V+ + +D L H +EK+
Sbjct: 333 NSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQH-VEKLMVERDLDR 391
Query: 335 SKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENL---VQRIA 391
+N+ L +Q+N +LK +I + L+ K L+ S Q + L Q
Sbjct: 392 EDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYK 451
Query: 392 SKDHELLEKHTEI----ERLQTLMHGE-HSNFIQIESALQALQKLYSQSQKE-------- 438
K H+L K T++ LQ+++ + S+ ++ + LQ+ + QKE
Sbjct: 452 EKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQ 511
Query: 439 ---QRNLALELKY---------GLLLLKDLELSK--------QDFKEEMQGIVEEN-KTL 477
++ L +KY L+ KD L K ++ + E++ + EEN K
Sbjct: 512 LEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQA 571
Query: 478 HELNFSSTRSLKKQQMEISKL-------KEIKEKLEREFHTSTEESNVLQRETHQIKDDI 530
E TR L ++ +E+ +L K + LE E T+E +LQ E + I
Sbjct: 572 QEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQI 631
Query: 531 QHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMN 590
+ LN++ + QL + ++ +R LQ E K T E +EKE ++ K
Sbjct: 632 RELNQQLDEVTTQLNVQKADSSALDDMLR-LQKEGTEEKSTLL-EKTEKELVQSK----- 684
Query: 591 EVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
E + LND+ + L + +++Q L E++ ++ + ++Q+Q+ E
Sbjct: 685 ---------EQAAKTLNDK-EQLEKQISDLKQ----LAEQEKLVREMTENAINQIQLEKE 730
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEI 710
S++ + L +K +LED K ++ + +LQ ++ +
Sbjct: 731 SIE--------------------QQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 770
Query: 711 VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN 770
+ E +L+K LE+K EK ++A+ ++++ +I+ +KE S A +
Sbjct: 771 LVESGESLKKLQQQLEQKTLGHEK-LQAALEELKKEKETIIKEKEQELQQLQSKSAESES 829
Query: 771 LENIVRV-LQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVE 829
+V+V L++ Q+ E+ V E+ L++ EE + + L + L
Sbjct: 830 ALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE---LKSTQSNLEA 886
Query: 830 ASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVL------------QIDS 877
SK + LE E + LL +I K K ++ + L Q+++
Sbjct: 887 KSKQLEAANGSLEEEAK----KSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEA 942
Query: 878 DGGGDNEIKKE----EIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSE 933
++ KE S + DK++ + +L + + L +
Sbjct: 943 ANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIAT 1002
Query: 934 GEKLKLEKKTV--------EQEFENMREQNVILQKDKVELLEEN-----------RQLRI 974
G K K E+E + +R+Q Q + +L E + L+
Sbjct: 1003 GHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQE 1062
Query: 975 EVVNG----VEKENRSKSTLAALQAEM----IELRQTNQVFQEENGKMLDEKNSLCRNVS 1026
EV +E +++T+ LQ + EL+ ++ E+ K+ D K +
Sbjct: 1063 EVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLV--EAI 1120
Query: 1027 DLKDAKSSAEDENSVMFHDVLAL--SNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDL 1084
+ +A SA + +VL S N ++E+F E + L E + + +
Sbjct: 1121 QVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKET 1180
Query: 1085 NQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQ 1144
+ + +K FE E + +S +++ +E ++L E + ++EL+
Sbjct: 1181 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKL-------TEIQQSLQELQDSV 1233
Query: 1145 EESTKIKENLDRQILEQSE--NCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEA 1202
++ ++ +NL+ ++ E S N K LNE+N +Q E KT + Q
Sbjct: 1234 KQKEELVQNLEEKVRESSSIIEAQNTK-----LNESN--VQLENKTSCLKETQD------ 1280
Query: 1203 LNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLE 1262
+LL + + K + EAA +LQ ++ + ++ + K+L+++ A + +
Sbjct: 1281 ---QLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQ 1337
Query: 1263 -------NEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVV 1315
N+ ++E++ + G L+ + A + L++ L+ L K N +
Sbjct: 1338 LDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEA--LCQKENGLK 1395
Query: 1316 ---GNGAQKDVVIETCLRKHSH-----QSARENEIVLIPDGVSDLLTLQTRIRAVEKIMM 1367
G + + V+E+ + H+ + A++ E L + S L ++++
Sbjct: 1396 ELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTL-QEETSKLAEQLSQLKQAN---- 1450
Query: 1368 EELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLM 1427
EEL++ ++QK L E ++A Y KV I+ +++ +++ ++ + R+
Sbjct: 1451 EELQKSLQQKQLLLEKGNEFDTQLAEYQKV------IDEMDDAASVKSALLEQLQNRVAE 1504
Query: 1428 KDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSA 1469
+ L + D Q + YL+ + R LEL ++ E L A
Sbjct: 1505 LETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKA 1546
Score = 98.6 bits (244), Expect = 1e-19
Identities = 163/841 (19%), Positives = 345/841 (40%), Gaps = 106/841 (12%)
Query: 156 EALAKMQSDKDALFLQY---QESLENLSK-METDLNKAQNNARGLDDRASEAEIQVEILK 211
E+L K+Q + L + Q +LE L K ET + + + + L +++E+E +++++
Sbjct: 776 ESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQ 835
Query: 212 ESLMQLK----ADKDAGEVLYNQCLETIARLES--------MLSQKDNIEAKNLKQELTR 259
L QL+ A + G + + I++L+S + S + N+EAK+ + E
Sbjct: 836 VQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAAN 895
Query: 260 VVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEE 319
++++ + LE+I L++++ + + +E ++E L ++N+E
Sbjct: 896 GSLEEEAK--KSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKE 953
Query: 320 RDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNL 379
Y + S +++++ + + E +AE+ S H L K + +
Sbjct: 954 -------YAESRAEASDLQDKVKEITDTLHA-----ELQAERSSSSALHT-KLSKFSDEI 1000
Query: 380 QLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQK-- 437
+ L + + E+L+K E++ L+ + + ++++ + +K + +S K
Sbjct: 1001 ATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNL 1060
Query: 438 -----EQRNLALELKYGL-LLLKDLELSKQ---------------------DFKEEMQGI 470
+ + LEL G +KDL+ + D K ++ I
Sbjct: 1061 QEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAI 1120
Query: 471 VEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEE-----SNVLQ--RET 523
N + N + L+ Q E S+ I E E E ++E + + + +ET
Sbjct: 1121 QVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKET 1180
Query: 524 HQIKDDIQHLNERYQAMLEQLQS----LGLNPNSFAASVRDLQNENFMLKETCKKEHSEK 579
H D+ Q E + L+Q Q L + + ++Q L+++ K++
Sbjct: 1181 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELV 1240
Query: 580 EALREKSKDMNEVL-MENACMEFSLLGLNDELDGLRGT---VKEIQQFCQVLQEEKSILA 635
+ L EK ++ + ++ +N + S + L ++ L+ T + E Q+ + LQEE + L+
Sbjct: 1241 QNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLS 1300
Query: 636 DEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKN 695
E + I +S+ K+ E VLE+ L A + + + + +L++ + +
Sbjct: 1301 GELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEG 1360
Query: 696 NLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKE 755
NLQ E V EKL LE+ L+E E + +++E + QK+
Sbjct: 1361 NLQGESL-------AVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKK 1413
Query: 756 NHSNHKHSSEARLANLENIVRVLQEE-----QRLGKVEFEQE------------LDRVVN 798
+H + + +L + R LQEE ++L +++ E L++
Sbjct: 1414 SH----NEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1469
Query: 799 AQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHR 858
++ Q I+E++ V E+L + + + +E + L +
Sbjct: 1470 FDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQ 1529
Query: 859 IRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEI---PISRILDKIESLESSLVKSQEENQQ 915
+ +++ + L+ +G K +E+ I L KI L S + Q++N
Sbjct: 1530 LESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDA 1589
Query: 916 L 916
L
Sbjct: 1590 L 1590
Score = 85.5 bits (210), Expect = 1e-15
Identities = 127/639 (19%), Positives = 273/639 (41%), Gaps = 71/639 (11%)
Query: 34 TDIDTKVK-------SMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYR----AL 82
TD+++K K ++ K+ +E A+S A +++ K + E+ + +A R AL
Sbjct: 931 TDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVK-EITDTLHAELQAERSSSSAL 989
Query: 83 AERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSK--KN 140
+ E+ HK + + +L + L + ++ +++ +
Sbjct: 990 HTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERK 1049
Query: 141 ERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRA 200
E+S EES ++ L+E + K +++ L Q ++++L + N + +
Sbjct: 1050 EKSFEES---IKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASED 1106
Query: 201 SEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLES-------MLSQKDNIEAKNL 253
++ ++ L E++ A+ A + LE + +S + + ++ ++ L
Sbjct: 1107 AQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERL 1166
Query: 254 KQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNL 313
+++T + + LQ + +K LE K+ A+++ + L + + ++ ++ ++++L
Sbjct: 1167 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSL 1226
Query: 314 AEMNEERDSLSVLYHHCLEKI----SKMENEILHVQENAEQLKNK---IEKEAEKLEISE 366
E+ + L + EK+ S +E + + E+ QL+NK +++ ++L S+
Sbjct: 1227 QELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQ 1286
Query: 367 KHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQ 426
K L++ L E + + + L++ ++ L+ + S ++ +
Sbjct: 1287 KKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNK 1346
Query: 427 ALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKE----------EMQGIVEENKT 476
LQ+L +SQ+ + NL E L+ LE + + KE E+QG ++E+ T
Sbjct: 1347 ELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT 1406
Query: 477 LHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHL--- 533
+ E S KK EI++KLE+ + ++ LQ ET ++ + + L
Sbjct: 1407 VLE-------SQKKSH------NEIQDKLEQ----AQQKERTLQEETSKLAEQLSQLKQA 1449
Query: 534 NERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVL 593
NE Q L+Q Q L N F + + Q K +A KS + ++
Sbjct: 1450 NEELQKSLQQKQLLLEKGNEFDTQLAEYQ----------KVIDEMDDAASVKSALLEQLQ 1499
Query: 594 MENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKS 632
A +E +L ND KE+++ + L+ EKS
Sbjct: 1500 NRVAELETALRQANDAQKTAYLETKELRRQLESLELEKS 1538
Score = 79.3 bits (194), Expect = 8e-14
Identities = 209/1031 (20%), Positives = 422/1031 (40%), Gaps = 142/1031 (13%)
Query: 657 ENNTVLEKSLSDAKIEF---EGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEE 713
+++T ++ L+ K +F + LR K +E + ++ + QN+ L + ++
Sbjct: 351 KSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKA 410
Query: 714 KLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLEN 773
++ LE + N +K +++ + A +EL A V KE H E+++ L +
Sbjct: 411 RIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKI----HDLESKITKLVS 466
Query: 774 IVRVLQEEQRLGKVEFEQEL-DRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASK 832
LQ + L + + Q +M I Q +E+E + L E ++L E K
Sbjct: 467 ATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQ---KEVESRIAEQLEEEQRLRENVK 523
Query: 833 FSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPI 892
+ ++ I+ L+SE L+ ++ + KF + CG+ + + E+ KEE
Sbjct: 524 YLNEQIATLQSE----LVSKD---EALEKFSLS---ECGIENLRRE----LELLKEEN-- 567
Query: 893 SRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMR 952
E ++Q E + L E SV + L SE + LK ++E E N
Sbjct: 568 ----------EKQAQEAQAEFTRKLAEKSVEVLRLS---SELQNLKATSDSLESERVNKT 614
Query: 953 EQNVILQKD---KVELLEENRQLRIEVVNGVEKENRSKSTL---AALQAEMIELRQT--- 1003
++ ILQ + + E + E Q EV + + S L LQ E E + T
Sbjct: 615 DECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLE 674
Query: 1004 ---NQVFQ--EENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEI 1058
++ Q E+ K L++K L + +SDLK AE E V A++ + L
Sbjct: 675 KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQL---AEQEKLVREMTENAINQIQL---- 727
Query: 1059 FFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLE 1118
EK ++ + L + D ++ + + +A+N + + + L +
Sbjct: 728 -------EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKK 780
Query: 1119 MDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKK----EIEH 1174
+ ++L+ + + +EELK E+E K KE +Q+ +S + K ++E
Sbjct: 781 LQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQ 840
Query: 1175 LN--------EANET---LQFEMKTLLHEVE--QHRVREEALNLELLNKENEFK--LWEN 1219
L E ++T L E+ L + E Q ++ NLE +K+ E E
Sbjct: 841 LQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEE 900
Query: 1220 EAAAFYHDLQMSSICLALLESKVSELTGVCKIL--DDESSAKSLEN-----EHMREIISL 1272
EA H L+ + L+S+V E D ES K LE E + + +
Sbjct: 901 EAKKSGHLLEQ----ITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAE 956
Query: 1273 LESEIGGLKEQLSAYVP-LVSSLKEDFNSLEHISLLWTKRNSVVGNG-----AQKDVVIE 1326
+E L++++ L + L+ + +S + +K + + G ++ D +
Sbjct: 957 SRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQ 1016
Query: 1327 TCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVK--QKSLTTEST 1384
L+K E E+ + + D QT+++A + + + +K Q+ +T T
Sbjct: 1017 EMLQK-------EKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKT 1069
Query: 1385 PYSSLEIATYPKVENRKKEIELVEENVFDRNSW-----RKKPKIRLLMKDIPL-DRNVDD 1438
L T +++ ++ +E+ + + +K ++ L++ I + + N+
Sbjct: 1070 ENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISA 1129
Query: 1439 QNSKY------LKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSS 1492
N++ L+ E TN H+ EL E + A +I +
Sbjct: 1130 TNAELSTVLEVLQAEKSETN-HIFELFE------MEADMNSERLIEKVTGIKEELKETHL 1182
Query: 1493 ELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKK 1552
+LD ++ K E + ++ + ++++ + + +KL ++ +LQ+L+ + K++
Sbjct: 1183 QLDERQK----KFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEE 1238
Query: 1553 SKQGNDIEYETVKRHIE----EVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQI 1608
Q + + IE ++ E+ +Q + + + ++ S +E ++ E+
Sbjct: 1239 LVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKE--KQLQEEA 1296
Query: 1609 GKLQFEVQNIQ 1619
KL E+Q +Q
Sbjct: 1297 AKLSGELQQVQ 1307
Score = 75.9 bits (185), Expect = 9e-13
Identities = 115/519 (22%), Positives = 219/519 (42%), Gaps = 90/519 (17%)
Query: 1138 EELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHR 1197
EE+ QE+ T ++ ++ +I EQ E ++ +++LNE TLQ E+ + +E+
Sbjct: 488 EEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFS 547
Query: 1198 VREEAL-----NLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKIL 1252
+ E + LELL +ENE K + A F L S+ + L S++ L L
Sbjct: 548 LSECGIENLRRELELLKEENE-KQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSL 606
Query: 1253 DDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLL---WT 1309
+ E K+ E E ++ + + + +I L +QL ++ K D ++L+ + L T
Sbjct: 607 ESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGT 666
Query: 1310 KRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEE 1369
+ S + +K++V + Q+A+ ++D L+ +I +
Sbjct: 667 EEKSTLLEKTEKELV------QSKEQAAKT---------LNDKEQLEKQI--------SD 703
Query: 1370 LKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKD 1429
LK+ +Q+ L E T EN +I+L +E++ + +L +K
Sbjct: 704 LKQLAEQEKLVREMT-------------ENAINQIQLEKESI----------EQQLALKQ 740
Query: 1430 IPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLN 1489
L+ +++ + H+ E+ N + D ++ +SG L
Sbjct: 741 NELED---------FQKKQSESEVHLQEIKAQNTQK-------DFELV-----ESGESLK 779
Query: 1490 YSSELDIEKELGVDKLELS----KSVKEKTEDDKRRILERLSSDGQK----LAILKMALQ 1541
+ +K LG +KL+ + K KE +K + L++L S + L ++++ L+
Sbjct: 780 KLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLE 839
Query: 1542 DLKKKT----ETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLD 1597
L+++ E K+ E +K EE + + S + +K +E SL+
Sbjct: 840 QLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLE 899
Query: 1598 REIPRRGS--EQIGKLQFEVQNIQYILLKLAEENNNKVK 1634
E + G EQI KL+ EV Q L + +K K
Sbjct: 900 EEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTK 938
Score = 63.2 bits (152), Expect = 6e-09
Identities = 109/539 (20%), Positives = 210/539 (38%), Gaps = 95/539 (17%)
Query: 25 NSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAE 84
NS+ L+E +T I ++K ++E F E + + KL +E + L E
Sbjct: 1162 NSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTE 1221
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
++ EL+ + K E N L +S +K NE S+
Sbjct: 1222 -IQQSLQELQDSVKQKEELVQN--------------LEEKVRESSSIIEAQNTKLNE-SN 1265
Query: 145 EESNGEVQTLREALAK-MQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEA 203
+ + L+E + ++S K LQ E +K+ +L + Q + D +
Sbjct: 1266 VQLENKTSCLKETQDQLLESQKKEKQLQ-----EEAAKLSGELQQVQEANGDIKDSLVKV 1320
Query: 204 EIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQ 263
E V++L+E L + DA + + E + + + + N++ ++L
Sbjct: 1321 EELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQ---ENEGNLQGESL---------- 1367
Query: 264 KDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSL 323
+ K+ E+ + L + + + E ++ L+ L E N
Sbjct: 1368 ----------------AVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT----- 1406
Query: 324 SVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEA 383
LE K NEI E A+Q + +++E KL + L+++N+ LQ
Sbjct: 1407 ------VLESQKKSHNEIQDKLEQAQQKERTLQEETSKL---AEQLSQLKQANEELQKSL 1457
Query: 384 EN---LVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQR 440
+ L+++ D +L E I+ + + + Q+++ + L+ Q+ Q+
Sbjct: 1458 QQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQK 1517
Query: 441 NLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKE 500
LE K L+ LEL K E ++N +S+RS K ++E
Sbjct: 1518 TAYLETKELRRQLESLELEKSR---------EVLSLKAQMNGASSRSGKGDEVE------ 1562
Query: 501 IKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLN---PNSFAA 556
+ TS + N L + I D+Q N+ +A ++ L++L ++ P++F A
Sbjct: 1563 -----SLDIETSLAKINFL----NSIIADMQQKNDALKAKVQTLETLPMDFTKPHAFDA 1612
>MYHB_CHICK (P10587) Myosin heavy chain, gizzard smooth muscle
Length = 1978
Score = 159 bits (401), Expect = 8e-38
Identities = 236/1144 (20%), Positives = 469/1144 (40%), Gaps = 162/1144 (14%)
Query: 126 ESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETD 185
E A+ + ER +++ E++ L + ++ +K+ L + Q E ++ E
Sbjct: 856 EEEMQAKDEELQRTKERQ-QKAEAELKELEQKHTQLCEEKNLLQEKLQAETELYAEAEEM 914
Query: 186 LNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQK 245
+ + L++ E E ++E +E QL+A+K + + Q L+ LE L ++
Sbjct: 915 RVRLAAKKQELEEILHEMEARIEEEEERSQQLQAEK---KKMQQQMLD----LEEQLEEE 967
Query: 246 DNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELE 305
EA K +L +V KI +E+ I + E+ + L + + E
Sbjct: 968 ---EAARQKLQLEKVTADG------------KIKKMEDDILIMEDQNNKLTKERKLLEER 1012
Query: 306 VETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEIS 365
V L NLAE E+ +L+ L + IS++E + +++ ++L+ KI+++ E E S
Sbjct: 1013 VSDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE-KIKRKLEG-ESS 1070
Query: 366 EKHRGMLEKSNQNLQLEA------ENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFI 419
+ H + E Q +L+A E L +A + E +K+ +++++ L S+
Sbjct: 1071 DLHEQIAELQAQIAELKAQLAKKEEELQAALARLEDETSQKNNALKKIREL----ESHIS 1126
Query: 420 QIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD----------LELSKQDFKEEMQG 469
++ L++ + ++++K++R+L+ EL+ L+D L ++ ++
Sbjct: 1127 DLQEDLESEKAARNKAEKQKRDLSEELEALKTELEDTLDTTATQQELRAKREQEVTVLKR 1186
Query: 470 IVEENKTLHELNFSSTRSLKKQQME-----ISKLKEIKEKLEREFHTSTEESNVLQRETH 524
+EE HE R Q +E + + K K L++ T +++ L E
Sbjct: 1187 ALEEETRTHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKTKQTLEKDNADLANEIR 1246
Query: 525 ---QIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEA 581
Q K D++H ++ + L+ LQS S VR NE K H +
Sbjct: 1247 SLSQAKQDVEHKKKKLEVQLQDLQS----KYSDGERVRTELNE---------KVHKLQIE 1293
Query: 582 LREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTL 641
+ + +NE +N + + L +L + ++E + + + L D+K++L
Sbjct: 1294 VENVTSLLNEAESKNIKLTKDVATLGSQLQDTQELLQEETRQKLNVTTKLRQLEDDKNSL 1353
Query: 642 LSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNER 701
QL E+ Q + + + L LSD+K + + + + + + K LQ E
Sbjct: 1354 QEQLDEEVEAKQNLERHISTLTIQLSDSKKKLQ-------EFTATVETMEEGKKKLQREI 1406
Query: 702 SMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL------FASILVQKE 755
L Q E LEK L+++ D+ D ++ V L F +L +++
Sbjct: 1407 ESLTQQFEEKAASYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQMLAEEK 1466
Query: 756 NHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELEL 815
N S+ K++ E A E E+ + + L+ + A+ EELE
Sbjct: 1467 NISS-KYADERDRAEAE------AREKETKALSLARALEEALEAK----------EELER 1509
Query: 816 KNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQI 875
N +L E E LV + K + ELE + L ++ + K + ++ LQ
Sbjct: 1510 TNKMLKAEMEDLVSSKDDVGKNVHELEKS-------KRTLEQQVEEMKTQLEELEDELQA 1562
Query: 876 DSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGE 935
D E+ + + E L E+N++ + LL L +H++E E
Sbjct: 1563 AEDAKLRLEVNMQAMK--------SQFERDLQARDEQNEE---KRRQLLKQLHEHETELE 1611
Query: 936 KLKLE-------KKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV------------ 976
+ + KK +E + +++ Q K + E +++ R+L+ ++
Sbjct: 1612 DERKQRALAAAAKKKLEVDVKDLESQVDSANKAREEAIKQLRKLQAQMKDYQRDLDDARA 1671
Query: 977 ----VNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAK 1032
+ +EN K+ L+AE+I+L++ + + EK + ++ +
Sbjct: 1672 AREEIFATARENEKKAK--NLEAELIQLQEDLAAAERARKQADLEKEEMAEELASANSGR 1729
Query: 1033 SSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLR 1092
+S +DE + + L L E E M ++ + + + LNN+L E +
Sbjct: 1730 TSLQDEKRRLEARIAQLEE-ELDEEHSNIETMSDR--MRKAVQQAEQLNNELATERATAQ 1786
Query: 1093 KNFEVKEAENVYLNESIERMDKE----LLEMDKRLK--------AAETSNAEFSRHIEEL 1140
KN EN + +ER +KE L EM+ +K A E A +E+
Sbjct: 1787 KN------ENA--RQQLERQNKELRSKLQEMEGAVKSKFKSTIAALEAKIASLEEQLEQE 1838
Query: 1141 KMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVRE 1200
E++ + K D+++ + + +K+ E + E +K L ++E+
Sbjct: 1839 AREKQAAAKTLRQKDKKLKDALLQVEDERKQAEQYKDQAEKGNLRLKQLKRQLEEAEEES 1898
Query: 1201 EALN 1204
+ +N
Sbjct: 1899 QRIN 1902
Score = 136 bits (342), Expect = 6e-31
Identities = 224/1201 (18%), Positives = 489/1201 (40%), Gaps = 144/1201 (11%)
Query: 279 PMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKME 338
P+L+ + EE + +++++RT+ + L E+ ++ L + EK+
Sbjct: 848 PLLQ--VTRQEEEMQAKDEELQRTKERQQKAEAELKELEQKHTQLCEEKNLLQEKLQAET 905
Query: 339 NEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELL 398
+E +L K ++ E L E E+ +Q LQ E + + Q++ + +L
Sbjct: 906 ELYAEAEEMRVRLAAKKQELEEILHEMEARIEEEEERSQQLQAEKKKMQQQMLDLEEQLE 965
Query: 399 EKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLEL 458
E+ ++LQ ++E + ++ ++ KE++ L + DL
Sbjct: 966 EEEAARQKLQLEKVTADGKIKKMEDDILIMEDQNNKLTKERKLLEERVS-------DLTT 1018
Query: 459 SKQDFKEEMQGIVEENKTLHELNFSSTR-SLKKQQMEISKLKEIKEKLEREFHTSTEESN 517
+ + +E+ + + + K HE S LKK++ +L++IK KLE E E+
Sbjct: 1019 NLAEEEEKAKNLTKL-KNKHESMISELEVRLKKEEKSRQELEKIKRKLEGESSDLHEQIA 1077
Query: 518 VLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHS 577
LQ + ++K + E QA L +L+ N+ +R+L++ L+E + E +
Sbjct: 1078 ELQAQIAELKAQLAKKEEELQAALARLEDETSQKNNALKKIRELESHISDLQEDLESEKA 1137
Query: 578 EKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADE 637
+ ++ +D++E L L EL+ T Q+ ++E ++L
Sbjct: 1138 ARNKAEKQKRDLSE----------ELEALKTELEDTLDTTATQQELRAKREQEVTVL--- 1184
Query: 638 KSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNL 697
K L + + +Q++ + +T + L++ + E + +L+ + L + +L
Sbjct: 1185 KRALEEETRTHEAQVQEMRQKHTQAVEELTE---QLEQFKRAKANLDKTKQTLEKDNADL 1241
Query: 698 QNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENH 757
NE L + VE K LE ++ +L+ KY+D E+ + ++ E + ++ EN
Sbjct: 1242 ANEIRSLSQAKQDVEHKKKKLEVQLQDLQSKYSDGERVR----TELNEKVHKLQIEVENV 1297
Query: 758 SNHKHSSEARLANLENIVRV----LQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEEL 813
++ + +E++ L V LQ+ Q L + E Q+L+ + + +L
Sbjct: 1298 TSLLNEAESKNIKLTKDVATLGSQLQDTQELLQEETRQKLN-----------VTTKLRQL 1346
Query: 814 ELKNFVLLTECEKLVEASKFSDKVISELE---SENLMQLIEEEFLLHRIRKFKMDIHKVC 870
E L + ++ VEA + ++ IS L S++ +L E + + + K + +
Sbjct: 1347 EDDKNSLQEQLDEEVEAKQNLERHISTLTIQLSDSKKKLQEFTATVETMEEGKKKLQREI 1406
Query: 871 GVL--QIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQ 928
L Q + ++++K + +R+ +++ L L +NQ+ LV N L+
Sbjct: 1407 ESLTQQFEEKAASYDKLEKTK---NRLQQELDDLVVDL-----DNQRQLVSN------LE 1452
Query: 929 QHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKS 988
+ Q + +++ E+K + ++ + ++D+ E EKE ++ S
Sbjct: 1453 KKQKKFDQMLAEEKNISSKYAD--------ERDRAE------------AEAREKETKALS 1492
Query: 989 TLAALQAEM---IELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHD 1045
AL+ + EL +TN++ + E ++ K+ + +NV +L+ +K + E +
Sbjct: 1493 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRTLEQQ------- 1545
Query: 1046 VLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYL 1105
+ + E E + A N+ + + ++ L+ E E + L
Sbjct: 1546 ---VEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQFERD---LQARDEQNEEKRRQL 1599
Query: 1106 NESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENC 1165
+ + + EL + K+ A + + +++L+ + + + K +E +Q+
Sbjct: 1600 LKQLHEHETELEDERKQRALAAAAKKKLEVDVKDLESQVDSANKAREEAIKQL------- 1652
Query: 1166 MNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFY 1225
LQ +MK +++ R E + E + K E E
Sbjct: 1653 --------------RKLQAQMKDYQRDLDDARAAREEIFATARENEKKAKNLEAELIQLQ 1698
Query: 1226 HDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLS 1285
DL + + + E+ ++ S SL++E R LE+ I L+E+L
Sbjct: 1699 EDLAAAERARKQADLEKEEMAE--ELASANSGRTSLQDEKRR-----LEARIAQLEEELD 1751
Query: 1286 AYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQ---SARENEI 1342
+ ++ + + + AQK+ L + + + +E E
Sbjct: 1752 EEHSNIETMSDRMRKAVQQAEQLNNELATERATAQKNENARQQLERQNKELRSKLQEMEG 1811
Query: 1343 VLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKK 1402
+ S + L+ +I ++E+ + +E R KQ + T L+ A +VE+ +K
Sbjct: 1812 AVKSKFKSTIAALEAKIASLEEQLEQE--AREKQAAAKTLRQKDKKLKDALL-QVEDERK 1868
Query: 1403 EIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENN 1462
+ E ++ + K L +K + ++ S+ + R+ + E E+N
Sbjct: 1869 QAEQYKD---------QAEKGNLRLKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1919
Query: 1463 E 1463
+
Sbjct: 1920 D 1920
Score = 123 bits (309), Expect = 4e-27
Identities = 234/1152 (20%), Positives = 464/1152 (39%), Gaps = 146/1152 (12%)
Query: 535 ERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
E QA E+LQ A +++L+ ++ L E EK L+EK + E+
Sbjct: 857 EEMQAKDEELQRTKERQQKAEAELKELEQKHTQLCE-------EKNLLQEKLQAETELYA 909
Query: 595 ENACMEFSLLGLNDELDGL----RGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
E M L EL+ + ++E ++ Q LQ EK + + L QL+
Sbjct: 910 EAEEMRVRLAAKKQELEEILHEMEARIEEEEERSQQLQAEKKKMQQQMLDLEEQLEEEEA 969
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSML------ 704
+ QK+ LEK +D KI+ +ED ++ D+ N L ER +L
Sbjct: 970 ARQKLQ-----LEKVTADGKIK---------KMEDDILIMEDQNNKLTKERKLLEERVSD 1015
Query: 705 -ISQLEIVEEKLSNLEKKVTNLEEKYADVE---KDKESAVNQVEELFASILVQKENHSNH 760
+ L EEK NL K E +++E K +E + ++E++ + + E+ H
Sbjct: 1016 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKIKRKL--EGESSDLH 1073
Query: 761 KHSSE--ARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNF 818
+ +E A++A L+ + +EE + E E + NA ++ L++ I +L+
Sbjct: 1074 EQIAELQAQIAELKAQLAKKEEELQAALARLEDETSQKNNALKKIRELESHISDLQED-- 1131
Query: 819 VLLTECEKLV--EASKFSDKVISELES-----ENLMQLIEEEFLLHRIRKFKMDIHKVCG 871
E EK +A K + ELE+ E+ + + L R+ ++ + K
Sbjct: 1132 ---LESEKAARNKAEKQKRDLSEELEALKTELEDTLDTTATQQELRAKREQEVTVLKRAL 1188
Query: 872 VLQIDSDGGGDNEIKKEEIP-ISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQH 930
+ + E++++ + + +++E + + + Q L +N+ L ++
Sbjct: 1189 EEETRTHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKTKQTLEKDNADLANEIRSL 1248
Query: 931 QSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTL 990
+ ++ +KK +E + ++++ + ++ + EL E+ +L+IEV N N ++S
Sbjct: 1249 SQAKQDVEHKKKKLEVQLQDLQSKYSDGERVRTELNEKVHKLQIEVENVTSLLNEAESKN 1308
Query: 991 AALQAEMI----ELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDV 1046
L ++ +L+ T ++ QEE + L+ L L+D K+S +++ + +V
Sbjct: 1309 IKLTKDVATLGSQLQDTQELLQEETRQKLNVTTKL----RQLEDDKNSLQEQ---LDEEV 1361
Query: 1047 LALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNND---LNQEFGVLRKNFEVKEAENV 1103
A NL + K+ L E + + L +E L + FE K A
Sbjct: 1362 EAKQNLERHISTLTIQLSDSKKKLQEFTATVETMEEGKKKLQREIESLTQQFEEKAASYD 1421
Query: 1104 YLNESIERMDKEL----LEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDR--- 1156
L ++ R+ +EL +++D + + + + + L E+ S+K + DR
Sbjct: 1422 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQMLAEEKNISSKYADERDRAEA 1481
Query: 1157 QILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKL 1216
+ E+ ++ + +E EA E L+ K L E+E +L++ +++
Sbjct: 1482 EAREKETKALSLARALEEALEAKEELERTNKMLKAEME-----------DLVSSKDD--- 1527
Query: 1217 WENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDE----SSAKSLENEHMREIISL 1272
H+L+ S LE +V E+ + L+DE AK +M+ + S
Sbjct: 1528 ----VGKNVHELEKSK---RTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQ 1580
Query: 1273 LESEIGGLKEQLSAYV-PLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRK 1331
E ++ EQ L+ L E LE ++ + A+K + ++ +
Sbjct: 1581 FERDLQARDEQNEEKRRQLLKQLHEHETELED-----ERKQRALAAAAKKKLEVDVKDLE 1635
Query: 1332 HSHQSARENEIVLIPDGVSDLLTLQTRIR-----------AVEKIMMEELKRRVKQKSLT 1380
SA + + + L LQ +++ A E+I + K K+L
Sbjct: 1636 SQVDSANKAR----EEAIKQLRKLQAQMKDYQRDLDDARAAREEIFATARENEKKAKNLE 1691
Query: 1381 TESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWR---KKPKIRLLMKDIPLDRNVD 1437
E A + E E + E + NS R + K RL + L+ +D
Sbjct: 1692 AELIQLQEDLAAAERARKQADLEKEEMAEELASANSGRTSLQDEKRRLEARIAQLEEELD 1751
Query: 1438 DQNS----------KYLKREHRRTNDHVLE--LCENNEHEPLSAPTVDHAMICHRSDDSG 1485
+++S K +++ + N+ E + NE+ + + + G
Sbjct: 1752 EEHSNIETMSDRMRKAVQQAEQLNNELATERATAQKNENARQQLERQNKELRSKLQEMEG 1811
Query: 1486 RYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKK 1545
+ E + LE E+ +K+ + L +KL + ++D +K
Sbjct: 1812 AVKSKFKSTIAALEAKIASLE---EQLEQEAREKQAAAKTLRQKDKKLKDALLQVEDERK 1868
Query: 1546 KTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASS---LDREIP- 1601
+ E K + ++ + +KR +EE EE + + ++ + ++E S L RE+
Sbjct: 1869 QAEQYKDQAEKGNLRLKQLKRQLEEAEEESQRINANRRKLQRELDEATESNDALGREVAA 1928
Query: 1602 -----RRGSEQI 1608
RRG+E +
Sbjct: 1929 LKSKLRRGNEPV 1940
Score = 96.3 bits (238), Expect = 6e-19
Identities = 217/1092 (19%), Positives = 427/1092 (38%), Gaps = 143/1092 (13%)
Query: 593 LMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESM 652
L++ E + ++EL + ++ + + L+++ + L +EK+ L +LQ TE
Sbjct: 849 LLQVTRQEEEMQAKDEELQRTKERQQKAEAELKELEQKHTQLCEEKNLLQEKLQAETELY 908
Query: 653 QKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVE 712
+ E L + + + + + E+ + L EK +Q + L QLE E
Sbjct: 909 AEAEEMRVRLAAKKQELEEILHEMEARIEEEEERSQQLQAEKKKMQQQMLDLEEQLEEEE 968
Query: 713 EKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN-- 770
L+ + + K +E D IL+ ++ N+K + E +L
Sbjct: 969 AARQKLQLEKVTADGKIKKMEDD--------------ILIMEDQ--NNKLTKERKLLEER 1012
Query: 771 LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEA 830
+ ++ L EE+ K L ++ N M I ELE++ L E + E
Sbjct: 1013 VSDLTTNLAEEEEKAK-----NLTKLKNKHESM------ISELEVR---LKKEEKSRQEL 1058
Query: 831 SKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQI------DSDGGGDNE 884
K K+ E ES +L + I E L +I + K + K LQ D +N
Sbjct: 1059 EKIKRKL--EGESSDLHEQIAE--LQAQIAELKAQLAKKEEELQAALARLEDETSQKNNA 1114
Query: 885 IKKEEIPISRILDKIESLESSLV---KSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEK 941
+KK S I D E LES K++++ + L E L L+ L+
Sbjct: 1115 LKKIRELESHISDLQEDLESEKAARNKAEKQKRDLSEELEALKTELED--------TLDT 1166
Query: 942 KTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQ-AEMIE- 999
+QE REQ V + K +E EE R +V +E R K T A + E +E
Sbjct: 1167 TATQQELRAKREQEVTVLKRALE--EETRTHEAQV-----QEMRQKHTQAVEELTEQLEQ 1219
Query: 1000 -------LRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNL 1052
L +T Q +++N + +E SL + D++ K E + L +L
Sbjct: 1220 FKRAKANLDKTKQTLEKDNADLANEIRSLSQAKQDVEHKKKKLE----------VQLQDL 1269
Query: 1053 NLVY---EIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESI 1109
Y E TE + L + N++ L N+ + L K+ ++ E +
Sbjct: 1270 QSKYSDGERVRTELNEKVHKLQIEVENVTSLLNEAESKNIKLTKDVATLGSQLQDTQELL 1329
Query: 1110 ERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHK 1169
+ ++ L + +L+ E L+ + +E + K+NL+R I + + K
Sbjct: 1330 QEETRQKLNVTTKLRQLEDDK-------NSLQEQLDEEVEAKQNLERHISTLTIQLSDSK 1382
Query: 1170 KEIEHLNEANETLQFEMKTLLHEVEQ--HRVREEALNLELLNKENEFKLWENEAAAFYHD 1227
K+++ ET++ K L E+E + E+A + + L K + E D
Sbjct: 1383 KKLQEFTATVETMEEGKKKLQREIESLTQQFEEKAASYDKLEKTKN--RLQQELDDLVVD 1440
Query: 1228 LQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAY 1287
L ++ LE K + + + ++++ + +E R E E L
Sbjct: 1441 LDNQRQLVSNLEKKQKKFDQM--LAEEKNISSKYADERDRAEAEAREKETKALS------ 1492
Query: 1288 VPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIV--LI 1345
L +L+E + E + + N ++ + V + + K+ H+ + + +
Sbjct: 1493 --LARALEEALEAKEELE----RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRTLEQQV 1546
Query: 1346 PDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIE 1405
+ + L L+ ++A E + K R++ +S L+ E R++ ++
Sbjct: 1547 EEMKTQLEELEDELQAAE-----DAKLRLEVNMQAMKSQFERDLQARDEQNEEKRRQLLK 1601
Query: 1406 LVEENVFDRNSWRK--------KPKIRLLMKDIPLDRNVDDQNS------KYLKREHRRT 1451
+ E+ + RK K K+ + +KD L+ VD N K L++ +
Sbjct: 1602 QLHEHETELEDERKQRALAAAAKKKLEVDVKD--LESQVDSANKAREEAIKQLRKLQAQM 1659
Query: 1452 NDHVLELCENNE-HEPLSAPTVDH--------AMICHRSDDSGRYLNYSSELDIEKELGV 1502
D+ +L + E + A ++ A + +D + D+EKE
Sbjct: 1660 KDYQRDLDDARAAREEIFATARENEKKAKNLEAELIQLQEDLAAAERARKQADLEKEEMA 1719
Query: 1503 DKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYE 1562
++L + S + +D+KRR+ R++ ++L ++ + + + + + E
Sbjct: 1720 EELASANSGRTSLQDEKRRLEARIAQLEEELDEEHSNIETMSDRMRKAVQQAEQLNNELA 1779
Query: 1563 TVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYIL 1622
T + ++ E A Q N ++ ++E ++ + + I L+ ++ +++ L
Sbjct: 1780 TERATAQKNENARQQLERQNKELRSKLQE----MEGAVKSKFKSTIAALEAKIASLEEQL 1835
Query: 1623 LKLAEENNNKVK 1634
+ A E K
Sbjct: 1836 EQEAREKQAAAK 1847
Score = 91.3 bits (225), Expect = 2e-17
Identities = 128/633 (20%), Positives = 271/633 (42%), Gaps = 83/633 (13%)
Query: 126 ESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETD 185
E H S T + +++ +E V+T+ E K+Q + ++L Q++E + K+E
Sbjct: 1368 ERHISTL-TIQLSDSKKKLQEFTATVETMEEGKKKLQREIESLTQQFEEKAASYDKLEKT 1426
Query: 186 LNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQK 245
N+ Q LDD L D D L + + + + ML+++
Sbjct: 1427 KNRLQQE---LDD------------------LVVDLDNQRQLVSNLEKKQKKFDQMLAEE 1465
Query: 246 DNIEAK--NLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTE 303
NI +K + + +K+T L + LE+ LE K L E ++ML ++E
Sbjct: 1466 KNISSKYADERDRAEAEAREKETKALSLARALEE--ALEAKEEL-ERTNKMLKAEMEDLV 1522
Query: 304 LEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEI-------LHVQENAEQLKNKIE 356
+ + KN+ E+ + + +L ++ ++E+E+ L ++ N + +K++ E
Sbjct: 1523 SSKDDVGKNVHELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQFE 1582
Query: 357 K--EAEKLEISEKHRGMLEKSNQN-LQLEAENLVQRIASKDHELLEKHTEIERLQTLMHG 413
+ +A + EK R +L++ +++ +LE E + +A+ + LE +++ L++ +
Sbjct: 1583 RDLQARDEQNEEKRRQLLKQLHEHETELEDERKQRALAAAAKKKLE--VDVKDLESQVDS 1640
Query: 414 EHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEE 473
+ E A++ L+KL +Q + QR +L +++ + ++ +++ + + E
Sbjct: 1641 ANK---AREEAIKQLRKLQAQMKDYQR----DLDDARAAREEIFATARENEKKAKNLEAE 1693
Query: 474 NKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHL 533
L E ++ R+ K+ +E KE++ E ++ LQ E +++ I L
Sbjct: 1694 LIQLQEDLAAAERARKQADLE-------KEEMAEELASANSGRTSLQDEKRRLEARIAQL 1746
Query: 534 NERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVL 593
E ++++ L NE + T +K + ++ L ++K++ L
Sbjct: 1747 EEELDEEHSNIETMSDRMRKAVQQAEQLNNELATERATAQKNENARQQLERQNKELRSKL 1806
Query: 594 MENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQ 653
E ME ++ + T+ ++ L+E+ A EK L+ Q
Sbjct: 1807 QE---MEGAV------KSKFKSTIAALEAKIASLEEQLEQEAREKQAAAKTLR------Q 1851
Query: 654 KILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEE 713
K +K L DA ++ E R ++ +D EK NL+ ++ L QLE EE
Sbjct: 1852 K--------DKKLKDALLQVEDERKQAEQYKD-----QAEKGNLRLKQ--LKRQLEEAEE 1896
Query: 714 KLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL 746
+ + L+ + + + ++ +V L
Sbjct: 1897 ESQRINANRRKLQRELDEATESNDALGREVAAL 1929
Score = 84.3 bits (207), Expect = 2e-15
Identities = 102/527 (19%), Positives = 221/527 (41%), Gaps = 47/527 (8%)
Query: 25 NSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAE 84
N + L+ NL + K K +++ EE + ++ A+ + E + + RAL E
Sbjct: 1443 NQRQLVSNL---EKKQKKFDQMLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1499
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
+ A EL +K + + S +G + ++ T + E +
Sbjct: 1500 ALE-AKEELERTNKMLKAEMEDLV-------SSKDDVGKNVHELEKSKRTLEQQVEEMKT 1551
Query: 145 --EESNGEVQTLREALAKMQSDKDALFLQYQESLE-----NLSKMETDLNKAQNNARGLD 197
EE E+Q +A +++ + A+ Q++ L+ N K L + + L+
Sbjct: 1552 QLEELEDELQAAEDAKLRLEVNMQAMKSQFERDLQARDEQNEEKRRQLLKQLHEHETELE 1611
Query: 198 DRASEAEIQVEILKE---SLMQLKADKDAGEVLYNQCLETIARLESMLS--QKDNIEAKN 252
D + + K+ + L++ D+ + ++ + +L++ + Q+D +A+
Sbjct: 1612 DERKQRALAAAAKKKLEVDVKDLESQVDSANKAREEAIKQLRKLQAQMKDYQRDLDDARA 1671
Query: 253 LKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKN 312
++E+ + + +K LE ++ +E+ ++ +LE E + +
Sbjct: 1672 AREEIFATARENE----------KKAKNLEAELIQLQEDLAAAERARKQADLEKEEMAEE 1721
Query: 313 LAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGML 372
LA N R SL +I+++E E+ N E + +++ K ++ E
Sbjct: 1722 LASANSGRTSLQDEKRRLEARIAQLEEELDEEHSNIETMSDRMRKAVQQAEQLNNELATE 1781
Query: 373 EKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLY 432
+ Q + EN Q++ ++ EL K E+E + S +E+ + +L++
Sbjct: 1782 RATAQ----KNENARQQLERQNKELRSKLQEMEG--AVKSKFKSTIAALEAKIASLEEQL 1835
Query: 433 SQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEE----NKTLHELNFSSTRSL 488
Q +E++ A L+ LKD L +D +++ + ++ N L +L R L
Sbjct: 1836 EQEAREKQAAAKTLRQKDKKLKDALLQVEDERKQAEQYKDQAEKGNLRLKQLK----RQL 1891
Query: 489 KKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNE 535
++ + E ++ + KL+RE +TE ++ L RE +K ++ NE
Sbjct: 1892 EEAEEESQRINANRRKLQRELDEATESNDALGREVAALKSKLRRGNE 1938
Score = 82.0 bits (201), Expect = 1e-14
Identities = 155/829 (18%), Positives = 334/829 (39%), Gaps = 122/829 (14%)
Query: 35 DIDTKVKSMIKLIEEEADSFARRAEMYYKKRPE---LMKLVEEFYRAYRALAERYDHAMG 91
D+ +++++ +E+ D+ A + E+ K+ E L + +EE R + A +
Sbjct: 1148 DLSEELEALKTELEDTLDTTATQQELRAKREQEVTVLKRALEEETRTHEAQVQ------- 1200
Query: 92 ELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKN--ERSSEESNG 149
E+R H E L E A+ K E+ + +
Sbjct: 1201 EMRQKHTQAVE-----------------ELTEQLEQFKRAKANLDKTKQTLEKDNADLAN 1243
Query: 150 EVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEI 209
E+++L +A ++ K L +Q Q+ +++ + + L+++ + +I+VE
Sbjct: 1244 EIRSLSQAKQDVEHKKKKLEVQLQD-------LQSKYSDGERVRTELNEKVHKLQIEVEN 1296
Query: 210 LKESLMQ-----LKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQK 264
+ L + +K KD L +Q +T L+ QK N+ K L ++ K
Sbjct: 1297 VTSLLNEAESKNIKLTKDVA-TLGSQLQDTQELLQEETRQKLNVTTK-----LRQLEDDK 1350
Query: 265 DTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLS 324
+++ Q + +E LE I+ +++ VET+ + ++ E +SL+
Sbjct: 1351 NSLQEQLDEEVEAKQNLERHISTLTIQLSDSKKKLQEFTATVETMEEGKKKLQREIESLT 1410
Query: 325 VLYHHCLEKISKMENEILHVQ----------ENAEQLKNKIEKE--------AEKLEISE 366
+ K+E +Q +N QL + +EK+ AE+ IS
Sbjct: 1411 QQFEEKAASYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQMLAEEKNISS 1470
Query: 367 KHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQ 426
K+ +++ + E E +A E LE E+ER ++ E + + S+
Sbjct: 1471 KYADERDRAEAEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV---SSKD 1526
Query: 427 ALQKLYSQSQKEQRNL---ALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHE--LN 481
+ K + +K +R L E+K L L+D + +D K ++ ++ K+ E L
Sbjct: 1527 DVGKNVHELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQFERDLQ 1586
Query: 482 FSSTRSLKKQQMEISKLKEIKEKLE---REFHTSTEESNVLQRETHQIKDDIQHLNERYQ 538
++ +K++ + +L E + +LE ++ + L+ + ++ + N+ +
Sbjct: 1587 ARDEQNEEKRRQLLKQLHEHETELEDERKQRALAAAAKKKLEVDVKDLESQVDSANKARE 1646
Query: 539 AMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENAC 598
++QL+ L + + D + + T ++ +EK+A
Sbjct: 1647 EAIKQLRKLQAQMKDYQRDLDDARAAREEIFATARE--NEKKAKN--------------- 1689
Query: 599 MEFSLLGLNDELDGLRGTVKEIQQFCQVLQEE-------KSILADEKSTLLSQLQIITES 651
+E L+ L ++L K+ + + EE ++ L DEK L +++ + E
Sbjct: 1690 LEAELIQLQEDLAAAERARKQADLEKEEMAEELASANSGRTSLQDEKRRLEARIAQLEEE 1749
Query: 652 MQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIV 711
+ + N + + A + E L + + + + L+ + L S+L+ +
Sbjct: 1750 LDEEHSNIETMSDRMRKAVQQAEQLNNELATERATAQKNENARQQLERQNKELRSKLQEM 1809
Query: 712 E--------EKLSNLEKKVTNLEEKYADVEKDKESA---VNQVEELFASILVQKENH--- 757
E ++ LE K+ +LEE+ ++K++A + Q ++ L+Q E+
Sbjct: 1810 EGAVKSKFKSTIAALEAKIASLEEQLEQEAREKQAAAKTLRQKDKKLKDALLQVEDERKQ 1869
Query: 758 -SNHKHSSEARLANLENIVRVL----QEEQRL--GKVEFEQELDRVVNA 799
+K +E L+ + R L +E QR+ + + ++ELD +
Sbjct: 1870 AEQYKDQAEKGNLRLKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1918
Score = 81.3 bits (199), Expect = 2e-14
Identities = 174/840 (20%), Positives = 341/840 (39%), Gaps = 133/840 (15%)
Query: 894 RILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMRE 953
R+ K++ L V QEE Q E LQ+ + +K + E K +EQ+ + E
Sbjct: 841 RLFTKVKPLLQ--VTRQEEEMQAKDEE------LQRTKERQQKAEAELKELEQKHTQLCE 892
Query: 954 QNVILQKD---KVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEE 1010
+ +LQ+ + EL E ++R+ + K+ + L ++A + E + +Q Q E
Sbjct: 893 EKNLLQEKLQAETELYAEAEEMRVRLA---AKKQELEEILHEMEARIEEEEERSQQLQAE 949
Query: 1011 NGKMLDEKNSLCRNVSDLKDA-------KSSAEDENSVMFHDVLALSNLNLVYEIFFTEN 1063
KM + L + + + A K +A+ + M D+L + + N
Sbjct: 950 KKKMQQQMLDLEEQLEEEEAARQKLQLEKVTADGKIKKMEDDILIMEDQN--------NK 1001
Query: 1064 MVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKEL-----LE 1118
+ ++R L E +S L +L +E + ++K ++E R+ KE LE
Sbjct: 1002 LTKERKLLEE--RVSDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1059
Query: 1119 MDKRLKAAETSN-----AEFSRHIEELKME----QEESTKIKENLDRQILEQSENCMNHK 1169
KR E+S+ AE I ELK + +EE L+ + Q N +
Sbjct: 1060 KIKRKLEGESSDLHEQIAELQAQIAELKAQLAKKEEELQAALARLEDET-SQKNNALKKI 1118
Query: 1170 KEIE-HLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDL 1228
+E+E H+++ E L+ E K ++ E+ + R+ + LE L E E L + A +L
Sbjct: 1119 RELESHISDLQEDLESE-KAARNKAEKQK-RDLSEELEALKTELEDTL---DTTATQQEL 1173
Query: 1229 QMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYV 1288
+ + E+T + + L++E+ + + MR+ + E L EQL +
Sbjct: 1174 RAK---------REQEVTVLKRALEEETRTHEAQVQEMRQKHTQAVEE---LTEQLEQFK 1221
Query: 1289 PLVSSLKEDFNSLE--------HISLLWTKRNSVVGNGAQKDVVIETCLRKHSH------ 1334
++L + +LE I L + V + +V ++ K+S
Sbjct: 1222 RAKANLDKTKQTLEKDNADLANEIRSLSQAKQDVEHKKKKLEVQLQDLQSKYSDGERVRT 1281
Query: 1335 ---------QSARENEIVLIPDGVS-------DLLTLQTRIRAVEKIMMEELKRRVK--- 1375
Q EN L+ + S D+ TL ++++ ++++ EE ++++
Sbjct: 1282 ELNEKVHKLQIEVENVTSLLNEAESKNIKLTKDVATLGSQLQDTQELLQEETRQKLNVTT 1341
Query: 1376 ------------QKSLTTESTPYSSLE--IATYP-KVENRKKEIELVEENVFDRNSWRKK 1420
Q+ L E +LE I+T ++ + KK+++ V +KK
Sbjct: 1342 KLRQLEDDKNSLQEQLDEEVEAKQNLERHISTLTIQLSDSKKKLQEFTATVETMEEGKKK 1401
Query: 1421 --PKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHA--- 1475
+I L + D+ K R + +D V++L +N+ + +S
Sbjct: 1402 LQREIESLTQQFEEKAASYDKLEKTKNRLQQELDDLVVDL--DNQRQLVSNLEKKQKKFD 1459
Query: 1476 -MICHRSDDSGRYLNYSSELDIE-KELGVDKLELSKSVKEKTE--DDKRRILERLSSDGQ 1531
M+ + S +Y + + E +E L L+++++E E ++ R + L ++ +
Sbjct: 1460 QMLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1519
Query: 1532 KLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEE 1591
L K D+ K +KSK+ + + E +K +EE+E+ + ++ N++
Sbjct: 1520 DLVSSK---DDVGKNVHELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQA 1576
Query: 1592 GASSLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISRKTGILLRRKLRV 1651
S +R++ R + K + +L +L E R R ++KL V
Sbjct: 1577 MKSQFERDLQARDEQNEEKR-------RQLLKQLHEHETELEDERKQRALAAAAKKKLEV 1629
Score = 74.7 bits (182), Expect = 2e-12
Identities = 106/578 (18%), Positives = 239/578 (41%), Gaps = 53/578 (9%)
Query: 31 ENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALA------E 84
E + +++S+ + EE+A S+ + + + + EL LV + + ++ +
Sbjct: 1397 EGKKKLQREIESLTQQFEEKAASYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQK 1456
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
++D + E ++ +S Y D + + + ++ + AR + + +
Sbjct: 1457 KFDQMLAEEKNI---------SSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1507
Query: 145 EESNGEVQTLREALAKMQSDKDALFLQYQESLENLSK----METDLNKAQNNARGLDDRA 200
E +N ++ E L + D + ++S L + M+T L + ++ + +D
Sbjct: 1508 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAK 1567
Query: 201 SEAEIQVEILKESLMQ-LKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTR 259
E+ ++ +K + L+A + E Q L+ + E+ L + A +
Sbjct: 1568 LRLEVNMQAMKSQFERDLQARDEQNEEKRRQLLKQLHEHETELEDERKQRALAAAAKKKL 1627
Query: 260 VVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEE 319
V KD LE+++ A + Q+ + + +++ +++L +
Sbjct: 1628 EVDVKD---------------LESQVDSANKAREEAIKQLRKLQAQMKDYQRDLDDARAA 1672
Query: 320 RDSLSVLYHHCLEKISKMENEILHVQEN---AEQLKNKIEKEAEKL--EISEKHRGMLEK 374
R+ + +K +E E++ +QE+ AE+ + + + E E++ E++ + G
Sbjct: 1673 REEIFATARENEKKAKNLEAELIQLQEDLAAAERARKQADLEKEEMAEELASANSGRTSL 1732
Query: 375 SNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQ 434
++ +LEA RIA + EL E+H+ IE + M Q+ + L + +
Sbjct: 1733 QDEKRRLEA-----RIAQLEEELDEEHSNIETMSDRMRKAVQQAEQLNNELATERATAQK 1787
Query: 435 SQKEQRNLALELKYGLLLLKDLELS-KQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQM 493
++ ++ L + K L+++E + K FK + + + +L E + +++Q
Sbjct: 1788 NENARQQLERQNKELRSKLQEMEGAVKSKFKSTIAALEAKIASLEE---QLEQEAREKQA 1844
Query: 494 EISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNS 553
L++ +KL+ +E +++ Q KD + N R + + QL+
Sbjct: 1845 AAKTLRQKDKKLKDALLQVEDE----RKQAEQYKDQAEKGNLRLKQLKRQLEEAEEESQR 1900
Query: 554 FAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNE 591
A+ R LQ E E+ E AL+ K + NE
Sbjct: 1901 INANRRKLQRELDEATESNDALGREVAALKSKLRRGNE 1938
>MLP1_YEAST (Q02455) MLP1 protein (Myosin-like protein 1)
Length = 1875
Score = 157 bits (396), Expect = 3e-37
Identities = 355/1701 (20%), Positives = 698/1701 (40%), Gaps = 235/1701 (13%)
Query: 31 ENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAM 90
E++ + K+ S ++ ++ + D + + +K+++E + + + +
Sbjct: 107 ESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSN 166
Query: 91 GELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTH-------RSKKNERS 143
E + T+ + YI ND + L + T + + RSK +
Sbjct: 167 SECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYL 226
Query: 144 S--EESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNA----RGLD 197
S ++++ + +R L ++++D F + + + L + +L+K+ +GL
Sbjct: 227 SYRQKTDKVILDIRNELNRLRND----FQMERTNNDVLKQKNNELSKSLQEKLLEIKGLS 282
Query: 198 D--RASEAEIQVEI-LKESLMQL-KADKDAGEVLYNQCLE-TIARLESMLSQKDNIEAKN 252
D + + E E+ LK+ L+ L ++ +A + N E A++ + S+K E ++
Sbjct: 283 DSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENED 342
Query: 253 LKQELTRVVVQKDTVLLQYKQCLEKIPML-------ENKIALAEENSRMLNDQIERTELE 305
L +EL + K+ + K+CL + EN A + + L Q+ +
Sbjct: 343 LLKELQ---LTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRT 399
Query: 306 VETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEIS 365
E L+ + E + + + E+ +ENE+ + E N EK A+ E++
Sbjct: 400 KEHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSN--EKNAKVKELN 457
Query: 366 EKHRGMLEKSN--QNLQLEAENLVQRI--------ASKDHELLEKHTEIERLQTLMHGEH 415
K++ ++E N Q L + +L ++I S D + + EI+ +Q +M +
Sbjct: 458 AKNQKLVECENDLQTLTKQRLDLCRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDD 517
Query: 416 SNFIQIESALQALQKLYSQS---QKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVE 472
S + +S ++L Q +++N L LK L LE ++ K+ +Q I
Sbjct: 518 STITESDSQKVVTERLVEFKNIIQLQEKNAEL-LKVVRNLADKLESKEKKSKQSLQKI-- 574
Query: 473 ENKTLHELNFSSTRSLKKQQMEI-SKLKEIKEKLEREFHTSTEE-----SNVLQRETHQI 526
E++T++E + +LK ++M++ S+++E++++LE E TS SNV ++ +
Sbjct: 575 ESETVNEAK-EAIITLKSEKMDLESRIEELQKELE-ELKTSVPNEDASYSNVTIKQLTET 632
Query: 527 KDDIQHLNERYQAMLEQLQSLGL-NPNSFAASVRDLQNENFMLKETCKKEHSEKEALREK 585
K D++ + Q + Q+ N + ++DL + + KE S + E+
Sbjct: 633 KRDLESQVQDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEER 692
Query: 586 SKDMNEVLMENACMEFSLLGLNDELDGLRGTV-KEIQQFCQVLQEE---KSILADEKSTL 641
K ++ L L D L+ T+ K+ + + L E KS L+ ++ L
Sbjct: 693 FKLLSNTLDLTKAENDQL---RKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETEL 749
Query: 642 LSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNER 701
L+ + + ++ LE N L++ L+ E + LRI L+ L + ++ L+ R
Sbjct: 750 LNLKE--EQKLRVHLEKN--LKQELNKLSPEKDSLRIMVTQLQT---LQKEREDLLEETR 802
Query: 702 SMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHK 761
+++ +E+ LS L+K+ + + +E+D S + + ++ E+
Sbjct: 803 KSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSV 862
Query: 762 HSSEARLANLENIVRVLQEEQRLGKVEFE--QELDRVVN----------AQIEMFILQNC 809
S + + L+ V+ L++E K+ +D +N ++I + +
Sbjct: 863 DSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQ 922
Query: 810 IEEL----ELKNFVLLTECEKLVEASKFSDKVISELESEN------LMQLIEEEFLLHR- 858
I+E E + L KL E+ K I L E + L E+ F L+
Sbjct: 923 IKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTDEKTSLEDKISLLKEQMFNLNNE 982
Query: 859 -------IRKFKMDIHKVCGVLQIDSDGGGDNEIKKE-EIPISRI---LDKIESLESSLV 907
+ K K D K +LQ ++ +K E E +S+I LD+ ++
Sbjct: 983 LDLQKKGMEKEKADFKKRISILQ--NNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQ 1040
Query: 908 KSQEENQQLLVENSVLLGSLQQ--HQSEGE-------------KLKLEKKTVEQEFENMR 952
+ E+ Q + S + L++ H +G+ LK +K+ + E++
Sbjct: 1041 NNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLL 1100
Query: 953 EQNVILQKDKVELLEENRQL---RIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQ- 1008
EQ + L ++E L +L +I++ +KE + + L +I LR+ +
Sbjct: 1101 EQ-LDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDT 1159
Query: 1009 -----EENGKMLDEKNSLCRNVSDLKDAK-----SSAEDENS---VMFHDVLA--LSNLN 1053
E + KML +K SL +L+DA+ S E EN + HD + L+ LN
Sbjct: 1160 KVTVAERDAKMLRQKISLMD--VELQDARTKLDNSRVEKENHSSIIQQHDDIMEKLNQLN 1217
Query: 1054 LVYEIFFT------ENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNE 1107
L+ E T N +K+ L L L + E L+ + + KE E E
Sbjct: 1218 LLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKE 1277
Query: 1108 SIERMDK---ELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSEN 1164
+ R K ++LE ++L +++ E IE LK E E N +RQ E E
Sbjct: 1278 EVHRWKKRSQDILEKHEQLSSSDYEKLE--SEIENLKEELE-------NKERQGAEAEEK 1328
Query: 1165 CMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAF 1224
+++ + E +T + +L +V R + L L +EA A
Sbjct: 1329 FNRLRRQAQ---ERLKTSKLSQDSLTEQVNSLRDAKNVLENSL-----------SEANAR 1374
Query: 1225 YHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
+LQ + + ++L + K+ +D A + E + ES I GL E+
Sbjct: 1375 IEELQNAKVAQGN-----NQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEE- 1428
Query: 1285 SAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVL 1344
+++LKE+ I ++ Q D+ + + + +S E++I
Sbjct: 1429 ------ITTLKEEIEKQRQIQ----QQLQATSANEQNDL---SNIVESMKKSFEEDKIKF 1475
Query: 1345 IPDGVSD----LLTLQTRIRAVEKIMMEELKRR--------VKQKSLTTESTPYSSLEIA 1392
I + + +L Q R+ I MEE+K++ V QK E + +
Sbjct: 1476 IKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLP 1535
Query: 1393 TYPKV----ENRKKEIEL-VEENVFDR-NSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKR 1446
T K+ E +K+E+E EE V +R S + +I D+ L + ++ +K ++
Sbjct: 1536 TEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEI-----DVVLRKQLE---AKVQEK 1587
Query: 1447 EHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLE 1506
+ N++ +L E + P S+ H SDD L E + +E E
Sbjct: 1588 QKELENEYNKKLQEELKDVPHSS---------HISDDERDKLRAEIESRLREEFNN---E 1635
Query: 1507 LSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKR 1566
L K+ ++ K++ + + + +KLA ++ L + K+ E+ KS + R
Sbjct: 1636 LQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPPKSVNNVQNPLLGLPR 1695
Query: 1567 HIEEVEEAVMQQVSINDQMAK 1587
IEE + + +++ K
Sbjct: 1696 KIEENSNSPFNPLLSGEKLLK 1716
Score = 133 bits (335), Expect = 4e-30
Identities = 288/1499 (19%), Positives = 610/1499 (40%), Gaps = 182/1499 (12%)
Query: 175 SLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLET 234
SL+ + ++T++ + ++ ++ E ++ M+L ++ + + + E
Sbjct: 74 SLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEE 133
Query: 235 IARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRM 294
+S + I + LK E+ V V+ + + K+ I LE K + +
Sbjct: 134 KKETQSNQQRTLKILDERLK-EIELVRVENNRSNSECKKLRSTIMDLETK-----QQGYI 187
Query: 295 LNDQIERTELEVETLRKNLAEMNEE--RDSLSVLYHHCLEKISKMENEILHVQENAEQLK 352
ND RTELE +T L + N + L L K + IL ++ +L+
Sbjct: 188 TNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLR 247
Query: 353 NKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMH 412
N + E ++ ++ L KS Q LE + L + S+ E + + +RL L+
Sbjct: 248 NDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLE 307
Query: 413 GEHSNFIQIESALQALQ--KLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGI 470
+ + + ++++ L K+ + K+Q +L LK+L+L+K+ + +
Sbjct: 308 SQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDL------LKELQLTKEKLAQCEKEC 361
Query: 471 VEENKTLHELNFSSTRSLKKQQMEISKLKE--IKEKLEREFHTSTEESNVLQRETHQIKD 528
+ + E + + K + LK+ IKE+ +E + E+ +++ E H++
Sbjct: 362 LRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELE-HKVPI 420
Query: 529 DIQHLNERYQAMLEQLQSLGL----NPNSFAASVRDLQNENFMLKETCKKEHSEKEALRE 584
I ER + +L + L N A V++L +N L E + + +
Sbjct: 421 -INSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLD 479
Query: 585 KSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKST-LLS 643
+ + +L+ N+ ND LR +EIQ ++QE+ S + + S +++
Sbjct: 480 LCRQIQYLLITNSVS-------NDSKGPLRK--EEIQFIQNIMQEDDSTITESDSQKVVT 530
Query: 644 QLQIITESMQKILENNTVLEK---SLSDAKIEFEGLRIKSGDLEDCCKLLNDEKN---NL 697
+ + +++ ++ E N L K +L+D K+E + + K + + +N+ K L
Sbjct: 531 ERLVEFKNIIQLQEKNAELLKVVRNLAD-KLESKEKKSKQSLQKIESETVNEAKEAIITL 589
Query: 698 QNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVE-----KDKESAVNQVEELFASILV 752
++E+ L S++E ++++L L+ V N + Y++V + K +QV++L I
Sbjct: 590 KSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRI-- 647
Query: 753 QKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEE 812
S S ++ L ++ L + + ++ +E + A+ +L N ++
Sbjct: 648 -----SQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDL 702
Query: 813 LELKNFVLLTECEKLVEA-----SKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIH 867
+ +N L + L SK + + + ++ + ++E E LL+ + K+ +H
Sbjct: 703 TKAENDQLRKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETE-LLNLKEEQKLRVH 761
Query: 868 KVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVEN----SVL 923
+ +K+E +S D + + + L Q+E + LL E
Sbjct: 762 L-------------EKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEETRKSCQKK 808
Query: 924 LGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNG---- 979
+ L+ SE +K +K ++ E N+ ++K+E L+++ + I V+
Sbjct: 809 IDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTD 868
Query: 980 VEK-ENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDE 1038
+EK + + KS ++ + I L N + + N L + L ++ +L DA S ++
Sbjct: 869 IEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSL--RKELEKSKINLTDAYSQIKEY 926
Query: 1039 NSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVK 1098
+ +L N + F + + NL+ L + +L++
Sbjct: 927 KDLYETTSQSLQQTNSKLDESFKD-------FTNQIKNLTDEKTSLEDKISLLKEQMFNL 979
Query: 1099 EAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEES-TKIKENLDRQ 1157
E L+ + M+KE + KR+ + +N E +E +K E E +KI+ +LD+Q
Sbjct: 980 NNE---LDLQKKGMEKEKADFKKRISILQNNNKE----VEAVKSEYESKLSKIQNDLDQQ 1032
Query: 1158 ILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNL-----ELLNKEN 1212
+ + N+++E++ + ++T+ E++ LH ++ + + LNL E KEN
Sbjct: 1033 TIYANTAQNNYEQELQKHADVSKTIS-ELREQLHT---YKGQVKTLNLSRDQLENALKEN 1088
Query: 1213 EFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISL 1272
E K W ++ + L +S+ S++ +L+ K+L D+ + ++ + +
Sbjct: 1089 E-KSWSSQKESLLEQLDLSN-------SRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNG 1140
Query: 1273 --LESEIGGLKEQLSAYVPLVSSLKEDFNSL-EHISLLWTKRNSVVGNGAQKDVVIETCL 1329
L + + L+ + V+ + D L + ISL+ + + + + +
Sbjct: 1141 PGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDA------RTKLDNSRV 1194
Query: 1330 RKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSL 1389
K +H S I+ D + + L +R + EL+ +K
Sbjct: 1195 EKENHSS-----IIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKK------------ 1237
Query: 1390 EIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHR 1449
+ + E++ +++NV S K + K+ Q K K E
Sbjct: 1238 --------KELQSELDKLKQNVAPIESELTALKYSMQEKE---------QELKLAKEEVH 1280
Query: 1450 RTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSK 1509
R ++ E +HE LS S Y SE++ KE +K
Sbjct: 1281 RWKKRSQDILE--KHEQLS---------------SSDYEKLESEIENLKEELENKERQGA 1323
Query: 1510 SVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIE 1569
+EK +R+ ERL + K++ L ++ + + +K + IE
Sbjct: 1324 EAEEKFNRLRRQAQERLKTS-------KLSQDSLTEQVNSLRDAKNVLENSLSEANARIE 1376
Query: 1570 EVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEE 1628
E++ A + Q + + + ++E A RE+ + E + + + + L EE
Sbjct: 1377 ELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEE 1435
Score = 57.8 bits (138), Expect = 2e-07
Identities = 140/687 (20%), Positives = 288/687 (41%), Gaps = 103/687 (14%)
Query: 1010 ENGKMLDEKNSLCRNV--SDLKDAKSSAEDENSVMFHDVLALSNL---NLVYEIFFTE-- 1062
+NG+ DE+ + + L+ KS D + +L + L NL + F E
Sbjct: 12 QNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELK 71
Query: 1063 --NMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMD 1120
++ + L + N+ N+ + +E FE E E + L+ +E + ++L ++
Sbjct: 72 ASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLT 131
Query: 1121 KRLKAAETSNAEFSRHIEELKMEQEESTKIKEN-------------LDRQILEQS--ENC 1165
+ K + SN + + I + ++++ E +++ N +D + +Q N
Sbjct: 132 EEKKETQ-SNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLETKQQGYITND 190
Query: 1166 MNHKKEIEH-------LNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWE 1218
+N + E+E L N+ L+ E+++ + +R + + + L++ N+ N + +
Sbjct: 191 LNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLRN-D 249
Query: 1219 NEAAAFYHDL--QMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESE 1276
+ +D+ Q ++ L+ K+ E+ G+ L+ E S E + ++ LLES+
Sbjct: 250 FQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQ 309
Query: 1277 IGGLKEQLSAYVPLVSS----------LKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIE 1326
+ +KE+L++ L ++ E+ + L+ + L K AQ + +
Sbjct: 310 LNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKL-------AQCE---K 359
Query: 1327 TCLRKHS-HQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTP 1385
CLR S A E+ L SD + L +K +++E RR K+ T
Sbjct: 360 ECLRLSSITDEADEDNENLSAKSSSDFIFL-------KKQLIKE--RRTKEHLQNQIETF 410
Query: 1386 YSSLEIATYPKVENRKKEIELVEEN------VFDRNSWRKKPKIRLLMKDIPLDRNVDDQ 1439
LE P + + K+ +++E + + S K K++ L N +Q
Sbjct: 411 IVELE-HKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKEL--------NAKNQ 461
Query: 1440 NSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHR-SDDSGRYLNYSSELDIEK 1498
+ + + L+LC + + +I + S+DS L I+
Sbjct: 462 KLVECENDLQTLTKQRLDLCRQ----------IQYLLITNSVSNDSKGPLRKEEIQFIQN 511
Query: 1499 ELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETK-KKSKQG- 1556
+ D +++S +K ++ + + +K A L +++L K E+K KKSKQ
Sbjct: 512 IMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKLESKEKKSKQSL 571
Query: 1557 NDIEYETV---KRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDRE-------IPRRGSE 1606
IE ETV K I ++ M S +++ K +EE +S+ E ++ +E
Sbjct: 572 QKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTE 631
Query: 1607 QIGKLQFEVQNIQYILLKLAEENNNKV 1633
L+ +VQ++Q + ++ E+ +
Sbjct: 632 TKRDLESQVQDLQTRISQITRESTENM 658
>MYHB_RABIT (P35748) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 156 bits (394), Expect = 5e-37
Identities = 231/1150 (20%), Positives = 473/1150 (41%), Gaps = 129/1150 (11%)
Query: 129 TSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNK 188
T +P + + E + E+Q ++E K +S+ L ++ + E + ++ L
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKIKERQQKAESELQELQQKHTQLSEEKNLLQEQLQA 898
Query: 189 -----AQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLS 243
A+ + A + E++ EIL E +L+ ++D G+ L + + ++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 244 QKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTE 303
Q + EA K +L +V + KI LE+ I + ++ + L+ + + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAE------------AKIKKLEDDILVMDDQNNKLSKERKLLE 1005
Query: 304 LEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQ---ENAEQLKNKIEKEAE 360
+ L NLAE E+ +L+ L + IS++E + + + E+LK K++ EA
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKMDGEAS 1065
Query: 361 KL--EISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNF 418
L +I++ + E Q L + E L +A + E +K+ +++++ L +
Sbjct: 1066 DLHEQIADLQAQIAELKMQ-LAKKEEELQAALARLEDETSQKNNALKKIREL----EGHI 1120
Query: 419 IQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD----------LELSKQDFKEEMQ 468
++ L + + ++++K++R+L EL+ L+D L ++ ++
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDTTATQQELRAKREQEVTVLK 1180
Query: 469 GIVEENKTLHELNFSSTRSLKKQQME-----ISKLKEIKEKLEREFHTSTEESNVLQRET 523
++E HE R Q +E + + K K L++ T +E+ L E
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHTQVVEELTEQLEQFKRAKANLDKTKQTLEKENADLAGEL 1240
Query: 524 H---QIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRD----LQNE----NFMLKET- 571
Q K +++H ++ + L++LQS + A + D LQNE ML E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEVQLQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLSEAE 1300
Query: 572 --CKKEHSEKEALREKSKDMNEVLMENACMEFS----LLGLNDELDGLRGTVKEIQQFCQ 625
K E +L + +D E+L E + + L L DE + L+ + E + Q
Sbjct: 1301 GKAIKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQEQLDEEMEAKQ 1360
Query: 626 VLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLED 685
L+ S L + S +LQ +++ + E +K + ++E LE
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVESLEEGKKRFQKEIESLTQQYEEKAAAYDKLE- 1419
Query: 686 CCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEE 745
KN LQ E L+ L+ + +SNLEKK ++ A+ EK+ +
Sbjct: 1420 ------KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAE-EKN-------ISS 1465
Query: 746 LFASILVQKENHSNHKHSSEARLAN-LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMF 804
+A + E + K + LA LE + +E +R K+ + E++ +V+++ +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDLVSSKDD-- 1522
Query: 805 ILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKM 864
+ + ELE L T+ E E + ++ +E+E K ++
Sbjct: 1523 -VGKNVHELEKSKRALETQME----------------EMKTQLEELEDELQATEDAKLRL 1565
Query: 865 DIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLL 924
+++ +Q + D +E +E K L+ L + + E + + ++
Sbjct: 1566 EVNMQALKVQFERDLQARDEQNEE---------KRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 925 GSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQ---KDKVELLEENRQLRIEVVNGVE 981
+ ++ + + + L+L+ + + E +Q + LQ KD LE+ R R E+
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLLKLQAQMKDFQRELEDARASRDEIF-ATA 1675
Query: 982 KENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSV 1041
KEN K+ +L+A++++L++ + + EK L ++ +++ +DE
Sbjct: 1676 KENEKKA--KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 1042 MFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAE 1101
+ + L E E A+ + + + L+ E R + E+
Sbjct: 1734 LEARIAQL-------EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 1102 NVYLNESIERMDKELLEMDKRLK--------AAETSNAEFSRHIEELKMEQEESTKIKEN 1153
L + + +L EM+ +K A E A+ +E+ E++ + K +
Sbjct: 1787 RQQLERQNKELKSKLQEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAKALKQ 1846
Query: 1154 LDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNL--ELLNKE 1211
D+++ E + +K E E E ++K L ++E+ + +N L +E
Sbjct: 1847 RDKKLKEMLLQVEDERKMAEQYKEQAEKGNAKVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 1212 NEFKLWENEA 1221
+ NEA
Sbjct: 1907 LDEATESNEA 1916
Score = 129 bits (324), Expect = 7e-29
Identities = 233/1238 (18%), Positives = 491/1238 (38%), Gaps = 215/1238 (17%)
Query: 275 LEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKI 334
L ++ E ++ E+ + + ++ ++ E E++ L++ +++EE++ L E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKIKERQQKAESELQELQQKHTQLSEEKNLLQEQLQAETELY 903
Query: 335 SKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKD 394
++ E + + ++L+ + + +LE E+ RG Q LQ E + + Q++ +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRG------QQLQAERKKMAQQMLDLE 956
Query: 395 HELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLK 454
+L E+ ++LQ + ++E + + ++ KE++ L +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERIS------- 1009
Query: 455 DLELSKQDFKEEMQGIVEENKTLHELNFSSTR-SLKKQQMEISKLKEIKEKLEREFHTST 513
DL + + +E+ + + + K HE S LKK++ +L+++K K++ E
Sbjct: 1010 DLTTNLAEEEEKAKNLTKL-KNKHESMISELEVRLKKEEKSRQELEKLKRKMDGEASDLH 1068
Query: 514 EESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCK 573
E+ LQ + ++K + E QA L +L+ N+ +R+L+ L+E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLEDETSQKNNALKKIRELEGHISDLQEDLD 1128
Query: 574 KEHSEKEALREKSKDMNEVL------MENAC--------------MEFSLL--GLNDELD 611
E + + ++ +D+ E L +E+ E ++L L++E
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDTTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 612 GLRGTVKEIQQ-FCQVLQE-----------------EKSILADEKSTLLSQLQIITESMQ 653
V+E++Q QV++E K L E + L +L+++ ++ Q
Sbjct: 1189 SHEAQVQEMRQKHTQVVEELTEQLEQFKRAKANLDKTKQTLEKENADLAGELRVLGQAKQ 1248
Query: 654 KILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEE 713
++ LE ++ + L+ K D E LND+ + LQNE + L E
Sbjct: 1249 EVEHKKKKLE-------VQLQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLSEAEG 1301
Query: 714 KLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLEN 773
K L K+V +L + D ++ L+Q+E + K + +L LE+
Sbjct: 1302 KAIKLAKEVASLGSQLQDTQE----------------LLQEE--TRQKLNVSTKLRQLED 1343
Query: 774 IVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKF 833
LQE+ ++ E E + + I +Q + +L++F + E L E K
Sbjct: 1344 ERNSLQEQ-----LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA--STVESLEEGKKR 1396
Query: 834 SDKVISELESENLMQLIEEEFLLH-RIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPI 892
K E E+L Q EE+ + ++ K K + + L +D D
Sbjct: 1397 FQK-----EIESLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-------------- 1437
Query: 893 SRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMR 952
NQ+ LV N L++ Q + ++L E+K + ++ +
Sbjct: 1438 --------------------NQRQLVSN------LEKKQKKFDQLLAEEKNISSKYAD-- 1469
Query: 953 EQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEM---IELRQTNQVFQE 1009
++D+ E EKE ++ S AL+ + EL +TN++ +
Sbjct: 1470 ------ERDRAE------------AEAREKETKALSLARALEEALEAKEELERTNKMLKA 1511
Query: 1010 ENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRA 1069
E ++ K+ + +NV +L+ +K + E + M + L + E+ TE+ +
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED-----ELQATEDAKLRLE 1566
Query: 1070 LCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETS 1129
+ N+ L ++ L+ E E + L + + EL + K+ A +
Sbjct: 1567 V-----NMQALKVQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 1130 NAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTL 1189
+ +++L+++ + + K +E +Q+L+ LQ +MK
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLLK---------------------LQAQMKDF 1657
Query: 1190 LHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVC 1249
E+E R + + E + K E + DL + + + EL
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-- 1715
Query: 1250 KILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWT 1309
++ S +L++E R LE+ I L+E+L + ++ + + +
Sbjct: 1716 ELASSLSGRNALQDEKRR-----LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 1310 KRNSVVGNGAQKDVVIETCLRKHSHQ---SARENEIVLIPDGVSDLLTLQTRIRAV-EKI 1365
+ + AQK+ L + + + +E E + S + L+ +I + E++
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELKSKLQEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 1366 MMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRL 1425
E +++ K+L + + +VE+ +K E +E N+ K+ K +L
Sbjct: 1831 EQEAREKQAAAKALKQRDKKLKEMLL----QVEDERKMAEQYKEQAEKGNAKVKQLKRQL 1886
Query: 1426 LMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNE 1463
++ S+ + R+ + E E+NE
Sbjct: 1887 ---------EEAEEESQRINANRRKLQRELDEATESNE 1915
Score = 116 bits (290), Expect = 6e-25
Identities = 228/1123 (20%), Positives = 436/1123 (38%), Gaps = 155/1123 (13%)
Query: 535 ERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
E QA ++LQ + + +++LQ ++ L E EK L+E+ + E+
Sbjct: 852 EEMQAKEDELQKIKERQQKAESELQELQQKHTQLSE-------EKNLLQEQLQAETELYA 904
Query: 595 ENACMEFSLLGLNDELDGL----RGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
E M L EL+ + ++E + Q LQ E+ +A + L QL+
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEI 710
+ QK+ LEK ++AKI+ LED +++D+ N L ER +L
Sbjct: 965 ARQKLQ-----LEKVTAEAKIK---------KLEDDILVMDDQNNKLSKERKLL------ 1004
Query: 711 VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN 770
EE++S+L + EEK ++ K K + + EL + ++KE S +
Sbjct: 1005 -EERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL--EVRLKKEEKSRQE--------- 1052
Query: 771 LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEA 830
LE + R + E EQ D + AQI +Q +E EL+ L E
Sbjct: 1053 LEKLKRKMDGE---ASDLHEQIAD--LQAQIAELKMQLAKKEEELQ--AALARLEDETSQ 1105
Query: 831 SKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEI 890
+ K I ELE + ++E+ R + K + K D G + E K E+
Sbjct: 1106 KNNALKKIRELEGH--ISDLQEDLDSERAARNKAEKQK--------RDLGEELEALKTEL 1155
Query: 891 PISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFEN 950
D +++ + + Q++ V L + H+++ ++++ + V +E
Sbjct: 1156 E-----DTLDTTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQVVEELTE 1210
Query: 951 MREQ----NVILQKDKVELLEENRQL--RIEVVNGVEKENRSKSTLAALQAEMIELRQTN 1004
EQ L K K L +EN L + V+ ++E K L+ ++ EL+
Sbjct: 1211 QLEQFKRAKANLDKTKQTLEKENADLAGELRVLGQAKQEVEHKKK--KLEVQLQELQSKC 1268
Query: 1005 QVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENM 1064
+ ++ D+ + L V + S AE + + +V +L + + E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLSEAEGKAIKLAKEVASLGSQLQDTQELLQEET 1328
Query: 1065 VEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLK 1124
+K + L L N L ++ + + E LN + K+L + ++
Sbjct: 1329 RQKLNVSTKLRQLEDERNSLQEQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 1125 AAETSNAEFSRHIEELKMEQEEST-------KIKENLDRQILEQSENCMNHKKEIEHLNE 1177
+ E F + IE L + EE K K L +++ + + N ++ + +L +
Sbjct: 1389 SLEEGKKRFQKEIESLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 1178 AN---ETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSIC 1234
+ L E K + + R R EA E K EA +L+ ++
Sbjct: 1449 KQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 1235 L-ALLESKVSELTGVCKILDD-ESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVS 1292
L A +E VS V K + + E S ++LE + M E+ + LE L+++L A
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-MEEMKTQLEE----LEDELQATEDAKL 1563
Query: 1293 SLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDL 1352
L+ + +L+ V E L+ Q+ +
Sbjct: 1564 RLEVNMQALK--------------------VQFERDLQARDEQNEEKRR----------- 1592
Query: 1353 LTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVF 1412
LQ ++ E + +E K+R +L A K+E K++EL ++
Sbjct: 1593 -QLQRQLHEYETELEDERKQR--------------ALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 1413 DRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTV 1472
K ++L + R ++D R + D + + NE + S
Sbjct: 1638 KGREEAIKQLLKLQAQMKDFQRELEDA---------RASRDEIFATAKENEKKAKSL--- 1685
Query: 1473 DHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQK 1532
A + +D + D+EKE ++L S S + +D+KRR+ R++ ++
Sbjct: 1686 -EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 1533 LAILKMALQDLKKKTETKKKSKQGNDIEYE-TVKRHIEEVEEAVMQQVSINDQMAKNVEE 1591
L + ++ + + +K ++Q + E +R + E+ QQ+ ++ K ++
Sbjct: 1745 LEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQL---ERQNKELKS 1799
Query: 1592 GASSLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVK 1634
++ + + I L+ ++ ++ + + A E K
Sbjct: 1800 KLQEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAK 1842
Score = 113 bits (283), Expect = 4e-24
Identities = 194/1042 (18%), Positives = 405/1042 (38%), Gaps = 138/1042 (13%)
Query: 18 DSHNSPKNSKWLLE--------NLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELM 69
D +N + LLE NL + + K K++ KL + + +S E+ KK +
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL-KNKHESMISELEVRLKKEEKSR 1050
Query: 70 KLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHT 129
+ +E+ R + D +L + + + + E T
Sbjct: 1051 QELEKLKR-------KMDGEASDLHEQIADLQAQIAELKMQLAKKEEELQAALARLEDET 1103
Query: 130 SARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKA 189
S + K E G + L+E L ++ ++ Q ++ E L ++T+L
Sbjct: 1104 SQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 190 QNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIE 249
+ + ++ E +V +LK++L + +A +
Sbjct: 1159 LDTTATQQELRAKREQEVTVLKKALDEETRSHEA-------------------------Q 1193
Query: 250 AKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETL 309
+ ++Q+ T+VV + L Q+K+ K + + K L +EN+ + E+ L
Sbjct: 1194 VQEMRQKHTQVVEELTEQLEQFKRA--KANLDKTKQTLEKENADLAG--------ELRVL 1243
Query: 310 RKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHR 369
+ E+ ++ L V K S E + + +L+N++E L +E
Sbjct: 1244 GQAKQEVEHKKKKLEVQLQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLSEAEGKA 1303
Query: 370 GMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQ 429
L K +L + ++ + + + + L T++ Q+E +LQ
Sbjct: 1304 IKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLR--------------QLEDERNSLQ 1349
Query: 430 KLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLK 489
+ + + ++NL + + L D + QDF ++ + E K + S T+ +
Sbjct: 1350 EQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVESLEEGKKRFQKEIESLTQQYE 1409
Query: 490 KQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGL 549
++ KL++ K +L++E ++ V Q+ ++ E+ Q +QL +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQEL----DDLVVDLDNQRQLVSNL----EKKQKKFDQLLAEEK 1461
Query: 550 NPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDE 609
N +S A RD KET K S AL E + E+ N ++ + L
Sbjct: 1462 NISSKYADERDRAEAEAREKET--KALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 610 LDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDA 669
D + V E L++ K L + + +QL+ + + +Q + LE ++
Sbjct: 1520 KDDVGKNVHE-------LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 670 KIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKY 729
K++FE DL+ + +++ LQ + ++LE ++ + LE
Sbjct: 1573 KVQFE------RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 730 ADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEF 789
D+E +SA+ EE +L + + + E A+ + I +E ++ K
Sbjct: 1627 KDLELQADSAIKGREEAIKQLLKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK-SL 1685
Query: 790 EQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQL 849
E +L + Q ++ + ++ +L E + ++++ S L N +Q
Sbjct: 1686 EADL---MQLQEDLAAAERARKQADL-------------EKEELAEELASSLSGRNALQ- 1728
Query: 850 IEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKS 909
E+ L RI + + ++ + G ++ SD ++K ++ +++ + S+ K+
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQAEQLSNELATERSTAQKN 1783
Query: 910 QEENQQLLVENSVLLGSLQQHQS-------------EGEKLKLEKKTVEQEFENMREQNV 956
+ QQL +N L LQ+ + E + +LE++ ++ E
Sbjct: 1784 ESARQQLERQNKELKSKLQEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAKA 1843
Query: 957 ILQKDK--VELL---EENRQLRIEVVNGVEKEN----RSKSTLAALQAEMIELRQTNQVF 1007
+ Q+DK E+L E+ R++ + EK N + K L + E + +
Sbjct: 1844 LKQRDKKLKEMLLQVEDERKMAEQYKEQAEKGNAKVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 1008 QEENGKMLDEKNSLCRNVSDLK 1029
Q E + + ++ R V+ LK
Sbjct: 1904 QRELDEATESNEAMGREVNALK 1925
Score = 112 bits (279), Expect = 1e-23
Identities = 204/1088 (18%), Positives = 421/1088 (37%), Gaps = 156/1088 (14%)
Query: 30 LENLTDIDTKVKSMIKLIEE----EADSFARRAEMYYKKRPELMKLVEEFYRAYRALAER 85
L+ L T++ L++E E + +A EM + + +L E + L E
Sbjct: 875 LQELQQKHTQLSEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 86 YDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSE 145
D +L+ K M + + + +++ L E T+ + + + +
Sbjct: 935 EDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKL--QLEKVTAEAKIKKLEDDILVMD 991
Query: 146 ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKM-----------ETDLNKAQNNA- 193
+ N ++ R+ L + SD + +E +NL+K+ E L K + +
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 194 ------RGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDN 247
R +D AS+ Q+ L+ + +LK E + +ARLE SQK+N
Sbjct: 1052 ELEKLKRKMDGEASDLHEQIADLQAQIAELKMQLAKKE---EELQAALARLEDETSQKNN 1108
Query: 248 IEAK---------NLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQ 298
K +L+++L ++ Q + E++ L+ ++ + + +
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDTTATQQEL 1168
Query: 299 IERTELEVETLRKNLAEMNEERDS----LSVLYHHCLEKISKMENEILHVQENAEQLKNK 354
+ E EV L+K L E ++ + + +E++++ + + N ++ K
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQVVEELTEQLEQFKRAKANLDKTKQT 1228
Query: 355 IEKE----AEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTL 410
+EKE A +L + + + +E + L+++ + L + + + E + ++ +LQ
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 411 MHGEHSNFIQIE--------------SALQALQKLYSQSQKEQRNLALELKYGLLLLKDL 456
+ + E S LQ Q+L + +++ N++ +L+ L+D
Sbjct: 1289 VESVTGMLSEAEGKAIKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLRQ----LEDE 1344
Query: 457 ELSKQD-FKEEMQGIVEENKTLHELNFSSTRSLKKQQ---MEISKLKEIKEKLEREFHTS 512
S Q+ EEM+ + + LN + S KK Q + L+E K++ ++E +
Sbjct: 1345 RNSLQEQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVESLEEGKKRFQKEIESL 1404
Query: 513 TEE--------------SNVLQRETHQIKDDIQHLN------ERYQAMLEQLQSLGLNPN 552
T++ N LQ+E + D+ + E+ Q +QL + N +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNIS 1464
Query: 553 SFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDG 612
S A RD KET K S AL E + E+ N ++ + L D
Sbjct: 1465 SKYADERDRAEAEAREKET--KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 613 LRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIE 672
+ V E L++ K L + + +QL+ + + +Q + LE ++ K++
Sbjct: 1523 VGKNVHE-------LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKVQ 1575
Query: 673 FEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADV 732
FE DL+ + +++ LQ + ++LE ++ + LE D+
Sbjct: 1576 FER------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 733 EKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGK------ 786
E +SA+ EE +L + + + E A+ + I +E ++ K
Sbjct: 1630 ELQADSAIKGREEAIKQLLKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 787 VEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENL 846
++ +++L A+ + + + EEL + L+ L + + + I++LE E
Sbjct: 1690 MQLQEDLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 847 MQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPI-------------- 892
+ E + R+RK ++ L + NE ++++
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELKSKLQEMEG 1806
Query: 893 ---SRILDKIESLESSLVKSQEENQQLLVENSVLLGSL---------------------Q 928
S+ I +LE+ + + +E+ +Q E +L +
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAKALKQRDKKLKEMLLQVEDERKMAE 1866
Query: 929 QHQSEGEK-------LKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVE 981
Q++ + EK LK + + E+E + + LQ++ E E N + EV
Sbjct: 1867 QYKEQAEKGNAKVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 982 KENRSKST 989
K R T
Sbjct: 1927 KLRRGNET 1934
Score = 90.1 bits (222), Expect = 5e-17
Identities = 111/519 (21%), Positives = 225/519 (42%), Gaps = 31/519 (5%)
Query: 25 NSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAE 84
N + L+ NL + K K +L+ EE + ++ A+ + E + + RAL E
Sbjct: 1438 NQRQLVSNL---EKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
+ A EL +K + + +++ G + E A T + ++ +
Sbjct: 1495 ALE-AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALET-QMEEMKTQL 1548
Query: 145 EESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAE 204
EE E+Q +A +++ + AL +Q++ L+ ++ E + K + R L + E E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKVQFERDLQ--ARDEQNEEKRRQLQRQLHEY--ETE 1604
Query: 205 IQVEILKESLMQLKADKDAGEV--LYNQCLETIARLESMLSQKDNIEA--KNLKQELTRV 260
++ E + +L K G++ L Q I E + Q ++A K+ ++EL
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLLKLQAQMKDFQRELEDA 1664
Query: 261 VVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEER 320
+D + K+ +K LE + +E+ ++ +LE E L + LA R
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 321 DSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQ 380
++L +I+++E E+ Q N E + +++ K ++ E + Q
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ--- 1781
Query: 381 LEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQR 440
+ E+ Q++ ++ EL K E+E + S +E+ + L++ Q +E++
Sbjct: 1782 -KNESARQQLERQNKELKSKLQEMEG--AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 441 NLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQ----QMEIS 496
A LK LK++ L +D ++ + E+ K E + + LK+Q + E
Sbjct: 1839 AAAKALKQRDKKLKEMLLQVEDERK----MAEQYKEQAEKGNAKVKQLKRQLEEAEEESQ 1894
Query: 497 KLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNE 535
++ + KL+RE +TE + + RE + +K ++ NE
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 79.7 bits (195), Expect = 6e-14
Identities = 157/826 (19%), Positives = 340/826 (41%), Gaps = 98/826 (11%)
Query: 868 KVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSL 927
KV +LQ+ + E++ +E + +I ++ + ES L + Q+++ QL E ++L L
Sbjct: 840 KVKPLLQVTRQ---EEEMQAKEDELQKIKERQQKAESELQELQQKHTQLSEEKNLLQEQL 896
Query: 928 QQHQ---SEGEKLKLEKKTVEQEFENM---REQNVILQKDKVELLEENR----QLRIEVV 977
Q +E E++++ +QE E + E + ++D+ + L+ R Q +++
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 978 NGVEKENRSKSTL----AALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKS 1033
+E+E ++ L +A++ +L V ++N K+ E+ L +SDL +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERISDL--TTN 1014
Query: 1034 SAEDENSVMFHDVLALSNLNLVYEIFFTENMVEK-RALCEHL-----GNLSHLNN---DL 1084
AE+E L + +++ E+ EK R E L G S L+ DL
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKMDGEASDLHEQIADL 1074
Query: 1085 NQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQ 1144
+ L+ KE E L ++ R++ E + + LK E HI +L+ +
Sbjct: 1075 QAQIAELKMQLAKKEEE---LQAALARLEDETSQKNNALKKIR----ELEGHISDLQEDL 1127
Query: 1145 EESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQ----------------FEMKT 1188
+ + ++Q + E K E+E + T Q + +T
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDTTATQQELRAKREQEVTVLKKALDEET 1187
Query: 1189 LLHEVEQHRVREEALNL--ELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELT 1246
HE + +R++ + EL + +FK A A + + LE + ++L
Sbjct: 1188 RSHEAQVQEMRQKHTQVVEELTEQLEQFK----RAKANLDKTKQT------LEKENADLA 1237
Query: 1247 GVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISL 1306
G ++L E EH ++ LE ++ L+ + S + L + + L++
Sbjct: 1238 GELRVLGQAKQ----EVEHKKK---KLEVQLQELQSKCSDGERARAELNDKVHKLQN--- 1287
Query: 1307 LWTKRNSVVGNGAQKD-VVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVE-- 1363
+ SV G ++ + I+ S S ++ L+ + L + T++R +E
Sbjct: 1288 ---EVESVTGMLSEAEGKAIKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDE 1344
Query: 1364 -KIMMEELKRRVKQKSLTTESTPYSSLEIA-TYPKVENRKKEIELVEENVFDRNSWRKKP 1421
+ E+L ++ K +++++ + K+++ +E +EE R +
Sbjct: 1345 RNSLQEQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVESLEEG-----KKRFQK 1399
Query: 1422 KIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHA----MI 1477
+I L + D+ K R + +D V++L +N+ + +S ++
Sbjct: 1400 EIESLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL--DNQRQLVSNLEKKQKKFDQLL 1457
Query: 1478 CHRSDDSGRYLNYSSELDIE-KELGVDKLELSKSVKEKTE--DDKRRILERLSSDGQKLA 1534
+ S +Y + + E +E L L+++++E E ++ R + L ++ + L
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 1535 ILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGAS 1594
K D+ K +KSK+ + + E +K +EE+E+ + ++ N++
Sbjct: 1518 SSK---DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKV 1574
Query: 1595 SLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISRK 1640
+R++ R + K + + + +L +E + ++K
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Score = 53.5 bits (127), Expect = 5e-06
Identities = 80/384 (20%), Positives = 154/384 (39%), Gaps = 70/384 (18%)
Query: 39 KVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHK 98
K++ +K +E +ADS + E K+ +L +++F R EL A
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLLKLQAQMKDFQR--------------ELEDARA 1666
Query: 99 TMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREAL 158
+ E F + S L E +A ER+ ++++ E + L E L
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAA---------ERARKQADLEKEELAEEL 1717
Query: 159 AKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLK 218
A S ++AL + + ++++E +L + Q N + DR +A Q E L L +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 219 ADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKI 278
+ E Q ++ N E K+ QE+ V K
Sbjct: 1778 STAQKNESARQQL------------ERQNKELKSKLQEMEGAVKSK-------------- 1811
Query: 279 PMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKME 338
++ IA E L +Q+E+ E + K L ++RD +K+ +M
Sbjct: 1812 --FKSTIAALEAKIAQLEEQVEQEAREKQAAAKAL----KQRD----------KKLKEML 1855
Query: 339 NEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRI--ASKDHE 396
++ ++ AEQ K + EK K++ ++ E+ +Q + L + + A++ +E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNAKVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 397 LLEKHTEIERLQT-LMHGEHSNFI 419
+ + E+ L++ L G ++F+
Sbjct: 1916 AMGR--EVNALKSKLRRGNETSFV 1937
>MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 156 bits (394), Expect = 5e-37
Identities = 215/1142 (18%), Positives = 467/1142 (40%), Gaps = 113/1142 (9%)
Query: 129 TSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNK 188
T +P + + E + E+Q +E K +++ L ++ + E + ++ L
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 189 -----AQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLS 243
A+ + A + E++ EIL E +L+ ++D G+ L + + ++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 244 QKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTE 303
Q + EA K +L +V + KI LE++I + ++ + L+ + + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAE------------AKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 304 LEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQ---ENAEQLKNKIEKEAE 360
+ L NLAE E+ +L+ L + IS++E + + + E+LK K+E +A
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 361 KL--EISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNF 418
+I++ + E Q L + E L +A D E+ +K+ +++++ L +
Sbjct: 1066 DFHEQIADLQAQIAELKMQ-LAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHI 1120
Query: 419 IQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLH 478
++ L + + ++++K++R+L EL + K E++ ++ T
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEEL--------------EALKTELEDTLDSTATQQ 1166
Query: 479 ELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQ 538
EL K++ E++ LK+ ++ R +E R+ H ++ L E+ +
Sbjct: 1167 ELR-------AKREQEVTVLKKALDEETRSHEAQVQE----MRQKH--AQAVEELTEQLE 1213
Query: 539 AMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENAC 598
+L N + DL E +L + ++ +K+ L + +++ +
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG-- 1271
Query: 599 MEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILEN 658
E + LND++ L+ V+ + + + LA + ++L SQLQ E +Q+
Sbjct: 1272 -ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 659 NTVLEKSLSDAKIEFEGLRIK-------SGDLEDCCKLLNDEKNNLQNERSMLISQLEIV 711
+ L + E L+ + +LE LN + ++ + + S +E +
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 712 EEKLSNLEKKVTNLEEKYAD-------VEKDKESAVNQVEELFASILVQKENHSN---HK 761
EE +K++ NL ++Y + +EK K ++++L + Q++ SN +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 762 HSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLL 821
+ LA +NI +E+ + E ++ + ++ + EELE N +L
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 822 TECEKLVEASKFSDKVISELES------------ENLMQLIEEEFLLHRIRKFKMDIHKV 869
E E LV + K + ELE + ++ +E+E K +++++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 870 CGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQ 929
Q + D +E +E+ ++ ++ E+ L +++ L G L+
Sbjct: 1571 ALKGQFERDLQARDEQNEEK--RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 930 HQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKST 989
+ + + ++ ++ ++ Q KD LE+ R R E+ KEN K+
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELEDARASRDEIF-ATAKENEKKA- 1682
Query: 990 LAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLAL 1049
+L+A++++L++ + + EK L ++ +++ +DE + + L
Sbjct: 1683 -KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 1050 SNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESI 1109
E E A+ + + + L+ E R + E+ L
Sbjct: 1742 -------EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 1110 ERMDKELLEMDKRLK--------AAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQ 1161
+ + +L EM+ +K A E A+ +E+ E++ +TK + D+++ E
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 1162 SENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNL--ELLNKENEFKLWEN 1219
+ +K E E E +K L ++E+ + +N L +E + N
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 1220 EA 1221
EA
Sbjct: 1915 EA 1916
Score = 134 bits (336), Expect = 3e-30
Identities = 223/1212 (18%), Positives = 480/1212 (39%), Gaps = 163/1212 (13%)
Query: 275 LEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKI 334
L ++ E ++ E+ + ++ ++ E E++ L + +++ EE++ L E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 335 SKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKD 394
++ E + + ++L+ + + +LE E+ RG Q LQ E + + Q++ +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRG------QQLQAERKKMAQQMLDLE 956
Query: 395 HELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLK 454
+L E+ ++LQ + ++E + + ++ KE++ L +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS------- 1009
Query: 455 DLELSKQDFKEEMQGIVEENKTLHELNFSSTR-SLKKQQMEISKLKEIKEKLEREFHTST 513
DL + + +E+ + + + K HE S LKK++ +L+++K KLE +
Sbjct: 1010 DLTTNLAEEEEKAKNLTKL-KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 514 EESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCK 573
E+ LQ + ++K + E QA L +L N+ +R+L+ L+E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 574 KEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSI 633
E + + ++ +D+ E L E L D LD + + Q + K
Sbjct: 1129 SERAARNKAEKQKRDLGEEL------EALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 634 LADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEF----EGLRIKSGDLEDCCKL 689
L +E + +Q+Q + + + +E T + AK + L ++ DL ++
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 690 LNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL--- 746
L K +++++ L +Q++ ++ K S+ E+ L +K ++ + ES + E
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 747 -------FASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNA 799
AS+ Q ++ + N+ +R L+EE+ + + ++E++ N
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 800 QIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLH-R 858
+ + L + + + K + E L E K K E ENL Q EE+ + +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK-----EIENLTQQYEEKAAAYDK 1417
Query: 859 IRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLV 918
+ K K + + L +D D NQ+ LV
Sbjct: 1418 LEKTKNRLQQELDDLVVDLD----------------------------------NQRQLV 1443
Query: 919 ENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVN 978
N L++ Q + ++L E+K + ++ + ++D+ E
Sbjct: 1444 SN------LEKKQRKFDQLLAEEKNISSKYAD--------ERDRAE------------AE 1477
Query: 979 GVEKENRSKSTLAALQAEM---IELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSA 1035
EKE ++ S AL+ + EL +TN++ + E ++ K+ + +NV +L+ +K +
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Query: 1036 EDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNF 1095
E + M + L + E+ TE+ + + N+ L ++ L+
Sbjct: 1538 ETQMEEMKTQLEELED-----ELQATEDAKLRLEV-----NMQALKGQFERD---LQARD 1584
Query: 1096 EVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLD 1155
E E + L + + EL + K+ A + + +++L+++ + + K +E
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1156 RQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFK 1215
+Q+ LQ +MK E+E R + + E + K
Sbjct: 1645 KQL---------------------RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 1216 LWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLES 1275
E + DL + + + EL ++ S +L++E R LE+
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAE--ELASSLSGRNALQDEKRR-----LEA 1736
Query: 1276 EIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQ 1335
I L+E+L + ++ + + + + + AQK+ L + + +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 1336 ---SARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEI- 1391
E E + S + L+ +I +E E++++ ++K T+S ++
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLE----EQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 1392 ATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRT 1451
+VE+ +K E +E N+ K+ K +L ++ S+ + R+
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL---------EEAEEESQRINANRRKL 1903
Query: 1452 NDHVLELCENNE 1463
+ E E+NE
Sbjct: 1904 QRELDEATESNE 1915
Score = 116 bits (290), Expect = 6e-25
Identities = 219/1119 (19%), Positives = 442/1119 (38%), Gaps = 145/1119 (12%)
Query: 535 ERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
E QA ++LQ +++L+ ++ L E EK L+E+ + E+
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-------EKNLLQEQLQAETELYA 904
Query: 595 ENACMEFSLLGLNDELDGL----RGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
E M L EL+ + ++E + Q LQ E+ +A + L QL+
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEI 710
+ QK+ LEK ++AKI+ LED +++D+ N L ER +L
Sbjct: 965 ARQKLQ-----LEKVTAEAKIK---------KLEDEILVMDDQNNKLSKERKLL------ 1004
Query: 711 VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN 770
EE++S+L + EEK ++ K K + + EL + ++KE S +
Sbjct: 1005 -EERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL--EVRLKKEEKSRQE--------- 1052
Query: 771 LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEA 830
LE + R L+ + +F +++ + AQI +Q +E EL+ L + +
Sbjct: 1053 LEKLKRKLEGDAS----DFHEQIADL-QAQIAELKMQLAKKEEELQ--AALARLDDEIAQ 1105
Query: 831 SKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEI 890
+ K I ELE + ++E+ R + K + K D G + E K E+
Sbjct: 1106 KNNALKKIRELEGH--ISDLQEDLDSERAARNKAEKQK--------RDLGEELEALKTEL 1155
Query: 891 PISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFEN 950
D ++S + + Q++ V L + H+++ ++++ + +E
Sbjct: 1156 E-----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 951 MREQ----NVILQKDKVELLEENRQL--RIEVVNGVEKENRSKSTLAALQAEMIELRQTN 1004
EQ L K+K L +EN L + V+ ++E K L+A++ EL+
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK--KLEAQVQELQSKC 1268
Query: 1005 QVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENM 1064
+ ++ D+ + L V + + AE + + DV +LS+ + E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 1065 VEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLK 1124
+K + L L N L + + + E LN + K+L + ++
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 1125 AAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQF 1184
A E F + IE L + EE + L E+++N + + + ++ N+
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKL-----EKTKNRLQQELDDLVVDLDNQ---- 1439
Query: 1185 EMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLA-----LLE 1239
+ L+ +E+ + + + L E N +++ + A A + + ++ LA LE
Sbjct: 1440 --RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 1240 SKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFN 1299
+K EL K+L E + + + + LE L+ Q+ + L+++
Sbjct: 1498 AK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 1300 SLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRI 1359
+ E L + ++D+ R ++ R LQ ++
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQ--------------LQRQL 1598
Query: 1360 RAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFD--RNSW 1417
E + +E K+R +L A K+E K++EL ++ +
Sbjct: 1599 HEYETELEDERKQR--------------ALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1418 RKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMI 1477
++ K++ MKD R ++D R + D + + NE + S A +
Sbjct: 1645 KQLRKLQAQMKDF--QRELEDA---------RASRDEIFATAKENEKKAKSL----EADL 1689
Query: 1478 CHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILK 1537
+D + D+EKE ++L S S + +D+KRR+ R++ ++L +
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 1538 MALQDLKKKTETKKKSKQGNDIEYE-TVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSL 1596
++ + + +K ++Q + E +R + E+ QQ+ ++ K + +
Sbjct: 1750 GNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQL---ERQNKELRSKLHEM 1804
Query: 1597 DREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKN 1635
+ + + I L+ ++ ++ + + A E K+
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Score = 111 bits (278), Expect = 1e-23
Identities = 223/1184 (18%), Positives = 479/1184 (39%), Gaps = 159/1184 (13%)
Query: 490 KQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGL 549
K +++++ +E + E E + E + E +++ L E + EQLQ+
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA--- 898
Query: 550 NPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM-ENACMEFSLLGLND 608
A +++ K+ ++ E EA E+ +D + L E M +L L +
Sbjct: 899 -ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 609 ELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSD 668
+L+ E + Q LQ EK + L ++ ++ + K+ + +LE+ +SD
Sbjct: 958 QLE-------EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 669 AKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEK 728
L + E+ K L L+N+ +IS+LE+ +L EK LE+
Sbjct: 1011 -------LTTNLAEEEEKAKNLT----KLKNKHESMISELEV---RLKKEEKSRQELEKL 1056
Query: 729 YADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKV- 787
+E D Q+ +L A I K + + +A LA L++ + Q+ L K+
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD--EIAQKNNALKKIR 1114
Query: 788 -------EFEQELDRVVNAQIEMFILQNCI-EELELKNFVLLTECEKLVEASKFSDKVIS 839
+ +++LD A+ + + + EELE L TE E ++++ ++ +
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRA 1170
Query: 840 ELESEN--LMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILD 897
+ E E L + ++EE H + +M +K + + +
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMR--------------------QKHAQAVEELTE 1210
Query: 898 KIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVI 957
++E + + + Q L EN+ L G L+ ++++ +KK +E + + ++ +
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 958 LQKDKVELLEENRQLRIEV--VNGVEKENRSKSTLAALQAEMI--ELRQTNQVFQEENGK 1013
++ + EL ++ +L+ EV V G+ E K+ A + +L+ T ++ QEE +
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 1014 MLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEH 1073
L+ L L++ ++S +D+ + ++ A NL + K+ L +
Sbjct: 1331 KLNVSTKL----RQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 1074 LGNLSHLNND---LNQEFGVLRKNFEVKEAENVYLNESIERMDKEL----LEMDKRLKAA 1126
+ L +E L + +E K A L ++ R+ +EL +++D + +
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 1127 ETSNAEFSRHIEELKMEQEESTKIKENLDR---QILEQSENCMNHKKEIEHLNEANETLQ 1183
+ + + L E+ S+K + DR + E+ ++ + +E EA E L+
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503
Query: 1184 FEMKTLLHEVEQ------------HRVREEALNLELLNKENEFKLWENEAAAFYHDLQMS 1231
K L E+E H + + LE +E + +L E E +LQ +
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-----DELQAT 1558
Query: 1232 SICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISL----LESEIGGLKEQLSAY 1287
LE + L G + + A+ +NE R + E+E+ ++Q +
Sbjct: 1559 EDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 1288 VPLVSSLKEDFNSLE----------HISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSA 1337
L+ D LE ++ ++ Q+++ R +A
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 1338 RENEIVLIPDGVSDLLTLQTRIRAVEKIMME-ELKRRVKQKSLTTESTPYSSLEIATY-- 1394
+ENE +DL+ LQ + A E+ + +L++ + L + + ++L+
Sbjct: 1676 KENE-KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 1395 -PKVENRKKEIELVEENVFDRNSWRKKP--KIRLLMKDIPLDRNVDDQNSKYLKREHRRT 1451
++ ++E+E + N+ + +K + L ++ +R+ +N ++ R+
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 1452 NDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSV 1511
+ +L H + + + S+ +E ++ +L + V
Sbjct: 1795 KELRSKL--------------------HEMEGAVKSKFKSTIAALEAKIA----QLEEQV 1830
Query: 1512 KEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEV 1571
+++ + K+ + L +KL + + ++D +K E K+ + + + +KR +EE
Sbjct: 1831 EQEARE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 1572 EEAVMQQVSINDQMAKNVEEGASS---LDREIP------RRGSE 1606
EE + + ++ + ++E S + RE+ RRG+E
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 107 bits (267), Expect = 3e-22
Identities = 204/1036 (19%), Positives = 418/1036 (39%), Gaps = 150/1036 (14%)
Query: 18 DSHNSPKNSKWLLE--------NLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELM 69
D +N + LLE NL + + K K++ KL + + +S E+ KK +
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL-KNKHESMISELEVRLKKEEKSR 1050
Query: 70 KLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHT 129
+ +E+ R A + + +L+ + + ++
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--------------EELQAAL 1096
Query: 130 SARPTHRSKKNE--RSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLN 187
+ ++KN + E G + L+E L ++ ++ Q ++ E L ++T+L
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 188 KAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAG-EVLYNQCLETIARLESMLSQ-- 244
++ + ++ E +V +LK++L + +A + + + + + L L Q
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 245 ---------KDNIEAKN--LKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSR 293
K +E +N L EL + K V + K+ ++ L++K + E
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 294 MLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKN 353
LND++ + + EVE++ L E + L+ + ++ + +++ QE +
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-------KDVASLSSQLQDTQELLQ---- 1325
Query: 354 KIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHG 413
E+ +KL +S K R LE+ +LQ + L + + +K + LE+H I L +
Sbjct: 1326 --EETRQKLNVSTKLR-QLEEERNSLQ---DQLDEEMEAKQN--LERH--ISTLNIQLSD 1375
Query: 414 EHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEE 473
S ++AL++ + QKE NL + + LE +K ++E+ +V +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 474 NKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQ----------RET 523
+L + + +K +++ K I K E + E+ + E
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 524 HQIKDDIQHLNERYQAMLEQLQS----LGLNPNSFAASVRDLQNENFMLKETCKKEHSEK 579
+ K++++ N+ +A +E L S +G N + S R L+ + +K ++ E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 580 EALREKSKDMNEVLMENACMEFSL-LGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEK 638
+A E +K EV M+ +F L DE + ++ +Q + L E ++ L DE+
Sbjct: 1556 QA-TEDAKLRLEVNMQALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDER 1609
Query: 639 STLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKS-GDLEDCCKLLNDEKNNL 697
+ + + + +K LE + + +D+ I+ IK L+ K E +
Sbjct: 1610 -----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 698 QNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL---FASILVQK 754
+ R + + + E+K +LE + L+E A E+ ++ A + EEL AS L +
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 755 ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELE 814
+ K EAR+A LE L+EEQ G +E + R Q E
Sbjct: 1725 NALQDEKRRLEARIAQLE---EELEEEQ--GNMEAMSDRVRKATQQAEQ----------- 1768
Query: 815 LKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQ 874
L E ++ ++ +LE +N ++ + +H++ G ++
Sbjct: 1769 -----LSNELATERSTAQKNESARQQLERQN--------------KELRSKLHEMEGAVK 1809
Query: 875 IDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEG 934
S+ I +LE+ + + +E+ +Q E SL+Q +
Sbjct: 1810 ------------------SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 935 EKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQ 994
+++ L+ + + E +EQ +K + +QL+ ++ E+ R + LQ
Sbjct: 1852 KEILLQVEDERKMAEQYKEQ---AEKGNARV----KQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 995 AEMIELRQTNQVFQEE 1010
E+ E ++N+ E
Sbjct: 1905 RELDEATESNEAMGRE 1920
Score = 107 bits (266), Expect = 4e-22
Identities = 210/1084 (19%), Positives = 436/1084 (39%), Gaps = 167/1084 (15%)
Query: 38 TKVKSMIK-LIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHA 96
T+ K++++ ++ E + +A EM + + +L E + L E D +L+
Sbjct: 886 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ-QLQAE 944
Query: 97 HKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLRE 156
K M + + + +++ L E T+ + + ++ N ++ R+
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 157 ALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQ 216
L + SD + +E +NL+K++ NK ++ L+ R + E + L++ +
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 217 LKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLE 276
L+ D IA L+ L++K+ +EL + + D + Q L+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKE--------EELQAALARLDDEIAQKNNALK 1111
Query: 277 KIPMLENKIA--------------LAEENSRMLNDQIERTELEVETLRKNLAEMNEER-- 320
KI LE I+ AE+ R L +++E + E+E + A E R
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 321 --DSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEIS----EKHRGMLEK 374
++VL E+ E ++ +++ Q ++ ++ E+ + + +K++ LEK
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 375 SNQNLQLEAENLVQRIASKDHELLEKHTEIERLQT-LMHGEHS----------------- 416
N +L E L Q +H+ + +++ LQ+ GE +
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 417 -----------------NFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELS 459
+ + S LQ Q+L + +++ N++ +L+ L++ S
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNS 1347
Query: 460 KQD-FKEEMQGIVEENKTLHELNFSSTRSLKKQQ---MEISKLKEIKEKLEREFHTSTEE 515
QD EEM+ + + LN + S KK Q + L+E K++ ++E T++
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 516 --------------SNVLQRETHQIKDDIQHLN------ERYQAMLEQLQSLGLNPNSFA 555
N LQ+E + D+ + E+ Q +QL + N +S
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 556 ASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRG 615
A RD KET K S AL E + E+ N ++ + L D +
Sbjct: 1468 ADERDRAEAEAREKET--KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 616 TVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFE- 674
V E L++ K L + + +QL+ + + +Q + LE ++ K +FE
Sbjct: 1526 NVHE-------LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 675 GLRIKSGDLEDCCKLLNDEKNNLQNE-------RSMLISQLEIVEEKLSNLE-------- 719
L+ + E+ + L + + + E R++ + + +E L +LE
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 720 ------KKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLEN 773
K++ L+ + D +++ E A +E+FA+ KEN K S EA L L+
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA---KENEKKAK-SLEADLMQLQE 1694
Query: 774 IVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECE-------- 825
+ + ++ +E E+ + + ++ LQ+ LE + L E E
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 826 ---KLVEASKFSDKVISELESENLMQLIEE---EFLLHRIRKFKMDIHKVCGVLQIDSDG 879
++ +A++ ++++ +EL +E E + L + ++ + +H++ G ++
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK- 1813
Query: 880 GGDNEIKKEEIPISRILDKIE-------SLESSLVKSQEENQQLLVENSVLLGSLQQHQS 932
+ I E I+++ +++E + SL + ++ +++L++ +Q++
Sbjct: 1814 ---STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 933 EGEK-------LKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENR 985
+ EK LK + + E+E + + LQ++ E E N + EV K R
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Query: 986 SKST 989
T
Sbjct: 1931 GNET 1934
Score = 86.7 bits (213), Expect = 5e-16
Identities = 109/520 (20%), Positives = 229/520 (43%), Gaps = 33/520 (6%)
Query: 25 NSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAE 84
N + L+ NL + K + +L+ EE + ++ A+ + E + + RAL E
Sbjct: 1438 NQRQLVSNL---EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
+ A EL +K + + +++ G + E A T + ++ +
Sbjct: 1495 ALE-AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALET-QMEEMKTQL 1548
Query: 145 EESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAE 204
EE E+Q +A +++ + AL Q++ L+ ++ E + K + R L + E E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQ--ARDEQNEEKRRQLQRQLHEY--ETE 1604
Query: 205 IQVEILKESLMQLKADKDAGEV--LYNQCLETIARLESMLSQKDNIEA--KNLKQELTRV 260
++ E + +L K G++ L Q I E + Q ++A K+ ++EL
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 261 VVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEER 320
+D + K+ +K LE + +E+ ++ +LE E L + LA R
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 321 DSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEK---EAEKL--EISEKHRGMLEKS 375
++L +I+++E E+ Q N E + +++ K +AE+L E++ + +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 376 NQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQS 435
+ QLE +N + + SK HE+ + + ++ + + Q+E ++ + +
Sbjct: 1785 SARQQLERQN--KELRSKLHEM--EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 436 QKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEI 495
K + +LK LL ++D + +KE+ + + N + +L R L++ + E
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE---KGNARVKQLK----RQLEEAEEES 1893
Query: 496 SKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNE 535
++ + KL+RE +TE + + RE + +K ++ NE
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 80.5 bits (197), Expect = 4e-14
Identities = 159/822 (19%), Positives = 343/822 (41%), Gaps = 90/822 (10%)
Query: 868 KVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSL 927
KV +LQ+ + E++ +E + + ++ + E+ L + ++++ QL E ++L L
Sbjct: 840 KVKPLLQVTRQ---EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 928 QQHQ---SEGEKLKLEKKTVEQEFENM---REQNVILQKDKVELLEENR----QLRIEVV 977
Q +E E++++ +QE E + E + ++D+ + L+ R Q +++
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 978 NGVEKENRSKSTL----AALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKS 1033
+E+E ++ L +A++ +L V ++N K+ E+ L +SDL +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL--TTN 1014
Query: 1034 SAEDENSVMFHDVLALSNLNLVYEIFFTENMVEK-RALCEHL-----GNLSHLNN---DL 1084
AE+E L + +++ E+ EK R E L G+ S + DL
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 1085 NQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQ 1144
+ L+ KE E L ++ R+D E+ + + LK E HI +L+ +
Sbjct: 1075 QAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIR----ELEGHISDLQEDL 1127
Query: 1145 EESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALN 1204
+ + ++Q + E K E+E ++ T Q E++ ++ V ++AL+
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ-ELRA--KREQEVTVLKKALD 1184
Query: 1205 LELLNKENEFKLWENEAAAFYHDL--QMSSICLA---------LLESKVSELTGVCKILD 1253
E + E + + + A +L Q+ A LE + ++L G ++L
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 1254 DESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEH-ISLLWTKRN 1312
E EH ++ LE+++ L+ + S + L + + L++ + + N
Sbjct: 1245 QAKQ----EVEHKKK---KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 1313 SVVGNGAQ--KDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEEL 1370
G + KDV S S ++ L+ + L + T++R +E+
Sbjct: 1298 EAEGKAIKLAKDVA--------SLSSQLQDTQELLQEETRQKLNVSTKLRQLEE------ 1343
Query: 1371 KRRVKQKSLTTESTPYSSLE--IATYP-KVENRKKEIELVEENV--FDRNSWRKKPKIRL 1425
+R Q L E +LE I+T ++ + KK+++ V + R + +I
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 1426 LMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHA----MICHRS 1481
L + D+ K R + +D V++L +N+ + +S ++
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL--DNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1482 DDSGRYLNYSSELDIE-KELGVDKLELSKSVKEKTE--DDKRRILERLSSDGQKLAILKM 1538
+ S +Y + + E +E L L+++++E E ++ R + L ++ + L K
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK- 1520
Query: 1539 ALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDR 1598
D+ K +KSK+ + + E +K +EE+E+ + ++ N++ +R
Sbjct: 1521 --DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 1599 EIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISRK 1640
++ R + K + + + +L +E + ++K
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Score = 53.5 bits (127), Expect = 5e-06
Identities = 80/358 (22%), Positives = 150/358 (41%), Gaps = 61/358 (17%)
Query: 39 KVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHK 98
K++ +K +E +ADS + E K+ +L +++F R EL A
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--------------ELEDARA 1666
Query: 99 TMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREAL 158
+ E F + S L E +A ER+ ++++ E + L E L
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAA---------ERARKQADLEKEELAEEL 1717
Query: 159 AKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLK 218
A S ++AL + + ++++E +L + Q N + DR +A Q E L L +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 219 A----DKDAGEVLYNQCLE------------------TIARLESMLSQ-KDNIEAK-NLK 254
+ ++ A + L Q E TIA LE+ ++Q ++ +E + K
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 255 QELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLA 314
Q T+ + QKD K+ E + +E++ +AE+ +Q E+ V+ L++ L
Sbjct: 1838 QAATKSLKQKD------KKLKEILLQVEDERKMAEQ----YKEQAEKGNARVKQLKRQLE 1887
Query: 315 EMNEERDSLSVLYHHCLEKISKM--ENEILHVQENAEQLKNKIEKEAEKLEISEKHRG 370
E EE ++ ++ + NE + + NA LK+K+ + E + + G
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNA--LKSKLRRGNETSFVPSRRSG 1943
>MYS2_DICDI (P08799) Myosin II heavy chain, non muscle
Length = 2116
Score = 154 bits (389), Expect = 2e-36
Identities = 283/1315 (21%), Positives = 573/1315 (43%), Gaps = 176/1315 (13%)
Query: 134 THRSKKNERSSEESNGEVQTL-------REALAKMQSDKDALFLQYQESLENLSKMETDL 186
T + K E+S +++ V L +E L M KDAL Q +E + ME++L
Sbjct: 848 TTQKDKLEKSLKDTESNVLDLQRQLKAEKETLKAMYDSKDALEAQKRELEIRVEDMESEL 907
Query: 187 NKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVL---YNQCLE---------- 233
++ + L ++ E +V L+E L + + ++ E L Y + LE
Sbjct: 908 DEKKLALENLQNQKRSVEEKVRDLEEELQEEQKLRNTLEKLKKKYEEELEEMKRVNDGQS 967
Query: 234 -TIARLESM----------LSQKDNIEAKN----------LKQELTRVVVQKDTVLLQYK 272
TI+RLE + L++ + E+K+ L+ EL + V+ D+
Sbjct: 968 DTISRLEKIKDELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKDKS 1027
Query: 273 QCLEKIPMLENKI-----ALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLY 327
+ L + LE ++ ALA E + L + +L+ E E+NE+ +S V
Sbjct: 1028 ELLRQKKKLEEELKQVQEALAAETAAKLAQEAANKKLQGE-----YTELNEKFNS-EVTA 1081
Query: 328 HHCLEKISK-MENEILHV-QENAEQLKNK--IEKEAEKLE-ISEKHRGMLE------KSN 376
+EK K +E++++ V E E+ KN+ +EK+ + L+ + E+ + LE KS
Sbjct: 1082 RSNVEKSKKTLESQLVAVNNELDEEKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSL 1141
Query: 377 QNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQ 436
+L+++ E+ ++ + ++ EL ++E++++ + GE +++ L+A Q S +
Sbjct: 1142 YDLKVKQESDMEALRNQISELQSTIAKLEKIKSTLEGE---VARLQGELEAEQLAKSNVE 1198
Query: 437 KEQRNLALELKYGLLLLKDLELSKQDF----KEEMQGIVEENKTLHELNFSSTRSLKKQQ 492
K+++ + L+L+ L + +KQ K+ Q + E L E N + S +
Sbjct: 1199 KQKKKVELDLEDKSAQLAEETAAKQALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNK 1258
Query: 493 MEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPN 552
+ +K +LE E + L+++ ++ +++H+NE+ + +Q +S
Sbjct: 1259 HLETSFNNLKLELEAE----QKAKQALEKKRLGLESELKHVNEQLEEEKKQKESNEKRKV 1314
Query: 553 SFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDG 612
V +L+++ ++E + + EA +K +++E+ + A + S ++L
Sbjct: 1315 DLEKEVSELKDQ---IEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKT 1371
Query: 613 LRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIE 672
L+ +E++ + + + K L+ +++++ EK++ A+ +
Sbjct: 1372 LQAKNEELRNTAEEAEGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETD 1431
Query: 673 FEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADV 732
+ + + D+ N+ +E+ + I +L E+LS L + +E+
Sbjct: 1432 YRSTKSEL-----------DDAKNVSSEQYVQIKRL---NEELSELRSVLEEADERCNSA 1477
Query: 733 EKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQE 792
K K++A + +E L I + +N K +E + LE VRV + E+ L ++
Sbjct: 1478 IKAKKTAESALESLKDEI----DAANNAKAKAERKSKELE--VRVAELEESL------ED 1525
Query: 793 LDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLV---EASKFSDKVISELESENLMQL 849
VN + FI + E +L+ L E E + E K + K ++LE++ + +
Sbjct: 1526 KSGTVNVE---FIRKKDAEIDDLR-ARLDRETESRIKSDEDKKNTRKQFADLEAK-VEEA 1580
Query: 850 IEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLE--SSLV 907
E + R++K K++ + Q+D++ +I+K + + + L + + E SS
Sbjct: 1581 QREVVTIDRLKK-KLESDIIDLSTQLDTETKSRIKIEKSKKKLEQTLAERRAAEEGSSKA 1639
Query: 908 KSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQ--NVILQKDKVEL 965
+E +Q+ E L L ++ + + K++ E + ++EQ + IL KDK L
Sbjct: 1640 ADEEIRKQVWQEVDELRAQLDSERAALNASEKKIKSLVAEVDEVKEQLEDEILAKDK--L 1697
Query: 966 LEENRQLRI---EVVNGVEKENRSKSTL----AALQAEMIELRQTNQVFQEENGKMLDEK 1018
++ R L + EV + +E+E S+S L L E+ ++++ E+N K+ + K
Sbjct: 1698 VKAKRALEVELEEVRDQLEEEEDSRSELEDSKRRLTTEVEDIKKKYDAEVEQNTKLDEAK 1757
Query: 1019 NSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFT--ENMVEKRALCE---- 1072
L +V L K EDE + A L E F + V+ R+ E
Sbjct: 1758 KKLTDDVDTL---KKQLEDEKKKLNESERAKKRLESENEDFLAKLDAEVKNRSRAEKDRK 1814
Query: 1073 -HLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNA 1131
+ +L LN E + E+ A+ L + I+ + +L + + A+ S
Sbjct: 1815 KYEKDLKDTKYKLNDE-AATKTQTEIGAAK---LEDQIDELRSKLEQEQAKATQADKSKK 1870
Query: 1132 EFSRHIEELKMEQEESTKIKENLD-------------RQILEQSENCMNHKKEIEHLNEA 1178
I+ L+ + E+ KIK L+ R+ +E++E+ + ++ + L E
Sbjct: 1871 TLEGEIDNLRAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQSKRLVEL 1930
Query: 1179 NETLQFEMKTLLHEVEQHRVREEA-LNLELLNKENEFKLWENEAAAFYHDLQMSSICLAL 1237
L+ + L E++ + E+A NL+ E + +L E A D
Sbjct: 1931 E--LEDARRNLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDRSRKR----- 1983
Query: 1238 LESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKED 1297
LE+++ LT +D E AK+ + + ++I E+E LKE + + ++
Sbjct: 1984 LEAEIDALTAQ---VDAEQKAKNQQIKENKKI----ETE---LKEYRKKFGESEKTKTKE 2033
Query: 1298 FNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDL 1352
F +E + + + + Q+ + +E LRKH +EI L+ D + L
Sbjct: 2034 FLVVEKLETDYKRAKKEAADEQQQRLTVENDLRKHL------SEISLLKDAIDKL 2082
Score = 145 bits (365), Expect = 1e-33
Identities = 266/1221 (21%), Positives = 509/1221 (40%), Gaps = 171/1221 (14%)
Query: 47 IEEEADSFARRAEMYYKKRPELM----KLVEEFYRAYRALAERYDHAMGELRHAHKTMPE 102
++ E D R + K + EL+ KL EE + ALA + + K E
Sbjct: 1008 LQSELDDLTVRLDSETKDKSELLRQKKKLEEELKQVQEALAAETAAKLAQEAANKKLQGE 1067
Query: 103 AFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQ 162
Y LN+ S +AR E+S + ++ + L + +
Sbjct: 1068 ------YTELNEKF---------NSEVTAR-----SNVEKSKKTLESQLVAVNNELDEEK 1107
Query: 163 SDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKD 222
++DAL + + L +M+ L + L D + E +E L+ + +L++
Sbjct: 1108 KNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQSTIA 1167
Query: 223 AGEVLYNQCLETIARLESMLSQ----KDNIEAKNLKQELTRVVVQKDTVLLQY---KQCL 275
E + + +ARL+ L K N+E + K EL + K L + KQ L
Sbjct: 1168 KLEKIKSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELD--LEDKSAQLAEETAAKQAL 1225
Query: 276 EKIPM-LENKIA-----LAEENSRMLNDQIERTELEVETLRKNLA-EMNEERDSLSVLYH 328
+K+ LE +++ L+E N++ +N + T +ET NL E+ E+ + L
Sbjct: 1226 DKLKKKLEQELSEVQTQLSEANNKNVNS--DSTNKHLETSFNNLKLELEAEQKAKQALE- 1282
Query: 329 HCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQ 388
+K +E+E+ HV E ++E+E ++ E +EK + LEK L+ + E +
Sbjct: 1283 ---KKRLGLESELKHVNE-------QLEEEKKQKESNEKRKVDLEKEVSELKDQIE---E 1329
Query: 389 RIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKY 448
+ASK K+ + L + + +++ L+ L ++++ E RN A E +
Sbjct: 1330 EVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNE-ELRNTAEEAEG 1388
Query: 449 GLLLLK--------DLELSKQDFKEEMQGIVEENKTLH--ELNFSSTRS----------- 487
L + DLE + ++ +EE V+ K + E ++ ST+S
Sbjct: 1389 QLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELDDAKNVSSE 1448
Query: 488 ----LKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQ 543
+K+ E+S+L+ + E+ + +++ + + +KD+I N +
Sbjct: 1449 QYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAANNAKAKAERK 1508
Query: 544 LQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSL 603
+ L + S+ D + E +K+ +E + LR + E +++ +
Sbjct: 1509 SKELEVRVAELEESLED--KSGTVNVEFIRKKDAEIDDLRARLDRETESRIKS---DEDK 1563
Query: 604 LGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLE 663
+ L V+E Q+ + K L + L +QL T+S KI ++ LE
Sbjct: 1564 KNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIKIEKSKKKLE 1623
Query: 664 KSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVT 723
++L++ + EG K+ D E+ K + E + L+ + + L E+K+ +L +V
Sbjct: 1624 QTLAERRAAEEGSS-KAAD-EEIRKQVWQEVDELRAQLDSERAALNASEKKIKSLVAEVD 1681
Query: 724 NLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQR 783
++E+ D K+ V L V+ E + E + LE+ R L E
Sbjct: 1682 EVKEQLEDEILAKDKLVKAKRALE----VELEEVRDQLEEEEDSRSELEDSKRRLTTEVE 1737
Query: 784 LGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELES 843
K +++ E+++ L + ++ L+ + L E +KL E S++ LES
Sbjct: 1738 DIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQ---LEDEKKKLNE----SERAKKRLES 1790
Query: 844 ENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLE 903
EN E+FL K+D ++ + + + KK E + K+ +
Sbjct: 1791 EN------EDFLA------KLDA-------EVKNRSRAEKDRKKYEKDLKDTKYKLN--D 1829
Query: 904 SSLVKSQEENQQLLVENSV--LLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKD 961
+ K+Q E +E+ + L L+Q Q++ + KKT+E E +N+R Q
Sbjct: 1830 EAATKTQTEIGAAKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEIDNLRAQ------- 1882
Query: 962 KVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQ------EENGKML 1015
+E+ ++++ +EKE R AL+ E+ ELR+T + + E++ +++
Sbjct: 1883 ----IEDEGKIKMR----LEKEKR------ALEGELEELRETVEEAEDSKSEAEQSKRLV 1928
Query: 1016 D-EKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHL 1074
+ E RN+ DAK AED S NL EI + +E+ ++
Sbjct: 1929 ELELEDARRNLQKEIDAKEIAEDAKS------------NLQREIVEAKGRLEEESIAR-- 1974
Query: 1075 GNLSHLNNDLNQEFGVLRKNFEVKE-AENVYLNESIERMDKELLEMDKRLKAAETSNAEF 1133
N L E L + ++ A+N + E+ ++++ EL E K+ +E + +
Sbjct: 1975 TNSDRSRKRLEAEIDALTAQVDAEQKAKNQQIKEN-KKIETELKEYRKKFGESEKTKTKE 2033
Query: 1134 SRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEV 1193
+E+L+ + + + K + +Q L + H EI L +A + LQ + E+
Sbjct: 2034 FLVVEKLETDYKRAKKEAADEQQQRLTVENDLRKHLSEISLLKDAIDKLQRDHDKTKREL 2093
Query: 1194 EQHRVREEALNLELLNKENEF 1214
E E A +E+ K +F
Sbjct: 2094 E----TETASKIEMQRKMADF 2110
Score = 130 bits (328), Expect = 2e-29
Identities = 233/1144 (20%), Positives = 489/1144 (42%), Gaps = 149/1144 (13%)
Query: 239 ESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLND- 297
E + +K+ E LK LT QKD + K + L+ ++ +E + + D
Sbjct: 827 EKEIKEKER-EILELKSNLTDSTTQKDKLEKSLKDTESNVLDLQRQLKAEKETLKAMYDS 885
Query: 298 ------QIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQE---NA 348
Q E+ VE + L E ++L EK+ +E E+ Q+
Sbjct: 886 KDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRDLEEELQEEQKLRNTL 945
Query: 349 EQLKNKIEKEAEKLEISEKHRG----MLEKSNQNLQLEAENLVQRIA--SKDHELLEKHT 402
E+LK K E+E E+++ + LEK LQ E E L + + SKD +LEK T
Sbjct: 946 EKLKKKYEEELEEMKRVNDGQSDTISRLEKIKDELQKEVEELTESFSEESKDKGVLEK-T 1004
Query: 403 EIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQD 462
+ RLQ+ + ++++S + +L Q +K + L +++ L +L+++
Sbjct: 1005 RV-RLQSELD---DLTVRLDSETKDKSELLRQKKKLEEELK-QVQEALAAETAAKLAQEA 1059
Query: 463 FKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRE 522
+++QG E L+E F+S + + S +++ K+ LE + E + ++
Sbjct: 1060 ANKKLQG---EYTELNE-KFNSEVTAR------SNVEKSKKTLESQLVAVNNELDEEKKN 1109
Query: 523 THQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEAL 582
++ + L+ + M +QL+S G E L + K+ S+ EAL
Sbjct: 1110 RDALEKKKKALDAMLEEMKDQLESTG--------------GEKKSLYDLKVKQESDMEAL 1155
Query: 583 REKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLL 642
R + ++ + + ++ +L G E+ L+G ++ Q ++++K + +
Sbjct: 1156 RNQISELQSTIAKLEKIKSTLEG---EVARLQGELEAEQLAKSNVEKQKKKVELDLEDKS 1212
Query: 643 SQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNN------ 696
+QL T + Q + + LE+ LS+ + + K+ + + K L NN
Sbjct: 1213 AQLAEETAAKQALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNKHLETSFNNLKLELE 1272
Query: 697 --------LQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFA 748
L+ +R L S+L+ V E+L +K+ + E++ D+EK+ +Q+EE A
Sbjct: 1273 AEQKAKQALEKKRLGLESELKHVNEQLEEEKKQKESNEKRKVDLEKEVSELKDQIEEEVA 1332
Query: 749 SILVQKENHSNHKHSSEARLANLE-----------------NIVRVLQEEQRLGKVEFEQ 791
S K+ + K+ E+ L ++ ++ EE R E E
Sbjct: 1333 S----KKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAEEAEG 1388
Query: 792 ELDRVVNAQIEM-FILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELES-----EN 845
+LDR ++ + F L+ ++ LE E K V+A K K ++ S ++
Sbjct: 1389 QLDRAERSKKKAEFDLEEAVKNLE-------EETAKKVKAEKAMKKAETDYRSTKSELDD 1441
Query: 846 LMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKE---EIPISRILDKIESL 902
+ E+++ +I++ ++ ++ VL+ ++D ++ IK + E + + D+I++
Sbjct: 1442 AKNVSSEQYV--QIKRLNEELSELRSVLE-EADERCNSAIKAKKTAESALESLKDEIDAA 1498
Query: 903 ESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDK 962
++ K++ ++++L V + L SL+ + KK + E +++R + + +
Sbjct: 1499 NNAKAKAERKSKELEVRVAELEESLEDKSGTVNVEFIRKK--DAEIDDLRARLDRETESR 1556
Query: 963 VELLEENRQLRIEVVN---GVEKENRSKSTL----AALQAEMIEL-----RQTNQVFQEE 1010
++ E+ + R + + VE+ R T+ L++++I+L +T + E
Sbjct: 1557 IKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIKIE 1616
Query: 1011 NGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRAL 1070
K E+ R ++ +K++ E+ ++ +V L + ++ +
Sbjct: 1617 KSKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQEV---DELRAQLDSERAALNASEKKI 1673
Query: 1071 CEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSN 1130
+ + + L E K + K A V L E +++++E + E S
Sbjct: 1674 KSLVAEVDEVKEQLEDEILAKDKLVKAKRALEVELEEVRDQLEEE----EDSRSELEDSK 1729
Query: 1131 AEFSRHIEELK----MEQEESTKI---KENLDRQILEQSENCMNHKKEIEHLNEANETLQ 1183
+ +E++K E E++TK+ K+ L + + + KK++ A + L+
Sbjct: 1730 RRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQLEDEKKKLNESERAKKRLE 1789
Query: 1184 FEMKTLLHEVE-----QHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALL 1238
E + L +++ + R ++ E K+ ++KL N+ AA + I A L
Sbjct: 1790 SENEDFLAKLDAEVKNRSRAEKDRKKYEKDLKDTKYKL--NDEAA---TKTQTEIGAAKL 1844
Query: 1239 ESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDF 1298
E ++ EL ++ AK+ + + ++ LE EI L+ Q+ + L+++
Sbjct: 1845 EDQIDELRSKL----EQEQAKATQADKSKK---TLEGEIDNLRAQIEDEGKIKMRLEKEK 1897
Query: 1299 NSLE 1302
+LE
Sbjct: 1898 RALE 1901
Score = 122 bits (307), Expect = 6e-27
Identities = 253/1244 (20%), Positives = 507/1244 (40%), Gaps = 178/1244 (14%)
Query: 486 RSLKKQQMEISKLKEI-------KEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQ 538
+ +K+++ EI +LK K+KLE+ + ESNVL + Q+K + E +
Sbjct: 828 KEIKEKEREILELKSNLTDSTTQKDKLEKSLKDT--ESNVLDLQ-RQLKAE----KETLK 880
Query: 539 AMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENAC 598
AM + +L V D+++E K + ++K ++ EK +D+ E L E
Sbjct: 881 AMYDSKDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRDLEEELQEE-- 938
Query: 599 MEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILEN 658
LR T++++++ + EE + D +S +S+L+ I + +QK +E
Sbjct: 939 ------------QKLRNTLEKLKKKYEEELEEMKRVNDGQSDTISRLEKIKDELQKEVEE 986
Query: 659 NT--VLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDE---KNNLQNERSMLISQLEIVEE 713
T E+S +E +R++S +L+D L+ E K+ L ++ L +L+ V+E
Sbjct: 987 LTESFSEESKDKGVLEKTRVRLQS-ELDDLTVRLDSETKDKSELLRQKKKLEEELKQVQE 1045
Query: 714 KLS--------------NLEKKVTNLEEKY-------ADVEKDKESAVNQVEELFASILV 752
L+ L+ + T L EK+ ++VEK K++ +Q+ + +
Sbjct: 1046 ALAAETAAKLAQEAANKKLQGEYTELNEKFNSEVTARSNVEKSKKTLESQLVAVNNELDE 1105
Query: 753 QKENHSNHKHSSEARLANLENIVRVLQ----EEQRLGKVEFEQELD-RVVNAQIEMFILQ 807
+K+N + +A A LE + L+ E++ L ++ +QE D + QI LQ
Sbjct: 1106 EKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISE--LQ 1163
Query: 808 NCIEELELKNFVLL---------TECEKLVEASKFSDKVISELESENLM-QLIEEEFLLH 857
+ I +LE L E E+L +++ K EL+ E+ QL EE
Sbjct: 1164 STIAKLEKIKSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELDLEDKSAQLAEETAAKQ 1223
Query: 858 RIRKFKMDIHKVCGVLQI------DSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQE 911
+ K K + + +Q + + D+ K E + + K+E K
Sbjct: 1224 ALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNKHLETSFNNL--KLELEAEQKAKQAL 1281
Query: 912 ENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVE-----QEFENMREQNVILQKDKVELL 966
E ++L +E+ + + Q + + +K EK+ V+ E ++ E+ V +K E
Sbjct: 1282 EKKRLGLESELKHVNEQLEEEKKQKESNEKRKVDLEKEVSELKDQIEEEVASKKAVTEAK 1341
Query: 967 EENR----QLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLC 1022
+ +++ + + V ++S L LQA+ ELR T + E G++ + S
Sbjct: 1342 NKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAE---EAEGQLDRAERSKK 1398
Query: 1023 RNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNN 1082
+ DL++A + E+E + A+ Y +E K E + LN
Sbjct: 1399 KAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELDDAKNVSSEQYVQIKRLNE 1458
Query: 1083 DLNQEFGVLRKNFE--------VKEAENVY--LNESIERMDKELLEMDKRLKAAETSNAE 1132
+L++ VL + E K AE+ L + I+ + + +++ K E AE
Sbjct: 1459 ELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAANNAKAKAERKSKELEVRVAE 1518
Query: 1133 FSRHIEE---------LKMEQEESTKIKENLDRQI---LEQSENCMNHKKEIEHLNEANE 1180
+E+ ++ + E ++ LDR+ ++ E+ N +K+ L E
Sbjct: 1519 LEESLEDKSGTVNVEFIRKKDAEIDDLRARLDRETESRIKSDEDKKNTRKQFADLEAKVE 1578
Query: 1181 TLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLES 1240
Q E+ T+ R++++ L ++++ + D + S
Sbjct: 1579 EAQREVVTI------DRLKKK-LESDIIDLSTQL------------DTETKSRIKIEKSK 1619
Query: 1241 KVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNS 1300
K E T + +E S+K+ + E +++ E+ L+ QL + +++ ++ S
Sbjct: 1620 KKLEQTLAERRAAEEGSSKAADEEIRKQVWQ----EVDELRAQLDSERAALNASEKKIKS 1675
Query: 1301 LEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIR 1360
L A+ D V E E+EI+ D L R
Sbjct: 1676 LV----------------AEVDEVKEQL----------EDEIL-----AKDKLVKAKRAL 1704
Query: 1361 AVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKK 1420
VE +EE++ +++++ + S + T + +K + E+ + D +
Sbjct: 1705 EVE---LEEVRDQLEEEEDSRSELEDSKRRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLT 1761
Query: 1421 PKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHR 1480
+ L K + ++ +++ + KR D + +L + E + S D
Sbjct: 1762 DDVDTLKKQLEDEKKKLNESERAKKRLESENEDFLAKL--DAEVKNRSRAEKDRKKYEKD 1819
Query: 1481 SDDSGRYLNYSSELDIEKELGVDKLELS-KSVKEKTEDDKRRILERLSSDGQ---KLAIL 1536
D+ LN + + E+G KLE ++ K E ++ + + S ++ L
Sbjct: 1820 LKDTKYKLNDEAATKTQTEIGAAKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEIDNL 1879
Query: 1537 KMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSL 1596
+ ++D K +K K+ + E E ++ +EE E++ + + +E+ +L
Sbjct: 1880 RAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQSKRLVELELEDARRNL 1939
Query: 1597 DREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNKVKNRISRK 1640
+EI + + K + + I +L EE+ + + SRK
Sbjct: 1940 QKEIDAKEIAEDAKSNLQ-REIVEAKGRLEEESIARTNSDRSRK 1982
Score = 71.6 bits (174), Expect = 2e-11
Identities = 140/724 (19%), Positives = 318/724 (43%), Gaps = 101/724 (13%)
Query: 5 SESESRRLYSWWWDSHNSPKNSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKK 64
+E++ R S D+ N ++ L + ++++S+++ +E +S A +A+ +
Sbjct: 1428 AETDYRSTKSELDDAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNS-AIKAKKTAES 1486
Query: 65 RPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSA-----YYILNDDSPCG 119
E +K + +A AER + E+R A + E+ + + +I D+
Sbjct: 1487 ALESLKDEIDAANNAKAKAERKSKEL-EVRVAE--LEESLEDKSGTVNVEFIRKKDAEID 1543
Query: 120 SLGPDAESHTSAR-PTHRSKKNERSS--------EESNGEVQTLREALAKMQSDKDALFL 170
L + T +R + KKN R EE+ EV T+ K++SD L
Sbjct: 1544 DLRARLDRETESRIKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLST 1603
Query: 171 QYQESLENLSKMETDLNKAQNN------ARGLDDRASEAEIQVEILKESLMQLKADKDAG 224
Q ++ K+E K + A +A++ EI+ ++ +E + +L+A D+
Sbjct: 1604 QLDTETKSRIKIEKSKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQE-VDELRAQLDSE 1662
Query: 225 EVLYNQCLETIARLESMLSQ-KDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLEN 283
N + I L + + + K+ +E + L ++ ++V K + ++ ++ +++ E+
Sbjct: 1663 RAALNASEKKIKSLVAEVDEVKEQLEDEILAKD--KLVKAKRALEVELEEVRDQLEEEED 1720
Query: 284 KIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILH 343
+ E++ R L EVE ++K Y +E+ +K++
Sbjct: 1721 SRSELEDSKRRLT-------TEVEDIKKK--------------YDAEVEQNTKLDEAKKK 1759
Query: 344 VQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNL--QLEAENLVQRIASKDHELLEKH 401
+ ++ + LK ++E E +KL SE+ + LE N++ +L+AE + A KD + EK
Sbjct: 1760 LTDDVDTLKKQLEDEKKKLNESERAKKRLESENEDFLAKLDAEVKNRSRAEKDRKKYEK- 1818
Query: 402 TEIERLQTLMHGEHSNFIQIE--------------SALQALQKLYSQSQKEQRNLALELK 447
+++ + ++ E + Q E S L+ Q +Q+ K ++ L E+
Sbjct: 1819 -DLKDTKYKLNDEAATKTQTEIGAAKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEID 1877
Query: 448 YGLLLLKD---LELSKQDFKEEMQGIVEE-NKTLHELNFSSTRSLKKQQMEISKLKEIKE 503
++D +++ + K ++G +EE +T+ E S + + + +++ +L++ +
Sbjct: 1878 NLRAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQSKRLVELELEDARR 1937
Query: 504 KLEREF---HTSTEESNVLQRETHQIKDDIQH------LNERYQAMLE-QLQSLGLNPNS 553
L++E + + + LQRE + K ++ ++R + LE ++ +L ++
Sbjct: 1938 NLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDRSRKRLEAEIDALTAQVDA 1997
Query: 554 FAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGL 613
+ EN + ET KE+ +K EK+K +++E L
Sbjct: 1998 EQKAKNQQIKENKKI-ETELKEYRKKFGESEKTKTKEFLVVEK----------------L 2040
Query: 614 RGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSL---SDAK 670
K ++ Q+++ + ++ LS++ ++ +++ K+ ++ ++ L + +K
Sbjct: 2041 ETDYKRAKKEAADEQQQRLTVENDLRKHLSEISLLKDAIDKLQRDHDKTKRELETETASK 2100
Query: 671 IEFE 674
IE +
Sbjct: 2101 IEMQ 2104
Score = 45.1 bits (105), Expect = 0.002
Identities = 58/291 (19%), Positives = 118/291 (39%), Gaps = 29/291 (9%)
Query: 1360 RAVEKIMMEELK-RRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWR 1418
RA + +EE + +R+ + ++ + Y + ++++N+ ++
Sbjct: 747 RAGQLARIEEAREQRISEIIKAIQAATRGWIARKVYKQAREHTVAARIIQQNLRAYIDFK 806
Query: 1419 KKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMIC 1478
P +L K PL + + ++E + +LEL N ++ ++
Sbjct: 807 SWPWWKLFSKARPLLKR------RNFEKEIKEKEREILELKSNLTDSTTQKDKLEKSL-- 858
Query: 1479 HRSDDSGRYLNYSSELDIEKE-----------LGVDKLELSKSVK--EKTEDDKRRILER 1525
D L+ +L EKE L K EL V+ E D+K+ LE
Sbjct: 859 --KDTESNVLDLQRQLKAEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALEN 916
Query: 1526 LSSDG----QKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSI 1581
L + +K+ L+ LQ+ +K T +K K+ + E E +KR + + + + I
Sbjct: 917 LQNQKRSVEEKVRDLEEELQEEQKLRNTLEKLKKKYEEELEEMKRVNDGQSDTISRLEKI 976
Query: 1582 NDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNK 1632
D++ K VEE S E +G + +++ + + + ++L E +K
Sbjct: 977 KDELQKEVEELTESFSEESKDKGVLEKTRVRLQ-SELDDLTVRLDSETKDK 1026
>GCC2_HUMAN (Q8IWJ2) GRIP and coiled-coil domain-containing protein 2
(Golgi coiled coil protein GCC185) (CTCL tumor antigen
se1-1) (CLL-associated antigen KW-11)
Length = 1583
Score = 154 bits (388), Expect = 3e-36
Identities = 333/1618 (20%), Positives = 648/1618 (39%), Gaps = 267/1618 (16%)
Query: 138 KKNERSSEESNGEVQTLREAL----AKMQSDKDALFLQYQESLENLSKMETDLNKAQNNA 193
K+ E+S E++ L+ L +K DK L Q +E++ ++ L K QNN+
Sbjct: 17 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQL-KFQNNS 75
Query: 194 RGLDDRASEAEIQVEILK----ESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIE 249
+D + + ++E ++ E ++ L+ DA ++ ET+ +L++++
Sbjct: 76 ---EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATT---DEKKETVTQLQNIIEANSQHY 129
Query: 250 AKNL--------------KQELTRVVVQKDTVLLQYKQCLEKIPML-ENKIALAEENSRM 294
KN+ ++E+ ++ Q + +++ + K+ L EN + E + +
Sbjct: 130 QKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKN 189
Query: 295 LNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNK 354
+ ++ E E+E LRK + N++ S+L + ++ H+++ ++L+++
Sbjct: 190 IQ---KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQ 246
Query: 355 IEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELL----EKHTEIERLQTL 410
+++ + LE Q+++ E + + + K +ELL E+ IE+L++
Sbjct: 247 HSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE 306
Query: 411 MHGEHSNF-IQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQG 469
+ G + F +E + +Q L Q QKE L L D E K E+QG
Sbjct: 307 LAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL------NETFLSDSEKEKLTLMFEIQG 360
Query: 470 IVEENKTLHE------LNFSSTRSLKKQQMEI--SKLKEIKEKLEREFHTSTEESNVLQR 521
+ E+ + L + LN+ S R + MEI ++L E K+ +EF + ++
Sbjct: 361 LKEQCENLQQEKQEAILNYESLREI----MEILQTELGESAGKISQEFESMKQQQ---AS 413
Query: 522 ETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEA 581
+ H+++ ++ A+LE + L N S ++L E E K EK
Sbjct: 414 DVHELQQKLRTAFTEKDALLETVNRL-QGENEKLLSQQELVPE----LENTIKNLQEKNG 468
Query: 582 LREKSKDMNEVLMENACMEFSLLGLNDELDG----LRGTVKEIQQFCQVLQEEKSILADE 637
+ S + +++ +E + L +E D L+ + +E+ F + + E+ ++ +
Sbjct: 469 VYLLSLSQRDTMLKE--LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 526
Query: 638 KSTLLSQLQIITESMQKILE-----NNTVLEKSLSDAKIE--FEGLRIKSGDLEDC---C 687
+ +Q +E QK+ E T+ EK +D K+E +++ S D E
Sbjct: 527 GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 586
Query: 688 KLLNDEKNNLQNERSMLISQLE---------IVEEKLSNLEKKVTNLEEKYADVEKDKES 738
K L +E N L +E+ L LE I++E ++ LEKK+ + E+ ++ K E+
Sbjct: 587 KSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLEN 646
Query: 739 AVNQVEELFASILVQ---KENHSNHKHSSEARLANLENIVRVLQE-EQRLGKVEFEQELD 794
QV++LF + KE S SE + ++V VLQ + L K+
Sbjct: 647 --EQVQKLFVKTQLYGFLKEMGSEVSEDSEEK-----DVVNVLQAVGESLAKIN------ 693
Query: 795 RVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEF 854
E K + EK++E +K I L+ E+++Q E +
Sbjct: 694 -------------------EEKCNLAFQRDEKVLEL----EKEIKCLQEESVVQCEELKS 730
Query: 855 LLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQ 914
LL + K+ + K EI+ E+ E+L+S L++ + N+
Sbjct: 731 LLRDYEQEKVLLRKEL------------EEIQSEK----------EALQSDLLEMKNANE 768
Query: 915 QLLVENSVLL---GSLQQHQSEGEKLKLEKKTVEQEFENM-----------REQNVILQK 960
+ +EN LL + Q S+ E ++K +E EN+ R +IL K
Sbjct: 769 KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLK 828
Query: 961 DKV---------------ELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQ 1005
D + EL E+ L E EK N+ K + E+ R+ Q
Sbjct: 829 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 888
Query: 1006 VFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMV 1065
+EE + EK+ L ++ DL S NL L YE + V
Sbjct: 889 TVKEELESLRSEKDQLSASMRDLIQGAES--------------YKNLLLEYEKQSEQLDV 934
Query: 1066 EKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKA 1125
EK E N H DL ++ E ++N L IE + ++ ++
Sbjct: 935 EK----ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 990
Query: 1126 AETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQ-- 1183
+ + A + +E K+++E+ K ++ E KK+++ + E ++
Sbjct: 991 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1050
Query: 1184 FEMKTLLH-EVEQHRVREEALNLELLNKEN-------EFKLWENEAAAFYHDLQMSSICL 1235
+ TL++ E+ + + LN +L NK N E K+ + + ++ +
Sbjct: 1051 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1110
Query: 1236 ALLESKVSELTG-VCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAY-VPLVSS 1293
E K +++ + K + + +K E +H+ + + L+ E+ ++Q+ Y + L
Sbjct: 1111 QQYEEKNTKIKQLLVKTKKELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEI 1169
Query: 1294 LKEDFNSLEHISLLWTKRNSVVGNGAQKDVVI-ETCLRKHSHQSARENEIVLIPDGVSDL 1352
E EH+ + + Q+ + E C + Q+ +E V ++
Sbjct: 1170 TSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNV 1229
Query: 1353 LTLQ-------------TRIRAVEKIMMEELKRRVK--QKSL--------TTESTPYSSL 1389
L Q + R ++++++LK +++ Q +L T +S + L
Sbjct: 1230 LKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLL 1289
Query: 1390 EIATYPKVENRKKEIELVEE--NVFDRNSWRKK---PKIRLLMKDIPLDRNVDDQNSKYL 1444
E E KE EL E+ ++ N K + L + RN ++L
Sbjct: 1290 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1349
Query: 1445 KREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDK 1504
+ EHR+T + + + E + S S + L D+
Sbjct: 1350 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDL------PL 1403
Query: 1505 LELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETV 1564
L++ +E+ E + E +SS + +L+ L ETK E
Sbjct: 1404 LDMHTVTREEGEGMETTDTESVSS----ASTYTQSLEQLLNSPETK----------LEPP 1449
Query: 1565 KRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGS---EQIGKLQFEVQNIQ 1619
H E +E ++Q++S + A ++ + L RE + EQI L+ E++ ++
Sbjct: 1450 LWHAEFTKEELVQKLSSTTKSADHL----NGLLRETEATNAILMEQIKLLKSEIRRLE 1503
Score = 118 bits (296), Expect = 1e-25
Identities = 281/1349 (20%), Positives = 542/1349 (39%), Gaps = 225/1349 (16%)
Query: 351 LKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIA------SKDHELLEKHTEI 404
+K ++E K+ + K LE+S+ N E ENL + S+D L+K E
Sbjct: 1 MKQEVEDSVTKMGDAHKE---LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLE- 56
Query: 405 ERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFK 464
E + T + Q S ++KL + +K + ++ Y L K L+ + + K
Sbjct: 57 EAMNTQLELSEQLKFQNNSE-DNVKKLQEEIEKIRPGFEEQILY---LQKQLDATTDEKK 112
Query: 465 E---EMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQR 521
E ++Q I+E N ++ N +S Q E+ +LK I ++ +E E S
Sbjct: 113 ETVTQLQNIIEANSQHYQKNINSL------QEELLQLKAIHQEEVKELMCQIEAS----- 161
Query: 522 ETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEA 581
+ + +I LNE + +++Q + AS +++Q KK E E
Sbjct: 162 -AKEHEAEINKLNELKENLVKQCE----------ASEKNIQ----------KKYECELEN 200
Query: 582 LREKSKDMNE-------VLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSIL 634
LR+ + + N+ +L EN +E + N+++ L T+KE L+ + SIL
Sbjct: 201 LRKATSNANQDNQICSILLQENTFVEQVV---NEKVKHLEDTLKE-------LESQHSIL 250
Query: 635 ADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEK 694
DE T ++ L++ E + +++ E+ D + + L + + + L E
Sbjct: 251 KDEV-TYMNNLKLKLEMDAQHIKDEFFHERE--DLEFKINELLLAKEEQGCVIEKLKSEL 307
Query: 695 NNLQNERSMLISQLEIVEEKLSNL-EKKVTNLEEKY-ADVEKDKESAVNQVEELFASILV 752
L + + Q + L +K+++ L E + +D EK+K + + +++ L
Sbjct: 308 AGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKE---- 363
Query: 753 QKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEE 812
Q EN K + +L I+ +LQ E + QE + + Q + + E
Sbjct: 364 QCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA------SDVHE 417
Query: 813 LELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGV 872
L+ K TE + L+E ++ L+ EN +L+ ++ L+ + ++ + GV
Sbjct: 418 LQQKLRTAFTEKDALLET-------VNRLQGEN-EKLLSQQELVPELENTIKNLQEKNGV 469
Query: 873 LQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQS 932
+ S D +K+ E I+ + ++ + + L S EE + + +
Sbjct: 470 YLL-SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEE-----------MDNFHKKCE 517
Query: 933 EGEKLKLEK-KTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLA 991
E+L LE K VEQ + EL ++ +L + +++++++ L
Sbjct: 518 REERLILELGKKVEQTIQY-----------NSELEQKVNELTGGLEETLKEKDQNDQKLE 566
Query: 992 ALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSN 1051
L +M L + +V E + +E N L E + D+
Sbjct: 567 KLMVQMKVLSEDKEVLSAEVKSLYEENNKL--------------SSEKKQLSRDL----- 607
Query: 1052 LNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIER 1111
E+F ++ E L EH+ L + +E L K E ++ + +++ +
Sbjct: 608 -----EVFLSQK--EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG 660
Query: 1112 MDKELLEMDKRLKAAETS-NAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKK 1170
KE+ +E S ++E + L+ E KI E ++ E + +K
Sbjct: 661 FLKEM--------GSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEK 712
Query: 1171 EIEHLNEANETLQFEMKTLLHEVEQHRV-----------REEALNLELLNKE--NEFKLW 1217
EI+ L E + E+K+LL + EQ +V +EAL +LL + NE
Sbjct: 713 EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRL 772
Query: 1218 ENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMR----EIISLL 1273
EN+ +Q+ + +S++ C I + E+ LE + +R E+I L
Sbjct: 773 ENQNLL----IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLK 828
Query: 1274 ESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHS 1333
+S L + S +SS+KE +E++ ++ + K ++ +K
Sbjct: 829 DS----LAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKI----NKIKLVAVKAKKEL 880
Query: 1334 HQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIAT 1393
S +E QT +E + E+ + + L + Y +L +
Sbjct: 881 DSSRKET---------------QTVKEELESLRSEKDQLSASMRDLIQGAESYKNL-LLE 924
Query: 1394 YPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKR-EHRRTN 1452
Y K ++ + ++E N F+ R + R L ++ N L R E ++N
Sbjct: 925 YEK-QSEQLDVEKERANNFEH---RIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 980
Query: 1453 DHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVK 1512
+LE+ + E + A VD + + + +++ ++ +EL V +L+ K
Sbjct: 981 AKLLEV-QILEVQRAKA-MVDKELEAEKLQKEQKIKEHATTVNELEELQV-QLQKEKKQL 1037
Query: 1513 EKTEDDKRRILERLSSDGQKLAILKMALQDLKK--KTETKKKSKQGNDIE---------- 1560
+KT + LE + D Q+ ++ M + D ++ K +K + + N IE
Sbjct: 1038 QKTMQE----LELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1093
Query: 1561 --YETVKRHIEEVEEAVMQ----QVSINDQMAKNVEEGASSLDREIPR--RGSEQIGKLQ 1612
ET++ I ++ +V Q I + K +E A S E + G+L+
Sbjct: 1094 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE 1153
Query: 1613 FEVQNIQYILLKLAEENNNKVKNRISRKT 1641
Q ++ ++LAE + K K KT
Sbjct: 1154 ASQQQVEVYKIQLAEITSEKHKIHEHLKT 1182
Score = 115 bits (287), Expect = 1e-24
Identities = 203/1095 (18%), Positives = 473/1095 (42%), Gaps = 158/1095 (14%)
Query: 144 SEESNGEVQTLREALAKMQS------DKDALFLQYQESLENLSKMETDLNKAQNNARG-L 196
+EE + + L+ + +M + ++ L L+ + +E + ++L + N G L
Sbjct: 492 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 551
Query: 197 DDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNI--EAKNLK 254
++ E + + L++ ++Q+K + EVL A ++S+ + + + E K L
Sbjct: 552 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS-------AEVKSLYEENNKLSSEKKQLS 604
Query: 255 QELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELE--------- 305
++L + QK+ V+L+ E I LE K+ L E LN +E +++
Sbjct: 605 RDLEVFLSQKEDVILK-----EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLY 659
Query: 306 --VETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLE 363
++ + ++E +EE+D ++VL E ++K+ N E+ +++ + LE
Sbjct: 660 GFLKEMGSEVSEDSEEKDVVNVL-QAVGESLAKI---------NEEKCNLAFQRDEKVLE 709
Query: 364 ISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIES 423
+ ++ + + E+S ++ E L + + E + E+E +Q+ S+ +++++
Sbjct: 710 LEKEIKCLQEES----VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 765
Query: 424 ALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFK------EEMQGIVEENKT- 476
A + +++ E +NL ++++ E+ + K E ++ ++E+ +
Sbjct: 766 ANE-------KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR 818
Query: 477 -----LHELNFSSTRSLKKQQMEISKLKEIKE---KLEREFHTSTEESNVLQRETHQIKD 528
L L S +S + +S +KE++E LE+E E+ N ++ + K
Sbjct: 819 DRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 878
Query: 529 DIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKD 588
++ + Q + E+L+SL + +AS+RDL + S K L E K
Sbjct: 879 ELDSSRKETQTVKEELESLRSEKDQLSASMRDL----------IQGAESYKNLLLEYEKQ 928
Query: 589 MNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQII 648
++ +E ++ L ++ C+ + + L TL S +++
Sbjct: 929 SEQLDVEKERAN----NFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL 984
Query: 649 TESMQKILENNTVLEKSLSDAKIEFEGLRIKS-----GDLEDCCKLLNDEKNNLQNERSM 703
+ ++ +++K L K++ E +IK +LE+ L EK LQ
Sbjct: 985 EVQILEVQRAKAMVDKELEAEKLQKE-QKIKEHATTVNELEELQVQLQKEKKQLQK---- 1039
Query: 704 LISQLEIVE---EKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNH 760
+ +LE+V+ ++ + + ++ + E ++ + + N++E+L I +QK+
Sbjct: 1040 TMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK---- 1095
Query: 761 KHSSEARLANLENIVRVLQEEQRLGK---VEFEQELDRVVNAQIEMFIL----------- 806
+ + + + +L++ V+ +E+ K V+ ++EL A+ + IL
Sbjct: 1096 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEAS 1155
Query: 807 QNCIEELELKNFVLLTECEKLVEASKFS-----------DKVISELESENLMQLIEEEFL 855
Q +E +++ + +E K+ E K S + ++ L+ E E+ +
Sbjct: 1156 QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV 1215
Query: 856 LHRIRKFKMDIHKVC------GVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKS 909
+K+ +H V + Q +++ G E + E+ I ++ K++ +++L +
Sbjct: 1216 TSEFESYKVRVHNVLKQQKNKSMSQAETE-GAKQEREHLEMLIDQLKIKLQDSQNNLQIN 1274
Query: 910 QEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKV----EL 965
E Q L E+ L L++H ++ ++ + ++ +++ +N++++ + +L
Sbjct: 1275 VSELQTLQSEHDTL---LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1331
Query: 966 LEENRQLR---IEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLC 1022
+N LR + V +++E+R T+ LQ ++ ++ Q+FQ +N S
Sbjct: 1332 TSQNEVLRNSFRDQVRHLQEEHR--KTVETLQQQLSKMEA--QLFQLKNEPTTRSPVSSQ 1387
Query: 1023 RNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNN 1082
+++ +L++ +++ D + H V + E TE++ + L L
Sbjct: 1388 QSLKNLRERRNT--DLPLLDMHTVTREEGEGM--ETTDTESVSSASTYTQSLEQL----- 1438
Query: 1083 DLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKM 1142
LN L E L + + K ++ L+ E +NA +E++K+
Sbjct: 1439 -LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAIL---MEQIKL 1494
Query: 1143 EQEESTKIKENLDRQ 1157
+ E +++ N +R+
Sbjct: 1495 LKSEIRRLERNQERE 1509
Score = 95.1 bits (235), Expect = 1e-18
Identities = 146/701 (20%), Positives = 293/701 (40%), Gaps = 64/701 (9%)
Query: 139 KNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLD- 197
K ++ + S E QT++E L ++S+KD L ++ ++ + L + + + LD
Sbjct: 875 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDV 934
Query: 198 --DRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQ 255
+RA+ E ++E L QL+ E + + + +AR+E++ S +E + L+
Sbjct: 935 EKERANNFEHRIEDLTR---QLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 991
Query: 256 ELTRVVVQK--DTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNL 313
+ + +V K + LQ +Q +++ N++ + + Q+++T E+E ++K+
Sbjct: 992 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1051
Query: 314 AE---MNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRG 370
+ MN E L +K++ N+I E L+ +I+ + +K E ++
Sbjct: 1052 QQTTLMNMEIADYERLMKELNQKLTNKNNKI-------EDLEQEIKIQKQKQETLQEEIT 1104
Query: 371 MLEKSNQNLQLEAENLVQRIASKDHELLE-KHTEIER--LQTLMHGE-HSNFIQIESALQ 426
L+ S Q + + + Q + EL + K E + LQ + GE ++ Q+E
Sbjct: 1105 SLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKI 1164
Query: 427 ALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTR 486
L ++ S+ K +L + L + +EE + E T+ S
Sbjct: 1165 QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV----TSEFE 1220
Query: 487 SLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQS 546
S K + + K ++ K + E + +E L+ Q+K +Q Q + +LQ+
Sbjct: 1221 SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQT 1280
Query: 547 LGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEAL-----------REKSKDMNEVLME 595
L ++ L+ N ML+ET KE +E L E ++ ++++ +
Sbjct: 1281 LQSEHDTL------LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1334
Query: 596 NACMEFSLLGLNDELDGL----RGTVKEIQQFCQVLQEEKSILADEKST--------LLS 643
N + S D++ L R TV+ +QQ ++ + L +E +T L
Sbjct: 1335 NEVLRNS---FRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLK 1391
Query: 644 QLQIITESMQKILENNTVL-EKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERS 702
L+ + +L+ +TV E+ + E + S + +LLN + L+
Sbjct: 1392 NLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLW 1451
Query: 703 MLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKH 762
E + +KLS+ K +L + E + Q++ L + I + N K
Sbjct: 1452 HAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKS 1511
Query: 763 SSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEM 803
+ ANLE + VL + L + L V+N +++
Sbjct: 1512 A-----ANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQL 1547
>GOA4_HUMAN (Q13439) Golgi autoantigen, golgin subfamily A member 4
(Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (72.1
protein)
Length = 2230
Score = 152 bits (384), Expect = 7e-36
Identities = 260/1366 (19%), Positives = 562/1366 (41%), Gaps = 149/1366 (10%)
Query: 138 KKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLEN----LSKMETDLNK----- 188
K E+ E+ + + ++E L K D++A + ++ LEN LS+ E N
Sbjct: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEA---KLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 189 AQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVL------YNQCLETIARLESML 242
AQ N+ G+ D S E + ESL ++ ++ +V+ NQ E + + +
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHR-RELNDVISIWEKKLNQQAEELQEIHEIQ 1065
Query: 243 SQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERT 302
Q+ E LKQ++ +K+ + ++I L+ + + L +Q+++
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKE-------EMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
Query: 303 ELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKL 362
V +L ++ ++ + L V + L++ + ++ +++ ++ AE+ K K+ + KL
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKL 1178
Query: 363 EISEKHRGML----EKSNQNLQ---LEAENLVQRIASKDHELLEKHTEIERLQTLMHGEH 415
+ +++ L EKSN++L+ LE + L + +A ++ ++ + L+ +
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA------IQLDICCKKTEALLEAKT 1232
Query: 416 SNFIQIESA-LQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGI-VEE 473
+ I I S+ A+ S Q + L + +LE + EE + +
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF 1292
Query: 474 NKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHL 533
+ H+L +K + +I L KE L++E + ++ + Q+K ++
Sbjct: 1293 QQATHQLE-EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSEN 1351
Query: 534 NERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVL 593
M E+L+ + +S + + DL + +KE + ++ ++ E+L
Sbjct: 1352 INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
Query: 594 MENACMEFSLLGLNDE-LDGLRGTVKEIQQFCQVLQEEKSILADEKST---LLSQLQIIT 649
+ + F + L+ E + L +F + ++ +S ++T L QL++ +
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 650 ESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLE 709
+ + E +L++ L F+ L+ G++ED + +++NL+ E +++
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLK---GEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 710 IVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLA 769
+E+ ++ ++ +L E + + K+ ++ + E N +E ++
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 770 NLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVE 829
LEN V ++ E K E E V + + E+ L++ +E KL E
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES---------ESAAKLAE 1639
Query: 830 ASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEE 889
+ +++ I+ ++ + L Q+ E+E ++K L + ++++ E
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKE------EQYKKGTESHLSEL--------NTKLQERE 1685
Query: 890 IPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEF- 948
+ + +K++S+ESS +++ L+V S + Q E + +KT E++
Sbjct: 1686 REVHILEEKLKSVESS------QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
Query: 949 ---ENMREQNVILQK---DKVELLEENRQLR-------IEVVNGVEKENRSKSTLAALQA 995
N+ E+ +LQ+ +K E + + ++R I++ + K++ +S + LQ
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 996 EMIELRQ-----TNQVFQEENGK-MLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLAL 1049
E+ E + Q ++E GK + K +L D++ E ++ + L
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859
Query: 1050 SNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESI 1109
+ + + M E + E L L ++ N+ +L +N E K ++ + +
Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDG-RNKPTELLEENTEEKSKSHLVQPKLL 1918
Query: 1110 ERMDKELLEMDKRLKAAETSNAEFSRHI----EELKMEQEESTKIKENLDRQILEQSENC 1165
M+ + +++ +L AE + + I ++L+M ++E + E L ++ ++ E
Sbjct: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK 1978
Query: 1166 MNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFY 1225
+ ++E L N TL K L+ E ++E LE+ KE K E EA
Sbjct: 1979 IKQEQEDLELKH-NSTL----KQLMREFNTQLAQKEQ-ELEMTIKETINKAQEVEA---- 2028
Query: 1226 HDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLS 1285
LLES E + K + ++ + EI+ E E
Sbjct: 2029 ----------ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEE--------- 2069
Query: 1286 AYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLI 1345
+ + +++ LE + + ++ N +V I Q+ + LI
Sbjct: 2070 ----MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL------QTQLAQKTTLI 2119
Query: 1346 PDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEI-ATYPKVENRKKEI 1404
D + +I +E + LK+ K TT TPY + T + E
Sbjct: 2120 SDSKLKEQEFREQIHNLE----DRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEF 2175
Query: 1405 ELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRR 1450
E + + +F+ R+ + ++ + + DDQ K L+RE R
Sbjct: 2176 EYLRKVLFEYMMGRETKTMAKVITTVL--KFPDDQTQKILEREDAR 2219
Score = 138 bits (348), Expect = 1e-31
Identities = 356/1779 (20%), Positives = 740/1779 (41%), Gaps = 327/1779 (18%)
Query: 98 KTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTH----RSKKNERSSEESNGEVQT 153
K +P+ P + + +++P P E TS + R K+ E + +Q+
Sbjct: 246 KPLPQLEPQAEVFT-KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS 304
Query: 154 LREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKES 213
+E + S+K+AL Q E L+ L K++ DL+ A+ ++ Q+ K
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIK-DLHMAEK---------TKLITQLRDAKNL 354
Query: 214 LMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQ 273
+ QL+ DK G V+ ET ++ L K+ E L+ + ++ Q + L + K+
Sbjct: 355 IEQLEQDK--GMVI----AETKRQMHETLEMKEE-EIAQLRSRIKQMTTQGEE-LREQKE 406
Query: 274 CLEKIPMLENKIALA-----EENSRMLNDQ-------IERT-ELEVETLRKNLAEMNEER 320
E+ E + AL+ EE R L + IE+T E E +L++ L+ + +E
Sbjct: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE- 465
Query: 321 DSLSVLYHHCLEKISKMENEILHVQENA---EQLKNKIE------KEAEKLEISEKHRGM 371
+ V+ E+I+K++ LH +E A ++L K++ +E K+ + +
Sbjct: 466 -VVDVMKKSSEEQIAKLQK--LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY 522
Query: 372 LEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQ-ALQK 430
L+ S + Q E+ L + K L E ++ LQ + +++ES+L+ +LQ+
Sbjct: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
Query: 431 LYSQS---------QKEQRNL--------------ALELKYGLLLLKDLELSKQDFKEEM 467
+QS +K + N +L+ + L + L++ KQ ++ EM
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 468 QGIVE----ENKTL------------HELNFSSTRSLKKQQMEISKLKEIKEKLEREFHT 511
+ + E E +TL E+N + L +Q E+ L ++ + H
Sbjct: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 512 STEESNVLQRETHQIKDDIQ-HLNERYQAMLEQLQSL----GLNPNSFAASVRDLQNE-N 565
EE +VL+ +T ++K +++ ++E+ +Q+ S+ ++ +++D N+
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
Query: 566 FMLKETCK--KEHSEKEALREKSKDMNEVLMENACMEFSLL-----GLNDELDGLRGTVK 618
+LKE K KEH E +E ++ A + + +++ +
Sbjct: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 619 EIQQFCQVLQEEKSILADE-------KSTLLSQLQI----ITESMQKILENNTVLEKSLS 667
++QQ L+ E+ +L + K + ++L + + MQ++ + N+ +E+ +
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK 882
Query: 668 DAKIEFEGLRIKSG--DLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLS--------- 716
+E +++ G + E ++L +++N + R ++EI+ +KLS
Sbjct: 883 SLTQVYES-KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
Query: 717 ---------NLEKKVTNLEEKYADVEK-------DKESAVNQVEELFASILVQKENHSNH 760
N EKK+ +++K ++++ D+E+ + + E A L QKE N
Sbjct: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
Query: 761 K--HSSEARLANLENIVRVLQEEQR-----LGKVEFEQELDRVVN-------------AQ 800
K ++A A + + V L+ Q+ L +V +EL+ V++ +
Sbjct: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH-RRELNDVISIWEKKLNQQAEELQE 1060
Query: 801 IEMFILQNCIEEL-ELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRI 859
I LQ +E+ ELK +LL CEK + +K I+ L+ E ++++ L+ +
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEK-----EEMNKEITWLKEEG----VKQDTTLNEL 1111
Query: 860 RKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEEN---QQL 916
++ Q+ N + ++E +++ +E LE L KS +EN Q+
Sbjct: 1112 QE------------QLKQKSAHVNSLAQDE---TKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 917 LVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMR----EQNVILQKDKVELLEENRQL 972
LVE +L ++ + + +L + KT ++EF++++ + N L+ +E + + +L
Sbjct: 1157 LVELKML---AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 973 RI------------------EVVN-GVEKENRSKSTLAALQAEMIELRQ-------TNQV 1006
I E++N K N S ++ Q ++++ T
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 1007 FQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVE 1066
+ + ++ +E+N+L N+S + E EN + + +L E E +
Sbjct: 1274 LEAQLRQLTEEQNTL--NISFQQATHQLEEKENQIKSMKA-DIESLVTEKEALQKEGGNQ 1330
Query: 1067 KRALCEHLGNLSHLNNDLNQEFG---VLRKNFEVKEAE-----------NVYLNESIERM 1112
++A E ++ L +L++ ++++ + K+ E NV L SI
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS 1390
Query: 1113 DKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKE- 1171
+KE R K + E +++L + + +K K + Q+ + S KK+
Sbjct: 1391 EKEAAISSLR-KQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 1172 ----IEHLNEANE-TLQFEMKT------------LLHEVEQHRVREEALNLELLNKENEF 1214
+H N E +Q E+K+ L E++Q R + L E+ E++
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM---EDDK 1506
Query: 1215 KLWENEAAAFYHDLQMSSICLALLE----SKVSELTGVCKILDDESSAKSLEN------- 1263
E + + +L+ + + LE K E+ + ++L + + K +E+
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 1264 EHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNS----LEHISL--------LWTKR 1311
+H +E+ ++ + +E++ V S+K + + LEH++L L
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 1312 NSVVGNGAQKDVVIE-------TCLRKHSHQSARENEIVLIPDGVSDLLTLQTRI--RAV 1362
+ + A K ++ ++K E E S L L T++ R
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 1363 EKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKE--IELVEE---NVFDRNSW 1417
E ++EE + V+ T P S+ +A Y + E + ++ E +V RN
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 1418 RKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMI 1477
K+ ++ + ++ + +S + R + LE E +HE D +MI
Sbjct: 1747 EKEKLLQRVGQE-----KEETVSSHFEMRCQYQERLIKLEHAEAKQHE-------DQSMI 1794
Query: 1478 CH---RSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLA 1534
H ++ + + +EKE G + ++ +++ E DD ++ L+ +K
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL-ENVFDDVQKTLQ------EKEL 1847
Query: 1535 ILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSIN---DQMAKNVEE 1591
++ Q +K+ + K+ + +E E + E++ +A+ Q N + + +N EE
Sbjct: 1848 TCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL-QALQQMDGRNKPTELLEENTEE 1906
Query: 1592 GASS--LDREIPRRGSEQIGKLQFEVQNIQYILLKLAEE 1628
+ S + ++ Q L+F++ + KL +E
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKE 1945
Score = 102 bits (253), Expect = 1e-20
Identities = 242/1236 (19%), Positives = 511/1236 (40%), Gaps = 161/1236 (13%)
Query: 461 QDFKEEMQGIVEENKTLHE--LNFSSTRSLKKQQMEISKLKEIKEKLEREFHTST-EESN 517
Q F +++Q V ++L + S RS K+ + + +E +L+ + T++ + +
Sbjct: 59 QSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPS 118
Query: 518 VLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHS 577
+ E + + LN+ + ++++L+ + + +S+ +L ML+ KK
Sbjct: 119 DMDSEAEDLVGNSDSLNK--EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 578 EKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADE 637
++KS L E M+ QQ + LQEE +E
Sbjct: 177 ILSQSQDKSLRRIAELREELQMD--------------------QQAKKHLQEEFDASLEE 216
Query: 638 KSTLLSQLQIITESMQKILEN---NTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEK 694
K +S LQ +++ L N N + K L + + E + D ++ D
Sbjct: 217 KDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGT 276
Query: 695 NNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQK 754
+ E L +++ E L ++ + + +E+ + +KE+ Q++E + K
Sbjct: 277 SVKTLET--LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 755 ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELE 814
+ H K +L + +N++ L++++ + E ++++ + + E I +L
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEE------IAQLR 388
Query: 815 LKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQ 874
+ + T+ E+L E + S++ E + L + E RK K ++ + ++
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE---EARRKLKAEMDEQIKTIE 445
Query: 875 IDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEG 934
S+ +E I + + L +++ ++K E E L L + +
Sbjct: 446 KTSE--------EERISLQQELSRVKQEVVDVMKKSSE------EQIAKLQKLHEKELAR 491
Query: 935 EKLKLEKKTVEQEFENMREQNVILQKDKVELL------EENRQLRIEVVNGVEKE--NRS 986
++ +L KK +E E + V L+K + E L E+ L +E + +K S
Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551
Query: 987 KSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVS-DLKDAKSSAEDENSVMFH- 1044
++ L LQ E R + K L E + ++++ L+ K+ E +VM
Sbjct: 552 ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611
Query: 1045 DVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFE-VKEAENV 1103
L +L + +TE + + ++ + L QE L K+ E + +A
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQ--QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 669
Query: 1104 YLNE-SIERMDKELLEMDKRLKAAETSNAEFSRH--IEELKMEQEESTKIKENLDRQILE 1160
+NE ++E++D + E++ ++E S +RH EEL + ++++ K+K+ L+ ++ E
Sbjct: 670 EMNEKTLEKLDVKQTELES--LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE 727
Query: 1161 QSENCMNHKKEIEHLNEANE-TLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWEN 1219
Q +H+++++ + + +E ++Q K L ++ Q LELL KE + L E+
Sbjct: 728 QKN---HHQQQVDSIIKEHEVSIQRTEKALKDQINQ---------LELLLKERDKHLKEH 775
Query: 1220 EAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGG 1279
+A + LE+ + G + ++SAK + + +S
Sbjct: 776 QAH------------VENLEADIKRSEGELQ----QASAK----------LDVFQSYQSA 809
Query: 1280 LKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRK-------- 1331
EQ AY ++ L++ LE +L TK+ + V +KDV E K
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV-EAQKKDVCTELDAHKIQVQDLMQ 868
Query: 1332 --HSHQSARENEIVLIPDGVSDLL------TLQTRIRAVEKIMMEELKRRVKQKSLTTES 1383
S E ++ + L QT+ VEK M R ++K + +
Sbjct: 869 QLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILT 928
Query: 1384 TPYSSLEIATY-------PKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNV 1436
S+ E + + K +N++K++E V++ + KK +LL ++ L + +
Sbjct: 929 QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK---KLLDQEAKLKKEL 985
Query: 1437 DDQNSKYLKREHRRTNDHVLELCENNEH---------EPLSAPTVDHAMICHRSDDSGRY 1487
++ + L ++ ++ N +LE+ + N E ++ HR + +
Sbjct: 986 EN-TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 1488 LNYSSELDIEKE--LGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKK 1545
+ +L+ + E + +++L + +E E ++ +L + I + + +K+
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ 1104
Query: 1546 KT-------ETKKKSKQGNDIEYE--TVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSL 1596
T + K+KS N + + +K H+E++E + + + N + + + E L
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE-LKML 1163
Query: 1597 DREIPRRGSEQIGKLQFEVQNIQYILLKLAEENNNK 1632
E R+ SE KL+ + Q LK + E +NK
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQ--SLKSSHEKSNK 1197
>CEP2_HUMAN (Q9BV73) Centrosomal protein 2 (Centrosomal
Nek2-associated protein 1) (C-NAP1) (Centrosome protein
250) (Centrosome associated protein CEP250)
Length = 2442
Score = 152 bits (383), Expect = 1e-35
Identities = 311/1579 (19%), Positives = 649/1579 (40%), Gaps = 191/1579 (12%)
Query: 140 NERSSE----ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKA----QN 191
+ERS E +S G+++ + L ++ AL Q Q+ E+ KM L + +
Sbjct: 261 HERSQELIQLKSQGDLE--KAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILET 318
Query: 192 NARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIAR---LESMLSQKDNI 248
N L + EA + +E L + KD +V+ + + IA+ E+ L +I
Sbjct: 319 NHTELMEH--EASLSRNAQEEKLSLQQVIKDITQVMVEEG-DNIAQGSGHENSLELDSSI 375
Query: 249 EAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVET 308
++ Q+ + + +VL + +Q ++ L ++A +E +L Q ++ E E +
Sbjct: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQD---LRQQLAGCQEAVNLLQQQHDQWEEEGKA 432
Query: 309 LRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKH 368
LR+ L ++ ERD+L+ + ++ E+ + + E L+ E+ ++LE+ E+
Sbjct: 433 LRQRLQKLTGERDTLA-------GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQE 485
Query: 369 RGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHG-------EHSNFIQI 421
L + N LQL+ ++ + + EL E ERLQ ++ G S I +
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITL 545
Query: 422 ESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELN 481
AL++ ++EQ + L + +L S+ K E+ + L LN
Sbjct: 546 REALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605
Query: 482 FSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQ---RETHQIKDDIQHLNERYQ 538
+ ++ +L+E + + + + N LQ E + ++ + N +
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 539 AMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENAC 598
A L++ + G A +RD+Q E KE +K+ SE +E + E L + A
Sbjct: 666 AQLQKAEEAGA---ELQADLRDIQEE----KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Query: 599 MEFSLLG-LNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILE 657
+ +L E + L ++ Q ++ ++ LA++ L S +++ S+ + +
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
Query: 658 NNTVLEKSLSDAKIEFEGL----RIKSGDLEDCCKL-LNDEKNNLQNERSMLISQL---- 708
N+V+E + +++ + + + G++ C KL L+ E++ + ER QL
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR-CLKLELDTERSQAEQERDAAARQLAQAE 837
Query: 709 ----EIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSS 764
+E++ + EK+V L EK+ +KE + +Q +EL ++ E+ K
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKW-----EKERSWHQ-QELAKAL----ESLEREKMEL 887
Query: 765 EARLANLENIVRVLQ---EEQR------LGKVEFEQELDRV------VNAQIEMFILQNC 809
E RL + + +Q EE+R L +++ E E +RV + Q E+
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 810 IEEL-------ELK----NFVLLTECE----KLVEASKFSDKVISELESENLMQLIEEEF 854
+E L +LK +L T+ + +L EA++ ++ L+ E+ L ++
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 855 LLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIK---KEEIPISRILDKIESLESSLVKS-Q 910
L ++ K + V Q DS + E++ +E +RI ++E ++SL S
Sbjct: 1008 LQKQVEDLKSQL-----VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLM 1062
Query: 911 EENQQLLV----------ENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQK 960
E+ Q+LLV E S L +Q+ Q E ++L + + + QE ++E+
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE---VKEKEADFLA 1119
Query: 961 DKVELLEE-------NRQLRIEV----VNGVEKENRSKSTLAALQAEMIELRQTNQVFQE 1009
+ +LLEE +QLR + + + R +ST + L+A E + NQ +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
Query: 1010 EN-----GKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENM 1064
+ S+C + +L SA V L F
Sbjct: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAP--------SVWGLEPDQNGARSLFKRGP 1231
Query: 1065 VEKRALCEHLGNLSH-LNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRL 1123
+ E + + H L+ DL ++ ++ +V L + ++++++ L + +
Sbjct: 1232 LLTALSAEAVASALHKLHQDL----------WKTQQTRDV-LRDQVQKLEERLTDTEAEK 1280
Query: 1124 KAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQ 1183
T + R + + + E+ + + +L+ +++E E + + + Q
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 1184 FEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVS 1243
E + L E + E L ++ E + + A DL+ + L L +V
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVV----EARAQASAAGILEEDLRTARSALKLKNEEVE 1396
Query: 1244 ELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFN---- 1299
+ L ++ K + + ++E ++LL + +E++ + L++
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKA 1456
Query: 1300 SLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSH----QSARENEIVLIPDGVSDLLTL 1355
+LE +SL KRN V ++ +E C H RE ++ + + + +L
Sbjct: 1457 ALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL--- 1513
Query: 1356 QTRIRAVEKIMMEELKRRVKQKSLTTES---------TPYSSLEIATYPKVENRKKEIEL 1406
+ R ++ ++E +++K ES +LE EN K +E
Sbjct: 1514 -EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK-MEC 1571
Query: 1407 VEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVL--ELCENNEH 1464
++ + + R+ ++ L + L+ + ++ + ++ VL EL E ++
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE 1631
Query: 1465 EPLSAPTVDHAMIC--HRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEK-TEDDKRR 1521
++ H + D R EL ++KE + LE ++ + K E+D +
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLER---RDQELMLQKE-RIQVLEDQRTRQTKILEEDLEQ 1687
Query: 1522 ILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSI 1581
I L G++L + +Q+ ++ + K+++G+ + + R E+ E + +
Sbjct: 1688 IKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE 1747
Query: 1582 NDQMAKNVEEGASSLDREI 1600
++ +E+ L R++
Sbjct: 1748 LQELKDQLEQQLQGLHRKV 1766
Score = 129 bits (324), Expect = 7e-29
Identities = 248/1223 (20%), Positives = 500/1223 (40%), Gaps = 160/1223 (13%)
Query: 136 RSKKNERSSEESNGEVQTLREALAKMQSDK-------DALFLQYQESLENLSKMETDLNK 188
R E + + E+Q L+ L++ Q +K ++L + E E ++ +++ L +
Sbjct: 1272 RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR 1331
Query: 189 AQ------NNARGLDDRASE-AEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESM 241
A+ R L A E QVE L+ ++++ +A A +L E + S
Sbjct: 1332 AELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE----EDLRTARSA 1387
Query: 242 LSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIER 301
L K N E ++ ++ + Q + + Q K E + +L +A EE L QI+
Sbjct: 1388 LKLK-NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446
Query: 302 TELE-------VETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNK 354
E + +E L +L + N+E D L ++++ K + + H+ ++ + K
Sbjct: 1447 LEKQREMQKAALELLSLDLKKRNQEVD----LQQEQIQELEKCRSVLEHLPMAVQEREQK 1502
Query: 355 IEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGE 414
+ + E++ EK R ++ LE E Q I S+ ++ + ++ L+ L
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 415 HSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEEN 474
N ++E + +++L + Q+E + +A L L L D +E Q + ++
Sbjct: 1563 EENHHKMECQQKLIKEL--EGQRETQRVA---------LTHLTL---DLEERSQELQAQS 1608
Query: 475 KTLHELNFSST---RSLKKQQMEISKLKEIKEKLEREFHTSTEESN------VLQRETHQ 525
+H+L ST R L+++ E+ +E E+L+R+ T++ +LQ+E Q
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
Query: 526 IKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREK 585
+ +D + + + E L+ + L S R+L + +++E ++ +A R
Sbjct: 1669 VLED--QRTRQTKILEEDLEQIKL---SLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 586 SKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSIL---ADEKSTLL 642
+ M +L + E++ + + E+Q+ L+++ L E S LL
Sbjct: 1724 LEHMKLILRDK----------EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLL 1773
Query: 643 SQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERS 702
SQ + Q+I+ L+++ +++ + L+ + + + + E LQ E+
Sbjct: 1774 SQRE------QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 703 MLISQLEIVEEKL----SNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHS 758
Q E V+EK LE+ L+E++ +++ KE A EEL
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV---------- 1877
Query: 759 NHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIE---ELEL 815
R+ LE ++ L+ E R EQE + + + Q C E E E+
Sbjct: 1878 -----EGRRVQALEEVLGDLRAESR------EQE-------KALLALQQQCAEQAQEHEV 1919
Query: 816 KNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQI 875
+ L + K D+ + L +E+ +EE R + + K LQ
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ- 1978
Query: 876 DSDGGGDNEIKKEEIPISRILD-KIESLESSLVKSQEENQQLLVENSVLLGSLQ----QH 930
G + E+ +SR L+ +L++SL Q ++QL + G +Q ++
Sbjct: 1979 -----GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRY 2033
Query: 931 QSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEEN---------RQLRIEVVNGVE 981
Q + ++L+ ++E + +E+ +L+K + ++EN ++ E + G+
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 982 KENRS-KSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENS 1040
+ R + TLA + E++ELR+T Q N + L + S +++ +
Sbjct: 2094 QSVRELQLTLAQKEQEILELRETQ---QRNNLEALPHSH----KTSPMEEQSLKLDSLEP 2146
Query: 1041 VMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEA 1100
+ ++ L E E + + L L + L + L+ + +++
Sbjct: 2147 RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS 2206
Query: 1101 ENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILE 1160
E L + +E + + LE ++ TS AE E+ E S E + +
Sbjct: 2207 EQQRLQDELE-LTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
Query: 1161 QSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENE 1220
QS ++ +EHL +A L+ + L ++H V+ + LE + +E E
Sbjct: 2266 QS-----WRQRLEHLQQAVARLEIDRSRL----QRHNVQLRS-TLEQVERERRKLKREAM 2315
Query: 1221 AAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGL 1280
AA L++S S ++ G + D L+ E + LL++++
Sbjct: 2316 RAAQAGSLEISK----ATASSPTQQDGRGQKNSDAKCVAELQKE-----VVLLQAQLTLE 2366
Query: 1281 KEQLSAYVPLVSSLKEDFNSLEH 1303
++Q Y+ + + L H
Sbjct: 2367 RKQKQDYITRSAQTSRELAGLHH 2389
Score = 115 bits (288), Expect = 1e-24
Identities = 315/1688 (18%), Positives = 661/1688 (38%), Gaps = 211/1688 (12%)
Query: 47 IEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPN 106
+EEE S R E + R L + E + AL E+ H +L+ A + E
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE---- 677
Query: 107 SAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKD 166
L D + + H+ + E+ + E + E LA+ +K+
Sbjct: 678 -----LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732
Query: 167 ALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEV 226
AL + + +E L + + + L ++ E+L+ SL + + EV
Sbjct: 733 AL-------VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785
Query: 227 LYNQC---LETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLEN 283
Q ++T+ + + ++ + L E ++ ++D Q Q + E
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ-----EG 840
Query: 284 KIALAEE---NSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENE 340
K AL ++ + + +N E+ E E ++ LA+ E LE+ KME E
Sbjct: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES-----------LER-EKMELE 888
Query: 341 ILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAE----NLVQRIASKDHE 396
+ ++ E + ++E E R E + +QLE E +L++ + E
Sbjct: 889 MRLKEQQTEMEAIQAQREEE--------RTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 397 LLEKHTEIERL------QTLMHGEHSNFIQIESALQALQKLYSQSQKEQRN--LALELKY 448
L + ++ERL Q L E + +Q + LQ Q+ ++ ++ R+ AL+ +
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQ--LQEAQRELKEAARQHRDDLAALQEES 998
Query: 449 GLLLLKDLELSKQ--DFKEEM------QGIVEE---------------NKTLHELNFSST 485
LL ++L KQ D K ++ Q +VE+ K L S T
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
Query: 486 RSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQ------- 538
SL +++ + L+E ++E ++ Q E ++ ++ L + +
Sbjct: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFL 1118
Query: 539 ----AMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
+LE+L++ + AS+ + + L+ + S+ EAL + + N+
Sbjct: 1119 AQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA 1178
Query: 595 ENACMEF----------------SLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEK 638
+ L G D + G + + + + A
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
Query: 639 STLLSQLQIITESMQKILENNTV-------LEKSLSDAKIEFEGLRIKSGDLEDCCKLLN 691
+ S L + + + K + V LE+ L+D + E + + DL+
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298
Query: 692 DEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKD-------KESAVNQVE 744
+EK+ + +++ L S+L + E +++L+ ++ E + + + + KE+ QVE
Sbjct: 1299 EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
Query: 745 ELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMF 804
L A++ V+ ++ E L + +++ EE VE E+E + + Q E+
Sbjct: 1359 HLQAAV-VEARAQASAAGILEEDLRTARSALKLKNEE-----VESERERAQALQEQGELK 1412
Query: 805 ILQNCIEELELKNFVLLT----ECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIR 860
+ Q + +N LLT E E+ VE + I ELE + MQ E L ++
Sbjct: 1413 VAQG---KALQENLALLTQTLAEREEEVETLRGQ---IQELEKQREMQKAALELLSLDLK 1466
Query: 861 KFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVEN 920
K ++D E++K + + ++ E L +E+ ++L +
Sbjct: 1467 KRNQ---------EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Query: 921 SVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGV 980
L+ E EK ++ + +++++Q V L+ +EL E + ++ +
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577
Query: 981 EKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENS 1040
E E + ++ AL ++L + +Q Q ++ ++ D ++ +L++ + +
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 1041 VMFHDVLALSNLNLVYEIFFTENMVEKRAL----CEHLGNLSHLNNDLNQEFGVLRKNFE 1096
+ +L E E M++K + + L DL Q LR+
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 1097 VKEAENVYLNESIE------RMDKELLEMDKRLKAAETSNAEFSR-HIEELKMEQEESTK 1149
+ + E E + + LE K + + E + HI EL+ +++ +
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 1150 IKENLDRQILEQSENCMNHKKEI----EHLNEANE-------TLQFEMKTLLHEVEQHRV 1198
+ L R++ E S ++EI + L EA E +LQ ++ + Q
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 1199 REEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSA 1258
EAL E + + + + +A A L+ + + L ++ + + L++E +
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
Query: 1259 KSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLE----HISLLWTKRNSV 1314
+ + + E++ L +E +EQ A + L E E + W + +V
Sbjct: 1878 EGRRVQALEEVLGDLRAE---SREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 1315 VGNGAQKDVVIETCLRKHSHQSARENEIVLI-PDGVSDLL-TLQTRIRAVEKIMME--EL 1370
+ ++D +E LR S S + E + + + L ++ E+ ++E EL
Sbjct: 1935 L---KERDQELE-ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
Query: 1371 KRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDI 1430
R ++ + T +++ + + + R +E E+ ++++ + ++ + L +D
Sbjct: 1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ-ALAQRDE 2049
Query: 1431 PLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNY 1490
L R+ ++ K +R +++++ +N E R ++ R L+
Sbjct: 2050 EL-RHQQEREQLLEKSLAQRVQENMIQEKQNLGQE--------------REEEEIRGLHQ 2094
Query: 1491 SSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETK 1550
S +EL + + + + E E +R LE L + + + +L+ + +
Sbjct: 2095 S-----VRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ 2149
Query: 1551 KKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMA--KNVEEGASSLDREIPRRGSEQI 1608
++ ++ +T R IE E+A +S+ A +++E A L + R SEQ
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQ- 2208
Query: 1609 GKLQFEVQ 1616
+LQ E++
Sbjct: 2209 QRLQDELE 2216
Score = 101 bits (252), Expect = 2e-20
Identities = 186/980 (18%), Positives = 417/980 (41%), Gaps = 137/980 (13%)
Query: 134 THRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMET---DLNKAQ 190
T + E E G++Q L + ++ + L L ++ + + + +L K +
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 191 NNARGLDDRASEAEIQVEILKESLMQLKADKDAGE-VLYNQCLETIARLESMLSQKDNI- 248
+ L E E ++ + +E + +L+ D++ VL +Q LE + + + SQ+ +
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ 1546
Query: 249 ----------------EAKNLKQELTRVVV-----QKDT-------VLLQYKQCLEKIPM 280
E + K E + ++ Q++T + L ++ +++
Sbjct: 1547 DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 281 LENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENE 340
++I E +S +L +++ + EV++ R+ + E+ +++ H + + + + E
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE-------HLTQDLERRDQE 1659
Query: 341 ILHVQENAEQLKNK-------IEKEAEKLEISEKHRGM-LEKSNQNLQLEAE-----NLV 387
++ +E + L+++ +E++ E++++S + RG L Q +Q AE +
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 388 QRIASKDHELL--EKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQ-----SQKEQR 440
QR + + +L+ +K E+E Q +H Q+E LQ L + + SQ+EQ
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779
Query: 441 NLALELKYGLLL----LKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEIS 496
+ L+ + LK+ L Q E + + + ++ L L ++ +++
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQ-LDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 497 KLKEIKEKLEREFHTSTEESNVLQ---RETHQIKDDIQHLNERYQAMLEQLQSLGLNPNS 553
K ++ LE+ T E LQ + ++++++ R QA+ E L L
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL------ 1892
Query: 554 FAASVRDLQNENFMLKETCKKEHSEKE----ALREKSKDMNEVLMENACMEFSLLGLNDE 609
A R+ + L++ C ++ E E AL++ VL E + E
Sbjct: 1893 -RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER----------DQE 1941
Query: 610 LDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDA 669
L+ LR + + + + L + + LQ + + + E + LE S +
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 670 KIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKY 729
+ + + S LE+ ++ ++ +Q++ ++ +++ L+ ++++ + +E+
Sbjct: 2002 QASLDACQAHSRQLEEALRI---QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE 2058
Query: 730 ADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEAR------------LANLENIVRV 777
+EK S +V+E +++ +K+N + E R LA E +
Sbjct: 2059 QLLEK---SLAQRVQE---NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Query: 778 LQEEQRLGKVE---FEQELDRVVNAQIEMFILQNCIE-ELE-LKNFVLLTECEKLVEASK 832
L+E Q+ +E + + +++ L+ ++ ELE L+ + TE ++ K
Sbjct: 2113 LRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172
Query: 833 FSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPI 892
D +S +++ + ++E + + VL+ DS+ + ++E+ +
Sbjct: 2173 AQDLALSLAQTKASVSSLQEVAMFLQ-----------ASVLERDSE----QQRLQDELEL 2217
Query: 893 SRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMR 952
+R + E L S S E E V LG + ++E +EK++ Q E+++
Sbjct: 2218 TRRALEKERLHSPGATSTAELGSR-GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQ 2276
Query: 953 EQNVILQKDKVELLEENRQLRIEVVNGVEKENR--SKSTLAALQAEMIEL-RQTNQVFQE 1009
+ L+ D+ L N QLR + VE+E R + + A QA +E+ + T +
Sbjct: 2277 QAVARLEIDRSRLQRHNVQLR-STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQ 2335
Query: 1010 ENGKMLDEKNSLCRNVSDLK 1029
++G+ +KNS + V++L+
Sbjct: 2336 QDGR--GQKNSDAKCVAELQ 2353
Score = 95.1 bits (235), Expect = 1e-18
Identities = 211/1075 (19%), Positives = 423/1075 (38%), Gaps = 120/1075 (11%)
Query: 252 NLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRK 311
N+K + ++V+++ + LQ + M EN+ A + R L + E + + +RK
Sbjct: 10 NMKPQSLQLVLEEQVLALQQQ-------MAENQAA----SWRKLKNSQEAQQRQATLVRK 58
Query: 312 NLAEMNEERDSLSVLYHHCLEKISKMENEILHVQE-NAEQLKNKIEKEAEKLE----ISE 366
A++ + R L + +V+E N ++L ++E+E ++ E ++
Sbjct: 59 LQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNT 118
Query: 367 KHRGMLEKS---NQNLQLEAENLVQRIASKDHELLEKHT----EIERLQTLMHGEHSNFI 419
+ R +EK+ N+ L+ + E L + EL+ K + E E + + GEH +
Sbjct: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Query: 420 QIESALQALQKLYSQSQKEQRNLALELKY------GLLLLKDLELSKQDFKEEMQGIVEE 473
+ + ++ + + + +ELK G LL L L+ E G
Sbjct: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNG---- 234
Query: 474 NKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHL 533
S R ++ ++ L ++LE+E H ++E L+ + K ++Q
Sbjct: 235 ----------SGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDR 284
Query: 534 NERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVL 593
A+L Q Q + ++R E + ET E E EA ++ ++
Sbjct: 285 VTELSALLTQSQKQNEDYEKMIKALR----ETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 594 MENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQ 653
++ + + + V+E Q E S+ D S++ SQ +
Sbjct: 341 LQQVIKDITQV-----------MVEEGDNIAQGSGHENSLELD--SSIFSQFDY--QDAD 385
Query: 654 KILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEE 713
K L T++ L+ + + LR + ++ LL + + + E L +L+ +
Sbjct: 386 KAL---TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 714 KLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLEN 773
+ L + +L+ + + K++E EEL + V ++ EA N
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ---------EAWRLRRVN 493
Query: 774 IVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKF 833
+ LQ + G+ E +QE + + E LQ + LE K L+E L EA +
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERER--LQEMLMGLEAKQSESLSELITLREALE- 550
Query: 834 SDKVISELESENLMQ-LIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPI 892
S LE E L Q E L R + ++ L+ + +K +
Sbjct: 551 ----SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 893 SRILDKIESLESSLVKSQEENQQL---LVENSVLLGSLQQHQSEGEKLK---LEKKT-VE 945
+ LDK+ L L++ +EENQ + + +LQ +E EK + EK T +E
Sbjct: 607 ALALDKV-GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 946 QEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQ 1005
+ + E LQ D ++ EE +++ ++ E+R + A Q E +L Q +
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKL-----SESRHQQEAATTQLE--QLHQEAK 718
Query: 1006 VFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMV 1065
+E + + EK +L R + L+ + E + + + LS+ + E E
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
Query: 1066 EKRALCEHLGNLSHLNNDLNQEFGVLRKNFEV----KEAENVYLNESIERMDKELLEMDK 1121
+ + G L + Q V++ + E + + ++L + ++
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 1122 RLKAA-ETSNAEFSRHIEELK--------MEQEESTKIKENLDRQILEQSENCMNHKKEI 1172
K A E A + + +L+ Q+E K E+L+R+ +E + E+
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898
Query: 1173 EHLNEANETLQFEMKTLLHEVEQHRVREEALNLE-LLNKENEFKLWENEAAAFYHDLQMS 1231
E + E + + ++ L +++ +E LE LL + E + D+++
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
Query: 1232 SICLALLESKVSELTGV--CKILDDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
+ K E TG+ ++ + + K +H ++ +L E L++++
Sbjct: 959 KL-------KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Score = 81.3 bits (199), Expect = 2e-14
Identities = 201/1018 (19%), Positives = 397/1018 (38%), Gaps = 121/1018 (11%)
Query: 631 KSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLL 690
K L E LLS + + + LE + ++ L + K E L SG L CC L
Sbjct: 167 KGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRL---SGSLLTCCLRL 223
Query: 691 -----NDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEK----DKESAVN 741
+ E N +QL ++ K LEK+ ++ ++ +K +
Sbjct: 224 TVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQD 283
Query: 742 QVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQI 801
+V EL A + ++ + +++ +A L V +L E +E E L R NAQ
Sbjct: 284 RVTELSALLTQSQKQNEDYEKMIKA----LRETVEIL-ETNHTELMEHEASLSR--NAQE 336
Query: 802 EMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRK 861
E LQ I+++ V++ E + + + S + + EL+S Q +
Sbjct: 337 EKLSLQQVIKDITQ---VMVEEGDNIAQGSGHENSL--ELDSSIFSQFDYQ--------- 382
Query: 862 FKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENS 921
D K +++ + + + + + ++ + ++ Q+++ Q E
Sbjct: 383 ---DADKALTLVR--------SVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431
Query: 922 VLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVE 981
L LQ+ E + L + ++ E +++ ++ +LQK + EL ++ +EV+
Sbjct: 432 ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ-----LEVLEQEA 486
Query: 982 KENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSV 1041
R + LQ + + ++ Q QEE + E+ L + L +AK S +
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQEMLMGL-EAKQSESLSELI 543
Query: 1042 MFHDVLALSNLNLVYEIFFTENMVEKRALC---EHLGNLSHLNNDLNQEFGVLR----KN 1094
+ L S+L E+ E AL + + LS N L E LR K
Sbjct: 544 TLREALESSHLE--GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601
Query: 1095 FEVKEA---ENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIK 1151
+ EA + V LN+ + ++++E + R++AAE + + E + +E +
Sbjct: 602 SALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN 661
Query: 1152 ENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKE 1211
+L+ Q+ + E + ++ + E E +Q ++ H+ E + E L+ E +E
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 1212 NEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREI-- 1269
E A + + L +E +L + L SSAK L + E
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDL---AEQLQGLSSAKELLESSLFEAQQ 778
Query: 1270 -ISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLE-----HISLLWTKRNSVVGNGAQKDV 1323
S++E G L+ Q+ ++ + L+ S +R++ AQ +
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 1324 VIETCLRKHSHQSARENEIVLIPDGVSDLLT--LQTRIRAVEKIMMEELKRRVKQKSLTT 1381
+T L + ++A E E+ + + + Q +A+E + E+++ ++ K T
Sbjct: 839 EGKTALEQ--QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 1382 ESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDD--- 1438
E + R++E E + +K ++ LL + + + D
Sbjct: 897 EMEAIQA----------QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946
Query: 1439 ------QNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSS 1492
Q+ K K + + T + + + E + A HR D + SS
Sbjct: 947 QLERLRQDMKVQKLKEQETTGILQTQLQEAQRE------LKEAARQHRDDLAALQEESSS 1000
Query: 1493 ELDIEKELGVDKLELSKSVKE-----KTEDDKRRILERLSSDGQKLAILKMALQDLKKKT 1547
L DK++L K V++ +DD +R++E+ + Q+ ++K+
Sbjct: 1001 LLQ-------DKMDLQKQVEDLKSQLVAQDDSQRLVEQ---EVQEKLRETQEYNRIQKEL 1050
Query: 1548 ETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSI--NDQMAKNVEEGASSLDREIPRR 1603
E +K S + +E E ++E + Q++S D E+ S E+ R+
Sbjct: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ 1108
Score = 73.2 bits (178), Expect = 6e-12
Identities = 166/850 (19%), Positives = 325/850 (37%), Gaps = 115/850 (13%)
Query: 6 ESESRRLYSWWWDSHNSPKNSKWLLENLTDIDTKVKSMIKLIEE-------EADSFARRA 58
E S+ L + H+ +S L L + D +VKS + IEE RR
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657
Query: 59 EMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPC 118
+ ++ + L ++ R + L E + LR + +
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL------------------ 1699
Query: 119 GSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREALAKMQ---SDKDALFLQYQES 175
T R ER +EE G + R +L M+ DK+ QE
Sbjct: 1700 --------------TTQRQLMQER-AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 176 LENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLM----QLKADKDAGEVLYNQC 231
+ L +++ L + +GL + E + + ++ ++ QL+ ++ GE+
Sbjct: 1745 IHELQELKDQL---EQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL 1801
Query: 232 LETIARLESMLSQKDNIEAKNLKQEL-------TRVVVQKDTVLLQYKQCLEKIPMLENK 284
+ + L+Q+D E + L+QE RV + D + +Q + +
Sbjct: 1802 QSQLDEAQRALAQRDQ-ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE 1860
Query: 285 IALAEENSRMLNDQIERTELEVETLRKNL----AEMNEERDSLSVLYHHCLEKISKMENE 340
+ +E +R L +++ V+ L + L AE E+ +L L C E+ + E E
Sbjct: 1861 LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920
Query: 341 ILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEK 400
+Q++ Q + +++ ++LE + + AE L + + L K
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 401 HTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSK 460
+ L ++ ++++L A Q+ Q AL ++ G + +DL +
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDA-----CQAHSRQLEEALRIQEGEIQDQDLRY-Q 2034
Query: 461 QDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQ 520
+D ++ Q + + ++ L + ++Q +E S + ++E + +E +E +
Sbjct: 2035 EDVQQLQQALAQRDEELRH------QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088
Query: 521 -RETHQIKDDIQ-HLNERYQAMLE-----QLQSLGLNPNSFAASVRD------------L 561
R HQ ++Q L ++ Q +LE Q +L P+S S + L
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL 2148
Query: 562 QNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQ 621
Q E L+ ++ + + REK++D+ + A + S+ L + L+ +V E
Sbjct: 2149 QRELERLQAALRQTEAREIEWREKAQDL---ALSLAQTKASVSSLQEVAMFLQASVLERD 2205
Query: 622 QFCQVLQEEKSIL--ADEKSTLLSQLQIITESMQKILENNTVL------EKSLSDAKIEF 673
Q LQ+E + A EK L S T + E L E S +E
Sbjct: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
Query: 674 EGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVE 733
+ R + L+ L +++ LQ L S LE VE + L+++ + +E
Sbjct: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQA-GSLE 2324
Query: 734 KDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQEL 793
K +A + + ++ K+S +A L+ V +LQ + L + + + +
Sbjct: 2325 ISKATASSPTQ----------QDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYI 2374
Query: 794 DRVVNAQIEM 803
R E+
Sbjct: 2375 TRSAQTSREL 2384
>MYHB_MOUSE (O08638) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 150 bits (379), Expect = 3e-35
Identities = 230/1148 (20%), Positives = 469/1148 (40%), Gaps = 125/1148 (10%)
Query: 129 TSARPTHRSKKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNK 188
T +P + + E + E+Q + E K +++ L ++ + E + ++ L
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEEEMQKITERQQKAETELKELEQKHTQLAEEKTLLQEQLQA 898
Query: 189 -----AQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLS 243
A++ + A + E++ EIL E +L+ ++D + L + + ++ +
Sbjct: 899 ETELYAESEEMRVRLAAKKQELE-EILHEMEARLEEEEDRRQQLQAERKKMAQQMLDLEE 957
Query: 244 QKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTE 303
Q + EA K +L +V + KI LE+ I + ++ + L+ + + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEA------------KIKKLEDDILVMDDQNSKLSKERKLLE 1005
Query: 304 LEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENA---EQLKNKIEKEAE 360
V L NLAE E+ +L+ L IS++E + +++ E+LK K+E +A
Sbjct: 1006 ERVSDLTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 361 KL--EISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNF 418
+I++ + E Q L + E L +A D E+ +K+ +++++ L +
Sbjct: 1066 DFHEQIADLQAQIAELKMQ-LAKKEEELQAALARLDEEIAQKNNALKKIREL----EGHI 1120
Query: 419 IQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD----------LELSKQDFKEEMQ 468
++ L + + ++++K++R+L EL+ L+D L ++ ++
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 469 GIVEENKTLHELNFSSTRSLKKQQME-----ISKLKEIKEKLEREFHTSTEESNVLQRET 523
++E HE R Q +E + + K K L++ T +E+ L E
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGEL 1240
Query: 524 H---QIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRD----LQNE----NFMLKET- 571
Q K +++H ++ + L+ LQS + A + D LQNE ML E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAE 1300
Query: 572 --CKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQE 629
K + +L + +D E+L E + L ++ +L L +Q E
Sbjct: 1301 GKAIKLAKDVASLGSQLQDTQELLQEETRQK---LNVSTKLRQLEDERNSLQDQLDEEME 1357
Query: 630 EKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKL 689
K L STL QL + +Q V+E+ + E EGL + +
Sbjct: 1358 AKQNLERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDK 1417
Query: 690 LNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFAS 749
L KN LQ E L+ L+ + +SNLEKK ++ A+ EK+ + +A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAE-EKN-------ISSKYAD 1469
Query: 750 ILVQKENHSNHKHSSEARLAN-LENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQN 808
+ E + K + LA LE + +E +R K+ + E++ +V+++ ++
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM-LKAEMEDLVSSKDDV---GK 1525
Query: 809 CIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHK 868
+ ELE L T+ E++ + ESE+ +Q E+ L + ++++
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLE---------ESEDDVQATEDAKL-----RLEVNMQA 1571
Query: 869 VCGVLQIDSDGGGD-NEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSL 927
+ G + D + NE K+ ++ ++ E+ L +++ L G L
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQ-----RQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 928 QQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSK 987
+ + + + ++ ++ ++ Q KD L++ R R E+ KEN K
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELDDARASRDEIF-ATSKENEKK 1681
Query: 988 STLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVL 1047
+ +L+A++++L++ + + EK L ++ +++ +DE + +
Sbjct: 1682 AK--SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDEKRRLEARIA 1739
Query: 1048 ALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNE 1107
L E E A+ + + + L+ E R + E+ +
Sbjct: 1740 QL-------EEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESAR----Q 1788
Query: 1108 SIERMDKEL------------LEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLD 1155
+ER +KEL ++ + A E A+ +E+ E++ +TK + D
Sbjct: 1789 QLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 1156 RQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNL--ELLNKENE 1213
+++ E + +K E E E ++K L ++E+ + +N L +E +
Sbjct: 1849 KKLKEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEESQCINANRRKLQRELD 1908
Query: 1214 FKLWENEA 1221
NEA
Sbjct: 1909 EATESNEA 1916
Score = 130 bits (328), Expect = 2e-29
Identities = 205/1080 (18%), Positives = 444/1080 (40%), Gaps = 79/1080 (7%)
Query: 275 LEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKI 334
L ++ E ++ EE + + ++ ++ E E++ L + ++ EE+ L E
Sbjct: 844 LLQVTRQEEEMQAKEEEMQKITERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETELY 903
Query: 335 SKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKD 394
++ E + + ++L+ + + +LE E R Q LQ E + + Q++ +
Sbjct: 904 AESEEMRVRLAAKKQELEEILHEMEARLEEEEDRR-------QQLQAERKKMAQQMLDLE 956
Query: 395 HELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLK 454
+L E+ ++LQ + ++E + + S+ KE++ L +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDDQNSKLSKERKLLEERVS------- 1009
Query: 455 DLELSKQDFKEEMQGIVEENKTLHELNFSSTR-SLKKQQMEISKLKEIKEKLEREFHTST 513
DL + + +E+ + + + K+ HE S LKK++ +L+++K KLE +
Sbjct: 1010 DLTTNLAEEEEKAKNLTKL-KSKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 514 EESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCK 573
E+ LQ + ++K + E QA L +L N+ +R+L+ L+E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDEEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 574 KEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSI 633
E + + ++ +D+ E L E L D LD + + Q + K
Sbjct: 1129 SERAARNKAEKQKRDLGEEL------EALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 634 LADEKSTLLSQLQII----TESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKL 689
L +E + +Q+Q + T++++++ E +++ ++ + L ++ DL ++
Sbjct: 1183 LDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRV 1242
Query: 690 LNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL--- 746
L K +++++ L QL+ ++ K S+ E+ L +K ++ + ES + E
Sbjct: 1243 LGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 747 -------FASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNA 799
AS+ Q ++ + N+ +R L++E+ + + ++E++ N
Sbjct: 1303 AIKLAKDVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNL 1362
Query: 800 QIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLH-R 858
+ + L + + + K + E + E K K E E L Q EE+ + +
Sbjct: 1363 ERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQK-----EMEGLSQQYEEKAAAYDK 1417
Query: 859 IRKFKMDIHKVCGVLQIDSDGGGD--NEIKKEEIPISRILDKIESLESSLV----KSQEE 912
+ K K + + L +D D + ++K++ ++L + +++ S +++ E
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 913 NQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQL 972
++ + L +L++ E+L+ K ++ E E++ + K+ EL + R L
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Query: 973 RIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQ---EENGKMLDEKNSLCRN--VSD 1027
++ + S+ + A + + L Q + E + + DE+N R
Sbjct: 1538 ETQMEEMKTQLEESEDDVQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 1028 LKDAKSSAEDENSVMFHDVLALSNLN---LVYEIFFTENMVEKRALCEHLGNLSHLNNDL 1084
L + ++ EDE A L E+ + + + L L D
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 1085 NQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQ 1144
+E R + + A + + + ++ +L+++ + L AAE + + EEL E
Sbjct: 1658 QRELDDARASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 1145 EESTK-------IKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHR 1197
S K L+ +I + E + +E +++ + + L +E+ R
Sbjct: 1718 ASSLSGRNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATER 1777
Query: 1198 VREE-----ALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVC--K 1250
+ LE NKE KL E E A ++ S +A LE+K+++L +
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLQEVEGAV---KAKLKS-TVAALEAKIAQLEEQVEQE 1833
Query: 1251 ILDDESSAKSL--ENEHMREIISLLESE---IGGLKEQLSAYVPLVSSLKEDFNSLEHIS 1305
+ +++ KSL +++ ++E++ +E E KEQ V LK E S
Sbjct: 1834 AREKQAATKSLKQKDKKLKEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEES 1893
Score = 112 bits (279), Expect = 1e-23
Identities = 222/1146 (19%), Positives = 456/1146 (39%), Gaps = 188/1146 (16%)
Query: 535 ERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
E QA E++Q + +++L+ ++ L E EK L+E+ + E+
Sbjct: 852 EEMQAKEEEMQKITERQQKAETELKELEQKHTQLAE-------EKTLLQEQLQAETELYA 904
Query: 595 ENACMEFSLLGLNDELDGL----RGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
E+ M L EL+ + ++E + Q LQ E+ +A + L QL+
Sbjct: 905 ESEEMRVRLAAKKQELEEILHEMEARLEEEEDRRQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSML------ 704
+ QK+ LEK ++AKI+ LED +++D+ + L ER +L
Sbjct: 965 ARQKLQ-----LEKVTAEAKIK---------KLEDDILVMDDQNSKLSKERKLLEERVSD 1010
Query: 705 -ISQLEIVEEKLSNLEKKVTNLEEKYADVE---KDKESAVNQVEELFASILVQKENHSNH 760
+ L EEK NL K + E +++E K +E + ++E+L + +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 761 KHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVL 820
+A++A L+ + +EE + ++E+ + NA ++ L+ I +L+ L
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDEEIAQKNNALKKIRELEGHISDLQED---L 1127
Query: 821 LTECEKLVEASKFSDKVISELES-----ENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQI 875
+E +A K + ELE+ E+ + + L R+ ++ + K +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 876 DSDGGGDNEIKKEEIP-ISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEG 934
S E++++ + + +++E + + + Q L EN+ L G L+
Sbjct: 1188 RSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAK 1247
Query: 935 EKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV--VNGVEKENRSKSTLAA 992
++++ +KK +E + ++++ + ++ + EL ++ +L+ EV V G+ E K+ A
Sbjct: 1248 QEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 993 LQAEMI--ELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALS 1050
+ +L+ T ++ QEE + L+ L L+D ++S +D+
Sbjct: 1308 KDVASLGSQLQDTQELLQEETRQKLNVSTKL----RQLEDERNSLQDQ------------ 1351
Query: 1051 NLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIE 1110
E M K+ L H+ L+ +D ++ EV E L + +E
Sbjct: 1352 ---------LDEEMEAKQNLERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQKEME 1402
Query: 1111 RMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKK 1170
+ ++ E E + + +++L ++ + ++ NL+++
Sbjct: 1403 GLSQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK------------- 1449
Query: 1171 EIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQM 1230
+ + L E K + + R R EA E K EA +L+
Sbjct: 1450 -----QKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504
Query: 1231 SSICL-ALLESKVSELTGVCKILDD-ESSAKSLENEHMREIISLLESEIGGLKEQLSAYV 1288
++ L A +E VS V K + + E S ++LE + M E+ + LE
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-MEEMKTQLEES------------ 1551
Query: 1289 PLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDG 1348
++D + E L + ++D+ R ++ R
Sbjct: 1552 ------EDDVQATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQ-------- 1593
Query: 1349 VSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVE 1408
LQ ++ E + +E K+R +L A K+E K++EL
Sbjct: 1594 ------LQRQLHEYETELEDERKQR--------------ALAAAAKKKLEGDLKDLELQA 1633
Query: 1409 ENVFD--RNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEP 1466
++ + ++ K++ MKD R +DD R + D + + NE +
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDF--QRELDDA---------RASRDEIFATSKENEKKA 1682
Query: 1467 LSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERL 1526
S A + +D + D+EKE ++L S S + +D+KRR+ R+
Sbjct: 1683 KSL----EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDEKRRLEARI 1738
Query: 1527 SSDGQKL------------AILKMALQ--DLKKKTETKKKSKQGNDIEYETVKRH----- 1567
+ ++L + K LQ L + T++ + Q N+ + ++R
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 1568 --IEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQ---IGKLQFEVQNIQYIL 1622
++EVE AV ++ +E + L+ ++ + E+ L+ + + ++ +L
Sbjct: 1799 SKLQEVEGAVKAKLK---STVAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEVL 1855
Query: 1623 LKLAEE 1628
L++ +E
Sbjct: 1856 LQVEDE 1861
Score = 101 bits (251), Expect = 2e-20
Identities = 199/995 (20%), Positives = 422/995 (42%), Gaps = 134/995 (13%)
Query: 29 LLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDH 88
L NL + + K K++ KL + + +S E+ KK + + +E+ R A +
Sbjct: 1011 LTTNLAEEEEKAKNLTKL-KSKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 89 AMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNE--RSSEE 146
+ +L+ + + ++ + ++KN + E
Sbjct: 1070 QIADLQAQIAELKMQLAKKE--------------EELQAALARLDEEIAQKNNALKKIRE 1115
Query: 147 SNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQ 206
G + L+E L ++ ++ Q ++ E L ++T+L ++ + ++ E +
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 207 VEILKESLMQLKADKDAG-EVLYNQCLETIARLESMLSQ-----------KDNIEAKN-- 252
V +LK++L + +A + + + + + L L Q K +E +N
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENAD 1235
Query: 253 LKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVET---- 308
L EL + K V + K+ ++ L++K + E L+D++ + + EVE+
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGM 1295
Query: 309 ----------LRKNLAEMNEE-RDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEK 357
L K++A + + +D+ +L +K++ + ++ +++ L++++++
Sbjct: 1296 LNEAEGKAIKLAKDVASLGSQLQDTQELLQEETRQKLN-VSTKLRQLEDERNSLQDQLDE 1354
Query: 358 EAEKLEISEKHRGMLEKSNQNLQL-EAENLVQRIASKDHELLEKHTEIERLQTLMHGEHS 416
E E + E+H S N+QL +++ +Q AS E++E+ +RLQ M G
Sbjct: 1355 EMEAKQNLERH-----VSTLNIQLSDSKKKLQDFAS-TIEVMEEGK--KRLQKEMEGLSQ 1406
Query: 417 NFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKT 476
+ + +A L+K ++ Q+E +L ++L L+ +LE ++ F + ++ E K
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQ----LLAEEKN 1462
Query: 477 LHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQR---ETHQIKDDIQHL 533
+ SK + +++ E E ++ L R E + K++++
Sbjct: 1463 IS-----------------SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 534 NERYQAMLEQLQS----LGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDM 589
N+ +A +E L S +G N + S R L+ + +K ++ + +A E +K
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEESEDDVQA-TEDAKLR 1564
Query: 590 NEVLMENACMEFSL-LGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQII 648
EV M+ +F L DE + ++ +Q + L E ++ L DE+ + + +
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDER-----KQRAL 1614
Query: 649 TESMQKILENNTVLEKSLSDAKIEFEGLRIKS-GDLEDCCKLLNDEKNNLQNERSMLISQ 707
+ +K LE + + +D+ I+ IK L+ K E ++ + R + +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELDDARASRDEIFAT 1674
Query: 708 LEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL---FASILVQKENHSNHKHSS 764
+ E+K +LE + L+E A E+ ++ A + EEL AS L + + K
Sbjct: 1675 SKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDEKRRL 1734
Query: 765 EARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCI-------------- 810
EAR+A LE L+EEQ E DRV A ++ L N +
Sbjct: 1735 EARIAQLE---EELEEEQG----NMEAMSDRVRKATLQAEQLSNELATERSTAQKNESAR 1787
Query: 811 EELELKNFVL---LTECEKLVEASKFS-----DKVISELESENLMQLIEEEFLLHRIRKF 862
++LE +N L L E E V+A S + I++LE + + E++ +++
Sbjct: 1788 QQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 863 KMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSV 922
+ +V +LQ++ + + K++ + K++ L+ L +++EE+Q +
Sbjct: 1848 DKKLKEV--LLQVEDERKMAEQYKEQ---AEKGNTKVKQLKRQLEEAEEESQCINANRRK 1902
Query: 923 LLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVI 957
L L + E + E ++ + E + +
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRRGNEASFV 1937
Score = 87.8 bits (216), Expect = 2e-16
Identities = 113/525 (21%), Positives = 228/525 (42%), Gaps = 43/525 (8%)
Query: 25 NSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAE 84
N + L+ NL + K K +L+ EE + ++ A+ + E + + RAL E
Sbjct: 1438 NQRQLVSNL---EKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 85 RYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS 144
+ A EL +K + + +++ G + E A T + ++ +
Sbjct: 1495 ALE-AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALET-QMEEMKTQL 1548
Query: 145 EESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAE 204
EES +VQ +A +++ + AL Q++ L+ ++ E + K + R L + E E
Sbjct: 1549 EESEDDVQATEDAKLRLEVNMQALKGQFERDLQ--ARDEQNEEKRRQLQRQLHEY--ETE 1604
Query: 205 IQVEILKESLMQLKADKDAGEV--LYNQCLETIARLESMLSQKDNIEA--KNLKQELTRV 260
++ E + +L K G++ L Q I E + Q ++A K+ ++EL
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELDDA 1664
Query: 261 VVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEER 320
+D + K+ +K LE + +E+ ++ +LE E L + LA R
Sbjct: 1665 RASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 321 DSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEK---EAEKL--EISEKHRGMLEKS 375
++L +I+++E E+ Q N E + +++ K +AE+L E++ + +
Sbjct: 1725 NTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNE 1784
Query: 376 NQNLQLEAENLVQRIASKDHELLEKHTEIE-----RLQTLMHGEHSNFIQIESALQALQK 430
+ QLE +N EL K E+E +L++ + + Q+E ++ +
Sbjct: 1785 SARQQLERQN---------KELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAR 1835
Query: 431 LYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKK 490
+ K + +LK LL ++D + +KE+ + + N + +L R L++
Sbjct: 1836 EKQAATKSLKQKDKKLKEVLLQVEDERKMAEQYKEQAE---KGNTKVKQLK----RQLEE 1888
Query: 491 QQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNE 535
+ E + + KL+RE +TE + + RE + +K ++ NE
Sbjct: 1889 AEEESQCINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 81.6 bits (200), Expect = 2e-14
Identities = 168/864 (19%), Positives = 344/864 (39%), Gaps = 129/864 (14%)
Query: 811 EELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVC 870
EE++ K E +K+ E + ++ + ELE ++ QL EE+ LL + + +++
Sbjct: 852 EEMQAKE----EEMQKITERQQKAETELKELEQKHT-QLAEEKTLLQEQLQAETELYAES 906
Query: 871 GVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGS---- 926
+++ KK+E+ + + +E+ L + ++ QQL E +
Sbjct: 907 EEMRVRLAA------KKQELE-----EILHEMEARLEEEEDRRQQLQAERKKMAQQMLDL 955
Query: 927 ---LQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV----VNG 979
L++ ++ +KL+LEK T E + + + + +++ +L +E + L V N
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDDQNSKLSKERKLLEERVSDLTTNL 1015
Query: 980 VEKENRSK----------STLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLK 1029
E+E ++K S ++ L+ + + ++ Q ++ K+ + + ++DL+
Sbjct: 1016 AEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 1030 DAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFG 1089
A+ + + L + L EI N ++K + E G++S L DL+ E
Sbjct: 1076 -AQIAELKMQLAKKEEELQAALARLDEEIAQKNNALKK--IRELEGHISDLQEDLDSERA 1132
Query: 1090 VLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTK 1149
K E + L E +E + EL + + A+ + + LK +E T+
Sbjct: 1133 ARNK----AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 1150 IKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLN 1209
E Q+ E + H + +E L E E + K L + +Q +E A +
Sbjct: 1189 SHE---AQVQEMRQK---HTQAVEELTEQLEQFK-RAKANLDKSKQTLEKENA------D 1235
Query: 1210 KENEFKLWENEAAAFYHDLQMSSICLALLESKVS-------ELTG-VCKILDDESSAKSL 1261
E ++ H + + L L+SK S EL+ V K+ ++ S +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGM 1295
Query: 1262 ENEHMREIISLLESEIGGLKEQLSAYVPLVSS-LKEDFNSLEHISLLWTKRNSVVGNGAQ 1320
NE + I L + ++ L QL L+ ++ N + L +RNS+ Q
Sbjct: 1296 LNEAEGKAIKLAK-DVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQD---Q 1351
Query: 1321 KDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLT 1380
D +E H S + + D L + I +MEE K+R+ QK +
Sbjct: 1352 LDEEMEAKQNLERHVSTLN---IQLSDSKKKLQDFASTIE-----VMEEGKKRL-QKEME 1402
Query: 1381 TESTPYSSLEIATYPKVENRKKEIEL-VEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQ 1439
S Y + A Y K+E K ++ +++ V D ++ R+ L N++ +
Sbjct: 1403 GLSQQYEE-KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ------------LVSNLEKK 1449
Query: 1440 NSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIE-K 1498
K+ ++ + S +Y + + E +
Sbjct: 1450 QKKF------------------------------DQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 1499 ELGVDKLELSKSVKEKTE--DDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQG 1556
E L L+++++E E ++ R + L ++ + L K D+ K +KSK+
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK---DDVGKNVHELEKSKRA 1536
Query: 1557 NDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQ 1616
+ + E +K +EE E+ V ++ N++ +R++ R + K + +
Sbjct: 1537 LETQMEEMKTQLEESEDDVQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 1617 NIQYILLKLAEENNNKVKNRISRK 1640
+ +L +E + ++K
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKK 1620
Score = 54.7 bits (130), Expect = 2e-06
Identities = 79/358 (22%), Positives = 151/358 (42%), Gaps = 61/358 (17%)
Query: 39 KVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHK 98
K++ +K +E +ADS + E K+ +L +++F R EL A
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--------------ELDDARA 1666
Query: 99 TMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLREAL 158
+ E F S S L E +A ER+ ++++ E + L E L
Sbjct: 1667 SRDEIFATSKENEKKAKSLEADLMQLQEDLAAA---------ERARKQADLEKEELAEEL 1717
Query: 159 AKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLK 218
A S ++ L + + ++++E +L + Q N + DR +A +Q E L L +
Sbjct: 1718 ASSLSGRNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATER 1777
Query: 219 A----DKDAGEVLYNQCLE------------------TIARLESMLSQ-KDNIEAK-NLK 254
+ ++ A + L Q E T+A LE+ ++Q ++ +E + K
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREK 1837
Query: 255 QELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLA 314
Q T+ + QKD K+ E + +E++ +AE+ +Q E+ +V+ L++ L
Sbjct: 1838 QAATKSLKQKD------KKLKEVLLQVEDERKMAEQ----YKEQAEKGNTKVKQLKRQLE 1887
Query: 315 EMNEERDSLSVLYHHCLEKISKM--ENEILHVQENAEQLKNKIEKEAEKLEISEKHRG 370
E EE ++ ++ + NE + + NA LK+K+ + E + + G
Sbjct: 1888 EAEEESQCINANRRKLQRELDEATESNEAMGREVNA--LKSKLRRGNEASFVPSRRAG 1943
>MYHA_HUMAN (P35580) Myosin heavy chain, nonmuscle type B (Cellular
myosin heavy chain, type B) (Nonmuscle myosin heavy
chain-B) (NMMHC-B)
Length = 1976
Score = 146 bits (369), Expect = 4e-34
Identities = 241/1112 (21%), Positives = 457/1112 (40%), Gaps = 190/1112 (17%)
Query: 235 IARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRM 294
+ R E L KD E +K++ T+V + + + +++Q +LE K LAE+
Sbjct: 847 VTRQEEELQAKDE-ELLKVKEKQTKVEGELEEMERKHQQ------LLEEKNILAEQLQA- 898
Query: 295 LNDQIERTEL--EVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLK 352
TEL E E +R LA +E + + H LE S++E E +E + L+
Sbjct: 899 ------ETELFAEAEEMRARLAAKKQELEEIL----HDLE--SRVEEE----EERNQILQ 942
Query: 353 NKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMH 412
N+ +K ++ E+ E + Q LQLE +I + E+L L+
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL-----------LLE 991
Query: 413 GEHSNFIQ----IESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQ 468
++S FI+ +E + ++ +++ +NLA +++ DLE
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE----------- 1040
Query: 469 GIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKD 528
LKK++ +L++ K KL+ E ++ LQ + ++K
Sbjct: 1041 -----------------ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 529 DIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKD 588
+ E Q L + L+ N+ VR+LQ + L+E + E + + ++ +D
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 589 MNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQII 648
++E L E L D LD + + Q + E K L +E +Q+Q +
Sbjct: 1144 LSEEL------EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 649 TE----SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSML 704
+ +++++ E ++ ++ + +GL + +L K+L K +++R L
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 705 ISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL----------FASILVQK 754
+Q++ + K+S ++ L EK + ++ + ++ +EE AS+ Q
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 755 ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELE 814
++ + NL + +R L+EE+ + + E+E + N + ++ LQ+ + + +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 815 LKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLH-RIRKFKMDIHKVCGVL 873
K L E L EA K K++ + E+ L Q +EE+ L + ++ K K
Sbjct: 1378 KKVDDDLGTIESLEEAKK---KLLKDAEA--LSQRLEEKALAYDKLEKTK---------- 1422
Query: 874 QIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSE 933
N +++E ++ LD + S+L K Q++ QLL E + + +
Sbjct: 1423 ---------NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Query: 934 GEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV-------------VNGV 980
E EK+T E+ + + K E +N+QLR ++ V+ +
Sbjct: 1474 AEAEAREKETKALSLARALEEAL---EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 981 EKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENS 1040
EK R AL+ ++ E+R + ++E D K L N+ +K A+ E
Sbjct: 1531 EKSKR------ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK-----AQFERD 1579
Query: 1041 VMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEA 1100
+ D +N +KR L + + L D ++ + + + E
Sbjct: 1580 LQTRD---------------EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI 1624
Query: 1101 ENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELK-------MEQEESTKIKEN 1153
+ L IE +K E+ K+L+ + ++ R +EE + + +ES K ++
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 1154 LDRQILEQSENCMNHKKEIEHLNEANETLQFEM-------KTLLHEVE---------QHR 1197
L+ +IL+ E + ++ H + + L E+ LL E +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 1198 VREEALNLELLNKE-----NEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKIL 1252
+ EE N+ELLN + E AA Q S LE + EL K+
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK--AKLQ 1802
Query: 1253 DDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
+ E + KS + IS LE++IG L+EQL
Sbjct: 1803 ELEGAVKS----KFKATISALEAKIGQLEEQL 1830
Score = 144 bits (363), Expect = 2e-33
Identities = 241/1239 (19%), Positives = 509/1239 (40%), Gaps = 175/1239 (14%)
Query: 38 TKVKSMIKLIEEEADSFARRAEMYY--KKRPELMKLVEEFYRAYRALAERYDHAMGELRH 95
TKVK ++++ +E + A+ E+ +K+ ++ +EE R ++ L E + +L+
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 96 AHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLR 155
+ EA A + D ES R++ + ++ +Q L
Sbjct: 899 ETELFAEAEEMRARLAAKKQE-LEEILHDLESRVEEEE-ERNQILQNEKKKMQAHIQDLE 956
Query: 156 EALAKMQSDKDALFLQYQESLENLSKMETDL-------NKAQNNARGLDDRASEAEIQVE 208
E L + + + L L+ + + KME ++ +K + ++DR +E Q+
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 209 ILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVL 268
+E L ++ EV+ + ++E + K+E TR ++K
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMIS-----------------DLEERLKKEEKTRQELEKAKRK 1059
Query: 269 LQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEE-------RD 321
L + + L DQI + +++ L+ LA+ EE D
Sbjct: 1060 L-------------------DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD 1100
Query: 322 SLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQL 381
++ ++ L+ + +++ +I +QE+ E K K +EK + L + + L+
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNK-------AEKQKRDLSEELEALKT 1153
Query: 382 EAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRN 441
E E+ + A++ ++ E+ L+ + E N E+ +Q +++ ++ + +E
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH---EAQIQDMRQRHATALEE--- 1207
Query: 442 LALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEI 501
L+ +L+ +LE +KQ + + + + E K L ++ S KK ++
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV------ 1261
Query: 502 KEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVR-D 560
+E H E + L+ E + +Q+ + +LE+ + G+ AAS+
Sbjct: 1262 -----QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 561 LQNENFMLKETCKKE----------HSEKEALREKSKDMNEVLMENACMEFSLLGLNDEL 610
LQ+ +L+E +++ EK +L+E+ ++ E +E +L L +L
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN---LEKQVLALQSQL 1373
Query: 611 DGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAK 670
+ V + + L+E K L + L +L+ + K+ + L++ L D
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 671 IEFEGLRIKSGDLEDCCK----LLNDEKN---NLQNERSMLISQLEIVEEKLSNLEKKVT 723
++ + R + +LE K LL +EK+ ER ++ E K +L + +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 724 NLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQR 783
E + E+ + +E+L +S K++ + H E LE V EE R
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSS----KDDVGKNVHELEKSKRALEQQV----EEMR 1545
Query: 784 LGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELES 843
E E EL +A++ + + ++ ++ L T E+ E + K + ELE+
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERD--LQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 844 ENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLE 903
E ++ ++ L K KM+I QI++ +E+ K+ + L+
Sbjct: 1604 E--LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ----------LRKLQ 1651
Query: 904 SSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKV 963
+ + Q E ++ + QS+ + KL K++E E ++E+ ++ +
Sbjct: 1652 AQMKDYQRELEEARASRDEIFA-----QSKESEKKL--KSLEAEILQLQEELASSERARR 1704
Query: 964 ELLEENRQLRIEVVNG-------VEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLD 1016
+E +L E+ N ++++ R ++ +A L+ E+ E + ++ + K
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1017 EKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGN 1076
+ ++L ++L +S+A+ ++ L N L ++ E V+ +
Sbjct: 1765 QVDTL---NAELAAERSAAQKSDNA--RQQLERQNKELKAKLQELEGAVKSK-------- 1811
Query: 1077 LSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRH 1136
+ L + G L + E + E N+ + R +K+L E+ +++ + RH
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE-------DERRH 1864
Query: 1137 IEELKMEQEESTKIKENLDRQILEQSE-----NCMNHK--KEIEHLNEANETLQFEMKTL 1189
++ K + E++ + L RQ+ E E N K +E++ EANE L E+ TL
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Query: 1190 LHEVE-------------QHRVREEALNLELLNKENEFK 1215
+ + + ++ E +LEL + + E K
Sbjct: 1925 KNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESK 1963
Score = 93.6 bits (231), Expect = 4e-18
Identities = 178/917 (19%), Positives = 383/917 (41%), Gaps = 101/917 (11%)
Query: 781 EQRLGKVEFEQELDRVVNAQI--EMFILQNCIEELELK--NFVLLTE--CEKLVEASKFS 834
E+ + +E + L R+ ++I +L + EE +LK + ++ + C + F+
Sbjct: 748 ERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGCLARKAFA 807
Query: 835 DKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISR 894
K +L + ++Q +L R ++ KV +LQ+ + E++ ++ + +
Sbjct: 808 KKQ-QQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ---EEELQAKDEELLK 863
Query: 895 ILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQ---SEGEKLKLEKKTVEQEFENM 951
+ +K +E L + + ++QQLL E ++L LQ +E E+++ +QE E +
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 952 -----------REQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIEL 1000
E+N ILQ +K ++ + L ++ + + +A++ ++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 1001 RQTNQVFQEENGKMLDEKNSLCRNV----SDLKDAKSSAEDENSVMFHDVLALSNLN--L 1054
+ + +++N K + EK + + S L + + A++ + + +S+L L
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 1055 VYEIFFTENMVE-KRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMD 1113
E + + + KR L +L +L + L+ KE E L ++ R D
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE---LQGALARGD 1100
Query: 1114 KELLEMDKRLKAA---ETSNAEFSRHIEELKMEQEESTKIKENLDRQI------LEQSEN 1164
E L + LK + AE E K + ++ K K +L ++ LE + +
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 1165 CMNHKKEI-----EHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWEN 1219
++E+ + + E + L+ E K +++ R R A LE L+++ E
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH-ATALEELSEQLE------ 1213
Query: 1220 EAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGG 1279
+A F +L+ + LE+ EL K+L + E+EH R+ + E+
Sbjct: 1214 QAKRFKANLEKNK---QGLETDNKELACEVKVLQQVKA----ESEHKRKKLDAQVQELHA 1266
Query: 1280 -LKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSAR 1338
+ E V L + N L+++S L + A+ +E+ L Q +
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL-----QDTQ 1321
Query: 1339 ENEIVLIPDGVSDLLTLQTRIRAVEK----IMMEELKRRVKQKSLTTESTPYSSLEIATY 1394
E L+ + L L +RIR +E+ + ++ + +K+L + S T
Sbjct: 1322 E----LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 1395 PKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKY--LKREHRRTN 1452
KV++ IE +EE K +LL L + ++++ Y L++ R
Sbjct: 1378 KKVDDDLGTIESLEE-----------AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 1453 DHVLELCENNEHEPLSAPTVDHA------MICHRSDDSGRYLNYSSELDIE-KELGVDKL 1505
+ +L + +H+ A ++ ++ S RY + E +E L
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 1506 ELSKSVKEKTE--DDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYET 1563
L+++++E E ++ R ++L +D + L K D+ K +KSK+ + + E
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSK---DDVGKNVHELEKSKRALEQQVEE 1543
Query: 1564 VKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYILL 1623
++ +EE+E+ + ++ N++ + +R++ R + K + ++ ++ +
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 1624 KLAEENNNKVKNRISRK 1640
+L +E + S+K
Sbjct: 1604 ELEDERKQRALAVASKK 1620
Score = 80.9 bits (198), Expect = 3e-14
Identities = 99/512 (19%), Positives = 211/512 (40%), Gaps = 40/512 (7%)
Query: 34 TDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGEL 93
++++ K K +L+ EE AR AE + E + + RAL E + A E
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE-AKEEF 1502
Query: 94 RHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS-EESNGEVQ 152
+K + + +++ G + E S R + + R+ EE E+Q
Sbjct: 1503 ERQNKQLRADMED----LMSSKDDVGKNVHELEK--SKRALEQQVEEMRTQLEELEDELQ 1556
Query: 153 TLREALAKMQSDKDALFLQYQESLE-----NLSKMETDLNKAQNNARGLDDRASEAEIQV 207
+A +++ + A+ Q++ L+ N K + + + L+D + + V
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 208 EILKE---SLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQK 264
K+ L L+A +A ++ ++ + +L++ + K+ ++EL +
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM--------KDYQRELEEARASR 1668
Query: 265 DTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLS 324
D + Q K+ +K+ LE +I +E E E + L + + +L
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 325 VLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAE 384
+I+++E E+ Q N E L ++ K +++ + Q +++
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ----KSD 1784
Query: 385 NLVQRIASKDHELLEKHTEIE-----RLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQ 439
N Q++ ++ EL K E+E + + + + Q+E L+ K + + K
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 440 RNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLK 499
R +LK + ++D +KE+M+ + N + +L R L++ + E ++
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQME---KANARMKQLK----RQLEEAEEEATRAN 1897
Query: 500 EIKEKLEREFHTSTEESNVLQRETHQIKDDIQ 531
+ KL+RE +TE + L RE +K+ ++
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
>MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular
myosin heavy chain, type A) (Nonmuscle myosin heavy
chain-A) (NMMHC-A)
Length = 1961
Score = 145 bits (367), Expect = 7e-34
Identities = 248/1166 (21%), Positives = 484/1166 (41%), Gaps = 140/1166 (12%)
Query: 177 ENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIA 236
+ L E +L K + ++R +E E L +QL+ A L + E A
Sbjct: 845 DELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTELCAEAEELRA 904
Query: 237 RLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLN 296
RL + + + I +L+ + + + + K+ + I LE + L EE S
Sbjct: 905 RLTAKKQELEEI-CHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQ--LEEEESARQK 961
Query: 297 DQIER--TELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAE---QL 351
Q+E+ TE +++ L ++ M ++ L+ +++++ +++ +E ++ +L
Sbjct: 962 LQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTDLMEEEEKSKSLAKL 1021
Query: 352 KNK----IEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEI--- 404
KNK I E+L EK R LEK+ + L+ ++ +L +IA ++ E ++
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 405 -ERLQTLMHGEHSNFIQIESALQALQKLYSQ-----------------SQKEQRNLALEL 446
E LQ + Q AL+ +++L +Q ++K++R+L EL
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQKRDLGEEL 1141
Query: 447 KYGLLLLKD----------LELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQME-- 494
+ L+D L ++ ++ +E+ HE R Q +E
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 495 ---ISKLKEIKEKLEREFHTSTEESNVLQRETH---QIKDDIQHLNERYQAMLEQLQ--- 545
+ + K +K LE+ T E L E Q K D +H ++ +A L++LQ
Sbjct: 1202 AEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQVKF 1261
Query: 546 SLGLNPNSFAA-----------SVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLM 594
S G + A SV L N++ K+ S AL + +D E+L
Sbjct: 1262 SEGERVRTELADKVSKLQVELDSVTGLLNQSDSKSSKLTKDFS---ALESQLQDTQELLQ 1318
Query: 595 ENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQK 654
E + SL +++ + + +E Q + +E K L + +TL +Q+ + + M+
Sbjct: 1319 EENRQKLSLSTKLKQMEDEKNSFRE--QLEEEEEEAKRNLEKQIATLHAQVTDMKKKMED 1376
Query: 655 ILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEK 714
+ E++ + + EGL + + L K LQ E L+ L+ +
Sbjct: 1377 GVGCLETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1436
Query: 715 LSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN-LEN 773
+SNLEKK ++ A+ +K + EE + E + K + LA LE
Sbjct: 1437 VSNLEKKQKKFDQLLAE---EKTISAKYAEE-----RDRAEAEAREKETKALSLARALEE 1488
Query: 774 IVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKF 833
+ E +RL K +F E++ +++++ + + + ELE N L E+ VE K
Sbjct: 1489 AMEQKAELERLNK-QFRTEMEDLMSSKDD---VGKSVHELEKSNRAL----EQQVEEMKT 1540
Query: 834 SDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPIS 893
+ ELE E +Q E+ K +++++ Q + D G +E +E+
Sbjct: 1541 Q---LEELEDE--LQATED-------AKLRLEVNLQAMKAQFERDLQGRDEQSEEK--KK 1586
Query: 894 RILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMRE 953
+++ ++ +E+ L +++ + L L+ ++ + ++ ++ ++
Sbjct: 1587 QLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQA 1646
Query: 954 QNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGK 1013
Q KD + +++ R R E++ KEN K L +++AEMI+L++ + +
Sbjct: 1647 Q----MKDCMRDVDDTRASREEIL-AQAKENEKK--LKSMEAEMIQLQEELAAAERAKRQ 1699
Query: 1014 MLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEH 1073
E++ L +++ K + E ++AL L E TE ++ R +
Sbjct: 1700 AQQERDELADEIAN-SSGKGALALEEKRRLEALIALLEEELEEEQGNTE-LINDRLKKAN 1757
Query: 1074 LGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKE----LLEMDKRLKAA-ET 1128
L + +N DLN E +KN EN + +ER +KE L EM+ +K+ +
Sbjct: 1758 L-QIDQINTDLNLERSHAQKN------ENA--RQQLERQNKELKAKLQEMESAVKSKYKA 1808
Query: 1129 SNAEFSRHIEELKMEQEESTKIKENLDRQ----------ILEQSENCMNHKKEIEHLNEA 1178
S A I +L+ + + TK ++ +Q +L Q E+ + ++ + +
Sbjct: 1809 SIAALEAKIAQLEEQLDNETKERQAASKQVRRAEKKLKDVLLQVEDERRNAEQFKDQADK 1868
Query: 1179 NETLQFEMKTLLHEVEQHRVREEA----LNLELLNKENEFKLWENEAAAFYHDLQMSSIC 1234
T ++K L E E+ R A L EL + E ++ + L+ +
Sbjct: 1869 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDMP 1928
Query: 1235 LALLESKVSELTGVCKILDDESSAKS 1260
+ V + TG C D+E K+
Sbjct: 1929 FVVTRRIVRKGTGDCS--DEEVDGKA 1952
Score = 115 bits (287), Expect = 1e-24
Identities = 235/1125 (20%), Positives = 447/1125 (38%), Gaps = 163/1125 (14%)
Query: 593 LMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESM 652
L+ + E LL EL +R + ++ +S L EK L QLQ TE
Sbjct: 837 LLNSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTELC 896
Query: 653 QKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLE--- 709
+ E L + + L + + E+ C+ L EK +Q L QLE
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEE 956
Query: 710 -----------IVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHS 758
E KL LE+ +E++ + K+K+ ++V E F + L+++E S
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAE-FTTDLMEEEEKS 1015
Query: 759 NH----KHSSEARLANL-ENIVRVLQEEQRLGKVEFEQELDRV--------VNAQIEMFI 805
K+ EA + +L E + R ++ Q L K + E D + AQI
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 806 LQNCIEELELKNFVLLTECEKLVEASKFSDKVISELE---SENLMQLIEEEFLLHRIRKF 862
+Q +E EL+ L E+ + K I ELE SE L E ++ K
Sbjct: 1076 MQLAKKEEELQ--AALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQ 1133
Query: 863 KMDIHKVCGVLQIDSDGGGDNEIKKEEIPISR-----ILDKIESLESSLVKSQEENQQLL 917
K D+ + L+ + + D+ ++E+ R IL K +LE + + Q++
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKK--TLEDEAKTHEAQIQEMR 1191
Query: 918 VENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMR-----EQNVILQ------------- 959
++S + L + + +++K + +Q EN R E +LQ
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVE 1251
Query: 960 --------------KDKVELLEENRQLRIEV--VNGVEKENRSKSTLAALQAEMIE--LR 1001
+ + EL ++ +L++E+ V G+ ++ SKS+ +E L+
Sbjct: 1252 AQLQELQVKFSEGERVRTELADKVSKLQVELDSVTGLLNQSDSKSSKLTKDFSALESQLQ 1311
Query: 1002 QTNQVFQEENGKML----------DEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSN 1051
T ++ QEEN + L DEKNS + + ++ ++ H +
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEEAKRNLEKQIATLHAQVTDMK 1371
Query: 1052 LNLVYEIFFTENMVE-KRALCEHLGNLSHLNNDLNQEFGVLRKNFE--VKEAENVYLN-- 1106
+ + E E KR L + L LS + + L K +E +++ ++
Sbjct: 1372 KKMEDGVGCLETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1431
Query: 1107 ---ESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSE 1163
+S+ ++K+ + D+ L +T +A+++ + + E E KE + E
Sbjct: 1432 HQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE----KETKALSLARALE 1487
Query: 1164 NCMNHKKEIEHLNEANETLQFEMKTLL----------HEVEQ-HRVRE---EALNLELLN 1209
M K E+E LN+ T EM+ L+ HE+E+ +R E E + +L
Sbjct: 1488 EAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSNRALEQQVEEMKTQLEE 1544
Query: 1210 KENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREI 1269
E+E + E+ +LQ A+ +L G D++S K + + +R++
Sbjct: 1545 LEDELQATEDAKLRLEVNLQ------AMKAQFERDLQG----RDEQSEEK--KKQLVRQV 1592
Query: 1270 ISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLE-HISLLWTKRNSVVGNGAQKDVVIETC 1328
+E+E+ ++Q S + L+ D LE HI R + + ++ C
Sbjct: 1593 RE-MEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDC 1651
Query: 1329 LRKHSHQSARENEIVL--------IPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLT 1380
+R A EI+ + ++++ LQ + A E+ + + R +
Sbjct: 1652 MRDVDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1711
Query: 1381 TESTPYSSLEIATYPKVENRKKE--IELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDD 1438
S+ +L + E R+ E I L+EE + + + RL ++ +D+ D
Sbjct: 1712 ANSSGKGALALE-----EKRRLEALIALLEEELEEEQGNTELINDRLKKANLQIDQINTD 1766
Query: 1439 QNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEK 1498
N L+R H + N++ + E E L A + + + +S +E
Sbjct: 1767 LN---LERSHAQKNENARQQLERQNKE-LKAK-------LQEMESAVKSKYKASIAALEA 1815
Query: 1499 ELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGND 1558
++ + +L KE+ K ++ +KL + + ++D ++ E K
Sbjct: 1816 KIAQLEEQLDNETKERQAASK-----QVRRAEKKLKDVLLQVEDERRNAEQFKDQADKAS 1870
Query: 1559 IEYETVKRHIEEVEEAVMQQVSINDQMAKNVE---EGASSLDREI 1600
+ +KR +EE EE + + ++ + +E E A +++RE+
Sbjct: 1871 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1915
Score = 109 bits (273), Expect = 6e-23
Identities = 179/928 (19%), Positives = 377/928 (40%), Gaps = 141/928 (15%)
Query: 438 EQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISK 497
E R +E L+ + L+L +E++Q E EL T KKQ++E
Sbjct: 865 ENRLTEMETMQSQLMAEKLQL-----QEQLQAKTELCAEAEELRARLTA--KKQELE--- 914
Query: 498 LKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAAS 557
EI LE E LQ E +++ +IQ L E+ + Q L L + A
Sbjct: 915 --EICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK 972
Query: 558 VRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTV 617
++ L+ + ++++ K EK+ L ++ + LME SL L ++ + + +
Sbjct: 973 LKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTDLMEEEEKSKSLAKLKNKHEAMITDL 1032
Query: 618 KEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLR 677
+E ++ +EEK Q Q + ++ +K+ ++T L +++ + + L+
Sbjct: 1033 EE-----RLRREEK------------QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 678 IKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKV-------TNLEEKYA 730
++ E+ + +++M + ++ +E ++S L++ + E++
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQKR 1135
Query: 731 DVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRV----LQEEQRLGK 786
D+ ++ E+ ++E+ S Q+E S + LE+ + +QE ++
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHS 1195
Query: 787 VEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENL 846
E+ +++ + L+ + LE + L E + L++ S+ ++E++
Sbjct: 1196 QAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQ-- 1253
Query: 847 MQLIEEEF---------LLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILD 897
+Q ++ +F L ++ K ++++ V G+L N+ + +++
Sbjct: 1254 LQELQVKFSEGERVRTELADKVSKLQVELDSVTGLL---------NQSDSKSSKLTKDFS 1304
Query: 898 KIES-LESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLE----KKTVEQE----- 947
+ES L+ + QEEN+Q L ++ L + S E+L+ E K+ +E++
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEEAKRNLEKQIATLH 1364
Query: 948 ----------------FENMREQNVILQKDKVELLEENRQLRIEVVNGVEK-ENRSKSTL 990
E E LQKD +E L + + ++ + +EK + R + L
Sbjct: 1365 AQVTDMKKKMEDGVGCLETAEEAKRRLQKD-LEGLSQRLEEKVAAYDKLEKTKTRLQQEL 1423
Query: 991 AALQAEMIELRQTNQVFQEENGK---MLDEKNSLCRNVSDLKD-AKSSAEDENSVMFHDV 1046
L ++ RQ+ +++ K +L E+ ++ ++ +D A++ A ++ +
Sbjct: 1424 DDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1483
Query: 1047 LALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLN-NDLNQEFGVLRKNFEVKEAENVYL 1105
AL E +E++A E L DL + K+ E N L
Sbjct: 1484 RAL------------EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSNRAL 1531
Query: 1106 NESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKME--------QEESTKIKENLDRQ 1157
+ +E M +L E++ L+A E + +++ +K + E+S + K+ L RQ
Sbjct: 1532 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1591
Query: 1158 ILE----------QSENCMNHKKEIE--------HLNEANET----------LQFEMKTL 1189
+ E Q M +K++E H++ AN+ LQ +MK
Sbjct: 1592 VREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDC 1651
Query: 1190 LHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVC 1249
+ +V+ R E + + E + K E E +L + + + EL
Sbjct: 1652 MRDVDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1711
Query: 1250 KILDDESSAKSLENEHMREIISLLESEI 1277
+ + E + +I+LLE E+
Sbjct: 1712 ANSSGKGALALEEKRRLEALIALLEEEL 1739
Score = 107 bits (267), Expect = 3e-22
Identities = 164/859 (19%), Positives = 372/859 (43%), Gaps = 102/859 (11%)
Query: 146 ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEI 205
E ++ L+E L ++ ++ Q ++ E L ++T+L ++ + S+ E
Sbjct: 1108 ELETQISELQEDLESERACRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
Query: 206 QVEILKESLM-QLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQK 264
+V ILK++L + K + + + + + + L L Q ++A L++ + ++
Sbjct: 1168 EVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA-TLEKAKQTLENER 1226
Query: 265 DTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLS 324
+ + K L+ E+K E + L + E L ++++ E DS++
Sbjct: 1227 GELANEVKALLQGKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVSKLQVELDSVT 1286
Query: 325 VLYHHCLEKISKMENEILHVQENAEQLKNKIEKE-AEKLEISEKHRGML-EKSNQNLQLE 382
L + K SK+ + ++ + + +++E +KL +S K + M EK++ QLE
Sbjct: 1287 GLLNQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSFREQLE 1346
Query: 383 AE------NLVQRIASKDHELLEKHTEIE--------------RLQTLMHGEHSNFIQIE 422
E NL ++IA+ ++ + ++E RLQ + G +
Sbjct: 1347 EEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQRLEEKV 1406
Query: 423 SALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNF 482
+A L+K ++ Q+E +L ++L + + +LE ++ F + ++ E KT+
Sbjct: 1407 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQ----LLAEEKTIS---- 1458
Query: 483 SSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQR---ETHQIKDDIQHLNERYQA 539
+K E +++ E E ++ L R E + K +++ LN++++
Sbjct: 1459 -------------AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1505
Query: 540 MLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACM 599
+E L S + + SV +L+ N L++ ++ ++ E L ++ + + + +
Sbjct: 1506 EMEDLMS---SKDDVGKSVHELEKSNRALEQQVEEMKTQLEELEDELQATEDAKLR---L 1559
Query: 600 EFSLLGLNDELD-GLRG----TVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQK 654
E +L + + + L+G + ++ +Q + ++E ++ L DE+ Q I + +K
Sbjct: 1560 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER----KQRSIAMAARKK 1615
Query: 655 ILENNTVLEKSLSDAKIEFE----GLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEI 710
+ + LE + A E LR ++DC + ++D + + R +++Q +
Sbjct: 1616 LEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDCMRDVDDTRAS----REEILAQAKE 1671
Query: 711 VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLAN 770
E+KL ++E ++ L+E+ A E+ K A + +EL I N S +
Sbjct: 1672 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI----ANSSGKGALALEEKRR 1727
Query: 771 LENIVRVLQE--EQRLGKVEFEQELDRVVNAQIEMFIL------------QNCIEELELK 816
LE ++ +L+E E+ G E + + N QI+ +N ++LE +
Sbjct: 1728 LEALIALLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1787
Query: 817 NFVLLTECEKLVEASKFSDKV--------ISELESENLMQLIEEEFLLHRIRKFKMDIHK 868
N L + +++ A K K I++LE + + E + ++R+ + +
Sbjct: 1788 NKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQAASKQVRRAEKKLKD 1847
Query: 869 VCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQ 928
V +LQ++ + + K + + +++ L+ L +++EE Q+ L L+
Sbjct: 1848 V--LLQVEDERRNAEQFKDQ---ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1902
Query: 929 QHQSEGEKLKLEKKTVEQE 947
+ + E +++ +
Sbjct: 1903 DATETADAMNREVSSLKNK 1921
>MYHD_HUMAN (Q9UKX3) Myosin heavy chain, skeletal muscle, extraocular
(MyHC-eo)
Length = 1938
Score = 145 bits (365), Expect = 1e-33
Identities = 199/1039 (19%), Positives = 443/1039 (42%), Gaps = 94/1039 (9%)
Query: 282 ENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEI 341
E ++A +E+ +++ R+E + L + + + +E++ L L+ S+ EN +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQ------LQVQSETEN-L 902
Query: 342 LHVQENAEQL-KNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEK 400
+ +E E L K+KI EA+ E++E+ E+ N L + NL + +S ++ +
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEE-EEMNSELVAKKRNLEDKCSSLKRDIDDL 961
Query: 401 HTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSK 460
+ +++ H + + + AL++ S+ KE+++L + L DL++ +
Sbjct: 962 ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQ---TLDDLQVEE 1018
Query: 461 QDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQ 520
+++ G+++ N L + SL++++ + L+ K KLE + S E L+
Sbjct: 1019 ----DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 521 RETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKE 580
E QI++ ++ + ++ ++ F +++LQ L+E + EH+ +
Sbjct: 1075 NEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRA 1134
Query: 581 ALREKSKDMNEVLME-NACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEE--------- 630
+ ++ D+ L E + +E + + +++ + E Q+ + L+E
Sbjct: 1135 KIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 631 --KSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCK 688
+ AD + L Q+ + QK+ + + L+ + D E L ++E C+
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254
Query: 689 LLNDEKNNLQ---NERSMLISQLEIVEEKL----SNLEKKVTNLEEKYADVEKDKESAVN 741
+ D+ + ++ +++ LI L + + +L L +V E + + K K++
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ 1314
Query: 742 QVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQI 801
Q+EEL + + + + H+ ++ + + ++R EE++ K E ++ L + N+++
Sbjct: 1315 QLEELKRQMEEETKAKNAMAHALQSSRHDCD-LLREQYEEEQEAKAELQRALSK-ANSEV 1372
Query: 802 EMFILQ------NCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFL 855
+ + EELE L ++ E ++ ++ + LE E E L
Sbjct: 1373 AQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 856 LHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQ 915
+ + + H C L D + + + ++ K++ ++ L +Q+E++
Sbjct: 1433 MRDLER----SHTACATL--------DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS 1480
Query: 916 LLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQ------NVILQKDKVELLEEN 969
L E + + ++ + E L+ E K +++E ++ EQ N+ + +L+E+
Sbjct: 1481 LSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQE 1540
Query: 970 R---QLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVS 1026
+ Q+ +E V G + SK L+ ++ +V +++ +E L RN
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD-----EEIEQLKRNSQ 1595
Query: 1027 DLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQ 1086
+A S D +D L L + L E L H N + +
Sbjct: 1596 RAAEALQSVLDAEIRSRNDALRLKK-------------KMEGDLNEMEIQLGHSNRQMAE 1642
Query: 1087 EFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEE 1146
LR + ++L++++ R +++L E +L E N +EE+K+ E+
Sbjct: 1643 TQRHLRTVQGQLKDSQLHLDDAL-RSNEDLKE---QLAIVERRNGLLLEELEEMKVALEQ 1698
Query: 1147 STKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLE 1206
+ + + ++++L+ S+ ++ L+ N +L K L ++ Q + E E
Sbjct: 1699 TERTRRLSEQELLDASD-------RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751
Query: 1207 LLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDE-SSAKSLENEH 1265
N E + K +AA +L+ A LE L K L A+ L +
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1811
Query: 1266 MREIISLLESEIGGLKEQL 1284
++ I LE+ + L+ +L
Sbjct: 1812 GKKQIQKLENRVRELENEL 1830
Score = 137 bits (344), Expect = 3e-31
Identities = 237/1168 (20%), Positives = 476/1168 (40%), Gaps = 135/1168 (11%)
Query: 489 KKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLG 548
++ + E+++ + +++LE + + +E N LQ + +++ ER + +++ L
Sbjct: 861 ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE 920
Query: 549 LNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLND 608
L+ E M E K+ + ++ +D+++ +E +L +
Sbjct: 921 AKVKELTER---LEEEEEMNSELVAKKRNLEDKCSSLKRDIDD-------LELTLTKVEK 970
Query: 609 ELDGLRGTVKEIQQFCQVLQEEKSILADEKSTL-------LSQLQIITESMQKILENNTV 661
E VK + + L+E S L EK +L L LQ+ + + +++ N
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 662 LEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKK 721
LE+ D + E + DLE + L + Q L ++ + +EEKL E +
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKKEFE 1090
Query: 722 VTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARL-ANLENIVRVLQE 780
++ L+ + D + +++EL A I + E +H+ A++ ++ R L+E
Sbjct: 1091 LSQLQARIDDEQVHSLQFQKKIKELQARI-EELEEEIEAEHTLRAKIEKQRSDLARELEE 1149
Query: 781 -EQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVIS 839
+RL +E +AQIEM N E E + + + E+ + + +
Sbjct: 1150 ISERL------EEASGATSAQIEM----NKKREAEFQK--MRRDLEEATLQHEATAATLR 1197
Query: 840 ELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKI 899
+ +++++ +L E+ L R+++ K++ K ++ID + K + I R +
Sbjct: 1198 KKQADSVAELGEQIDNLQRVKQ-KLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV 1256
Query: 900 ESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQ 959
E S + E+ QL+ + ++ LQ E EK+++ + L
Sbjct: 1257 EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ----------LT 1306
Query: 960 KDKVELLEENRQLRIEVVNGVEKENRSKSTLA-ALQAEMIELRQTNQVFQEENGKMLDEK 1018
K K L ++ +L+ + +E+E ++K+ +A ALQ+ + + ++EE + +
Sbjct: 1307 KSKQALTQQLEELKRQ----MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362
Query: 1019 NSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVE-KRALCEHLGNL 1077
+L + S++ K+ E + I TE + E K+ L + L
Sbjct: 1363 RALSKANSEVAQWKTKYETD------------------AIQRTEELEEAKKKLAQRLQEA 1404
Query: 1078 SHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHI 1137
N + L K + + E L +ER +DK+ + + AE+ + +
Sbjct: 1405 EEKTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 1138 EELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQ-- 1195
+E + E E + K +L ++ + ++E L N+ LQ E+ L ++ +
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 1196 HRVREEALNLELLNKEN---EFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKIL 1252
++E +L+ +E + L E E + + + ++ + L L + K SEL K++
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK-SELDR--KVI 1581
Query: 1253 DDESSAKSLENEHMR---EIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHIS--LL 1307
+ + + L+ R + S+L++EI + L + L E L H + +
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 1308 WTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMM 1367
T+R+ G KD + S++ +E ++ L L+ A+E+
Sbjct: 1642 ETQRHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ--- 1698
Query: 1368 EELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIEL--------VEENVFD-RNSWR 1418
E RR+ ++ L S L + + N KK++E VE ++ + RN+
Sbjct: 1699 TERTRRLSEQELLDASDRVQLLH-SQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 1419 KKPKIRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCEN-NEHEPLSAPTVDHAMI 1477
K K + + + S +L+R + V +L +E E L+ +
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI- 1816
Query: 1478 CHRSDDSGRYLNYSSELDIEKELGVDKL----ELSKSVKEKT---EDDKRRILERLSSDG 1530
R +ELD+E++ G + L + + VKE T E+D++ IL
Sbjct: 1817 ---QKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILR------ 1867
Query: 1531 QKLAILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVE 1590
LQDL K + K KS KR EE EE Q+S ++ +E
Sbjct: 1868 ---------LQDLVDKLQAKVKS----------YKRQAEEAEEQANTQLSRCRRVQHELE 1908
Query: 1591 EGASSLDREIPRRGSEQIGKLQFEVQNI 1618
E A D Q+ KL+ + +++
Sbjct: 1909 EAAERAD-----IAESQVNKLRAKSRDV 1931
Score = 104 bits (260), Expect = 2e-21
Identities = 183/850 (21%), Positives = 345/850 (40%), Gaps = 134/850 (15%)
Query: 39 KVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHK 98
++++ I+ +EEE ++ K+R +L + +EE ++ER + A G
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEE-------ISERLEEASGA------ 1160
Query: 99 TMPEAFPNSAYYILND--DSPCGSLGPDAESHT---SARPTHRSKKNERSSEESNGEVQT 153
SA +N ++ + D E T A KK S E ++
Sbjct: 1161 -------TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 154 LREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKES 213
L+ K++ +K L ++ + N+ + + + R ++D+ SE + + E +
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 214 LMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQ 273
+ L K + + + ES++SQ KQ LT+ L + K+
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQ-----LTKSKQALTQ-------QLEELKR 1321
Query: 274 CLEKIPMLENKIALAEENSR----MLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHH 329
+E+ +N +A A ++SR +L +Q E + L++ L++ N E Y
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKTKYE- 1380
Query: 330 CLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQR 389
+ I + E ++E ++L ++++ EK E + LEK+ Q LQ E E+L++
Sbjct: 1381 -TDAIQRTE----ELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDLMR- 1434
Query: 390 IASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYG 449
+L HT L + + L Q +QKE R+L+ E
Sbjct: 1435 ------DLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE---- 1484
Query: 450 LLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLK---KQQMEISKLKEIKEKLE 506
L + + ++ ++++ + ENK L E T + K E K K++ E+ +
Sbjct: 1485 ---LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541
Query: 507 REFHTST---------EESNVL--QRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFA 555
+ + EES +L Q E Q+K + L+ + E+++ L N A
Sbjct: 1542 SDLQVALEEVEGSLEHEESKILRVQLELSQVKSE---LDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 556 ASVRDLQNENFMLKETCKKEHSEKEALREKSK---DMNEVLMENACMEFSLLGLNDELDG 612
+++ + + S +ALR K K D+NE+ ++ + L
Sbjct: 1599 EALQSVLDAEI---------RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRT 1649
Query: 613 LRGTVKEIQ-------QFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKS 665
++G +K+ Q + + L+E+ +I+ LL +L+ + ++++ + E+
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQE 1709
Query: 666 LSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNL 725
L DA D +LL+ + +L N + L + + + ++ N ++ N
Sbjct: 1710 LLDA--------------SDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
Query: 726 EEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLG 785
EEK +K A EEL K+ H E NLE V+ LQ RL
Sbjct: 1756 EEK---AKKAITDAAMMAEEL-------KKEQDTSAH-LERMKKNLEQTVKDLQ--HRLD 1802
Query: 786 KVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTE-CEKLVEASKFSDKV-----IS 839
E EQ + QI+ L+N + ELE + V E L A K+ KV +
Sbjct: 1803 --EAEQLALKGGKKQIQK--LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQA 1858
Query: 840 ELESENLMQL 849
E + +N+++L
Sbjct: 1859 EEDRKNILRL 1868
Score = 80.1 bits (196), Expect = 5e-14
Identities = 137/764 (17%), Positives = 301/764 (38%), Gaps = 96/764 (12%)
Query: 30 LENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPEL---MKLVEEFYRAYRALAERY 86
++NL + K++ ++ E D A E K + + + VE+ + +A E+
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270
Query: 87 DHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEE 146
+ +L + ++ + +S L ++ T + ++ +R EE
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ-----QLEELKRQMEE 1325
Query: 147 SNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQ 206
+ AL + D D L QY+E E ++++ L+KA + + IQ
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKTKYETDAIQ 1385
Query: 207 ----VEILKESLMQ-LKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVV 261
+E K+ L Q L+ ++ E ++C A LE Q+ E ++L ++L R
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEEKTETANSKC----ASLEKT-KQRLQGEVEDLMRDLERSH 1440
Query: 262 VQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERD 321
T L+K +K+ LAE ++ + ++ E+E +K ++ E
Sbjct: 1441 TACAT--------LDKKQRNFDKV-LAEWKQKL-----DESQAELEAAQKESRSLSTELF 1486
Query: 322 SLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQL 381
+ Y ++++ + E ++QE L +I + + L+ +EK + ++E+ +LQ+
Sbjct: 1487 KMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV 1546
Query: 382 ---EAENLVQRIASK---------------DHELLEKHTEIER-----------LQTLMH 412
E E ++ SK D +++EK EIE+ LQ+++
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Query: 413 GE--------------HSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLEL 458
E + ++E L + +++Q+ R + +LK L L D
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALR 1666
Query: 459 SKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNV 518
S +D KE++ + N L E L++ ++ + + + + E+E +++ +
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLE-------ELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 519 LQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSE 578
L + + + + L ++++ + + + M+ E KKE
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 579 KEALREKSKDMNEVLME-----NACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSI 633
L K++ + + + + + +L G ++ L V+E++ V Q+ +
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839
Query: 634 LADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDE 693
+++ +T ++ +N L+ + + + + + ++ + E E
Sbjct: 1840 ALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE--------E 1891
Query: 694 KNNLQNERSMLIS-QLEIVEEKLSNLEKKVTNLEEKYADVEKDK 736
+ N Q R + +LE E+ E +V L K DV K
Sbjct: 1892 QANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQK 1935
Score = 72.8 bits (177), Expect = 7e-12
Identities = 97/516 (18%), Positives = 213/516 (40%), Gaps = 64/516 (12%)
Query: 127 SHTSARPTHRSKKN--------ERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLEN 178
SHT+ + ++N ++ +ES E++ ++ + ++ + Y+E ++
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498
Query: 179 LSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARL 238
L + + Q L ++ +E ++ +++ ++ +K +V + ++
Sbjct: 1499 LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
Query: 239 ESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQ 298
ES + + +E +K EL R V++KD + Q K+ ++ + AE SR ND
Sbjct: 1559 ESKILRVQ-LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR--NDA 1615
Query: 299 IERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQE---NAEQLKNKI 355
+ + L + ++ ++ H ++++ LH+ + + E LK
Sbjct: 1616 LRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSNEDLK--- 1672
Query: 356 EKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEH 415
E+L I E+ G+L + + +++ E + + ELL+ ++ L+H ++
Sbjct: 1673 ----EQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQ----LLHSQN 1724
Query: 416 SNFIQIESALQA----LQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEM---- 467
++ I + L+A Q S +E RN + K + D + ++ K+E
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAIT---DAAMMAEELKKEQDTSA 1781
Query: 468 ------QGIVEENKTL-HELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEES---- 516
+ + + K L H L+ + +LK + +I KL+ +LE E +
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL 1841
Query: 517 -------NVLQRETHQIKDD------IQHLNERYQAMLE----QLQSLGLNPNSFAASVR 559
++ T+Q ++D +Q L ++ QA ++ Q + N+ + R
Sbjct: 1842 KGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR 1901
Query: 560 DLQNENFMLKETCKKEHSEKEALREKSKDMNEVLME 595
+Q+E E S+ LR KS+D+ ME
Sbjct: 1902 RVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
>MYHA_RAT (Q9JLT0) Myosin heavy chain, nonmuscle type B (Cellular
myosin heavy chain, type B) (Nonmuscle myosin heavy
chain-B) (NMMHC-B)
Length = 1976
Score = 145 bits (365), Expect = 1e-33
Identities = 240/1112 (21%), Positives = 455/1112 (40%), Gaps = 190/1112 (17%)
Query: 235 IARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRM 294
+ R E L KD E +K++ T+V + + + +++Q +LE K LAE+
Sbjct: 847 VTRQEEELQAKDE-ELLKVKEKQTKVEGELEEMERKHQQ------LLEEKNILAEQLQA- 898
Query: 295 LNDQIERTEL--EVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLK 352
TEL E E +R LA +E + + H LE S++E E +E + L+
Sbjct: 899 ------ETELFAEAEEMRARLAAKKQELEEIL----HDLE--SRVEGE----EERNQILQ 942
Query: 353 NKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMH 412
N+ +K ++ E+ E + Q LQLE +I + E+L L+
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVL-----------LLE 991
Query: 413 GEHSNFIQ----IESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQ 468
++S FI+ +E + ++ +++ +NLA +++ DLE
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE----------- 1040
Query: 469 GIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKD 528
LKK++ +L++ K KL+ E ++ LQ + ++K
Sbjct: 1041 -----------------ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKV 1083
Query: 529 DIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKD 588
+ E Q L + L+ N+ R+LQ + L+E + E + + ++ +D
Sbjct: 1084 QLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 589 MNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQII 648
++E L E L D LD + + Q + E K L DE +Q+Q +
Sbjct: 1144 LSEEL------EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDM 1197
Query: 649 TE----SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSML 704
+ +++++ E ++ ++ + +GL + +L K+L K +++R L
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 705 ISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL----------FASILVQK 754
+Q++ + K+S ++ L EK ++ + ++ +EE A + Q
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQL 1317
Query: 755 ENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELE 814
++ + NL + +R L+EE+ + + E+E + N + ++ LQ+ + + +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 815 LKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLH-RIRKFKMDIHKVCGVL 873
K L E L EA K K++ ++E+ L Q +EE+ L + ++ K K
Sbjct: 1378 KKVDDDLGTIEGLEEAKK---KLLKDVEA--LSQRLEEKVLAYDKLEKTK---------- 1422
Query: 874 QIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSE 933
N +++E ++ LD + S+L K Q++ QLL E + + +
Sbjct: 1423 ---------NRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDR 1473
Query: 934 GEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV-------------VNGV 980
E EK+T E+ + + K E +N+QLR ++ V+ +
Sbjct: 1474 AEAEAREKETKALSLARALEEAL---EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 981 EKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENS 1040
EK R AL+ ++ E+R + ++E D K L N+ +K A+ E
Sbjct: 1531 EKSKR------ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK-----AQFERD 1579
Query: 1041 VMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEA 1100
+ D +N +KR L + + L D ++ + + + E
Sbjct: 1580 LQTRD---------------EQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEI 1624
Query: 1101 ENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELK-------MEQEESTKIKEN 1153
+ L IE +K E+ K+L+ + ++ R +EE + + +ES K ++
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 1154 LDRQILEQSENCMNHKKEIEHLNEANETLQFEM-------KTLLHEVE---------QHR 1197
L+ +IL+ E + ++ H + + L E+ LL E +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 1198 VREEALNLELLNKE-----NEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKIL 1252
+ EE N+ELLN + E AA Q S LE + EL K+
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELK--AKLQ 1802
Query: 1253 DDESSAKSLENEHMREIISLLESEIGGLKEQL 1284
+ E + KS + IS LE++IG L+EQL
Sbjct: 1803 ELEGAVKS----KFKATISALEAKIGQLEEQL 1830
Score = 138 bits (347), Expect = 1e-31
Identities = 236/1149 (20%), Positives = 463/1149 (39%), Gaps = 171/1149 (14%)
Query: 202 EAEIQV---EILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELT 258
E E+Q E+LK Q K + + LE + R L ++ NI A+ L+ E T
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGE---------LEEMERKHQQLLEEKNILAEQLQAE-T 900
Query: 259 RVVVQKDTV---LLQYKQCLEKIPM-LENKIALAEENSRMLNDQIERTELEVETLRKNLA 314
+ + + + L KQ LE+I LE+++ EE +++L ++ ++ + ++ L + L
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEGEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 315 EMNEERDSLSVLYHHCLEKISKMENEILHVQE---------------------------- 346
E R L + KI KME E+L +++
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 347 ---NAEQLKNK----IEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLE 399
N +++NK I E+L+ EK R LEK+ + L E +L +IA ++ E
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDE 1080
Query: 400 KHTEI----ERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD 455
++ E LQ + + +AL+ ++L +Q + Q + E
Sbjct: 1081 LKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESE----KASRNK 1136
Query: 456 LELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEE 515
E K+D EE++ + E + + + K++ E+++LK+ E + ++
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQD 1196
Query: 516 SNVLQRETHQIKDDIQHLNE--RYQAMLEQ-LQSLGLNPNSFAASVRDLQNENFMLKETC 572
+ QR +++ + L + R++A LE+ Q L + A V+ LQ +
Sbjct: 1197 --MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 573 KKEHSEKEALREKSKDMNEVLME---------NACMEFSLLGLNDELDGLR------GTV 617
KK ++ + L K + + + +E N S L E G++ G
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLE 1314
Query: 618 KEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLR 677
++Q ++LQEE +K L S+++ + E + E E+ + +E + L
Sbjct: 1315 SQLQDTQELLQEE----TRQKLNLSSRIRQLEEEKNSLQEQQE--EEEEARKNLEKQVLA 1368
Query: 678 IKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKE 737
++S L D K ++D+ ++ L+ VE LE+KV Y +EK K
Sbjct: 1369 LQS-QLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVL----AYDKLEKTKN 1423
Query: 738 SAVNQVEELFASILVQKENHSN---HKHSSEARLANLENIVRVLQEEQRLGKVEFEQELD 794
++++L + Q++ SN + + LA + I EE+ + E ++
Sbjct: 1424 RLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKET 1483
Query: 795 RVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELES----------- 843
+ ++ + EE E +N L + E L+ + K + ELE
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 844 -ENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESL 902
++ +E+E K +++++ Q + D +E +E+ + +L ++ L
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL--LLKQVREL 1601
Query: 903 ESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDK 962
E+ L +++ + + L+ +++ E + V ++ ++ Q KD
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ----MKDY 1657
Query: 963 VELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLC 1022
LEE R R E+ + S+ L +L+AE+++L++ + E++ L
Sbjct: 1658 QRELEEARASRDEI---FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 1023 RNVSDLKDAKSSAEDENSVMFHDVLAL--------SNLNLVYEIF---------FTENMV 1065
+++ KS+ DE + + L SN+ L+ + F +
Sbjct: 1715 DEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELA 1774
Query: 1066 EKRALCEHLGN----LSHLNNDLNQEF----GVLRKNFEVK----EAENVYLNESIERMD 1113
+R+ + N L N +L + G ++ F+ EA+ L E +E+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 1114 KELLEMDKRLKAAETSNAEF-------SRHIEELKMEQEESTKIKENLDRQILEQSE--- 1163
KE +K ++ E E RH ++ K + E++ + L RQ+ E E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 1164 --NCMNHK--KEIEHLNEANETLQFEMKTLLHEVE-------------QHRVREEALNLE 1206
N K +E++ EANE L E+ TL + + + ++ E +LE
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLE 1954
Query: 1207 LLNKENEFK 1215
L + + E K
Sbjct: 1955 LSDDDTESK 1963
Score = 120 bits (300), Expect = 4e-26
Identities = 185/938 (19%), Positives = 387/938 (40%), Gaps = 103/938 (10%)
Query: 141 ERSSEESNGEVQTLREALAKMQSDKDALFLQY---QESLENLSKMETDLNKAQNNARGL- 196
E++ + +GE L++ +A++Q+ D L +Q +E L+ D +NNA +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVA 1113
Query: 197 -DDRASEAEIQVEILKESLMQLKADK---DAGEVL------YNQCLETIARLESMLSQKD 246
+ +A AE+Q + E + KA+K D E L L+T A + + ++++
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 247 NI----------EAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLN 296
E KN + ++ + + T L + + LE+ + + E+N + L
Sbjct: 1174 QEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL---EKNKQGLE 1230
Query: 297 DQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIE 356
+ EV+ L++ AE +R L K+S+ + + + E A +L+N+++
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELD 1290
Query: 357 KEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHS 416
+ LE +EK K L+ + ++ ELL++ T ++L S
Sbjct: 1291 NVSTLLEEAEKKGMKFAKDAAGLESQLQD--------TQELLQEETR-QKLNL-----SS 1336
Query: 417 NFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKT 476
Q+E +LQ+ + ++ ++NL ++ L D + D ++G+ E K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKK 1396
Query: 477 LHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNER 536
L + + ++ L+++ + KL++ K +L++E T + + QI +++ ++
Sbjct: 1397 LLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLD----HQRQIVSNLEKKQKK 1452
Query: 537 YQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMEN 596
+ +L + + + ++ A RD KET K S AL E + E +N
Sbjct: 1453 FDQLLAEEKGI----SARYAEERDRAEAEAREKET--KALSLARALEEALEAKEEFERQN 1506
Query: 597 ACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKIL 656
+ + L D + V E L++ K L + + +QL+ + + +Q
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHE-------LEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 657 ENNTVLEKSLSDAKIEFE-GLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKL 715
+ LE ++ K +FE L+ + E+ +LL + L+ E Q +
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASK 1619
Query: 716 SNLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIV 775
+E + +LE + K ++ + Q+ +L Q + + EAR + E
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKL------QAQMKDYQRELEEARASRDEIFA 1673
Query: 776 RVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSD 835
+ + E++L +E E ++ Q E+ + E E + +D
Sbjct: 1674 QSKESEKKLKSLEAE-----ILQLQEELASSERARRHAE-------------QERDELAD 1715
Query: 836 KVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRI 895
++ + ++ + L E+ L RI + + ++ + +++ +D +K + + +
Sbjct: 1716 EIANSASGKSAL-LDEKRRLEARIAQLEEELEEEQSNMELLND-----RFRKTTLQVDTL 1769
Query: 896 LDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQ-SEGEKLKLEKKTVEQEFENMREQ 954
++ + S+ KS QQL +N L LQ+ + + K K +E + + EQ
Sbjct: 1770 NTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ 1829
Query: 955 NVILQKDKVELLEENRQLR------IEVVNGVEKENRS----KSTLAALQAEMIELRQTN 1004
L+++ E N+ +R E+ VE E R K + A M +L++
Sbjct: 1830 ---LEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 1886
Query: 1005 QVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVM 1042
+ +EE + + L R + D +A E S +
Sbjct: 1887 EEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Score = 91.7 bits (226), Expect = 2e-17
Identities = 180/918 (19%), Positives = 387/918 (41%), Gaps = 103/918 (11%)
Query: 781 EQRLGKVEFEQELDRVVNAQI--EMFILQNCIEELELK--NFVLLTE--CEKLVEASKFS 834
E+ + +E + L R+ ++I +L + EE +LK + ++ + C + F+
Sbjct: 748 ERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFA 807
Query: 835 DKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISR 894
K +L + ++Q +L R ++ KV +LQ+ + E++ ++ + +
Sbjct: 808 KKQ-QQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ---EEELQAKDEELLK 863
Query: 895 ILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQ---SEGEKLKLEKKTVEQEFENM 951
+ +K +E L + + ++QQLL E ++L LQ +E E+++ +QE E +
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 952 -----------REQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIEL 1000
E+N ILQ +K ++ + L ++ + + +A++ ++
Sbjct: 924 LHDLESRVEGEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 1001 RQTNQVFQEENGKMLDEKNSLCRNV----SDLKDAKSSAEDENSVMFHDVLALSNLN--L 1054
+ + +++N K + EK + + S L + + A++ + + +S+L L
Sbjct: 984 EEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 1055 VYEIFFTENMVE-KRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMD 1113
E + + + KR L +L +L + L+ KE E L ++ R D
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEE---LQGALARGD 1100
Query: 1114 KELLEMDKRLKAA---ETSNAEFSRHIEELKMEQEESTKIKENLDRQI------LEQSEN 1164
E L + LK A + AE E K + ++ K K +L ++ LE + +
Sbjct: 1101 DETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 1165 CMNHKKEI-----EHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWEN 1219
++E+ + + E + L+ E K +++ R R A LE L+++ E
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRH-ATALEELSEQLE------ 1213
Query: 1220 EAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGG 1279
+A F +L+ + LE+ EL K+L + E+EH R+ + E+
Sbjct: 1214 QAKRFKANLEKNK---QGLETDNKELACEVKVLQQVKA----ESEHKRKKLDAQVQELHA 1266
Query: 1280 -LKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSAR 1338
+ E V L + N L+++S L + A+ +E+ L Q +
Sbjct: 1267 KVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQL-----QDTQ 1321
Query: 1339 ENEIVLIPDGVSDLLTLQTRIRAVEK----IMMEELKRRVKQKSLTTESTPYSSLEIATY 1394
E L+ + L L +RIR +E+ + ++ + +K+L + S T
Sbjct: 1322 E----LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 1395 PKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIP-LDRNVDDQNSKY--LKREHRRT 1451
KV++ IE +EE +KK L+KD+ L + ++++ Y L++ R
Sbjct: 1378 KKVDDDLGTIEGLEEA-------KKK-----LLKDVEALSQRLEEKVLAYDKLEKTKNRL 1425
Query: 1452 NDHVLELCENNEHEPLSAPTVDHA------MICHRSDDSGRYLNYSSELDIE-KELGVDK 1504
+ +L + +H+ ++ ++ S RY + E +E
Sbjct: 1426 QQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKA 1485
Query: 1505 LELSKSVKEKTE--DDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYE 1562
L L+++++E E ++ R ++L +D + L K D+ K +KSK+ + + E
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK---DDVGKNVHELEKSKRALEQQVE 1542
Query: 1563 TVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYIL 1622
++ +EE+E+ + ++ N++ + +R++ R + K + ++ ++ +
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELE 1602
Query: 1623 LKLAEENNNKVKNRISRK 1640
+L +E + S+K
Sbjct: 1603 AELEDERKQRALAVASKK 1620
Score = 83.2 bits (204), Expect = 6e-15
Identities = 101/513 (19%), Positives = 213/513 (40%), Gaps = 40/513 (7%)
Query: 33 LTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGE 92
+++++ K K +L+ EE AR AE + E + + RAL E + A E
Sbjct: 1443 VSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALE-AKEE 1501
Query: 93 LRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSS-EESNGEV 151
+K + + +++ G + E S R + + R+ EE E+
Sbjct: 1502 FERQNKQLRADMED----LMSSKDDVGKNVHELEK--SKRALEQQVEEMRTQLEELEDEL 1555
Query: 152 QTLREALAKMQSDKDALFLQYQESLE-----NLSKMETDLNKAQNNARGLDDRASEAEIQ 206
Q +A +++ + A+ Q++ L+ N K L + + L+D + +
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALA 1615
Query: 207 VEILKE---SLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQ 263
V K+ L L+A +A ++ ++ + +L++ + K+ ++EL
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM--------KDYQRELEEARAS 1667
Query: 264 KDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSL 323
+D + Q K+ +K+ LE +I +E E E + L +A + +L
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSAL 1727
Query: 324 SVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEA 383
+I+++E E+ Q N E L ++ K +++ + Q ++
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQ----KS 1783
Query: 384 ENLVQRIASKDHELLEKHTEIE-----RLQTLMHGEHSNFIQIESALQALQKLYSQSQKE 438
+N Q++ ++ EL K E+E + + + + Q+E L+ K + + K
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Query: 439 QRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKL 498
R +LK + ++D +KE+M+ + N + +L R L++ + E ++
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQME---KANARMKQLK----RQLEEAEEEATRA 1896
Query: 499 KEIKEKLEREFHTSTEESNVLQRETHQIKDDIQ 531
+ KL+RE +TE + L RE +K+ ++
Sbjct: 1897 NASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
>CENF_HUMAN (P49454) CENP-F kinetochore protein (Centromere protein F)
(Mitosin) (AH antigen)
Length = 3210
Score = 143 bits (361), Expect = 3e-33
Identities = 280/1383 (20%), Positives = 568/1383 (40%), Gaps = 244/1383 (17%)
Query: 127 SHTSARPTHRSKKNERSSEESNGEVQTL--REALAKMQSDKDALFLQYQESLENLSKMET 184
SH S+ + + S+ +GE++ R L + D ++ F S L +++
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGELEVTPSRSTLQIGKRDANSSFFGNSSSPHLLDQLKA 285
Query: 185 DLNKAQNNARGLDDRAS--EAEIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESML 242
+ +N L+ R E E++ ++ K +QL+ +K A++E L
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEK--------------AKVE--L 329
Query: 243 SQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERT 302
+K+ + K + EL R Q D +Y +K+ L ++ +N+ +E+
Sbjct: 330 IEKEKVLNK-CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQK 388
Query: 303 ELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKL 362
E E ++ E++ ++ S L C++ +++ E+ + A+ + N ++ E +KL
Sbjct: 389 IKEKE--KEFQEELSRQQRSFQTLDQECIQMKARLTQEL----QQAKNMHNVLQAELDKL 442
Query: 363 -EISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQI 421
+ ++ LE+ Q L AE Q K++EL E+++ L+ HS
Sbjct: 443 TSVKQQLENNLEEFKQKL-CRAEQAFQASQIKENELRRSMEEMKKENNLLKS-HSE---- 496
Query: 422 ESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELN 481
Q +E +L ELK +K Q+F EEM+ +T+ +
Sbjct: 497 ------------QKAREVCHLEAELKN----IKQCLNQSQNFAEEMKAKNTSQETMLR-D 539
Query: 482 FSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAML 541
+ ++ + + KLK LE++ S + + Q+ D + + +A+L
Sbjct: 540 LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
Query: 542 EQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEF 601
L+ LK+ +E E++ L K NE L+
Sbjct: 600 SALE----------------------LKKKEYEELKEEKTLFSCWKSENEKLLTQ----- 632
Query: 602 SLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTV 661
+ E + L+ + ++ C Q+ KS +E+ + L++ E++ + N
Sbjct: 633 ----MESEKENLQSKINHLET-CLKTQQIKSHEYNER---VRTLEMDRENLSVEIRN--- 681
Query: 662 LEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNER-----SMLISQLEIVEEKLS 716
L L +E E ++ +L+ + +D+K+ + E S L Q+E +E KL
Sbjct: 682 LHNVLDSKSVEVETQKLAYMELQQKAEF-SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 717 NLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVR 776
L ++ + + Y D+ + ES + ++ AS LV E+H + + + A +
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS-LVTNEDHQRSLLAFDQQPAMHHSFAN 799
Query: 777 VLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELK-------NFVLLTECEKLVE 829
++ E+ + E L+ + + ILQN ++ LE N L +CE+LV+
Sbjct: 800 IIGEQGSMPSERSECRLEADQSPK-NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
Query: 830 ASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGD------N 883
+ E+E ENLM+ + +H+ F + + LQ D+ + +
Sbjct: 859 -------IKGEIE-ENLMKAEQ----MHQ--SFVAETSQRISKLQEDTSAHQNVVAETLS 904
Query: 884 EIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKT 943
++ +E + + DK+E+ Q E Q+L N +L SL++ Q E L LEKK
Sbjct: 905 ALENKEKELQLLNDKVET-------EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE 957
Query: 944 VE--------------QEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKST 989
+ QE ++E N L ++K+ L++++ N +++ +S S
Sbjct: 958 MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF----ANYIDEREKSISE 1013
Query: 990 LA--ALQAEMI-------------ELRQTNQVFQEENGK---MLDEKNSLCRN----VSD 1027
L+ Q ++I +L Q + QE+N K +L+E SLC N +
Sbjct: 1014 LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073
Query: 1028 LKDAKSSAEDENSVMFHDVLALS---NLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDL 1084
LK+A + E F LA + N NL+ E+ V++ E N NN
Sbjct: 1074 LKEAFAKEHQE----FLTKLAFAEERNQNLMLEL----ETVQQALRSEMTDN---QNNSK 1122
Query: 1085 NQEFGVLRKNFEVKEAENVYLNE--SIERMDKELLEMDKRLKAAETSNAEFSRHIEELKM 1142
++ G+ ++ +KE +N E + + +++L+++ K + +E R+ + +
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
Query: 1143 EQEESTKIKENLDRQILE-----------QSENCMNHKK-EIEHLNEANETLQFEMKTLL 1190
+ K +D ++ E Q E + +K+ +++ + E LQ E++T+
Sbjct: 1183 SERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
Query: 1191 HEVEQHRVRE------EALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSE 1244
++E +++ L ++ E ++ +E + +D L +K++E
Sbjct: 1243 GDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
Query: 1245 LTGVCKI-----------LDDESSAKSLENEHMREIISLLESEI---------------- 1277
L +C+I L+D S M E + L +E+
Sbjct: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
Query: 1278 ----GGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLR--- 1330
G EQ + P+ + ++ NS EH++L + +K + +++ +
Sbjct: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILH 1422
Query: 1331 -KHSHQSARENEIVLIPDGV-SDLLTLQTRIRAVEKIMMEELKRRVKQ---KSLTTESTP 1385
+H S++ +E+ D + ++ L L T +R + +++E++ +++ SL++ P
Sbjct: 1423 DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP 1482
Query: 1386 YSS 1388
SS
Sbjct: 1483 DSS 1485
Score = 141 bits (355), Expect = 2e-32
Identities = 283/1248 (22%), Positives = 513/1248 (40%), Gaps = 197/1248 (15%)
Query: 117 PCGSLGPDAESHT-SARPTHRSKKNERSS---EESNGEVQTLREALAKMQSDKDALFLQY 172
P LG + H R S +N R E+ + +V++L + ++ S +Q
Sbjct: 1855 PMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQL 1914
Query: 173 QESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESL---------MQLKADKDA 223
+E ++E + + + L ++ + L + + +++ ADK +
Sbjct: 1915 MTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS 1974
Query: 224 GEVLYNQC-----------LETIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYK 272
E + + L+ L + S+K +IE + L E VVQ + K
Sbjct: 1975 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE------K 2028
Query: 273 QCLEK--------IPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLS 324
CLEK I LE ++++ L +++ + L + +M E+ L
Sbjct: 2029 LCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELE 2088
Query: 325 VLYHHCLEKISKMENEILHVQENAEQLKNKI-EKEAEKLEISEKHRGMLEKSNQNLQLEA 383
CL I E E+ E + L + + E +K + EK + LEK +Q L L
Sbjct: 2089 SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS-LEKDSQALSLTK 2147
Query: 384 ENLVQRIA--SKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRN 441
L +IA +K+ ELL K +E +LQ S+S E+ N
Sbjct: 2148 CELENQIAQLNKEKELLVKESE-----------------------SLQARLSESDYEKLN 2184
Query: 442 LALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEI 501
++ L+ L+ K +F + EE +H+L R ++K ++ I E
Sbjct: 2185 VSKALEAALV-------EKGEFALRLSSTQEE---VHQLR----RGIEKLRVRI----EA 2226
Query: 502 KEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDL 561
EK ++ H + E+ +RE +KD +++L Q E + + L+ + A V L
Sbjct: 2227 DEK--KQLHIA-EKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2283
Query: 562 QNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEI- 620
+ + + + K + LR + +++ + + E G ELD L + K +
Sbjct: 2284 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ-------GQLSELDKLLSSFKSLL 2336
Query: 621 ----QQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVL---EKSLSDAKIEF 673
Q Q+ +E K+ + L +QL+ + E++ + + ++ E+SL E
Sbjct: 2337 EEKEQAEIQIKEESKTAV----EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2392
Query: 674 EGLRIKSGDLEDCCKLLNDEKNNL---------QNERSMLISQLEIVEEKL----SNLEK 720
LR L +L DEK L ++ +L ++E +E +L +N E
Sbjct: 2393 HQLRNSIEKLR--ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2450
Query: 721 KVTNLEEKYADVEKDKESAVNQVEEL------FASILVQKENHSNHKHSSEARLANLE-- 772
E +VE K + L +I +KE+ +N + R++ LE
Sbjct: 2451 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEII 2510
Query: 773 --NIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECE--KLV 828
+ +LQE+++ KV+ +++ + M +LQ ++EL + L + E K
Sbjct: 2511 NSSFENILQEKEQ-EKVQMKEK------SSTAMEMLQTQLKELNERVAALHNDQEACKAK 2563
Query: 829 EASKFSDKVISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKE 888
E + S ELE L+Q ++E + + + V G++Q DG E K E
Sbjct: 2564 EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ-----SSVNGLIQEVEDGKQKLEKKDE 2618
Query: 889 EIPISRILDKIESLESSLVK-SQEENQ-QLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQ 946
E ISR+ ++I+ E + K SQ E + QL E ++ L +L ++LE+K
Sbjct: 2619 E--ISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL--------TVELEQKIQVL 2668
Query: 947 EFENMREQNV--ILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTN 1004
+ +N Q+ +LQ L E +++ ++ VEK N+ + LQ EM E+ Q
Sbjct: 2669 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2728
Query: 1005 QVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENM 1064
QEE + EKN L + L + S++D+ L L L EN
Sbjct: 2729 AELQEE---LSGEKNRLAGELQLLLEEIKSSKDQ----------LKELTL-------ENS 2768
Query: 1065 VEKRAL-CEHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRL 1123
K++L C H + + + E ++ L ++ ++ + E+ ++L
Sbjct: 2769 ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2828
Query: 1124 KAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQ 1183
+ E + I+ LK +EE + + + E + M++ K + L + NE Q
Sbjct: 2829 TSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ 2888
Query: 1184 FEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVS 1243
+MK L+ +Q + EE E+L KE L + +AA Q ++++KV
Sbjct: 2889 GKMKLLIKSCKQ--LEEEK---EILQKE----LSQLQAA------QEKQKTGTVMDTKVD 2933
Query: 1244 ELTGVCKILDDESSAKSLE-NEHMREIISLLES--EIGGLKEQLSAYV 1288
ELT K L + K+ E +E++ + SLL S ++ KE L V
Sbjct: 2934 ELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2981
Score = 107 bits (268), Expect = 2e-22
Identities = 343/1739 (19%), Positives = 672/1739 (37%), Gaps = 279/1739 (16%)
Query: 42 SMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMP 101
+M KL E E +AE Y + EL E A R +AE + E++
Sbjct: 1296 TMNKLNELEKICEILQAEKY-ELVTELNDSRSECITATRKMAEEVGKLLNEVK------- 1347
Query: 102 EAFPNSAYYILNDDS-----------PCGSLG--PDAESHTSARPTHRSKKNER---SSE 145
ILNDDS P G G P+ + S P S E S +
Sbjct: 1348 ---------ILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK 1398
Query: 146 ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMET--DLNKAQNNARGLDDRASEA 203
E L+E +QS+ L Q+ + +S+++T D KA+N + R
Sbjct: 1399 EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLR---- 1454
Query: 204 EIQVEILKESLMQLKADKDAGEVLYNQCLETIARLESM---------LSQKDNIEA-KNL 253
Q +++KE MQL ++ L + C+ + L S+ L Q ++ NL
Sbjct: 1455 NFQGDLVKE--MQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNL 1512
Query: 254 KQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVE-----T 308
+ ++ D V Q EN + L+ D ++ +L +E +
Sbjct: 1513 EGAVSANQCSVDEVFCSSLQTYVDSLKAEN-LVLSTNLRNFQGDLVKEMQLGLEEGLVPS 1571
Query: 309 LRKNLAEMNEERDSL--SVLYHHCLEK------ISKMENEILHVQENAEQL-------KN 353
L + + SL S Y LE+ +S +E + Q + +++ +N
Sbjct: 1572 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGVVSANQCSVDEVFCSSLQEEN 1631
Query: 354 KIEKEA--------EKLE-ISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEI 404
KE E+LE + E +R LEK + ++ + + I + L + E+
Sbjct: 1632 LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL 1691
Query: 405 ERLQTLMHGEHSNFIQ-IESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQ-- 461
+ L+ E+ + Q + S ++ + +K+ L+LEL+ L L+ L+LS +
Sbjct: 1692 DCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1751
Query: 462 ---DFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNV 518
D ++ +QG E E +T K + K+ ++ L + TE V
Sbjct: 1752 LGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAV 1811
Query: 519 L--------QRETHQIKDDIQHLNERYQAMLEQLQSLGLN---PNSFAASVRDLQNENFM 567
Q + + + + +L G N P F + D+ N
Sbjct: 1812 KPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1871
Query: 568 LKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVL 627
+KET + + ++ + + +L E ++ L +L E+++ L
Sbjct: 1872 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGEL 1931
Query: 628 QEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSG------ 681
++E S L+++ Q + + ++ N+ LE + E G +
Sbjct: 1932 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1991
Query: 682 ---DLEDCCKLLNDEKNNLQNERSMLISQLEIVE-EKL------SNLEKKVTNLEEKYAD 731
D+E+ + EK ++++E L + LE+V+ EKL N +K + LEE+ +
Sbjct: 1992 RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV 2051
Query: 732 VEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQ 791
V ++ +++ + + K ++ ++ + +Q + +V+ +
Sbjct: 2052 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE--AEVKEKT 2109
Query: 792 ELDRVVNAQIEMFI-----LQNCIEELELKNFVL-LTECEKLVEASKFSDKVISELESEN 845
EL + +++ + + LQ ++ LE + L LT+CE + I++L E
Sbjct: 2110 ELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL--------ENQIAQLNKEK 2161
Query: 846 LMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDK--IESLE 903
+ + E E L R+ +E E++ +S+ L+ +E E
Sbjct: 2162 ELLVKESESLQARL-----------------------SESDYEKLNVSKALEAALVEKGE 2198
Query: 904 SSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKV 963
+L S + + + + ++ E ++L + +K E+E EN KDKV
Sbjct: 2199 FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS------LKDKV 2252
Query: 964 ELLEENRQLRIEVVNGV--EKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSL 1021
E LE Q+ E V + EN SK+ + L+ ++ E+ ++ +VF+ + + EK +L
Sbjct: 2253 ENLERELQMSEENQELVILDAEN-SKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2311
Query: 1022 CRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLN 1081
+ + + + S D L S +L+ E E +++ E + L
Sbjct: 2312 TKQIQEKQGQLSEL---------DKLLSSFKSLLEEKEQAEIQIKE----ESKTAVEMLQ 2358
Query: 1082 NDLNQEFGVLRKNFEVKEAENVYLNESIERM--DKELLEMDKRLKAAETSNAEFSRHIEE 1139
N L + LNE++ + D+E++ KA E S IEE
Sbjct: 2359 NQLKE------------------LNEAVAALCGDQEIM------KATEQS---LDPPIEE 2391
Query: 1140 LKMEQEESTKIKENLDRQILEQSENC-MNHKKEIEHLNEANETLQFEMKTLLHEVEQHRV 1198
+ K++ L+ E+ + C + KE EH + L+ ++ L E+E R
Sbjct: 2392 EHQLRNSIEKLRARLEAD--EKKQLCVLQQLKESEH---HADLLKGRVENLERELEIART 2446
Query: 1199 REEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSA 1258
+E LE N + E + + + L+ + + + S+ +LT + + S
Sbjct: 2447 NQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISE 2506
Query: 1259 KSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFN------------------- 1299
+ N I+ E E +KE+ S + ++ + ++ N
Sbjct: 2507 LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2566
Query: 1300 --------SLEHISLLW----TKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPD 1347
LE LL K N +V + ++ E K + ++ EI + +
Sbjct: 2567 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-KDEEISRLKN 2625
Query: 1348 GVSDLLTLQTRIRAVE---------KIMMEELKRRVKQKSLTTESTPYS---SLEI--AT 1393
+ D L +++ VE + + L ++QK +S S +LE+ ++
Sbjct: 2626 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2685
Query: 1394 YPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSK------YLKRE 1447
Y +EN E+EL + D+ S+ +K ++ K+ L R + + K L E
Sbjct: 2686 YKNLEN---ELELTK---MDKMSFVEKVN-KMTAKETELQREMHEMAQKTAELQEELSGE 2738
Query: 1448 HRRTNDHVLELCE--NNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKL 1505
R + L E + + L T++++ + +S D E + +E+ +L
Sbjct: 2739 KNRLAGELQLLLEEIKSSKDQLKELTLENSEL-KKSLDCMHKDQVEKEGKVREEIAEYQL 2797
Query: 1506 ELSKSVKEKTE---DDKRRILERLSSDGQKLAILKMALQDLKKKTETKKKSKQGNDIEYE 1562
L ++ K+ D ++ + + +KL + L K + + K SK+ + +
Sbjct: 2798 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2857
Query: 1563 TVKRHIEEVEEAVMQQVSINDQMAKNVE--EGASSLDREIPRRGSEQIGKLQFEVQNIQ 1619
+ +EE+++ M + +Q+ K E +G L + ++ E+ LQ E+ +Q
Sbjct: 2858 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2916
Score = 104 bits (260), Expect = 2e-21
Identities = 253/1282 (19%), Positives = 520/1282 (39%), Gaps = 150/1282 (11%)
Query: 206 QVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKD 265
+++ L+ L +LK +K + + LE + ++ + + E NLK+E R++ +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDS-LEAAPQKQTQKVENEKTEGTNLKRENQRLMEICE 77
Query: 266 TVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSV 325
++ ++ ++ + E+++ E QIE+ E E++ + L + S V
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 326 LYHHCL--EKI--SKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQL 381
+ C +KI + + + E LK K KE E+ R LE + LQ
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE-------RKRLEAEVKALQA 190
Query: 382 EAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRN 441
+ + A+ +H + +H + + + + + S +++ +S S
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGE- 249
Query: 442 LALELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEI-SKLKE 500
LE+ L++ K+D G + + H L+ LK Q E+ +K+ E
Sbjct: 250 --LEVTPSR---STLQIGKRDANSSFFG---NSSSPHLLD-----QLKAQNQELRNKINE 296
Query: 501 IKEKL---EREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAAS 557
++ +L E+E + LQ + + K ++ + ++L + +
Sbjct: 297 LELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356
Query: 558 VRDLQNENFMLKE--TCKKEHSE------KEALREKSKDMNEVLMENACMEFSLLGLNDE 609
L+ + L E +C+++++E ++ ++EK K+ E L + S L+ E
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQ---QRSFQTLDQE 413
Query: 610 LDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDA 669
++ + Q LQ+ K++ + L ++L +T Q++ N ++ L A
Sbjct: 414 CIQMKA------RLTQELQQAKNM----HNVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
Query: 670 KIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKY 729
+ F+ +IK +L + + E N L++ ++ +E +L N+ K+ N + +
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNI-KQCLNQSQNF 522
Query: 730 ADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEF 789
A+ K K ++ + + Q+EN S + +A+LE Q+ + +
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQEN-SLTLEKLKLAVADLEKQRDCSQDLLKKREHHI 581
Query: 790 EQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKF-SDKVISELESE--NL 846
EQ D++ + E L + +E L+ K + L E + L K ++K+++++ESE NL
Sbjct: 582 EQLNDKLSKTEKESKALLSALE-LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL 640
Query: 847 M------------QLIEEEFLLHRIRKFKMD-------IHKVCGVLQIDSDGGGDNEIKK 887
Q I+ R+R +MD I + VL S E++
Sbjct: 641 QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV-----EVET 695
Query: 888 EEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLE------- 940
+++ + K E + K Q+E + + ++ S L G ++ + + + L E
Sbjct: 696 QKLAYMELQQKAEFSDQ---KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
Query: 941 KKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIEL 1000
+ + E+E++R+ ++ KD + E+ Q + + + S + + Q M
Sbjct: 753 YQDLHAEYESLRD--LLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 1001 RQTNQVFQEENGKMLDEKNSLCRN-VSDLKDAKSSAEDENSVMFHDVLALSNLN-LVYEI 1058
R ++ +++ K +++ +N V L+ + S + NS + L + + E
Sbjct: 811 RSECRLEADQSPK----NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN 866
Query: 1059 FFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNF---EVKEAENVYLNESIERMDKE 1115
+ + + E +S L D + V+ + E KE E LN+ +E E
Sbjct: 867 LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
Query: 1116 LLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHL 1175
+ E+ K E S E E L +E++E + I +K+EIE L
Sbjct: 927 IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI--------------ISLNKREIEEL 972
Query: 1176 NEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDL--QMSSI 1233
+ N TL+ E+ L++ + + L+ K F + +E +L Q
Sbjct: 973 TQENGTLK-EINASLNQEK----------MNLIQKSESFANYIDEREKSISELSDQYKQE 1021
Query: 1234 CLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSS 1293
L LL+ + E + L + A +N + +++ S K +L
Sbjct: 1022 KLILLQ-RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE-------Q 1073
Query: 1294 LKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRK-HSHQSARENEIVLIPDGVS-D 1351
LKE F + EH L TK + +ET + S + +N G+ +
Sbjct: 1074 LKEAF-AKEHQEFL-TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE 1131
Query: 1352 LLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENV 1411
++TL+ ++K + + L+ ++ + T + + + P + N KE E
Sbjct: 1132 IMTLKEEQNKMQKEVNDLLQEN--EQLMKVMKTKHECQNLESEP-IRNSVKERES----- 1183
Query: 1412 FDRNSWRKKPKIRLLMKDIPLD 1433
+RN KP++ L +K+I LD
Sbjct: 1184 -ERNQCNFKPQMDLEVKEISLD 1204
Score = 103 bits (256), Expect = 5e-21
Identities = 324/1742 (18%), Positives = 714/1742 (40%), Gaps = 223/1742 (12%)
Query: 18 DSHNSPKNSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYR 77
++ SPKNS L + ++ ++S ++ + ++ + LMK E+ ++
Sbjct: 817 EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK-AEQMHQ 875
Query: 78 AYRALAERYDHAMGELRHAHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRS 137
++ A + + E AH+ + + + N + L E T
Sbjct: 876 SFVAETSQRISKLQEDTSAHQNV---VAETLSALENKEKELQLLNDKVE--TEQAEIQEL 930
Query: 138 KKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLS-------KMETDLN--- 187
KK+ E+S E+Q L E L+ + + ++ + +E L+ ++ LN
Sbjct: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990
Query: 188 -----KAQNNARGLDDR-ASEAEIQVEILKESLMQLKADKDAGEVL------YNQCLETI 235
K+++ A +D+R S +E+ + +E L+ L+ ++ G Y E
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 236 ARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRML 295
++LE +L++ ++ +N K EL ++ K+ ++++ L K+A AEE ++ L
Sbjct: 1051 SKLECLLNECTSL-CENRKNELEQL---KEAFAKEHQEFL-------TKLAFAEERNQNL 1099
Query: 296 NDQIERTELEVETLRKNL-AEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNK 354
LE+ET+++ L +EM + +++ + ++ EI+ ++E +NK
Sbjct: 1100 -------MLELETVQQALRSEMTDNQNNSK-------SEAGGLKQEIMTLKEE----QNK 1141
Query: 355 IEKEA-EKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHEL----LEKHTEIERLQT 409
++KE + L+ +E+ +++ ++ LE+E + + ++ E + ++E +
Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEI 1201
Query: 410 LMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSK-QDFK-EEM 467
+ ++ +Q+E+ L+ + +S+KE+ L EL+ + DLE S QD + +E+
Sbjct: 1202 SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQ---TIRGDLETSNLQDMQSQEI 1258
Query: 468 QGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIK 527
G+ + E S L Q + + L+ + + + + +LQ E +++
Sbjct: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYEL- 1317
Query: 528 DDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSK 587
+ LN+ + + + V+ L +++ +L ++ E E+
Sbjct: 1318 --VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGE-FGEQPN 1374
Query: 588 DMNEVLME--NACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQL 645
+ + V + + + L L+D+ ++ E+Q+ LQ E IL D+ + S++
Sbjct: 1375 EQHPVSLAPLDESNSYEHLTLSDK--EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKM 1432
Query: 646 QIITESMQKILENNTVLEKSLSDAK---IEFEGLRIKSGDLEDCCKLLNDEKNNLQN--E 700
+ + + N VL +L + + ++ L ++ G + + ++L + +
Sbjct: 1433 SELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGD 1492
Query: 701 RSMLISQLEIVEEK--LSNLEKKVT----NLEEKYADVEKDKESAVNQVEELFASILVQK 754
S + LE + LSNLE V+ +++E + S V+ L A LV
Sbjct: 1493 SSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC------SSLQTYVDSLKAENLVLS 1546
Query: 755 ENHSNHKHS--SEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIEE 812
N N + E +L E +V L V L + ++ +L+
Sbjct: 1547 TNLRNFQGDLVKEMQLGLEEGLVPSLSS----SCVPDSSSLSSLGDSSFYRALLE----- 1597
Query: 813 LELKNFVLLTECEKLVEASKFS-DKVI-SELESENLMQL---------IEEEFLLHRIRK 861
+ + LL+ E +V A++ S D+V S L+ ENL + +EE L +
Sbjct: 1598 -QTGDMSLLSNLEGVVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV-- 1654
Query: 862 FKMDIHKVCGVLQIDSDGGGDN-EIKKEEIPISRILDKIESLESSLVKSQEENQQLLVEN 920
++ + K+ +++S G N EI++ E +S +++ L + E+ QQ L
Sbjct: 1655 YRQSLEKL--EEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSV 1712
Query: 921 SVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEVVNGV 980
++ + S + EK + E+ ++E E ++ Q + L + L I+ + +
Sbjct: 1713 TLEMES----KLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL--------LGIDTEDAI 1760
Query: 981 EKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAE---- 1036
+ N S +E E + V Q + + N +++ K + E
Sbjct: 1761 QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE 1820
Query: 1037 ---DENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRK 1093
D N + + + E+ F+ + LGN ++N L+
Sbjct: 1821 QSPDTNYEPPGEDKTQGSSECISELSFSG--PNALVPMDFLGNQEDIHN--------LQL 1870
Query: 1094 NFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKEN 1153
+ EN+ L IE D+++ + +K ++ H++E+++ TKI+
Sbjct: 1871 RVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-----KLHLQEVQL----MTKIE-- 1919
Query: 1154 LDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLEL------ 1207
+E + KKE L+E E + + LL VE E LN +L
Sbjct: 1920 ---ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE----TSEGLNSDLEMHADK 1972
Query: 1208 ---------LNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSA 1258
+ K N+ W+ ++L A +E + L +++ E
Sbjct: 1973 SSREDIGDNVAKVND--SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC 2030
Query: 1259 KSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNG 1318
+NE+ +++I LE E+ + + + + ++ + +L+ +S ++ + +
Sbjct: 2031 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 2090
Query: 1319 AQKDVVIETCLRKHSHQSARENEIV-LIPDGVSDLLT----LQTRIRAVEK------IMM 1367
+ + C++ + + E++ + VS+LL LQ +++++EK +
Sbjct: 2091 QSECL---HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2147
Query: 1368 EELKRRV----KQKSLTTESTP--YSSLEIATYPKVE-NRKKEIELVEENVFDRNSWRKK 1420
EL+ ++ K+K L + + + L + Y K+ ++ E LVE+ F +
Sbjct: 2148 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2207
Query: 1421 PKIRLLMKDI-PLDRNVDDQNSKYLK-----REHRRTNDHVLELCENNEHEPLSAPTVDH 1474
++ L + I L ++ K L +E R ND + + EN E E +
Sbjct: 2208 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2267
Query: 1475 AMICHRSDDSGRYLNYSSEL-DIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKL 1533
+I + +++ ++ + L V +L+L +++ + E+ ++I E+ +
Sbjct: 2268 LVILDAENSKAEVETLKTQIEEMARSLKVFELDL-VTLRSEKENLTKQIQEKQGQLSELD 2326
Query: 1534 AILKMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGA 1593
+L L++K + + + K+ + E ++ ++E+ EAV + M +
Sbjct: 2327 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2386
Query: 1594 SSLDREIPRRGSEQIGKLQFEVQNIQYIL----LKLAEENNNKVKNRISRKTGILLRRKL 1649
++ E R S + + + E + + LK +E + + +K R+ L R+L
Sbjct: 2387 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN-----LEREL 2441
Query: 1650 RV 1651
+
Sbjct: 2442 EI 2443
Score = 87.0 bits (214), Expect = 4e-16
Identities = 247/1339 (18%), Positives = 554/1339 (40%), Gaps = 163/1339 (12%)
Query: 331 LEKISKMENEILHVQENAEQLKNKIE-------KEAEKLEISEKHRGMLEKSNQNLQLEA 383
L+KI ++E ++ +++ +Q + +++ K+ +K+E + L++ NQ L
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLKRENQRLMEIC 76
Query: 384 ENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLA 443
E+L + HEL K +++ + + +S QIE Q L++ S+ ++ Q+
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQL---NSGKKQIEKLEQELKRCKSELERSQQ--- 130
Query: 444 LELKYGLLLLKDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKE 503
D+ L+ + +++ L + S + + + +K E ++
Sbjct: 131 ------AAQSADVSLNPCNTPQKI-----FTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 504 KLEREFHT--STEESNVLQRETHQIKDDIQH-LNERYQAMLEQLQSLGLNPNSFAASVRD 560
+LE E + + S L + T +D +H + + ++ L+ NS +R
Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
Query: 561 LQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEI 620
+ ++ E + + L+ +D N N+ L L + LR + E+
Sbjct: 240 DFSASYFSGEL--EVTPSRSTLQIGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKINEL 297
Query: 621 QQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEK---SLSDAKIEFEGLR 677
+ Q ++E ++ L QL+ ++ +++E VL K L +++
Sbjct: 298 ELRLQGHEKEMKGQVNKFQELQLQLE---KAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
Query: 678 IKSGDLEDCCKLLNDEKN-NLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDK 736
K LE K L ++ + QN S S +E+K+ EK+ +E+ + ++
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCS----LEQKIKEKEKE---FQEELSRQQRSF 407
Query: 737 ESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRV 796
++ + ++ A + + + N + +A L L ++ + L+ EF+Q+L R
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE----EFKQKLCRA 463
Query: 797 VNA----QIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEE 852
A QI+ L+ +EE++ +N +L + E+ K + E E +N+ Q + +
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ-----KAREVCHLEAELKNIKQCLNQ 518
Query: 853 EFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPIS-RILDKIESLESSLVKSQE 911
K K + + +N + E++ ++ L+K L+K +E
Sbjct: 519 SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE 578
Query: 912 ENQQLL--------VENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKV 963
+ + L E+ LL +L+ + E E+LK E+KT+ +++ E+ + + +
Sbjct: 579 HHIEQLNDKLSKTEKESKALLSALELKKKEYEELK-EEKTLFSCWKSENEKLLTQMESEK 637
Query: 964 ELLEENRQ-----LRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEK 1018
E L+ L+ + + E R ++ + +E+R + V ++ ++ +K
Sbjct: 638 ENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQK 697
Query: 1019 NSL--CRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGN 1076
+ + ++ D K E EN + L +L +++ N + + C
Sbjct: 698 LAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC----- 752
Query: 1077 LSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAET------SN 1130
DL+ E+ LR + K+A ++ NE +R LL D++ +
Sbjct: 753 ----YQDLHAEYESLRDLLKSKDA-SLVTNEDHQR---SLLAFDQQPAMHHSFANIIGEQ 804
Query: 1131 AEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLL 1190
E ++E ++S K + IL+ + + +E + N LQ + + L+
Sbjct: 805 GSMPSERSECRLEADQSPK-----NSAILQNRVDSLEF--SLESQKQMNSDLQKQCEELV 857
Query: 1191 H---EVEQHRVREEALNLELLNKENE--FKLWENEAAAFYHDLQMSSICLALLESKVSEL 1245
E+E++ ++ E ++ + + ++ KL E+ +A + + L+ LE+K EL
Sbjct: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA----HQNVVAETLSALENKEKEL 913
Query: 1246 TGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHIS 1305
++L+D+ + E + +++ LLE + ++L +S K++ +S+ IS
Sbjct: 914 ----QLLNDKVETEQAEIQELKKSNHLLEDSL----KELQLLSETLSLEKKEMSSI--IS 963
Query: 1306 LLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKI 1365
L KR +++ E K + S + ++ LI S + R
Sbjct: 964 L--NKREI-------EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER------- 1007
Query: 1366 MMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRL 1425
+KS++ S Y ++ + E E + + + + K K+
Sbjct: 1008 ----------EKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKY--KAAQEKNSKLEC 1055
Query: 1426 LMKDIPL----DRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRS 1481
L+ + +N +Q + +EH+ + E N++ L TV A+ +
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 1482 DDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQ 1541
D+ + + E G K E+ ++KE+ ++ + + L + Q + ++K +
Sbjct: 1116 DNQN---------NSKSEAGGLKQEI-MTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Query: 1542 DLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIP 1601
++E + S + + E E + + + + ++++S++ A+ V+ A ++E+
Sbjct: 1166 CQNLESEPIRNSVK--ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK 1223
Query: 1602 RRGSEQIGK-LQFEVQNIQ 1619
+ SE+ + LQ E+Q I+
Sbjct: 1224 LQESEKEKECLQHELQTIR 1242
Score = 85.9 bits (211), Expect = 9e-16
Identities = 244/1241 (19%), Positives = 506/1241 (40%), Gaps = 150/1241 (12%)
Query: 398 LEKHTEIE-RLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQR---NLALELKYGLLLL 453
L+K E+E +L L + Q++S A QK + + E+ NL E + + +
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLKRENQRLMEIC 76
Query: 454 KDLELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTST 513
+ LE +KQ E+Q V+E+ ++NF Q+ +++ K+ EKLE+E
Sbjct: 77 ESLEKTKQKISHELQ--VKES----QVNF--------QEGQLNSGKKQIEKLEQELKRCK 122
Query: 514 EESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSF--AASVRDLQNENFMLKET 571
E Q+ + N +++ + L P+ + + DL+ + E
Sbjct: 123 SELERSQQAAQSADVSLNPCNTP-----QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177
Query: 572 CKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGL-----RGTVKEIQQFCQV 626
K+ +E +AL+ K + A M + + + T + Q
Sbjct: 178 RKRLEAEVKALQAKKASQT---LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQR 234
Query: 627 LQEEKSILAD------EKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKS 680
+ A E + S LQI N+ L K + + LR K
Sbjct: 235 TPIRRDFSASYFSGELEVTPSRSTLQIGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKI 294
Query: 681 GDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAV 740
+LE + E N+ L QLE + +L EK + ++ + A
Sbjct: 295 NELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
Query: 741 NQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQ 800
+ L + E+ S + ++E+ +LE ++ ++ EF++EL R +
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEK-------EFQEELSR--QQR 405
Query: 801 IEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIEEEFLLHRIR 860
+ Q CI+ + ++L +A + + +EL+ + ++ L + +
Sbjct: 406 SFQTLDQECIQ-------MKARLTQELQQAKNMHNVLQAELDKLTSV----KQQLENNLE 454
Query: 861 KFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQ-----Q 915
+FK K+C Q ++IK+ E + R +++++ E++L+KS E +
Sbjct: 455 EFK---QKLCRAEQAFQ----ASQIKENE--LRRSMEEMKK-ENNLLKSHSEQKAREVCH 504
Query: 916 LLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIE 975
L E + L Q Q+ E++K + + E +++E+ I Q++ LE +L++
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK--INQQENSLTLE---KLKLA 559
Query: 976 VVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAK--- 1032
V + ++ + S+ L + + +L ++E+ +L + +LK+ K
Sbjct: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLF 619
Query: 1033 SSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLR 1092
S + EN + + NL +I E ++ + + H N ++++E
Sbjct: 620 SCWKSENEKLLTQ-MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE----N 674
Query: 1093 KNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKE 1152
+ E++ NV ++S+E ++L M+ + K AE S+ + + IE + ++ + T E
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQK-AEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 1153 NLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKT-----LLHEVEQHRV----REEAL 1203
+L+ ++ S M+ + + L+ E+L+ +K+ + +E Q + ++ A+
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 1204 NLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLEN 1263
+ N E +E + + S A+L+++V L + +S +
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 1264 EHMREIISLLESEIGGLKEQLSAYV----PLVSSLKEDFNSLEHISLLWTKRNSVVGNGA 1319
E + +I +E + ++ ++V +S L+ED A
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED-------------------TSA 894
Query: 1320 QKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSL 1379
++VV ET S +E E+ L+ D V T Q I+ ++K L+ +K+ L
Sbjct: 895 HQNVVAETL----SALENKEKELQLLNDKVE---TEQAEIQELKK-SNHLLEDSLKELQL 946
Query: 1380 TTESTPYSSLEIATYPKVENRKKEIELVEEN--VFDRNSWRKKPKIRLLMKDIPLDRNVD 1437
+E+ E+++ + R+ E EL +EN + + N+ + K+ L+ K +D
Sbjct: 947 LSETLSLEKKEMSSIISLNKREIE-ELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Query: 1438 DQNSKY--LKREHRRTNDHVLELCE--NNEHEPLS-----APTVDHAMICHRSDDSGRYL 1488
++ L ++++ +L+ CE N +E LS A + + C ++ +
Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065
Query: 1489 NYSSELDIEKE-LGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKT 1547
N +EL+ KE + E + E ++ +LE L ++ AL+
Sbjct: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLE--------LETVQQALRSEMTDN 1117
Query: 1548 ETKKKSKQGN-DIEYETVKRHIEEVEEAVMQQVSINDQMAK 1587
+ KS+ G E T+K ++++ V + N+Q+ K
Sbjct: 1118 QNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMK 1158
Score = 81.6 bits (200), Expect = 2e-14
Identities = 211/1049 (20%), Positives = 412/1049 (39%), Gaps = 191/1049 (18%)
Query: 622 QFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSG 681
Q Q L+ + L EK QL + + QK + + + K E L+ ++
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQK-------VENEKTEGTNLKRENQ 70
Query: 682 DLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKY----ADVEKDKE 737
L + C+ L K + +E + SQ+ E +L++ +K++ LE++ +++E+ ++
Sbjct: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
Query: 738 SA---------VNQVEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVE 788
+A N +++F + L + +S K+ N E ++E +RL
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKE-----VEERKRL---- 181
Query: 789 FEQELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFS---DKVISELESEN 845
E E+ + + + Q + ++ +S FS +K S L S +
Sbjct: 182 -EAEVKALQAKKASQTLPQATMNHRDI--------ARHQASSSVFSWQQEKTPSHLSSNS 232
Query: 846 LMQLIEEEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESS 905
I +F ++++ LQI + P +LD++++
Sbjct: 233 QRTPIRRDFSASYFSG-ELEVTPSRSTLQIGKRDANSSFFGNSSSP--HLLDQLKA---- 285
Query: 906 LVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVEL 965
+NQ+L + + L LQ H+ E ++ + +E + L+K KVEL
Sbjct: 286 ------QNQELRNKINELELRLQGHEKE----------MKGQVNKFQELQLQLEKAKVEL 329
Query: 966 LEENRQL---RIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLC 1022
+E+ + L R E+V + +++ + AL+ ++ +L + Q +N + ++ C
Sbjct: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC-QRQNAE-----SARC 383
Query: 1023 RNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNN 1082
+K+ + ++E LS ++ E + K L + L +++N
Sbjct: 384 SLEQKIKEKEKEFQEE----------LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 1083 DLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKM 1142
L E L K VK+ L ++E ++L ++ +A++ E R +EE+K
Sbjct: 434 VLQAE---LDKLTSVKQQ----LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 1143 EQEESTKIKENLDRQI------LEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQH 1196
E E R++ L+ + C+N + +A T Q +T+L ++++
Sbjct: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ---ETMLRDLQEK 543
Query: 1197 -RVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLA-LLESKVSELTGVCKILDD 1254
+E +L LE L A A DL+ C LL+ + + + L+D
Sbjct: 544 INQQENSLTLEKLKL----------AVA---DLEKQRDCSQDLLKKREHHI----EQLND 586
Query: 1255 ESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSV 1314
+ S E++ + + L + E LKE+ + L S K + L T+ S
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKT----LFSCWKSENEKL------LTQMESE 636
Query: 1315 VGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRV 1374
N K +ETCL+ +S NE V + D L IR + ++
Sbjct: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLE--MDRENLSVEIRNLHNVL-------- 686
Query: 1375 KQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRK------KPKIRLLMK 1428
KS+ E+ + +E+ + ++K + E+ EN+ + S + K++LL
Sbjct: 687 DSKSVEVETQKLAYMELQQKAEFSDQKHQKEI--ENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 1429 DI-PLDRNVDDQNSKYLK-REHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGR 1486
+I DR D +++Y R+ ++ D L N +H+ S D H S
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKD--ASLVTNEDHQR-SLLAFDQQPAMHHS----- 796
Query: 1487 YLNYSSEL-DIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKK 1545
+ N E + E +LE +S K AIL+ + L+
Sbjct: 797 FANIIGEQGSMPSERSECRLEADQSPKNS-------------------AILQNRVDSLEF 837
Query: 1546 KTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSLDREIPRRGS 1605
E++K+ + E + + E+EE +M+ A + + S
Sbjct: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMK---------------AEQMHQSFVAETS 882
Query: 1606 EQIGKLQFEVQNIQYILLKLAEENNNKVK 1634
++I KLQ + Q ++ + NK K
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEK 911
Score = 42.4 bits (98), Expect = 0.011
Identities = 157/809 (19%), Positives = 315/809 (38%), Gaps = 123/809 (15%)
Query: 841 LESENLMQLIEEEFLLHRIRK------FKMDIHKVCGVLQ---IDSDGGGDNEIKKEEIP 891
L + L ++ E E L +++K F++D + Q ++++ +K+E
Sbjct: 12 LPTRTLQKIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLKREN-- 69
Query: 892 ISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENM 951
R+++ ESLE + K E Q + + G L + + EKL+ E K + E E
Sbjct: 70 -QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 952 REQNVILQKDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEEN 1011
++ Q V L N +I + S S L +E+
Sbjct: 129 QQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL--------------KEKY 171
Query: 1012 GKMLDEKNSLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALC 1071
K ++E+ L V L+ K+S + M H +A + +F + EK
Sbjct: 172 NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQAS--SSVFSWQQ--EKTP-- 225
Query: 1072 EHLGNLSHLNNDLNQEFGVLRKNFEVKEAENVYLNESIE-RMDKELLEMDKR-LKAAETS 1129
SHL++ N + +R++F Y + +E + L++ KR ++
Sbjct: 226 ------SHLSS--NSQRTPIRRDFSAS-----YFSGELEVTPSRSTLQIGKRDANSSFFG 272
Query: 1130 NAEFSRHIEELKMEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTL 1189
N+ +++LK + +E L +I E H+K EMK
Sbjct: 273 NSSSPHLLDQLKAQNQE-------LRNKINELELRLQGHEK--------------EMKGQ 311
Query: 1190 LHEVEQHRVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTG-- 1247
+++ ++ +++ E +EL+ KE +E +S LE K+ +LT
Sbjct: 312 VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDL 371
Query: 1248 VCKILDDESSAKSLE---NEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHI 1304
C+ + ES+ SLE E +E L + + + + + L ++ +++
Sbjct: 372 SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNM 431
Query: 1305 -SLLWTKRNSVVGNGAQKDVVIE-----TCLRKHSHQSA--RENEIVLIPDGV---SDLL 1353
++L + + + Q + +E C + + Q++ +ENE+ + + ++LL
Sbjct: 432 HNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLL 491
Query: 1354 TLQTRIRAVEKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIEL--VEENV 1411
+ +A E +E + +KQ S A K +N +E L ++E +
Sbjct: 492 KSHSEQKAREVCHLEAELKNIKQ-------CLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
Query: 1412 FDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLKREH--RRTNDHV-------------L 1456
+ + K++L + D+ R+ K KREH + ND + L
Sbjct: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLK--KREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 1457 ELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSELDIEKELGVDKLELSKSVKEKTE 1516
EL + E+E L C +S++ SE + + ++ LE ++
Sbjct: 603 EL-KKKEYEELKEEKT--LFSCWKSENEKLLTQMESEKE-NLQSKINHLETCLKTQQIKS 658
Query: 1517 DDKRRILERLSSDGQKLAI----LKMALQDLKKKTETKKKSKQGNDIEYE-TVKRHIEEV 1571
+ + L D + L++ L L + ET+K + + E + ++H +E+
Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEI 718
Query: 1572 EEAVMQQVSINDQMAKNVEEGASSLDREI 1600
E ++ + Q+ +++E L EI
Sbjct: 719 ENMCLKTSQLTGQV-EDLEHKLQLLSNEI 746
>MYSN_DROME (Q99323) Myosin heavy chain, non-muscle (Zipper protein)
(Myosin II) (Non-muscle MHC)
Length = 2057
Score = 143 bits (360), Expect = 4e-33
Identities = 249/1213 (20%), Positives = 493/1213 (40%), Gaps = 171/1213 (14%)
Query: 299 IERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKE 358
+E T+ E + ++K E+ + R+ L L + E K + ++ AEQL+ +IE
Sbjct: 929 LEVTKQEEKLVQKE-DELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELC 987
Query: 359 AEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIERLQTLMHGEHSNF 418
AE +E+ R L Q L+ + L RI ++ +L E ++L+ +
Sbjct: 988 AE----AEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQL 1043
Query: 419 IQIESALQALQ----KLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGIVEEN 474
+ E+A Q LQ +L ++ +K + +LAL LLK+ +L ++ + Q + EE
Sbjct: 1044 EEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEE 1103
Query: 475 KTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLN 534
+ L K + + + E++E+L ++ E ++ ++ D + LN
Sbjct: 1104 EKAKHL-------AKLKAKHEATITELEERLHKDQQQRQESDRSKRKIETEVADLKEQLN 1156
Query: 535 ERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEA-LREKSKDMNEVL 593
ER + E L ++ + E+ K T +K E E+ L E +D+
Sbjct: 1157 ERRVQVDEMQAQLAKREEELTQTLLRIDEES-ATKATAQKAQRELESQLAEIQEDLEAEK 1215
Query: 594 MENACMEFSLLGLNDELDGLRGTV------------------KEIQQFCQVLQEE----K 631
A E L++EL+ L+ + +E+ + L+EE +
Sbjct: 1216 AARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHE 1275
Query: 632 SILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLN 691
+LAD + +L I + ++ + + TVLEK+ L ++ DL + +N
Sbjct: 1276 GVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGT-------LEAENADLATELRSVN 1328
Query: 692 DEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASIL 751
+ R SQ+ ++ KL+ +E+ + L+EK ++++ E+ NQ+EE
Sbjct: 1329 SSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEA----- 1383
Query: 752 VQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIE 811
+ + A + + N+ L E Q+L + E Q+L L + +
Sbjct: 1384 ---------ELKASAAVKSASNMESQLTEAQQLLEEETRQKLG-----------LSSKLR 1423
Query: 812 ELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLI-----EEEFLLHRIRKFKMDI 866
++E + L + E+ EA + ++ ++E+ ++ MQ I E+ L + + K +
Sbjct: 1424 QIESEKEALQEQLEEDDEAKRNYERKLAEVTTQ--MQEIKKKAEEDADLAKELEEGKKRL 1481
Query: 867 HKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVE---NSVL 923
+K +I+ E + ++ + + L+ S K Q E + +E
Sbjct: 1482 NK---------------DIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTK 1526
Query: 924 LGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDK-VELLEENRQLRIEVVNGVEK 982
+ L++ Q +K+ E+K + ++ R+ ++K ++L +R+L +
Sbjct: 1527 VLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDL 1586
Query: 983 ENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDENSVM 1042
EN+ K+ LQ E+ +L T + ++ K +L +++LK ED
Sbjct: 1587 ENKRKT----LQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELED----- 1637
Query: 1043 FHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSHLNNDLNQEFGVLRKNFEVKEAEN 1102
D+ + L E+ N+ L + ++ L E E +
Sbjct: 1638 --DLQLTEDAKLRLEV-----------------NMQALRSQFERD---LLAKEEGAEEKR 1675
Query: 1103 VYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQEESTKIKENLDRQILEQS 1162
L + + ++ EL E K+ AA S + ++E++ E K+K
Sbjct: 1676 RGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVK----------- 1724
Query: 1163 ENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNLELLNKENEFKLWENEAA 1222
E+ + H K+ LQ ++K L + E+ + +E L + + K E E
Sbjct: 1725 EDALKHAKK----------LQAQVKDALRDAEEAKAAKEELQALSKEADGKVKALEAEVL 1774
Query: 1223 AFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKE 1282
DL S E++ EL ++ S E + I+ LE E+ +E
Sbjct: 1775 QLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELE--EE 1832
Query: 1283 QLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSAR--EN 1340
Q ++ V L S K I L T+ + N + + R++ A+ E
Sbjct: 1833 QSNSEVLLDRSRKAQL----QIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEI 1888
Query: 1341 EIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRR-VKQKSLTTESTPYSSLEIATYPKVEN 1399
E + + TL+ +I +E+ + E K R ++QK+ L + +E+
Sbjct: 1889 ETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTM----NIED 1944
Query: 1400 RKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDD-QNSKYLKREHRRTNDHVLEL 1458
++ ++ +E + NS +I+LL ++ LD ++ Q K KR+++R + ++E
Sbjct: 1945 ERRHVDQHKEQMDKLNS-----RIKLLKRN--LDETEEELQKEKTQKRKYQRECEDMIES 1997
Query: 1459 CENNEHEPLSAPT 1471
E E S T
Sbjct: 1998 QEAMNREINSLKT 2010
Score = 141 bits (356), Expect = 1e-32
Identities = 225/1149 (19%), Positives = 465/1149 (39%), Gaps = 149/1149 (12%)
Query: 128 HTSARPTHRSKKNERSSEESNGEVQTLREALAKMQS--------------DKDALFLQYQ 173
+T +P K E + E++ +RE L + +K L Q Q
Sbjct: 922 YTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQ 981
Query: 174 ESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYNQCLE 233
+E ++ E ++ + L+D E E ++E +E ++ L +K E+
Sbjct: 982 AEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLEL------- 1034
Query: 234 TIARLESMLSQKDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSR 293
I LE L ++ EA K +L +V Q KI E +AL ++ ++
Sbjct: 1035 NIQDLEEQLEEE---EAARQKLQLEKV------------QLDAKIKKYEEDLALTDDQNQ 1079
Query: 294 MLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKN 353
L + + E L + LAE E+ L+ L I+++E E LH + Q
Sbjct: 1080 KLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATITELE-ERLHKDQQQRQ--- 1135
Query: 354 KIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIER------- 406
E + K +I + + E+ N+ +++ + + ++A ++ EL + I+
Sbjct: 1136 --ESDRSKRKIETEVADLKEQLNER-RVQVDEMQAQLAKREEELTQTLLRIDEESATKAT 1192
Query: 407 LQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALE---LKYGLLLLKDLELSKQDF 463
Q S +I+ L+A + ++++K +R+L+ E LK LL D ++Q+
Sbjct: 1193 AQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQEL 1252
Query: 464 KEE-------MQGIVEENKTLHELNFSSTRSLKKQQM-----EISKLKEIKEKLEREFHT 511
+ + ++ +EE HE + R Q++ ++ L++ K LE+ T
Sbjct: 1253 RSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGT 1312
Query: 512 STEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKET 571
E+ L E + Q + R + Q+ L + +++ L+E
Sbjct: 1313 LEAENADLATELRSVNSSRQENDRRRKQAESQIAEL-------QVKLAEIERARSELQEK 1365
Query: 572 CKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEK 631
C K E E + + ++ L +A ++ + + E QQ + +K
Sbjct: 1366 CTKLQQEAENITNQLEEAE--LKASAAVK--------SASNMESQLTEAQQLLEEETRQK 1415
Query: 632 SILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLN 691
L+ + + S+ + + E +++ E E+ L++ + + ++ K+ + D K L
Sbjct: 1416 LGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELE 1475
Query: 692 DEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEELFASIL 751
+ K L + +E +E ++ L + L++ ++ + E A ++E +L
Sbjct: 1476 EGKKRLNKD-------IEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVL 1528
Query: 752 VQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQELDRVVNAQIEMFILQNCIE 811
++ N + LA + I + +E+ + E ++ +V++ E+ + IE
Sbjct: 1529 ELEKKQKNF----DKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIE 1584
Query: 812 ELELKNFVLLTECEKLVEASKFSDKVISELE------SENLMQL------IEEEFLLHRI 859
+LE K L E + L +DK + ELE L +L +E++ L
Sbjct: 1585 DLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTED 1644
Query: 860 RKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVE 919
K +++++ Q + D E +E+ ++ ++ LE+ L + +++ +
Sbjct: 1645 AKLRLEVNMQALRSQFERDLLAKEEGAEEK--RRGLVKQLRDLETELDEERKQRTAAVAS 1702
Query: 920 NSVLLGSLQQ--------HQSEGEKLKLEKKTVEQEFENMRE-QNVILQKDKVELLEEN- 969
L G L++ ++ + + LK KK Q + +R+ + K++++ L +
Sbjct: 1703 KKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEA 1762
Query: 970 ----RQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNV 1025
+ L EV+ E S+ A + E EL + + M+DEK L +
Sbjct: 1763 DGKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARI 1822
Query: 1026 SDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGN---LSHLNN 1082
+ L++ + E NS + D + L + E TE EK ++ L N
Sbjct: 1823 ATLEE-ELEEEQSNSEVLLDRSRKAQLQI--EQLTTELANEKSNSQKNENGRALLERQNK 1879
Query: 1083 DLNQEFGVLRKNFEVK--------EAENVYLNESIERMDKELL-------EMDKRLKAAE 1127
+L + + K EA+ L E +E KE L +MDK++K
Sbjct: 1880 ELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELT 1939
Query: 1128 TSNAEFSRHIEELKMEQEESTK----IKENLD---RQILEQSENCMNHKKEIEHLNEANE 1180
+ + RH+++ K + ++ +K NLD ++ ++ +++E E + E+ E
Sbjct: 1940 MNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQE 1999
Query: 1181 TLQFEMKTL 1189
+ E+ +L
Sbjct: 2000 AMNREINSL 2008
Score = 114 bits (285), Expect = 2e-24
Identities = 195/956 (20%), Positives = 385/956 (39%), Gaps = 145/956 (15%)
Query: 138 KKNERSSEESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKM-----ETDLNKAQNN 192
++++RS + EV L+E L + + D + Q + E L++ E KA
Sbjct: 1135 QESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1194
Query: 193 ARGLDDRASEAEIQVEILKESLMQLKADK------DAGEVLYNQCLETI--ARLESMLSQ 244
+ + AEIQ ++ E + KA+K + E L N+ L+++ + L
Sbjct: 1195 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRS 1254
Query: 245 KDNIEAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIALAEENSRMLNDQIERTEL 304
K E LK+ L V + VL + + E NS +NDQ+E
Sbjct: 1255 KREQELATLKKSLEEETVNHEGVLADMRHKHSQ-----------ELNS--INDQLENLRK 1301
Query: 305 EVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEI 364
L K + E L+ S+ EN+ +Q +++I + KL
Sbjct: 1302 AKTVLEKAKGTLEAENADLATELRSV--NSSRQEND-----RRRKQAESQIAELQVKLAE 1354
Query: 365 SEKHRGMLEKSNQNLQLEAENLVQRI--------------ASKDHELLEKHTEIERLQTL 410
E+ R L++ LQ EAEN+ ++ ++ + +L E +E
Sbjct: 1355 IERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQ 1414
Query: 411 MHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGI 470
G S QIES +ALQ+ + + +RN +L +++++ ++ + + +
Sbjct: 1415 KLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKEL 1474
Query: 471 VEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDI 530
E K L++ + R +K+ + +L + K+K++ E +T E
Sbjct: 1475 EEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIEL-------------- 1520
Query: 531 QHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMN 590
E + + +L+ N + A + + + ++T ++E EKE
Sbjct: 1521 ----EAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKET--------- 1567
Query: 591 EVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITE 650
+L ++ ELD +++++ + LQ E LA+ + T +
Sbjct: 1568 -----------KVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGT-------ADK 1609
Query: 651 SMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEI 710
++ ++ + LE L++ K + E +LED +L D K L+ L SQ E
Sbjct: 1610 NVHELEKAKRALESQLAELKAQNE-------ELEDDLQLTEDAKLRLEVNMQALRSQFER 1662
Query: 711 --------VEEKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL---FASILVQKENHSN 759
EEK L K++ +LE + + K + +AV ++L I E H+
Sbjct: 1663 DLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNK 1722
Query: 760 HKHSSEARLANLENIVRVL---QEEQRLGKVEFE---QELDRVVNA-QIEMFILQNCIEE 812
K + L+ V+ EE + K E + +E D V A + E+ L +
Sbjct: 1723 VKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEADGKVKALEAEVLQLTEDLAS 1782
Query: 813 LELKNFVLLTECEKLVE-----ASKFS---------DKVISELESENLMQLIEEEFLLHR 858
E TE ++L E A+K S + I+ LE E + E LL R
Sbjct: 1783 SERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDR 1842
Query: 859 IRKFKMDIHKVCGVLQIDSDGGGDNE-----IKKEEIPISRILDKIESLESSLVKSQEEN 913
RK ++ I ++ L + NE ++++ + L +IE+ + + VK+
Sbjct: 1843 SRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIAT 1902
Query: 914 QQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLR 973
+ + N +Q ++EG++ L++K + + ++E + ++ ++ + + Q+
Sbjct: 1903 LEAKIANLE-----EQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQM- 1956
Query: 974 IEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLK 1029
+ +N + K L + E+ + + + +Q E M++ + ++ R ++ LK
Sbjct: 1957 -DKLN--SRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLK 2009
Score = 111 bits (278), Expect = 1e-23
Identities = 220/1100 (20%), Positives = 438/1100 (39%), Gaps = 115/1100 (10%)
Query: 593 LMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESM 652
L+E E L+ DEL +R + + + Q + + EK+TL QLQ E
Sbjct: 928 LLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELC 987
Query: 653 QKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVE 712
+ E+ + L + + + L + + E+ L EK L+ L QLE E
Sbjct: 988 AEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEE 1047
Query: 713 EKLSNLEKKVTNLEEKYADVEKDKESAVNQVEEL-------------FASILVQKENHSN 759
L+ + L+ K E+D +Q ++L + L ++E +
Sbjct: 1048 AARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAK 1107
Query: 760 H----KHSSEARLANLENIVRVLQEEQRLG-----KVEFE-QELDRVVN---AQIEMFIL 806
H K EA + LE + Q++++ K+E E +L +N Q++
Sbjct: 1108 HLAKLKAKHEATITELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQA 1167
Query: 807 QNCIEELELKNFVLLTECEKLVEASKFSDKVISELES---ENLMQLIEEEFLLHRIRKFK 863
Q E EL +L + E +A+ + K ELES E L E+ + K +
Sbjct: 1168 QLAKREEELTQTLLRIDEESATKAT--AQKAQRELESQLAEIQEDLEAEKAARAKAEKVR 1225
Query: 864 MDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVL 923
D+ + L+ + D ++E+ R E ++L KS EE V + +
Sbjct: 1226 RDLSEELEALKNELLDSLDTTAAQQELRSKR-----EQELATLKKSLEEE---TVNHEGV 1277
Query: 924 LGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV--VNGVE 981
L ++ S+ E ++ + EN+R+ +L+K K L EN L E+ VN
Sbjct: 1278 LADMRHKHSQ------ELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSR 1331
Query: 982 KEN-----RSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAE 1036
+EN +++S +A LQ ++ E+ + QE+ K+ E ++ + + + S+A
Sbjct: 1332 QENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAV 1391
Query: 1037 DENSVMFHDVLALSNL-------NLVYEIFFTENMVEKRALCEHL-------GNLSHLNN 1082
S M + L L + EK AL E L N
Sbjct: 1392 KSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLA 1451
Query: 1083 DLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKM 1142
++ + ++K E L E +R++K++ +++++K N + ++++
Sbjct: 1452 EVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQS 1511
Query: 1143 EQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEA 1202
E E++T E ++LE + N K + +E + E T E + + +
Sbjct: 1512 ELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLS 1571
Query: 1203 LNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLE 1262
++ EL ++ + EN+ ++L + + V EL + L+ + + +
Sbjct: 1572 VSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQ 1631
Query: 1263 NEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKD 1322
NE + + + L E L+ + A L S + D + E + KR +V +
Sbjct: 1632 NEELEDDLQLTEDAKLRLEVNMQA---LRSQFERDLLAKEEGA--EEKRRGLVKQLRDLE 1686
Query: 1323 VVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTE 1382
++ ++ + A + ++ DL ++T + K+ + LK K ++ +
Sbjct: 1687 TELDEERKQRTAAVASKKKL------EGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKD 1740
Query: 1383 STPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSK 1442
+ + + + K+E++ + + K++ L ++ L D +S+
Sbjct: 1741 A-------LRDAEEAKAAKEELQALSKEA--------DGKVKALEAEV-LQLTEDLASSE 1784
Query: 1443 YLKREHRRTNDHVLELCENN---------EHEPLSA--PTVDHAMICHRSDDSGRYLNYS 1491
+R D + E NN E L A T++ + +S +S L+ S
Sbjct: 1785 RARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQS-NSEVLLDRS 1843
Query: 1492 SELDIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQKLAILKMALQDLKKKTETKK 1551
+ ++ E +L KS +K E+ R +LER + + LK L +++ TK
Sbjct: 1844 RKAQLQIEQLTTELANEKSNSQKNENG-RALLERQNKE------LKAKLAEIETAQRTKV 1896
Query: 1552 KSKQGN-DIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSL--DREIPRRGSEQI 1608
K+ + + ++ +E + + Q N +M K ++E ++ +R + EQ+
Sbjct: 1897 KATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQM 1956
Query: 1609 GKLQFEVQNIQYILLKLAEE 1628
KL ++ ++ L + EE
Sbjct: 1957 DKLNSRIKLLKRNLDETEEE 1976
Score = 106 bits (265), Expect = 5e-22
Identities = 236/1202 (19%), Positives = 480/1202 (39%), Gaps = 168/1202 (13%)
Query: 537 YQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMEN 596
YQ L+QL ++ + + AA ++ L+N + + +++ + L E +K +++ +
Sbjct: 890 YQKRLQQLNAIRIIQRNCAAYLK-LRNWQWW------RLYTKVKPLLEVTKQEEKLVQK- 941
Query: 597 ACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKIL 656
E L + ++LD L +E ++ Q EK+ LA++ + ES +++
Sbjct: 942 ---EDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLM 998
Query: 657 ENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLS 716
LE + + + E + E+ L EK L+ L QLE E
Sbjct: 999 ARKQELEDMMQELETRIE-------EEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQ 1051
Query: 717 NLEKKVTNLEEKYADVEKDKESAVNQVEELF-------------ASILVQKENHSNH--- 760
L+ + L+ K E+D +Q ++L + L ++E + H
Sbjct: 1052 KLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAK 1111
Query: 761 -KHSSEARLANLENIVRVLQEEQRLG-----KVEFE-QELDRVVN---AQIEMFILQNCI 810
K EA + LE + Q++++ K+E E +L +N Q++ Q
Sbjct: 1112 LKAKHEATITELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAK 1171
Query: 811 EELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIE----EEFLLHRIRKFKMDI 866
E EL +L + E +A+ + K ELES+ L ++ E E+ + K + D+
Sbjct: 1172 REEELTQTLLRIDEESATKAT--AQKAQRELESQ-LAEIQEDLEAEKAARAKAEKVRRDL 1228
Query: 867 HKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGS 926
+ L+ + D ++E+ R E ++L KS EE V + +L
Sbjct: 1229 SEELEALKNELLDSLDTTAAQQELRSKR-----EQELATLKKSLEEET---VNHEGVLAD 1280
Query: 927 LQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQLRIEV--VNGVEKEN 984
++ S+ E ++ + EN+R+ +L+K K L EN L E+ VN +EN
Sbjct: 1281 MRHKHSQ------ELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQEN 1334
Query: 985 -----RSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDEN 1039
+++S +A LQ ++ E+ + QE+ K+ E ++ + + + S+A
Sbjct: 1335 DRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSA 1394
Query: 1040 SVMFHDVLALSNL-------NLVYEIFFTENMVEKRALCEHLG-------NLSHLNNDLN 1085
S M + L L + EK AL E L N ++
Sbjct: 1395 SNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVT 1454
Query: 1086 QEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKMEQE 1145
+ ++K E L E +R++K++ +++++K N + ++++ E E
Sbjct: 1455 TQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELE 1514
Query: 1146 ESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREEALNL 1205
++T E ++LE + N K + +E + E T E + + +++
Sbjct: 1515 DATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSR 1574
Query: 1206 ELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSLENEH 1265
EL ++ + EN+ ++L + + V EL + L+ + + +NE
Sbjct: 1575 ELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEE 1634
Query: 1266 MREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGNGAQKDVVI 1325
+ + + L E L+ + A L S + D + E + KR +V + +
Sbjct: 1635 LEDDLQLTEDAKLRLEVNMQA---LRSQFERDLLAKEEGAE--EKRRGLVKQLRDLETEL 1689
Query: 1326 ETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEELKRRVKQKSLTTESTP 1385
+ ++ + A + ++ DL ++T + K+ + LK K ++ ++
Sbjct: 1690 DEERKQRTAAVASKKKLE------GDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALR 1743
Query: 1386 YSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLDRNVDDQNSKYLK 1445
+ A +++ KE + K++ L ++ L D +S+ +
Sbjct: 1744 DAEEAKAAKEELQALSKEAD---------------GKVKALEAEV-LQLTEDLASSERAR 1787
Query: 1446 REHRRTNDHVLELCENN---------EHEPLSA--PTVDHAMICHRSDDSGRYLNYSSEL 1494
R D + E NN E L A T++ + +S+ S L+ S +
Sbjct: 1788 RAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSN-SEVLLDRSRKA 1846
Query: 1495 DIEKELGVDKLELSKSVKEKTEDDKRRILERLSSDGQ----------------------- 1531
++ E +L KS +K E+ R +LER + + +
Sbjct: 1847 QLQIEQLTTELANEKSNSQKNENG-RALLERQNKELKAKLAEIETAQRTKVKATIATLEA 1905
Query: 1532 KLAILKMALQDLKKKTETKKKSKQGND-------IEYETVKRHIEEVEEAVMQQVSINDQ 1584
K+A L+ L++ K+ ++K+ + D + E +RH+++ +E + + S
Sbjct: 1906 KIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKL 1965
Query: 1585 MAKNVEEGASSLDREIPRRGSEQIGKLQFEVQNIQYILLKLAEENN---NKVKNRISRKT 1641
+ +N++E L +E Q K Q E ++ +++ E N N +K ++ R
Sbjct: 1966 LKRNLDETEEELQKE-----KTQKRKYQRECED----MIESQEAMNREINSLKTKLRRTG 2016
Query: 1642 GI 1643
GI
Sbjct: 2017 GI 2018
Score = 58.5 bits (140), Expect = 1e-07
Identities = 104/598 (17%), Positives = 233/598 (38%), Gaps = 54/598 (9%)
Query: 6 ESESRRLYSWWWDSHNSPKNSKWLLENLTDIDTKVKSMIKLIEEEADSFARRAEMYYKKR 65
ESE L + + +N + L ++ T+++ + K EE+AD A+ E K+
Sbjct: 1426 ESEKEALQEQLEEDDEAKRNYE---RKLAEVTTQMQEIKKKAEEDAD-LAKELEEGKKRL 1481
Query: 66 PELMKLVEEFYRAYRALAERYDHAMGELRHAHKTMPEAFPNSAYYIL-------NDDSPC 118
+ ++ +E + A +R D + +++ + +L N D
Sbjct: 1482 NKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKIL 1541
Query: 119 GSLGPDAESHTSARPTHRSKKNERSS---------EESNGEVQTLREALAKMQSDKDALF 169
+E R T + E+ + +E+ +++ L +Q++ D L
Sbjct: 1542 AEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1601
Query: 170 LQYQESLENLSKMETDLNKAQNNARGLDDRASEAEIQVEILKESLMQLKADKDAGEVLYN 229
+ +N+ ++E ++ L + E E +++ +++ ++L+ + A +
Sbjct: 1602 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFE 1661
Query: 230 QCLETIARLESMLSQKDNI--EAKNLKQELTRVVVQKDTVLLQYKQCLEKIPMLENKIAL 287
+ L +A+ E ++ + + ++L+ EL Q+ + K+ + +E + +
Sbjct: 1662 RDL--LAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEM 1719
Query: 288 AEENSRMLNDQIERTELEVETLRKNLAEMNEERDSLSVLYHHCLEKISKMENEILHVQEN 347
+ ++ + +V+ ++ E ++ L L K+ +E E+L + E+
Sbjct: 1720 HNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEADGKVKALEAEVLQLTED 1779
Query: 348 -AEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLEAENLVQRIASKDHELLEKHTEIER 406
A + + E E+ E++E+ K + + E L RIA+ + EL E+ + E
Sbjct: 1780 LASSERARRAAETERDELAEEIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSE- 1837
Query: 407 LQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLAL------ELKYGLLLLKDLELSK 460
L+ +QIE L S SQK + AL ELK L ++ + +K
Sbjct: 1838 --VLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTK 1895
Query: 461 ------------QDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEIS-------KLKEI 501
+ +E+++ +E + N + +K+ M I + KE
Sbjct: 1896 VKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQ 1955
Query: 502 KEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLNPNSFAASVR 559
+KL + + E + K + + M+E +++ NS +R
Sbjct: 1956 MDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2013
>CING_XENLA (Q9PTD7) Cingulin
Length = 1360
Score = 142 bits (359), Expect = 6e-33
Identities = 206/1013 (20%), Positives = 436/1013 (42%), Gaps = 161/1013 (15%)
Query: 146 ESNGEVQTLREALAKMQSDKDALFLQYQESLENLSKMETDLNKAQNNARGLD-DRASEAE 204
E EVQT+RE + + +++LE D++K + LD DR
Sbjct: 311 EKQNEVQTMREPVNASNRSFN------RQTLER-----GDISKTRLTKEWLDQDREEPVI 359
Query: 205 IQVEILKESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQK 264
++ + +S QLK+ D + + + ++ ++E++N ++ T ++++K
Sbjct: 360 LKQQRTVQSEFQLKSTPDLLRDQQPDGSDPTREMIFGILREGSLESENTLRKKTSILLEK 419
Query: 265 ----------DTVLL--QYKQCLEKIPMLENKIALAEENSRMLNDQIERTELEVETLRKN 312
DT+ L Q K+ K+ L+ ++ + L R + ++ L
Sbjct: 420 LPSLQVQPGEDTISLGSQKKELERKVAELQRQLDDEMKQRMKLETSQGRPKAGMQRLEIE 479
Query: 313 LAEMNEERDSLSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGML 372
L E EE L LY ++S M E++ V+ EQ++ K+ +KL S++ L
Sbjct: 480 LEESKEECSRLKELYEKKKNELSAMSQELMEVRMGKEQVETKLRTMEDKLMDSKEELSHL 539
Query: 373 E-------------KSNQNLQLEAENLVQRIASKDHELL-EKHTEIERLQTLMHGEHSNF 418
K + +Q E + ++Q I K ELL +K E+ L+ + E +N
Sbjct: 540 RAKGGTSPDKLALLKELEEVQDELDEVLQ-IRQKQEELLRQKDRELTALKGALKDEVANH 598
Query: 419 I--------QIESALQALQKLYSQSQKEQRNLALELKYGLLLLKDLELSKQDFKEEMQGI 470
Q ++ +Q L+K ++Q +L E + ++++L+ ++ +E
Sbjct: 599 DKDLDRVREQYQNDMQQLRKNMDNVSQDQLSLESERQKINQVVRNLQRELEESSDE---- 654
Query: 471 VEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKD-- 528
+ + K + + N RS K+ E+ ++K KE+ E E + + ++LQ E Q+K
Sbjct: 655 ISQWKEMFQKNKEELRSTKQ---ELLQMKLEKEESEDELKETRDRFSLLQSELAQVKKGS 711
Query: 529 ----DIQHLNERYQAMLEQLQSLGLNPNSFAASVRDLQNENFMLKETCKKEHS------- 577
++ + + Q + +QL+ L ++ +++ + E LK T K+E S
Sbjct: 712 VDPGEVASVRKELQRVQDQLKQLSVDKQKVEENLQQREREMSALKGTLKEEVSGRDRETV 771
Query: 578 ---------------EKEALREKSK----DMNEVLMENACMEFSLLGLNDELDGLRGTVK 618
E E L ++S+ + +VL+E E ++ EL L+G +K
Sbjct: 772 RLREQLQSEVMHVKKENEGLAKESRRIQDQLKQVLLEKQRHEETVHQRERELSVLKGALK 831
Query: 619 --------EIQQFCQVLQEEKSI--------------LADEKSTLLSQLQIITESMQKIL 656
E ++ + L+++ + L EK+ L Q+I ++Q+
Sbjct: 832 DEVSGRDRETEKLRERLEQDALMTKRSYEELVKINKRLESEKTDLERVRQVIENNLQESR 891
Query: 657 ENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLS 716
E N L + + + + + DL+ L D+ N L+ ER + E+ L
Sbjct: 892 EENDDLRRKILGLEAQLKETNTFCDDLQRAESRLKDKINKLEAERKRM-------EDSLG 944
Query: 717 NLEKKVTNLEEKYADVEKDKESAVNQVEELFASILVQKENHSNHKHSSEARLANLENIVR 776
+V + E++ A V++D ES +++ + + ++ E + +L+
Sbjct: 945 ----EVADQEQELAFVKRDLESKLDEAQRSLKRLSLEYEELQECYQEEMKQKDHLKKTKN 1000
Query: 777 VLQEEQRL---GKVEFEQELDRVVN-AQIEMFILQNCIEELELKNFVLLTECEKLVE--- 829
L+E++RL + +ELD + N ++ + +LQ +EE K+ + E +K +
Sbjct: 1001 ELEEQKRLLDKSMDKLTRELDNMSNESRGSLQLLQTQLEEYREKSRKEIGEAQKQAKEKT 1060
Query: 830 ---------ASKFSDKV------ISELESENLMQLIEEEFLLHRIRKFKMDIHKVCGVLQ 874
+S+ ++V + EL+ E ++++ + R++ + DI +
Sbjct: 1061 AEAERHQFNSSRMQEEVQKLKLALQELQVEKETVELDKQMISQRLQSLEQDIE---SKKR 1117
Query: 875 IDSDGGG-----DNEIKKEEIPISRILDKIESLESSLVKSQEENQQLLVENSVLLGSLQQ 929
+ D ++++K+ E + + +E L + +S+++ +Q E L Q
Sbjct: 1118 VQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLTDRVNRSRDQMEQQRAE-------LNQ 1170
Query: 930 HQSEGEKLKLEKKTVEQEFENMREQNVIL---QKDKVELLEENRQLRIEVVNGVEKENRS 986
+S G+ L+ +K ++E++ + ++ + + QK V + +L+ E+ ++ E R
Sbjct: 1171 ERSRGQDLECDKISLERQNKELKNRLASMEGQQKPSVNVSHLEAKLQ-EIQERLQLEERE 1229
Query: 987 KSTLAALQAEM-IELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDAKSSAEDE 1038
K+TL + ++ +L++ N ++E ++ D+K+ L V LK AE+E
Sbjct: 1230 KATLLSTNRKLERKLKELNIQLEDERLQVNDQKDQLNLRVKALKRQVDEAEEE 1282
Score = 102 bits (255), Expect = 7e-21
Identities = 186/958 (19%), Positives = 421/958 (43%), Gaps = 132/958 (13%)
Query: 398 LEKHTEI--ERLQTLMHGEHSNFIQIESALQALQKLYSQSQKEQRNLALELKYGLLLLKD 455
L K T I E+L +L + I + S + L++ ++ Q R L E+K +
Sbjct: 409 LRKKTSILLEKLPSLQVQPGEDTISLGSQKKELERKVAELQ---RQLDDEMKQRM----K 461
Query: 456 LELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKKQQMEISKLKEIKEKLEREFHTSTEE 515
LE S+ K MQ + E L++ + E S+LKE+ EK + E ++E
Sbjct: 462 LETSQGRPKAGMQRLEIE--------------LEESKEECSRLKELYEKKKNELSAMSQE 507
Query: 516 SNVLQRETHQIKDDIQHLNERYQAMLEQLQSL----GLNPNSFAASVRDLQNENFMLKET 571
++ Q++ ++ + ++ E+L L G +P+ A +++L+ L E
Sbjct: 508 LMEVRMGKEQVETKLRTMEDKLMDSKEELSHLRAKGGTSPDKLAL-LKELEEVQDELDEV 566
Query: 572 CKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDELDGLRGTVKEIQQFCQVLQEEK 631
+ ++E LR+K +++ + ++ + + +LD +R ++ Q Q L++
Sbjct: 567 LQIRQKQEELLRQKDRELTAL---KGALKDEVANHDKDLDRVR---EQYQNDMQQLRKNM 620
Query: 632 SILADEKSTLLSQLQIITE---SMQKILENNT--------VLEKS---LSDAKIEFEGLR 677
++ ++ +L S+ Q I + ++Q+ LE ++ + +K+ L K E ++
Sbjct: 621 DNVSQDQLSLESERQKINQVVRNLQRELEESSDEISQWKEMFQKNKEELRSTKQELLQMK 680
Query: 678 IKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLEKKVTNLEEKYADVEKDKE 737
++ + ED K D + LQ+E + + + + +++++ K++ ++++ + DK+
Sbjct: 681 LEKEESEDELKETRDRFSLLQSELAQ-VKKGSVDPGEVASVRKELQRVQDQLKQLSVDKQ 739
Query: 738 SAVNQVE----ELFASILVQKENHSNHKHSSEARLANLEN-IVRVLQEEQRLGKVEFEQE 792
++ E+ A KE S + L++ ++ V +E + L K
Sbjct: 740 KVEENLQQREREMSALKGTLKEEVSGRDRETVRLREQLQSEVMHVKKENEGLAKES---- 795
Query: 793 LDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVIS-ELESENLMQLIE 851
R + Q++ +L E+ + V E E V D+V + E+E L + +E
Sbjct: 796 --RRIQDQLKQVLL----EKQRHEETVHQRERELSVLKGALKDEVSGRDRETEKLRERLE 849
Query: 852 EEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQE 911
++ L+ + R ++ ++ K+ + ++ E+ + R+ IE+ +L +S+E
Sbjct: 850 QDALMTK-RSYE-ELVKI------------NKRLESEKTDLERVRQVIEN---NLQESRE 892
Query: 912 ENQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELLEENRQ 971
EN L + L L++ + + L+ + ++ + + + ++ E+ ++ ++
Sbjct: 893 ENDDLRRKILGLEAQLKETNTFCDDLQRAESRLKDKINKLEAERKRMEDSLGEVADQEQE 952
Query: 972 LRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVSDLKDA 1031
L + K + ++ +L L E EL++ +QEE + +K+ L + ++L++
Sbjct: 953 LAFVKRDLESKLDEAQRSLKRLSLEYEELQEC---YQEE----MKQKDHLKKTKNELEEQ 1005
Query: 1032 KSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGN-LSHLNNDLNQEFGV 1090
K + + ++ +SN E R + L L +E G
Sbjct: 1006 KRLLDKSMDKLTRELDNMSN--------------ESRGSLQLLQTQLEEYREKSRKEIGE 1051
Query: 1091 LRKNFEVKEAE-------NVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELKME 1143
+K + K AE + + E ++++ L E+ + E S+ ++ L+ +
Sbjct: 1052 AQKQAKEKTAEAERHQFNSSRMQEEVQKLKLALQELQVEKETVELDKQMISQRLQSLEQD 1111
Query: 1144 QEESTKIKENLDRQI------LEQSENCMNHKKE-IEHLNEANETLQFEMKTLLHEVEQH 1196
E +++++ RQ+ L++ E ++ +K +E L + + +M+ E+ Q
Sbjct: 1112 IESKKRVQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLTDRVNRSRDQMEQQRAELNQE 1171
Query: 1197 RVREEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDE- 1255
R R + L + ++ E + K +N A+ Q S+ ++ LE+K+ E+ ++ + E
Sbjct: 1172 RSRGQDLECDKISLERQNKELKNRLASM-EGQQKPSVNVSHLEAKLQEIQERLQLEEREK 1230
Query: 1256 ----SSAKSLENEHMREIISLLESE---IGGLKEQLSAYVPL----VSSLKEDFNSLE 1302
S+ + LE + ++E+ LE E + K+QL+ V V +E+ LE
Sbjct: 1231 ATLLSTNRKLERK-LKELNIQLEDERLQVNDQKDQLNLRVKALKRQVDEAEEEIERLE 1287
Score = 93.2 bits (230), Expect = 5e-18
Identities = 153/748 (20%), Positives = 285/748 (37%), Gaps = 106/748 (14%)
Query: 36 IDTKVKSMIKLIEEEADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHAMGELRH 95
I+ V+++ + +EE +D ++ EM+ K + EL +E + E D + E R
Sbjct: 637 INQVVRNLQRELEESSDEISQWKEMFQKNKEELRSTKQELLQMKLEKEESEDE-LKETRD 695
Query: 96 AHKTMPEAFPNSAYYILNDDSPCGSLGPDAESHTSARPTHRSKKNERSSEESNGEVQTLR 155
+ GS+ P GEV ++R
Sbjct: 696 RFSLLQSELAQVKK---------GSVDP-------------------------GEVASVR 721
Query: 156 EALAKMQSDKDALFLQYQESLENLSKMETDLN------KAQNNARGLDDRASEAEIQVEI 209
+ L ++Q L + Q+ ENL + E +++ K + + R + ++Q E+
Sbjct: 722 KELQRVQDQLKQLSVDKQKVEENLQQREREMSALKGTLKEEVSGRDRETVRLREQLQSEV 781
Query: 210 L---KESLMQLKADKDAGEVLYNQCLETIARLESMLSQKDNIEAKNLKQELTRVVVQKDT 266
+ KE+ K + + L LE R E + Q++ E LK L V +D
Sbjct: 782 MHVKKENEGLAKESRRIQDQLKQVLLEK-QRHEETVHQRER-ELSVLKGALKDEVSGRDR 839
Query: 267 VLLQYKQCLEKIPMLENKI--ALAEENSRMLNDQIERTELEV--ETLRKNLAEMNEERDS 322
+ ++ LE+ ++ + L + N R+ + E+T+LE + + NL E EE D
Sbjct: 840 ETEKLRERLEQDALMTKRSYEELVKINKRL---ESEKTDLERVRQVIENNLQESREENDD 896
Query: 323 LSVLYHHCLEKISKMENEILHVQENAEQLKNKIEKEAEKLEISEKHRGMLEKSNQNLQLE 382
L ++ + +Q +LK+KI K + + E G + Q L
Sbjct: 897 LRRKILGLEAQLKETNTFCDDLQRAESRLKDKINKLEAERKRMEDSLGEVADQEQELAFV 956
Query: 383 AENLVQRIASKDHELLEKHTEIERLQTLMHGE-------HSNFIQIESALQALQKLYSQS 435
+L ++ L E E LQ E ++E + L K +
Sbjct: 957 KRDLESKLDEAQRSLKRLSLEYEELQECYQEEMKQKDHLKKTKNELEEQKRLLDKSMDKL 1016
Query: 436 QKEQRNLALELKYGLLLLKDL-----ELSKQDFKEEMQGIVEENKTLHELNFSSTRSLKK 490
+E N++ E + L LL+ E S+++ E + E+ F+S+R
Sbjct: 1017 TRELDNMSNESRGSLQLLQTQLEEYREKSRKEIGEAQKQAKEKTAEAERHQFNSSR---- 1072
Query: 491 QQMEISKLKEIKEKLEREFHTSTEESNVLQRETHQIKDDIQHLNERYQAMLEQLQSLGLN 550
Q E+ KLK ++L+ E T + ++ + ++ DI+ Q++ L
Sbjct: 1073 MQEEVQKLKLALQELQVEKETVELDKQMISQRLQSLEQDIESKKRVQDDRSRQVKVLEDK 1132
Query: 551 PNSFAASVRDLQNENFMLKETCKKEHSEKEALREKSKDMNEVLMENACMEFSLLGLNDEL 610
A + + +N +L + + + E R + + C + SL N EL
Sbjct: 1133 LKRMEAELDEEKNTVELLTDRVNRSRDQMEQQRAELNQERSRGQDLECDKISLERQNKEL 1192
Query: 611 DGLRGT----------VKEIQQFCQVLQEEKSILADEKSTLLSQLQIITESMQKILENNT 660
+ V ++ Q +QE + EK+TLLS N
Sbjct: 1193 KNRLASMEGQQKPSVNVSHLEAKLQEIQERLQLEEREKATLLS--------------TNR 1238
Query: 661 VLEKSLSDAKIEFEGLRIKSGDLEDCCKLLNDEKNNLQNERSMLISQLEIVEEKLSNLE- 719
LE+ L + I+ E R++ +ND+K+ L L Q++ EE++ LE
Sbjct: 1239 KLERKLKELNIQLEDERLQ----------VNDQKDQLNLRVKALKRQVDEAEEEIERLEG 1288
Query: 720 --KKVTNLEEKYADVEKDKESAVNQVEE 745
KK E+ ++ + ++ V +E+
Sbjct: 1289 LRKKAVREMEEQQEINEQLQTRVKVMEK 1316
Score = 75.5 bits (184), Expect = 1e-12
Identities = 185/1028 (17%), Positives = 409/1028 (38%), Gaps = 149/1028 (14%)
Query: 630 EKSILADEKSTLLSQLQIITESMQKILENNTVLEKSLSDAKIEFEGLRIKSGDLEDCCKL 689
E+ ++ ++ T+ S+ Q+ +S +L + + SD E ++ G LE
Sbjct: 355 EEPVILKQQRTVQSEFQL--KSTPDLLRDQ---QPDGSDPTREMIFGILREGSLES---- 405
Query: 690 LNDEKNNLQNERSMLISQLEIVE----EKLSNLEKKVTNLEEKYADVEKDKESAVNQ--- 742
+N L+ + S+L+ +L ++ E +L + LE K A++++ + + Q
Sbjct: 406 ----ENTLRKKTSILLEKLPSLQVQPGEDTISLGSQKKELERKVAELQRQLDDEMKQRMK 461
Query: 743 -----------VEELFASILVQKENHSNHKHSSEARLANLENIVRVLQEEQRLGKVEFEQ 791
++ L + KE S K E + L + + L E R+GK + E
Sbjct: 462 LETSQGRPKAGMQRLEIELEESKEECSRLKELYEKKKNELSAMSQELMEV-RMGKEQVET 520
Query: 792 ELDRVVNAQIEMFILQNCIEELELKNFVLLTECEKLVEASKFSDKVISELESENLMQLIE 851
+L + + L + EEL T +KL + ++V EL+ ++ +
Sbjct: 521 KLRTMEDK------LMDSKEELSHLRAKGGTSPDKLALLKEL-EEVQDELDEVLQIRQKQ 573
Query: 852 EEFLLHRIRKFKMDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIESLESSLVKSQE 911
EE L + R ++ + G L+ +E+ + + R+ ++ ++ L K+ +
Sbjct: 574 EELLRQKDR----ELTALKGALK--------DEVANHDKDLDRVREQYQNDMQQLRKNMD 621
Query: 912 E--NQQLLVENSVLLGSLQQHQSEGEKLKLEKKTVEQEFENMREQNVILQKDKVELL--- 966
QL +E+ + Q + ++ ++ +E+ + + + + QK+K EL
Sbjct: 622 NVSQDQLSLES--------ERQKINQVVRNLQRELEESSDEISQWKEMFQKNKEELRSTK 673
Query: 967 EENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKNSLCRNVS 1026
+E Q+++E ++ ++ + LQ+E+ ++++ + + G++ + L R
Sbjct: 674 QELLQMKLEKEESEDELKETRDRFSLLQSELAQVKKGSV----DPGEVASVRKELQRVQD 729
Query: 1027 DLKDA---KSSAEDENSVMFHDVLALSNLNLVYEIFFT--ENMVEKRALCEHLGNLSHLN 1081
LK K E+ ++ AL L E+ E + + L + ++ N
Sbjct: 730 QLKQLSVDKQKVEENLQQREREMSALKG-TLKEEVSGRDRETVRLREQLQSEVMHVKKEN 788
Query: 1082 NDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEELK 1141
L +E ++ + E E++ + ++EL + LK +E+
Sbjct: 789 EGLAKESRRIQDQLKQVLLEKQRHEETVHQRERELSVLKGALK-------------DEVS 835
Query: 1142 MEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHRVREE 1201
E+ K++E L++ L + K + L L+ + + + +++ R +
Sbjct: 836 GRDRETEKLRERLEQDALMTKRSYEELVKINKRLESEKTDLERVRQVIENNLQESREEND 895
Query: 1202 ALNLELLNKENEFKLWENEAAAFYHDLQMSSICLALLESKVSELTGVCKILDDESSAKSL 1261
L ++L E + K E F DLQ + + L+ K+++L K ++D +
Sbjct: 896 DLRRKILGLEAQLK----ETNTFCDDLQRAE---SRLKDKINKLEAERKRMEDSLGEVAD 948
Query: 1262 ENEHM----REIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLEHISLLWTKRNSVVGN 1317
+ + + R++ S L+ LK Y L +E+ +H+ +N +
Sbjct: 949 QEQELAFVKRDLESKLDEAQRSLKRLSLEYEELQECYQEEMKQKDHLK---KTKNELEEQ 1005
Query: 1318 GAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAVEKIMMEEL---KRRV 1374
D ++ R+ + S L LQT++ + +E+ +++
Sbjct: 1006 KRLLDKSMDKLTRELDNMSNESR---------GSLQLLQTQLEEYREKSRKEIGEAQKQA 1056
Query: 1375 KQKSLTTESTPYSSLEIAT-YPKVENRKKEIELVEENVFDRNSWRKKPKIRLLMKDIPLD 1433
K+K+ E ++S + K++ +E+++ +E V + + +++ L +DI
Sbjct: 1057 KEKTAEAERHQFNSSRMQEEVQKLKLALQELQVEKETV-ELDKQMISQRLQSLEQDIESK 1115
Query: 1434 RNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAMICHRSDDSGRYLNYSSE 1493
+ V D S+ +K + EL E L V+ + R + + E
Sbjct: 1116 KRVQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLTDRVNRS----RDQMEQQRAELNQE 1171
Query: 1494 LDIEKELGVDKLELSKSVKE-------------------KTEDDKRRILERLSSDGQKLA 1534
++L DK+ L + KE E + I ERL + ++ A
Sbjct: 1172 RSRGQDLECDKISLERQNKELKNRLASMEGQQKPSVNVSHLEAKLQEIQERLQLEEREKA 1231
Query: 1535 ILKMALQDLKKKT-----ETKKKSKQGND------IEYETVKRHIEEVEEAVMQQVSIND 1583
L + L++K + + + Q ND + + +KR ++E EE + + +
Sbjct: 1232 TLLSTNRKLERKLKELNIQLEDERLQVNDQKDQLNLRVKALKRQVDEAEEEIERLEGLRK 1291
Query: 1584 QMAKNVEE 1591
+ + +EE
Sbjct: 1292 KAVREMEE 1299
Score = 63.5 bits (153), Expect = 5e-09
Identities = 161/861 (18%), Positives = 334/861 (38%), Gaps = 149/861 (17%)
Query: 788 EFEQELDRVVNAQIEMFILQNC----IEELELKNFVLLTECEKLVEASKFSDKVISELES 843
E +++LD + ++++ Q ++ LE++ EC +L E + +S +
Sbjct: 447 ELQRQLDDEMKQRMKLETSQGRPKAGMQRLEIELEESKEECSRLKELYEKKKNELSAMSQ 506
Query: 844 ENLMQLIEEEFLLHRIRKFK---MDIHKVCGVLQIDSDGGGDNEIKKEEIPISRILDKIE 900
E + + +E + ++R + MD + L+ D +E+ + D+++
Sbjct: 507 ELMEVRMGKEQVETKLRTMEDKLMDSKEELSHLRAKGGTSPDKLALLKEL--EEVQDELD 564
Query: 901 SLESSLVKSQEENQQLLVENSVLLGSLQQHQSEGEK-LKLEKKTVEQEFENMREQNVILQ 959
+ K +E +Q E + L G+L+ + +K L ++ + + + +R+ +
Sbjct: 565 EVLQIRQKQEELLRQKDRELTALKGALKDEVANHDKDLDRVREQYQNDMQQLRKNMDNVS 624
Query: 960 KDKVELLEENRQLRIEVVNGVEKENRSKSTLAALQAEMIELRQTNQVFQEENGKMLDEKN 1019
+D++ L E RQ +VV +++E L+ E+ Q ++FQ+ ++ K
Sbjct: 625 QDQLSL-ESERQKINQVVRNLQRE---------LEESSDEISQWKEMFQKNKEELRSTKQ 674
Query: 1020 SLCRNVSDLKDAKSSAEDENSVMFHDVLALSNLNLVYEIFFTENMVEKRALCEHLGNLSH 1079
L + +K K +EDE L E S
Sbjct: 675 ELLQ----MKLEKEESEDE-------------------------------LKETRDRFSL 699
Query: 1080 LNNDLNQEFGVLRKNFEVKEAENVYLNESIERMDKELLEMDKRLKAAETSNAEFSRHIEE 1139
L ++L Q K V E + + ++R+ +L ++ + E + + R +
Sbjct: 700 LQSELAQV-----KKGSVDPGEVASVRKELQRVQDQLKQLSVDKQKVEENLQQREREMSA 754
Query: 1140 LK--MEQEESTKIKENLDRQILEQSENCMNHKKEIEHLNEANETLQFEMKTLLHEVEQHR 1197
LK +++E S + +E + + QSE M+ KKE E L + + +Q ++K +L E ++H
Sbjct: 755 LKGTLKEEVSGRDRETVRLREQLQSE-VMHVKKENEGLAKESRRIQDQLKQVLLEKQRHE 813
Query: 1198 V----REEALNLELLNKENEFKLWENEAAAFYHDLQMSSICLAL-----------LESKV 1242
RE L++ ++E + E L+ ++ LES+
Sbjct: 814 ETVHQRERELSVLKGALKDEVSGRDRETEKLRERLEQDALMTKRSYEELVKINKRLESEK 873
Query: 1243 SELTGVCKILDDESSAKSLENEHMREIISLLESEIGGLKEQLSAYVPLVSSLKEDFNSLE 1302
++L V +++++ EN+ +R I LE+++ S LK+ N LE
Sbjct: 874 TDLERVRQVIENNLQESREENDDLRRKILGLEAQLKETNTFCDDLQRAESRLKDKINKLE 933
Query: 1303 HISLLWTKRNSVVGNGAQKDVVIETCLRKHSHQSARENEIVLIPDGVSDLLTLQTRIRAV 1362
+ + E+ + + D +L ++ + +
Sbjct: 934 ------------------------------AERKRMEDSLGEVADQEQELAFVKRDLES- 962
Query: 1363 EKIMMEELKRRVKQKSLTTESTPYSSLEIATYPKVENRKKEIELVEENVFDRNSWRKKPK 1422
++E +R +K+ SL E E++ + + KK K
Sbjct: 963 ---KLDEAQRSLKRLSLEYE--------------------ELQECYQEEMKQKDHLKKTK 999
Query: 1423 IRLLMKDIPLDRNVDDQNSKYLKREHRRTNDHVLELCENNEHEPLSAPTVDHAM--ICHR 1480
L + LD+++D + + L + E+ S + A +
Sbjct: 1000 NELEEQKRLLDKSMDKLTRELDNMSNESRGSLQLLQTQLEEYREKSRKEIGEAQKQAKEK 1059
Query: 1481 SDDSGRYLNYSSELDIEKELGVDKLELS----KSVKEKTEDDKRRILERLSSDGQKLAIL 1536
+ ++ R+ SS + E V KL+L+ + KE E DK+ I +RL S Q +
Sbjct: 1060 TAEAERHQFNSSRMQEE----VQKLKLALQELQVEKETVELDKQMISQRLQSLEQDIESK 1115
Query: 1537 KMALQDLKKKTETKKKSKQGNDIEYETVKRHIEEVEEAVMQQVSINDQMAKNVEEGASSL 1596
K D ++ + + + + E + K +E + + V + DQM E+ + L
Sbjct: 1116 KRVQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLTDRVNRS---RDQM----EQQRAEL 1168
Query: 1597 DREIPRRGSEQIGKLQFEVQN 1617
++E R + K+ E QN
Sbjct: 1169 NQERSRGQDLECDKISLERQN 1189
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.310 0.128 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 174,417,423
Number of Sequences: 164201
Number of extensions: 7436015
Number of successful extensions: 55703
Number of sequences better than 10.0: 1905
Number of HSP's better than 10.0 without gapping: 436
Number of HSP's successfully gapped in prelim test: 1486
Number of HSP's that attempted gapping in prelim test: 32810
Number of HSP's gapped (non-prelim): 10496
length of query: 1662
length of database: 59,974,054
effective HSP length: 124
effective length of query: 1538
effective length of database: 39,613,130
effective search space: 60924993940
effective search space used: 60924993940
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 73 (32.7 bits)
Medicago: description of AC135320.2