BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC125477.10 - phase: 0 /pseudo
(355 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
VIL4_ARATH (O65570) Villin 4 570 e-162
VIL2_ARATH (O81644) Villin 2 452 e-127
VIL3_ARATH (O81645) Villin 3 435 e-121
VIL1_ARATH (O81643) Villin 1 330 3e-90
GELS_DROME (Q07171) Gelsolin precursor 201 3e-51
GELS_CHICK (O93510) Gelsolin precursor (Actin-depolymerizing fac... 191 2e-48
GELS_PIG (P20305) Gelsolin precursor, plasma (Actin-depolymerizi... 187 3e-47
GELS_HORSE (Q28372) Gelsolin (Actin-depolymerizing factor) (ADF)... 186 6e-47
GELS_HUMAN (P06396) Gelsolin precursor, plasma (Actin-depolymeri... 182 1e-45
GELS_MOUSE (P13020) Gelsolin precursor, plasma (Actin-depolymeri... 180 4e-45
GELS_HOMAM (Q27319) Gelsolin, cytoplasmic (Actin-depolymerizing ... 173 7e-43
VIL1_MOUSE (Q62468) Villin 1 171 3e-42
SEVE_DICDI (P10733) Severin 170 6e-42
ADSV_HUMAN (Q9Y6U3) Adseverin (Scinderin) 166 6e-41
ADVL_HUMAN (O75366) Advillin (p92) 166 8e-41
ADSV_MOUSE (Q60604) Adseverin (Scinderin) (Gelsolin-like protein) 164 4e-40
VIL1_HUMAN (P09327) Villin 1 162 9e-40
ADSV_BOVIN (Q28046) Adseverin (Scinderin) (SC) 162 1e-39
ADVL_MOUSE (O88398) Advillin (p92) (Actin-binding protein DOC6) 160 3e-39
FLIH_HUMAN (Q13045) Flightless-I protein homolog 140 4e-33
>VIL4_ARATH (O65570) Villin 4
Length = 974
Score = 570 bits (1468), Expect = e-162
Identities = 270/344 (78%), Positives = 311/344 (89%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
TTA K+GALRHDIHYWLGKDTSQDEAG AA+KTVELDA LGGRAVQYREVQGHET+KFLS
Sbjct: 53 TTALKTGALRHDIHYWLGKDTSQDEAGTAAVKTVELDAALGGRAVQYREVQGHETEKFLS 112
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
YFKPCIIPQEGG ASGFKHV AEEH TRLFVC+GKHVV+VKEVPFARSSLNHDDI+ILDT
Sbjct: 113 YFKPCIIPQEGGVASGFKHVVAEEHITRLFVCRGKHVVHVKEVPFARSSLNHDDIYILDT 172
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
+SKIFQFNGSNSSIQERAKALEVVQYIKDTYHDG CEVA++EDG+LMAD++SGEFWG FG
Sbjct: 173 KSKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGTCEVATVEDGKLMADADSGEFWGFFG 232
Query: 181 GFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVF 240
GFAPLPRKT +D+DKT +S +L CVEKG+A P E D+L +E+LDTNKCYILDCG+EVF
Sbjct: 233 GFAPLPRKTANDEDKTYNSDITRLFCVEKGQANPVEGDTLKREMLDTNKCYILDCGIEVF 292
Query: 241 VWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVMEGFETVMFRSKFDSWPQTTNAAM 300
VW+GR TSLD+RK AS + +E++ S+ RPKSQ+IR++EGFETV FRSKF+SW Q TN +
Sbjct: 293 VWMGRTTSLDDRKIASKAAEEMIRSSERPKSQMIRIIEGFETVPFRSKFESWTQETNTTV 352
Query: 301 PEDGRGKVAALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
EDGRG+VAALL+RQG++V+GL+KA P KEEPQ +IDCTG+LQV
Sbjct: 353 SEDGRGRVAALLQRQGVNVRGLMKAAPPKEEPQVFIDCTGNLQV 396
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/301 (24%), Positives = 133/301 (43%), Gaps = 33/301 (10%)
Query: 16 WLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEGGAAS 75
W GK + ++E G+A ++ + Q R +G E +F + I+ +GG +S
Sbjct: 440 WFGKQSVEEERGSAVSMASKMVESMKFVPAQARIYEGKEPIQFFVIMQSFIV-FKGGISS 498
Query: 76 GFKHVEAE---------EHKTRLFVCKG---KHVVYVKEVPFARSSLNHDDIFILDTESK 123
G+K AE E+ LF +G +++ ++ P A +SLN +IL +S
Sbjct: 499 GYKKYIAEKEVDDDTYNENGVALFRIQGSGPENMQAIQVDPVA-ASLNSSYYYILHNDSS 557
Query: 124 IFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFA 183
+F + G+ S+ ++ A + IK + ++G SES +FW L GG A
Sbjct: 558 VFTWAGNLSTATDQELAERQLDLIKPNQQS-----RAQKEG-----SESEQFWELLGGKA 607
Query: 184 PLPRKTVSDDDKTIDSHPPKLLCV-EKGKAEPFETDSLTKELLDTNKCYILDCGLEVFVW 242
+ ++ K + P C K + E + T++ L T +I+DC E+FVW
Sbjct: 608 EYSSQKLT---KEPERDPHLFSCTFTKEVLKVTEIYNFTQDDLMTEDIFIIDCHSEIFVW 664
Query: 243 IGRNTSLDERKSASGSTDELVSSTN-----RPKSQIIRVMEGFETVMFRSKFDSWPQTTN 297
+G+ + A ++ + + P++ I +MEG E F F SW + +
Sbjct: 665 VGQEVVPKNKLLALTIGEKFIEKDSLLEKLSPEAPIYVIMEGGEPSFFTRFFTSWDSSKS 724
Query: 298 A 298
A
Sbjct: 725 A 725
>VIL2_ARATH (O81644) Villin 2
Length = 976
Score = 452 bits (1163), Expect = e-127
Identities = 213/345 (61%), Positives = 273/345 (78%), Gaps = 2/345 (0%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
TT +K GA DIH+W+GKDTSQDEAG AA+KTVELDAVLGGRAVQ+RE+QGHE+ KFLS
Sbjct: 51 TTQNKGGAYLFDIHFWIGKDTSQDEAGTAAVKTVELDAVLGGRAVQHREIQGHESDKFLS 110
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
YFKPCIIP EGG ASGFK VE E +TRL+ CKGK + +K+VPFARSSLNHDD+FILDT
Sbjct: 111 YFKPCIIPLEGGVASGFKTVEEEVFETRLYTCKGKRAIRLKQVPFARSSLNHDDVFILDT 170
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
E KI+QFNG+NS+IQERAKALEVVQY+KD YH+G C+VA ++DG+L +S+SG FW LFG
Sbjct: 171 EEKIYQFNGANSNIQERAKALEVVQYLKDKYHEGTCDVAIVDDGKLDTESDSGAFWVLFG 230
Query: 181 GFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVF 240
GFAP+ RK +DDD +S PPKL C+ GK EP + D L+K +L+ KCY+LDCG E++
Sbjct: 231 GFAPIGRKVANDDDIVPESTPPKLYCITDGKMEPIDGD-LSKSMLENTKCYLLDCGAEIY 289
Query: 241 VWIGRNTSLDERKSASGSTDELVSSTNRPK-SQIIRVMEGFETVMFRSKFDSWPQTTNAA 299
+W+GR T +DERK+AS S +E ++S NRPK + + RV++G+E+ F+S FDSWP +
Sbjct: 290 IWVGRVTQVDERKAASQSAEEFLASENRPKATHVTRVIQGYESHSFKSNFDSWPSGSATP 349
Query: 300 MPEDGRGKVAALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
E+GRGKVAALLK+QG+ +KG+ K+ PV E+ P ++ G L+V
Sbjct: 350 GNEEGRGKVAALLKQQGVGLKGIAKSAPVNEDIPPLLESGGKLEV 394
Score = 81.3 bits (199), Expect = 4e-15
Identities = 81/318 (25%), Positives = 132/318 (41%), Gaps = 41/318 (12%)
Query: 16 WLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEGGAAS 75
W GK + ++ A + L GR VQ R +G E +F++ F+P ++ +GG +S
Sbjct: 439 WFGKKSIPEDQDTAIRLANTMSNSLKGRPVQGRIYEGKEPPQFVALFQPMVV-LKGGLSS 497
Query: 76 GFKHVEAEEHKTRLFVCK-----------GKHVVYVKEVPFARSSLNHDDIFILDTESKI 124
G+K E T G H +V +SLN + F+L + + +
Sbjct: 498 GYKSSMGESESTDETYTPESIALVQVSGTGVHNNKAVQVETVATSLNSYECFLLQSGTSM 557
Query: 125 FQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAP 184
F ++G+ S+ ++ A +V +++K I +ES FW GG
Sbjct: 558 FLWHGNQSTHEQLELATKVAEFLKP----------GITLKHAKEGTESSTFWFALGGKQN 607
Query: 185 LPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIG 244
K S + TI +GK + E + ++ L T Y LD EVFVW+G
Sbjct: 608 FTSKKASSE--TIRDPHLFSFAFNRGKFQVEEIYNFAQDDLLTEDIYFLDTHAEVFVWVG 665
Query: 245 RNTSLDERKSA----------SGSTDELVSSTNRPKSQIIRVMEGFETVMFRSKFDSWPQ 294
+ E+++ +GS + L PK I ++ EG E F + F SW
Sbjct: 666 QCVEPKEKQTVFEIGQKYIDLAGSLEGL-----HPKVPIYKINEGNEPCFFTTYF-SW-D 718
Query: 295 TTNAAMPEDGRGKVAALL 312
T A + + K A+LL
Sbjct: 719 ATKAIVQGNSFQKKASLL 736
>VIL3_ARATH (O81645) Villin 3
Length = 966
Score = 435 bits (1118), Expect = e-121
Identities = 206/345 (59%), Positives = 270/345 (77%), Gaps = 2/345 (0%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
TT +K GA DIH+W+GKDTSQDEAG AA+KTVELDA LGGRAVQYRE+QGHE+ KFLS
Sbjct: 53 TTQNKGGAYLFDIHFWIGKDTSQDEAGTAAVKTVELDAALGGRAVQYREIQGHESDKFLS 112
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
YFKPCIIP EGG ASGFK E EE +TRL+ CKGK V++K+VPFARSSLNHDD+FILDT
Sbjct: 113 YFKPCIIPLEGGVASGFKKPEEEEFETRLYTCKGKRAVHLKQVPFARSSLNHDDVFILDT 172
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
+ KI+QFNG+NS+IQERAKAL V+QY+KD +H+G +VA ++DG+L +S+SGEFW LFG
Sbjct: 173 KEKIYQFNGANSNIQERAKALVVIQYLKDKFHEGTSDVAIVDDGKLDTESDSGEFWVLFG 232
Query: 181 GFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVF 240
GFAP+ RK S+D+ ++ PPKL + G+ E + D L+K +L+ NKCY+LDCG E+F
Sbjct: 233 GFAPIARKVASEDEIIPETTPPKLYSIADGQVESIDGD-LSKSMLENNKCYLLDCGSEIF 291
Query: 241 VWIGRNTSLDERKSASGSTDELVSSTNRPK-SQIIRVMEGFETVMFRSKFDSWPQTTNAA 299
+W+GR T ++ERK+A + ++ V+S NRPK ++I RV++G+E F+S FDSWP +
Sbjct: 292 IWVGRVTQVEERKTAIQAAEDFVASENRPKATRITRVIQGYEPHSFKSNFDSWPSGSATP 351
Query: 300 MPEDGRGKVAALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
E+GRGKVAALLK+QG+ +KGL K+ PV E+ P ++ G L+V
Sbjct: 352 ANEEGRGKVAALLKQQGVGLKGLSKSTPVNEDIPPLLEGGGKLEV 396
Score = 87.8 bits (216), Expect = 4e-17
Identities = 83/318 (26%), Positives = 147/318 (46%), Gaps = 41/318 (12%)
Query: 16 WLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEGGAAS 75
W GK+++Q++ A + L GR VQ R +G E +F++ F+ ++ +GG +S
Sbjct: 441 WFGKNSNQEDQETAVRLASTMTNSLKGRPVQARIFEGKEPPQFVALFQHMVV-LKGGLSS 499
Query: 76 GFKHVEAEEHKT---------RLFVCKGKHVVYVK--EVPFARSSLNHDDIFILDTESKI 124
G+K+ E+ + L G V K +V +SLN D F+L + + +
Sbjct: 500 GYKNSMTEKGSSGETYTPESIALIQVSGTGVHNNKALQVEAVATSLNSYDCFLLQSGTSM 559
Query: 125 FQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAP 184
F + G++S+ +++ A +V +++K + ++G +ES FW GG
Sbjct: 560 FLWVGNHSTHEQQELAAKVAEFLKPG-----TTIKHAKEG-----TESSSFWFALGGKQN 609
Query: 185 LPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIG 244
K VS + T+ +GK + E + ++ L T + ++LD EVFVW+G
Sbjct: 610 FTSKKVSSE--TVRDPHLFSFSFNRGKFQVEEIHNFDQDDLLTEEMHLLDTHAEVFVWVG 667
Query: 245 RNTSLDERKSA----------SGSTDELVSSTNRPKSQIIRVMEGFETVMFRSKFDSWPQ 294
+ E+++A +GS + L PK + ++ EG E F + F SW
Sbjct: 668 QCVDPKEKQTAFEIGQRYINLAGSLEGL-----SPKVPLYKITEGNEPCFFTTYF-SW-D 720
Query: 295 TTNAAMPEDGRGKVAALL 312
+T A + + K AALL
Sbjct: 721 STKATVQGNSYQKKAALL 738
>VIL1_ARATH (O81643) Villin 1
Length = 910
Score = 330 bits (846), Expect = 3e-90
Identities = 172/338 (50%), Positives = 229/338 (66%), Gaps = 8/338 (2%)
Query: 10 RHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQ 69
++DIHYWLG D ++ ++ A+ K ++LDA LG VQYREVQG ET+KFLSYFKPCIIP
Sbjct: 62 QYDIHYWLGIDANEVDSILASDKALDLDAALGCCTVQYREVQGQETEKFLSYFKPCIIPV 121
Query: 70 EGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDTESKIFQFNG 129
EG S + E ++ L CKG HVV VKEVPF RSSLNHDD+FILDT SK+F F G
Sbjct: 122 EG-KYSPKTGIAGETYQVTLLRCKGDHVVRVKEVPFLRSSLNHDDVFILDTASKVFLFAG 180
Query: 130 SNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRKT 189
NSS QE+AKA+EVV+YIKD HDG+CEVA+IEDG+ DS++GEFW FGG+AP+P+ +
Sbjct: 181 CNSSTQEKAKAMEVVEYIKDNKHDGRCEVATIEDGKFSGDSDAGEFWSFFGGYAPIPKLS 240
Query: 190 VSDDDKTIDSHPPKLLCVE-KGKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIGRNTS 248
S + + +L ++ KG P T SL K++L+ NKCY+LDC EVFVW+GRNTS
Sbjct: 241 SSTTQEQTQTPCAELFWIDTKGNLHPTGTSSLDKDMLEKNKCYMLDCHSEVFVWMGRNTS 300
Query: 249 LDERKSASGSTDELVSSTNR-PKSQIIRVMEGFETVMFRSKFDSWPQTT-NAAMPEDGRG 306
L ERK++ S++E + R + ++ + EG E FRS F+ WP + A +GR
Sbjct: 301 LTERKTSISSSEEFLRKEGRSTTTSLVLLTEGLENARFRSFFNKWPSDRWSLAFYNEGRE 360
Query: 307 KVAALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
KVAAL K++G DV+ L P +E+ Y +C +L+V
Sbjct: 361 KVAALFKQKGYDVEEL----PDEEDDPLYTNCRDNLKV 394
Score = 71.2 bits (173), Expect = 4e-12
Identities = 70/303 (23%), Positives = 128/303 (42%), Gaps = 29/303 (9%)
Query: 11 HDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQE 70
H ++ W+G ++ Q + A + G +V QG+E +F F+ ++ +
Sbjct: 433 HLLYVWIGCESIQQDRADAITNASAIVGTTKGESVLCHIYQGNEPSRFFPMFQSLVV-FK 491
Query: 71 GGAASGFKHVEAE---------EHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILD 119
GG + +K + AE E+K LF G ++ +V +SLN +IL
Sbjct: 492 GGLSRRYKVLLAEKEKIGEEYNENKASLFRVVGTSPRNMQAIQVNLVATSLNSSYSYILQ 551
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
+ F + G SS + + L+ + Y DT C+ I +G +E+ FW L
Sbjct: 552 YGASAFTWIGKLSSDSDH-EVLDRMLYFLDT----SCQPTYIREG-----NETDTFWNLL 601
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEV 239
GG + P++ + K I+ + E + ++ L T ++LDC EV
Sbjct: 602 GGKSEYPKE--KEMRKQIEEPHLFTCSCSSDVLKVKEIYNFVQDDLTTEDVFLLDCQSEV 659
Query: 240 FVWIGRNTSLDERKSA-----SGSTDELVSSTNRPKSQIIRVMEGFETVMFRSKFDSWPQ 294
+VWIG N+++ ++ A +++ ++ + V EG E F F+ P+
Sbjct: 660 YVWIGSNSNIKSKEEALTLGLKFLEMDILEEGLTMRTPVYVVTEGHEPPFFTRFFEWVPE 719
Query: 295 TTN 297
N
Sbjct: 720 KAN 722
>GELS_DROME (Q07171) Gelsolin precursor
Length = 798
Score = 201 bits (510), Expect = 3e-51
Identities = 117/299 (39%), Positives = 172/299 (57%), Gaps = 13/299 (4%)
Query: 5 KSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKP 64
K L D+H+WLG +TS DEAGAAAI TV+LD +L G VQ+REVQ HE+Q FLSYFK
Sbjct: 109 KDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKN 168
Query: 65 CIIPQEGGAASGFKHVEAE-EHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDTESK 123
I ++GG +GFKHVE + +TRLF KGK V V++V + SS+N D FILD S
Sbjct: 169 GIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSD 228
Query: 124 IFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFA 183
I+ + GS + E+ KA+ I+D H+G+ V ++D D++ F+ + G +
Sbjct: 229 IYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDD--FSTDADKQHFFDVLGSGS 286
Query: 184 --PLPRKTVSDDDKTI---DSHPPKLLCVE----KGKAEPFETDSLTKELLDTNKCYILD 234
+P ++ +D+D D+ L V K K + LT+ +LDT +C+ILD
Sbjct: 287 ADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILD 346
Query: 235 CGLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPK-SQIIRVMEGFETVMFRSKFDSW 292
G +FVW+G+ + E+ A E + + P +QI R++EG E+ F+ FD+W
Sbjct: 347 TGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTW 405
Score = 63.9 bits (154), Expect = 6e-10
Identities = 71/277 (25%), Positives = 115/277 (40%), Gaps = 29/277 (10%)
Query: 25 EAGAAAIKTVELDAVLGGR-AVQYREVQGHETQKFLSYFKPCIIPQEGGAASGFKHVEAE 83
+A AAA K + ++G + + + QGHE + F FK G + F +
Sbjct: 517 KASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFK-------GKLLTSFTALPVT 569
Query: 84 EHKTRLFVCKG--KHVVYVKEVPFARSSLNHDDIFILDT--ESKIFQFNGSNSSIQERAK 139
+LF +G + V+ EV SSL D F+L + KI+ +NG +S E+
Sbjct: 570 ---AQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQA 626
Query: 140 ALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRKTVSDDDKTIDS 199
A V D + D E+ +E+G +E EFW G R D ++S
Sbjct: 627 A---VDRFSDYWDD--VELEQVEEG-----AEPDEFWEELNGEGQYDRSLGDDGAPLLES 676
Query: 200 HPPKLLCVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIGRNTSLDERKSASGST 259
G + E +E LD++ +LD G E+++W+G S +E +
Sbjct: 677 RLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTA 736
Query: 260 DELVSSTNRPKS----QIIRVMEGFETVMFRSKFDSW 292
+ +S IIRV +G E +F+ F +W
Sbjct: 737 KLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNW 773
>GELS_CHICK (O93510) Gelsolin precursor (Actin-depolymerizing
factor) (ADF) (Brevin) (Homogenin)
Length = 778
Score = 191 bits (485), Expect = 2e-48
Identities = 121/303 (39%), Positives = 172/303 (55%), Gaps = 17/303 (5%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T +SG L++D+H+WLG ++SQDE GAAAI TV++D L G+AVQ+REVQGHE+ FL
Sbjct: 96 TIRQRSGNLQYDLHFWLGDESSQDERGAAAIFTVQMDDYLQGKAVQHREVQGHESSTFLG 155
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK I + GG ASGF+HV E RL KG+ V EVP + S N D FILD
Sbjct: 156 YFKSGIKYKAGGVASGFRHVVPNEVTVQRLLQVKGRRTVRATEVPVSWESFNTGDCFILD 215
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
S I+Q+ GSNS+ QER KA + + I+D +G+ +V E+G +E E +
Sbjct: 216 LGSNIYQWCGSNSNRQERLKATVLAKGIRDNEKNGRAKVFVSEEG-----AEREEMLQVL 270
Query: 180 GGFAPLPRKTVSDDDKTIDSHP--PKLLCVEKGKAE-----PFETDSLTKELLDTNKCYI 232
G LP + SDD KT ++ KL V G + + ++ L+T C+I
Sbjct: 271 GPKPSLP-QGASDDTKTDTANRKLAKLYKVSNGAGNMAVSLVADENPFSQAALNTEDCFI 329
Query: 233 LDCGLE--VFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKF 289
LD G + +FVW GR+ + DERK+A + + + PK ++V+ E ET +F+ F
Sbjct: 330 LDHGTDGKIFVWKGRSANSDERKAALKTATDFIDKMGYPKHTQVQVLPESGETPLFKQFF 389
Query: 290 DSW 292
+W
Sbjct: 390 KNW 392
Score = 108 bits (271), Expect = 2e-23
Identities = 92/300 (30%), Positives = 138/300 (45%), Gaps = 29/300 (9%)
Query: 3 ASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF 62
A K G + I+ W G ++QDE +A TV+LD LGG VQ R VQG E +S F
Sbjct: 479 AGKQGQI---IYTWQGAHSTQDEIATSAFLTVQLDEELGGSPVQKRVVQGKEPPHLMSMF 535
Query: 63 --KPCIIPQEGGAASGFKHVEAEEHKTRLFVCKG--KHVVYVKEVPFARSSLNHDDIFIL 118
KP I+ + G + G + A+ TRLF + E+ A S LN +D F+L
Sbjct: 536 GGKPLIVYKGGTSREGGQTTPAQ---TRLFQVRSSTSGATRAVELDPAASQLNSNDAFVL 592
Query: 119 DTESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGL 178
T S + + G S+ E + A E+++ + + +GR E FW
Sbjct: 593 KTPSAAYLWVGRGSNSAELSGAQELLKVL-------GARPVQVSEGR-----EPDNFWVA 640
Query: 179 FGGFAPLPRKTVSDDDKTIDSHPPKLL-CVEKGKAEPFE--TDSLTKELLDTNKCYILDC 235
GG AP R + DK +D++PP+L C K E LT++ L T+ ILD
Sbjct: 641 LGGKAPY-RTSPRLKDKKMDAYPPRLFACSNKSGRFTIEEVPGDLTQDDLATDDVMILDT 699
Query: 236 GLEVFVWIGRNTSLDERKSASGSTDELVS---STNRPKSQIIRVMEGFETVMFRSKFDSW 292
+VFVWIG++ +E+ A S + ++ ++ + V +G E F F W
Sbjct: 700 WDQVFVWIGKDAQEEEKTEALKSAKRYIETDPASRDKRTPVTLVKQGLEPPTFSGWFLGW 759
>GELS_PIG (P20305) Gelsolin precursor, plasma (Actin-depolymerizing
factor) (ADF) (Brevin) (Fragment)
Length = 772
Score = 187 bits (475), Expect = 3e-47
Identities = 120/304 (39%), Positives = 167/304 (54%), Gaps = 19/304 (6%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T ++G L++D+HYWLG + SQDE+GAAAI TV+LD L GRAVQ+REVQG E+ FL
Sbjct: 90 TVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLG 149
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK + ++GG ASGFKHV E RLF KG+ VV EVP + S N D FILD
Sbjct: 150 YFKSGLKYKKGGVASGFKHVVPNEVAVQRLFQVKGRRVVRATEVPVSWESFNRGDCFILD 209
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
+ I+Q+ GSNS+ ER KA +V + I+D G+ V E+ D+E +
Sbjct: 210 LGNDIYQWCGSNSNRYERLKATQVSKGIRDNERSGRAHVHVSEE-----DAEPAGMLQVL 264
Query: 180 GGFAPLP---RKTVSDDDKTIDSHPPKLLCVEKGKAE-----PFETDSLTKELLDTNKCY 231
G LP TV +D + KL V G + + + L + C+
Sbjct: 265 GPKPTLPEGTEDTVKED--AANRKLAKLYKVSNGAGTMTVSLVADENPFAQGALKSEDCF 322
Query: 232 ILDCGLE--VFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSK 288
ILD G + +FVW G+ + +ERK+A + + +S N PK + V+ EG ET +F+
Sbjct: 323 ILDHGKDGKIFVWKGKQANTEERKAALKTASDFISKMNYPKQTQVSVLPEGGETPLFKQF 382
Query: 289 FDSW 292
F +W
Sbjct: 383 FKNW 386
Score = 110 bits (274), Expect = 7e-24
Identities = 93/302 (30%), Positives = 140/302 (45%), Gaps = 28/302 (9%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G ++QDE A+AI T +LD LGG VQ R VQG E +S F KP II +
Sbjct: 480 IYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYRG 539
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGKH--VVYVKEVPFARSSLNHDDIFILDTESKIFQFN 128
G + G + A TRLF + EV +LN +D F+L T S + +
Sbjct: 540 GTSREGGQTAPA---STRLFQVRASSSGATRAVEVIPKAGALNSNDAFVLKTPSAAYLWV 596
Query: 129 GSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRK 188
G+ +S E+ A E+++ + + + + +G SE FW GG A R
Sbjct: 597 GTGASEAEKTGAQELLRVL-------RAQPVQVAEG-----SEPDSFWEALGGKAAY-RT 643
Query: 189 TVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKEL----LDTNKCYILDCGLEVFVWIG 244
+ DK +D+HPP+L K F + + EL L T+ +LD +VFVW+G
Sbjct: 644 SPRLKDKKMDAHPPRLFAC-SNKIGRFVVEEVPGELMQEDLATDDVMLLDTWDQVFVWVG 702
Query: 245 RNTSLDERKSASGSTDELVSS--TNRPKSQIIRVM-EGFETVMFRSKFDSWPQTTNAAMP 301
+++ +E+ A S + + NR + I V+ +GFE F F W + P
Sbjct: 703 KDSQEEEKTEALTSAKRYIETDPANRDRRTPINVVKQGFEPPSFVGWFLGWDDNYWSVDP 762
Query: 302 ED 303
D
Sbjct: 763 LD 764
>GELS_HORSE (Q28372) Gelsolin (Actin-depolymerizing factor) (ADF)
(Brevin)
Length = 730
Score = 186 bits (473), Expect = 6e-47
Identities = 120/304 (39%), Positives = 170/304 (55%), Gaps = 19/304 (6%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T ++G L++D+HYWLG + SQDE+GAAAI TV+LD L GRAVQ+REVQG E+ FL
Sbjct: 48 TVQLRNGILQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLG 107
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK + ++GG ASGFKHV E RL KG+ VV EVP + S N+ D FILD
Sbjct: 108 YFKSGLKYKKGGVASGFKHVVPNEVVVQRLLQVKGRRVVRATEVPVSWESFNNGDCFILD 167
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
+ I+Q+ GS S+ ER KA +V + I+D G+ +V+ E+G +E +
Sbjct: 168 LGNNIYQWCGSKSNRFERLKATQVSKGIRDNERSGRAQVSVFEEG-----AEPEAMLQVL 222
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCVEK--GKAEPFETDSLTKE------LLDTNKCY 231
G LP T +D D+ KL + K A P + E L + C+
Sbjct: 223 GPKPTLPEAT--EDTVKEDAANRKLAKLYKVSNGAGPMVVSLVADENPFAQGALRSEDCF 280
Query: 232 ILDCGLE--VFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSK 288
ILD G + +FVW G+ +++ERK+A + + +S + PK + V+ EG ET +FR
Sbjct: 281 ILDHGKDGKIFVWKGKQANMEERKAALKTASDFISKMDYPKQTQVSVLPEGGETPLFRQF 340
Query: 289 FDSW 292
F +W
Sbjct: 341 FKNW 344
Score = 105 bits (262), Expect = 2e-22
Identities = 88/302 (29%), Positives = 138/302 (45%), Gaps = 28/302 (9%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G ++QDE A+AI T +LD LGG VQ R VQG E +S F KP I+ +
Sbjct: 438 IYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIVYKG 497
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGKH--VVYVKEVPFARSSLNHDDIFILDTESKIFQFN 128
G + G + A TRLF + E+ +LN +D F+L T S + +
Sbjct: 498 GTSREGGQTAPA---STRLFQVRASSSGATRAVEIIPKAGALNSNDAFVLKTPSAAYLWV 554
Query: 129 GSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRK 188
G+ +S E+ A E+++ + + + + +G SE FW GG A R
Sbjct: 555 GAGASEAEKTGAQELLRVL-------RAQPVQVAEG-----SEPDSFWEALGGKATY-RT 601
Query: 189 TVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKEL----LDTNKCYILDCGLEVFVWIG 244
+ DK +D+HPP+L K F + + E L T+ +LD +VFVW+G
Sbjct: 602 SPRLKDKKMDAHPPRLFAC-SNKIGRFVIEEVPGEFMQEDLATDDVMLLDTWDQVFVWVG 660
Query: 245 RNTSLDERKSASGSTDELVSST---NRPKSQIIRVMEGFETVMFRSKFDSWPQTTNAAMP 301
+++ +E+ A S + + ++ I V +GFE F F W + + P
Sbjct: 661 KDSQDEEKTEALTSAKRYIDTDPAHRDRRTPITVVKQGFEPPSFVGWFLGWDDSYWSVDP 720
Query: 302 ED 303
D
Sbjct: 721 LD 722
>GELS_HUMAN (P06396) Gelsolin precursor, plasma
(Actin-depolymerizing factor) (ADF) (Brevin) (AGEL)
Length = 782
Score = 182 bits (462), Expect = 1e-45
Identities = 120/309 (38%), Positives = 167/309 (53%), Gaps = 29/309 (9%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T ++G L++D+HYWLG + SQDE+GAAAI TV+LD L GRAVQ+REVQG E+ FL
Sbjct: 100 TVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLG 159
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK + ++GG ASGFKHV E RLF KG+ VV EVP + S N+ D FILD
Sbjct: 160 YFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILD 219
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
+ I Q+ GSNS+ ER KA +V + I+D G+ V E+G +E +
Sbjct: 220 LGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEG-----TEPEAMLQVL 274
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCVEK-------------GKAEPFETDSLTKELLD 226
G LP T +D D+ KL + K PF +L E
Sbjct: 275 GPKPALPAGT--EDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSE--- 329
Query: 227 TNKCYILDCGLE--VFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETV 283
C+ILD G + +FVW G+ + +ERK+A + + ++ + PK + V+ EG ET
Sbjct: 330 --DCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETP 387
Query: 284 MFRSKFDSW 292
+F+ F +W
Sbjct: 388 LFKQFFKNW 396
Score = 108 bits (270), Expect = 2e-23
Identities = 91/291 (31%), Positives = 138/291 (47%), Gaps = 28/291 (9%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G ++QDE A+AI T +LD LGG VQ R VQG E +S F KP II +
Sbjct: 490 IYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKG 549
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILDTESKIFQFN 128
G + G + A TRLF + + EV +LN +D F+L T S + +
Sbjct: 550 GTSREGGQTAPA---STRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWV 606
Query: 129 GSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRK 188
G+ +S E+ A E+++ + + + + +G SE FW GG A R
Sbjct: 607 GTGASEAEKTGAQELLRVL-------RAQPVQVAEG-----SEPDGFWEALGGKAAY-RT 653
Query: 189 TVSDDDKTIDSHPPKLLCVEKGKAEPFETDSLTKEL----LDTNKCYILDCGLEVFVWIG 244
+ DK +D+HPP+L K F + + EL L T+ +LD +VFVW+G
Sbjct: 654 SPRLKDKKMDAHPPRLFAC-SNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVG 712
Query: 245 RNTSLDERKSASGSTDELVSS--TNRP-KSQIIRVMEGFETVMFRSKFDSW 292
+++ +E+ A S + + NR ++ I V +GFE F F W
Sbjct: 713 KDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGW 763
>GELS_MOUSE (P13020) Gelsolin precursor, plasma
(Actin-depolymerizing factor) (ADF) (Brevin)
Length = 780
Score = 180 bits (457), Expect = 4e-45
Identities = 114/302 (37%), Positives = 165/302 (53%), Gaps = 15/302 (4%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T ++G L++D+HYWLG + SQDE+GAAAI TV+LD L GRAVQ+REVQG E+ F
Sbjct: 98 TVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESSTFSG 157
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK + ++GG ASGFKHV E RLF KG+ VV EVP + S N+ D FILD
Sbjct: 158 YFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILD 217
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
+ I+Q+ GS S+ ER KA +V + I+D G+ +V E+G E +
Sbjct: 218 LGNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVSEEG-----GEPEAMLQVL 272
Query: 180 GGFAPLPRKTV-SDDDKTIDSHPPKLLCVEKGKAE-----PFETDSLTKELLDTNKCYIL 233
G LP T + + + KL V G + + + L + C+IL
Sbjct: 273 GPKPALPEGTEDTAKEDAANRRLAKLYKVSNGAGSMSVSLVADENPFAQGALRSEDCFIL 332
Query: 234 DCGLE--VFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKFD 290
D G + +FVW G+ +++ERK+A + + +S P+ + V+ EG ET +F+ F
Sbjct: 333 DHGRDGKIFVWKGKQANMEERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFK 392
Query: 291 SW 292
+W
Sbjct: 393 NW 394
Score = 107 bits (266), Expect = 6e-23
Identities = 92/301 (30%), Positives = 139/301 (45%), Gaps = 26/301 (8%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G ++QDE A+AI T +LD LGG VQ R VQG E +S F KP II +
Sbjct: 488 IYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKG 547
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGKH--VVYVKEVPFARSSLNHDDIFILDTESKIFQFN 128
G + G + A RLF + EV +LN +D F+L T S + +
Sbjct: 548 GTSRDGGQTAPA---SIRLFQVRASSSGATRAVEVMPKSGALNSNDAFVLKTPSAAYLWV 604
Query: 129 GSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRK 188
G+ +S E+ A E+++ ++ + +E+G SE FW GG R
Sbjct: 605 GAGASEAEKTGAQELLKVLRSQH-------VQVEEG-----SEPDAFWEALGGKTAY-RT 651
Query: 189 TVSDDDKTIDSHPPKLLCVEK--GKAEPFET-DSLTKELLDTNKCYILDCGLEVFVWIGR 245
+ DK +D+HPP+L G+ E L +E L T+ +LD +VFVW+G+
Sbjct: 652 SPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGK 711
Query: 246 NTSLDERKSASGSTDELVSS--TNRP-KSQIIRVMEGFETVMFRSKFDSWPQTTNAAMPE 302
++ +E+ A S + + NR ++ I V +GFE F F W + P
Sbjct: 712 DSQEEEKTEALTSAKRYIETDPANRDRRTPITVVRQGFEPPSFVGWFLGWDDNYWSVDPL 771
Query: 303 D 303
D
Sbjct: 772 D 772
>GELS_HOMAM (Q27319) Gelsolin, cytoplasmic (Actin-depolymerizing
factor) (ADF)
Length = 754
Score = 173 bits (438), Expect = 7e-43
Identities = 109/306 (35%), Positives = 164/306 (52%), Gaps = 20/306 (6%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T +G L D+H+WLG +TSQDEAG AAIKTVELD LGG VQ+REV+GHET FLS
Sbjct: 46 TRDVNGNLSWDLHFWLGSETSQDEAGTAAIKTVELDDQLGGVPVQHREVEGHETSLFLSR 105
Query: 62 FKPCIIPQEGGAASGFKHVEAEE-HKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
FK + +GG ASGF HV+ + + RLF KG+ + +++V S+N D FILD
Sbjct: 106 FKKGVRYLKGGVASGFHHVDPDAPYPARLFHVKGRRNIRIRQVEVGVGSMNKGDCFILDC 165
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
S+++ + G +S +R KA++ ++ H GK +V I++ + SE+GE G
Sbjct: 166 GSQVYAYMGPSSRKMDRLKAIQAANPVRADDHAGKAKVIVIDE--TASGSEAGESSPGLG 223
Query: 181 GFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFETDS-------------LTKELLDT 227
G +P V+D+D +D + V D L + +LD+
Sbjct: 224 GGSP---DDVADEDTGVDDSAFERSEVNVVTLHHIFEDGDGVIQTNMIGEKPLLQSMLDS 280
Query: 228 NKCYILDCGLEVFVWIGRNTSLDER-KSASGSTDELVSSTNRPKSQIIRVMEGFETVMFR 286
C++LD G+ V+VWIG +S E+ KS + + + + RV+E E +F+
Sbjct: 281 GDCFLLDTGVGVYVWIGSGSSKKEKVKSMELAAGYMEKKGYPTYTNVQRVVEKAEPAVFK 340
Query: 287 SKFDSW 292
+ F +W
Sbjct: 341 AYFKTW 346
Score = 122 bits (306), Expect = 1e-27
Identities = 95/302 (31%), Positives = 151/302 (49%), Gaps = 31/302 (10%)
Query: 6 SGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPC 65
+G R+ +++W G +SQDE ++AI TV LD L G+AVQ R VQG+E FL FK
Sbjct: 442 NGNERYILYFWQGCASSQDEKASSAIHTVRLDNELCGKAVQVRVVQGYEPAHFLRIFKGR 501
Query: 66 IIPQEGGAASGFKHVEAEE----HKTRLFVCKG-----KHVVYVKEVPFARSSLNHDDIF 116
++ GG ASGFK+V + TRLF +G + EV SLN DD+F
Sbjct: 502 MVIFLGGKASGFKNVHDHDTYDVDGTRLFRVRGTCDFDTRAIQQTEV---AGSLNSDDVF 558
Query: 117 ILDTESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFW 176
+L+T K + + G +S +E+A +VV+ + G+ ++ ++ +G E +FW
Sbjct: 559 VLETPGKTYLWIGKGASEEEKAMGEKVVELVS----PGR-DMVTVAEG-----EEDDDFW 608
Query: 177 GLFGGFAPLPRKTVSDDDKTIDSHPPKLLCV--EKGKAEPFETDSLTKELLDTNKCYILD 234
G GG +T D D+ + +P C G E +E L+ + +LD
Sbjct: 609 GGLGGKGDY--QTARDLDRPL-LYPRLFHCTISPAGCLRVNEMSDFAQEDLNEDDVMVLD 665
Query: 235 CGLEVFVWIGRNTSLDERKSASGSTDELVSS--TNR--PKSQIIRVMEGFETVMFRSKFD 290
G EV+VW+G+ + E++ A + + + T R + I+R+ +G E F S F
Sbjct: 666 SGDEVYVWVGQGSDDQEKEKAFTMAENYIKTDPTERTLDATVILRINQGEEPAAFTSIFP 725
Query: 291 SW 292
+W
Sbjct: 726 AW 727
>VIL1_MOUSE (Q62468) Villin 1
Length = 826
Score = 171 bits (432), Expect = 3e-42
Identities = 119/360 (33%), Positives = 176/360 (48%), Gaps = 33/360 (9%)
Query: 6 SGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPC 65
S L +DIHYW+G+D+SQDE GAAAI T ++D L GRAVQ+REVQG+E++ F SYFK
Sbjct: 54 SSTLSYDIHYWIGQDSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGNESETFRSYFKQG 113
Query: 66 IIPQEGGAASGFKHVEAEE-HKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDTESKI 124
++ ++GG ASG KHVE RL KGK V EV + S N D+F+LD I
Sbjct: 114 LVIRKGGVASGMKHVETNSCDVQRLLHVKGKRNVLAGEVEMSWKSFNRGDVFLLDLGKLI 173
Query: 125 FQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGG-FA 183
Q+NG S+ ER + + + + I+D G+ V ++ + + +S + +
Sbjct: 174 IQWNGPESNRMERLRGMPLAKEIRDQERGGRTYVGVVDGEK---EGDSPQLMAIMNHVLG 230
Query: 184 PLPRKTVSDDDKTIDSHPPKLLCV-----EKGK--AEPFETDSLTKELLDTNKCYILD-C 235
P + D ++ L + +GK T LT++LL CYILD
Sbjct: 231 PRKELKAAISDSVVEPAAKAALKLYHVSDSEGKLVVREVATRPLTQDLLKHEDCYILDQG 290
Query: 236 GLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKFDSW-- 292
GL++FVW G+N + ER A + + P S + V +G E+ +F+ F W
Sbjct: 291 GLKIFVWKGKNANAQERSGAMSQALNFIKAKQYPPSTQVEVQNDGAESPIFQQLFQKWTV 350
Query: 293 PQTTNAAMPEDGRGKVAALLKRQGLDVKGLVKADPVKEEPQPYI--------DCTGHLQV 344
P T+ G VA + + VK D + QP + D +G +QV
Sbjct: 351 PNRTSGLGKTHTVGSVAKVEQ---------VKFDALTMHVQPQVAAQQKMVDDGSGEVQV 401
Score = 96.7 bits (239), Expect = 8e-20
Identities = 82/288 (28%), Positives = 134/288 (46%), Gaps = 24/288 (8%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEGG 72
++ W G SQDE A+A + V LD VQ R G E +S FK ++ +GG
Sbjct: 442 LYIWQGSQASQDEIAASAYQAVLLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGG 501
Query: 73 AASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILDTESKIFQFNGS 130
+ K+ TRLF +G + K EV +SLN +D+FIL T S + + G
Sbjct: 502 TSR--KNNLEPVPSTRLFQVRGTNADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGK 559
Query: 131 NSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPR-KT 189
S ER E+ + + DT ++ E ++ E FW GG AP K
Sbjct: 560 GCSGDER----EMAKMVADT-------ISRTEKQVVVEGQEPANFWMALGGKAPYANTKR 608
Query: 190 VSDDDKTIDSHPPKLL--CVEKGKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIGRNT 247
+ ++++ I P+L + G+ E ++ L+ ++LD +VF WIG++
Sbjct: 609 LQEENQVI---TPRLFECSNQTGRFLATEIFDFNQDDLEEEDVFLLDVWDQVFFWIGKHA 665
Query: 248 SLDERKSASGSTDELVSS--TNRP-KSQIIRVMEGFETVMFRSKFDSW 292
+ +E+K+A+ + E + + NR ++ II V +G E F F +W
Sbjct: 666 NEEEKKAAATTVQEYLKTHPGNRDLETPIIVVKQGHEPPTFTGWFLAW 713
>SEVE_DICDI (P10733) Severin
Length = 362
Score = 170 bits (430), Expect = 6e-42
Identities = 119/299 (39%), Positives = 158/299 (52%), Gaps = 31/299 (10%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T + +L+HDIH++LG T+QDEAG AA KTVELD LGG +QYR+ Q +E+ FLS
Sbjct: 77 TFKEGNSLKHDIHFFLGTFTTQDEAGTAAYKTVELDDFLGGAPIQYRQCQSYESPSFLSL 136
Query: 62 FKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDTE 121
F P GG SGF HV+ E+K RL G V EVP A SSLN D F+LD
Sbjct: 137 F-PKYFILSGGVESGFNHVKPTEYKPRLLHISGDKNAKVAEVPLATSSLNSGDCFLLDAG 195
Query: 122 SKIFQFNGSNSSIQERAKALEVVQYIKDTYHDG--KCEVASIEDGRLMADSESGEFWGLF 179
I+QFNGS SS QE+ KA EV + I D G K EV D + A EFW L
Sbjct: 196 LTIYQFNGSKSSPQEKNKAAEVARAI-DAERKGLPKVEVFCETDSDIPA-----EFWKLL 249
Query: 180 GGFAPLPRKTVSDDDKTID--------SHPPKLLCVEKGKAEPFETDSLTKELLDTNKCY 231
GG + K + K+ S K V +GK + K L + +
Sbjct: 250 GGKGAIAAKHETAPTKSEKVLYKLSDASGSLKFSEVSRGK--------INKSSLKSEDVF 301
Query: 232 ILDCGLEVFVWIGRNTSLDERKSA-SGSTDELVSSTNRPKSQIIRVME-----GFETVM 284
I+D G E++ WIG +S +E+K+A S +T LV++ + I+RV+E FET++
Sbjct: 302 IIDLGNEIYTWIGSKSSPNEKKTAFSHATQYLVNNKRCEYTPIVRVLENGTNQSFETLL 360
>ADSV_HUMAN (Q9Y6U3) Adseverin (Scinderin)
Length = 715
Score = 166 bits (421), Expect = 6e-41
Identities = 121/361 (33%), Positives = 183/361 (50%), Gaps = 29/361 (8%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
TA S + +H+WLGK+ SQDE+ AAAI TV++D LGG+ VQ RE+QG+E+ F+SY
Sbjct: 51 TAKTSRGFTYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSY 110
Query: 62 FKPCIIPQEGGAASGFKHVEAEE-HKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
FK + + GG ASG HV + RL KG+ VV EVP + S N D FI+D
Sbjct: 111 FKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDL 170
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
++I+Q+ GS+ + ER KA +V I+ G+ E+ +E+G SE E + G
Sbjct: 171 GTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEG-----SEPSELIKVLG 225
Query: 181 GFAPLPRKTVSDDDKTI----DSHPPKLLCVEKGKAE-----PFETDSLTKELLDTNKCY 231
LP DDD I + KL V E + + +L + +C+
Sbjct: 226 EKPELP--DGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECF 283
Query: 232 ILDCGL--EVFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSK 288
ILD G ++FVW G++ + ERK+A + +E + N K+ I+V+ EG ET +F+
Sbjct: 284 ILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQF 343
Query: 289 FDSWPQTTNAAMPEDGRGKV-----AALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQ 343
F W + DG GKV A +K+ D L + + + D +G ++
Sbjct: 344 FKDWRDKDQS----DGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVE 399
Query: 344 V 344
+
Sbjct: 400 I 400
Score = 95.1 bits (235), Expect = 2e-19
Identities = 83/290 (28%), Positives = 126/290 (42%), Gaps = 26/290 (8%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G + ++DE +A TV+LD LGG+AVQ R QG E LS F KP II +
Sbjct: 437 IYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKN 496
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGK--HVVYVKEVPFARSSLNHDDIFILDTESKIFQFN 128
G + G +A TRLF + + + EV +SLN +D+F+L
Sbjct: 497 GTSKKG---GQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIW 553
Query: 129 GSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPRK 188
+ QE K E V + KC+ I++G E EFW GG
Sbjct: 554 VGKGASQEEEKGAEYVASVL------KCKTLRIQEG-----EEPEEFWNSLGGKKDYQTS 602
Query: 189 TVSDDDKTIDSHPPKLL-CVEKGKAEPFE--TDSLTKELLDTNKCYILDCGLEVFVWIGR 245
+ + + HPP+L C K E T++ L + +LD ++F+WIG+
Sbjct: 603 PLLETQ--AEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGK 660
Query: 246 NTSLDERKSASGSTD---ELVSSTNRPKSQIIRVMEGFETVMFRSKFDSW 292
+ + E+K + S E S ++ I+ + +G E F F W
Sbjct: 661 DANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 710
>ADVL_HUMAN (O75366) Advillin (p92)
Length = 819
Score = 166 bits (420), Expect = 8e-41
Identities = 107/302 (35%), Positives = 156/302 (51%), Gaps = 12/302 (3%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
+T + L DIH+W+GKD+SQDE AAI T +LD LGG VQ+REVQ HE+ F
Sbjct: 47 STRRVASLLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRG 106
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK II ++GG ASG KHVE + RL KGK + EV + S N D+F+LD
Sbjct: 107 YFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLD 166
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
I Q+NG S+ ER KA+ + + I+D G+ E+ IE + A E +
Sbjct: 167 LGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMKVLQDT 226
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCV-----EKGKAEPFE--TDSLTKELLDTNKCYI 232
G + + TV D+ ID + + G+ E T L ++LL+ + CYI
Sbjct: 227 LGRRSIIKPTVPDE--IIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYI 284
Query: 233 LD-CGLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPKS-QIIRVMEGFETVMFRSKFD 290
LD G +++VW G+ + E+++A + + P S + V +G E+ MF+ F
Sbjct: 285 LDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQ 344
Query: 291 SW 292
W
Sbjct: 345 KW 346
Score = 112 bits (279), Expect = 2e-24
Identities = 87/297 (29%), Positives = 137/297 (45%), Gaps = 20/297 (6%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T +G H ++ W + SQDE A+A + VE+D G AVQ R G E + F++
Sbjct: 429 TYEVNGKPHHILYIWQDRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAI 488
Query: 62 FKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILD 119
FK ++ EGG + K + RLF G K EVP SSLN +D+F+L
Sbjct: 489 FKGKLVIFEGGTSR--KGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLR 546
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
T+++ + + G SS ERA A E+ + D + ++ +G+ E EFW L
Sbjct: 547 TQAEHYLWYGKGSSGDERAMAKELASLLCDGSEN------TVAEGQ-----EPAEFWDLL 595
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCVEK-GKAEPFETDSLTKELLDTNKCYILDCGLE 238
GG P + +D C K G+ E T++ L+ +LD +
Sbjct: 596 GGKTPYANDKRLQQE-ILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQ 654
Query: 239 VFVWIGRNTSLDERKSASGSTDELV---SSTNRPKSQIIRVMEGFETVMFRSKFDSW 292
VF+WIG + E++SA + + + S P + I+ + +GFE +F F +W
Sbjct: 655 VFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAW 711
>ADSV_MOUSE (Q60604) Adseverin (Scinderin) (Gelsolin-like protein)
Length = 715
Score = 164 bits (414), Expect = 4e-40
Identities = 112/319 (35%), Positives = 165/319 (51%), Gaps = 22/319 (6%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T S + +H+WLGK+ SQDE+ AAAI TV++D LGG+ VQ RE+QG+E+ F+ Y
Sbjct: 51 TTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGY 110
Query: 62 FKPCIIPQEGGAASGFKHVEAEE-HKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
FK + + GG ASG HV + RL KG+ VV EVP + S N D FI+D
Sbjct: 111 FKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDL 170
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
++I+Q+ GS+ + ER KA +V I+D G+ ++ +E+G SE E + G
Sbjct: 171 GTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEG-----SEPSELMKVLG 225
Query: 181 GFAPLPRKTVSDDDKTID---SHPPKLLCVEKGKAE-----PFETDSLTKELLDTNKCYI 232
LP +DDD D KL V E + + +L + +C+I
Sbjct: 226 RKPELPDGD-NDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFI 284
Query: 233 LDCGL--EVFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKF 289
LD G ++FVW G+N + ERK+A + +E + + I+V+ EG ET +F+ F
Sbjct: 285 LDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFF 344
Query: 290 DSWPQTTNAAMPEDGRGKV 308
W + DG GKV
Sbjct: 345 KDWKDKDQS----DGFGKV 359
Score = 95.1 bits (235), Expect = 2e-19
Identities = 85/291 (29%), Positives = 133/291 (45%), Gaps = 28/291 (9%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G + ++DE +A TV+LD LGG+AVQ R QG E LS F KP II +
Sbjct: 437 IYTWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKN 496
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGK--HVVYVKEVPFARSSLNHDDIFILD-TESKIFQF 127
G + K +A TRLF + + + EV +SLN +D F+L + F +
Sbjct: 497 G---TSKKEGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNGFIW 553
Query: 128 NGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPR 187
G +S +E A +Y+ D KC+ + I++G+ E EFW GG
Sbjct: 554 IGKGASQEEEKGA----EYVADVL---KCKASRIQEGK-----EPEEFWNSLGGRGDYQT 601
Query: 188 KTVSDDDKTIDSHPPKLL-CVEKGKAEPFE--TDSLTKELLDTNKCYILDCGLEVFVWIG 244
+ + + HPP+L C K E T++ L + +LD ++F+WIG
Sbjct: 602 SPLL--ETRAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIG 659
Query: 245 RNTSLDERKSASGSTD---ELVSSTNRPKSQIIRVMEGFETVMFRSKFDSW 292
++ + E+K + S E S ++ I+ + +G E F F W
Sbjct: 660 KDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 710
Score = 43.5 bits (101), Expect = 8e-04
Identities = 40/153 (26%), Positives = 72/153 (46%), Gaps = 21/153 (13%)
Query: 10 RHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQ 69
R++ W+GK SQ+E A + VL +A + +E G E ++F +
Sbjct: 547 RNNGFIWIGKGASQEEEKGAEY----VADVLKCKASRIQE--GKEPEEFWNSL------- 593
Query: 70 EGG----AASGFKHVEAEEHKTRLFVCKGKHVVY-VKEVP--FARSSLNHDDIFILDTES 122
GG S AE+H RL+ C K + ++EVP F + L DD+ +LD
Sbjct: 594 -GGRGDYQTSPLLETRAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWE 652
Query: 123 KIFQFNGSNSSIQERAKALEVVQYIKDTYHDGK 155
+IF + G +++ E+ ++++ + +T G+
Sbjct: 653 QIFIWIGKDANEVEKKESVKSAKMYLETDPSGR 685
>VIL1_HUMAN (P09327) Villin 1
Length = 826
Score = 162 bits (411), Expect = 9e-40
Identities = 115/356 (32%), Positives = 173/356 (48%), Gaps = 25/356 (7%)
Query: 6 SGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPC 65
+ +L +DIHYW+G+D+S DE GAAAI T ++D L GRAVQ+REVQG+E++ F YFK
Sbjct: 54 ASSLSYDIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQG 113
Query: 66 IIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILDTESKI 124
++ ++GG ASG KHVE + RL KGK V EV + S N D+F+LD I
Sbjct: 114 LVIRKGGVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLI 173
Query: 125 FQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGG--- 181
Q+NG S+ ER + + + + I+D G+ V ++ +A + E G
Sbjct: 174 IQWNGPESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRR 233
Query: 182 --FAPLPRKTVSDDDKTIDSHPPKLLCVEKGK----AEPFETDSLTKELLDTNKCYILD- 234
A +P V K KL V + T LT++LL CYILD
Sbjct: 234 ELKAAVPDTVVEPALKA----ALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQ 289
Query: 235 CGLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKFDSWP 293
GL+++VW G+ + E+K A + + P S + V +G E+ +F+ F W
Sbjct: 290 GGLKIYVWKGKKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKW- 348
Query: 294 QTTNAAMPEDGRGKV-----AALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
A+ G GK A +++ D + V + + D +G +QV
Sbjct: 349 ---TASNRTSGLGKTHTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQV 401
Score = 102 bits (254), Expect = 1e-21
Identities = 84/287 (29%), Positives = 134/287 (46%), Gaps = 22/287 (7%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEGG 72
++ W G SQDE A+A + V LD G VQ R G E +S FK ++ +GG
Sbjct: 442 LYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGG 501
Query: 73 AASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILDTESKIFQFNGS 130
S ++E TRLF +G K EVP + LN +D+F+L T+S + + G
Sbjct: 502 -TSRTNNLETGP-STRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGK 559
Query: 131 NSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAPLPR-KT 189
S ER E+ + + DT ++ E ++ E FW GG AP K
Sbjct: 560 GCSGDER----EMAKMVADT-------ISRTEKQVVVEGQEPANFWMALGGKAPYANTKR 608
Query: 190 VSDDDKTIDSHPPKLLCVEK-GKAEPFETDSLTKELLDTNKCYILDCGLEVFVWIGRNTS 248
+ +++ I P C K G+ E ++ L+ + ++LD +VF WIG++ +
Sbjct: 609 LQEENLVIT--PRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHAN 666
Query: 249 LDERKSASGSTDELVS---STNRPKSQIIRVMEGFETVMFRSKFDSW 292
+E+K+A+ + E + S P++ II V +G E F F +W
Sbjct: 667 EEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAW 713
>ADSV_BOVIN (Q28046) Adseverin (Scinderin) (SC)
Length = 715
Score = 162 bits (410), Expect = 1e-39
Identities = 118/360 (32%), Positives = 180/360 (49%), Gaps = 27/360 (7%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T S + +H+WLGK+ +QDE+ AAAI TV++D LGG+ VQ RE+QG+E+ F+ Y
Sbjct: 51 TTQASRGFTYRLHFWLGKECTQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESTDFVGY 110
Query: 62 FKPCIIPQEGGAASGFKHVEAEE-HKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
FK + + GG ASG HV + RL KG+ VV EVP + S N D FI+D
Sbjct: 111 FKGGLKYKAGGVASGLNHVLTNDLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDL 170
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
++I+Q+ GS+ + ER KA +V I+D G+ ++ +E+G SE E + G
Sbjct: 171 GTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRAQLIVVEEG-----SEPSELTKVLG 225
Query: 181 GFAPLPRKTVSDDDKTID---SHPPKLLCVEKGKAE-----PFETDSLTKELLDTNKCYI 232
P R DDD D KL V E + + +L + +C+I
Sbjct: 226 E-KPKLRDGEDDDDIKADITNRKMAKLYMVSDASGSMKVSLVAEENPFSMAMLLSEECFI 284
Query: 233 LDCGL--EVFVWIGRNTSLDERKSASGSTDELVSSTNRPKSQIIRVM-EGFETVMFRSKF 289
LD G ++FVW G++ + ERK+A + +E + N + I+V+ EG ET +F+ F
Sbjct: 285 LDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFF 344
Query: 290 DSWPQTTNAAMPEDGRGKV-----AALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
W + DG GKV A +K+ D L + + + D +G +Q+
Sbjct: 345 KDWRDRDQS----DGFGKVYVTEKVAHVKQIPFDASKLHSSPQMAAQHHVVDDGSGKVQI 400
Score = 96.7 bits (239), Expect = 8e-20
Identities = 86/294 (29%), Positives = 132/294 (44%), Gaps = 34/294 (11%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSYF--KPCIIPQE 70
I+ W G + ++DE +A TV+LD LGG+AVQ R QG E LS F KP II +
Sbjct: 437 IYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPAHLLSLFKDKPLIIYKN 496
Query: 71 GGAASGFKHVEAEEHKTRLFVCKGK--HVVYVKEVPFARSSLNHDDIFILDTESKIFQFN 128
G + K +A RLF + + + EV +SLN +D+F+L K+ Q N
Sbjct: 497 G---TSKKEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDVFVL----KLRQNN 549
Query: 129 G----SNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGFAP 184
G S QE K E V + KC+ ++I++G+ E EFW GG
Sbjct: 550 GYIWIGKGSTQEEEKGAEYVASVL------KCKTSTIQEGK-----EPEEFWNSLGGKKD 598
Query: 185 LPRKTVSDDDKTIDSHPPKLL-CVEKGKAEPFE--TDSLTKELLDTNKCYILDCGLEVFV 241
+ + + HPP+L C K E T++ L + +LD ++F+
Sbjct: 599 YQTSPLLESQ--AEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFI 656
Query: 242 WIGRNTSLDERKSASGSTD---ELVSSTNRPKSQIIRVMEGFETVMFRSKFDSW 292
WIG++ + E+ + S E S ++ I+ + +G E F F W
Sbjct: 657 WIGKDANEVEKSESLKSAKIYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 710
>ADVL_MOUSE (O88398) Advillin (p92) (Actin-binding protein DOC6)
Length = 819
Score = 160 bits (406), Expect = 3e-39
Identities = 116/355 (32%), Positives = 170/355 (47%), Gaps = 13/355 (3%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
+T L +IH+W+GKD+SQDE AAI T +LD LGG VQ+REVQ HE+ F
Sbjct: 47 STRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRG 106
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKT-RLFVCKGKHVVYVKEVPFARSSLNHDDIFILD 119
YFK II ++GG ASG KHVE + RL KGK + EV + S N D+F+LD
Sbjct: 107 YFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLD 166
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
I Q+NG S+ ER KA+ + + I+D G+ E+ IE + A
Sbjct: 167 LGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDT 226
Query: 180 GGFAPLPRKTVSDDDKTIDSHPPKLLCVEKGKAEPFE-----TDSLTKELLDTNKCYILD 234
G + + VSD+ +L A T L ++LL+ + CYILD
Sbjct: 227 LGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILD 286
Query: 235 -CGLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPKS-QIIRVMEGFETVMFRSKFDSW 292
G +++VW G+ + E+++A + + P S + V +G E+ MF+ F W
Sbjct: 287 QSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKW 346
Query: 293 ---PQTTNAAMPEDGRGKVAALLKRQGLDVKGLVKADPVKEEPQPYIDCTGHLQV 344
QTT GK+A + + + DV L V + + D G ++V
Sbjct: 347 SVKDQTTGLG-KIFSTGKIAKIFQDK-FDVSLLHTKPEVAAQERMVDDGKGQVEV 399
Score = 110 bits (274), Expect = 7e-24
Identities = 91/302 (30%), Positives = 138/302 (45%), Gaps = 30/302 (9%)
Query: 2 TASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLSY 61
T +G + ++ W G+ S+DE A+A + VE+D VQ R G E + F++
Sbjct: 429 TYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDRAPVQVRVSMGKEPRHFMAI 488
Query: 62 FKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFILD 119
FK ++ EGG + K E + RLF G K EV + SSL +D+F+L
Sbjct: 489 FKGKLVIYEGGTSR--KGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLISNDVFLLR 546
Query: 120 TESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLF 179
T+++ + + G SS ERA A E+V + D D ++ +G+ E EFW L
Sbjct: 547 TQAEHYLWYGKGSSGDERAMAKELVDLLCDGNAD------TVAEGQ-----EPPEFWDLL 595
Query: 180 GGFAPLPRKTVSDDDK-----TIDSHPPKLLCVEK-GKAEPFETDSLTKELLDTNKCYIL 233
GG KT +DK T+D C K G+ E T+E L +L
Sbjct: 596 GG------KTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLL 649
Query: 234 DCGLEVFVWIGRNTSLDERKSASGSTDELV---SSTNRPKSQIIRVMEGFETVMFRSKFD 290
D +VF+WIG + E+K A + E + S P + I+ + +GFE F F
Sbjct: 650 DTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFL 709
Query: 291 SW 292
+W
Sbjct: 710 AW 711
>FLIH_HUMAN (Q13045) Flightless-I protein homolog
Length = 1269
Score = 140 bits (354), Expect = 4e-33
Identities = 106/353 (30%), Positives = 162/353 (45%), Gaps = 36/353 (10%)
Query: 1 TTASKSGALRHDIHYWLGKDTSQDEAGAAAIKTVELDAVLGGRAVQYREVQGHETQKFLS 60
T SG+L +I+YW+G + + D+ +AI V L LG RE G E+++FL
Sbjct: 533 TFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQ 592
Query: 61 YFKPCIIPQEGGAASGFKHVEAEEHKTRLFVCKGKHVVYVKEVPFARSSLNHDDIFILDT 120
F I EGG ASGF VE + TR++ GK + ++ VP +SL+ +F+LD
Sbjct: 593 VFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDR 652
Query: 121 ESKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFG 180
I+ + G+ +++ KA + I GK E+ + G+ E EFW G
Sbjct: 653 GLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQ-----ELPEFWEALG 707
Query: 181 GFAPLPRKTVSDDDKTIDSHPPKLLCV---------------------EKGKAEPFETDS 219
G +K V +D PKL V ++ K E
Sbjct: 708 GEPSEIKKHVPED---FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMR 764
Query: 220 LTKELLDTNKCYILDCGLEVFVWIGRNTSLDERKSASGSTDELVSSTNRPK-SQIIRVME 278
L + LLDT YILDC +VF+W+GR + R +A EL +RP+ + + R +E
Sbjct: 765 LLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLE 824
Query: 279 GFETVMFRSKFDSWPQTTNAAMPEDGRGKVAALLKRQGLDVKGLVKADPVKEE 331
G E +F++KF +W + + D A+L+ GL G VK D K++
Sbjct: 825 GTEAQVFKAKFKNW----DDVLTVDYTRNAEAVLQSPGL--SGKVKRDAEKKD 871
Score = 41.2 bits (95), Expect = 0.004
Identities = 66/297 (22%), Positives = 112/297 (37%), Gaps = 36/297 (12%)
Query: 13 IHYWLGKDTSQDEAGAAAIKTVE-LDAVLGGRAVQYREVQGHETQKFLSYFKPCIIPQEG 71
+++W G++ S + +++ G+ R Q E KFLS+FK I G
Sbjct: 984 VYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRG 1043
Query: 72 GAASGFKHVEAEEHKTRLFVCKGKHVVYVK--EVPFARSSLNHDDIFIL-------DTES 122
K V+ + + + + + ++ S LN + FIL D +
Sbjct: 1044 KR----KAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQG 1099
Query: 123 KIFQFNGSNSSIQERAKALEVVQYIKDTYHDGKCEVASIEDGRLMADSESGEFWGLFGGF 182
++ + G S E A +++ + DT + + I +G + FW G
Sbjct: 1100 IVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQV----INEG----EEPENFFWVGIGAQ 1151
Query: 183 APLPRKTVSDDDKTIDSHPPKLLCV-EKGKAEPFE--TDSLTKELLDTNKCYILDCGLEV 239
P DDD H C EKG E +D +L D + +LD G EV
Sbjct: 1152 KPY------DDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDD-IMLLDNGQEV 1204
Query: 240 FVWIGRNTSLDE----RKSASGSTDELVSSTNRPKSQIIRVMEGFETVMFRSKFDSW 292
++W+G TS E K+ + S + ++ V +G E F F +W
Sbjct: 1205 YMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAW 1261
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,942,970
Number of Sequences: 164201
Number of extensions: 1774704
Number of successful extensions: 4353
Number of sequences better than 10.0: 48
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4022
Number of HSP's gapped (non-prelim): 94
length of query: 355
length of database: 59,974,054
effective HSP length: 111
effective length of query: 244
effective length of database: 41,747,743
effective search space: 10186449292
effective search space used: 10186449292
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Medicago: description of AC125477.10