BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC127429.13 - phase: 0 /pseudo
(1603 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
HELS_METMA (Q8PZR7) Putative ski2-type helicase (EC 3.6.1.-) 180 3e-44
HELS_THEAC (Q9HJX7) Putative ski2-type helicase (EC 3.6.1.-) 173 4e-42
HELS_METAC (Q8TL39) Putative ski2-type helicase (EC 3.6.1.-) 172 9e-42
HELS_AERPE (Q9YFQ8) Putative ski2-type helicase (EC 3.6.1.-) 169 6e-41
HELS_THEVO (Q97AI2) Putative ski2-type helicase (EC 3.6.1.-) 168 1e-40
HELS_PYRHO (O59025) Putative ski2-type helicase (EC 3.6.1.-) 164 2e-39
HELS_HALN1 (Q9HMV6) Putative ski2-type helicase (EC 3.6.1.-) 161 2e-38
HELS_PYRAB (Q9V0A9) Putative ski2-type helicase (EC 3.6.1.-) 141 2e-32
HELS_SULTO (Q974S1) Putative ski2-type helicase (EC 3.6.1.-) 140 4e-32
HELS_SULSO (Q97VY9) Putative ski2-type helicase (EC 3.6.1.-) 135 1e-30
HELS_METTH (O26901) Putative ski2-type helicase (EC 3.6.1.-) 130 2e-29
HELS_PYRFU (O73946) Putative ski2-type helicase (EC 3.6.1.-) 125 1e-27
BRR2_YEAST (P32639) Pre-mRNA splicing helicase BRR2 (EC 3.6.1.-)... 121 2e-26
U520_HUMAN (O75643) U5 small nuclear ribonucleoprotein 200 kDa h... 117 3e-25
K052_HUMAN (P42285) Protein KIAA0052 (Fragment) 115 7e-25
U520_DROME (Q9VUV9) Putative U5 small nuclear ribonucleoprotein ... 114 2e-24
U520_CAEEL (Q9U2G0) Putative U5 small nuclear ribonucleoprotein ... 112 8e-24
HEL1_HUMAN (Q8N3C0) Activating signal cointegrator 1 complex sub... 111 2e-23
HFM1_YEAST (P51979) ATP-dependent DNA helicase MER3 (EC 3.6.1.-)... 107 3e-22
YG5O_YEAST (P53327) Probable helicase YGR271W (EC 3.6.1.-) 106 6e-22
>HELS_METMA (Q8PZR7) Putative ski2-type helicase (EC 3.6.1.-)
Length = 730
Score = 180 bits (456), Expect = 3e-44
Identities = 188/689 (27%), Positives = 298/689 (42%), Gaps = 96/689 (13%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGN-----QGGGSLPKDTSVAVCTIEKA 56
A+ ++P ++ +EK ++ LG V G+ +G G + V T EK
Sbjct: 70 ALYIVPLRALASEKFRRFQEF-SVLGMRVGISTGDYDRRDEGLGI----NDIIVATSEKT 124
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+SL+ E + E+ ++V DE+H++ P RG LE+ L+KLR
Sbjct: 125 DSLLRN--ETAWMQEISVVVADEVHLIDSPDRGPTLEITLSKLR---------------- 166
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKS 176
+ +P+ Q++ +SAT+ N +A WL A L +E+RP L E + Y K
Sbjct: 167 -----RMNPS--CQVLALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKD 219
Query: 177 MELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFT 236
E +G D V L + ++EG L+F SSRK C A+ +K
Sbjct: 220 KE--------KPVGQPTKDEAVNLVLDTIKEGGQCLVFESSRKNCMGFAKKAVSAVKKTL 271
Query: 237 VDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRK 296
NE+ A I I + + VL +G AFHHAGLT RE+VE +R+
Sbjct: 272 S--NEDRETLAGIADEI--IENSETDVSSVLATCVRSGTAFHHAGLTTPLRELVENGFRE 327
Query: 297 GLLRVLTATSTLAAGVNLPARRVIFRQPR-----IGCDFIDGTRYMQMAGRAGRTGIDTK 351
G ++++++T TLAAG+NLPARRVI R R G I Y QMAGRAGR +D
Sbjct: 328 GRIKIISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPY 387
Query: 352 GESVLICKPQE--LKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQTANDIHR 409
GE+VL+ K E + + + S L + N + IL ++ G +T ++
Sbjct: 388 GEAVLLAKSYEEFVFLFEKYIEAGAEDIWSKLGTE-NALRTHILSTISNGFARTREEL-M 445
Query: 410 KFLEWNEDTKLYSTTPLGRASFGSSLCPEESLIVLADLSRAREGFVLASDLHLVYLVTPI 469
FLE YS +FG S +E L L REG + LV V
Sbjct: 446 DFLEATFFAFQYS-------NFGLSAVVDECLDFL-----RREGMLEKDPDALVSTVFGK 493
Query: 470 NVDVEPDWESYYERFVKLSPLDQSVGNRVGVTEPFLMRMAHGVPMGSNKSRWSNNKRQNQ 529
V Y + + + + + +TE L+ + P R + Q+
Sbjct: 494 LV------SRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTP----DMRLMYMRSQDY 543
Query: 530 HGMSSGIVNSDDQTLRVCKRFYVA------------LILSLLVQETPVGEVCEAFKVARG 577
++ ++ + +V F +A L+L + E P E+C F + G
Sbjct: 544 QEVNDYVMAHAGEFSKVPNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGIGEG 603
Query: 578 MVQGLQENAGRFASMVAVFCERLGWHDFEGL--VAKFQNRVSFGVRAEVVELTTIPYVKG 635
+ + A ++ V + G D +G ++ + R+ +G E+++L I V
Sbjct: 604 DIHATADIA---EWIMHVTAQLAGLLDLKGAKEASELEKRIRYGAAPELMDLLDIRSVGR 660
Query: 636 SRARALYKAGLRTPLAIAEASIPELVKAL 664
RAR LY+AG ++ +A AS PE + L
Sbjct: 661 VRARKLYEAGFKSTAELAAAS-PEHIAVL 688
>HELS_THEAC (Q9HJX7) Putative ski2-type helicase (EC 3.6.1.-)
Length = 674
Score = 173 bits (438), Expect = 4e-42
Identities = 180/671 (26%), Positives = 300/671 (43%), Gaps = 94/671 (14%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGG-SLPKDTSVAVCTIEKANSLI 60
+I ++P S+ EK L +L + LG V+ G+ K + T EKA+SL+
Sbjct: 68 SIYIVPLRSLAMEKFSELSRLRD-LGLKVKMSIGDYDDSPDFIKRYDAVILTSEKADSLL 126
Query: 61 NRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSS 120
+ + L+++G++V+DE+H +GD RG LE + + RY +
Sbjct: 127 HH--DPYILNDVGLLVLDEIHTIGDESRGPTLETVASIARYVNPD--------------- 169
Query: 121 DKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKSMELS 180
++I+ +SAT+ N +A WL A+L +++FRPVPL+ I +Y + L
Sbjct: 170 --------VRILALSATVSNAMELASWLDASLIKSDFRPVPLKTGI-----LYRDQLYLD 216
Query: 181 RTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFTVDIN 240
G + ++ E V++ VL+F SSRK E TAR +A+ S
Sbjct: 217 GKRRSGVSIN--------QIIRETVEDNGQVLMFVSSRKKAEDTARDLAQIFGS------ 262
Query: 241 ENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRKGLLR 300
+ N + + + + D +L E P GVAFHHAGL+ ++R +E +R ++
Sbjct: 263 DANIKISSDETNV---------YDDMLNEILPRGVAFHHAGLSNDQRAFIEREFRARRIK 313
Query: 301 VLTATSTLAAGVNLPARRVIFRQ-PRIGCD---FIDGTRYMQMAGRAGRTGIDTKGESVL 356
V+ AT TLAAGVNLPAR VI R R G D ++ QM GRAGR G D G ++
Sbjct: 314 VIVATPTLAAGVNLPARLVIVRDITRWGSDGISYLTNMEIKQMIGRAGRPGYDQYGIGLI 373
Query: 357 ICKPQ-ELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQTANDIHRKFLEWN 415
Q + L+ P+ S L + + L ++ G+ ++ +DI
Sbjct: 374 YVSSQSSYEAAKDYLSTDPEPVVSYLGNEAK-VRFNTLAAISMGLARSPSDI-------- 424
Query: 416 EDTKLYSTTPLGRASFGSSLCPEESLIVLADLSRAREGFVLAS-DLHLVYLVTPINVDVE 474
K Y TT L + G L E+ L L + GF+ S DL L + D+
Sbjct: 425 --MKFYETT-LFFSQNGKDLLEEKISASLKFLE--KNGFIKQSPDLRTTQL-GKVTSDLY 478
Query: 475 PDWESYYERFVKLSPLDQSVGNRVGVTEPFLMRMAHGVPMGSNKSRWSNNKRQNQHGMSS 534
D ES R V V + + + + + + + K +S + + G+
Sbjct: 479 IDPESAL-RLVDFFDGPADVDHAI-----YYISLCREIVPFNIKDDYSAMEFLDDIGLID 532
Query: 535 GIVNSDDQTLRVCKRFYVALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRFASMVA 594
G +++ A++L + E + + + +A G +Q A + +A
Sbjct: 533 GDIDAAK----------TAIVLRDWISEASYKYLYDKYGIAPGDMQARISMADWLSYSLA 582
Query: 595 VFCERLGWHDFEGLVAKFQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAE 654
+ + ++ R+ G+R ++++L IP V RAR LY AGLR+ +A
Sbjct: 583 KL-SSIYKPEVRRMLEILNLRIKEGIREDILQLVLIPGVGRVRARRLYDAGLRSIEDVAS 641
Query: 655 ASIPELVKALF 665
AS P+ +KA++
Sbjct: 642 AS-PDRIKAIY 651
>HELS_METAC (Q8TL39) Putative ski2-type helicase (EC 3.6.1.-)
Length = 730
Score = 172 bits (435), Expect = 9e-42
Identities = 187/689 (27%), Positives = 296/689 (42%), Gaps = 96/689 (13%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGN-----QGGGSLPKDTSVAVCTIEKA 56
A+ ++P ++ +EK + E LG V G+ +G G + V T EK
Sbjct: 70 ALYIVPLRALASEKFRRFQDFSE-LGIRVGISTGDYDRRDEGLGI----NDIIVATSEKT 124
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+SL+ E + E+ ++V+DE+H++ RG LE+ L KLR
Sbjct: 125 DSLLRN--ETAWMQEISVVVVDEVHLIDSADRGPTLEVTLAKLR---------------- 166
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKS 176
K +P QI+ +SAT+ N +A WL A L +E+RP L E + + + K
Sbjct: 167 -----KMNPF--CQILALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFFDGTFFCKD 219
Query: 177 MELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFT 236
E P D + L + ++EG L+F SSRK C A+ +K T
Sbjct: 220 KEKLIEQPT--------KDEAINLVLDTLREGGQCLVFESSRKNCMGFAKKATSAVKK-T 270
Query: 237 VDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRK 296
+ + + A I I L VL AG AFHHAGLT RE+VET +R+
Sbjct: 271 LSAEDKE-KLAGIADEI--LENSETDTASVLASCVRAGTAFHHAGLTSPLRELVETGFRE 327
Query: 297 GLLRVLTATSTLAAGVNLPARRVIFRQPR-----IGCDFIDGTRYMQMAGRAGRTGIDTK 351
G ++++++T TLAAG+NLPARRVI R R G I Y QMAGRAGR +D
Sbjct: 328 GYVKLISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPY 387
Query: 352 GESVLICKPQE--LKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQTANDIHR 409
GE+VL+ K E L + + S L + N + +L ++ G +T ++
Sbjct: 388 GEAVLLAKSYEELLFLFEKYIEAGAEDIWSKLGTE-NALRTHVLSTISNGFARTKEEL-M 445
Query: 410 KFLEWNEDTKLYSTTPLGRASFGSSLCPEESLIVLADLSRAREGFVLASDLHLVYLVTPI 469
FLE YS +FG S+ +E L L + LV+ +
Sbjct: 446 DFLEATFFAYQYS-------NFGLSVVVDECLNFLRQEGMLEQDSDALISTMFGKLVSRL 498
Query: 470 NVDVEPDWESYYERFVKLSPLDQSVGNRVGVTEPFLMRMAHGVPMGSNKSRWSNNKRQNQ 529
+D + + + + + +TE L+ + P R + Q+
Sbjct: 499 YIDP-----------LSAALIAKGLREAGTLTELTLLHLVCSTP----DMRLMYMRSQDY 543
Query: 530 HGMSSGIVNSDDQTLRVCKRFYV------------ALILSLLVQETPVGEVCEAFKVARG 577
++ ++ ++ +V F + +L+L + E P E+C F G
Sbjct: 544 QDINDFVMAHAEEFSKVPSPFNIVEYEWFLSEVKTSLLLMDWIHEKPENEICLKFGTGEG 603
Query: 578 MVQGLQENAGRFASMVAVFCERLGWHDFEGL--VAKFQNRVSFGVRAEVVELTTIPYVKG 635
+ + A + VA RL D +G A+ + R+ +G E+++L I +
Sbjct: 604 DIHTTADIA-EWIMHVATQLARL--LDLKGAKEAAELEKRIHYGAGPELMDLLDIRGIGR 660
Query: 636 SRARALYKAGLRTPLAIAEASIPELVKAL 664
RAR LY AG ++ +A A+ PE V AL
Sbjct: 661 VRARKLYGAGFKSTADLAGAT-PEKVAAL 688
>HELS_AERPE (Q9YFQ8) Putative ski2-type helicase (EC 3.6.1.-)
Length = 702
Score = 169 bits (428), Expect = 6e-41
Identities = 125/410 (30%), Positives = 206/410 (49%), Gaps = 63/410 (15%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKDTSVAVCTIEKANSLIN 61
A ++P S+ EK +L +G ++ G+ G P + V + T EK +SL+
Sbjct: 42 AFYLVPLKSVAYEKYTSFS-ILSRMGLKLKISVGDFREG--PPEAPVVIATYEKFDSLLR 98
Query: 62 RLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSSD 121
+ + ++++DE+H V DPKRG +LE +++++ +AGE
Sbjct: 99 --VSPSLARNVSVLIVDEIHSVSDPKRGPILESIVSRMLASAGEA--------------- 141
Query: 122 KNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKSMELSR 181
Q+VG+SAT+PN +A+W+ + ++ +RPVPL EY+ +Y+ + L R
Sbjct: 142 --------QLVGLSATVPNAGEIAEWIGGKIVESSWRPVPLREYVFKEYKLYSPTGGL-R 192
Query: 182 TIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFTVDINE 241
+P+ L + ++L E +++G L+F SR+ + A+ AK L + E
Sbjct: 193 EVPRVYGL------YDLDLAAEAIEDGGQALVFTYSRRRAVTLAKRAAKRLGR-RLSSRE 245
Query: 242 NNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRKGLLRV 301
A+ + A + P + L AG+A+HHAGL R+ VE +R G ++V
Sbjct: 246 ARVYSAEASRAEGA----PRSVAEELASLIAAGIAYHHAGLPPSLRKTVEEAFRAGAVKV 301
Query: 302 LTATSTLAAGVNLPARRVI----------FRQPRIGCDFIDGTRYMQMAGRAGRTGIDTK 351
+ +T TLAAGVNLPARRV+ FR+P I Y QMAGRAGR G+D
Sbjct: 302 VYSTPTLAAGVNLPARRVVIDSYYRYEAGFREP------IRVAEYKQMAGRAGRPGLDEF 355
Query: 352 GESVLIC----KPQELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVA 397
GE++++ +P++L + G + + S L+ L G+ H IL +VA
Sbjct: 356 GEAIIVAERLDRPEDL--ISGYIRAPPERVESRLA-GLRGLRHFILGIVA 402
Score = 39.7 bits (91), Expect = 0.067
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 1/111 (0%)
Query: 553 ALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRFASMVAVFCERLGWHD-FEGLVAK 611
A++L L + E + + V G + + A AS ++ LG + +++
Sbjct: 541 AVVLKLWIDEASEDTIYGEWGVHTGDLLNMVSTAEWIASGLSRIAPYLGLNSKVSHILSV 600
Query: 612 FQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAEASIPELVK 662
R+ GV+ E+++L IP V RAR L++AG R+ +A A +L++
Sbjct: 601 IARRIKHGVKPELLQLVEIPGVGRVRARILFEAGYRSIEDLATARAEDLMR 651
>HELS_THEVO (Q97AI2) Putative ski2-type helicase (EC 3.6.1.-)
Length = 674
Score = 168 bits (425), Expect = 1e-40
Identities = 124/360 (34%), Positives = 176/360 (48%), Gaps = 59/360 (16%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGG-SLPKDTSVAVCTIEKANSLI 60
+I ++P S+ EK E L +L E LG V+ GN K V + T EKA+SL+
Sbjct: 68 SIYIVPLRSLAMEKYEELSRLRE-LGMRVKLSIGNYDDTPDFIKRYDVVILTSEKADSLM 126
Query: 61 NRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSS 120
+ + + E+G++VIDE+HM+GD RG LE ++T RY E
Sbjct: 127 HH--DPYMMEEVGLMVIDEIHMIGDEYRGPTLETVITTARYVNPE--------------- 169
Query: 121 DKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKSMELS 180
+I+ +SAT+ N + +A+WL A+L ++ FRPVPL KVG +Y + L
Sbjct: 170 --------TRIIALSATVSNASEIAEWLNASLIKSSFRPVPL----KVG-ILYRNRLFLD 216
Query: 181 RTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFTVDIN 240
D+ L E V +G VLIF SSRK E A+++++ IN
Sbjct: 217 GDARSDVDIN--------LLVKETVDDGGQVLIFVSSRKRAEDMAKNLSQLFDP----IN 264
Query: 241 ENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRKGLLR 300
+ D D +L E P GV+FHHAGL+ E+R +E +R L+
Sbjct: 265 DLKVSSEDANV-----------YDDLLNEMLPHGVSFHHAGLSNEQRSFIEKAFRHRKLK 313
Query: 301 VLTATSTLAAGVNLPARRVIF----RQPRIGCDFIDGTRYMQMAGRAGRTGIDTKGESVL 356
V+ AT TLAAGVNLPAR VI R +G ++ QM GRAGR G D G ++
Sbjct: 314 VIVATPTLAAGVNLPARLVIVKDVTRYGDLGITYLSNMEVKQMIGRAGRPGYDQYGIGII 373
Score = 38.9 bits (89), Expect = 0.11
Identities = 31/113 (27%), Positives = 52/113 (45%), Gaps = 2/113 (1%)
Query: 553 ALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRFASMVAVFCERLGWHDFEGLVAKF 612
AL+L + E + E + VA G +Q NA + +A + + +
Sbjct: 541 ALVLREWISEASTRRIFEMYGVAPGDLQARVNNADWISYSLAHLAS-IFKPERRRKLEIL 599
Query: 613 QNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAEASIPELVKALF 665
R+ G+R E+++L IP + RAR LY+AG+ +A S P +K L+
Sbjct: 600 NMRIKEGIREELMDLVLIPAIGRVRARRLYEAGIHNVQELA-FSDPSRIKMLY 651
>HELS_PYRHO (O59025) Putative ski2-type helicase (EC 3.6.1.-)
Length = 715
Score = 164 bits (414), Expect = 2e-39
Identities = 167/674 (24%), Positives = 289/674 (42%), Gaps = 79/674 (11%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKDT-----SVAVCTIEKA 56
A+ ++P ++ EK + K E LG V G+ KD + + T EK
Sbjct: 71 AVYLVPLKALAEEKFKEF-KDWEELGLKVAMATGDYDS----KDEWLGGYDIIIATAEKF 125
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+SL+ + + ++V+DE+H++G RG LE ++T++ A
Sbjct: 126 DSLLRH--GSSWIRNVKVLVVDEIHLIGSRDRGATLEFIITQMLNRA------------- 170
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKS 176
QI+G+SAT+ N +A+WL A L ++++RPV L + ++ +
Sbjct: 171 -------------QIIGLSATIGNPEELAEWLNAKLIKSDWRPVKLRRGVFYQGFVFWED 217
Query: 177 MELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFT 236
+ + + EL + ++ + L+F + R+ E TA ++K +++F
Sbjct: 218 GKTEKF------------NSWEELVYDAIKRSKGSLVFVNMRRKAEKTALELSKKIRNFL 265
Query: 237 VDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRK 296
E ++ SL + P + L + GVAFHHAGL EER +VE ++K
Sbjct: 266 T-----KKELRELKELAESLEENPT--NEKLAKALQGGVAFHHAGLGREERVLVEENFKK 318
Query: 297 GLLRVLTATSTLAAGVNLPARRVI----FRQPRIGCDFIDGTRYMQMAGRAGRTGIDTKG 352
GL++V+ AT TL+AG+N PA RVI +R G + I QM GRAGR D G
Sbjct: 319 GLIKVVVATPTLSAGINTPAFRVIVRDTWRYSEFGMERIPILEIQQMMGRAGRPKYDEVG 378
Query: 353 ESVLICKPQELKKVMGLLNESCP-PLHSCLSED--LNGMTHAILEVVAGGIVQTANDIHR 409
E++++ +E VM + P L S LS + L G A++ + D
Sbjct: 379 EAIIVSTTEEPSTVMERYIKGKPEKLFSQLSNESILRGQILALIATFNFSSFREIYDFLE 438
Query: 410 KFLEWNEDTKLYSTTPLGRASFGSSLCPEESLIVLADLSRAREGFVLASDLHLVYLVTPI 469
+ + Y+ R L E I L D +A + + L++ + I
Sbjct: 439 RTFYAYQGKDPYTLEDRIRDIVYFLLENEFIEITLDDEIKALPLGIRTAKLYIDPMTAKI 498
Query: 470 NVDVEPDWESYYERFVKLSPLDQSVGNRVGVTEPFLMRMAHGVPMGSNKSRWSNNKRQNQ 529
D P ++ P + + + +T + +P G + ++ +
Sbjct: 499 FKDTLPK--------IEKDPNPLGILHVISLTPDLI-----PLPYGKKELPMLEDEYYSF 545
Query: 530 HGMSSGIVNSDDQTLRVCKRFYVALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRF 589
++ +D+ + + F AL+L+ + E P GE+ E F V G + + E A
Sbjct: 546 KDRLYFELDWEDER-KFLRAFKTALVLNAWINEVPEGEIVEKFNVEPGDIYRIVETAEWL 604
Query: 590 ASMVAVFCERLGW-HDFEGLVAKFQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRT 648
+ + L + D + + RV G+R E++ L +P + RARALY AG R
Sbjct: 605 VYSLKEIAKTLEYSQDVINYLETLRVRVKHGIREELIPLMELPMIGRKRARALYNAGFRD 664
Query: 649 PLAIAEASIPELVK 662
+I A EL++
Sbjct: 665 LESIKNARPAELLE 678
>HELS_HALN1 (Q9HMV6) Putative ski2-type helicase (EC 3.6.1.-)
Length = 783
Score = 161 bits (407), Expect = 2e-38
Identities = 126/417 (30%), Positives = 196/417 (46%), Gaps = 49/417 (11%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGN-QGGGSLPKDTSVAVCTIEKANSLI 60
A+ ++P ++ EKA+ E E G V GN + G+ D + V T EK +SL+
Sbjct: 80 ALYIVPLRALAGEKAQEFEAF-ERFGLSVGVSTGNYERDGARLADNDIVVATSEKVDSLV 138
Query: 61 NRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSS 120
G + ++ +V DE+H+V D RG LE+ L KLR +
Sbjct: 139 RN--GAGWIDDLSCVVADEVHLVDDDHRGPTLEVTLAKLRQQVAD--------------- 181
Query: 121 DKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSI-YNKSMEL 179
LQ+V +SAT+ N +A WL A L +++RP+ L + G S+ Y+ +
Sbjct: 182 --------LQVVALSATVGNAGELAAWLDAELVDSDWRPIELRTGVHYGQSLHYDDGTQA 233
Query: 180 SRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFTVDI 239
++ G+ D + + S L+F +SR+ E++AR +A +
Sbjct: 234 ELSVGSGSQTAAVVAD--------TLADDGSTLVFVNSRRNAEASARRLADVTGNALSSA 285
Query: 240 NENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRKGLL 299
ADI + I + + L + +G AFHHAGL E RE+VE +R L+
Sbjct: 286 ERER--LADIAAEIRGVSDTETSDE--LADAVASGAAFHHAGLAREHRELVEEAFRDRLV 341
Query: 300 RVLTATSTLAAGVNLPARRVIFRQ------PRIGCDFIDGTRYMQMAGRAGRTGIDTKGE 353
+ ++AT TLAAGVN PARRV+ R G +D QM GRAGR G+D GE
Sbjct: 342 KAVSATPTLAAGVNTPARRVVVRDWQRYDGTAGGMQPLDVLEVHQMFGRAGRPGLDPYGE 401
Query: 354 SVLICKP-QELKKVMGLLNESCP-PLHSCLSEDLNGMTHAILEVVAGGIVQTANDIH 408
+VL+ EL+++ + P P+ S L+ + TH +L +A G T + +H
Sbjct: 402 AVLLANSHDELEELFDRYVYADPEPVRSKLAAEPALRTH-VLAAIATGFTTTEDGLH 457
Score = 34.3 bits (77), Expect = 2.8
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 568 VCEAFKVARGMVQGLQENAGRFASMVAVFCERL-GWHDFE--GLVAKFQNRVSFGVRAEV 624
+ E + V G ++G E A + ERL G D E V + + RV +GVR E+
Sbjct: 637 IAERYDVGPGDIRGKVETAEWLLNAA----ERLAGELDVECGPAVREARKRVQYGVREEL 692
Query: 625 VELTTIPYVKGSRARALYKAGLRTPLAIAEASIPELVKALFESSSWGTEGSAQRSLQ 681
+ L + V RAR LY AG+ + A + K + + G +A+R L+
Sbjct: 693 LGLAGVRNVGRKRARRLYNAGVE-----SRADLRNADKGVVLGAVRGRAATAERILE 744
>HELS_PYRAB (Q9V0A9) Putative ski2-type helicase (EC 3.6.1.-)
Length = 715
Score = 141 bits (355), Expect = 2e-32
Identities = 109/370 (29%), Positives = 180/370 (48%), Gaps = 61/370 (16%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKDT-----SVAVCTIEKA 56
A+ ++P ++ EK K E LG V G+ KD + + T EK
Sbjct: 71 AVYIVPLKALAEEKFREF-KDWERLGLKVAMATGDYDS----KDEWLGKYDIIIATAEKF 125
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+SL+ + ++ ++VIDE+H++G RG LE ++T++ A
Sbjct: 126 DSLLRH--GSSWIRDVKMLVIDEIHLIGSRDRGATLEFIITQMLGRA------------- 170
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKS 176
QI+G+SAT+ N +A+WL A L ++++RPV L + + ++ +
Sbjct: 171 -------------QIIGLSATIGNPEELAEWLNAKLIRSDWRPVKLRKGVFYQGFVFWE- 216
Query: 177 MELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFT 236
D G + + EL + V++G+ L+F + R+ E TA +AK +K++
Sbjct: 217 -----------DGGSERYNSWEELVYDAVKKGKGALVFVNMRRKAEKTALELAKKVKNYL 265
Query: 237 VDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRK 296
+ E ++ SL + P + L + +GVAFHHAGL +ER +VE +RK
Sbjct: 266 -----DRKELRELRELAESLEENPT--NEKLAKALLSGVAFHHAGLGRDERVLVEDNFRK 318
Query: 297 GLLRVLTATSTLAAGVNLPARRVI----FRQPRIGCDFIDGTRYMQMAGRAGRTGIDTKG 352
GL++V+ AT TL+AG+N PA RVI +R G + I QM GRAGR D G
Sbjct: 319 GLIKVVVATPTLSAGINTPAFRVIIRDTWRYSEFGMERIPVLEVQQMMGRAGRPRYDEVG 378
Query: 353 ESVLICKPQE 362
E++++ +E
Sbjct: 379 EAIIVSTTEE 388
Score = 54.7 bits (130), Expect = 2e-06
Identities = 38/122 (31%), Positives = 58/122 (47%), Gaps = 13/122 (10%)
Query: 548 KRFYVALILSLLVQETPVGEVCEAFKVARGMVQGLQENA-------GRFASMVAVFCERL 600
+ F AL+L+ + E P GE+ E F V G + + E A G A ++ E +
Sbjct: 563 RAFKTALVLNAWINEVPEGEIVERFNVEPGDIYRIVETAEWLIYSLGEIAKVLEASQEVV 622
Query: 601 GWHDFEGLVAKFQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAEASIPEL 660
+ V + RV G+R E++ L +P V RARALY AG + +I A EL
Sbjct: 623 DY------VNTLRLRVKHGIREELIPLMELPMVGRKRARALYNAGFKDLESIRNAKPSEL 676
Query: 661 VK 662
++
Sbjct: 677 LR 678
>HELS_SULTO (Q974S1) Putative ski2-type helicase (EC 3.6.1.-)
Length = 704
Score = 140 bits (352), Expect = 4e-32
Identities = 113/382 (29%), Positives = 185/382 (47%), Gaps = 51/382 (13%)
Query: 48 VAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGI 107
+ V T EK +SL + L+E+ V+DE H + DP+RG +E + + A GI
Sbjct: 120 IIVTTYEKLDSLWRHKAKW--LNEVSYFVLDEFHYLNDPERGPTVESVAIR---AKKRGI 174
Query: 108 SKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIK 167
++G+SAT+ N +A+WL A L T +RPVPL+E I
Sbjct: 175 -----------------------VLGLSATISNGKEIANWLNAELVATNWRPVPLKEGI- 210
Query: 168 VGNSIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARH 227
IY + D ++ ++V +G VL+F SSRK E+TAR
Sbjct: 211 ----IYPEKKGFVVVYKDNTSRKVYGDDAIIAYTLDIVSKGGQVLVFRSSRKLAENTARK 266
Query: 228 VAKFLKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEER 287
+ +++ ++ + + +I I + + L GVA+HHAGL+ R
Sbjct: 267 IVQYMNFVKLE----DKKLLEIARKIKEVEDAGSNEKEDLYNLVLRGVAYHHAGLSKGLR 322
Query: 288 EIVETCYRKGLLRVLTATSTLAAGVNLPARRVI------FRQPRIG-CDFIDGTRYMQMA 340
+I+E+ +R +L+V+ AT TLAAGVNLPAR V+ + + +G D I Y QM+
Sbjct: 323 DIIESSFRDRILKVIVATPTLAAGVNLPARAVVIGDIYRYNRKVVGYMDLIPVMDYKQMS 382
Query: 341 GRAGRTGIDTKGESVLICK-PQELKKVM-GLLNESCPPLHSCLSEDLNGMTHAILEVVAG 398
GRAGR G D GE+V++ + +E +KV L P+ S L + + ++ ++A
Sbjct: 383 GRAGRPGFDENGEAVVVVRNKREAEKVYERYLMSDVEPIESKLGSE-SAFYSFLISIIAS 441
Query: 399 GIVQTANDIHRKFLEWNEDTKL 420
+T ++ +E+ ++T L
Sbjct: 442 EGEKTTEEL----MEYVKETLL 459
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Query: 604 DFEGLVAKFQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAEASIPELVKA 663
D + ++ + RV GV+ E++EL IP + RAR LY+ ++ P I PE VK
Sbjct: 628 DHKDILEELHARVKDGVKPELIELVKIPGIGRVRARLLYQHDIKKPEDI--VLNPEKVKQ 685
Query: 664 L 664
L
Sbjct: 686 L 686
>HELS_SULSO (Q97VY9) Putative ski2-type helicase (EC 3.6.1.-)
Length = 708
Score = 135 bits (339), Expect = 1e-30
Identities = 100/328 (30%), Positives = 161/328 (48%), Gaps = 47/328 (14%)
Query: 44 KDTSVAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAA 103
K+ + + T EK +SL L+E V+DELH + DP+RG ++E + +
Sbjct: 113 KNYDIIITTYEKLDSLWRH--RPDWLNEANYFVLDELHYLNDPERGPVVESVTIR----- 165
Query: 104 GEGISKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLE 163
A+ ++ +SAT+ N +A WL A T +RPVPL
Sbjct: 166 ----------------------AKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLM 203
Query: 164 EYIKVGNSIYNKSMELSRTIPKGADLGGK--DPDHVVELCNEVVQEGQSVLIFCSSRKGC 221
E + +Y + + TI + K D ++ + + + VL+F +SRK
Sbjct: 204 EGV-----MYPERKKKEYTILFRDNTARKVHGDDAIIAYTLDSLSKNGQVLVFRNSRKMA 258
Query: 222 ESTARHVAKFLKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAG 281
ESTA +A ++ ++D ++I ++ + + + +L+ GVA+HHAG
Sbjct: 259 ESTALKIANYMNFVSLDEKA----ISEILKQLDDIEEGGSDEKELLKSLISKGVAYHHAG 314
Query: 282 LTVEEREIVETCYRKGLLRVLTATSTLAAGVNLPARRVI------FRQPRIG-CDFIDGT 334
L+ R+I+E +RK ++V+ AT TLAAGVNLPAR VI F + +G D I
Sbjct: 315 LSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVM 374
Query: 335 RYMQMAGRAGRTGIDTKGESVLICKPQE 362
Y QM+GRAGR G D GES+++ + +E
Sbjct: 375 EYKQMSGRAGRPGFDQIGESIIVVRDKE 402
Score = 33.5 bits (75), Expect = 4.8
Identities = 24/96 (25%), Positives = 40/96 (41%)
Query: 552 VALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRFASMVAVFCERLGWHDFEGLVAK 611
VALI+ + E + + + G ++ + E + L D +
Sbjct: 577 VALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDDHSDKLRI 636
Query: 612 FQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLR 647
RV+ GV+ E++EL I V RAR LY G++
Sbjct: 637 LNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIK 672
>HELS_METTH (O26901) Putative ski2-type helicase (EC 3.6.1.-)
Length = 690
Score = 130 bits (328), Expect = 2e-29
Identities = 120/415 (28%), Positives = 187/415 (44%), Gaps = 63/415 (15%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKDTSVAVCTIEKANSLINR 62
I +P +SI EK + KL E G V G P+ + +AV E +SL
Sbjct: 70 IYTVPLLSIQNEKIKEFRKL-EEHGIRV---------GKDPRTSDIAVMVFESFDSLTR- 118
Query: 63 LLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSSDK 122
L E+ ++++DE HM+G+ RG ++E +T+ R
Sbjct: 119 -FSWNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTL-------------------- 157
Query: 123 NDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKSMELSRT 182
+P+ ++IV +SAT+ N+ +A WL A + + ++RPVPL + E+
Sbjct: 158 -NPS--VRIVALSATLSNMDEIAGWLDARVVEHDYRPVPLHREV--------LDTEMFGV 206
Query: 183 IPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVA-KFLKSFTVDINE 241
K D V+++ +++G L F S+R+ ES A H+A K D+ E
Sbjct: 207 REKN--------DVVLKVLERSLEDGSQTLAFVSTRRFTESLASHLADKISGKIPDDMVE 258
Query: 242 NNCEFA-DITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRKGLLR 300
+ E A + S P L E AG+AFHHAGL +REI+E +R G +
Sbjct: 259 SFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGLFNRQREIIEDEFRDGNIL 318
Query: 301 VLTATSTLAAGVNLPARRVIFRQ----PRIGCDFIDGTRYMQMAGRAGRTGIDTKGESVL 356
++TAT +L GVNLP+R V+ R G I Y QM+GRAGR D G S L
Sbjct: 319 MITATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQMSGRAGRPQYDDAGYSYL 378
Query: 357 ICKPQELKKVMGL----LNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQTANDI 407
I + + + M L + S + E+ + + I+ VA G+ T ++
Sbjct: 379 IARSHD--EAMDLEEYYIRGEVERTTSRIIENRDALYRQIIAQVASGLSGTTEEL 431
>HELS_PYRFU (O73946) Putative ski2-type helicase (EC 3.6.1.-)
Length = 720
Score = 125 bits (313), Expect = 1e-27
Identities = 113/416 (27%), Positives = 186/416 (44%), Gaps = 63/416 (15%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKDT-----SVAVCTIEKA 56
A+ ++P ++ EK + + E +G V G+ KD + + T EK
Sbjct: 71 AVYIVPLKALAEEKFQEFQDW-EKIGLRVAMATGDYDS----KDEWLGKYDIIIATAEKF 125
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+SL+ + ++ I+V DE+H++G RG LE++L + A
Sbjct: 126 DSLLRH--GSSWIKDVKILVADEIHLIGSRDRGATLEVILAHMLGKA------------- 170
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQTEFRPVPLEEYIKVGNSIYNKS 176
QI+G+SAT+ N +A+WL A L +++RPV L + + +
Sbjct: 171 -------------QIIGLSATIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWED 217
Query: 177 MELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKFLKSFT 236
+ R EL + +++ + LIF + R+ E A ++K +KS
Sbjct: 218 GSIDRF------------SSWEELVYDAIRKKKGALIFVNMRRKAERVALELSKKVKSLL 265
Query: 237 VDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETCYRK 296
E + +SL + P + L + GVAFHHAGL +ER +VE +RK
Sbjct: 266 T-----KPEIRALNELADSLEENPT--NEKLAKAIRGGVAFHHAGLGRDERVLVEENFRK 318
Query: 297 GLLRVLTATSTLAAGVNLPARRV----IFRQPRIGCDFIDGTRYMQMAGRAGRTGIDTKG 352
G+++ + AT TL+AG+N PA RV I+R G + I QM GRAGR D G
Sbjct: 319 GIIKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPIIEVHQMLGRAGRPKYDEVG 378
Query: 353 ESVLICKPQELKKVMGLLNESCP-PLHSCLSEDLNGMTHAILEVVAGGIVQTANDI 407
E +++ + ++VM P L S LS + N + +L ++A T +I
Sbjct: 379 EGIIVSTSDDPREVMNHYIFGKPEKLFSQLSNESN-LRSQVLALIATFGYSTVEEI 433
Score = 62.4 bits (150), Expect = 1e-08
Identities = 36/115 (31%), Positives = 59/115 (51%)
Query: 548 KRFYVALILSLLVQETPVGEVCEAFKVARGMVQGLQENAGRFASMVAVFCERLGWHDFEG 607
+ F AL+L + E P GE+ E + V G + + E A + + LG ++
Sbjct: 569 RAFKTALVLLAWINEVPEGEIVEKYSVEPGDIYRIVETAEWLVYSLKEIAKVLGAYEIVD 628
Query: 608 LVAKFQNRVSFGVRAEVVELTTIPYVKGSRARALYKAGLRTPLAIAEASIPELVK 662
+ + RV +G+R E++ L +P V RARALY +G R+ I++A EL+K
Sbjct: 629 YLETLRVRVKYGIREELIPLMQLPLVGRRRARALYNSGFRSIEDISQARPEELLK 683
>BRR2_YEAST (P32639) Pre-mRNA splicing helicase BRR2 (EC 3.6.1.-)
(Protein Snu246)
Length = 2163
Score = 121 bits (303), Expect = 2e-26
Identities = 124/439 (28%), Positives = 195/439 (44%), Gaps = 71/439 (16%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKD-TSVAVCTIEKANSLIN 61
+ + P ++ E+ ++ L LG V G+ D T V V T EK +
Sbjct: 558 VYIAPLKALVQEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTR 617
Query: 62 RLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSSD 121
+ + +++IDE+H++ D RG +LE ++ + +A+ G
Sbjct: 618 NSNNLAIVELVRLLIIDEIHLLHDD-RGPVLESIVARTFWASKYG--------------- 661
Query: 122 KNDPAQGLQIVGMSATMPNVAAVADWLQAA-----LYQTEFRPVPLEEY---IKVGNSIY 173
+ +I+G+SAT+PN V +L+ + + FRP PL + IK NS+
Sbjct: 662 ----QEYPRIIGLSATLPNYEDVGRFLRVPKEGLFYFDSSFRPCPLSQQFCGIKERNSLK 717
Query: 174 N-KSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVA-KF 231
K+M D E E + EG +++F SRK TA + KF
Sbjct: 718 KLKAMN----------------DACYEKVLESINEGNQIIVFVHSRKETSRTATWLKNKF 761
Query: 232 LK-SFTVDINENNCEFADI--TSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEERE 288
+ + T + +N+ I T A N L DP L + +G+ HHAGLT +R
Sbjct: 762 AEENITHKLTKNDAGSKQILKTEAANVL-------DPSLRKLIESGIGTHHAGLTRSDRS 814
Query: 289 IVETCYRKGLLRVLTATSTLAAGVNLPARRVIFR-----QPRIGC-DFIDGTRYMQMAGR 342
+ E + GLL+VL T+TLA GVNLPA VI + P G + + +QM GR
Sbjct: 815 LSEDLFADGLLQVLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQMLGR 874
Query: 343 AGRTGIDTKGESVLICKPQELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQ 402
AGR DT GE ++I ++ + +LN+ P +S+ ++ + EVVAG I +
Sbjct: 875 AGRPRYDTFGEGIIITDQSNVQYYLSVLNQQLPIESQFVSKLVDNLN---AEVVAGNI-K 930
Query: 403 TANDIHRKFLEWNEDTKLY 421
ND + W T LY
Sbjct: 931 CRNDA----VNWLAYTYLY 945
>U520_HUMAN (O75643) U5 small nuclear ribonucleoprotein 200 kDa
helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa
protein) (U5-200KD) (Activating signal cointegrator 1
complex subunit 3-like 1) (Fragment)
Length = 1701
Score = 117 bits (293), Expect = 3e-25
Identities = 124/422 (29%), Positives = 192/422 (45%), Gaps = 63/422 (14%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKD----TSVAVCTIEKANS 58
I + P S+ E K L G V G+ L K+ T + VCT EK +
Sbjct: 104 IYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH---QLCKEEISATQIIVCTPEKWDI 160
Query: 59 LINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGG 118
+ + E + +IV+DE+H++ D RG +LE ++ + A I + +
Sbjct: 161 ITRKGGERTYTQLVRLIVLDEIHLLHDD-RGPVLEALVAR----AIRNIEMTQED----- 210
Query: 119 SSDKNDPAQGLQIVGMSATMPNVAAVADWLQAA------LYQTEFRPVPLEE-YIKVGNS 171
++++G+SAT+PN VA +L+ + FRPVPLE+ Y+ +
Sbjct: 211 ----------VRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEK 260
Query: 172 IYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKF 231
K ++ I V E E + Q VL+F SRK TAR +
Sbjct: 261 KAIKRFQIMNEI-------------VYEKIMEHAGKNQ-VLVFVHSRKETGKTARAIRDM 306
Query: 232 -LKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIV 290
L+ T+ + E + T + + + L+ L++ P G A HHAG+T +R +V
Sbjct: 307 CLEKDTLGLFLR--EGSASTEVLRTEAEQCKNLE--LKDLLPYGFAIHHAGMTRVDRTLV 362
Query: 291 ETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRI------GCDFIDGTRYMQMAGRAG 344
E + ++VL +T+TLA GVNLPA VI + ++ + +QM GRAG
Sbjct: 363 EDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAG 422
Query: 345 RTGIDTKGESVLICKPQELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIVQTA 404
R DTKGE +LI EL+ + LLN+ P+ S + L M +A E+V G VQ A
Sbjct: 423 RPQYDTKGEGILITSHGELQYYLSLLNQQL-PIESQMVSKLPDMLNA--EIVLGN-VQNA 478
Query: 405 ND 406
D
Sbjct: 479 KD 480
Score = 91.3 bits (225), Expect = 2e-17
Identities = 92/358 (25%), Positives = 156/358 (42%), Gaps = 61/358 (17%)
Query: 47 SVAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEG 106
++ + T EK + L R + + + + V+DE+H++G + G +LE++ +++RY
Sbjct: 988 NIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGG-ENGPVLEVICSRMRYI---- 1042
Query: 107 ISKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAALYQT-----EFRPVP 161
SS P ++IV +S+++ N VA WL + T RPVP
Sbjct: 1043 ------------SSQIERP---IRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVP 1087
Query: 162 LEEYIKVGNSIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGC 221
LE +I+ N + ++ LS P + P + V++F SRK
Sbjct: 1088 LELHIQGFNISHTQTRLLSMAKPVFHAITKHSPK-------------KPVIVFVPSRKQT 1134
Query: 222 ESTARHVAKFLKSFTVDINEN---NCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFH 278
TA + L + DI +C D+ + L D L+ET GV +
Sbjct: 1135 RLTAIDI---LTTCAADIQRQRFLHCTEKDLIPYLEKLS------DSTLKETLLNGVGYL 1185
Query: 279 HAGLTVEEREIVETCYRKGLLRVLTATSTLAAGVNLPARRVI-----FRQPRIGCDFIDG 333
H GL+ ER +VE + G ++V+ A+ +L G+N+ A VI + +I ++D
Sbjct: 1186 HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHA-YVDY 1244
Query: 334 TRY--MQMAGRAGRTGIDTKGESVLICKPQELKKVMGLLNESCP---PLHSCLSEDLN 386
Y +QM G A R D +G V++C+ + L E P L C+ + N
Sbjct: 1245 PIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFN 1302
>K052_HUMAN (P42285) Protein KIAA0052 (Fragment)
Length = 1046
Score = 115 bits (289), Expect = 7e-25
Identities = 105/381 (27%), Positives = 167/381 (43%), Gaps = 72/381 (18%)
Query: 38 GGGSLPKDTSVAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLT 97
G ++ S V T E S++ R E R E+ ++ DE+H + D +RG + E +
Sbjct: 218 GDVTINPTASCLVMTTEILRSMLYRGSEVMR--EVAWVIFDEIHYMRDSERGVVWEETII 275
Query: 98 KLRYAAGEGISKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWL------QAA 151
L + V +SAT+PN A+W+
Sbjct: 276 LL--------------------------PDNVHYVFLSATIPNARQFAEWICHLHKQPCH 309
Query: 152 LYQTEFRPVPLEEYI-----------------------KVGNSIYNKSMELSRTIPKGAD 188
+ T++RP PL+ YI + + +L++ KG
Sbjct: 310 VIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRK 369
Query: 189 LGGKDPDHVVELCNEVVQEG-QSVLIFCSSRKGCESTARHVAKFLKSFTVDINENNCEFA 247
G K P +V ++ +++ Q V+IF S+K CE+ A + K F D + E
Sbjct: 370 GGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKL--DFNTDEEKKMVEEV 427
Query: 248 DITSAINSLRKCPAGLDPVLEETFPA---GVAFHHAGLTVEEREIVETCYRKGLLRVLTA 304
++AI+ L L P +E P G+ HH GL +E +E + +GL++ L A
Sbjct: 428 -FSNAIDCLSDEDKKL-PQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFA 485
Query: 305 TSTLAAGVNLPARRVIFRQPR--IGCDF--IDGTRYMQMAGRAGRTGIDTKGESVLICKP 360
T T A G+N+PAR V+F R G DF I Y+QM+GRAGR G+D +G V++
Sbjct: 486 TETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRG-IVILMVD 544
Query: 361 QELKKVMG--LLNESCPPLHS 379
+++ +G LL S PL+S
Sbjct: 545 EKMSPTIGKQLLKGSADPLNS 565
>U520_DROME (Q9VUV9) Putative U5 small nuclear ribonucleoprotein 200
kDa helicase (EC 3.6.1.-)
Length = 2142
Score = 114 bits (286), Expect = 2e-24
Identities = 109/371 (29%), Positives = 170/371 (45%), Gaps = 59/371 (15%)
Query: 46 TSVAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGE 105
T V VCT EK + + + E +S + +++IDE+H++ D +RG +LE ++ +
Sbjct: 583 TQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHD-ERGPVLEALVART------ 635
Query: 106 GISKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAA------LYQTEFRP 159
+ + +++VG+SAT+PN VA +L+ + +RP
Sbjct: 636 -------------IRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRP 682
Query: 160 VPLEE-YIKVGNSIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSR 218
V LE+ YI V K ++ I V E E Q VL+F SR
Sbjct: 683 VSLEQQYIGVTEKKALKRFQVMNEI-------------VYEKTMEHAGRNQ-VLVFVHSR 728
Query: 219 KGCESTARHVAKF-LKSFTVD--INENNCEFADITSAINSLRKCPAGLDPVLEETFPAGV 275
K TAR V L+ T+ + E + + + ++ L+E P G
Sbjct: 729 KETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQVKNTE------LKELLPYGF 782
Query: 276 AFHHAGLTVEEREIVETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRI------GCD 329
A HHAG+T +R +VE + ++VL +T+TLA GVNLPA VI + ++
Sbjct: 783 AIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWV 842
Query: 330 FIDGTRYMQMAGRAGRTGIDTKGESVLICKPQELKKVMGLLNESCPPLHSCLSEDLNGMT 389
+ +QM GRAGR DTKGE +LI EL+ + LLN+ P+ S L M
Sbjct: 843 ELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQL-PIESQFISKLPDML 901
Query: 390 HAILEVVAGGI 400
+A E+V G +
Sbjct: 902 NA--EIVLGTV 910
Score = 86.3 bits (212), Expect = 6e-16
Identities = 84/348 (24%), Positives = 150/348 (42%), Gaps = 68/348 (19%)
Query: 48 VAVCTIEKANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGI 107
+ + T +K + L R + + + + ++DEL +VG + G +LE++ +++RY + + I
Sbjct: 1423 LVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQLVGG-EEGPVLEIVCSRMRYISSQ-I 1480
Query: 108 SKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWL-----QAALYQTEFRPVPL 162
K ++IV +SA++ + VA WL + RP+PL
Sbjct: 1481 EKQ------------------IRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIPL 1522
Query: 163 EEYIKVGNSIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEG--QSVLIFCSSRKG 220
E +I+ N +N + + + P + N +++ + V++F SSRK
Sbjct: 1523 ELHIQGYNVTHNATRIATMSKP---------------VYNAILKYSAHKPVIVFVSSRKQ 1567
Query: 221 CESTARHVAKFLKSFTVDINEN---NCEFADITSAINSLRKCPAGLDPVLEETFPAGVAF 277
TA V + S D+ N + E DI + + D L+ET GVA+
Sbjct: 1568 ARLTAIDVLTYAAS---DLQPNRFFHAEEEDIKPFLERMT------DKTLKETLAQGVAY 1618
Query: 278 HHAGLTVEEREIVETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRIGCDFIDG---- 333
H GL+ + +VE + G ++V + L G+++ A VI + F +G
Sbjct: 1619 LHEGLSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVII----MDTQFYNGKNHS 1674
Query: 334 ------TRYMQMAGRAGRTGIDTKGESVLICKPQELKKVMGLLNESCP 375
T +QM GRA R D + VL+C+ + +NE P
Sbjct: 1675 YEDYPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKKFINEPLP 1722
>U520_CAEEL (Q9U2G0) Putative U5 small nuclear ribonucleoprotein 200
kDa helicase (EC 3.6.1.-)
Length = 2145
Score = 112 bits (280), Expect = 8e-24
Identities = 114/415 (27%), Positives = 182/415 (43%), Gaps = 61/415 (14%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKD----TSVAVCTIEKANS 58
+ + P S+ E K L P G V G+ + K+ T V VCT EK +
Sbjct: 533 VYIAPMKSLVQEMVGSFSKRLAPFGITVGEMTGD---AQMSKEQFMATQVIVCTPEKYDV 589
Query: 59 LINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGG 118
+ + E + +++IDE+H++ D + L +++ +R
Sbjct: 590 VTRKGGERAYNQMVRLLIIDEIHLLHDDRGPVLESIVVRTIRQM---------------- 633
Query: 119 SSDKNDPAQGLQIVGMSATMPNVAAVADWLQAA-----LYQTEFRPVPLEE-YIKVGNSI 172
+D + +VG+SAT+PN VA +L+ + +RPVPLE+ YI V
Sbjct: 634 -EQNHDECR---LVGLSATLPNYQDVATFLRVKPEHLHFFDNSYRPVPLEQQYIGVTEKK 689
Query: 173 YNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKF- 231
K + + D ++E + VL+F SRK TA+ +
Sbjct: 690 ALKRFQAMNEVVY---------DKIMEHAGK-----SQVLVFVHSRKETAKTAKAIRDAC 735
Query: 232 LKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVE 291
L+ T+ E + T + + + LD L++ P G A HHAG+ +R +VE
Sbjct: 736 LEKDTLSAFMR--EGSASTEILRTEAEQAKNLD--LKDLLPYGFAIHHAGMNRVDRTLVE 791
Query: 292 TCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRI------GCDFIDGTRYMQMAGRAGR 345
+ ++VL +T+TLA GVNLPA VI + +I + MQM GRAGR
Sbjct: 792 DLFADRHIQVLFSTATLAWGVNLPAHTVIIKGTQIYNPEKGRWTELGALDIMQMLGRAGR 851
Query: 346 TGIDTKGESVLICKPQELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGI 400
D +GE +LI EL+ + L+N+ P+ S + L M +A EVV G +
Sbjct: 852 PQYDDRGEGILITNHSELQYYLSLMNQQL-PVESQMVSRLTDMLNA--EVVLGTV 903
Score = 50.1 bits (118), Expect = 5e-05
Identities = 77/406 (18%), Positives = 152/406 (36%), Gaps = 60/406 (14%)
Query: 2 AILVLPYVSICTEKAEHLEKLLEP-LGKHVRSYYGNQGGG-SLPKDTSVAVCTIEKANSL 59
A+ + P + T+ ++ LEP +G + G Q L + + + T E+ +++
Sbjct: 1370 AVYITPMEDMATKVYADWKRRLEPAIGHTIVLLTGEQTMDLKLAQRGQLIISTPERWDNI 1429
Query: 60 INRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGS 119
R + + + + + D+LHM+G G + E++ ++ RY + + S
Sbjct: 1430 SRRWKQRKSVQNVKLFIADDLHMIG-ASNGAVFEVVCSRTRYISSQLES----------- 1477
Query: 120 SDKNDPAQGLQIVGMSATMPNVAAVADWLQAAL-----YQTEFRPVPLEEYIKVGNSIYN 174
+++V +S+++ N + WL + + RPVPL+ IK N +N
Sbjct: 1478 --------AVRVVALSSSLTNARDLGMWLGCSASATFNFMPSTRPVPLDLEIKSFNLSHN 1529
Query: 175 KSMELSRTIPKGADLGGKDPDHVVELCNEVVQ-EGQSVLIFCSSRKGCESTARHVAKFLK 233
S + P +C + E + L+F R+ A VA
Sbjct: 1530 ASRFAAMERPV-----------YQAICRHAGKLEPKPALVFVPVRRQTRPVA--VALLTM 1576
Query: 234 SFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVETC 293
+ + A+ +L D L E+ GV F H G ++ IV+
Sbjct: 1577 ALADGAPKRFLRLAEHDDTFQALLADIE--DESLRESVSCGVGFLHEGTAPKDVHIVQQL 1634
Query: 294 YRKGLLRVLTATSTLAAGVNLPARRVIFRQPRIGCDFIDGTRY----------MQMAGRA 343
+ ++V + + + A V+ + F +G + + M G A
Sbjct: 1635 FESNAIQVCVVPRGMCYQIEMSAYLVVV----MDTQFYNGKYHVYEDYPIADMLHMVGLA 1690
Query: 344 GRTGIDTKGESVLICKPQELKKVMGLLNESCP---PLHSCLSEDLN 386
R +D+ + V++C+ + L + P L CL + N
Sbjct: 1691 NRPILDSDAKCVVMCQTSKRAYYKKFLCDPLPVESHLDHCLHDHFN 1736
>HEL1_HUMAN (Q8N3C0) Activating signal cointegrator 1 complex
subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200)
(Trip4 complex subunit p200) (Helicase, ATP binding 1)
Length = 2202
Score = 111 bits (277), Expect = 2e-23
Identities = 116/453 (25%), Positives = 196/453 (42%), Gaps = 71/453 (15%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGN-QGGGSLPKDTSVAVCTIEKANSLIN 61
+ V P ++ E ++ + LEPLG V+ G+ Q S T + V T EK + +
Sbjct: 534 VYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTR 593
Query: 62 RLLEEGRLSEM-GIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSGGSS 120
+ + + LS++ ++++DE+H++ + + L ++ LR
Sbjct: 594 KSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQV------------------ 635
Query: 121 DKNDPAQGLQIVGMSATMPNVAAVADWLQAALY------QTEFRPVPLEEYIKVGNSIYN 174
++I+G+SAT+PN VA +L Y FRPVPL + +G N
Sbjct: 636 --ESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTF-LGIKCAN 692
Query: 175 KSMELSRTIPKGADLGGKDPDHVVELCNE----VVQEGQSVLIFCSSRKGCESTARHVAK 230
K +L+ ++ E+C E V+ G V++F +R TA + +
Sbjct: 693 KMQQLN---------------NMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLIE 737
Query: 231 FLKSFTVDINENNCEFADITSA---INSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEER 287
K N + F T + + ++ + + E FP G + HHAG+ ++R
Sbjct: 738 RAK------NCGHIPFFFSTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDR 791
Query: 288 EIVETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRIGC----DFID--GTRYMQMAG 341
+VE + G ++VL T+TLA GVNLPA VI + +I F+D MQ+ G
Sbjct: 792 NLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFG 851
Query: 342 RAGRTGIDTKGESVLICKPQELKKVMGLLNESCPPLHSCLSEDLNGMTHAILEVVAGGIV 401
RAGR D GE ++I +L + LL + P+ S E L +A E+ G +
Sbjct: 852 RAGRPQFDKFGEGIIITTHDKLSHYLTLLTQR-NPIESQFLESLADNLNA--EIALGTVT 908
Query: 402 QTANDIHRKFLEWNEDTKLYSTTPLGRASFGSS 434
+ ++W T LY ++G S
Sbjct: 909 NV-----EEAVKWISYTYLYVRMRANPLAYGIS 936
Score = 108 bits (271), Expect = 9e-23
Identities = 117/429 (27%), Positives = 189/429 (43%), Gaps = 78/429 (18%)
Query: 2 AILVLPYVSICTEKAEHLE-KLLEPLGKHVRSYYGNQGGGSLPKDTSVA-----VCTIEK 55
A+ + P ++ E+ + + ++ E LGK V G+ P S+A V T EK
Sbjct: 1375 AVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDV----TPDMKSIAKADLIVTTPEK 1430
Query: 56 ANSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEG 115
+ + + ++ I++IDE+H++G+ +RG +LE+++++ +
Sbjct: 1431 WDGVSRSWQNRNYVQQVTILIIDEIHLLGE-ERGPVLEVIVSRTNFI------------- 1476
Query: 116 SGGSSDKNDPAQGLQIVGMSATMPNVAAVADWL---QAALY--QTEFRPVPLEEYIKVGN 170
SS P ++IVG+S + N +ADWL Q L+ + RPVPLE +I+
Sbjct: 1477 ---SSHTEKP---VRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFP 1530
Query: 171 SIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAK 230
+ S P + P + VLIF SSR+ TA +
Sbjct: 1531 GQHYCPRMASMNKPAFQAIRSHSP-------------AKPVLIFVSSRRQTRLTALELIA 1577
Query: 231 FLKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIV 290
FL + N + ++ + I ++R D L+ T G+ HHAGL +R+ V
Sbjct: 1578 FLATEEDPKQWLNMDEREMENIIATVR------DSNLKLTLAFGIGMHHAGLHERDRKTV 1631
Query: 291 ETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRIGCDFIDG----------TRYMQMA 340
E + ++VL ATSTLA GVN PA VI + G ++ DG T +QM
Sbjct: 1632 EELFVNCKVQVLIATSTLAWGVNFPAHLVIIK----GTEYYDGKTRRYVDFPITDVLQMM 1687
Query: 341 GRAGRTGIDTKGESVLICKPQELKKVMGLLNESCP---PLHSCLSEDLNGMTHAILEVVA 397
GRAGR D +G++V++ + L E P L LS+ LN +A
Sbjct: 1688 GRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNA-------EIA 1740
Query: 398 GGIVQTAND 406
GG + + D
Sbjct: 1741 GGTITSKQD 1749
>HFM1_YEAST (P51979) ATP-dependent DNA helicase MER3 (EC 3.6.1.-)
(HFM1 protein)
Length = 1188
Score = 107 bits (266), Expect = 3e-22
Identities = 96/328 (29%), Positives = 151/328 (45%), Gaps = 67/328 (20%)
Query: 44 KDTSVAVCTIEKANSLINRLLEEGRLSEM-GIIVIDELHMVGDPKRGYLLELMLTKLRYA 102
K ++ + T EK + L R + RL E+ ++++DE+H + + KRG LE++LT++
Sbjct: 232 KKCNIIITTPEKWDLLTRRWSDYSRLFELVKLVLVDEIHTIKE-KRGASLEVILTRM--- 287
Query: 103 AGEGISKSSDGEGSGGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQA--------ALYQ 154
N Q ++ V +SAT+PN+ +A WL+ +
Sbjct: 288 --------------------NTMCQNIRFVALSATVPNIEDLALWLKTNNELPANILSFD 327
Query: 155 TEFRPVPLEEYIKVGNSIYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIF 214
+R V L +++ Y S K A K ++E+ E + + VLIF
Sbjct: 328 ESYRQVQLTKFV------YGYSFNCKNDFQKDAIYNSK----LIEII-EKHADNRPVLIF 376
Query: 215 CSSRKGCESTARHVAKFLKSFTVDINENNCEFADITSAINSLRKCPAG-LDPVLEETFPA 273
C +R STA KFL NN F+ S ++C D +L E
Sbjct: 377 CPTRASTISTA----KFLL--------NNHIFS------KSKKRCNHNPSDKILNECMQQ 418
Query: 274 GVAFHHAGLTVEEREIVETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPR----IGCD 329
G+AFHHAG+++E+R VE + G + +L +TSTLA GVNLPA VI + +
Sbjct: 419 GIAFHHAGISLEDRTAVEKEFLAGSINILCSTSTLAVGVNLPAYLVIIKGTKSWNSSEIQ 478
Query: 330 FIDGTRYMQMAGRAGRTGIDTKGESVLI 357
+QM GRAGR +T G +V++
Sbjct: 479 EYSDLDVLQMIGRAGRPQFETHGCAVIM 506
>YG5O_YEAST (P53327) Probable helicase YGR271W (EC 3.6.1.-)
Length = 1967
Score = 106 bits (264), Expect = 6e-22
Identities = 110/434 (25%), Positives = 182/434 (41%), Gaps = 73/434 (16%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPL-GKHVRSYYGNQGGGSLPK-----DTSVAVCTIEKA 56
+ + P ++ E+ + K + P+ G V G+ SLP D ++ + T EK
Sbjct: 1189 VYIAPMKALVRERVDDWRKKITPVTGDKVVELTGD----SLPDPKDVHDATIVITTPEKF 1244
Query: 57 NSLINRLLEEGRLSEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGS 116
+ + + ++ +I++DE+H++ RG +LE++++++ Y + +
Sbjct: 1245 DGISRNWQTRKFVQDVSLIIMDEIHLLASD-RGPILEMIVSRMNYISSQ----------- 1292
Query: 117 GGSSDKNDPAQGLQIVGMSATMPNVAAVADWLQA---ALYQ--TEFRPVPLEEYIKVGNS 171
Q ++++GMS + N +A WL LY + RPVPL+ YI G
Sbjct: 1293 --------TKQPVRLLGMSTAVSNAYDMAGWLGVKDHGLYNFPSSVRPVPLKMYID-GFP 1343
Query: 172 IYNKSMELSRTIPKGADLGGKD--PDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVA 229
L +T+ K + K PD + LIF +SR+ TA +
Sbjct: 1344 DNLAFCPLMKTMNKPVFMAIKQHSPD-------------KPALIFVASRRQTRLTALDLI 1390
Query: 230 KFLKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREI 289
+ +N F +I D L+ + G+ HHAGL ++R I
Sbjct: 1391 HLC-----GMEDNPRRFLNIDDEEELQYYLSQVTDDTLKLSLQFGIGLHHAGLVQKDRSI 1445
Query: 290 VETCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRI------GCDFIDGTRYMQMAGRA 343
++K +++L ATSTLA GVNLPA VI + + G +D T +QM GRA
Sbjct: 1446 SHQLFQKNKIQILIATSTLAWGVNLPAHLVIIKGTQFFDAKIEGYRDMDLTDILQMMGRA 1505
Query: 344 GRTGIDTKGESVLICKPQELKKVMGLLNESCP---PLHSCLSEDLNGMTHAILEVVAGGI 400
GR DT G +++ K + LN P LH L + L E+ +G I
Sbjct: 1506 GRPAYDTTGTAIVYTKESKKMFYKHFLNVGFPVESSLHKVLDDHLGA------EITSGSI 1559
Query: 401 VQTANDIHRKFLEW 414
+ FL W
Sbjct: 1560 TNKQEAL--DFLSW 1571
Score = 102 bits (253), Expect = 1e-20
Identities = 103/391 (26%), Positives = 167/391 (42%), Gaps = 56/391 (14%)
Query: 3 ILVLPYVSICTEKAEHLEKLLEPLGKHVRSYYGNQGGGSLPKD----TSVAVCTIEKANS 58
I V P ++ E + K L P VR G+ L K T V V T EK +
Sbjct: 350 IYVAPLKALAAEIVDKFSKKLAPFNIQVRELTGDM---QLTKAEILATQVIVTTPEKWDV 406
Query: 59 LINRLLEEGRL-SEMGIIVIDELHMVGDPKRGYLLELMLTKLRYAAGEGISKSSDGEGSG 117
+ + + L S++ +++IDE+H++ + + + L+ LR S+S
Sbjct: 407 VTRKANGDNDLVSKVKLLIIDEVHLLHEDRGPVIETLVARTLRQVES---SQSM------ 457
Query: 118 GSSDKNDPAQGLQIVGMSATMPNVAAVADWLQAA------LYQTEFRPVPLEEYIKVGNS 171
++I+G+SAT+PN VAD+L + FRP PLE+ + +G
Sbjct: 458 -----------IRIIGLSATLPNFMDVADFLGVNRQIGMFYFDQSFRPKPLEQQL-LGCR 505
Query: 172 IYNKSMELSRTIPKGADLGGKDPDHVVELCNEVVQEGQSVLIFCSSRKGCESTARHVAKF 231
S + I K A + +E++Q G V++F SRK +AR+ K
Sbjct: 506 GKAGSRQSKENIDKVA----------YDKLSEMIQRGYQVMVFVHSRKETVKSARNFIKL 555
Query: 232 LKSFTVDINENNCEFADITSAINSLRKCPAGLDPVLEETFPAGVAFHHAGLTVEEREIVE 291
+S +E + D R D ++E F G HHAG+ +R + E
Sbjct: 556 AESN----HEVDLFAPDPIEKDKYSRSLVKNRDKDMKEIFQFGFGIHHAGMARSDRNLTE 611
Query: 292 TCYRKGLLRVLTATSTLAAGVNLPARRVIFRQPRI------GCDFIDGTRYMQMAGRAGR 345
++ G ++VL T+TLA GVNLPA VI + ++ G + + +Q+ GR GR
Sbjct: 612 KMFKDGAIKVLCCTATLAWGVNLPADCVIIKGTQVYDSKKGGFIDLGISDVIQIFGRGGR 671
Query: 346 TGI-DTKGESVLICKPQELKKVMGLLNESCP 375
G G +L L + L+ + P
Sbjct: 672 PGFGSANGTGILCTSNDRLDHYVSLITQQHP 702
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.320 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 184,678,640
Number of Sequences: 164201
Number of extensions: 7855860
Number of successful extensions: 19560
Number of sequences better than 10.0: 122
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 19121
Number of HSP's gapped (non-prelim): 287
length of query: 1603
length of database: 59,974,054
effective HSP length: 124
effective length of query: 1479
effective length of database: 39,613,130
effective search space: 58587819270
effective search space used: 58587819270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Medicago: description of AC127429.13