BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC123976.3 - phase: 0
(447 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
YOH5_YEAST (Q08234) Probable ATP-dependent transporter YOL074C/Y... 136 1e-31
ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2... 131 3e-30
ADP1_YEAST (P25371) Probable ATP-dependent permease precursor 130 7e-30
PDRC_YEAST (Q02785) ATP-dependent permease PDR12 124 4e-28
PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin 124 4e-28
PDRA_YEAST (P51533) ATP-dependent permease PDR10 124 6e-28
CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom... 123 1e-27
BFR1_SCHPO (P41820) Brefeldin A resistance protein 122 2e-27
PDRF_YEAST (Q04182) ATP-dependent permease PDR15 121 4e-27
CDR2_CANAL (P78595) Multidrug resistance protein CDR2 121 4e-27
SNQ2_YEAST (P32568) SNQ2 protein 120 5e-27
CDR1_CANAL (P43071) Multidrug resistance protein CDR1 120 5e-27
ABG5_MOUSE (Q99PE8) ATP-binding cassette, sub-family G, member 5... 120 5e-27
CDR4_CANAL (O74676) ABC transporter CDR4 120 9e-27
ABG5_HUMAN (Q9H222) ATP-binding cassette, sub-family G, member 5... 118 4e-26
ABG5_RAT (Q99PE7) ATP-binding cassette, sub-family G, member 5 (... 117 6e-26
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3 117 8e-26
ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8... 111 4e-24
ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4 108 3e-23
ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8... 107 5e-23
>YOH5_YEAST (Q08234) Probable ATP-dependent transporter
YOL074C/YOL075C
Length = 1294
Score = 136 bits (343), Expect = 1e-31
Identities = 81/276 (29%), Positives = 149/276 (53%), Gaps = 38/276 (13%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQ----GDITYNGHRLNEF 233
IL++ + I KP + ++GP SGK++LL ++G+L S + + G I +N +++E
Sbjct: 709 ILQSVNAIFKPGMINAIMGPSGSGKSSLLNLISGRLKSSVFAKFDTSGSIMFNDIQVSEL 768
Query: 234 VPRKTSAYISQNDVHV-GEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAEL 292
+ + +Y+SQ+D H+ +TVKETL ++A R L+E R E+
Sbjct: 769 MFKNVCSYVSQDDDHLLAALTVKETLKYAA-----ALRLHHLTEAERMER---------- 813
Query: 293 DLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGP 352
TD ++ LGL C++ I+G+E +G+SGG+K+RVT G ++
Sbjct: 814 -----------------TDNLIRSLGLKHCENNIIGNEFVKGISGGEKRRVTMGVQLLND 856
Query: 353 TKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE- 411
L +DE ++GLDS T+ I++ L+++ TI++++ QP E F F +++L+++
Sbjct: 857 PPILLLDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPRSELFKRFGNVLLLAKS 916
Query: 412 GQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
G+ + G + ++ +F G+ CP ADF ++
Sbjct: 917 GRTAFNGSPDEMIAYFTELGYNCPSFTNVADFFLDL 952
Score = 128 bits (321), Expect = 3e-29
Identities = 84/289 (29%), Positives = 137/289 (47%), Gaps = 51/289 (17%)
Query: 173 RTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITY----NGH 228
+T T++ S + + ++G SGKTTLL LA K+ L G I Y G
Sbjct: 39 KTNTTLVNTFSMDLPSGSVMAVMGGSGSGKTTLLNVLASKISGGLTHNGSIRYVLEDTGS 98
Query: 229 RLNEFVPRKTS--------------AYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLL 274
NE P++ AY+ Q DV +T +ETL F+A DL
Sbjct: 99 EPNETEPKRAHLDGQDHPIQKHVIMAYLPQQDVLSPRLTCRETLKFAA---------DLK 149
Query: 275 SELARREKEAGIFPEAELDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRG 334
+ R K+ L+ + ++ LGL C DT+VGD +RG
Sbjct: 150 LNSSERTKK------------------------LMVEQLIEELGLKDCADTLVGDNSHRG 185
Query: 335 VSGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQ 394
+SGG+K+R++ G ++ +F+DE +TGLD+ + F ++K L+++ T +MS+ Q
Sbjct: 186 LSGGEKRRLSIGTQMISNPSIMFLDEPTTGLDAYSAFLVIKTLKKLAKEDGRTFIMSIHQ 245
Query: 395 PAPETFDLFDDIILISEGQVVYQGPREHIVEFFESCGFRCPERKGTADF 443
P + L D + ++S+G VVY ++ + +FES G+ P+ AD+
Sbjct: 246 PRSDILFLLDQVCILSKGNVVYCDKMDNTIPYFESIGYHVPQLVNPADY 294
>ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2
(Placenta-specific ATP-binding cassette transporter)
(Breast cancer resistance protein)
Length = 655
Score = 131 bits (330), Expect = 3e-30
Identities = 91/277 (32%), Positives = 141/277 (50%), Gaps = 37/277 (13%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGH-RL 230
K + IL N +GI+KP A+L GP GK++LL LA + D + GD+ NG R
Sbjct: 57 KPVEKEILSNINGIMKPGLNAIL-GPTGGGKSSLLDVLAARKDPS-GLSGDVLINGAPRP 114
Query: 231 NEFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEA 290
F + S Y+ Q+DV +G +TV+E L FSA + L + + EK I
Sbjct: 115 ANF--KCNSGYVVQDDVVMGTLTVRENLQFSAALR-------LATTMTNHEKNERI---- 161
Query: 291 ELDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIV 350
+ ++ LGLD D+ VG + RGVSGG++KR + G ++
Sbjct: 162 --------------------NRVIEELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELI 201
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
LF+DE +TGLDSST ++ L+++ TI+ S+ QP F LFD + L++
Sbjct: 202 TDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR-TIIFSIHQPRYSIFKLFDSLTLLA 260
Query: 411 EGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
G++++ GP + + +FES G+ C ADF ++
Sbjct: 261 SGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDI 297
>ADP1_YEAST (P25371) Probable ATP-dependent permease precursor
Length = 1049
Score = 130 bits (327), Expect = 7e-30
Identities = 89/271 (32%), Positives = 140/271 (50%), Gaps = 32/271 (11%)
Query: 177 TILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPR 236
T+L SGIVKP ++ ++G +GKTTLL LA K + V G I NG ++
Sbjct: 404 TVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTG-HVSGSIKVNGISMDRKSFS 462
Query: 237 KTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFM 296
K ++ Q+D + +TV ET+ L S L R K EA+
Sbjct: 463 KIIGFVDQDDFLLPTLTVFETV--------------LNSALLRLPKALSF--EAK----- 501
Query: 297 KATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTL 356
KA K E I D KD I+G+E +RG+SGG+K+RV+ +V L
Sbjct: 502 KARVYKVLEELRIIDI----------KDRIIGNEFDRGISGGEKRRVSIACELVTSPLVL 551
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVY 416
F+DE ++GLD+S +++CL ++ T+++S+ QP F LFD ++L+S+G++VY
Sbjct: 552 FLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVY 611
Query: 417 QGPREHIVEFFESCGFRCPERKGTADFLQEV 447
G + + EF + G+ CP+ AD+L ++
Sbjct: 612 SGNAKKVSEFLRNEGYICPDNYNIADYLIDI 642
>PDRC_YEAST (Q02785) ATP-dependent permease PDR12
Length = 1511
Score = 124 bits (312), Expect = 4e-28
Identities = 95/350 (27%), Positives = 163/350 (46%), Gaps = 39/350 (11%)
Query: 106 DNEKYLRKFRNRIDKVGIRLPTVEVRFKNLT---VEADSFVGSRALPTLPNTALNILESL 162
D L R+R + GI + FKNLT V+A + G N A +I L
Sbjct: 90 DLRSLLHYLRSRQLEQGIEPGDSGIAFKNLTAVGVDASAAYGPSVEEMFRNIA-SIPAHL 148
Query: 163 IGLFGFNTTKRTKL---TILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRV 219
I F TK++ + I++N +G+V+ M ++G P +G +T L L+G+ + V
Sbjct: 149 ISKF----TKKSDVPLRNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSGETSELVDV 204
Query: 220 QGDITYNGHRLNEFVPRKTS--AYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSEL 277
QG+ +Y+G +E + + Y + D H ++TVKET+DF+ +C+ R D
Sbjct: 205 QGEFSYDGLDQSEMMSKYKGYVIYCPELDFHFPKITVKETIDFALKCKTPRVRID----- 259
Query: 278 ARREKEAGIFPEAELDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSG 337
K T + ++ I D + GL T VG++ RGVSG
Sbjct: 260 -------------------KMTRKQYVDN--IRDMWCTVFGLRHTYATKVGNDFVRGVSG 298
Query: 338 GQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAP 397
G++KRV+ E D + GLD+ST + + ++ ++ + ++++ Q
Sbjct: 299 GERKRVSLVEAQAMNASIYSWDNATRGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGE 358
Query: 398 ETFDLFDDIILISEGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
++LFD ++ G+ +Y GP + V +F+ G+ P R +A+FL V
Sbjct: 359 NIYELFDKTTVLYNGRQIYFGPADKAVGYFQRMGWVKPNRMTSAEFLTSV 408
Score = 95.5 bits (236), Expect = 2e-19
Identities = 72/274 (26%), Positives = 142/274 (51%), Gaps = 42/274 (15%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
+L + G VKP +M L+G +GKTTLL LA +++ + + GD+ N L R
Sbjct: 860 LLSDVFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGV-ITGDMLVNAKPLPASFNR- 917
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
+ Y++Q D H+ E++V+E+L F+A + +
Sbjct: 918 SCGYVAQADNHMAELSVRESLRFAAELR-------------------------------Q 946
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGPTKTL 356
++V E + + +LG+ + +VG + RG++ Q+K+++ G E++ P+ L
Sbjct: 947 QSSVPLEEKYEYVEKIITLLGMQNYAEALVG-KTGRGLNVEQRKKLSIGVELVAKPSLLL 1005
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE-GQVV 415
F+DE ++GLDS + + IV+ ++ + + +IL ++ QP+ F+ FD ++L+ + G++V
Sbjct: 1006 FLDEPTSGLDSQSAWSIVQFMRALADSGQ-SILCTIHQPSATLFEQFDRLLLLKKGGKMV 1064
Query: 416 YQGP----REHIVEFFE-SCGFRCPERKGTADFL 444
Y G E ++++FE G +C + A+++
Sbjct: 1065 YFGDIGPNSETLLKYFERQSGMKCGVSENPAEYI 1098
>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
Length = 1511
Score = 124 bits (312), Expect = 4e-28
Identities = 88/302 (29%), Positives = 149/302 (49%), Gaps = 32/302 (10%)
Query: 150 TLPNTALNILESLIGLFGFNTTKRTK-LTILKNASGIVKPSRMALLLGPPSSGKTTLLLA 208
T+ N IL+S GL F +K T ILK G + P + ++LG P SG TTLL +
Sbjct: 148 TVVNIPYKILKS--GLRKFQRSKETNTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKS 205
Query: 209 LAGKLDS-ELRVQGDITYNGHRLNEFVP--RKTSAYISQNDVHVGEMTVKETLDFSARCQ 265
++ +L I+Y+G+ ++ R Y ++ DVH+ +TV ETL AR +
Sbjct: 206 ISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADVHLPHLTVFETLVTVARLK 265
Query: 266 GVGTRYDLLSELARREKEAGIFPEAELDLFMKATAVKGTESSLITDYTLKILGLDICKDT 325
R + RE A E + + GL ++T
Sbjct: 266 TPQNRIKGVD----RESYANHLAEVAMATY----------------------GLSHTRNT 299
Query: 326 IVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTE 385
VG+++ RGVSGG++KRV+ E+ + +K D + GLDS+T + ++ L+ ++
Sbjct: 300 KVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISN 359
Query: 386 GTILMSLLQPAPETFDLFDDIILISEGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQ 445
+ +++ Q + + +DLF+ + ++ +G +Y GP + ++FE G+ CP R+ TADFL
Sbjct: 360 TSATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLT 419
Query: 446 EV 447
V
Sbjct: 420 SV 421
Score = 96.7 bits (239), Expect = 1e-19
Identities = 81/277 (29%), Positives = 134/277 (48%), Gaps = 42/277 (15%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
IL N G VKP + L+G +GKTTLL LA ++ + + GDI NG ++ PR
Sbjct: 887 ILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGV-ITGDILVNGIPRDKSFPRS 945
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
Y Q D+H+ TV+E+L FSA R+ E I
Sbjct: 946 IG-YCQQQDLHLKTATVRESLRFSA--------------YLRQPAEVSI----------- 979
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGPTKTL 356
E + + +KIL ++ D +VG G++ Q+KR+T G E+ P +
Sbjct: 980 ------EEKNRYVEEVIKILEMEKYADAVVG-VAGEGLNVEQRKRLTIGVELTAKPKLLV 1032
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE-GQVV 415
F+DE ++GLDS T + I + ++++ + + IL ++ QP+ FD ++ + G+ V
Sbjct: 1033 FLDEPTSGLDSQTAWSICQLMKKLANHGQ-AILCTIHQPSAILMQEFDRLLFMQRGGKTV 1091
Query: 416 YQGPR----EHIVEFFESCG-FRCPERKGTADFLQEV 447
Y G + ++++FES G +CP A+++ EV
Sbjct: 1092 YFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEV 1128
>PDRA_YEAST (P51533) ATP-dependent permease PDR10
Length = 1564
Score = 124 bits (310), Expect = 6e-28
Identities = 80/274 (29%), Positives = 139/274 (50%), Gaps = 31/274 (11%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGD--ITYNGHRLNEFVP 235
ILK G + P + ++LG P +G TTLL +++ ++ D ITYNG E
Sbjct: 195 ILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHG-FKISPDTIITYNGFSNKEIKN 253
Query: 236 --RKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELD 293
R Y +++D+H+ +TV +TL AR + R + G+ + D
Sbjct: 254 HYRGEVVYNAESDIHIPHLTVFQTLYTVARLK------------TPRNRIKGV----DRD 297
Query: 294 LFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPT 353
F K +T+ + GL DT VG++ RGVSGG++KRV+ E+ + +
Sbjct: 298 TFAKH----------MTEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGS 347
Query: 354 KTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQ 413
K D + GLDS+T + +K L+ +T+ +++ Q + + +DLFD + ++ +G
Sbjct: 348 KFQCWDNATRGLDSATALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGY 407
Query: 414 VVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
++ GP + ++F+ G+ CPER+ TAD+L +
Sbjct: 408 QIFFGPSKQAKKYFQRMGYVCPERQTTADYLTSI 441
Score = 95.1 bits (235), Expect = 3e-19
Identities = 79/283 (27%), Positives = 132/283 (45%), Gaps = 42/283 (14%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLN 231
K K IL N G VKP + L+G +GKTTLL LA + L + GD+ +G +
Sbjct: 935 KNGKRRILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGL-ITGDVFVDGRPRD 993
Query: 232 EFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE 291
+ PR + Y Q D+H+ TV+E+L FSA
Sbjct: 994 QSFPR-SIGYCQQQDLHLKTATVRESLRFSA----------------------------- 1023
Query: 292 LDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIV 350
+A V E + +++L + + D IVG G++ Q+KR+T G E+
Sbjct: 1024 --YLRQADDVSIEEKDKYVEEVIEVLEMKLYADAIVG-VPGEGLNVEQRKRLTIGVELAA 1080
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
P +F+DE ++GLDS T + + ++++ + IL ++ QP+ FD ++ +
Sbjct: 1081 KPKLLVFLDEPTSGLDSQTAWSTCQLMKKLASRGQ-AILCTIHQPSALLMQEFDRLLFLQ 1139
Query: 411 E-GQVVYQGPR----EHIVEFFESCG-FRCPERKGTADFLQEV 447
E GQ VY G + ++ +FE+ G +CP A+++ E+
Sbjct: 1140 EGGQTVYFGELGKGCKTMINYFEAHGAHKCPPDANPAEWMLEI 1182
>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
(Pleomorphic drug resistance homolog)
Length = 1542
Score = 123 bits (308), Expect = 1e-27
Identities = 79/277 (28%), Positives = 137/277 (48%), Gaps = 37/277 (13%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDS-ELRVQGDITYNGHRLNEFVP- 235
ILK G++KP + ++LG P SG TTLL +++ ++ I+YNG NE
Sbjct: 174 ILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISSTTHGFQISKDSVISYNGLTPNEIKKH 233
Query: 236 -RKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDL 294
R Y ++ D+H+ +TV +TL AR + R
Sbjct: 234 YRGEVVYNAEADIHLPHLTVYQTLVTVARLKTPQNR------------------------ 269
Query: 295 FMKATAVKGTE----SSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIV 350
VKG ++ +TD + GL +DT VG+++ RGVSGG++KRV+ E+ +
Sbjct: 270 ------VKGVTREDFANHVTDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVWI 323
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
+K D + GLDS+T + V+ L+ H+ + +++ Q + + ++LF+ + ++
Sbjct: 324 CGSKFQCWDNATRGLDSATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLFNKVSVLY 383
Query: 411 EGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
EG +Y G +H +F+ G+ CP+R+ DFL +
Sbjct: 384 EGYQIYFGDAQHAKVYFQKMGYFCPKRQTIPDFLTSI 420
Score = 92.4 bits (228), Expect = 2e-18
Identities = 79/282 (28%), Positives = 133/282 (47%), Gaps = 52/282 (18%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
IL N G VKP + L+G +GKTTLL LA + + + GD+ NG PR
Sbjct: 903 ILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERTTMGV-ITGDVMVNGR------PRD 955
Query: 238 TS-----AYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAEL 292
TS Y Q D+H+ TV+E+L FSA +
Sbjct: 956 TSFSRSIGYCQQQDLHLKTATVRESLRFSAYLR--------------------------- 988
Query: 293 DLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVG 351
+ ++V E + + +KIL ++ D +VG G++ Q+KR+T G E+
Sbjct: 989 ----QPSSVSIEEKNEYVEAVIKILEMETYADAVVGVP-GEGLNVEQRKRLTIGVELAAK 1043
Query: 352 PTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE 411
P +F+DE ++GLDS T + + ++++ + + IL ++ QP+ FD ++ + +
Sbjct: 1044 PKLLVFLDEPTSGLDSQTAWATCQLMKKLANHGQ-AILCTIHQPSAMLMQEFDRLLFLQK 1102
Query: 412 -GQVVYQGPR----EHIVEFFESCG-FRCPERKGTADFLQEV 447
GQ VY G + ++++FE G +CP A+++ EV
Sbjct: 1103 GGQTVYFGDLGKGCKTMIKYFEDHGAHKCPPDANPAEWMLEV 1144
>BFR1_SCHPO (P41820) Brefeldin A resistance protein
Length = 1530
Score = 122 bits (306), Expect = 2e-27
Identities = 113/452 (25%), Positives = 198/452 (43%), Gaps = 42/452 (9%)
Query: 2 DSNLSRSISRSLSRSSWKMEEVFASGRYSRRTSQVDEDEEALKWAAIEKLP-TYDRLRTS 60
D+ +++ +L+ ++ +S + +S VDE ++ ++ EK T + R+
Sbjct: 6 DTTHGQALGSTLNHTTEVTRISNSSDHFEDSSSNVDESLDSSNPSSNEKASHTNEEYRSK 65
Query: 61 IMQTFTEGDQPQPGNRQQHKEVDVTKLDMNERQQIIDKIFKVAEEDNEK-YLRKFRNRID 119
Q++ +P + + D + D + ++ F++ E N K YLR +++ +
Sbjct: 66 GNQSYVPSSSNEP-SPESSSNSDSSSSDDSSVDRLAGDPFELGENFNLKHYLRAYKDSLQ 124
Query: 120 KVGIRLPTVEVRFKNLTVEADSFVGSRALPTLPNTALNILESLIGLFGFNTTKRT-KLTI 178
+ I + V ++ +V G L T P+ L ++ T K+ + I
Sbjct: 125 RDDIITRSSGVCMRDHSVYGVGS-GYEFLKTFPDIFLQPYRAI-------TEKQVVEKAI 176
Query: 179 LKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNG---HRLNEFVP 235
L + + + ++LG P SG +T L ++ RV+G Y+G + +F P
Sbjct: 177 LSHCHALANAGELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKKFFP 236
Query: 236 RKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLF 295
Y +NDVH +T ETLDF+A+C+ R L R+E + E L
Sbjct: 237 GDL-LYSGENDVHFPSLTTAETLDFAAKCRTPNNR---PCNLTRQE-----YVSRERHLI 287
Query: 296 MKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKT 355
A GL +T VG++ RGVSGG++KRVT E
Sbjct: 288 ATA------------------FGLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTI 329
Query: 356 LFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVV 415
D + GLDSST F+ V L+ + + T ++ Q + + + LFD I ++ G+ +
Sbjct: 330 ACWDNSTRGLDSSTAFEFVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQI 389
Query: 416 YQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
Y GP + ++F GF C R+ T DFL +
Sbjct: 390 YYGPADKAKQYFLDMGFDCHPRETTPDFLTAI 421
Score = 112 bits (280), Expect = 2e-24
Identities = 85/277 (30%), Positives = 140/277 (49%), Gaps = 42/277 (15%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
+L G V P ++ L+G +GKTTLL LA ++D+ + V GD+ NG L+ R+
Sbjct: 900 LLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGV-VTGDMLVNGRGLDSTFQRR 958
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
T Y+ Q DVH+GE TV+E L FSA + +
Sbjct: 959 TG-YVQQQDVHIGESTVREALRFSAALR-------------------------------Q 986
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGPTKTL 356
+V +E + +K+L ++ + I+G G++ Q+KR T G E+ P L
Sbjct: 987 PASVPLSEKYEYVESVIKLLEMESYAEAIIGTP-GSGLNVEQRKRATIGVELAAKPALLL 1045
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE-GQVV 415
F+DE ++GLDS + + IV L+++ + IL ++ QP+ FD FD ++L+ + G+ V
Sbjct: 1046 FLDEPTSGLDSQSAWSIVCFLRKLADAGQ-AILCTIHQPSAVLFDQFDRLLLLQKGGKTV 1104
Query: 416 YQGP-REH---IVEFFESCG-FRCPERKGTADFLQEV 447
Y G EH ++ +FES G CP+ A+++ +V
Sbjct: 1105 YFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDV 1141
>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
Length = 1529
Score = 121 bits (303), Expect = 4e-27
Identities = 87/323 (26%), Positives = 157/323 (47%), Gaps = 39/323 (12%)
Query: 132 FKNLTVEADSFVGSRALPTLPNTALNILESLIGLFGFNTTKRTK----LTILKNASGIVK 187
+KNL+ DS A + +T NI+ L+ G K +K ILK G +
Sbjct: 141 WKNLSASGDS-----ADVSYQSTFANIVPKLLTK-GLRLLKPSKEEDTFQILKPMDGCLN 194
Query: 188 PSRMALLLGPPSSGKTTLLLALAGKLDS-ELRVQGDITYNGHRLNEFVP--RKTSAYISQ 244
P + ++LG P SG TTLL +++ ++ ++YNG ++ R Y ++
Sbjct: 195 PGELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSSDIRKHYRGEVVYNAE 254
Query: 245 NDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMKATAVKGT 304
+D+H+ +TV +TL AR + R G+ EA
Sbjct: 255 SDIHLPHLTVYQTLFTVARMKTPQNRIK------------GVDREAY------------- 289
Query: 305 ESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFMDEISTG 364
++ +T+ + GL +DT VG+++ RGVSGG++KRV+ E+ + + D + G
Sbjct: 290 -ANHVTEVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRG 348
Query: 365 LDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQGPREHIV 424
LDS+T + ++ L+ + + +++ Q + + +DLFD + ++ +G +Y GP +
Sbjct: 349 LDSATALEFIRALKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAK 408
Query: 425 EFFESCGFRCPERKGTADFLQEV 447
++F+ G+ CP R+ TADFL +
Sbjct: 409 KYFQDMGYYCPPRQTTADFLTSI 431
Score = 95.5 bits (236), Expect = 2e-19
Identities = 80/278 (28%), Positives = 134/278 (47%), Gaps = 44/278 (15%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
IL N G VKP + L+G +GKTTLL LA ++ + + G+I +G +E PR
Sbjct: 902 ILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGV-ITGNIFVDGRLRDESFPRS 960
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
Y Q D+H+ TV+E+L FSA + +
Sbjct: 961 IG-YCQQQDLHLKTATVRESLRFSAYLR-------------------------------Q 988
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGPTKTL 356
++V E + + +KIL + D +VG G++ Q+KR+T G E+ P +
Sbjct: 989 PSSVSIEEKNRYVEEVIKILEMQQYSDAVVG-VAGEGLNVEQRKRLTIGVELAARPKLLV 1047
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEG-TILMSLLQPAPETFDLFDDIILISE-GQV 414
F+DE ++GLDS T + + ++++ T G IL ++ QP+ FD ++ + + GQ
Sbjct: 1048 FLDEPTSGLDSQTAWDTCQLMRKLA--THGQAILCTIHQPSAILMQQFDRLLFLQKGGQT 1105
Query: 415 VYQGPR----EHIVEFFESCG-FRCPERKGTADFLQEV 447
VY G + ++++FES G +CP A+++ EV
Sbjct: 1106 VYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWMLEV 1143
>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
Length = 1499
Score = 121 bits (303), Expect = 4e-27
Identities = 77/271 (28%), Positives = 138/271 (50%), Gaps = 31/271 (11%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALA-GKLDSELRVQGDITYNG---HRLNEF 233
ILK+ I++P + ++LG P +G +TLL +A + + ITY+G H +
Sbjct: 167 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 226
Query: 234 VPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELD 293
R Y ++ DVH ++V +TL+F+AR + R + +
Sbjct: 227 Y-RGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGID------------------ 267
Query: 294 LFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPT 353
+ T K S + Y GL ++T VG++ RGVSGG++KRV+ E +
Sbjct: 268 ---RETYAKHMASVYMATY-----GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGA 319
Query: 354 KTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQ 413
D + GLDS+T + ++ L+ + + T L+++ Q + + ++LFD+++++ EG
Sbjct: 320 NIQCWDNATRGLDSATALEFIRALKTSATILDTTPLIAIYQCSQDAYELFDNVVVLYEGY 379
Query: 414 VVYQGPREHIVEFFESCGFRCPERKGTADFL 444
++ G E+FE+ G++CP+R+ TADFL
Sbjct: 380 QIFFGKASKAKEYFENMGWKCPQRQTTADFL 410
Score = 100 bits (250), Expect = 6e-21
Identities = 77/283 (27%), Positives = 139/283 (48%), Gaps = 41/283 (14%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLN 231
K+ IL + G VKP ++ L+G +GKTTLL L+ ++ + + G+ NGH L+
Sbjct: 869 KKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALD 928
Query: 232 EFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE 291
R + Y+ Q DVH+ TV+E L FSA + ++++++EK+ +
Sbjct: 929 SSFQR-SIGYVQQQDVHLETTTVREALQFSAYLR-------QSNKISKKEKDDYV----- 975
Query: 292 LDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIV 350
DY + +L + D +VG G++ Q+KR+T G E++
Sbjct: 976 -------------------DYVIDLLEMTDYADALVG-VAGEGLNVEQRKRLTIGVELVA 1015
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
P LF+DE ++GLDS T + I K ++++ + IL ++ QP+ FD ++ +
Sbjct: 1016 KPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDKLLFLQ 1074
Query: 411 E-GQVVYQGPR----EHIVEFFESCGF-RCPERKGTADFLQEV 447
+ G+ Y G + ++ +FE G CP+ A+++ +V
Sbjct: 1075 KGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQV 1117
>SNQ2_YEAST (P32568) SNQ2 protein
Length = 1501
Score = 120 bits (302), Expect = 5e-27
Identities = 89/322 (27%), Positives = 153/322 (46%), Gaps = 31/322 (9%)
Query: 128 VEVRFKNLTVEADSFVGSRALPTLPNTALNILESLIGLF-GFNTTKRTKLT-ILKNASGI 185
+ +R +T+E S G A T NIL + +F G + K+ I+ N + +
Sbjct: 123 IHIRKAGVTIEDVSAKGVDASALEGATFGNILCLPLTIFKGIKAKRHQKMRQIISNVNAL 182
Query: 186 VKPSRMALLLGPPSSGKTTLLLALAGKLDSELR-VQGDITYNGHRLNEFVPRKTS--AYI 242
+ M L+LG P +G ++ L AG++D V G++ Y+G E + R + Y
Sbjct: 183 AEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVAYDGIPQEEMMKRYKADVIYN 242
Query: 243 SQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMKATAVK 302
+ DVH +TVK+TLDF+ C+ R + +S+ KE + + DL+
Sbjct: 243 GELDVHFPYLTVKQTLDFAIACKTPALRVNNVSK-----KE---YIASRRDLYAT----- 289
Query: 303 GTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFMDEIS 362
I GL +T VG++ RGVSGG++KRV+ E + D +
Sbjct: 290 -------------IFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNAT 336
Query: 363 TGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQGPREH 422
GLD+ST + K ++ + +L + T +++ Q + ++ FD + ++ G+ +Y G
Sbjct: 337 RGLDASTALEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHE 396
Query: 423 IVEFFESCGFRCPERKGTADFL 444
+F G+ CP R+ TA+FL
Sbjct: 397 AKPYFAKMGYLCPPRQATAEFL 418
Score = 106 bits (265), Expect = 1e-22
Identities = 84/280 (30%), Positives = 147/280 (52%), Gaps = 45/280 (16%)
Query: 175 KLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFV 234
K +L N SG P M L+G +GKTTLL LA + + + GD+ NG ++
Sbjct: 868 KRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQR--NVGIITGDMLVNGRPIDASF 925
Query: 235 PRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE-LD 293
R+T Y+ Q D+H+ E+TV+E+L FSAR RR + P++E +D
Sbjct: 926 ERRTG-YVQQQDIHIAELTVRESLQFSAR--------------MRRPQH---LPDSEKMD 967
Query: 294 LFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGP 352
K +++LG++ + +VG E+ G++ Q+K+++ G E++ P
Sbjct: 968 YVEK---------------IIRVLGMEEYAEALVG-EVGCGLNVEQRKKLSIGVELVAKP 1011
Query: 353 TKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE- 411
LF+DE ++GLDS +++ I++ L+++ + +IL ++ QP+ F+ FD ++L+ +
Sbjct: 1012 DLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQ-SILCTIHQPSATLFEEFDRLLLLRKG 1070
Query: 412 GQVVYQGP----REHIVEFFESCGFR-CPERKGTADFLQE 446
GQ VY G I+ +FE G R C + A+++ E
Sbjct: 1071 GQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILE 1110
>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
Length = 1501
Score = 120 bits (302), Expect = 5e-27
Identities = 78/271 (28%), Positives = 136/271 (49%), Gaps = 31/271 (11%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALA-GKLDSELRVQGDITYNG---HRLNEF 233
ILK+ I++P + ++LG P +G +TLL +A + + ITY+G H +
Sbjct: 169 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 228
Query: 234 VPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELD 293
R Y ++ DVH ++V +TL+F+AR + R + +
Sbjct: 229 Y-RGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGID------------------ 269
Query: 294 LFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPT 353
+ T K S + Y GL ++T VG++ RGVSGG++KRV+ E +
Sbjct: 270 ---RETYAKHMASVYMATY-----GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGA 321
Query: 354 KTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQ 413
D + GLDS+T + ++ L+ + + T L+++ Q + + +DLFD ++++ EG
Sbjct: 322 NIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGY 381
Query: 414 VVYQGPREHIVEFFESCGFRCPERKGTADFL 444
++ G E+FE G++CP+R+ TADFL
Sbjct: 382 QIFFGKATKAKEYFEKMGWKCPQRQTTADFL 412
Score = 100 bits (249), Expect = 8e-21
Identities = 77/283 (27%), Positives = 139/283 (48%), Gaps = 41/283 (14%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLN 231
K+ IL + G VKP ++ L+G +GKTTLL L+ ++ + + G+ NGH L+
Sbjct: 871 KKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALD 930
Query: 232 EFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE 291
R + Y+ Q DVH+ TV+E L FSA + ++++++EK+ +
Sbjct: 931 SSFQR-SIGYVQQQDVHLPTSTVREALQFSAYLR-------QSNKISKKEKDDYV----- 977
Query: 292 LDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIV 350
DY + +L + D +VG G++ Q+KR+T G E++
Sbjct: 978 -------------------DYVIDLLEMTDYADALVG-VAGEGLNVEQRKRLTIGVELVA 1017
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
P LF+DE ++GLDS T + I K ++++ + IL ++ QP+ FD ++ +
Sbjct: 1018 KPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDRLLFLQ 1076
Query: 411 E-GQVVYQGPR----EHIVEFFESCGF-RCPERKGTADFLQEV 447
+ G+ Y G + ++ +FE G CP+ A+++ +V
Sbjct: 1077 KGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQV 1119
>ABG5_MOUSE (Q99PE8) ATP-binding cassette, sub-family G, member 5
(Sterolin-1)
Length = 652
Score = 120 bits (302), Expect = 5e-27
Identities = 78/270 (28%), Positives = 133/270 (48%), Gaps = 33/270 (12%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
ILK+ S ++ ++ +LG SGKTTLL A++G+L ++G++ NG L +
Sbjct: 69 ILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQD 128
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
+Y+ Q+DV + +TV+ETL RY + L R + D + K
Sbjct: 129 CFSYVLQSDVFLSSLTVRETL-----------RYTAMLALCR----------SSADFYNK 167
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLF 357
TE L L D ++G G+S G+++RV+ ++ K +
Sbjct: 168 KVEAVMTE-----------LSLSHVADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMM 216
Query: 358 MDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQ 417
+DE +TGLD T QIV L ++ + +++++ QP E F FD I +++ G++V+
Sbjct: 217 LDEPTTGLDCMTANQIVLLLAELAR-RDRIVIVTIHQPRSELFQHFDKIAILTYGELVFC 275
Query: 418 GPREHIVEFFESCGFRCPERKGTADFLQEV 447
G E ++ FF +CG+ CPE DF ++
Sbjct: 276 GTPEEMLGFFNNCGYPCPEHSNPFDFYMDL 305
>CDR4_CANAL (O74676) ABC transporter CDR4
Length = 1490
Score = 120 bits (300), Expect = 9e-27
Identities = 85/324 (26%), Positives = 151/324 (46%), Gaps = 37/324 (11%)
Query: 127 TVEVRFKNLTVEADSFVGSRALPTLPNTALNILESLIGLFGFNTTKR---TKLTILKNAS 183
T+ V +KNL GS + +T +N++ + LF R ILK
Sbjct: 123 TIGVAYKNLRA-----YGSASDADYQSTLVNLIPKYLSLFFREYILRHTGPTFDILKPMD 177
Query: 184 GIVKPSRMALLLGPPSSGKTTLLLALAGKLDS-ELRVQGDITYNGHRLNEFVP--RKTSA 240
G++KP + ++LG P +G +T L +A + + I YN +E R
Sbjct: 178 GLIKPGELTVVLGRPGAGCSTFLKTIASQTYGYHIDKDSVIRYNSLTPHEIKKHYRGEVV 237
Query: 241 YISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMKATA 300
Y ++ + H ++TV +TL+F+A+ + R +S A A +
Sbjct: 238 YCAETENHFPQLTVGDTLEFAAKMRTPQNRPLGVSRDAYARHLAAV-------------- 283
Query: 301 VKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFMDE 360
+ + GL ++T VG++ RGVSGG++KRV+ E+ + D
Sbjct: 284 ------------VMAVYGLSHTRNTKVGNDFIRGVSGGERKRVSIAEITLNNAMVQCWDN 331
Query: 361 ISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQGPR 420
+ GLDS+T + ++ L+ + T L+++ Q + + +DLFD ++L+ +G +Y G
Sbjct: 332 STRGLDSATALEFIRALKASADIVHTTPLVAIYQCSQDAYDLFDKVVLMYQGYQIYFGSA 391
Query: 421 EHIVEFFESCGFRCPERKGTADFL 444
+ ++F G+ CP+R+ TADFL
Sbjct: 392 KKAKQYFIDMGYECPQRQTTADFL 415
Score = 100 bits (249), Expect = 8e-21
Identities = 78/277 (28%), Positives = 136/277 (48%), Gaps = 41/277 (14%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
IL + SG VKP ++ L+G +GKTTLL AL+ +L + + +G NG L+ R
Sbjct: 864 ILDHVSGWVKPGQVTALMGASGAGKTTLLNALSDRLTTGVVTEGIRLVNGRPLDSSFQRS 923
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
Y+ Q D+H+ TV+E L+F+A + ++R+EK +
Sbjct: 924 IG-YVQQQDLHLETSTVREALEFAAYLRQP-------KSVSRKEKNEYV----------- 964
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIVGPTKTL 356
DY +++L ++ D +VG G++ Q+KR++ G E++ P +
Sbjct: 965 -------------DYIIRLLEMEQYADAVVGVS-GEGLNVEQRKRLSIGVELVAKPKLLV 1010
Query: 357 FMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISE-GQVV 415
F+DE ++GLDS T + I K ++++ + IL ++ QP+ FD ++ + GQ V
Sbjct: 1011 FLDEPTSGLDSQTAWSICKLIRKLADNGQ-AILCTIHQPSAILLAEFDRLLFLQRGGQTV 1069
Query: 416 YQGPR----EHIVEFFESCGF-RCPERKGTADFLQEV 447
Y G ++ +FE G +CP A+++ EV
Sbjct: 1070 YFGDLGKNFTTLINYFEKYGAPKCPPEANPAEWMLEV 1106
>ABG5_HUMAN (Q9H222) ATP-binding cassette, sub-family G, member 5
(Sterolin-1)
Length = 651
Score = 118 bits (295), Expect = 4e-26
Identities = 79/270 (29%), Positives = 131/270 (48%), Gaps = 33/270 (12%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
ILK+ S V+ ++ +LG SGKTTLL A++G+L G++ NG L +
Sbjct: 68 ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD 127
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
+Y+ Q+D + +TV+ETL ++A LA R G F + K
Sbjct: 128 CFSYVLQSDTLLSSLTVRETLHYTAL-------------LAIRRGNPGSFQK-------K 167
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLF 357
AV + L L D ++G+ G+S G+++RV+ ++ K +
Sbjct: 168 VEAV------------MAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVML 215
Query: 358 MDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQ 417
DE +TGLD T QIV L ++ +++++ QP E F LFD I ++S G++++
Sbjct: 216 FDEPTTGLDCMTANQIVVLLVELARRNR-IVVLTIHQPRSELFQLFDKIAILSFGELIFC 274
Query: 418 GPREHIVEFFESCGFRCPERKGTADFLQEV 447
G +++FF CG+ CPE DF ++
Sbjct: 275 GTPAEMLDFFNDCGYPCPEHSNPFDFYMDL 304
>ABG5_RAT (Q99PE7) ATP-binding cassette, sub-family G, member 5
(Sterolin-1)
Length = 652
Score = 117 bits (293), Expect = 6e-26
Identities = 78/270 (28%), Positives = 133/270 (48%), Gaps = 33/270 (12%)
Query: 178 ILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRK 237
ILK+ S ++ + +LG SGKTTLL A++G+L ++G++ NG L +
Sbjct: 69 ILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQD 128
Query: 238 TSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMK 297
+Y+ Q+DV + +TV+ETL ++A LA R A + + K
Sbjct: 129 CVSYLLQSDVFLSSLTVRETLRYTAM-------------LALRSSSADFYDK-------K 168
Query: 298 ATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLF 357
AV L L L D ++G+ G+S G+++RV+ ++ K +
Sbjct: 169 VEAV------------LTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMM 216
Query: 358 MDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQ 417
+DE +TGLD T IV L ++ +++++ QP E F FD I +++ G++V+
Sbjct: 217 LDEPTTGLDCMTANHIVLLLVELARRNR-IVIVTIHQPRSELFHHFDKIAILTYGELVFC 275
Query: 418 GPREHIVEFFESCGFRCPERKGTADFLQEV 447
G E ++ FF +CG+ CPE DF ++
Sbjct: 276 GTPEEMLGFFNNCGYPCPEHSNPFDFYMDL 305
>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
Length = 1501
Score = 117 bits (292), Expect = 8e-26
Identities = 88/355 (24%), Positives = 163/355 (45%), Gaps = 44/355 (12%)
Query: 96 IDKIFKVAEEDNEKYLRKFRNRIDKVGIRLPTVEVRFKNLTVEADSFVGSRALPTLPNTA 155
+ ++K+ + D+E Y + K+G V +KNL V D+ + S T+ N
Sbjct: 93 VQNMWKLYQSDSEYY------KPGKLG-------VAYKNLRVYGDA-IESDYQTTVSNGV 138
Query: 156 LNILESLIGLFGFNTTKRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDS 215
L ++ F + + ILK G++KP + ++LG P +G +T L +A + +
Sbjct: 139 LKYARNIFNKFRKDNDDYS-FDILKPMEGLIKPGEVTVVLGRPGAGCSTFLKTIACRTEG 197
Query: 216 ELRVQGD-ITYNGHRLNEFVP--RKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYD 272
G I+Y+G +E R Y ++ + H +TV ETL+F+A +
Sbjct: 198 FHVADGSVISYDGITQDEIRNHLRGEVVYCAETETHFPNLTVGETLEFAALMK------- 250
Query: 273 LLSELARREKEAGIFPEAELDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMN 332
+ + G+ E + + D + GL K+T VG++
Sbjct: 251 -----TPQNRPMGVSRE--------------EYAKHVVDVVMATYGLSHTKNTKVGNDFI 291
Query: 333 RGVSGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSL 392
RG+SGG++KR++ E+ + D + GLD++T + + L+ + T L+++
Sbjct: 292 RGISGGERKRLSIAEVTLVQASIQCWDNSTRGLDAATALEFISSLKTSASILNDTPLIAI 351
Query: 393 LQPAPETFDLFDDIILISEGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
Q + +DLFD +I++ EG ++ G + +F+ GF C +R+ T DFL +
Sbjct: 352 YQCSQNAYDLFDKVIVMYEGYQIFFGSSQRAAAYFKKMGFVCQDRQTTPDFLTSI 406
Score = 103 bits (256), Expect = 1e-21
Identities = 82/279 (29%), Positives = 137/279 (48%), Gaps = 40/279 (14%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLN 231
K + IL N G VKP + L+G +GKTTLL AL+ +L + + G NG L+
Sbjct: 852 KSEERVILNNIDGWVKPGEVTALMGASGAGKTTLLNALSERLTTGVITSGTRMVNGGELD 911
Query: 232 EFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE 291
R Y+ Q D+H+ TV+E L FSAR + + ++ EK++ + E
Sbjct: 912 SSFQRSIG-YVQQQDLHLETSTVREALKFSARLRQPNS-------VSIAEKDS--YVEKI 961
Query: 292 LDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTG-EMIV 350
+DL T V D IVG G++ Q+KR+T E++
Sbjct: 962 IDLLEMRTYV----------------------DAIVGVP-GEGLNVEQRKRLTIAVELVA 998
Query: 351 GPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILIS 410
P +F+DE ++GLDS T + I K ++++ + + IL ++ QP+ + FD ++L+
Sbjct: 999 RPKLLVFLDEPTSGLDSQTAWSICKLIRKLANHGQ-AILCTIHQPSAILLEEFDRLLLLQ 1057
Query: 411 EGQVVYQGP----REHIVEFFESCG-FRCPERKGTADFL 444
+G+ VY G ++E+FE G +CP+ A+++
Sbjct: 1058 KGETVYFGEFGANCHTLIEYFERNGASKCPQHANPAEWM 1096
>ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 673
Score = 111 bits (277), Expect = 4e-24
Identities = 76/265 (28%), Positives = 129/265 (48%), Gaps = 32/265 (12%)
Query: 179 LKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRKT 238
++N S V+ +M ++G G+ +LL + G+ G I NG + + RK
Sbjct: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKC 147
Query: 239 SAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMKA 298
A++ Q++ + +TV+ETL F A+ + T S+ R ++ + E
Sbjct: 148 VAHVRQHNQLLPNLTVRETLAFIAQMRLPRT----FSQAQRDKRVEDVIAE--------- 194
Query: 299 TAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFM 358
L L C DT VG+ RG+SGG+++RV+ G ++ L +
Sbjct: 195 ------------------LRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILIL 236
Query: 359 DEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQG 418
DE ++GLDS T +VK L ++ +L+SL QP + F LFD ++L++ G +Y G
Sbjct: 237 DEPTSGLDSFTAHNLVKTLSRLAKGNR-LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 295
Query: 419 PREHIVEFFESCGFRCPERKGTADF 443
+H+V++F + G+ CP ADF
Sbjct: 296 AAQHMVQYFTAIGYPCPRYSNPADF 320
>ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4
Length = 646
Score = 108 bits (270), Expect = 3e-23
Identities = 83/278 (29%), Positives = 135/278 (47%), Gaps = 45/278 (16%)
Query: 172 KRTKLTILKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLN 231
KR T+LK SG + ++GP +GK+T + LAG +S ++ G I NG
Sbjct: 78 KRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMK--GQILVNGRPRE 135
Query: 232 EFVPRKTSAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAE 291
RK S YI Q+D+ + +TV E + SA + LSE +KE
Sbjct: 136 LRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLK--------LSEKQEVKKE-------- 179
Query: 292 LDLFMKATAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVG 351
L+T+ L LGL C T +SGGQ+KR+ +V
Sbjct: 180 ----------------LVTE-ILTALGLMSCSHT-----RTALLSGGQRKRLAIALELVN 217
Query: 352 PTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEG--TILMSLLQPAPETFDLFDDIILI 409
+F DE ++GLDS++ FQ+V ++ L +G TI+ ++ QP+ + F++FD + ++
Sbjct: 218 NPPVMFFDEPTSGLDSASCFQVVSLMKS---LAQGGRTIICTIHQPSAKLFEMFDKLYIL 274
Query: 410 SEGQVVYQGPREHIVEFFESCGFRCPERKGTADFLQEV 447
S+GQ +++G +++ + + G CP ADF+ EV
Sbjct: 275 SQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEV 312
>ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 673
Score = 107 bits (268), Expect = 5e-23
Identities = 76/265 (28%), Positives = 125/265 (46%), Gaps = 32/265 (12%)
Query: 179 LKNASGIVKPSRMALLLGPPSSGKTTLLLALAGKLDSELRVQGDITYNGHRLNEFVPRKT 238
++N S V+ +M ++G G+ +LL + G+ G I NG + RK
Sbjct: 89 IRNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQPSTPQLVRKC 148
Query: 239 SAYISQNDVHVGEMTVKETLDFSARCQGVGTRYDLLSELARREKEAGIFPEAELDLFMKA 298
A++ Q+D + +TV+ETL F A+ + T S+ R ++ + E
Sbjct: 149 VAHVRQHDQLLPNLTVRETLAFIAQMRLPRT----FSQAQRDKRVEDVIAE--------- 195
Query: 299 TAVKGTESSLITDYTLKILGLDICKDTIVGDEMNRGVSGGQKKRVTTGEMIVGPTKTLFM 358
L L C +T VG+ RGVSGG+++RV+ G ++ L +
Sbjct: 196 ------------------LRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILIL 237
Query: 359 DEISTGLDSSTTFQIVKCLQQIVHLTEGTILMSLLQPAPETFDLFDDIILISEGQVVYQG 418
DE ++GLDS T +V L ++ +L+SL QP + F LFD ++L++ G +Y G
Sbjct: 238 DEPTSGLDSFTAHNLVTTLSRLAKGNR-LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 296
Query: 419 PREHIVEFFESCGFRCPERKGTADF 443
+ +V++F S G CP ADF
Sbjct: 297 AAQQMVQYFTSIGHPCPRYSNPADF 321
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.317 0.135 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,671,846
Number of Sequences: 164201
Number of extensions: 2075224
Number of successful extensions: 10188
Number of sequences better than 10.0: 792
Number of HSP's better than 10.0 without gapping: 432
Number of HSP's successfully gapped in prelim test: 360
Number of HSP's that attempted gapping in prelim test: 8910
Number of HSP's gapped (non-prelim): 1472
length of query: 447
length of database: 59,974,054
effective HSP length: 113
effective length of query: 334
effective length of database: 41,419,341
effective search space: 13834059894
effective search space used: 13834059894
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Medicago: description of AC123976.3