BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC125478.13 - phase: 0
(436 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
PDP2_HUMAN (Q9P2J9) [Pyruvate dehydrogenase [Lipoamide]]-phospha... 92 2e-18
P2CB_BOVIN (O62830) Protein phosphatase 2C beta isoform (EC 3.1.... 83 2e-15
PDP2_RAT (O88484) [Pyruvate dehydrogenase [Lipoamide]]-phosphata... 82 2e-15
FEM2_HUMAN (P49593) Ca(2+)/calmodulin-dependent protein kinase p... 81 6e-15
P2CB_MOUSE (P36993) Protein phosphatase 2C beta isoform (EC 3.1.... 79 2e-14
P2CB_RAT (P35815) Protein phosphatase 2C beta isoform (EC 3.1.3.... 79 3e-14
P2CB_HUMAN (O75688) Protein phosphatase 2C beta isoform (EC 3.1.... 78 4e-14
P2C2_SCHPO (Q09172) Protein phosphatase 2C homolog 2 (EC 3.1.3.1... 78 5e-14
P2C1_SCHPO (P40371) Protein phosphatase 2C homolog 1 (EC 3.1.3.1... 77 9e-14
P2CA_RAT (P20650) Protein phosphatase 2C alpha isoform (EC 3.1.3... 75 3e-13
P2CA_RABIT (P35814) Protein phosphatase 2C alpha isoform (EC 3.1... 75 3e-13
P2CA_HUMAN (P35813) Protein phosphatase 2C alpha isoform (EC 3.1... 75 3e-13
P2CA_MOUSE (P49443) Protein phosphatase 2C alpha isoform (EC 3.1... 75 3e-13
P2CA_BOVIN (O62829) Protein phosphatase 2C alpha isoform (EC 3.1... 75 4e-13
PDP1_BOVIN (P35816) [Pyruvate dehydrogenase [Lipoamide]]-phospha... 74 6e-13
P2C_PARTE (P49444) Protein phosphatase 2C (EC 3.1.3.16) (PP2C) 74 7e-13
P2C1_YEAST (P35182) Protein phosphatase 2C homolog 1 (EC 3.1.3.1... 74 7e-13
PDP1_RAT (O88483) [Pyruvate dehydrogenase [Lipoamide]]-phosphata... 73 1e-12
PDP1_HUMAN (Q9P0J1) [Pyruvate dehydrogenase [Lipoamide]]-phospha... 73 2e-12
P2C3_ARATH (P49599) Protein phosphatase 2C PPH1 (EC 3.1.3.16) (P... 72 2e-12
>PDP2_HUMAN (Q9P2J9) [Pyruvate dehydrogenase
[Lipoamide]]-phosphatase 2, mitochondrial precursor (EC
3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase,
catalytic subunit 2) (PDPC 2)
Length = 529
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/248 (32%), Positives = 117/248 (46%), Gaps = 50/248 (20%)
Query: 152 LHVANLGDSRAVIGTMVNNKI-QAEQLTRDHNCKDEAIRKELMSEHPD--DTTIVMYERE 208
LHVAN GD RA++G +N + LTRDHN ++A L EHP+ D TI+M +R
Sbjct: 279 LHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDR- 337
Query: 209 VWRVKGIITVSRSIGDTYLK---RPEFSLDESFPKFEEV-------PEPFIRGVLSAEPE 258
+ G++ R+ GD LK + S+ E E + P + L+AEPE
Sbjct: 338 ---LLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHYYTPPYLTAEPE 394
Query: 259 MRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNN------SRNGIAKR-----LVSTV 307
+ L DKFL+ ASDGLWD LSNE V +V + + +A+R L+ ++
Sbjct: 395 VTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSL 454
Query: 308 LAQAAAN------------------RNSTYNTMK----NANLGRGDGNRRYFHDDISVIV 345
L Q A+ N+ Y M+ A L + R + DDI+V V
Sbjct: 455 LLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLARMYRDDITVTV 514
Query: 346 VFLDKKSI 353
V+ + +SI
Sbjct: 515 VYFNSESI 522
Score = 30.4 bits (67), Expect = 9.3
Identities = 15/61 (24%), Positives = 31/61 (50%), Gaps = 1/61 (1%)
Query: 43 QFSSAFVQANEAMEDHSQV-EVASRKALFLGVYDGHAGFEASVFITQHLFDHLLRAVRAN 101
+F S + AN +ED V L G++DGH G + +++ LF ++ ++ ++
Sbjct: 108 RFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSH 167
Query: 102 E 102
+
Sbjct: 168 Q 168
>P2CB_BOVIN (O62830) Protein phosphatase 2C beta isoform (EC
3.1.3.16) (PP2C-beta)
Length = 387
Score = 82.8 bits (203), Expect = 2e-15
Identities = 67/232 (28%), Positives = 106/232 (44%), Gaps = 34/232 (14%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLR----AVRANENKITEPTLRDAVSATEAGFL--- 122
F VYDGHAG + + + HL +H+ EP++ + + GFL
Sbjct: 55 FFAVYDGHAGSRVANYCSTHLLEHITNNEDFRAAGKSGSALEPSVENVKNGIRTGFLKID 114
Query: 123 EYVEKNYRQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHN 182
EY+ +N + + GS + +I K ++ N GDSRAV+ Q T+DH
Sbjct: 115 EYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVL----YRSGQVCFSTQDHK 170
Query: 183 CKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFE 242
+ ++ + + VM +R V G + VSR++GD K +D P +
Sbjct: 171 PCNPREKERIQNAGGS----VMIQR----VNGSLAVSRALGDYDYK----CVDGKGPTEQ 218
Query: 243 EV-PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
V PEP + +L AE D+F+I A DG+WD +SNE+ E V++
Sbjct: 219 LVSPEPEVYEILRAE----------EDEFIILACDGIWDVMSNEELCEFVKS 260
>PDP2_RAT (O88484) [Pyruvate dehydrogenase [Lipoamide]]-phosphatase
2, mitochondrial precursor (EC 3.1.3.43) (PDP 2)
(Pyruvate dehydrogenase phosphatase, catalytic subunit
2) (PDPC 2)
Length = 530
Score = 82.4 bits (202), Expect = 2e-15
Identities = 75/248 (30%), Positives = 113/248 (45%), Gaps = 50/248 (20%)
Query: 152 LHVANLGDSRAVIGTMVNNKI-QAEQLTRDHNCKDEAIRKELMSEHPD--DTTIVMYERE 208
LH+AN GD RA++G +N LT DHN +EA L EHP+ D T+++ +R
Sbjct: 280 LHIANAGDCRAILGVQGDNGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDR- 338
Query: 209 VWRVKGIITVSRSIGDTYLKRP--------EFSLDESFPKFEEVPEPFIRG--VLSAEPE 258
+ G++ R+ GD LK E D + P L+A+PE
Sbjct: 339 ---LLGVLLPCRAFGDVQLKWSKELQRNVLERGFDTEALNIYQFTPPHYHTPPYLTAKPE 395
Query: 259 MRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNN-SRNGIAKRL----------VSTV 307
+ L DKFL+ ASDGLWD L NE V +V + S+ G K + ++
Sbjct: 396 VTYHRLRPQDKFLVLASDGLWDMLDNEDVVRLVVGHLSKVGHQKPALDQRPANLGHMQSL 455
Query: 308 LAQA------AANRNSTYNTMKNA----NLGRGDGNR------------RYFHDDISVIV 345
L Q AA++N+ + +++A G + R R + DDI+V+V
Sbjct: 456 LLQRKASGLHAADQNAATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARMYRDDITVMV 515
Query: 346 VFLDKKSI 353
VF + +SI
Sbjct: 516 VFFNSESI 523
Score = 30.4 bits (67), Expect = 9.3
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 3/54 (5%)
Query: 43 QFSSAFVQANEAMEDHSQVE--VASRKALFLGVYDGHAGFEASVFITQHLFDHL 94
+F S + AN +ED V V +R +F G++DGH G + +++ LF ++
Sbjct: 109 RFESNQLAANSPVEDRQGVASCVQTRGTVF-GIFDGHGGHACAQAVSERLFYYM 161
>FEM2_HUMAN (P49593) Ca(2+)/calmodulin-dependent protein kinase
phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase)
(CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein
phosphatase 1F)
Length = 454
Score = 80.9 bits (198), Expect = 6e-15
Identities = 79/282 (28%), Positives = 124/282 (43%), Gaps = 64/282 (22%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
+ V+DGH G +A+ + H+ + R + E LR+A T+ FL K
Sbjct: 193 YFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDP--EGALREAFRRTDQMFLR---KAK 247
Query: 130 RQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCK--DEA 187
R++ G G C L I TLHVA LGDS+ ++ + Q +L H + DE
Sbjct: 248 RERLQSGTTGVCAL---IAGATLHVAWLGDSQVILV----QQGQVVKLMEPHRPERQDEK 300
Query: 188 IRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEVPEP 247
R E + + + WRV G + VSR+IGD + K P
Sbjct: 301 ARIEALGGF-------VSHMDCWRVNGTLAVSRAIGDVFQK------------------P 335
Query: 248 FIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNN-SRNGIAKRLVST 306
++ G E + SR LT ++ +L+ A DG +D + +++ V +VQ++ +R + V+
Sbjct: 336 YVSG----EADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAE 391
Query: 307 VLAQAAANRNSTYNTMKNANLGRGDGNRRYFHDDISVIVVFL 348
L AA R S HD+I+V+VVFL
Sbjct: 392 ELVAAARERGS--------------------HDNITVMVVFL 413
>P2CB_MOUSE (P36993) Protein phosphatase 2C beta isoform (EC
3.1.3.16) (PP2C-beta) (IA) (Protein phosphatase 1B)
Length = 390
Score = 79.3 bits (194), Expect = 2e-14
Identities = 65/232 (28%), Positives = 107/232 (46%), Gaps = 34/232 (14%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHL-----LRAVRANENKITEPTLRDAVSATEAGFL-- 122
F VYDGHAG + + + HL +H+ RA + + + EP++ + GFL
Sbjct: 55 FFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKSGSAL-EPSVESVKTGIRTGFLKI 113
Query: 123 -EYVEKNYRQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDH 181
EY+ +N + + GS + ++ ++ N GDSRAV+ N ++ T+DH
Sbjct: 114 DEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCR--NGQVCFS--TQDH 169
Query: 182 NCKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKF 241
+ KE + I RV G + VSR++GD K +D P
Sbjct: 170 K-PCNPVEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDYDYK----CVDGKGPTE 217
Query: 242 EEVPEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
+ ++S EPE+ E D+F++ A DG+WD +SNE+ E V++
Sbjct: 218 Q---------LVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEFVKS 260
>P2CB_RAT (P35815) Protein phosphatase 2C beta isoform (EC 3.1.3.16)
(PP2C-beta) (IA) (Protein phosphatase 1B)
Length = 390
Score = 78.6 bits (192), Expect = 3e-14
Identities = 70/235 (29%), Positives = 111/235 (46%), Gaps = 36/235 (15%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLL--RAVRANENK--ITEPTLRDAVSATEAGFL--- 122
F VYDGHAG + + + HL +H+ RA + EP++ + + GFL
Sbjct: 55 FFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENVKTGIRTGFLKID 114
Query: 123 EYVEKNYRQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHN 182
EY+ +N + + GS + +I ++ N GDSRAV+ N ++ T+DH
Sbjct: 115 EYMRNFSDLRNGMDRSGSTAVGVMISPTHIYFINCGDSRAVLCR--NGQVCFS--TQDHK 170
Query: 183 CKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFE 242
+ ++ + + VM +R V G + VSR++GD K +D P +
Sbjct: 171 PCNPMEKERIQNAGGS----VMIQR----VNGSLAVSRALGDYDYK----CVDGKGPTEQ 218
Query: 243 EV-PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNNSR 296
V PEP + +L AE D+F++ A DG+WD +SNE+ E V NSR
Sbjct: 219 LVSPEPEVYEILRAE----------EDEFVVLACDGIWDVMSNEELCEFV--NSR 261
>P2CB_HUMAN (O75688) Protein phosphatase 2C beta isoform (EC
3.1.3.16) (PP2C-beta)
Length = 479
Score = 78.2 bits (191), Expect = 4e-14
Identities = 66/232 (28%), Positives = 107/232 (45%), Gaps = 34/232 (14%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLR----AVRANENKITEPTLRDAVSATEAGFL--- 122
F VYDGHAG + + + HL +H+ E ++ + + GFL
Sbjct: 55 FFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKID 114
Query: 123 EYVEKNYRQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHN 182
EY+ +N + + GS + +I K ++ N GDSRAV+ N ++ T+DH
Sbjct: 115 EYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYR--NGQVCFS--TQDHK 170
Query: 183 CKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFE 242
+ ++ + + VM +R V G + VSR++GD K +D P +
Sbjct: 171 PCNPREKERIQNAGGS----VMIQR----VNGSLAVSRALGDYDYK----CVDGKGPTEQ 218
Query: 243 EV-PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
V PEP + +L AE D+F+I A DG+WD +SNE+ E V++
Sbjct: 219 LVSPEPEVYEILRAE----------EDEFIILACDGIWDVMSNEELCEYVKS 260
>P2C2_SCHPO (Q09172) Protein phosphatase 2C homolog 2 (EC 3.1.3.16)
(PP2C-2)
Length = 370
Score = 77.8 bits (190), Expect = 5e-14
Identities = 72/249 (28%), Positives = 114/249 (44%), Gaps = 41/249 (16%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F GV+DGH G + + QHL D + + E A ++GFL +
Sbjct: 58 FFGVFDGHGGDRVAKYCRQHLPDIIKSQPSFWKGNYDE--------ALKSGFLA-ADNAL 108
Query: 130 RQKNNLGKVGSCCLAG---IIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKDE 186
Q ++ + S C A I+ + ++ AN GDSR V+G K AE L+ DH ++
Sbjct: 109 MQDRDMQEDPSGCTATTALIVDHQVIYCANAGDSRTVLG----RKGTAEPLSFDHKPNND 164
Query: 187 AIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEVPE 246
+ + T + RV G + +SR+IGD E+ D S P PE
Sbjct: 165 VEKARI--------TAAGGFIDFGRVNGSLALSRAIGDF-----EYKKDSSLP-----PE 206
Query: 247 PFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNNSRNGIAKRLVST 306
+ +++A P++ ++ +D+FLI A DG+WD S++Q VE V R GI R
Sbjct: 207 ---KQIVTAFPDVVIHNIDPDDEFLILACDGIWDCKSSQQVVEFV----RRGIVARQSLE 259
Query: 307 VLAQAAANR 315
V+ + +R
Sbjct: 260 VICENLMDR 268
>P2C1_SCHPO (P40371) Protein phosphatase 2C homolog 1 (EC 3.1.3.16)
(PP2C-1)
Length = 347
Score = 77.0 bits (188), Expect = 9e-14
Identities = 76/273 (27%), Positives = 122/273 (43%), Gaps = 56/273 (20%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F+ VYDGHAG +AS + ++L LL VR +++ + + F+E K
Sbjct: 104 FVAVYDGHAGIQASDYCQKNLHKVLLEKVRNEPDRLVTDLMDET-------FVEVNSKIA 156
Query: 130 RQKNNLGKVGSCCLAGIIWK-------KTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHN 182
+ +N + C A ++ + L+ AN GD+R V+ +A +L+ DH
Sbjct: 157 KATHN--DICGCTAAVAFFRYEKNRTRRVLYTANAGDARIVLC----RDGKAIRLSYDHK 210
Query: 183 CKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFE 242
D S +M + R+ G++ V+R++GDTYLK
Sbjct: 211 GSDAN-----ESRRVTQLGGLMVQN---RINGVLAVTRALGDTYLKE------------- 249
Query: 243 EVPEPFIRGVLSAEP-EMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNNSRNGIAK 301
++SA P +R +D+F I A DGLWD +S+++AV+ V RN ++
Sbjct: 250 ---------LVSAHPFTTETRIWNGHDEFFIIACDGLWDVVSDQEAVDFV----RNFVSP 296
Query: 302 RLVSTVLAQAAANRNSTYN-TMKNANLGRGDGN 333
R + L + A R ST N T NL R G+
Sbjct: 297 REAAVRLVEFALKRLSTDNITCIVVNLTRNPGD 329
>P2CA_RAT (P20650) Protein phosphatase 2C alpha isoform (EC
3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
Length = 382
Score = 75.5 bits (184), Expect = 3e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 32/229 (13%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F VYDGHAG + + + +HL DH+ + + P++ + + GFLE ++++
Sbjct: 55 FFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFKGSAGAPSVENVKNGIRTGFLE-IDEHM 112
Query: 130 R----QKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKD 185
R +K+ + GS + +I + + N GDSR G + N+ + T+DH
Sbjct: 113 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSR---GLLCRNR-KVHFFTQDHK-PS 167
Query: 186 EAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEV- 244
+ KE + I RV G + VSR++GD K + P + V
Sbjct: 168 NPLEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDFDYK----CVHGKGPTEQLVS 216
Query: 245 PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
PEP + + +E E+D+F+I A DG+WD + NE+ + V++
Sbjct: 217 PEPEVHDIERSE---------EDDQFIILACDGIWDVMGNEELCDFVRS 256
>P2CA_RABIT (P35814) Protein phosphatase 2C alpha isoform (EC
3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
Length = 382
Score = 75.5 bits (184), Expect = 3e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 32/229 (13%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F VYDGHAG + + + +HL DH+ + + P++ + + GFLE ++++
Sbjct: 55 FFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFKGSAGAPSVENVKNGIRTGFLE-IDEHM 112
Query: 130 R----QKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKD 185
R +K+ + GS + +I + + N GDSR G + N+ + T+DH
Sbjct: 113 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSR---GLLCRNR-KVHFFTQDHK-PS 167
Query: 186 EAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEV- 244
+ KE + I RV G + VSR++GD K + P + V
Sbjct: 168 NPLEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDFDYK----CVHGKGPTEQLVS 216
Query: 245 PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
PEP + + +E E+D+F+I A DG+WD + NE+ + V++
Sbjct: 217 PEPEVHDIERSE---------EDDQFIILACDGIWDVMGNEELCDFVRS 256
>P2CA_HUMAN (P35813) Protein phosphatase 2C alpha isoform (EC
3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
Length = 382
Score = 75.5 bits (184), Expect = 3e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 32/229 (13%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F VYDGHAG + + + +HL DH+ + + P++ + + GFLE ++++
Sbjct: 55 FFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFKGSAGAPSVENVKNGIRTGFLE-IDEHM 112
Query: 130 R----QKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKD 185
R +K+ + GS + +I + + N GDSR G + N+ + T+DH
Sbjct: 113 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSR---GLLCRNR-KVHFFTQDHK-PS 167
Query: 186 EAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEV- 244
+ KE + I RV G + VSR++GD K + P + V
Sbjct: 168 NPLEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDFDYK----CVHGKGPTEQLVS 216
Query: 245 PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
PEP + + +E E+D+F+I A DG+WD + NE+ + V++
Sbjct: 217 PEPEVHDIERSE---------EDDQFIILACDGIWDVMGNEELCDFVRS 256
>P2CA_MOUSE (P49443) Protein phosphatase 2C alpha isoform (EC
3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
Length = 382
Score = 75.1 bits (183), Expect = 3e-13
Identities = 62/229 (27%), Positives = 106/229 (46%), Gaps = 32/229 (13%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F VYDGHAG + + + +HL DH+ + P++ + + GFLE ++++
Sbjct: 55 FFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFRGSAGAPSVENVKNGIRTGFLE-IDEHM 112
Query: 130 R----QKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKD 185
R +K+ + GS + +I + + N GDSR G + N+ + T+DH
Sbjct: 113 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSR---GLLCRNR-KVHFFTQDHK-PS 167
Query: 186 EAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEV- 244
+ KE + I RV G + VSR++GD K + P + V
Sbjct: 168 NPLEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDFDYK----CVHGKGPTEQLVS 216
Query: 245 PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
PEP + + +E E+D+F+I A DG+WD + NE+ + V++
Sbjct: 217 PEPEVHDIERSE---------EDDQFIILACDGIWDVMGNEELCDFVRS 256
>P2CA_BOVIN (O62829) Protein phosphatase 2C alpha isoform (EC
3.1.3.16) (PP2C-alpha)
Length = 382
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 32/229 (13%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
F VYDGHAG + + + +HL DH+ + + P++ + + GFLE ++++
Sbjct: 55 FFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFKGSAGAPSVENVKNGIRTGFLE-IDEHM 112
Query: 130 R----QKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKD 185
R +K+ + GS + +I + + N GDSR ++ N K+ T+DH
Sbjct: 113 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCR--NRKVYF--FTQDHK-PS 167
Query: 186 EAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEV- 244
+ KE + I RV G + VSR++GD K + P + V
Sbjct: 168 NPLEKERIQNAGGSVMIQ-------RVNGSLAVSRALGDFDYK----CVHGKGPTEQLVS 216
Query: 245 PEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
PEP + + +E E+D+F+I A DG+WD + NE+ + V++
Sbjct: 217 PEPEVHDIERSE---------EDDQFIILACDGIWDVMGNEELCDFVRS 256
>PDP1_BOVIN (P35816) [Pyruvate dehydrogenase
[Lipoamide]]-phosphatase 1, mitochondrial precursor (EC
3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase,
catalytic subunit 1) (PDPC 1)
Length = 538
Score = 74.3 bits (181), Expect = 6e-13
Identities = 50/153 (32%), Positives = 76/153 (48%), Gaps = 16/153 (10%)
Query: 152 LHVANLGDSRAVIGTMVNN-KIQAEQLTRDHNCKDEAIRKELMSEHPDDTTIVMYEREVW 210
LHVAN GDSRA++G + A L+ DHN ++E + L EHP + + +++
Sbjct: 284 LHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNEREVERLKLEHPKNEAKSVVKQD-- 341
Query: 211 RVKGIITVSRSIGDTYLK------------RPEFSLDESFPKFEEVPEPFIRGVLSAEPE 258
R+ G++ R+ GD K P+ D + KF P + L+AEPE
Sbjct: 342 RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIP-PNYYTPPYLTAEPE 400
Query: 259 MRSRDLTENDKFLIFASDGLWDFLSNEQAVEIV 291
+ L DKFL+ A+DGLW+ + + V IV
Sbjct: 401 VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433
Score = 37.0 bits (84), Expect = 0.100
Identities = 24/78 (30%), Positives = 40/78 (50%), Gaps = 7/78 (8%)
Query: 44 FSSAFVQANEAMEDH-SQVEVASRKALFLGVYDGHAGFEASVFITQHLFDHLLRAVRANE 102
F S + AN +ED S + + LGV+DGHAG S +++ LF ++ ++ +E
Sbjct: 112 FDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHE 171
Query: 103 NKITEPTLRDAVSATEAG 120
TL + +A E+G
Sbjct: 172 ------TLLEIENAVESG 183
>P2C_PARTE (P49444) Protein phosphatase 2C (EC 3.1.3.16) (PP2C)
Length = 300
Score = 73.9 bits (180), Expect = 7e-13
Identities = 75/282 (26%), Positives = 119/282 (41%), Gaps = 39/282 (13%)
Query: 42 GQFSSAFVQANE------AMED-HSQVEVASRKALFLGVYDGHAGFEASVFITQHLFDHL 94
GQ S A+E MED H + GV+DGH G E + F+ +H D L
Sbjct: 17 GQGKSVIFAASEMQGWRNTMEDAHIHRHDIIQDVSVFGVFDGHGGREVAQFVEKHFVDEL 76
Query: 95 LRAVRANENKITEPTLRDAVSATEAGFLEYVEKNYRQ----KNNLGKVGSCCLAGIIWKK 150
L+ E K E + E +K Q + G +I+K
Sbjct: 77 LKNKNFKEQKFEEALKETFLKMDELLLTPEGQKELNQYKATDTDESYAGCTANVALIYKN 136
Query: 151 TLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNCKDEAIRKELMSEHPDDTTIVMYEREVW 210
TL+VAN GDSR+V+ NN + + +E R E D
Sbjct: 137 TLYVANAGDSRSVL--CRNNTNHDMSVDHKPDNPEEKSRIERAGGFVSD----------G 184
Query: 211 RVKGIITVSRSIGDTYLKRPEFSLDESFPKFEEVPEPFIRGVLSAEPEMRSRDLTENDKF 270
RV G + +SR++GD KR D E+ ++ A P+++ +LT DKF
Sbjct: 185 RVNGNLNLSRALGDLEYKR-----DNKLRSNEQ--------LIIALPDVKKTELTPQDKF 231
Query: 271 LIFASDGLWDFLSNEQAVEIVQNNSRNGIAKRLVSTVLAQAA 312
++ DG+++ L++++ ++ Q NS G A ++ +L +AA
Sbjct: 232 ILMGCDGVFETLNHQELLK--QVNSTIGQA-QVTEELLKKAA 270
>P2C1_YEAST (P35182) Protein phosphatase 2C homolog 1 (EC 3.1.3.16)
(PP2C-1)
Length = 281
Score = 73.9 bits (180), Expect = 7e-13
Identities = 68/256 (26%), Positives = 108/256 (41%), Gaps = 59/256 (23%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAGFLEYVEKNY 129
+ V+DGHAG +AS + +HL + + + A+E + L D+ A + E N
Sbjct: 53 YFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDE------EINT 106
Query: 130 RQKNNLGKVGSCCLAGIIWK----------------KTLHVANLGDSRAVIGTMVNNKIQ 173
+ N G + C+ + W+ + L+ AN+GDSR V+ N+
Sbjct: 107 KLVGNSGCTAAVCV--LRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSI-- 162
Query: 174 AEQLTRDHNCKDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFS 233
+LT DH D M ++M R V G++ V+RS+GD
Sbjct: 163 --RLTYDHKASDTLE----MQRVEQAGGLIMKSR----VNGMLAVTRSLGDK-------- 204
Query: 234 LDESFPKFEEVPEPFIRGVLSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQN 293
F ++ P S ++T DKFLI A DGLWD + ++ A E++++
Sbjct: 205 --------------FFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKD 250
Query: 294 -NSRNGIAKRLVSTVL 308
N AK LV L
Sbjct: 251 ITEPNEAAKVLVRYAL 266
>PDP1_RAT (O88483) [Pyruvate dehydrogenase [Lipoamide]]-phosphatase
1, mitochondrial precursor (EC 3.1.3.43) (PDP 1)
(Pyruvate dehydrogenase phosphatase, catalytic subunit
1) (PDPC 1)
Length = 538
Score = 73.2 bits (178), Expect = 1e-12
Identities = 50/153 (32%), Positives = 75/153 (48%), Gaps = 16/153 (10%)
Query: 152 LHVANLGDSRAVIGTMVNN-KIQAEQLTRDHNCKDEAIRKELMSEHPDDTTIVMYEREVW 210
LHVAN GDSRA++G + A L+ DHN ++E + L EHP + + +++
Sbjct: 284 LHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELQRLKLEHPKNEAKSVVKQD-- 341
Query: 211 RVKGIITVSRSIGDTYLK------------RPEFSLDESFPKFEEVPEPFIRGVLSAEPE 258
R+ G++ R+ GD K P+ D + KF P L+AEPE
Sbjct: 342 RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIP-PNYHTPPYLTAEPE 400
Query: 259 MRSRDLTENDKFLIFASDGLWDFLSNEQAVEIV 291
+ L DKFL+ A+DGLW+ + + V IV
Sbjct: 401 VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433
Score = 37.0 bits (84), Expect = 0.100
Identities = 24/78 (30%), Positives = 40/78 (50%), Gaps = 7/78 (8%)
Query: 44 FSSAFVQANEAMEDH-SQVEVASRKALFLGVYDGHAGFEASVFITQHLFDHLLRAVRANE 102
F S + AN +ED S + + LGV+DGHAG S +++ LF ++ ++ +E
Sbjct: 112 FDSNRLPANAPIEDRRSATTCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHE 171
Query: 103 NKITEPTLRDAVSATEAG 120
TL + +A E+G
Sbjct: 172 ------TLLEIENAVESG 183
>PDP1_HUMAN (Q9P0J1) [Pyruvate dehydrogenase
[Lipoamide]]-phosphatase 1, mitochondrial precursor (EC
3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase,
catalytic subunit 1) (PDPC 1)
Length = 538
Score = 72.8 bits (177), Expect = 2e-12
Identities = 50/153 (32%), Positives = 74/153 (47%), Gaps = 16/153 (10%)
Query: 152 LHVANLGDSRAVIGTMVNN-KIQAEQLTRDHNCKDEAIRKELMSEHPDDTTIVMYEREVW 210
LHVAN GDSRA++G + A L+ DHN ++E + L EHP + +++
Sbjct: 284 LHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQD-- 341
Query: 211 RVKGIITVSRSIGDTYLK------------RPEFSLDESFPKFEEVPEPFIRGVLSAEPE 258
R+ G++ R+ GD K P+ D + KF P L+AEPE
Sbjct: 342 RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIP-PNYHTPPYLTAEPE 400
Query: 259 MRSRDLTENDKFLIFASDGLWDFLSNEQAVEIV 291
+ L DKFL+ A+DGLW+ + + V IV
Sbjct: 401 VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433
Score = 35.0 bits (79), Expect = 0.38
Identities = 30/113 (26%), Positives = 51/113 (44%), Gaps = 15/113 (13%)
Query: 9 VNLCRKRKNDNINMALFDQDPHASSIDLKRHCYGQFSSAFVQANEAMEDH-SQVEVASRK 67
VN K + + FD S+DL ++ + AN +ED S +
Sbjct: 85 VNSILKANEYSFKVPEFDGKMSVLSLDL--------TAIKLPANAPIEDRRSAATCLQTR 136
Query: 68 ALFLGVYDGHAGFEASVFITQHLFDHLLRAVRANENKITEPTLRDAVSATEAG 120
+ LGV+DGHAG S +++ LF ++ ++ +E TL + +A E+G
Sbjct: 137 GMLLGVFDGHAGCAWSQAVSERLFYYIAGSLVPHE------TLLEIENAVESG 183
>P2C3_ARATH (P49599) Protein phosphatase 2C PPH1 (EC 3.1.3.16)
(PP2C)
Length = 388
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/275 (26%), Positives = 124/275 (44%), Gaps = 27/275 (9%)
Query: 70 FLGVYDGHAGFEASVFITQHLFDHLLRAVRAN------ENKITEPTLRDAVSATEAGFLE 123
+ V+DGHAG + F+ + L+ + A++A + + L A + + L+
Sbjct: 88 YAAVFDGHAGSSSVKFLREELYKECVGALQAGSLLNGGDFAAIKEALIKAFESVDRNLLK 147
Query: 124 YVEKNYRQKNNLGKVGSCCLAGIIWKKTLHVANLGDSRAVIGTMVNNKIQAEQLTRDHNC 183
++E N +++ + GS II +A++GDS AV+ + Q E+LT H
Sbjct: 148 WLEANGDEED---ESGSTATVMIIRNDVSFIAHIGDSCAVL----SRSGQIEELTDYHRP 200
Query: 184 --KDEAIRKELMSEHPDDTTIVMYEREVWRVKGIITVSRSIGDTYLKRPEFSLDESFPKF 241
A +E+ IV R+ G I VSR+ GD K + + +
Sbjct: 201 YGSSRAAIQEVKRVKEAGGWIVN-----GRICGDIAVSRAFGDIRFKTKKNDMLKKGVDE 255
Query: 242 EEVPEPFIRGV------LSAEPEMRSRDLTENDKFLIFASDGLWDFLSNEQAVEIVQNNS 295
E F+ + + A P++ LT + +F+I ASDGLWD++ + V V++
Sbjct: 256 GRWSEKFVSRIEFKGDMVVATPDIFQVPLTSDVEFIILASDGLWDYMKSSDVVSYVRDQL 315
Query: 296 RNGIAKRLVSTVLAQAAANRNSTYN-TMKNANLGR 329
R +L LAQ A +R S N ++ A+LGR
Sbjct: 316 RKHGNVQLACESLAQVALDRRSQDNISIIIADLGR 350
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.131 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,390,904
Number of Sequences: 164201
Number of extensions: 1867224
Number of successful extensions: 5234
Number of sequences better than 10.0: 55
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 5079
Number of HSP's gapped (non-prelim): 77
length of query: 436
length of database: 59,974,054
effective HSP length: 113
effective length of query: 323
effective length of database: 41,419,341
effective search space: 13378447143
effective search space used: 13378447143
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Medicago: description of AC125478.13