BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC126018.1 + phase: 0 /pseudo
         (596 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom...   101  6e-21
ADP1_YEAST (P25371) Probable ATP-dependent permease precursor          96  3e-19
PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin              95  5e-19
PDRF_YEAST (Q04182) ATP-dependent permease PDR15                       92  5e-18
PDRA_YEAST (P51533) ATP-dependent permease PDR10                       90  1e-17
ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1...    88  7e-17
ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1...    86  2e-16
BFR1_SCHPO (P41820) Brefeldin A resistance protein                     82  5e-15
SNQ2_YEAST (P32568) SNQ2 protein                                       78  6e-14
CDR1_CANAL (P43071) Multidrug resistance protein CDR1                  78  6e-14
YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W         77  1e-13
CDR4_CANAL (O74676) ABC transporter CDR4                               77  2e-13
CDR2_CANAL (P78595) Multidrug resistance protein CDR2                  76  3e-13
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3               75  4e-13
ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4       74  8e-13
PDRC_YEAST (Q02785) ATP-dependent permease PDR12                       72  5e-12
YQ5C_CAEEL (Q09466) Putative ABC transporter C16C10.12 in chromo...    69  3e-11
PDRB_YEAST (P40550) ATP-dependent permease PDR11                       65  4e-10
AUS1_YEAST (Q08409) ATP-dependent permease AUS1                        65  4e-10
ABG3_MOUSE (Q99P81) ATP-binding cassette, sub-family G, member 3       64  9e-10

>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
           (Pleomorphic drug resistance homolog)
          Length = 1542

 Score =  101 bits (251), Expect = 6e-21
 Identities = 58/142 (40%), Positives = 80/142 (55%), Gaps = 10/142 (7%)

Query: 241 ADSVTESSHGKKKGMVLPFEPHSITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFR 300
           ++S+T  S G    + L        + ++ Y V +  E++          +L  V G  +
Sbjct: 862 SESITSGSRGGSPQVGLSKSEAIFHWQNLCYDVPIKTEVRR---------ILNNVDGWVK 912

Query: 301 PGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARISGYCEHNDIH 360
           PG LTALMG SGAGKTTL+D LA R T G I GD+ V+G P +  +F+R  GYC+  D+H
Sbjct: 913 PGTLTALMGASGAGKTTLLDCLAERTTMGVITGDVMVNGRP-RDTSFSRSIGYCQQQDLH 971

Query: 361 SPHVTVHESLLYSAWLRLPSGV 382
               TV ESL +SA+LR PS V
Sbjct: 972 LKTATVRESLRFSAYLRQPSSV 993



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 37/127 (29%), Positives = 61/127 (47%), Gaps = 11/127 (8%)

Query: 273 VDMPVEM------KEQGVRE-DRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGR 325
           +++PV++      K +  RE D   +LK + G  +PG L  ++G  G+G TTL+  ++  
Sbjct: 149 LNLPVKLLNAVWRKARPARESDTFRILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISST 208

Query: 326 KTGGYIDGDIKVS-GYPKKQETFARISGYCEHN---DIHSPHVTVHESLLYSAWLRLPSG 381
             G  I  D  +S       E      G   +N   DIH PH+TV+++L+  A L+ P  
Sbjct: 209 THGFQISKDSVISYNGLTPNEIKKHYRGEVVYNAEADIHLPHLTVYQTLVTVARLKTPQN 268

Query: 382 VDSNTTK 388
                T+
Sbjct: 269 RVKGVTR 275



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 36/128 (28%), Positives = 58/128 (45%), Gaps = 6/128 (4%)

Query: 1   MALIAMTLFFRTEMHRNDQDDAGVYAGA-LFFTLVTMMFNGMSEISMTIAKLPVYYKQRD 59
           MA I  ++F++ +  +    D   + GA +FF ++   F+ + EI       P+  K R 
Sbjct: 532 MAFILGSMFYKIQ--KGSSADTFYFRGAAMFFAILFNAFSSLLEIFSLYEARPITEKHRT 589

Query: 60  LLFYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMFKQFR---CVVFHES 116
              Y   A A  S I +IP  ++   L+  + Y+++ F  + GR F  F      VF  S
Sbjct: 590 YSLYHPSADAFASVISEIPPKIVTAILFNIIFYFLVNFRRDAGRFFFYFLINVIAVFAMS 649

Query: 117 DGFRIVPS 124
             FR V S
Sbjct: 650 HLFRCVGS 657


>ADP1_YEAST (P25371) Probable ATP-dependent permease precursor
          Length = 1049

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 55/153 (35%), Positives = 90/153 (57%), Gaps = 8/153 (5%)

Query: 263 SITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVL 322
           +++F++I YSV     +   GV E    +L  +SG  +PG + A+MG SGAGKTTL+D+L
Sbjct: 383 TLSFENITYSVP---SINSDGVEE---TVLNEISGIVKPGQILAIMGGSGAGKTTLLDIL 436

Query: 323 AGRKTGGYIDGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
           A ++  G++ G IKV+G    +++F++I G+ + +D   P +TV E++L SA LRLP  +
Sbjct: 437 AMKRKTGHVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKAL 496

Query: 383 DSNTTKVSEHVLYSEWIWLHLLTLL--NEHDRG 413
                K   + +  E   + +   +  NE DRG
Sbjct: 497 SFEAKKARVYKVLEELRIIDIKDRIIGNEFDRG 529


>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
          Length = 1511

 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 51/102 (50%), Positives = 66/102 (64%), Gaps = 1/102 (0%)

Query: 281 EQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGY 340
           E  ++ +   +L  V G  +PG LTALMG SGAGKTTL+D LA R T G I GDI V+G 
Sbjct: 877 EVQIKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDILVNGI 936

Query: 341 PKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
           P + ++F R  GYC+  D+H    TV ESL +SA+LR P+ V
Sbjct: 937 P-RDKSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEV 977



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 40/134 (29%), Positives = 66/134 (48%), Gaps = 18/134 (13%)

Query: 268 DIVYS---VDMPVEMKEQGVRE-------DRLVLLKGVSGAFRPGVLTALMGVSGAGKTT 317
           D+ Y    V++P ++ + G+R+       +   +LK + G   PG L  ++G  G+G TT
Sbjct: 142 DVAYQSTVVNIPYKILKSGLRKFQRSKETNTFQILKPMDGCLNPGELLVVLGRPGSGCTT 201

Query: 318 LMDVLAGRKTGGYIDGDIKV--SGYPKK--QETFARISGYCEHNDIHSPHVTVHESLLYS 373
           L+  ++    G  +  D K+  SGY     ++ F     Y    D+H PH+TV E+L+  
Sbjct: 202 LLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADVHLPHLTVFETLVTV 261

Query: 374 AWLRLP----SGVD 383
           A L+ P     GVD
Sbjct: 262 ARLKTPQNRIKGVD 275



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 36/127 (28%), Positives = 54/127 (42%), Gaps = 4/127 (3%)

Query: 1   MALIAMTLFFRTEMHRNDQDDAGVYAGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDL 60
           MALI  ++FF+  M + D         A+FF ++   F+ + EI       P+  K R  
Sbjct: 533 MALILGSMFFKI-MKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTY 591

Query: 61  LFYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMFKQFR---CVVFHESD 117
             Y   A A  S + +IP  L+    +  + Y+++ F  N G  F         VF  S 
Sbjct: 592 SLYHPSADAFASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSH 651

Query: 118 GFRIVPS 124
            FR V S
Sbjct: 652 LFRCVGS 658


>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
          Length = 1529

 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 50/92 (54%), Positives = 60/92 (64%), Gaps = 1/92 (1%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARI 350
           +L  V G  +PG LTALMG SGAGKTTL+D LA R T G I G+I V G   + E+F R 
Sbjct: 902 ILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGNIFVDG-RLRDESFPRS 960

Query: 351 SGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
            GYC+  D+H    TV ESL +SA+LR PS V
Sbjct: 961 IGYCQQQDLHLKTATVRESLRFSAYLRQPSSV 992



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 32/106 (30%), Positives = 52/106 (48%), Gaps = 8/106 (7%)

Query: 286 EDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYI--DGDIKVSGYPKK 343
           ED   +LK + G   PG L  ++G  G+G TTL+  ++    G  I  D  +  +G    
Sbjct: 180 EDTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSS 239

Query: 344 --QETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLP----SGVD 383
             ++ +     Y   +DIH PH+TV+++L   A ++ P     GVD
Sbjct: 240 DIRKHYRGEVVYNAESDIHLPHLTVYQTLFTVARMKTPQNRIKGVD 285



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 28/108 (25%), Positives = 48/108 (43%), Gaps = 1/108 (0%)

Query: 1   MALIAMTLFFRTEMHRNDQDDAGVYAGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDL 60
           MA I  ++F++  M +ND         A+FF ++   F+ + EI       P+  K R  
Sbjct: 543 MAFILGSMFYKV-MKKNDTSTFYFRGAAMFFAILFNAFSCLLEIFSLYETRPITEKHRTY 601

Query: 61  LFYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMFKQF 108
             Y   A A  S + ++P  L+    +  + Y+++ F  N G  F  F
Sbjct: 602 SLYHPSADAFASVLSEMPPKLITAVCFNIIFYFLVDFRRNGGVFFFYF 649


>PDRA_YEAST (P51533) ATP-dependent permease PDR10
          Length = 1564

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 47/94 (50%), Positives = 61/94 (64%), Gaps = 1/94 (1%)

Query: 284  VREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKK 343
            ++  +  +L  V G  +PG LTAL+G SGAGKTTL+D LA R T G I GD+ V G P+ 
Sbjct: 934  IKNGKRRILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGLITGDVFVDGRPRD 993

Query: 344  QETFARISGYCEHNDIHSPHVTVHESLLYSAWLR 377
            Q +F R  GYC+  D+H    TV ESL +SA+LR
Sbjct: 994  Q-SFPRSIGYCQQQDLHLKTATVRESLRFSAYLR 1026



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 35/104 (33%), Positives = 52/104 (49%), Gaps = 8/104 (7%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGD--IKVSGYPKKQ--ET 346
           +LK + G   PG L  ++G  GAG TTL+  ++    G  I  D  I  +G+  K+    
Sbjct: 195 ILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHGFKISPDTIITYNGFSNKEIKNH 254

Query: 347 FARISGYCEHNDIHSPHVTVHESLLYSAWLRLP----SGVDSNT 386
           +     Y   +DIH PH+TV ++L   A L+ P     GVD +T
Sbjct: 255 YRGEVVYNAESDIHIPHLTVFQTLYTVARLKTPRNRIKGVDRDT 298


>ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1
           (White protein homolog) (ATP-binding cassette
           transporter 8)
          Length = 666

 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 52/130 (40%), Positives = 78/130 (60%), Gaps = 7/130 (5%)

Query: 263 SITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVL 322
           +I F D+ YSV      K++G +     LLKG+SG F  G L A+MG SGAGK+TLM++L
Sbjct: 76  NIEFKDLSYSVPEGPWWKKKGYK----TLLKGISGKFNSGELVAIMGPSGAGKSTLMNIL 131

Query: 323 AG-RKTGGYIDGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSG 381
           AG R+TG  + G + ++G P+    F ++S Y   +D+  PH+TV E+++ SA L+L   
Sbjct: 132 AGYRETG--MKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 189

Query: 382 VDSNTTKVSE 391
            +     V E
Sbjct: 190 DEGRREMVKE 199


>ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1
           (White protein homolog) (ATP-binding cassette
           transporter 8)
          Length = 678

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 51/130 (39%), Positives = 78/130 (59%), Gaps = 7/130 (5%)

Query: 263 SITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVL 322
           +I F D+ YSV      +++G +     LLKG+SG F  G L A+MG SGAGK+TLM++L
Sbjct: 76  NIEFRDLSYSVPEGPWWRKKGYK----TLLKGISGKFNSGELVAIMGPSGAGKSTLMNIL 131

Query: 323 AG-RKTGGYIDGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSG 381
           AG R+TG  + G + ++G P+    F ++S Y   +D+  PH+TV E+++ SA L+L   
Sbjct: 132 AGYRETG--MKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 189

Query: 382 VDSNTTKVSE 391
            +     V E
Sbjct: 190 DEGRREMVKE 199


>BFR1_SCHPO (P41820) Brefeldin A resistance protein
          Length = 1530

 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 47/92 (51%), Positives = 58/92 (62%), Gaps = 1/92 (1%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARI 350
           LL GV G   PG LTALMG SGAGKTTL++VLA R   G + GD+ V+G      TF R 
Sbjct: 900 LLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNG-RGLDSTFQRR 958

Query: 351 SGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
           +GY +  D+H    TV E+L +SA LR P+ V
Sbjct: 959 TGYVQQQDVHIGESTVREALRFSAALRQPASV 990



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 25/107 (23%), Positives = 50/107 (46%), Gaps = 3/107 (2%)

Query: 2   ALIAMTLFFRTEMHRNDQDDAGVYAGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDLL 61
           +LI  ++F+  +++  D    G   G LFF+++      +SEI+   ++ P+  K R   
Sbjct: 552 SLIIGSIFYDMKLNTVDVFSRG---GVLFFSILFCALQSLSEIANMFSQRPIIAKHRASA 608

Query: 62  FYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMFKQF 108
            Y   A  I S I+ +P   + +S++  + Y++       G  +  F
Sbjct: 609 LYHPAADVISSLIVDLPFRFINISVFSIVLYFLTNLKRTAGGFWTYF 655



 Score = 32.0 bits (71), Expect = 4.7
 Identities = 25/90 (27%), Positives = 41/90 (44%), Gaps = 3/90 (3%)

Query: 302 GVLTALMGVSGAGKTT-LMDVLAGRKTGGYIDGDIKVSGYPKK--QETFARISGYCEHND 358
           G L  ++G  G+G +T L  V +       ++G     G  K   ++ F     Y   ND
Sbjct: 187 GELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKKFFPGDLLYSGEND 246

Query: 359 IHSPHVTVHESLLYSAWLRLPSGVDSNTTK 388
           +H P +T  E+L ++A  R P+    N T+
Sbjct: 247 VHFPSLTTAETLDFAAKCRTPNNRPCNLTR 276


>SNQ2_YEAST (P32568) SNQ2 protein
          Length = 1501

 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 46/90 (51%), Positives = 58/90 (64%), Gaps = 2/90 (2%)

Query: 290 VLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFAR 349
           +LL  VSG   PG +TALMG SGAGKTTL++ LA R   G I GD+ V+G P    +F R
Sbjct: 870 MLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNV-GIITGDMLVNGRP-IDASFER 927

Query: 350 ISGYCEHNDIHSPHVTVHESLLYSAWLRLP 379
            +GY +  DIH   +TV ESL +SA +R P
Sbjct: 928 RTGYVQQQDIHIAELTVRESLQFSARMRRP 957


>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
          Length = 1501

 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 49/111 (44%), Positives = 71/111 (63%), Gaps = 5/111 (4%)

Query: 268 DIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKT 327
           +I +  D+  ++K +  +EDR V+L  V G  +PG +TALMG SGAGKTTL++ L+ R T
Sbjct: 857 EIFFWRDLTYQVKIK--KEDR-VILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVT 913

Query: 328 GGYI-DGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLR 377
            G I DG+  V+G+     +F R  GY +  D+H P  TV E+L +SA+LR
Sbjct: 914 TGIITDGERLVNGH-ALDSSFQRSIGYVQQQDVHLPTSTVREALQFSAYLR 963



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 35/104 (33%), Positives = 52/104 (49%), Gaps = 8/104 (7%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYI--DGDIKVSGY-PKKQETF 347
           +LK +    RPG LT ++G  GAG +TL+  +A    G +I  +  I   G  P   E  
Sbjct: 169 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 228

Query: 348 ARISG-YCEHNDIHSPHVTVHESLLYSAWLRLP----SGVDSNT 386
            R    Y    D+H PH++V ++L ++A LR P     G+D  T
Sbjct: 229 YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRET 272



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 27/104 (25%), Positives = 45/104 (42%), Gaps = 2/104 (1%)

Query: 4   IAMTLFFRTEMHRNDQDDAGVY--AGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDLL 61
           + M L   +  +   Q     Y    A+FF ++   F+ + EI       P+  K +   
Sbjct: 523 LVMGLILSSVFYNLSQTTGSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYA 582

Query: 62  FYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMF 105
            Y   A A+ S I ++PV L     + F+ Y+++ F  N GR F
Sbjct: 583 LYRPSADALASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFF 626


>YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W
          Length = 1333

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 45/92 (48%), Positives = 57/92 (61%), Gaps = 2/92 (2%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARI 350
           LL  VSG   PG LTAL+G SGAGKTTL++ LA R   G I GD+ V G P    +F R 
Sbjct: 747 LLDSVSGYCVPGTLTALIGESGAGKTTLLNTLAQRNV-GTITGDMLVDGLP-MDASFKRR 804

Query: 351 SGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
           +GY +  D+H   +TV ESL +SA +R P  +
Sbjct: 805 TGYVQQQDLHVAELTVKESLQFSARMRRPQSI 836



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/146 (26%), Positives = 72/146 (48%), Gaps = 7/146 (4%)

Query: 279 MKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKT---GGYIDGDI 335
           ++E+  R    ++LK VS   + G +  ++G  GAG T+ +   AG  +   GG   G I
Sbjct: 33  IRERKNRNKMKIILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHI 92

Query: 336 KVSGYPKKQ--ETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSGVDSNTTKVSEHV 393
              G P+K+  + +     Y    D+H PH+TV ++L ++   ++P+   +N TK  E++
Sbjct: 93  SYDGIPQKEMMQHYKPDVIYNGEQDVHFPHLTVKQTLDFAISCKMPAKRVNNVTK-EEYI 151

Query: 394 LYSEWIWLHLLTLLNEHD-RGGGRFI 418
             +   +  +  L +  D + G  FI
Sbjct: 152 TANREFYAKIFGLTHTFDTKVGNDFI 177


>CDR4_CANAL (O74676) ABC transporter CDR4
          Length = 1490

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 51/148 (34%), Positives = 77/148 (51%), Gaps = 12/148 (8%)

Query: 238 SGRADSVT---ESSHGKKKGMVLPFEPHSITFDDIVYSVDMPVEMKEQGVREDRLVLLKG 294
           SG  + VT   ++ +   +  +L     +  + D+ Y V +          EDR V+L  
Sbjct: 817 SGEIEKVTPEFDNEYENNQDKMLQSGGDTFFWRDLTYQVKIK--------SEDR-VILDH 867

Query: 295 VSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARISGYC 354
           VSG  +PG +TALMG SGAGKTTL++ L+ R T G +   I++        +F R  GY 
Sbjct: 868 VSGWVKPGQVTALMGASGAGKTTLLNALSDRLTTGVVTEGIRLVNGRPLDSSFQRSIGYV 927

Query: 355 EHNDIHSPHVTVHESLLYSAWLRLPSGV 382
           +  D+H    TV E+L ++A+LR P  V
Sbjct: 928 QQQDLHLETSTVREALEFAAYLRQPKSV 955



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 29/93 (31%), Positives = 51/93 (54%), Gaps = 4/93 (4%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKV---SGYPKK-QET 346
           +LK + G  +PG LT ++G  GAG +T +  +A +  G +ID D  +   S  P + ++ 
Sbjct: 172 ILKPMDGLIKPGELTVVLGRPGAGCSTFLKTIASQTYGYHIDKDSVIRYNSLTPHEIKKH 231

Query: 347 FARISGYCEHNDIHSPHVTVHESLLYSAWLRLP 379
           +     YC   + H P +TV ++L ++A +R P
Sbjct: 232 YRGEVVYCAETENHFPQLTVGDTLEFAAKMRTP 264


>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
          Length = 1499

 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 48/111 (43%), Positives = 70/111 (62%), Gaps = 5/111 (4%)

Query: 268 DIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKT 327
           +I +  D+  ++K +  +EDR V+L  V G  +PG +TALMG SGAGKTTL++ L+ R T
Sbjct: 855 EIFFWRDLTYQVKIK--KEDR-VILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVT 911

Query: 328 GGYI-DGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLR 377
            G I DG+  V+G+     +F R  GY +  D+H    TV E+L +SA+LR
Sbjct: 912 TGIITDGERLVNGH-ALDSSFQRSIGYVQQQDVHLETTTVREALQFSAYLR 961



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 35/104 (33%), Positives = 52/104 (49%), Gaps = 8/104 (7%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYI--DGDIKVSGY-PKKQETF 347
           +LK +    RPG LT ++G  GAG +TL+  +A    G +I  +  I   G  P   E  
Sbjct: 167 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 226

Query: 348 ARISG-YCEHNDIHSPHVTVHESLLYSAWLRLP----SGVDSNT 386
            R    Y    D+H PH++V ++L ++A LR P     G+D  T
Sbjct: 227 YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRET 270



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 3/105 (2%)

Query: 1   MALIAMTLFFRTEMHRNDQDDAGVYAGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDL 60
           M LI  ++FF     R   D      GALFF+++   F+ + EI       P+  K R  
Sbjct: 523 MGLILASVFFNL---RKSTDTFYFRGGALFFSVLFNAFSSLLEILSLYEARPIVEKHRKY 579

Query: 61  LFYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMF 105
             Y   A A+ S I ++PV L+    +  + Y+++      G  F
Sbjct: 580 ALYRPSADALASIISELPVKLLMTMSFNIVYYFMVNLRRTAGNFF 624


>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
          Length = 1501

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 39/99 (39%), Positives = 58/99 (58%)

Query: 284 VREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKK 343
           ++ +  V+L  + G  +PG +TALMG SGAGKTTL++ L+ R T G I    ++    + 
Sbjct: 851 IKSEERVILNNIDGWVKPGEVTALMGASGAGKTTLLNALSERLTTGVITSGTRMVNGGEL 910

Query: 344 QETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
             +F R  GY +  D+H    TV E+L +SA LR P+ V
Sbjct: 911 DSSFQRSIGYVQQQDLHLETSTVREALKFSARLRQPNSV 949



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 28/93 (30%), Positives = 50/93 (53%), Gaps = 4/93 (4%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYI-DGDIKVSGYPKKQETFAR 349
           +LK + G  +PG +T ++G  GAG +T +  +A R  G ++ DG +       + E    
Sbjct: 160 ILKPMEGLIKPGEVTVVLGRPGAGCSTFLKTIACRTEGFHVADGSVISYDGITQDEIRNH 219

Query: 350 ISG---YCEHNDIHSPHVTVHESLLYSAWLRLP 379
           + G   YC   + H P++TV E+L ++A ++ P
Sbjct: 220 LRGEVVYCAETETHFPNLTVGETLEFAALMKTP 252



 Score = 35.0 bits (79), Expect = 0.56
 Identities = 23/104 (22%), Positives = 44/104 (42%), Gaps = 2/104 (1%)

Query: 4   IAMTLFFRTEMHRNDQDDAGVY--AGALFFTLVTMMFNGMSEISMTIAKLPVYYKQRDLL 61
           IAM L   +  +    + +  Y     +++ L+   ++ + EI        +  K R+  
Sbjct: 514 IAMALILSSVFYNLQPNSSSFYYRTSVMYYALLFNAYSSVLEIYNMYEGRAIVQKHREYA 573

Query: 62  FYPSWAYAIPSWILKIPVSLMEVSLWVFLTYYVIGFDPNVGRMF 105
            YP  A AI S I   P+ ++   L+  + Y+++ F    G  F
Sbjct: 574 LYPPMADAIGSIISDFPLKVVCSVLFNLILYFMVNFKREPGAFF 617


>ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4
          Length = 646

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 55/161 (34%), Positives = 87/161 (53%), Gaps = 14/161 (8%)

Query: 234 TTYCSGRADSVTES---SHGKKKGMVLPFEPHSITFDDIVYSVDMPVEMKEQGVREDRLV 290
           TT+     + +TE+   SH  K+  V       I F ++ YSV      +++G +     
Sbjct: 34  TTHLKKVENHITEAQRFSHLPKRSAV------DIEFVELSYSVREGPCWRKRGYK----T 83

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARI 350
           LLK +SG F    L  +MG SGAGK+T M++LAG +  G + G I V+G P++  TF ++
Sbjct: 84  LLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESG-MKGQILVNGRPRELRTFRKM 142

Query: 351 SGYCEHNDIHSPHVTVHESLLYSAWLRLPSGVDSNTTKVSE 391
           S Y   +D+  PH+TV E+++ SA L+L    +     V+E
Sbjct: 143 SCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTE 183


>PDRC_YEAST (Q02785) ATP-dependent permease PDR12
          Length = 1511

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 44/92 (47%), Positives = 55/92 (58%), Gaps = 1/92 (1%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQETFARI 350
           LL  V G  +PG +TALMG SGAGKTTL++VLA R   G I GD+ V+  P    +F R 
Sbjct: 860 LLSDVFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGVITGDMLVNAKP-LPASFNRS 918

Query: 351 SGYCEHNDIHSPHVTVHESLLYSAWLRLPSGV 382
            GY    D H   ++V ESL ++A LR  S V
Sbjct: 919 CGYVAQADNHMAELSVRESLRFAAELRQQSSV 950



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 27/104 (25%), Positives = 50/104 (47%), Gaps = 8/104 (7%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYID--GDIKVSGYPKKQETFA 348
           +++  +G    G +  ++G  GAG +T +  L+G +T   +D  G+    G  +  E  +
Sbjct: 163 IIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSG-ETSELVDVQGEFSYDGLDQS-EMMS 220

Query: 349 RISGY---CEHNDIHSPHVTVHESLLYSAWLRLPS-GVDSNTTK 388
           +  GY   C   D H P +TV E++ ++   + P   +D  T K
Sbjct: 221 KYKGYVIYCPELDFHFPKITVKETIDFALKCKTPRVRIDKMTRK 264


>YQ5C_CAEEL (Q09466) Putative ABC transporter C16C10.12 in
           chromosome III
          Length = 610

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/132 (35%), Positives = 75/132 (56%), Gaps = 8/132 (6%)

Query: 261 PHSITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMD 320
           P ++T+++I       V+ +++   + +  LL  VSG  +PG + ALMG SGAGKTTLM+
Sbjct: 32  PITVTWENI------EVKTRKKLFSKKQKQLLNRVSGIAKPGEMVALMGASGAGKTTLMN 85

Query: 321 VLAGRKTGGY-IDGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLP 379
           VL  R   G   +G +KV+G  K  +  + ISG+ +  +I  P +TV E L+  A LR+ 
Sbjct: 86  VLMCRNMKGLEKNGTVKVNG-TKIGKEISLISGFAQQQEIFIPTLTVDEYLMIQARLRMK 144

Query: 380 SGVDSNTTKVSE 391
           +   +   +V E
Sbjct: 145 ANKHTRRERVDE 156


>PDRB_YEAST (P40550) ATP-dependent permease PDR11
          Length = 1410

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 44/127 (34%), Positives = 68/127 (52%), Gaps = 15/127 (11%)

Query: 252 KKGMVLPFEPHSITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVS 311
           K+ + +  + H I++ +I Y++         G ++    L+   SG    G LTALMG S
Sbjct: 738 KESVAMETQKHVISWKNINYTI---------GDKK----LINDASGYISSG-LTALMGES 783

Query: 312 GAGKTTLMDVLAGRKTGGYIDGDIKVSGYPKKQ-ETFARISGYCEHNDIHSPHVTVHESL 370
           GAGKTTL++VL+ R   G + G++ + G P    + F R  G+ +  D+H   +TV ESL
Sbjct: 784 GAGKTTLLNVLSQRTESGVVTGELLIDGQPLTNIDAFRRSIGFVQQQDVHLELLTVRESL 843

Query: 371 LYSAWLR 377
             S  LR
Sbjct: 844 EISCVLR 850


>AUS1_YEAST (Q08409) ATP-dependent permease AUS1
          Length = 1394

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/88 (43%), Positives = 53/88 (60%), Gaps = 2/88 (2%)

Query: 291 LLKGVSGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGDIKVSGYP-KKQETFAR 349
           L+   SG    G LTALMG SGAGKTTL++VL+ R   G + G+I + G+P   ++ F R
Sbjct: 765 LINNASGFISSG-LTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKR 823

Query: 350 ISGYCEHNDIHSPHVTVHESLLYSAWLR 377
             G+ +  D+H   ++V ESL  S  LR
Sbjct: 824 SIGFVQQQDLHLDLLSVKESLEISCLLR 851



 Score = 34.3 bits (77), Expect = 0.95
 Identities = 16/76 (21%), Positives = 34/76 (44%)

Query: 30  FFTLVTMMFNGMSEISMTIAKLPVYYKQRDLLFYPSWAYAIPSWILKIPVSLMEVSLWVF 89
           FF+++   F  ++++ +   + PV  KQ  L FY +W   + + +      L  V ++  
Sbjct: 425 FFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSI 484

Query: 90  LTYYVIGFDPNVGRMF 105
           + Y++        R F
Sbjct: 485 ILYFLAHLQYKAARFF 500


>ABG3_MOUSE (Q99P81) ATP-binding cassette, sub-family G, member 3
          Length = 650

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 44/132 (33%), Positives = 69/132 (51%), Gaps = 10/132 (7%)

Query: 262 HSITFDDIVYSVDMPVEMKEQGVREDRLVLLKGVSGAFRPGVLTALMGVSGAGKTTLMDV 321
           H+I++ + V S   P+  K   +       L  +SG  +PG L A+MG     ++ L+DV
Sbjct: 40  HNISYQETVQS-GFPLRKKAYVIER-----LSNISGIMKPG-LNAIMGPQDGSRSLLLDV 92

Query: 322 LAGRKTGGYIDGDIKVSGYPKKQETFARISGYCEHNDIHSPHVTVHESLLYSAWLRLPSG 381
           LA R+    + GDI ++G P +   F   SGY   ND+    VTV ++L +SA LRLP  
Sbjct: 93  LAARRDPRGLSGDILINGKP-RPANFKCTSGYVPQNDVVLGTVTVRDNLEFSAALRLPVT 151

Query: 382 V--DSNTTKVSE 391
           +  D    +++E
Sbjct: 152 ITRDEKRRRINE 163


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.331    0.145    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,508,332
Number of Sequences: 164201
Number of extensions: 3460377
Number of successful extensions: 16602
Number of sequences better than 10.0: 567
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 290
Number of HSP's that attempted gapping in prelim test: 14618
Number of HSP's gapped (non-prelim): 1382
length of query: 596
length of database: 59,974,054
effective HSP length: 116
effective length of query: 480
effective length of database: 40,926,738
effective search space: 19644834240
effective search space used: 19644834240
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.9 bits)
S2: 69 (31.2 bits)