BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC126012.1 + phase: 0
(220 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
6DCS_SOYBN (P26690) NAD(P)H dependent 6'-deoxychalcone synthase ... 363 e-100
ALDR_HORVU (P23901) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 144 2e-34
ALDR_BOVIN (P16116) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 141 1e-33
AKA1_RAT (P51635) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Al... 140 3e-33
AKA1_MOUSE (Q9JII6) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (... 139 5e-33
ALDR_PIG (P80276) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde ... 139 7e-33
AKA1_PIG (P50578) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Al... 139 7e-33
AKE1_MOUSE (Q9DCT1) Aldo-keto reductase family 1 member E1 (EC 1... 138 9e-33
ALDR_RAT (P07943) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde ... 137 3e-32
ALDR_HUMAN (P15121) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 135 6e-32
DDBX_BOVIN (P52898) Dihydrodiol dehydrogenase 3 (EC 1.-.-.-) (Pr... 135 7e-32
ALDR_RABIT (P15122) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 133 3e-31
ALDR_MOUSE (P45376) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 133 3e-31
AKA1_HUMAN (P14550) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (... 133 3e-31
AKC2_HUMAN (P52895) Aldo-keto reductase family 1 member C2 (EC 1... 132 5e-31
AKC1_HUMAN (Q04828) Aldo-keto reductase family 1 member C1 (EC 1... 132 6e-31
PGFS_BOVIN (P05980) Prostaglandin-F synthase 1 (EC 1.1.1.188) (P... 131 1e-30
PGF2_BOVIN (P52897) Prostaglandin-F synthase 2 (EC 1.1.1.188) (P... 131 1e-30
ALD2_MOUSE (P45377) Aldose reductase-related protein 2 (EC 1.1.1... 130 2e-30
ALD1_MOUSE (P21300) Aldose reductase-related protein 1 (EC 1.1.1... 129 5e-30
>6DCS_SOYBN (P26690) NAD(P)H dependent 6'-deoxychalcone synthase (EC
1.1.-.-)
Length = 315
Score = 363 bits (932), Expect = e-100
Identities = 175/208 (84%), Positives = 193/208 (92%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGVWESMEEGLKLGLTKAIG 72
S +TLQL+YLDLYLIHWPLSSQPGKF+FPI+V DLLPFDVKGVWESMEE KLGLTKAIG
Sbjct: 106 SLKTLQLEYLDLYLIHWPLSSQPGKFSFPIEVEDLLPFDVKGVWESMEECQKLGLTKAIG 165
Query: 73 VSNFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKGASRG 132
VSNFSVKKL+NLLSVATI P V+QVEMNLAWQQKKLREFC NGI++TAFSPLRKGASRG
Sbjct: 166 VSNFSVKKLQNLLSVATIRPVVDQVEMNLAWQQKKLREFCKENGIIVTAFSPLRKGASRG 225
Query: 133 PNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSLTKE 192
PNEVMEND+LKEIA+AHGKS+AQ+SLRWLYEQGVTFVPKSYDKERMNQNL IFDW+LT++
Sbjct: 226 PNEVMENDVLKEIAEAHGKSIAQVSLRWLYEQGVTFVPKSYDKERMNQNLHIFDWALTEQ 285
Query: 193 DHEKIDQIKQNRLIPGPTKPGINDLYDD 220
DH KI QI Q+RLI GPTKP + DL+DD
Sbjct: 286 DHHKISQISQSRLISGPTKPQLADLWDD 313
>ALDR_HORVU (P23901) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 320
Score = 144 bits (362), Expect = 2e-34
Identities = 73/192 (38%), Positives = 119/192 (61%), Gaps = 5/192 (2%)
Query: 15 RTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGVWESMEEGLKLGLTKAIGVS 74
+ LQLDY+DLY IHWP + G P + ++L FD++GVW+ ME +K GL K IGV
Sbjct: 108 KDLQLDYIDLYHIHWPFRLKDGAH-MPPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVC 166
Query: 75 NFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKGASRGPN 134
N++V KL LL A I PAV Q+EM+ W+ K+ E C +GI +TA+SPL G+S
Sbjct: 167 NYTVTKLNRLLRSAKIPPAVCQMEMHPGWKNDKIFEACKKHGIHVTAYSPL--GSSE--K 222
Query: 135 EVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSLTKEDH 194
+ + +++++A+ K+ Q+ ++W ++G + +PKS ER+ +N+ +F W + +ED
Sbjct: 223 NLAHDPVVEKVANKLNKTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDF 282
Query: 195 EKIDQIKQNRLI 206
+ + IK + +
Sbjct: 283 KVLCSIKDEKRV 294
>ALDR_BOVIN (P16116) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase) (20-alpha-hydroxysteroid dehydrogenase) (EC
1.1.1.149) (20-alpha-HSD)
Length = 315
Score = 141 bits (355), Expect = 1e-33
Identities = 79/186 (42%), Positives = 118/186 (62%), Gaps = 9/186 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDV-ADLLPF--DVKGVWESMEEGLKLGLTKAIGV 73
L+LDYLDLYLIHWP +PGK FP+D +++P D W +MEE + GL KAIGV
Sbjct: 99 LKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGV 158
Query: 74 SNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E +L+ + PAVNQ+E + Q+KL ++CN+ GIV+TA+SPL R
Sbjct: 159 SNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +K IAD + K+ AQ+ +R+ ++ + +PKS ER+ +N +FD+
Sbjct: 219 WAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDF 278
Query: 188 SLTKED 193
L KED
Sbjct: 279 ELDKED 284
>AKA1_RAT (P51635) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1) (3-DG-reducing enzyme)
Length = 324
Score = 140 bits (352), Expect = 3e-33
Identities = 75/194 (38%), Positives = 124/194 (63%), Gaps = 7/194 (3%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFD---VKGVWESMEEGLKLGLTKAIGV 73
LQL+YLDLYL+HWP + + G FP + + +D K W+++E + GL KA+G+
Sbjct: 101 LQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGL 160
Query: 74 SNFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKG--ASR 131
SNFS ++++++LSVA++ PAV QVE + Q +L C A G+ +TA+SPL A R
Sbjct: 161 SNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWR 220
Query: 132 GPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSL 189
P+E ++E ++ +A+ HG+S AQI LRW ++ V +PKS R+ QN+ +FD++
Sbjct: 221 HPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTF 280
Query: 190 TKEDHEKIDQIKQN 203
+ E+ +++D + +N
Sbjct: 281 SPEEMKQLDALNKN 294
>AKA1_MOUSE (Q9JII6) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 139 bits (350), Expect = 5e-33
Identities = 74/194 (38%), Positives = 126/194 (64%), Gaps = 7/194 (3%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFD---VKGVWESMEEGLKLGLTKAIGV 73
LQL+YLDLYL+HWP + + G FP + + +D K W+++E + GL KA+G+
Sbjct: 101 LQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGL 160
Query: 74 SNFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKG--ASR 131
SNF+ ++++++LSVA++ PAV QVE + Q +L C+A G+ +TA+SPL A R
Sbjct: 161 SNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWR 220
Query: 132 GPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSL 189
P+E ++E ++ +A+ HG+S AQI LRW ++ V +PKS + R+ QN+ +FD++
Sbjct: 221 HPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTF 280
Query: 190 TKEDHEKIDQIKQN 203
+ E+ +++D + +N
Sbjct: 281 SPEEMKQLDALNKN 294
>ALDR_PIG (P80276) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 139 bits (349), Expect = 7e-33
Identities = 80/198 (40%), Positives = 122/198 (61%), Gaps = 9/198 (4%)
Query: 15 RTLQLDYLDLYLIHWPLSSQPGKFTFPID-VADLLP--FDVKGVWESMEEGLKLGLTKAI 71
R L+LDYLDLYLIHWP +PGK FP+D +++P D WE+MEE + GL KAI
Sbjct: 97 RDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAI 156
Query: 72 GVSNFSVKKLENLLSVATI--LPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL---- 125
GVSNF+ ++E +L+ + PAVNQ+E++ Q+KL E+C + GIV+TA+SPL
Sbjct: 157 GVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPD 216
Query: 126 RKGASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIF 185
R A ++E+ +K IA + K+ AQ+ +R+ ++ + +PKS ER+ +N +F
Sbjct: 217 RPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVF 276
Query: 186 DWSLTKEDHEKIDQIKQN 203
D+ L+ ED + +N
Sbjct: 277 DFELSPEDMNTLLSYNRN 294
>AKA1_PIG (P50578) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 139 bits (349), Expect = 7e-33
Identities = 73/194 (37%), Positives = 124/194 (63%), Gaps = 7/194 (3%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDV---KGVWESMEEGLKLGLTKAIGV 73
LQL+YLDLYL+HWP + + G FP + + +D K W+++E + GL +A+G+
Sbjct: 101 LQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGL 160
Query: 74 SNFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKG--ASR 131
SNFS ++++++LSVA++ PAV QVE + Q +L C A G+ +TA+SPL A R
Sbjct: 161 SNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWR 220
Query: 132 GPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSL 189
PNE ++E +++ +A+ + +S AQI LRW ++ V +PKS R+ QN+ +FD++
Sbjct: 221 DPNEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTF 280
Query: 190 TKEDHEKIDQIKQN 203
+ E+ +++D + +N
Sbjct: 281 SPEEMKQLDALNKN 294
>AKE1_MOUSE (Q9DCT1) Aldo-keto reductase family 1 member E1 (EC
1.1.1.-)
Length = 301
Score = 138 bits (348), Expect = 9e-33
Identities = 79/206 (38%), Positives = 124/206 (59%), Gaps = 8/206 (3%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDV-ADLLPFDVK--GVWESMEEGLKLGLTKAIGV 73
L LDYLDLYLIHWP+ +PG+ P+D ++P WE+ME+ + GL K +GV
Sbjct: 91 LNLDYLDLYLIHWPMGFKPGEKDIPLDRNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGV 150
Query: 74 SNFSVKKLENLLSVA--TILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKGASR 131
SNF+ ++LE LL + P NQ+E + QKKL +FC+ + +TA+ PL G S
Sbjct: 151 SNFNHEQLERLLDKPGLRVRPITNQIECHPYLNQKKLIDFCHKRNVSVTAYRPL--GGSG 208
Query: 132 GPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSLTK 191
G +M++ ++++IA HGKS AQI +R+ ++ + +PKS R+ +N+ +FD+ LT+
Sbjct: 209 GGFHLMDDTVIRKIAKKHGKSPAQILIRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTE 268
Query: 192 EDHEKIDQIKQN-RLIPGPTKPGIND 216
+D E++ + +N RL PT D
Sbjct: 269 KDMEELLSLDKNLRLATFPTTENHQD 294
>ALDR_RAT (P07943) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 137 bits (344), Expect = 3e-32
Identities = 77/186 (41%), Positives = 117/186 (62%), Gaps = 9/186 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVA-DLLPFDVKGV--WESMEEGLKLGLTKAIGV 73
LQLDYLDLYLIHWP +PG FP+D + +++P D V W +ME+ + GL KAIGV
Sbjct: 99 LQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGV 158
Query: 74 SNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E +L+ + PAVNQ+E + Q+KL E+C+ GIV+TA+SPL R
Sbjct: 159 SNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +KEIA + K+ AQ+ +R+ ++ + +PKS R+ +N +FD+
Sbjct: 219 WAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDF 278
Query: 188 SLTKED 193
L+ ED
Sbjct: 279 ELSNED 284
>ALDR_HUMAN (P15121) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 135 bits (341), Expect = 6e-32
Identities = 75/186 (40%), Positives = 118/186 (63%), Gaps = 9/186 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVA-DLLPFD--VKGVWESMEEGLKLGLTKAIGV 73
L+LDYLDLYLIHWP +PGK FP+D + +++P D + W +MEE + GL KAIG+
Sbjct: 99 LKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGI 158
Query: 74 SNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E +L+ + PAVNQ+E + Q+KL ++C + GIV+TA+SPL R
Sbjct: 159 SNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +K IA H K+ AQ+ +R+ ++ + +PKS ER+ +N +FD+
Sbjct: 219 WAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDF 278
Query: 188 SLTKED 193
L+ +D
Sbjct: 279 ELSSQD 284
>DDBX_BOVIN (P52898) Dihydrodiol dehydrogenase 3 (EC 1.-.-.-)
(Prostaglandin F synthase)
Length = 323
Score = 135 bits (340), Expect = 7e-32
Identities = 80/203 (39%), Positives = 125/203 (61%), Gaps = 14/203 (6%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGV---WESMEEGLKLGLTK 69
S LQLDY+DLY+IH+P++ +PG+ FP D FD + WE++E+ GLTK
Sbjct: 102 SLNNLQLDYVDLYIIHFPVALKPGETLFPTDENGKPIFDSVDLCRTWEALEKCKDAGLTK 161
Query: 70 AIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRK 127
+IGVSNF+ K+LE +L+ + P NQVE + + Q KL +FC ++ IVL A+ L
Sbjct: 162 SIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYFNQSKLLDFCKSHDIVLVAYGAL-- 219
Query: 128 GASR-----GPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQ 180
G+ R PN ++E+ +L IA H ++ A ++LR+ ++GV + KSY+K+R+ +
Sbjct: 220 GSQRLKEWVNPNLPFLLEDPVLSAIAKKHRQTPALVALRYQIQRGVVVLAKSYNKKRIKE 279
Query: 181 NLCIFDWSLTKEDHEKIDQIKQN 203
N+ +FD+ LT ED + ID + N
Sbjct: 280 NIQVFDFELTPEDMKAIDGLNSN 302
>ALDR_RABIT (P15122) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 133 bits (335), Expect = 3e-31
Identities = 75/186 (40%), Positives = 116/186 (62%), Gaps = 9/186 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVA-DLLPFDVK--GVWESMEEGLKLGLTKAIGV 73
L+LDYLDLYLIHWP + G FP+D A +++P D WE+ME + GL K+IGV
Sbjct: 99 LKLDYLDLYLIHWPTGFKHGSEYFPLDAAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGV 158
Query: 74 SNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E +L+ + PAVNQ+E + Q+KL ++C++ GIV+TA+SPL R
Sbjct: 159 SNFNHLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +K IAD H K+ AQ+ +R+ ++ + +PKS R+ +N +FD+
Sbjct: 219 WAKPEDPSLLEDPRIKAIADKHKKTTAQVLIRFPMQRNLVVIPKSVTPARIAENFQVFDF 278
Query: 188 SLTKED 193
L+ ED
Sbjct: 279 ELSSED 284
>ALDR_MOUSE (P45376) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 133 bits (335), Expect = 3e-31
Identities = 75/186 (40%), Positives = 117/186 (62%), Gaps = 9/186 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVA-DLLPFDVKGV--WESMEEGLKLGLTKAIGV 73
LQLDYLDLYLIHWP +PG FP+D + +++P D V W +ME+ + GL K IGV
Sbjct: 99 LQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGV 158
Query: 74 SNFSVKKLENLLSVATI--LPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E +L+ + PAVNQ+E + Q+KL E+C++ GIV+TA+SPL R
Sbjct: 159 SNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +K IA + K+ AQ+ +R+ ++ + +PKS R+ +NL +FD+
Sbjct: 219 WAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDF 278
Query: 188 SLTKED 193
++ ED
Sbjct: 279 EVSSED 284
>AKA1_HUMAN (P14550) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 133 bits (335), Expect = 3e-31
Identities = 71/194 (36%), Positives = 124/194 (63%), Gaps = 7/194 (3%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFD---VKGVWESMEEGLKLGLTKAIGV 73
LQL+YLDLYL+HWP + + G FP + + +D K W+++E + GL +A+G+
Sbjct: 101 LQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGL 160
Query: 74 SNFSVKKLENLLSVATILPAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKG--ASR 131
SNF+ ++++++LSVA++ PAV QVE + Q +L C A G+ +TA+SPL A R
Sbjct: 161 SNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWR 220
Query: 132 GPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDWSL 189
P+E ++E ++ +A+ +G+S AQI LRW ++ V +PKS R+ QN+ +FD++
Sbjct: 221 DPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTF 280
Query: 190 TKEDHEKIDQIKQN 203
+ E+ ++++ + +N
Sbjct: 281 SPEEMKQLNALNKN 294
>AKC2_HUMAN (P52895) Aldo-keto reductase family 1 member C2 (EC
1.1.1.-) (Trans-1,2-dihydrobenzene-1,2-diol
dehydrogenase) (EC 1.3.1.20) (Chlordecone reductase
homolog HAKRD) (Dihydrodiol dehydrogenase/bile
acid-binding protein) (DD/BABP) (Dihydrodiol deh
Length = 323
Score = 132 bits (333), Expect = 5e-31
Identities = 78/201 (38%), Positives = 125/201 (61%), Gaps = 10/201 (4%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGV---WESMEEGLKLGLTK 69
S + LQLDY+DLYLIH+P+S +PG+ P D + FD + WE+ME+ GL K
Sbjct: 102 SLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAK 161
Query: 70 AIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL-- 125
+IGVSNF+ + LE +L+ + P NQVE + + Q+KL +FC + IVL A+S L
Sbjct: 162 SIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS 221
Query: 126 -RKGASRGPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNL 182
R+ PN ++E+ +L +A H ++ A I+LR+ ++GV + KSY+++R+ QN+
Sbjct: 222 HREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNV 281
Query: 183 CIFDWSLTKEDHEKIDQIKQN 203
+F++ LT E+ + ID + +N
Sbjct: 282 QVFEFQLTSEEMKAIDGLNRN 302
>AKC1_HUMAN (Q04828) Aldo-keto reductase family 1 member C1 (EC
1.1.1.-) (Trans-1,2-dihydrobenzene-1,2-diol
dehydrogenase) (EC 1.3.1.20) (High-affinity hepatic bile
acid-binding protein) (HBAB) (Chlordecone reductase
homolog HAKRC) (Dihydrodiol dehydrogen
Length = 323
Score = 132 bits (332), Expect = 6e-31
Identities = 77/201 (38%), Positives = 126/201 (62%), Gaps = 10/201 (4%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGV---WESMEEGLKLGLTK 69
S + LQLDY+DLYLIH+P+S +PG+ P D + FD + WE++E+ GL K
Sbjct: 102 SLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAK 161
Query: 70 AIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL-- 125
+IGVSNF+ ++LE +L+ + P NQVE + + Q+KL +FC + IVL A+S L
Sbjct: 162 SIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS 221
Query: 126 -RKGASRGPNE--VMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNL 182
R+ PN ++E+ +L +A H ++ A I+LR+ ++GV + KSY+++R+ QN+
Sbjct: 222 HREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNV 281
Query: 183 CIFDWSLTKEDHEKIDQIKQN 203
+F++ LT E+ + ID + +N
Sbjct: 282 QVFEFQLTSEEMKAIDGLNRN 302
>PGFS_BOVIN (P05980) Prostaglandin-F synthase 1 (EC 1.1.1.188) (PGF
synthase 1) (PGF 1) (Prostaglandin-D2 11 reductase 1)
(PGFSI)
Length = 323
Score = 131 bits (329), Expect = 1e-30
Identities = 77/201 (38%), Positives = 123/201 (60%), Gaps = 10/201 (4%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGV---WESMEEGLKLGLTK 69
S + LQLDY+DLY+IH P+S +PG P D + L FD + WE++E+ GLTK
Sbjct: 102 SLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDESGKLIFDSVDLCHTWEALEKCKDAGLTK 161
Query: 70 AIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL-- 125
+IGVSNF+ K+LE +L+ + P NQVE + Q KL EFC ++ IVL A++ L
Sbjct: 162 SIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHDIVLVAYAALGA 221
Query: 126 ---RKGASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNL 182
+ + ++E+ +L IA H ++ A ++LR+ ++GV + KS++K+R+ +N+
Sbjct: 222 QLLSEWVNSNNPVLLEDPVLCAIAKKHKQTPALVALRYQVQRGVVVLAKSFNKKRIKENM 281
Query: 183 CIFDWSLTKEDHEKIDQIKQN 203
+FD+ LT ED + ID + +N
Sbjct: 282 QVFDFELTPEDMKAIDGLNRN 302
>PGF2_BOVIN (P52897) Prostaglandin-F synthase 2 (EC 1.1.1.188) (PGF
synthase 2) (PGF 2) (Prostaglandin-D2 11 reductase 2)
(PGFSII)
Length = 323
Score = 131 bits (329), Expect = 1e-30
Identities = 77/201 (38%), Positives = 123/201 (60%), Gaps = 10/201 (4%)
Query: 13 SCRTLQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKGV---WESMEEGLKLGLTK 69
S + LQLDY+DLY+IH P+S +PG P D + L FD + WE++E+ GLTK
Sbjct: 102 SLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDESGKLIFDSVDLCHTWEALEKCKDAGLTK 161
Query: 70 AIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL-- 125
+IGVSNF+ K+LE +L+ + P NQVE + Q KL EFC ++ IVL A++ L
Sbjct: 162 SIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHDIVLVAYAALGA 221
Query: 126 ---RKGASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNL 182
+ + ++E+ +L IA H ++ A ++LR+ ++GV + KS++K+R+ +N+
Sbjct: 222 QLLSEWVNSNNPVLLEDPVLCAIAKKHKQTPALVALRYQVQRGVVVLAKSFNKKRIKENM 281
Query: 183 CIFDWSLTKEDHEKIDQIKQN 203
+FD+ LT ED + ID + +N
Sbjct: 282 QVFDFELTPEDMKAIDGLNRN 302
>ALD2_MOUSE (P45377) Aldose reductase-related protein 2 (EC
1.1.1.21) (AR) (Aldehyde reductase) (Fibroblast growth
factor regulated protein) (FR-1 protein)
Length = 315
Score = 130 bits (328), Expect = 2e-30
Identities = 77/196 (39%), Positives = 113/196 (57%), Gaps = 9/196 (4%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLL---PFDVKGVWESMEEGLKLGLTKAIGV 73
L+LDYLDLYLIHWP QPGK FP D + WE MEE + GL KA+GV
Sbjct: 99 LKLDYLDLYLIHWPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGV 158
Query: 74 SNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFSPL----RK 127
SNF+ ++E LL+ + P NQVE + Q+KL ++C++ GI +TA+SPL R
Sbjct: 159 SNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRP 218
Query: 128 GASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMNQNLCIFDW 187
A ++E+ +KEIA H K+ AQ+ +R+ ++ V +PKS R+ +N+ +FD+
Sbjct: 219 SAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDF 278
Query: 188 SLTKEDHEKIDQIKQN 203
L+ E+ I +N
Sbjct: 279 QLSDEEMATILSFNRN 294
>ALD1_MOUSE (P21300) Aldose reductase-related protein 1 (EC
1.1.1.21) (AR) (Aldehyde reductase) (VAS deferens
androgen-dependent protein) (MVDP) (Aldo-keto reductase
family 1 member B7)
Length = 315
Score = 129 bits (324), Expect = 5e-30
Identities = 80/204 (39%), Positives = 114/204 (55%), Gaps = 25/204 (12%)
Query: 17 LQLDYLDLYLIHWPLSSQPGKFTFPIDVADLLPFDVKG-----------VWESMEEGLKL 65
L+LDYLDLYL+HWP Q G LLP D KG WE+MEE +
Sbjct: 99 LKLDYLDLYLVHWPQGFQAGNA--------LLPKDNKGKVLLSKSTFLDAWEAMEELVDQ 150
Query: 66 GLTKAIGVSNFSVKKLENLLSVATIL--PAVNQVEMNLAWQQKKLREFCNANGIVLTAFS 123
GL KA+G+SNF+ ++E LL+ + P NQ+E + Q+KL ++C + GI +TA+S
Sbjct: 151 GLVKALGISNFNHFQIERLLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYS 210
Query: 124 PL----RKGASRGPNEVMENDMLKEIADAHGKSVAQISLRWLYEQGVTFVPKSYDKERMN 179
PL R A VME +KEIA H K+VAQ+ +R+ ++ V +PKS R+
Sbjct: 211 PLGSPDRPYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKSVTPSRIQ 270
Query: 180 QNLCIFDWSLTKEDHEKIDQIKQN 203
+NL +FD+ L++ED I +N
Sbjct: 271 ENLQVFDFQLSEEDMAAILSFNRN 294
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.319 0.138 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,183,124
Number of Sequences: 164201
Number of extensions: 1044135
Number of successful extensions: 2636
Number of sequences better than 10.0: 109
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2375
Number of HSP's gapped (non-prelim): 111
length of query: 220
length of database: 59,974,054
effective HSP length: 106
effective length of query: 114
effective length of database: 42,568,748
effective search space: 4852837272
effective search space used: 4852837272
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Medicago: description of AC126012.1