BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC123593.7 + phase: 0 
         (467 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

NTPA_PEA (P52914) Nucleoside-triphosphatase (EC 3.6.1.15) (Nucle...   526  e-149
APY_SOLTU (P80595) Apyrase precursor (EC 3.6.1.5) (ATP-diphospha...   471  e-132
ENP6_HUMAN (O75354) Ectonucleoside triphosphate diphosphohydrola...   182  1e-45
GDA1_KLULA (Q9HEM6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    177  4e-44
ENP5_HUMAN (O75356) Ectonucleoside triphosphate diphosphohydrola...   176  9e-44
ENP6_RAT (Q9ER31) Ectonucleoside triphosphate diphosphohydrolase...   174  6e-43
ENP5_MOUSE (Q9WUZ9) Ectonucleoside triphosphate diphosphohydrola...   173  1e-42
ENP5_MESAU (Q9QYC8) Ectonucleoside triphosphate diphosphohydrola...   173  1e-42
GDA1_SCHPO (Q9UT35) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    172  1e-42
GDA1_ASPFU (Q8TGG8) Probable guanosine-diphosphatase (EC 3.6.1.4...   162  1e-39
GDA1_CANAL (Q8TGH6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    160  7e-39
GDA1_YEAST (P32621) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    151  4e-36
ENP1_MOUSE (P55772) Ectonucleoside triphosphate diphosphohydrola...   137  5e-32
ENP1_RAT (P97687) Ectonucleoside triphosphate diphosphohydrolase...   136  1e-31
ENP2_CHICK (P79784) Ectonucleoside triphosphate diphosphohydrola...   127  5e-29
MI23_CAEEL (Q21815) Nucleoside-diphosphatase mig-23 (EC 3.6.1.-)...   123  9e-28
YND1_YEAST (P40009) Golgi apyrase (EC 3.6.1.5) (ATP-diphosphatas...   119  2e-26
NTP1_CAEEL (Q18411) Putative nucleoside-triphosphatase ntp-1 (EC...   117  6e-26
ENP2_MOUSE (O55026) Ectonucleoside triphosphate diphosphohydrola...   112  2e-24
ENP2_HUMAN (Q9Y5L3) Ectonucleoside triphosphate diphosphohydrola...   110  6e-24

>NTPA_PEA (P52914) Nucleoside-triphosphatase (EC 3.6.1.15)
           (Nucleoside triphosphate phosphohydrolase) (NTPase)
           (Apyrase)
          Length = 455

 Score =  526 bits (1356), Expect = e-149
 Identities = 255/441 (57%), Positives = 343/441 (76%), Gaps = 4/441 (0%)

Query: 29  ILLITFVLYMMPSSSNYDSAGDYALLNRKLSPDKKSGGSYAVIFDAGSSGSRVHVFHFDQ 88
           I LITF+L+ MP+ ++    G+  L +RK+   ++   SYAV+FDAGS+GSR+HV+HF+Q
Sbjct: 5   IKLITFLLFSMPAITSSQYLGNNLLTSRKIFLKQEEISSYAVVFDAGSTGSRIHVYHFNQ 64

Query: 89  NLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLLEKAEGVVPRELRSKTPVRIGA 148
           NLDL+HIGK +E + ++ PGLS+YA  P+QAA+SL+ LLE+AE VVP +L+ KTPVR+GA
Sbjct: 65  NLDLLHIGKGVEYYNKITPGLSSYANNPEQAAKSLIPLLEQAEDVVPDDLQPKTPVRLGA 124

Query: 149 TAGLRALEGDASDKILRAVRDLLKHRSSFKSDADAVTVLDGTQEGAYQWVTINYLLGNLG 208
           TAGLR L GDAS+KIL++VRD+L +RS+F    DAV+++DGTQEG+Y WVT+NY LGNLG
Sbjct: 125 TAGLRLLNGDASEKILQSVRDMLSNRSTFNVQPDAVSIIDGTQEGSYLWVTVNYALGNLG 184

Query: 209 KDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYL 268
           K Y+KTVGV+DLGGGSVQMAYA+S+  A  AP+V DG+DPY+K++ L+G  Y LYVHSYL
Sbjct: 185 KKYTKTVGVIDLGGGSVQMAYAVSKKTAKNAPKVADGDDPYIKKVVLKGIPYDLYVHSYL 244

Query: 269 RYGLLAARAEILKVAGDAENPCILSGSDGTYKYGGKSFKAS--SSGASLNECKSVAHKAL 326
            +G  A+RAEILK+   + NPC+L+G +G Y Y G+ FKA+  +SGA+ N+CK+   KAL
Sbjct: 245 HFGREASRAEILKLTPRSPNPCLLAGFNGIYTYSGEEFKATAYTSGANFNKCKNTIRKAL 304

Query: 327 KVNESTCTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFE 386
           K+N   C +  CTFGGIWNGGGG+GQKNLF +S FF    + G VD ++P  I+RP D E
Sbjct: 305 KLN-YPCPYQNCTFGGIWNGGGGNGQKNLFASSSFFYLPEDTGMVDASTPNFILRPVDIE 363

Query: 387 DAAKQACQTKLENAKSTYPRVEEGNL-PYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVK 445
             AK+AC    E+AKSTYP +++ N+  Y+CMDL+YQY LLVDGFG+ P Q+IT  K+++
Sbjct: 364 TKAKEACALNFEDAKSTYPFLDKKNVASYVCMDLIYQYVLLVDGFGLDPLQKITSGKEIE 423

Query: 446 YDDALVEAAWPLGSAIEAVSS 466
           Y DA+VEAAWPLG+A+EA+S+
Sbjct: 424 YQDAIVEAAWPLGNAVEAISA 444


>APY_SOLTU (P80595) Apyrase precursor (EC 3.6.1.5)
           (ATP-diphosphatase) (Adenosine diphosphatase) (ADPase)
           (ATP-diphosphohydrolase)
          Length = 454

 Score =  471 bits (1211), Expect = e-132
 Identities = 238/441 (53%), Positives = 309/441 (69%), Gaps = 6/441 (1%)

Query: 29  ILLITFVLYMMPSSSNYDSAGDYALLNRKLSPDKKSGGSYAVIFDAGSSGSRVHVFHFDQ 88
           I +I  +  ++P S    +      L R L   +     YAVIFDAGS+GSRVHVF FD+
Sbjct: 9   IFIILAIFLVLPLSLLSKNVNAQIPLRRHLLSHESE--HYAVIFDAGSTGSRVHVFRFDE 66

Query: 89  NLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLLEKAEGVVPRELRSKTPVRIGA 148
            L L+ IG ++E F   +PGLS+YA+ P+ AA SL  LL+ AEGVVP+EL+S+TP+ +GA
Sbjct: 67  KLGLLPIGNNIEYFMATEPGLSSYAEDPKAAANSLEPLLDGAEGVVPQELQSETPLELGA 126

Query: 149 TAGLRALEGDASDKILRAVRDLLKHRSSFKSDADAVTVLDGTQEGAYQWVTINYLLGNLG 208
           TAGLR L+GDA++KIL+AVR+L+K++S+F S    VT+LDGTQEG+Y W  INYLLGNLG
Sbjct: 127 TAGLRMLKGDAAEKILQAVRNLVKNQSTFHSKDQWVTILDGTQEGSYMWAAINYLLGNLG 186

Query: 209 KDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYL 268
           KDY  T   +DLGGGSVQMAYAIS  + A APQ  DGE PYV++  L  + Y LYVHSYL
Sbjct: 187 KDYKSTTATIDLGGGSVQMAYAISNEQFAKAPQNEDGE-PYVQQKHLMSKDYNLYVHSYL 245

Query: 269 RYGLLAARAEILKVAGDAENPCILSGSDGTYKYGGKSF--KASSSGASLNECKSVAHKAL 326
            YG LA RAEI K + +  NPC L G DG Y YGG  +  KA   G+S   C+ +   AL
Sbjct: 246 NYGQLAGRAEIFKASRNESNPCALEGCDGYYSYGGVDYKVKAPKKGSSWKRCRRLTRHAL 305

Query: 327 KVNESTCTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFE 386
           K+N + C   +CTF G+WNGGGGDGQKN+  +SFF+D  A+ G VD   P A+ +P  + 
Sbjct: 306 KIN-AKCNIEECTFNGVWNGGGGDGQKNIHASSFFYDIGAQVGIVDTKFPSALAKPIQYL 364

Query: 387 DAAKQACQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKY 446
           +AAK ACQT + + KS +P+ ++ N+PYLCMDL+Y+YTLLVDGFG+ P +EIT++  V+Y
Sbjct: 365 NAAKVACQTNVADIKSIFPKTQDRNIPYLCMDLIYEYTLLVDGFGLNPHKEITVIHDVQY 424

Query: 447 DDALVEAAWPLGSAIEAVSST 467
            + LV AAWPLG AI+ VSST
Sbjct: 425 KNYLVGAAWPLGCAIDLVSST 445


>ENP6_HUMAN (O75354) Ectonucleoside triphosphate diphosphohydrolase
           6 (EC 3.6.1.6) (NTPDase6) (CD39 antigen-like 2)
          Length = 484

 Score =  182 bits (463), Expect = 1e-45
 Identities = 131/414 (31%), Positives = 209/414 (49%), Gaps = 55/414 (13%)

Query: 68  YAVIFDAGSSGSRVHVFHFD----QNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESL 123
           Y ++FDAGS+G+RVHVF F     +   L H     E F+ LKPGLSAYA   +++A+ +
Sbjct: 102 YGIMFDAGSTGTRVHVFQFTRPPRETPTLTH-----ETFKALKPGLSAYADDVEKSAQGI 156

Query: 124 VSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSDADA 183
             LL+ A+  +P +    TP+ + ATAGLR L G+ + K+L+ V+++ K  S F    D 
Sbjct: 157 RELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFK-ASPFLVGDDC 215

Query: 184 VTVLDGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVM 243
           V++++GT EG   W+TIN+L G+L      +VG++DLGGGS Q+A+         A    
Sbjct: 216 VSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQA---- 271

Query: 244 DGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEIL--------KVAGDAENPCILSGS 295
                Y+  + +  R Y LY +SYL  GL++AR  IL        K   +  +PC+    
Sbjct: 272 -SPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSF 330

Query: 296 DGTYKYGGKSFKAS--SSGASLNE-CKSVAHKALKVNESTCTHMKCTFGGIWNGGGGDGQ 352
            G +++   +++ S   + ASL+E C +   + L+        +K               
Sbjct: 331 KGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVK--------------H 376

Query: 353 KNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQTKLENAKSTYPRVEEGNL 412
            + +  S+++D AA  G +D     ++V   DFE AAK  C+T     +S+         
Sbjct: 377 VDFYAFSYYYDLAAGVGLIDAEKGGSLV-VGDFEIAAKYVCRTLETQPQSS--------- 426

Query: 413 PYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGSAIEAVSS 466
           P+ CMDL Y  +LL+  FG    + + L +K+      VE +W LG+    + S
Sbjct: 427 PFSCMDLTY-VSLLLQEFGFPRSKVLKLTRKIDN----VETSWALGAIFHYIDS 475


>GDA1_KLULA (Q9HEM6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 522

 Score =  177 bits (450), Expect = 4e-44
 Identities = 150/445 (33%), Positives = 216/445 (47%), Gaps = 70/445 (15%)

Query: 65  GGSYAVIFDAGSSGSRVHVFHFD---QNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAE 121
           G  Y V+ DAGS+GSRVHV+ FD   Q   L++     E FE LKPGLS++      AA+
Sbjct: 94  GHKYVVMIDAGSTGSRVHVYEFDVCTQPPTLIN-----ETFEMLKPGLSSFDIDAVGAAK 148

Query: 122 SLVSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFK-SD 180
           SL  LL+ A   VP++ R+ TPV + ATAGLR L  + S KIL  VR  L+    F   D
Sbjct: 149 SLDPLLKIAMDAVPKDKRNCTPVAVKATAGLRMLGDEKSSKILAQVRKHLEQDYPFPVVD 208

Query: 181 ADAVTVLDGTQEGAYQWVTINYLLGNLGKDYS-KTVGVVDLGGGSVQMAYAISESEAAMA 239
            D V+++DG +EG Y WVT NYLLGN+G      T  V DLGGGS Q+ +   E      
Sbjct: 209 GDGVSIMDGEEEGVYAWVTANYLLGNIGAGSKLPTAAVFDLGGGSTQIVF---EPSFPPN 265

Query: 240 PQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAAR----AEILKVA------------ 283
            +++DGE  Y  E+   G  Y LY  S+L YGL+  R     E++ VA            
Sbjct: 266 EKMVDGEHKY--ELSFGGHDYTLYQFSHLGYGLMQGRNKINTELVNVAISSGTITKGQTA 323

Query: 284 --GDAENPCILSGS-----------DGTYKYGGKSFKASSSGASLNECKSVAHKALKVNE 330
              +  +PC+  G+           D  Y    K  K  +      +C+ +A K L   +
Sbjct: 324 RTYELSSPCLPPGTTAEGEKVKISDDEIYTVNFKGPKVPAG----PQCRYLADKILN-KD 378

Query: 331 STCTHMKCTFGGIWNGGGGDGQK---NLFVASFFFDRAAEAGFVDPNSPVAIVRPADFED 387
           + C    C+F GI         K   +L+V S+F+DR    G      P++     + +D
Sbjct: 379 AKCNTPPCSFNGIHQPSLVHTFKETSDLYVFSYFYDRTQPLGL-----PLSFTL-QELQD 432

Query: 388 AAKQACQTKLENAKSTYPRVEEGNL------PYLCMDLVYQYTLLVDGFGIYPWQEITLV 441
            A+  C  + E  +S +  + EG+L      P  C+DL +Q +LL  G+ I   +E+   
Sbjct: 433 LARTVCNGE-EVWESVFSGI-EGSLSELSKEPQWCLDLNFQVSLLHTGYDIPLQRELRTA 490

Query: 442 KKVKYDDALVEAAWPLGSAIEAVSS 466
           K +    A  E  W LG+++  + S
Sbjct: 491 KTI----ANNELGWCLGASLPLLES 511


>ENP5_HUMAN (O75356) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
          Length = 428

 Score =  176 bits (447), Expect = 9e-44
 Identities = 127/408 (31%), Positives = 196/408 (47%), Gaps = 42/408 (10%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLL 127
           Y ++FDAGS+G+R+HV+ F Q +       + E+F+ +KPGLSA+  +P+Q AE++  LL
Sbjct: 49  YGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAETVQGLL 108

Query: 128 EKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSDADAVTVL 187
           E A+  +PR    KTPV + ATAGLR L    +  +L  V+++ + +S F     +V+++
Sbjct: 109 EVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFR-KSPFLVPKGSVSIM 167

Query: 188 DGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAIS-ESEAAMAPQVMDGE 246
           DG+ EG   WVT+N+L G L     +TVG +DLGG S Q+ +    E      P+     
Sbjct: 168 DGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPR----- 222

Query: 247 DPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEILKV-------AGDAENPCILSGSDGTY 299
             Y+    +    Y LY HSYL +GL AAR   L              + C+    +  +
Sbjct: 223 -GYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEW 281

Query: 300 KYGGKSFKASSSGASLNECKSVAHKALKVNESTCTHMKCTFGGIWNGGGGDGQKNLFVA- 358
            +GG  ++   +       +    + L+V        +            + Q+  F A 
Sbjct: 282 IFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPE------------EVQRGSFYAF 329

Query: 359 SFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQTKLENAKSTYPRVEEGNLPYLCMD 418
           S+++DRA +   +D      I++  DFE  A++ C   LEN  S          P+LCMD
Sbjct: 330 SYYYDRAVDTDMIDYEKG-GILKVEDFERKAREVCD-NLENFTS--------GSPFLCMD 379

Query: 419 LVYQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGSAIEAVSS 466
           L Y   LL DGFG      + L KKV      +E  W LG+    + S
Sbjct: 380 LSYITALLKDGFGFADSTVLQLTKKVNN----IETGWALGATFHLLQS 423


>ENP6_RAT (Q9ER31) Ectonucleoside triphosphate diphosphohydrolase 6
           (EC 3.6.1.6) (NTPDase6) (CD39 antigen-like 2)
          Length = 455

 Score =  174 bits (440), Expect = 6e-43
 Identities = 132/425 (31%), Positives = 210/425 (49%), Gaps = 57/425 (13%)

Query: 59  SPDKKSGGS---YAVIFDAGSSGSRVHVFHF----DQNLDLVHIGKDLELFEQLKPGLSA 111
           SPD  + G    Y ++FDAGS+G+R+HVF F     +   L H     E F+ LKPGLSA
Sbjct: 62  SPDSATRGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTLTH-----ETFKALKPGLSA 116

Query: 112 YAQKPQQAAESLVSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLL 171
           YA   +++A+ +  LL  A+  +P +    TP+ + ATAGLR L G+ + K+L+ V+++ 
Sbjct: 117 YADDVEKSAQGIQELLNVAKQHIPYDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVF 176

Query: 172 KHRSSFKSDADAVTVLDGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAI 231
           K  S F    D V++++GT EG   W+T+N+L G+L    S +VG++DLGGGS Q+ +  
Sbjct: 177 K-ASPFLVGDDCVSIMNGTDEGVSAWITVNFLTGSLKTPGSSSVGMLDLGGGSTQITFLP 235

Query: 232 SESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEIL-----KVAGDA 286
                  A         ++  + +  R + LY +SYL  GL++AR  IL     K A D 
Sbjct: 236 RVEGTLQA-----SPPGHLTALQMFNRTFKLYSYSYLGLGLMSARLAILGGVEGKPAEDD 290

Query: 287 E---NPCILSGSDGTYKYGGKSFKASSSGA-SLNE-CKSVAHKALKVNESTCTHMKCTFG 341
           +   +PC+     G +++   +++ S   A  L E C S   + L+         +    
Sbjct: 291 KELVSPCLSPRFRGKWEHAEVTYRISGQKAVGLYELCASRVSEVLRNKVHRTEEAQ---- 346

Query: 342 GIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQTKLENAK 401
                       + +  S+++D AA  G +D     ++V   DFE AAK  C+T      
Sbjct: 347 ----------HVDFYAFSYYYDLAASFGLIDAEKGGSLV-VGDFEIAAKYVCRTLETQPP 395

Query: 402 STYPRVEEGNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGSAI 461
           S+         P+ CMDL Y  +LL+  FG    + + L +K+      VE +W LG+  
Sbjct: 396 SS---------PFACMDLTY-ISLLLHEFGFPGDKVLKLARKIDN----VETSWALGAIF 441

Query: 462 EAVSS 466
             + S
Sbjct: 442 HYIDS 446


>ENP5_MOUSE (Q9WUZ9) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
          Length = 427

 Score =  173 bits (438), Expect = 1e-42
 Identities = 123/411 (29%), Positives = 195/411 (46%), Gaps = 40/411 (9%)

Query: 64  SGGSYAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESL 123
           +G  Y ++FDAGS+G+R+HV+ F Q         + E+F+ +KPGLSA+  +P+Q AE++
Sbjct: 44  AGTFYGIMFDAGSTGTRIHVYTFVQKTAGQLPFLEGEIFDSVKPGLSAFVDQPKQGAETV 103

Query: 124 VSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSDADA 183
             LLE A+  +PR    +TPV + ATAGLR L    +  +L  V ++ K+ S F     +
Sbjct: 104 QELLEVAKDSIPRSHWERTPVVLKATAGLRLLPEQKAQALLLEVEEIFKN-SPFLVPDGS 162

Query: 184 VTVLDGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAIS-ESEAAMAPQV 242
           V+++DG+ EG   WVT+N+L G L     +TVG +DLGG S Q+ +    E      P+ 
Sbjct: 163 VSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQFEKTLEQTPR- 221

Query: 243 MDGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEILKV-------AGDAENPCILSGS 295
                 Y+    +    + LY HSYL +GL AAR   L              + C+    
Sbjct: 222 -----GYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAKGTDGHTFRSACLPRWL 276

Query: 296 DGTYKYGGKSFKASSSGASLNECKSVAHKALKVNESTCTHMKCTFGGIWNGGGGDGQKNL 355
           +  + +GG  ++   +       +    + L+V +      +   G  +           
Sbjct: 277 EAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEVRGSAF----------- 325

Query: 356 FVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQTKLENAKSTYPRVEEGNLPYL 415
           +  S+++DRAA+   +D      +++  DFE  A++ C    +N  S          P+L
Sbjct: 326 YAFSYYYDRAADTHLIDYEKG-GVLKVEDFERKAREVC----DNLGSF-----SSGSPFL 375

Query: 416 CMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGSAIEAVSS 466
           CMDL Y   LL DGFG      + L KKV      +E  W LG+    + S
Sbjct: 376 CMDLTYITALLKDGFGFADGTLLQLTKKVNN----IETGWALGATFHLLQS 422


>ENP5_MESAU (Q9QYC8) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
           (Proto-oncogene cph)
          Length = 469

 Score =  173 bits (438), Expect = 1e-42
 Identities = 123/406 (30%), Positives = 195/406 (47%), Gaps = 38/406 (9%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLL 127
           Y ++FDAGS+G+R+HV+ F Q         + E+F+ +KPGLSA+A +P+Q A+++ +LL
Sbjct: 49  YGIMFDAGSTGTRIHVYTFVQKAAGQLPFLEGEIFDSVKPGLSAFADQPKQGAQTVHALL 108

Query: 128 EKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSDADAVTVL 187
           E A+  +PR    +TPV + ATAGLR L    +  +L  V ++ K  S F    D+V+++
Sbjct: 109 EVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQALLLEVEEIFK-MSPFLVPDDSVSIM 167

Query: 188 DGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVMDGED 247
           DG+ EG   WVT+N+L G L     +T+G +DLGG S Q+ +    S+      +     
Sbjct: 168 DGSYEGILAWVTVNFLTGQLHGHSQETMGTLDLGGASTQITFLPQFSKT-----LEQTPR 222

Query: 248 PYVKEMFLRGRKYYLYVHSYLRYGLLAARAEILKV-------AGDAENPCILSGSDGTYK 300
            Y+    +    + LY HSYL +GL AAR   L              + C+    +  + 
Sbjct: 223 DYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEWI 282

Query: 301 YGGKSFKASSSGASLNECKSVAHKALKVNESTCTHMKCTFGGIWNGGGGDGQKNLFVASF 360
           +GG  ++   +       +    + L+V +      +   G            + +  S+
Sbjct: 283 FGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEIRG-----------SSFYAFSY 331

Query: 361 FFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQTKLENAKSTYPRVEEGNLPYLCMDLV 420
           ++DRAA+   +D      +++  DFE  A++ C   LE+  S          P+LCMDL 
Sbjct: 332 YYDRAADTHLIDYEKG-GVLKVEDFERKAREVCD-NLESFTS--------GSPFLCMDLS 381

Query: 421 YQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGSAIEAVSS 466
           Y   LL DGFG      + L KKV      +E  WP G    A  S
Sbjct: 382 YITALLKDGFGFADGTLLQLTKKVNN----IETGWPGGHLSPAAVS 423


>GDA1_SCHPO (Q9UT35) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 556

 Score =  172 bits (437), Expect = 1e-42
 Identities = 135/426 (31%), Positives = 208/426 (48%), Gaps = 45/426 (10%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLL 127
           Y ++ DAGS+GSRVHV+ F+       + +  E F+ ++PGLS++A  P+ AA SL  LL
Sbjct: 134 YVLMIDAGSTGSRVHVYQFNNCNPSPKLEE--EFFKMIEPGLSSFAGDPEGAAASLDPLL 191

Query: 128 EKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSDADAVTVL 187
           + A   VP E R  +P+ + ATAGLR      +  IL++VR  L++   F    D V++L
Sbjct: 192 DYAMENVPEEYRRCSPIAVKATAGLRLTGESEAKAILKSVRQHLENDYPFPIVKDGVSIL 251

Query: 188 DGTQEGAYQWVTINYLLGNL-GKDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVMDGE 246
           +G+ EG Y W+TINYLLG L GK    TV V+DLGG S Q+ +      A+    ++DG+
Sbjct: 252 EGSMEGIYAWITINYLLGTLGGKATHSTVAVMDLGGASTQLVF--EPRFASDGESLVDGD 309

Query: 247 DPYVKEMFLRGRKYYLYVHSYLRYGLLAAR--------------AEILKVAGDAE---NP 289
             YV +    G +Y LY HS+L YGL  AR               E L++ GD+    +P
Sbjct: 310 HKYVLD--YNGEQYELYQHSHLGYGLKEARKLIHKFVLNNAEALKESLELLGDSTSIIHP 367

Query: 290 CI-----LSGSDGTYKYGGKSFKASSSGASLNECKSVAHKALKVNESTCTHMKCTFGGIW 344
           C+     L+  D   +     F   S      +C+ +A KAL   +  C    C+F G+ 
Sbjct: 368 CLHLNASLTHPDSKSEASEVVFVGPSLAHLSLQCRGIAEKAL-YKDKNCPVRPCSFNGVH 426

Query: 345 NGGGGD--GQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQACQ--TKLENA 400
                +      +++ S+F+DR    G        +     D +  A   C   T  ++A
Sbjct: 427 QPKFTETFTDSPIYLISYFYDRMISLGM------PSTFTIEDMKYLANSVCSGPTYWQDA 480

Query: 401 KSTYPRVEE-GNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDDALVEAAWPLGS 459
            S    ++E    P  C+DL Y  +LL  G+ I   +++   KK+       E  W LG+
Sbjct: 481 FSLTDALKELKEEPEWCLDLNYMISLLSVGYEIPNNRQLHTAKKIDNK----ELGWCLGA 536

Query: 460 AIEAVS 465
           ++  +S
Sbjct: 537 SLSMLS 542


>GDA1_ASPFU (Q8TGG8) Probable guanosine-diphosphatase (EC 3.6.1.42)
           (GDPase)
          Length = 558

 Score =  162 bits (411), Expect = 1e-39
 Identities = 135/452 (29%), Positives = 214/452 (46%), Gaps = 67/452 (14%)

Query: 62  KKSGGSYAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKP-----GLSAYAQKP 116
           KK    YA++ DAGS GSR+HV+ F+       +  + E+F Q +P     GLS+Y +  
Sbjct: 113 KKPLIQYALMIDAGSQGSRIHVYRFNNCGPSPEL--EDEVFFQTEPKKGGSGLSSYKEDA 170

Query: 117 QQAAESLVSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSS 176
           + AA+SL  L+E A   VP E +S +P+ + ATAGLR L  + S KIL AVR+ L+    
Sbjct: 171 EGAAKSLDPLMEVAMKNVPDEYKSCSPIAVKATAGLRMLGPELSQKILDAVRNRLETVYP 230

Query: 177 F---KSDADAVTVLDGTQEGAYQWVTINYLLGNLG-KDYSKTVGVVDLGGGSVQMAYAIS 232
           F     +   V ++DG+ EG Y W+T NYLLG +G  D + T  V DLGGGS Q+ +  +
Sbjct: 231 FPVVSKEKGGVEIMDGSDEGVYAWITTNYLLGKIGGPDETPTAAVFDLGGGSTQIVFQPT 290

Query: 233 ---ESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEILK-------- 281
                   M  ++ +G+  Y  ++   GR + LY HS+L YGL+AAR  I          
Sbjct: 291 FPKSKSGGMPERLSEGDHKY--DLQFGGRHFELYQHSHLGYGLMAARKAIHTSIIENMLA 348

Query: 282 --------VAGDAENPCILSGSDGT----YKYGGK-------SFKASSSGASLNECKSVA 322
                   +     NPCI    +      +  G K       +      G++  +C+ +A
Sbjct: 349 SSPKDLSWLKQPIPNPCIGPEMEKNVTLEFPEGHKLAPEVQVTMVGPKVGSTAAQCRGLA 408

Query: 323 HKALKVNESTCTHMKCTFGGIWNGGGGD--GQKNLFVASFFFDRAAEAGFVDPNSPVAIV 380
            K L   E+ CT   C+F G+          ++++++ S+F+DR    G  D  +     
Sbjct: 409 EKTLN-KEAACTLAPCSFNGVHQPSLEKTFAREDVYIFSYFYDRTKPLGMPDSFTL---- 463

Query: 381 RPADFEDAAKQACQTKL--ENAKSTYPRVEEG-----NLPYLCMDLVYQYTLLVDGFGIY 433
                 D   Q   T    E++   +  +E       + P  C+DL +  +LL  G+ + 
Sbjct: 464 ------DELHQLTSTVCGGEDSWGIFAGIEGALKELRDRPEWCLDLNFMMSLLHTGYEMP 517

Query: 434 PWQEITLVKKVKYDDALVEAAWPLGSAIEAVS 465
             +E+ + KK+K      E  W LG+++  +S
Sbjct: 518 LSREVKIAKKIKNR----ELGWCLGASLPLLS 545


>GDA1_CANAL (Q8TGH6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 599

 Score =  160 bits (405), Expect = 7e-39
 Identities = 137/437 (31%), Positives = 199/437 (45%), Gaps = 61/437 (13%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLL 127
           Y V+ DAGS+GSRVHV+ F+  +    +    E FE LKPGLS++      AA+SL  LL
Sbjct: 163 YVVMIDAGSTGSRVHVYEFNTCVKPPQLLS--EEFEMLKPGLSSFDTDTVGAAKSLDPLL 220

Query: 128 EKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFK-SDADAVTV 186
           E A   VP+  +S TPV + ATAGLR L    S  IL  VR  L+    F     D +++
Sbjct: 221 EVALKKVPKNKQSCTPVAVKATAGLRLLGETKSKAILDEVRSHLEKDYPFAVVSEDGISI 280

Query: 187 LDGTQEGAYQWVTINYLLGNL-GKDYSKTVGVVDLGGGSVQMAYAISESEAAMAPQVMDG 245
           +DG  EG Y WVT NYLLGN+ GK+   T  V DLGGGS Q+ +   E +  +    +DG
Sbjct: 281 MDGKDEGVYAWVTANYLLGNIGGKEKLPTAAVFDLGGGSTQIVF---EPDYKVDEVPVDG 337

Query: 246 EDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEI------------------------LK 281
           E  Y         +Y LY  S+L YGL+  R ++                         K
Sbjct: 338 ETKY--HFTFGDNQYTLYQFSHLGYGLMQGRNKVNQLVLKNKLSELNLQKYTKKEVKGAK 395

Query: 282 VAGDAENPCILSG---SDGTYKYGGKSF---------KASSSGASLNECKSVAHKALKVN 329
              D  NPCI  G    D   + G   F            S+ A  ++C+ +A K L   
Sbjct: 396 ATVDVSNPCIPPGVVAKDVQVELGEDEFYVVNMKGPSSKDSTVAGGSQCRYLAEKVLN-K 454

Query: 330 ESTCTHMKCTFGGIWNGG---GGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFE 386
           ++ CT   C+F G+         +   +++V S+F+DR    G   P+S        + +
Sbjct: 455 DAECTSKPCSFNGVHQPSLTRTFNKNSDMYVFSYFYDRTNPIGM--PSS----FSVEELK 508

Query: 387 DAAKQACQ--TKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKV 444
           D +K  CQ  T  ++             P  C+DL +   +L  G+ I   +E+   K +
Sbjct: 509 DLSKLVCQGETFWKDILLDDHVKNLNEEPQWCLDLSFITAMLHTGYDIPLHRELKTAKTI 568

Query: 445 KYDDALVEAAWPLGSAI 461
             +    E  W LG+++
Sbjct: 569 DNN----ELGWCLGASL 581


>GDA1_YEAST (P32621) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 518

 Score =  151 bits (381), Expect = 4e-36
 Identities = 131/433 (30%), Positives = 205/433 (47%), Gaps = 61/433 (14%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSLL 127
           Y ++ DAGS+GSRVH++ FD       +    E F+ L+PGLS++      AA SL  LL
Sbjct: 93  YVIMIDAGSTGSRVHIYKFDVCTSPPTLLD--EKFDMLEPGLSSFDTDSVGAANSLDPLL 150

Query: 128 EKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFK-SDADAVTV 186
           + A   VP + RS TPV + ATAGLR L    S KIL AVRD L+    F   + D V++
Sbjct: 151 KVAMNYVPIKARSCTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSI 210

Query: 187 LDGTQEGAYQWVTINYLLGNLGKDYSK--TVGVVDLGGGSVQMAYAISESEAAMAPQVMD 244
           + G +EG + W+T NYLLGN+G +  K  T  V DLGGGS Q+ +   E    +  +++D
Sbjct: 211 MGGDEEGVFAWITTNYLLGNIGANGPKLPTAAVFDLGGGSTQIVF---EPTFPINEKMVD 267

Query: 245 GEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAEILKV------------AGD------A 286
           GE  +  ++      Y LY  S+L YGL   R ++  V             GD       
Sbjct: 268 GEHKF--DLKFGDENYTLYQFSHLGYGLKEGRNKVNSVLVENALKDGKILKGDNTKTHQL 325

Query: 287 ENPCILSGSDGTYKYGGKSFKAS----------SSGASLNECKSVAHKALKVNESTCTHM 336
            +PC+    + T +      K +           SGA   +C+ +  + L   ++ C   
Sbjct: 326 SSPCLPPKVNATNEKVTLESKETYTIDFIGPDEPSGA---QCRFLTDEILN-KDAQCQSP 381

Query: 337 KCTFGGIWNGG---GGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQAC 393
            C+F G+             ++++ S+F+DR    G      P++     +  D A+  C
Sbjct: 382 PCSFNGVHQPSLVRTFKESNDIYIFSYFYDRTRPLGM-----PLSFTL-NELNDLARIVC 435

Query: 394 QTKLENAKSTYPRV-----EEGNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDD 448
           + + E   S +  +     E  +  + C+DL +Q +LL  G+ I   +E+   KK+    
Sbjct: 436 KGE-ETWNSVFSGIAGSLDELESDSHFCLDLSFQVSLLHTGYDIPLQRELRTGKKI---- 490

Query: 449 ALVEAAWPLGSAI 461
           A  E  W LG+++
Sbjct: 491 ANKEIGWCLGASL 503


>ENP1_MOUSE (P55772) Ectonucleoside triphosphate diphosphohydrolase
           1 (EC 3.6.1.5) (NTPDase1) (Ecto-ATP diphosphohydrolase)
           (ATPDase) (Lymphoid cell activation antigen)
           (Ecto-apyrase) (CD39 antigen)
          Length = 510

 Score =  137 bits (346), Expect = 5e-32
 Identities = 121/436 (27%), Positives = 193/436 (43%), Gaps = 76/436 (17%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDL-VHIGKDLELFEQLKPGLSAYAQKPQQAAESLVSL 126
           Y ++ DAGSS + ++++ +    +    + + LE  +   PG+S YAQK  +    L   
Sbjct: 49  YGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKTDEIGAYLAEC 108

Query: 127 LEKAEGVVPRELRSKTPVRIGATAGLRALEGDA---SDKILRAVRDLLKHRSSFKSDADA 183
           +E +  ++P     +TPV +GATAG+R L  ++   +D++L AV   LK   S+  D   
Sbjct: 109 MELSTELIPTSKHHQTPVYLGATAGMRLLRMESEQSADEVLAAVSTSLK---SYPFDFQG 165

Query: 184 VTVLDGTQEGAYQWVTINYLLGNLGKDYS-----------KTVGVVDLGGGSVQMAYAIS 232
             ++ G +EGAY W+TINYLLG   ++ S           +T G +DLGG S Q+ +   
Sbjct: 166 AKIITGQEEGAYGWITINYLLGRFTQEQSWLSLISDSQKQETFGALDLGGASTQITF--- 222

Query: 233 ESEAAMAPQVMDGEDPYVKEMF-LRGRKYYLYVHSYLRYG----LLAARAEILKVA--GD 285
                  PQ    E P     F L G  Y +Y HS+L YG    L    A+ ++V+  G 
Sbjct: 223 ------VPQNSTIESPENSLQFRLYGEDYTVYTHSFLCYGKDQALWQKLAKDIQVSSGGV 276

Query: 286 AENPCI------------LSGSDGTYKYGGK----SFKASSSGASLNECKSVAHKAL--K 327
            ++PC             L G+  T ++  K     F+   +G    +C    H+++   
Sbjct: 277 LKDPCFNPGYEKVVNVSELYGTPCTKRFEKKLPFDQFRIQGTG-DYEQC----HQSILEL 331

Query: 328 VNESTCTHMKCTFGGIW----NGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPA 383
            N S C + +C F G++    +G  G      FV  FF   A            +++   
Sbjct: 332 FNNSHCPYSQCAFNGVFLPPLHGSFGAFSAFYFVMDFFKKVAKN----------SVISQE 381

Query: 384 DFEDAAKQACQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVD-GFGIYPWQEITLVK 442
              +  K  C    E  K++YP V+E  L   C    Y  +LL    F    W++I  + 
Sbjct: 382 KMTEITKNFCSKSWEETKTSYPSVKEKYLSEYCFSGAYILSLLQGYNFTDSSWEQIHFMG 441

Query: 443 KVKYDDALVEAAWPLG 458
           K+K  +    A W LG
Sbjct: 442 KIKDSN----AGWTLG 453


>ENP1_RAT (P97687) Ectonucleoside triphosphate diphosphohydrolase 1
           (EC 3.6.1.5) (NTPDase1) (Ecto-ATP diphosphohydrolase)
           (ATPDase) (Lymphoid cell activation antigen)
           (Ecto-apyrase) (CD39 antigen)
          Length = 511

 Score =  136 bits (342), Expect = 1e-31
 Identities = 117/434 (26%), Positives = 191/434 (43%), Gaps = 71/434 (16%)

Query: 68  YAVIFDAGSSGSRVHVFHF----DQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESL 123
           Y ++ DAGSS + ++++ +    + +  +V +   LE  +   PG+S YAQK  + A  L
Sbjct: 49  YGIVLDAGSSHTNLYIYKWPAEKENDTGVVQL---LEECQVKGPGISKYAQKTDEIAAYL 105

Query: 124 VSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDA---SDKILRAVRDLLKHRSSFKSD 180
              ++ +   +P   + +TPV +GATAG+R L  ++   +D++L AV   LK   S+  D
Sbjct: 106 AECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLK---SYPFD 162

Query: 181 ADAVTVLDGTQEGAYQWVTINYLLGNLGKDYS-----------KTVGVVDLGGGSVQMAY 229
                ++ G +EGAY W+TINYLLG   ++ S            T G +DLGG S Q+ +
Sbjct: 163 FQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTF 222

Query: 230 AISESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYG----LLAARAEILKVA-- 283
            +  ++   AP+          +  L G  Y +Y HS+L YG    L    A+ ++V+  
Sbjct: 223 -VPLNQTLEAPETS-------LQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSG 274

Query: 284 GDAENPCILSGSDGTYK----YGGKSFKASSSGASLNECK-------SVAHKALK--VNE 330
           G  ++PC   G          YG    K        N+ +          H+++    N 
Sbjct: 275 GILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNN 334

Query: 331 STCTHMKCTFGGIW----NGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFE 386
           S C + +C F G++     G  G      FV  FF   A +          ++       
Sbjct: 335 SHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMAND----------SVSSQEKMT 384

Query: 387 DAAKQACQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFGI--YPWQEITLVKKV 444
           +  K  C    E  K++YP V+E  L   C    Y  +LL+ G+      W +I  + K+
Sbjct: 385 EITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKI 444

Query: 445 KYDDALVEAAWPLG 458
           K  +    A W LG
Sbjct: 445 KDSN----AGWTLG 454


>ENP2_CHICK (P79784) Ectonucleoside triphosphate diphosphohydrolase
           2 (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39
           antigen-like 1)
          Length = 494

 Score =  127 bits (320), Expect = 5e-29
 Identities = 114/398 (28%), Positives = 174/398 (43%), Gaps = 56/398 (14%)

Query: 68  YAVIFDAGSSGSRVHVFHF--DQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVS 125
           Y ++ DAGSS + V ++ +  D+  D   +  +  + +   PG+S+Y+ KP  A +SL  
Sbjct: 37  YGIVLDAGSSHTAVFIYKWPADKEND-TGVVSEHSMCDVEGPGISSYSSKPPAAGKSLEH 95

Query: 126 LLEKAEGVVPRELRSKTPVRIGATAGLRAL--EGDASDKILRAVRDLLKHRSSFKSDADA 183
            L +A   VP+E  + TP+ +GATAG+R L      S   L AV   LK   S+  D   
Sbjct: 96  CLSQAMRDVPKEKHADTPLYLGATAGMRLLTIADPPSQTCLSAVMATLK---SYPFDFGG 152

Query: 184 VTVLDGTQEGAYQWVTINYLLGNLGK---------DYSKTVGVVDLGGGSVQMAYAISES 234
             +L G +EG + W+T NYLL N  K            KT+G +D GG S Q+ +  S++
Sbjct: 153 AKILSGEEEGVFGWITANYLLENFIKRGWLGEWIQSKKKTLGAMDFGGASTQITFETSDA 212

Query: 235 EAAMAPQVMDGEDPYVKEMF-LRGRKYYLYVHSYLRYGLLAARAEILKVAGDAE------ 287
                      EDP  + M  L G+ Y +Y HS+L YG       +L     AE      
Sbjct: 213 I----------EDPKNEVMLKLYGQPYKVYTHSFLCYGRDQVLKRLLSKVLQAENYQETV 262

Query: 288 -NPCILSGSDGTYK----YGGKSFKASSSGASLNECKSVAHK------ALKVNE----ST 332
            NPC  +G   +      Y     +    G  LN    V+        A+ VN+    ++
Sbjct: 263 ANPCWPTGYRKSLSLSSIYDSPCTEKERPGLPLNTTVVVSGTGNGNLCAVHVNKLFDFTS 322

Query: 333 CTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQA 392
           C+   C+F G++     +   N    S FF       F+       +  P+D +DAA+  
Sbjct: 323 CSFSHCSFDGVFQ---PEVSGNFIAFSAFF---YTVDFIRTVMERPVHSPSDLKDAAETI 376

Query: 393 CQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGF 430
           C T         PR+E+  LP  C    + Y L+  G+
Sbjct: 377 CATSWNELYQKAPRLEK-RLPDYCATSTFVYLLITKGY 413


>MI23_CAEEL (Q21815) Nucleoside-diphosphatase mig-23 (EC 3.6.1.-)
           (NDPase) (Abnormal cell migration protein 23)
          Length = 552

 Score =  123 bits (309), Expect = 9e-28
 Identities = 112/432 (25%), Positives = 195/432 (44%), Gaps = 47/432 (10%)

Query: 67  SYAVIFDAGSSGSRVHVFHFDQNLD--LVHIGKDL----ELFEQLKPGLSAYAQKPQQAA 120
           SY VI DAGS+G+R+ V+++    D  L+ I   +     + +++ PGLS +  KP QAA
Sbjct: 43  SYGVICDAGSTGTRLFVYNWISTSDSELIQIEPVIYDNKPVMKKISPGLSTFGTKPAQAA 102

Query: 121 ESLVSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHRSSFKSD 180
           E L  L+E AE  +P E R  TPV I ATAG+R +  +  + +L+ +R+ L   +S +  
Sbjct: 103 EYLRPLMELAERHIPEEKRPYTPVFIFATAGMRLIPDEQKEAVLKNLRNKLPKITSMQVL 162

Query: 181 ADAVTVLDGTQEGAYQWVTINYLLGNLGK----DY---------SKTVGVVDLGGGSVQM 227
            + + +++G  EG Y W+ +NY LG   K    D+          KTVG++D+GG S Q+
Sbjct: 163 KEHIRIIEGKWEGIYSWIAVNYALGKFNKTATLDFPGTSPAHARQKTVGMIDMGGASAQI 222

Query: 228 AYAISESEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYGLLAARAE----ILKVA 283
           A+ + ++++  +  V +      ++  L   KY L+V ++L YG+     +    +L   
Sbjct: 223 AFELPDTDSFSSINVENINLGCREDDSL--FKYKLFVTTFLGYGVNEGIRKYEHMLLSKL 280

Query: 284 GDAENPCI------LSGSDGTYKYGGKSFKASSSGASLNECKSVAHKALKVNEST----C 333
            D     I      L+         G++F    +G + N C +   K L    S+     
Sbjct: 281 KDQNGTVIQDDCMPLNLHKTVTLENGENFVRRGTG-NWNTCSNEVKKLLNPESSSEVCKA 339

Query: 334 THMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQAC 393
              KC FG +           ++  S ++    +   +        +     +  +K+  
Sbjct: 340 EAAKCYFGAVPAPSIPLSNIEMYGFSEYWYSTHDVLGLGGQYDAENIAKKTQQYCSKRWS 399

Query: 394 QTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFGI----YPWQEITLVKKVKYDDA 449
             + E+ K  YPR +E  L   C    +  ++L DGF +      +Q ++ +       A
Sbjct: 400 TIQAESKKQLYPRADEERLRTQCFKSAWITSVLHDGFSVDKTHNKFQSVSTI-------A 452

Query: 450 LVEAAWPLGSAI 461
             E  W LG+ I
Sbjct: 453 GQEVQWALGAMI 464


>YND1_YEAST (P40009) Golgi apyrase (EC 3.6.1.5) (ATP-diphosphatase)
           (Adenosine diphosphatase) (ADPase)
           (ATP-diphosphohydrolase) (Golgi nucleoside
           diphosphatase)
          Length = 630

 Score =  119 bits (298), Expect = 2e-26
 Identities = 99/323 (30%), Positives = 151/323 (46%), Gaps = 56/323 (17%)

Query: 68  YAVIFDAGSSGSRVHVFHFDQNLDLVH---------------IGKDLELFEQLKPGLSAY 112
           + ++ DAGSSGSR+HVF +     L+H               I ++ +   +L PGLS++
Sbjct: 10  FGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSF 69

Query: 113 AQKPQQAAESLVS-LLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLL 171
            +KPQ A +S +  LL+ A+ ++P    S  PV I ATAG+R L  D    IL  +   L
Sbjct: 70  EKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGL 129

Query: 172 KHRSSF-KSDADA-VTVLDGTQEGAYQWVTINYLLGNLGKDYSK------TVGVVDLGGG 223
           KH + F   D  A + V+DG  EG Y W+ +NYL G+   DY+       T G +D+GG 
Sbjct: 130 KHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHF-NDYNPEVSDHFTFGFMDMGGA 188

Query: 224 SVQMAYAISESEAAMAPQVMDGEDPYVKEMFLRG-----RKYYLYVHSYLRYGLLAARAE 278
           S Q+A+A  +S      ++    D  +  +FLR      +K+ ++V ++L +G   AR  
Sbjct: 189 STQIAFAPHDS-----GEIARHRDD-IATIFLRSVNGDLQKWDVFVSTWLGFGANQARRR 242

Query: 279 IL--------KVAGDAEN----------PCILSGSDGTYKYGGKSFKASSSGASLNECKS 320
            L        +   D EN          PC+  GS   +++    F  + SG      KS
Sbjct: 243 YLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKS 302

Query: 321 VAHKALKVNESTCTHMKCTFGGI 343
           +    LK     C    C F G+
Sbjct: 303 IYPLLLK--NMPCDDEPCLFNGV 323


>NTP1_CAEEL (Q18411) Putative nucleoside-triphosphatase ntp-1 (EC
           3.6.1.15)
          Length = 485

 Score =  117 bits (293), Expect = 6e-26
 Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 10/218 (4%)

Query: 61  DKKSGGSYAVIFDAGSSGSRVHVFHFDQ------NLDLVHIGKDLELFEQLKPGLSAYAQ 114
           + K+   Y VI DAGSSG+R+ V+          N+D + I +   + +++ PGLS++  
Sbjct: 18  ETKNNIKYGVICDAGSSGTRLFVYTLKPLSGGLTNIDTL-IHESEPVVKKVTPGLSSFGD 76

Query: 115 KPQQAAESLVSLLEKAEGVVPRELRSKTPVRIGATAGLRALEGDASDKILRAVRDLLKHR 174
           KP+Q  E L  LL  AE  +P E   +T + I ATAG+R L     D I++ +++ LK  
Sbjct: 77  KPEQVVEYLTPLLRFAEEHIPYEQLGETDLLIFATAGMRLLPEAQKDAIIKNLQNGLKSV 136

Query: 175 SSFKSDADAVTVLDGTQEGAYQWVTINYLLGNLGKDYSKTVGVVDLGGGSVQMAYAI-SE 233
           ++ +     + ++DG  EG Y W+ +NY+LG   K+    VG++D+GG SVQ+A+ I +E
Sbjct: 137 TALRVSDSNIRIIDGAWEGIYSWIAVNYILGRFDKENDSKVGMIDMGGASVQIAFEIANE 196

Query: 234 SEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYG 271
            E+     V +     ++       KY +Y  ++L YG
Sbjct: 197 KESYNGGNVYEINLGSIETN--EDYKYKIYSTTFLGYG 232


>ENP2_MOUSE (O55026) Ectonucleoside triphosphate diphosphohydrolase
           2 (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39
           antigen-like 1)
          Length = 495

 Score =  112 bits (281), Expect = 2e-24
 Identities = 115/428 (26%), Positives = 185/428 (42%), Gaps = 65/428 (15%)

Query: 68  YAVIFDAGSSGSRVHVFHF--DQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVS 125
           Y ++ DAGSS + + V+ +  D+  D   +G+     +    G+S+YA  P +A +SLV 
Sbjct: 40  YGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSC-DVRGGGISSYANDPSRAGQSLVE 98

Query: 126 LLEKAEGVVPRELRSKTPVRIGATAGLRALE---GDASDKILRAVRDLLKHRSSFKSDAD 182
            LE+A   VP++  + TP+ +GATAG+R L     +A+ K+L AV   L   + +  D  
Sbjct: 99  CLEQALRDVPKDRYASTPLYLGATAGMRLLNLTSPEATAKVLEAVTQTL---TRYPFDFR 155

Query: 183 AVTVLDGTQEGAYQWVTINYLLGNLGK---------DYSKTVGVVDLGGGSVQMAYAISE 233
              +L G  EG + WVT NYLL N  K             T+G +DLGG S Q+ +  + 
Sbjct: 156 GARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTS 215

Query: 234 SEAAMAPQVMDGEDPYVKEMFLR--GRKYYLYVHSYLRYG-------LLAARAEI----- 279
                       EDP   E+ LR  G+ Y +Y HS+L YG       LLA+  +I     
Sbjct: 216 ----------PSEDP-DNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLASALQIHRFHP 264

Query: 280 ---------LKVAGDAENPCILSGSDGTYKYGGKSFKASSSGASLNECKSVAHKALKVNE 330
                    + +    ++PC +     T+        + +S A+L  C+ +       N 
Sbjct: 265 CWPKGYSTQVLLREVYQSPCTMGQRPQTFNSSATVSLSGTSNAAL--CRDLVSGLF--NI 320

Query: 331 STCTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAK 390
           S+C   +C+F G++           F+A   F    +        PV  ++    EDA +
Sbjct: 321 SSCPFSQCSFNGVFQPPVAGN----FIAFSAFYYTVDFLKTVMGLPVGTLK--QLEDATE 374

Query: 391 QACQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFGIYPWQEITLVKKVKYDDAL 450
             C       ++  P  ++  LP  C   ++ + LL  G+         +V + K  D  
Sbjct: 375 TTCNQTWAELQARVPG-QQTRLPDYCAVAMFIHQLLSRGYRFDERSFRGVVFEKKAADTA 433

Query: 451 VEAAWPLG 458
           V   W LG
Sbjct: 434 V--GWALG 439


>ENP2_HUMAN (Q9Y5L3) Ectonucleoside triphosphate diphosphohydrolase
           2 (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39
           antigen-like 1)
          Length = 495

 Score =  110 bits (276), Expect = 6e-24
 Identities = 106/399 (26%), Positives = 171/399 (42%), Gaps = 59/399 (14%)

Query: 68  YAVIFDAGSSGSRVHVFHF--DQNLDLVHIGKDLELFEQLKPGLSAYAQKPQQAAESLVS 125
           Y ++ DAGSS + + ++ +  D+  D   +G+     +    G+S+YA  P  A++SLV 
Sbjct: 40  YGIVLDAGSSHTSMFIYKWPADKENDTGIVGQHSSC-DVPGGGISSYADNPSGASQSLVG 98

Query: 126 LLEKAEGVVPRELRSKTPVRIGATAGLRAL---EGDASDKILRAVRDLLKHRSSFKSDAD 182
            LE+A   VP+E  + TP+ +GATAG+R L     +AS  +L AV   L   + +  D  
Sbjct: 99  CLEQALQDVPKERHAGTPLYLGATAGMRLLNLTNPEASTSVLMAVTHTL---TQYPFDFR 155

Query: 183 AVTVLDGTQEGAYQWVTINYLLGNLGK---------DYSKTVGVVDLGGGSVQMAYAISE 233
              +L G +EG + WVT NYLL N  K             T+G +DLGG S Q+ +  + 
Sbjct: 156 GARILSGQEEGVFGWVTANYLLENFIKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTS 215

Query: 234 SEAAMAPQVMDGEDPYVKEMFLRGRKYYLYVHSYLRYG-------LLAARAE-------- 278
                A +V         ++ L G+ Y +Y HS+L YG       LLA+  +        
Sbjct: 216 PAEDRASEV---------QLHLYGQHYRVYTHSFLCYGRDQVLQRLLASALQTHGFHPCW 266

Query: 279 -----ILKVAGDA-ENPCILSGSDGTYKYGGKSFKASSSGASLNECKSVAHKALKVNEST 332
                   + GD  ++PC ++     +    +   + SS   L  C+ +         S+
Sbjct: 267 PRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVSLSGSSDPHL--CRDLVSGLFSF--SS 322

Query: 333 CTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDPNSPVAIVRPADFEDAAKQA 392
           C   +C+F G++           FVA   F    +        PVA ++    E AA   
Sbjct: 323 CPFSRCSFNGVFQPPVAGN----FVAFSAFFYTVDFLRTSMGLPVATLQ--QLEAAAVNV 376

Query: 393 CQTKLENAKSTYPRVEEGNLPYLCMDLVYQYTLLVDGFG 431
           C       ++  P  +   L   C   ++   LL  G+G
Sbjct: 377 CNQTWAQLQARVPG-QRARLADYCAGAMFVQQLLSRGYG 414


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.317    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,511,041
Number of Sequences: 164201
Number of extensions: 2343884
Number of successful extensions: 6243
Number of sequences better than 10.0: 44
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 6110
Number of HSP's gapped (non-prelim): 56
length of query: 467
length of database: 59,974,054
effective HSP length: 114
effective length of query: 353
effective length of database: 41,255,140
effective search space: 14563064420
effective search space used: 14563064420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)