BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC131240.9 - phase: 0
(430 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CP72_CATRO (Q05047) Cytochrome P450 72A1 (EC 1.3.3.9) (CYPLXXII)... 258 2e-68
YRVA_CAEEL (Q27519) Putative cytochrome P450 CYP13A7 (EC 1.14.-.-) 174 3e-43
YRV7_CAEEL (Q27518) Putative cytochrome P450 CYP13A2 (EC 1.14.-.-) 168 2e-41
YRV8_CAEEL (Q27520) Putative cytochrome P450 CYP13A1 (EC 1.14.-.-) 167 4e-41
YRV2_CAEEL (Q27514) Putative cytochrome P450 CYP13A5 (EC 1.14.-.-) 166 8e-41
YRV1_CAEEL (Q27513) Putative cytochrome P450 CYP13A4 (EC 1.14.-.-) 162 2e-39
CP3B_MOUSE (Q64459) Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA... 158 3e-38
C4X1_HUMAN (Q8N118) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)... 157 4e-38
C341_MOUSE (Q9JMA7) Cytochrome P450 3A41 (EC 1.14.14.1) 156 1e-37
CPFB_HUMAN (Q9HBI6) Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11) 155 1e-37
CP32_RAT (P05183) Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) ... 155 1e-37
C4Z1_HUMAN (Q86W10) Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1)... 155 1e-37
C4X1_RAT (Q8K4D6) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1) 154 3e-37
CP44_RABIT (P10611) Cytochrome P450 4A4 precursor (EC 1.14.14.1)... 154 5e-37
YS24_CAEEL (Q09653) Putative cytochrome P450 CYP13A10 (EC 1.14.-.-) 153 7e-37
CPF8_HUMAN (P98187) Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) 153 7e-37
CP43_RAT (P20817) Cytochrome P450 4A3 precursor (EC 1.14.15.3) (... 153 7e-37
CPF2_HUMAN (P78329) Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2... 152 2e-36
YRV3_CAEEL (Q27515) Putative cytochrome P450 CYP13A6 (EC 1.14.-.-) 150 5e-36
CP4B_RAT (P15129) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (... 150 5e-36
>CP72_CATRO (Q05047) Cytochrome P450 72A1 (EC 1.3.3.9) (CYPLXXII)
(Secologanin synthase) (SLS)
Length = 524
Score = 258 bits (659), Expect = 2e-68
Identities = 135/429 (31%), Positives = 233/429 (53%), Gaps = 10/429 (2%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDW 68
G+ W+G P +++ E +K++ T + ++ K N +G+ EG W
Sbjct: 96 GRNSFTWMGRIPRIHVMEPELIKEVLTH--SSKYQKNFDVHNPLVKFLLTGVGSFEGAKW 153
Query: 69 VRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINF-GNHEIDMEKEIITIAGEII 127
+HR I++PAF LK M + M+ +W G+HE+D+ + ++I
Sbjct: 154 SKHRRIISPAFTLEKLKSMLPAFAICYHDMLTKWEKIAEKQGSHEVDIFPTFDVLTSDVI 213
Query: 128 AKTSFGAEDENAKEVFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLEAKKLGKEIDKLL 187
+K +FG+ E ++F L+ L + R V +P Y K+N K++ KEI +L
Sbjct: 214 SKVAFGSTYEEGGKIFRLLKELMDLTIDCMRDVYIPGWSYLPTKRNKRMKEINKEITDML 273
Query: 188 LSIVEARKNSPK--QNSQKDLLGLLLKENNED-----GKLGKTLTSREVVDECKTFFFGG 240
I+ R + K + + DLLG+LL+ N ++ K ++ +V++ECK F+F G
Sbjct: 274 RFIINKRMKALKAGEPGEDDLLGVLLESNIQEIQKQGNKKDGGMSINDVIEECKLFYFAG 333
Query: 241 HETTALAITWTLLLLATHEDWQNQLREEIKEVVGNNELDITMLSGLKKMKCVMNEVLRLY 300
ETT + +TWT +LL+ H +WQ + REE+ + G N+ + L+ LK + ++ EVLRLY
Sbjct: 334 QETTGVLLTWTTILLSKHPEWQERAREEVLQAFGKNKPEFERLNHLKYVSMILYEVLRLY 393
Query: 301 PPAPNVQRQAREDIQVDDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPERFMDDVNGG 360
PP ++ + +D ++ T+P GT + + V +H + +WG+D EF P RF+D V
Sbjct: 394 PPVIDLTKIVHKDTKLGSYTIPAGTQVMLPTVMLHREKSIWGEDAMEFNPMRFVDGVANA 453
Query: 361 CKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSYQHSPAIMLSLRPAH 420
K+ + YLPF +G R+C+G+N ++ K+ L ++L F F V+PSY H+P +L+++P
Sbjct: 454 TKNNVTYLPFSWGPRVCLGQNFALLQAKLGLAMILQRFKFDVAPSYVHAPFTILTVQPQF 513
Query: 421 GLPLIVQPL 429
G +I + L
Sbjct: 514 GSHVIYKKL 522
>YRVA_CAEEL (Q27519) Putative cytochrome P450 CYP13A7 (EC 1.14.-.-)
Length = 518
Score = 174 bits (442), Expect = 3e-43
Identities = 126/429 (29%), Positives = 213/429 (49%), Gaps = 35/429 (8%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
G V+ G E L I++ EF+ ++ + +G K + + D + LV +G+
Sbjct: 65 GPVYGITEGVEKTLVISDPEFVHEVFVKQFDNFYGRKLTAIQGDPNKNKRVPLVAAQGHR 124
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R + +P F+ +L+ + + ES +++ R + + +DM + +II
Sbjct: 125 WKRLRTLASPTFSNKSLRKIMGTVEESVTELV-RSLEKASAEGKTLDMLEYYQEFTMDII 183
Query: 128 AKTSFGAED---------ENAKEVFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLE-AK 177
K + G E + K +F + R + +VG+ F +L+ A
Sbjct: 184 GKMAMGQEKSLMFRNPMLDKVKTIFKEGRNNVFMISGIFPFVGIALRNIFAKFPSLQMAT 243
Query: 178 KLGKEIDKLLLSIVEARKNSPKQNSQ-----KDLLGLLLKENN----------------E 216
+ ++K L +E R+ K + +D + L L + E
Sbjct: 244 DIQSILEKALNKRLEQREADEKAGIEPSGEPQDFIDLFLDARSTVDFFEGEAEQDFAKSE 303
Query: 217 DGKLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNN 276
K+ K LT E++ + F G++TTAL+++++ LLATH + Q +L+EE+ +
Sbjct: 304 VLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEEVDRECPDP 363
Query: 277 ELDITMLSGLKKMKCVMNEVLRLYPPAPNV-QRQAREDIQVDDVTVPNGTNMWIDVVAMH 335
E+ LS LK ++CV+ E LRLYP A V R+ + V + + GTN+ +D ++H
Sbjct: 364 EVTFDQLSKLKYLECVVKEALRLYPLASLVHNRKCLKTTNVLGMEIEAGTNINVDTWSLH 423
Query: 336 HDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILL 395
HDP++WGDDVNEFKPER+ + + K GYLPFG G R+C+G L ME K++LT +L
Sbjct: 424 HDPKVWGDDVNEFKPERW-ESGDELFFAKGGYLPFGMGPRICIGMRLAMMEMKMLLTNIL 482
Query: 396 SNFTFKVSP 404
N+TF+ +P
Sbjct: 483 KNYTFETTP 491
>YRV7_CAEEL (Q27518) Putative cytochrome P450 CYP13A2 (EC 1.14.-.-)
Length = 515
Score = 168 bits (426), Expect = 2e-41
Identities = 122/431 (28%), Positives = 207/431 (47%), Gaps = 51/431 (11%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
GKV+ Y GT+ L +A+ + ++ + +G K + + + + L+ +G
Sbjct: 67 GKVYGYTDGTQRTLVVADPAMVHEIFVKQFDNFYGRKLNPIQGNPEKEQRVHLLAAQGYR 126
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R I + +F+ +LK M + +S +++ R + G +IDM + ++I
Sbjct: 127 WKRLRTISSQSFSNASLKKMKRTVEDSALELL-RHIEKQTAGGEQIDMLRFYQEYTMDVI 185
Query: 128 AKTSFGAEDEN---------AKEVFDKLRALQMTLFN------------TNRYVGVPFGK 166
+ + G D +E+F R M + T ++ +P K
Sbjct: 186 GRFAMGQTDSMMFKNPIVNVVREIFCGSRKNLMLICQVFPPIGQFIRDLTFKFPRIPAFK 245
Query: 167 YFNVKKNLEAKKLGKEIDKLLLSIVEARKNSPKQNSQKDLLGLLLKENNEDG-------- 218
+++ +++ A ++ + R+ + +D + L L ++D
Sbjct: 246 LYSIMQDVVAARIAQR----------EREKGAESGEPQDFIDLFLDARSDDVDFSAEARE 295
Query: 219 -------KLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKE 271
K+ K L++ EVV +C F GG +TTAL++++ LLA + Q ++ EEI
Sbjct: 296 DFSKRNLKITKELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAR 355
Query: 272 VVGNNELDITMLSGLKKMKCVMNEVLRLYPPAP-NVQRQAREDIQVDDVTVPNGTNMWID 330
G +E++ L LK M CV+ E LRLYP A + R+ + V+ V + G + +D
Sbjct: 356 EFGTSEVEFEKLGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMD 415
Query: 331 VVAMHHDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIV 390
++H+DPELWG+DV EFKPER+ D +HK YLPFG G R C+G L ME KI+
Sbjct: 416 TWSLHYDPELWGEDVKEFKPERWSTD--EPLEHKGAYLPFGLGPRQCIGMRLAIMEQKIL 473
Query: 391 LTILLSNFTFK 401
LT LL N+TF+
Sbjct: 474 LTHLLKNYTFE 484
>YRV8_CAEEL (Q27520) Putative cytochrome P450 CYP13A1 (EC 1.14.-.-)
Length = 519
Score = 167 bits (424), Expect = 4e-41
Identities = 124/428 (28%), Positives = 201/428 (45%), Gaps = 39/428 (9%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
GK++ + GT L I++ E + ++ +G K + + D + + L +G
Sbjct: 66 GKIYGFTEGTLKTLVISDPELVHEVFVTQYDNFYGRKRNPIQGDSEKEKRTNLFAAQGFR 125
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R I +P F+ +L+ + + +S +++ R + + G +IDM K ++I
Sbjct: 126 WKRLRAISSPTFSNSSLRKLYQTVEDSALELL-RHIEKQSAGGKQIDMLKFYQEFTLDVI 184
Query: 128 AKTSFGAEDENAKEVFDKLRALQMTLFNTNRYVGVPFGKYFN----------VKKNLEAK 177
+ + G D + + + + LF N G F + KNL+
Sbjct: 185 GRIAMGQTDSQMFK--NPIMPIVSKLFQGNFAKLFLIGGIFPTFLVEIIRQILLKNLKVG 242
Query: 178 KLGKEIDKLLLSIV--------EARKNSPKQNSQKDLLGLLLK----------ENNEDGK 219
K I+++ L + E +KN + D + L L ENN D
Sbjct: 243 SFRK-INEITLDAIHNRIKQREEDQKNGIEIGEPADFIDLFLDAKAEDVEHFGENNGDFS 301
Query: 220 LGKTLTSR-----EVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVG 274
T T+R E+V +C F G +TTAL++++ LLATH + Q +L+EE+
Sbjct: 302 KSTTYTNRQLTTEEIVGQCTVFLIAGFDTTALSLSYATYLLATHPEIQKKLQEEVNRECP 361
Query: 275 NNELDITMLSGLKKMKCVMNEVLRLYPPAPNVQ-RQAREDIQVDDVTVPNGTNMWIDVVA 333
N E+ I LS LK M+CV E LRLYP R+ + ++ ++ V GT + +D
Sbjct: 362 NPEVTIDQLSKLKYMECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWT 421
Query: 334 MHHDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTI 393
+H DP +WGDD +FKPER+ + K GY+PFG G R C+G L +ME KI+L
Sbjct: 422 LHTDPNIWGDDAEDFKPERWQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVH 481
Query: 394 LLSNFTFK 401
+L FTF+
Sbjct: 482 ILRKFTFE 489
>YRV2_CAEEL (Q27514) Putative cytochrome P450 CYP13A5 (EC 1.14.-.-)
Length = 520
Score = 166 bits (421), Expect = 8e-41
Identities = 125/456 (27%), Positives = 216/456 (46%), Gaps = 46/456 (10%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
G ++ G E L ++N EF+ ++ + +G K + + D + + LV +G+
Sbjct: 65 GPIYGITEGVEKTLIVSNPEFVHEVFVKQFDNFYGRKTNPIQGDPNKNKRAHLVSAQGHR 124
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R + +P F+ NL+ + S + E+ +++ R + +D+ +II
Sbjct: 125 WKRLRTLSSPTFSNKNLRKIMSTVEETVVELM-RHLDDASAKGKAVDLLDYYQEFTLDII 183
Query: 128 AKTSFGAEDE---------NAKEVFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLE-AK 177
+ + G + K +F R L + G F ++F +++ A
Sbjct: 184 GRIAMGQTESLMFRNPMLPKVKGIFKDGRKLPFLVSGIFPIAGTMFREFFMRFPSIQPAF 243
Query: 178 KLGKEIDKLLLSIVEARKNSPKQNSQ-----KDLLGLLLKEN----------------NE 216
+ ++K L +E R K + +D + L L E
Sbjct: 244 DIMSTVEKALNKRLEQRAADEKAGIEPSGEPQDFIDLFLDARANVDFFEEESALGFAKTE 303
Query: 217 DGKLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNN 276
K+ K LT E++ + F G++TTAL+++++ LLA H + Q +L+EE+ N
Sbjct: 304 IAKVDKQLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLARHPEIQKKLQEEVDRECPNP 363
Query: 277 ELDITMLSGLKKMKCVMNEVLRLYPPAPNV-QRQAREDIQVDDVTVPNGTNMWIDVVAMH 335
E+ +S LK M+CV+ E LR+YP A V R+ ++ V V + GTN+ +D +H
Sbjct: 364 EVTFDQISKLKYMECVVKEALRMYPLASIVHNRKCMKETNVLGVQIEKGTNVQVDTWTLH 423
Query: 336 HDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILL 395
+DP++WG+D NEF+PER+ + + K GYLPFG G R+C+G L ME K++LT +L
Sbjct: 424 YDPKVWGEDANEFRPERW-ESGDELFYAKGGYLPFGMGPRICIGMRLAMMEKKMLLTHIL 482
Query: 396 SNFTFKVSP----------SYQHSP-AIMLSLRPAH 420
+TF+ S S +P ++ML L P H
Sbjct: 483 KKYTFETSTQTEIPLKLVGSATTAPRSVMLKLTPRH 518
>YRV1_CAEEL (Q27513) Putative cytochrome P450 CYP13A4 (EC 1.14.-.-)
Length = 520
Score = 162 bits (410), Expect = 2e-39
Identities = 117/432 (27%), Positives = 204/432 (47%), Gaps = 43/432 (9%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
G ++ G E L ++N EF+ ++ + +G K + + D + + LV+ +G+
Sbjct: 65 GSIYGITEGVEKTLVVSNPEFVHEVFVKQFDNFYGRKTNPIQGDPNKNKRAHLVLAQGHR 124
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R + +P F+ +L+ + S + E+ +++ R + + +D+ +II
Sbjct: 125 WKRLRTLASPTFSNKSLRKIMSTVEETVVELM-RHLDEASAKGKAVDLLDYYQEFTLDII 183
Query: 128 AKTSFGAEDE---------NAKEVFDKLRALQMTLFNTNRYVGV----------PFGKYF 168
+ + G + KE+F K + + G F F
Sbjct: 184 GRIAMGQTESLMFRNPMLPKVKEIFKKGGKMPFLIAGVFPIAGTLMRQLFMKFPKFSPAF 243
Query: 169 NVKKNLEAKKLGKEIDKLLLSIVEARKNSPKQNSQKDLLGLLLKEN------NEDGKLG- 221
+ +E K L K +++ + + +D + L L E+ LG
Sbjct: 244 GIMNTME-KALNKRLEQ---RAADKKAGIEPSGEPQDFIDLFLDARANVDFIEEESTLGF 299
Query: 222 ---------KTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEV 272
K LT E++ + F G++TTAL+++++ LLATH + Q +L+EE+
Sbjct: 300 AKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEEVDRE 359
Query: 273 VGNNELDITMLSGLKKMKCVMNEVLRLYPPAPNV-QRQAREDIQVDDVTVPNGTNMWIDV 331
+ E+ +S LK M+CV+ E LR+YP A V R+ + V V + GTN+ +D
Sbjct: 360 CPDPEVTFDQISKLKYMECVVKEALRMYPLASLVHNRKCMKKTNVLGVEIDEGTNVQVDT 419
Query: 332 VAMHHDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVL 391
+H+DP++WGDD +EFKPER+ + + K GYLPFG G R+C+G L ME K++L
Sbjct: 420 WTLHYDPKVWGDDASEFKPERW-ETGDELFYAKGGYLPFGMGPRICIGMRLAMMEEKLLL 478
Query: 392 TILLSNFTFKVS 403
T +L +TF S
Sbjct: 479 THILKKYTFDTS 490
>CP3B_MOUSE (Q64459) Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11)
(P-450IIIAM1) (P-450UT)
Length = 504
Score = 158 bits (399), Expect = 3e-38
Identities = 117/410 (28%), Positives = 198/410 (47%), Gaps = 28/410 (6%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRD----PMFGSGLVMVE 64
GK + + G P L + + E +K + + SVF N RD + + + +
Sbjct: 69 GKTWGLFDGQTPLLAVTDPETIKNVLVKECF------SVFTNRRDFGPVGIMSKAISISK 122
Query: 65 GNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAG 124
++W R+R +++P F LK M + IE ++ ++ Q + M+ + +
Sbjct: 123 DDEWKRYRALLSPTFTSGKLKEMFPV-IEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSM 181
Query: 125 EIIAKTSFGAEDENAKEVFDKL-----RALQMTLFNTNRYVGVPFGKYFNVKKNLEAKKL 179
++I TSFG ++ D + L+ F+ + V F V + L
Sbjct: 182 DVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMF 241
Query: 180 GKEIDKLLLSIVEARKNSPKQNSQK---DLLGLLLKENN--EDGKLGKTLTSREVVDECK 234
K+ + V+ K S + QK D L L++ +N +D K L+ E+ +
Sbjct: 242 PKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSI 301
Query: 235 TFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNNE---LDITMLSGLKKMKC 291
F F G+ETT+ +++TL LATH D Q +L++EI E + N D M ++ +
Sbjct: 302 IFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVM--EMEYLDM 359
Query: 292 VMNEVLRLYPPAPNVQRQAREDIQVDDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPE 351
V+NE LRLYP A ++R ++D++++ V +P G+ + I A+HHDP+ W + EF+PE
Sbjct: 360 VLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEP-EEFQPE 418
Query: 352 RFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFK 401
RF + N G YLPFG G R C+G M K+ LT ++ NF+F+
Sbjct: 419 RFSKE-NKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQ 467
>C4X1_HUMAN (Q8N118) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)
(UNQ1929/PRO4404)
Length = 509
Score = 157 bits (398), Expect = 4e-38
Identities = 107/443 (24%), Positives = 210/443 (47%), Gaps = 35/443 (7%)
Query: 10 KVFIYWLGT-EPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDW 68
+ F +W+G + F I + ++ K + +++ K + P+ G GL ++G W
Sbjct: 78 RAFPFWIGPFQAFFCIYDPDYAKTL----LSRTDPKSQYLQKFSPPLLGKGLAALDGPKW 133
Query: 69 VRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIA 128
+HR ++ P F+ LK +M S M+D+W + + +++ + I +++ +II
Sbjct: 134 FQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193
Query: 129 KTSFGAE---------DENAKEVFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLEAKKL 179
K +F E D AK +F+ + + L++ + + F + +KL
Sbjct: 194 KCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL---SPQGYRFQKL 250
Query: 180 GKEIDKLLLSIVEARK----------NSPKQNSQKDLLGLLLKENNEDGKLGKTLTSREV 229
+ +++ +I++ RK N+PK+ Q D L ++L +E G + + +V
Sbjct: 251 SRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQ-DFLDIVLSAKDES---GSSFSDIDV 306
Query: 230 VDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGN-NELDITMLSGLKK 288
E TF GH+T A +I+W L LA + + Q + REE++ ++G+ + + L +
Sbjct: 307 HSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSY 366
Query: 289 MKCVMNEVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHHDPELWGDDVNE 347
+ E RL P P++ R + + D T+P G + + + +HH+P +W +
Sbjct: 367 TTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KNPKV 425
Query: 348 FKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSYQ 407
F P RF + N +H YLPF G R C+G+ +E K+ + ++L +F P+
Sbjct: 426 FDPLRFSQE-NSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRP 484
Query: 408 HSPAIMLSLRPAHGLPLIVQPLN 430
+ L+P +G+ L ++ L+
Sbjct: 485 LTFPNHFILKPKNGMYLHLKKLS 507
>C341_MOUSE (Q9JMA7) Cytochrome P450 3A41 (EC 1.14.14.1)
Length = 504
Score = 156 bits (394), Expect = 1e-37
Identities = 118/410 (28%), Positives = 200/410 (48%), Gaps = 28/410 (6%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRD----PMFGSGLVMVE 64
GK + + G P I + E +K + + SVF N R+ + + + +
Sbjct: 69 GKTWGLFDGQMPLFVITDPEMIKNVLVKECF------SVFTNRREFGPVGIMSKAISISK 122
Query: 65 GNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAG 124
+W R+R +++P F LK M + IE ++ ++ Q + M+ + +
Sbjct: 123 DEEWKRYRALLSPTFTSGKLKEMFPV-IEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSI 181
Query: 125 EIIAKTSFGAEDE---NAKEVF-DKLRA-LQMTLFNTNRYVGVPFGKYFNVKKNLEAKKL 179
++I TSFG + N ++ F +K + L++ F+ + V F V + L
Sbjct: 182 DVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMF 241
Query: 180 GKEIDKLLLSIVEARKNSPKQNSQK---DLLGLLLK--ENNEDGKLGKTLTSREVVDECK 234
K+ + V K S + QK D L L++ N++D K L+ E+ +
Sbjct: 242 PKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSI 301
Query: 235 TFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNNE---LDITMLSGLKKMKC 291
F F G+ETT+ +++TL LATH D Q +L+EEI E + N D M ++ +
Sbjct: 302 VFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVM--EMEYLDM 359
Query: 292 VMNEVLRLYPPAPNVQRQAREDIQVDDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPE 351
V+NE LRLYP ++R ++D++++ V +P G+ + I A+HHDP+ W + EF+PE
Sbjct: 360 VLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHW-PEPEEFQPE 418
Query: 352 RFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFK 401
RF + N G Y+PFG G R C+G FM K+ LT ++ NF+F+
Sbjct: 419 RFSKE-NKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQ 467
>CPFB_HUMAN (Q9HBI6) Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)
Length = 524
Score = 155 bits (393), Expect = 1e-37
Identities = 126/444 (28%), Positives = 211/444 (47%), Gaps = 38/444 (8%)
Query: 12 FIYWLG-TEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDWVR 70
F WLG T P L + + + ++ + T A K +F P G GL++ G+ W R
Sbjct: 88 FKLWLGPTFPLLILCHPDIIRPI-TSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR 146
Query: 71 HRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIAKT 130
HR ++ PAF+ LK + +S N M D+W + G+ +DM + I + + + K
Sbjct: 147 HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKC 206
Query: 131 SFGAEDENAKE-------------VFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLEAK 177
F E N +E F + R Q+ L Y P G+ F +L
Sbjct: 207 VFSFES-NCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHD 265
Query: 178 KLGKEIDKLLLS-----IVEARKNSPKQNSQKDLLGLLLKENNEDGKLGKTLTSREVVDE 232
I + + I + KN K + D + +LL +EDGK L+ ++ E
Sbjct: 266 FTDAVIQERRRTLPTQGIDDFLKNKAKSKTL-DFIDVLLLSKDEDGK---ELSDEDIRAE 321
Query: 233 CKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNN---ELDITMLSGLKKM 289
TF F GH+TTA ++W L LA H ++Q Q R+E++E++ + E++ L+ L +
Sbjct: 322 ADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFL 381
Query: 290 KCVMNEVLRLYPPAPNVQRQARED-IQVDDVTVPNGTNMWIDVVAMHHDPELWGDDVNEF 348
+ E LRL+PP P + R +D + D +P G I+++ +H++P +W D +
Sbjct: 382 TMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW-PDPEVY 440
Query: 349 KPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSY-- 406
P RF + N + + ++PF G R C+G+ E K+VL + L + F++ P++
Sbjct: 441 DPFRFNQE-NIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLH--FRILPTHTE 497
Query: 407 -QHSPAIMLSLRPAHGLPLIVQPL 429
+ P ++ LR GL L V+PL
Sbjct: 498 PRRKPELI--LRAEGGLWLRVEPL 519
>CP32_RAT (P05183) Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2)
(P450-PCN2) (P450/6-beta-A) (Testosterone
6-beta-hydroxylase)
Length = 504
Score = 155 bits (393), Expect = 1e-37
Identities = 122/411 (29%), Positives = 199/411 (47%), Gaps = 30/411 (7%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRD----PMFGSGLVMVE 64
GK++ + G P I + E +K + + SVF N RD + G + + +
Sbjct: 69 GKIWGLFDGQTPVFAIMDTEMIKNVLVKECF------SVFTNRRDFGPVGIMGKAVSVAK 122
Query: 65 GNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAG 124
+W R+R +++P F LK M + IE ++ ++ Q + M+K +
Sbjct: 123 DEEWKRYRALLSPTFTSGRLKEMFPI-IEQYGDILVKYLKQEAETGKPVTMKKVFGAYSM 181
Query: 125 EIIAKTSFGAEDE---NAKEVF-DKLRALQMTLFNTNRYVGVPFGKYFN-VKKNLEAKKL 179
++I TSFG + N K+ F +K + L F ++ V + + + L
Sbjct: 182 DVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMF 241
Query: 180 GKE----IDKLLLSIVEARKNSPKQNSQKDLLGLLLK--ENNEDGKLGKTLTSREVVDEC 233
K+ K + I E R +S K + D L L+L N++D K L+ E++ +
Sbjct: 242 PKDSIAFFQKFVHRIKETRLDS-KHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQS 300
Query: 234 KTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNNE---LDITMLSGLKKMK 290
F F G+ETT+ +++ L LATH D Q +L+EEI + + DI M ++ +
Sbjct: 301 VIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVM--EMEYLD 358
Query: 291 CVMNEVLRLYPPAPNVQRQAREDIQVDDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKP 350
V+NE LRLYP ++R ++DI++D + +P G+ + I A+HHDP+ W EF P
Sbjct: 359 MVLNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHW-PKPEEFHP 417
Query: 351 ERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFK 401
ERF + N G YLPFG G R C+G M K+ LT +L NF+F+
Sbjct: 418 ERFSKE-NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQ 467
>C4Z1_HUMAN (Q86W10) Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1)
(UNQ3060/PRO9882)
Length = 505
Score = 155 bits (393), Expect = 1e-37
Identities = 110/391 (28%), Positives = 189/391 (48%), Gaps = 40/391 (10%)
Query: 44 KPSVFRNDRDPMFGSGLVMVEGNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWT 103
K +V + G GLV ++G+ W +HR IV P FN LK+ +MM ES M+++W
Sbjct: 109 KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWE 168
Query: 104 SQINFGNHEIDMEKEIITIAGEIIAKTSFGAE---------DENAKEVFDKLRALQMTLF 154
I N +++ + + + + I K +F + D K VF+ + +
Sbjct: 169 EHI-AQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMN 227
Query: 155 NTNRYVGVPF-----GKYFNVKKNLEAKKLGKEIDKLLLSIVEARKNSPK--------QN 201
N + + F G+ F+ K +E+ + +++ RK S K Q
Sbjct: 228 NFLHHNDLVFKFSSQGQIFS--------KFNQELHQFTEKVIQDRKESLKDKLKQDTTQK 279
Query: 202 SQKDLLGLLLKENNEDGKLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDW 261
+ D L +LL +E+ K + ++ E KTF F GH+TT+ AI+W L LA + +
Sbjct: 280 RRWDFLDILLSAKSEN---TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEH 336
Query: 262 QNQLREEIKEVVGN-NELDITMLSGLKKMKCVMNEVLRLYPPAPNVQRQAREDIQV-DDV 319
Q + R+EI+E++G+ + + LS + + E LRLY P N+ R + I D
Sbjct: 337 QQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR 396
Query: 320 TVPNGTNMWIDVVAMHHDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVG 379
++P G ++I++ A+HH+P W +D F P RF + N H ++PF G R C+G
Sbjct: 397 SLPAGITVFINIWALHHNPYFW-EDPQVFNPLRFSRE-NSEKIHPYAFIPFSAGLRNCIG 454
Query: 380 RNLTFMEYKIVLTILLSNFTFKVSPSYQHSP 410
++ +E K+ + + L FK++P + P
Sbjct: 455 QHFAIIECKVAVALTL--LRFKLAPDHSRPP 483
>C4X1_RAT (Q8K4D6) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)
Length = 507
Score = 154 bits (390), Expect = 3e-37
Identities = 116/444 (26%), Positives = 202/444 (45%), Gaps = 45/444 (10%)
Query: 12 FIYWLGT-EPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDWVR 70
F W+G + F YI + ++ K +++ K P G GL+ ++G W +
Sbjct: 80 FPCWVGPFQAFFYIYDPDYAKIF----LSRTDPKTQYLHQLMTPFLGRGLLNLDGPRWFQ 135
Query: 71 HRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIAKT 130
HR ++ PAF+ LK MM S N M+D+W I++ + I + +II K
Sbjct: 136 HRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKC 195
Query: 131 SFGAE---------DENAKEVFDKLRALQMTLFNTNRYVGVPFGKYFNVKKNLEAK---- 177
+FG E + K F+ + L+N F + ++ L K
Sbjct: 196 AFGQETNCQINGTYESYVKATFELGEIISSRLYN--------FWHHHDIIFKLSPKGHCF 247
Query: 178 -KLGKEIDKLLLSIVEARKNSPKQNSQKD-------LLGLLLKENNEDGKLGKTLTSREV 229
+LGK I + I++ RK + K +D L ++L D K + ++
Sbjct: 248 QELGKVIHQCTEKIIQDRKKTLKDQVNQDDTQTSQNFLDIVLSAQAGD---EKAFSDADL 304
Query: 230 VDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGN-NELDITMLSGLKK 288
E TF + GH+ +A +I+W L LA + + Q++ R EI+ ++G+ + + L +
Sbjct: 305 RSEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEIPY 364
Query: 289 MKCVMNEVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHHDPELWGDDVNE 347
+ E LRL PP P++ R+ + + + D ++P G + + + +HH+P +W D
Sbjct: 365 TTMCIKETLRLIPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVW-KDPKV 423
Query: 348 FKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSYQ 407
F P RF + N +H +LPF G R C+G+ +E K+ + + L F+V+
Sbjct: 424 FDPLRFTKE-NSEQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTL--LRFRVAADLT 480
Query: 408 HSPAIM--LSLRPAHGLPLIVQPL 429
PA LRP HG+ L ++ L
Sbjct: 481 RPPAFSSHTVLRPKHGIYLHLKKL 504
>CP44_RABIT (P10611) Cytochrome P450 4A4 precursor (EC 1.14.14.1)
(CYPIVA4) (Prostaglandin omega-hydroxylase) (P450-P-2)
Length = 510
Score = 154 bits (388), Expect = 5e-37
Identities = 114/437 (26%), Positives = 206/437 (47%), Gaps = 34/437 (7%)
Query: 14 YWL-GTEPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDR--DPMFGSGLVMVEGNDWVR 70
+WL G + L + + ++LK V+ R P RN + P G GL++++G W +
Sbjct: 88 WWLSGNKARLLVYDPDYLK-----VILGR-SDPKAPRNYKLMTPWIGYGLLLLDGQTWFQ 141
Query: 71 HRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIAKT 130
HR ++ PAF+ LK +M++S M+DRW I+ + +++ + + + + I K
Sbjct: 142 HRRMLTPAFHYDILKPYVGLMVDSVQIMLDRWEQLIS-QDSSLEIFQHVSLMTLDTIMKC 200
Query: 131 SFGAE-----DENAKEVFDKLRALQMTLFNTNR---------YVGVPFGKYFNVKKNLEA 176
+F + D N+ + L +F R Y P G+ F+ L
Sbjct: 201 AFSYQGSVQLDRNSHSYIQAINDLNNLVFYRARNVFHQSDFLYRLSPEGRLFHRACQLAH 260
Query: 177 KKLGKEIDKLLLSIV-EARKNSPKQNSQKDLLGLLLKENNEDGKLGKTLTSREVVDECKT 235
+ + I + + E ++ + D L +LL E+G +L+ +++ E T
Sbjct: 261 EHTDRVIQQRKAQLQQEGELEKVRRKRRLDFLDVLLFAKMENGS---SLSDQDLRAEVDT 317
Query: 236 FFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNN-ELDITMLSGLKKMKCVMN 294
F F GH+TTA ++W LATH + Q++ REEI+ ++G+ + L + +
Sbjct: 318 FMFEGHDTTASGVSWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDQMPYTTMCIK 377
Query: 295 EVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPERF 353
E LRLYPP P+V RQ + + D ++P G +++ + +H++P++W + F P RF
Sbjct: 378 EALRLYPPVPSVTRQLSKPVTFPDGRSLPKGVILFLSIYGLHYNPKVW-QNPEVFDPFRF 436
Query: 354 MDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSYQHSPAIM 413
D H +LPF G R C+G+ E K+ + + L F P+ P
Sbjct: 437 APD---SAYHSHAFLPFSGGARNCIGKQFAMRELKVAVALTLVRFELLPDPTRIPIPIAR 493
Query: 414 LSLRPAHGLPLIVQPLN 430
+ L+ +G+ L ++ L+
Sbjct: 494 VVLKSKNGIHLRLRKLH 510
>YS24_CAEEL (Q09653) Putative cytochrome P450 CYP13A10 (EC 1.14.-.-)
Length = 534
Score = 153 bits (387), Expect = 7e-37
Identities = 120/444 (27%), Positives = 205/444 (46%), Gaps = 53/444 (11%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWG-KPSVFRNDRDPMFGSGLVMVEGND 67
G ++ Y GT L +++ + ++++ E +G K + + D + + L +G
Sbjct: 65 GPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDNFYGRKLNPIQGDPEKDERTNLFSAQGFR 124
Query: 68 WVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEII 127
W R R I +P F+ +L+ + + +S +++ Q + G +IDM + + I
Sbjct: 125 WKRLRAISSPTFSNNSLRKINVTVEDSAMELLRHIEEQTSEGQ-QIDMLQFYQEFTMDTI 183
Query: 128 AKTSFGAEDENAKEVFDKLRALQMTLFNTNR----YVGVPFG------KYFNVKKNLEAK 177
+ + G D + + L +F NR +G F ++F +K L
Sbjct: 184 GRIAMGQTDSQMFK--NPLLKFVRAIFGDNRKHIPLIGGVFPTLAQVFRFFMLKFPLLGA 241
Query: 178 KLGKEIDKLLLSIVEAR--------KNSPKQNSQKDLLGLLLKENNED--------GKLG 221
++K +++ V+ R KN + +D + L L+ +D G
Sbjct: 242 ANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFS 301
Query: 222 KT----------------------LTSREVVDECKTFFFGGHETTALAITWTLLLLATHE 259
KT LT++E+V +C F G +TTAL++++T LLATH
Sbjct: 302 KTSSYVSFRRKIIPEFKKLQGNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHP 361
Query: 260 DWQNQLREEIKEVVGNNELDITMLSGLKKMKCVMNEVLRLYPPAPNVQ-RQAREDIQVDD 318
+ Q +L+EEI+ + LS LK M C++ E LRLYP R+ ++ +
Sbjct: 362 EVQKKLQEEIERECIEPSISFDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGN 421
Query: 319 VTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCV 378
V V GT + +D ++H D ++WGDD EFKPER++D K GY+ FG G R CV
Sbjct: 422 VEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQKGGYISFGLGPRQCV 481
Query: 379 GRNLTFMEYKIVLTILLSNFTFKV 402
G L +ME K++L +L +TF+V
Sbjct: 482 GMRLAYMEEKMLLAHILRKYTFEV 505
>CPF8_HUMAN (P98187) Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)
Length = 520
Score = 153 bits (387), Expect = 7e-37
Identities = 114/439 (25%), Positives = 202/439 (45%), Gaps = 28/439 (6%)
Query: 12 FIYWLGT-EPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDWVR 70
F+ WLG P + + + + ++ + A K VF P G GL++ G+ W
Sbjct: 88 FVRWLGPITPIINLCHPDIVRSVINTSDAIT-DKDIVFYKTLKPWLGDGLLLSVGDKWRH 146
Query: 71 HRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIAKT 130
HR ++ PAF+ LK + +S N M +W G+ +D+ + I + + + K
Sbjct: 147 HRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKC 206
Query: 131 SFGAEDENAKEVFDKLRALQ----MTLFNTNRYVGVPFGKYFNVKKNLEAKKLGKEIDKL 186
F + ++ + + A+ + + N++ YF + + +
Sbjct: 207 IFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDF 266
Query: 187 LLSIVEARKNSPKQNSQKDLLGLLLKENNED---------GKLGKTLTSREVVDECKTFF 237
++++ R+ + D L K D K GK L+ ++ E TF
Sbjct: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326
Query: 238 FGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGN---NELDITMLSGLKKMKCVMN 294
FGGH+TTA ++W L LA H ++Q + R+E++E++ + E++ L+ L + +
Sbjct: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386
Query: 295 EVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKPERF 353
E LRL+PP P R +D+ + D +P G I++ A+HH+P +W D + P RF
Sbjct: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRF 445
Query: 354 MDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSY---QHSP 410
D N + M ++PF G R C+G+ E K+VL + L F++ P + + +P
Sbjct: 446 -DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTL--LRFRILPDHREPRRTP 502
Query: 411 AIMLSLRPAHGLPLIVQPL 429
I+ LR GL L V+PL
Sbjct: 503 EIV--LRAEDGLWLRVEPL 519
>CP43_RAT (P20817) Cytochrome P450 4A3 precursor (EC 1.14.15.3)
(CYPIVA3) (Lauric acid omega-hydroxylase) (P450-LA-omega
3)
Length = 507
Score = 153 bits (387), Expect = 7e-37
Identities = 105/393 (26%), Positives = 179/393 (44%), Gaps = 25/393 (6%)
Query: 54 PMFGSGLVMVEGNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEI 113
P G GL+++ G W +HR ++ PAF+ LK +M +S N M+D+W +++ +H +
Sbjct: 122 PWIGYGLLLLNGKKWFQHRRMLTPAFHYGILKPYVKIMADSVNIMLDKW-EKLDDQDHPL 180
Query: 114 DMEKEIITIAGEIIAKTSFGAE-----DENAKEVFDKLRALQMTLFNTNRYVGVPFGKYF 168
++ + + + + K +F + D N++ + L F R +
Sbjct: 181 EIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIY 240
Query: 169 NVKKNLEAKKLGKEIDKLLLSIVEARKNSPKQNSQK----------DLLGLLLKENNEDG 218
N+ + + +I V + + QN ++ D L +LL EDG
Sbjct: 241 NMSSDGRLSRRACQIAHEHTDGVIKMRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDG 300
Query: 219 KLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGN-NE 277
K +L+ ++ E TF F GH+TTA I+W LATH + Q + REE++ ++G+
Sbjct: 301 K---SLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTS 357
Query: 278 LDITMLSGLKKMKCVMNEVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHH 336
+ L + + E LRLYPP P+V R+ + D ++P G I + +HH
Sbjct: 358 VTWDHLDQIPYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHH 417
Query: 337 DPELWGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLS 396
+P W + F P RF D +H YLPF G R C+G+ E K+ + + L
Sbjct: 418 NPSYW-PNPKVFDPSRFSPD---SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLL 473
Query: 397 NFTFKVSPSYQHSPAIMLSLRPAHGLPLIVQPL 429
F P+ P L L+ +G+ L ++ L
Sbjct: 474 RFELLPDPTRIPVPMARLVLKSKNGIHLRLKKL 506
>CPF2_HUMAN (P78329) Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2)
(Leukotriene-B(4) omega-hydroxylase) (Leukotriene-B(4)
20-monooxygenase) (Cytochrome P450-LTB-omega)
Length = 520
Score = 152 bits (384), Expect = 2e-36
Identities = 122/443 (27%), Positives = 206/443 (45%), Gaps = 34/443 (7%)
Query: 12 FIYWLGT-EPFLYIANAEFLKKMSTEVMAKRWGKPSVFRNDRDPMFGSGLVMVEGNDWVR 70
F W+G P L + + + ++ + A K F + +P G GL++ G+ W R
Sbjct: 88 FKVWMGPISPLLSLCHPDIIRSV-INASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSR 146
Query: 71 HRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGEIIAKT 130
HR ++ PAF+ LK + ES N M +W + G+ +DM + I + + + K
Sbjct: 147 HRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKC 206
Query: 131 SFGAEDENAKEVFDKLRA-LQMTLFNTNRY----VGVPFGKYFNVKKNLEAKKLGKEIDK 185
F + ++ + + A L+++ + R+ + + F Y + D
Sbjct: 207 VFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDF 266
Query: 186 LLLSIVEARKNSPKQ-----------NSQKDLLGLLLKENNEDGKLGKTLTSREVVDECK 234
I E R+ P Q + D + +LL +EDGK L+ ++ E
Sbjct: 267 TDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGK---KLSDEDIRAEAD 323
Query: 235 TFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGN---NELDITMLSGLKKMKC 291
TF F GH+TTA ++W L LA H ++Q + R+E++E++ + E++ L+ L +
Sbjct: 324 TFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTM 383
Query: 292 VMNEVLRLYPPAPNVQRQAREDIQV-DDVTVPNGTNMWIDVVAMHHDPELWGDDVNEFKP 350
M E LRL+PP P + R +DI + D +P G I V HH+P +W D + P
Sbjct: 384 CMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYDP 442
Query: 351 ERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTFKVSPSY---Q 407
RF D N + + ++PF G R C+G+ E K+VL + L F+V P + +
Sbjct: 443 FRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL--LRFRVLPDHTEPR 499
Query: 408 HSPAIMLSLRPAHGLPLIVQPLN 430
P ++ LR GL L V+PL+
Sbjct: 500 RKPELV--LRAEGGLWLRVEPLS 520
>YRV3_CAEEL (Q27515) Putative cytochrome P450 CYP13A6 (EC 1.14.-.-)
Length = 518
Score = 150 bits (380), Expect = 5e-36
Identities = 117/437 (26%), Positives = 209/437 (47%), Gaps = 44/437 (10%)
Query: 9 GKVFIYWLGTEPFLYIANAEFLKKMSTEVMAKRWGK---PSVFRNDRDPMFGSGLVMVEG 65
G V+ + G + + I+ E + ++ + +G+ P + ++D + +G
Sbjct: 63 GPVYGFTEGPQQTMIISEPEMVNEIFKKQFDNFYGRKLRPIIGDPEKDKRVN--IFSTQG 120
Query: 66 NDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDMEKEIITIAGE 125
W R R + +P+F+ +L+ + + + E +++ ++ N +IDM
Sbjct: 121 KRWKRLRTLSSPSFSNNSLRKVRNSVQECGTEILWNIEQKVR-KNEDIDMLIVYQEYTLG 179
Query: 126 IIAKTSFGAEDEN--AKEVFDKLRALQMTLFNTNRYVGV--PF-GKYFNVKKNLEAKKL- 179
+I++ + G + N + K++A+ ++ G+ P G + + K L A +
Sbjct: 180 VISRIALGQSESNMFKNPLLPKVQAIFNGSWHVFLITGIFPPLAGVFRKMSKMLPASFIP 239
Query: 180 GKEIDKLLLSIVEARKNSPKQNSQK--------DLLGLLLK-----------ENNED--- 217
+I L+ V+AR + ++ K D + L L E NED
Sbjct: 240 AFKIFDLIEVAVQARIDQRAKDEIKGVEPGEPQDFIDLFLDARVPDVKILSGEANEDFAK 299
Query: 218 ---GKLGKTLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVG 274
K+ K LT E++ +C F G +TTAL++++ LLATH + Q +L+EE+
Sbjct: 300 SSVVKINKELTFDEIIAQCFVFLAAGFDTTALSLSYATYLLATHPEIQTKLQEEVDRECP 359
Query: 275 NNELDITMLSGLKKMKCVMNEVLRLYPPAPNVQ-RQAREDIQVDDVTVPNGTNMWIDVVA 333
+ E+ LS LK ++CVM E LRLYP R+ + ++ V G N+ +D
Sbjct: 360 DPEIFFDHLSKLKYLECVMKETLRLYPLGTTANTRKCMRETTINGVNFDEGMNIQVDTWT 419
Query: 334 MHHDPELWGDDVNEFKPERFMDDVNGGC---KHKMGYLPFGFGGRMCVGRNLTFMEYKIV 390
+HH+P +WG+DV +FKPER+ NG C +H Y+PFG G R C+G L ME KI+
Sbjct: 420 LHHNPRIWGEDVEDFKPERW---ENGACEHLEHNGSYIPFGSGPRQCIGMRLAQMEQKIL 476
Query: 391 LTILLSNFTFKVSPSYQ 407
L +L ++F+ + + Q
Sbjct: 477 LAQILKEYSFRTTKNTQ 493
>CP4B_RAT (P15129) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1)
(P450-isozyme 5)
Length = 511
Score = 150 bits (380), Expect = 5e-36
Identities = 108/389 (27%), Positives = 184/389 (46%), Gaps = 22/389 (5%)
Query: 57 GSGLVMVEGNDWVRHRHIVAPAFNPLNLKVMASMMIESTNQMIDRWTSQINFGNHEIDME 116
G GL++++G W +HR ++ P F+ LK ++ EST M+D+W + + N D+
Sbjct: 123 GKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKAS-ENKSFDIF 181
Query: 117 KEIITIAGEIIAKTSFGAEDENA--KEVFDKLRALQMTLFNTNRYVGVPFGKYF------ 168
++ +A + + K +FG D ++ L +TL R + F
Sbjct: 182 CDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTP 241
Query: 169 NVKKNLEAKKLGK----EIDKLLLSIVEARKNSPK--QNSQKDLLGLLLKENNEDGKLGK 222
+ ++ L A K+ E+ + + ++ K K Q D L +LL +E G
Sbjct: 242 HGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGI--- 298
Query: 223 TLTSREVVDECKTFFFGGHETTALAITWTLLLLATHEDWQNQLREEIKEVVGNNE-LDIT 281
L+ E+ E TF F GH+TT I+W L +A + + Q REE++ ++G+ +
Sbjct: 299 KLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDSFQWD 358
Query: 282 MLSGLKKMKCVMNEVLRLYPPAPNVQRQAREDIQ-VDDVTVPNGTNMWIDVVAMHHDPEL 340
L+ + + M E RLYPP P V RQ + + VD ++P G+ + + + A+H + +
Sbjct: 359 DLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTV 418
Query: 341 WGDDVNEFKPERFMDDVNGGCKHKMGYLPFGFGGRMCVGRNLTFMEYKIVLTILLSNFTF 400
W D F P RF + N +H ++PF G R C+G+ E K+V + L F F
Sbjct: 419 WPDP-EVFDPLRFSPE-NAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF 476
Query: 401 KVSPSYQHSPAIMLSLRPAHGLPLIVQPL 429
+ PS L LR +G+ L ++PL
Sbjct: 477 SLDPSKMPIKVPQLILRSKNGIHLYLKPL 505
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,581,137
Number of Sequences: 164201
Number of extensions: 2299363
Number of successful extensions: 7653
Number of sequences better than 10.0: 724
Number of HSP's better than 10.0 without gapping: 587
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 5502
Number of HSP's gapped (non-prelim): 813
length of query: 430
length of database: 59,974,054
effective HSP length: 113
effective length of query: 317
effective length of database: 41,419,341
effective search space: 13129931097
effective search space used: 13129931097
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Medicago: description of AC131240.9