BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC122160.6 + phase: 0
(466 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha sub... 603 e-172
IMA1_ARATH (Q96321) Importin alpha-1 subunit (Karyopherin alpha-... 591 e-168
IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-... 540 e-153
IMA7_MOUSE (O35345) Importin alpha-7 subunit (Karyopherin alpha-... 426 e-119
IMA7_HUMAN (O60684) Importin alpha-7 subunit (Karyopherin alpha-6) 425 e-118
IMA5_HUMAN (O15131) Importin alpha-6 subunit (Karyopherin alpha-... 420 e-117
IMA1_HUMAN (P52294) Importin alpha-1 subunit (Karyopherin alpha-... 410 e-114
IMA1_RAT (P83953) Importin alpha-1 subunit (Karyopherin alpha-1 ... 409 e-113
IMA1_MOUSE (Q60960) Importin alpha-1 subunit (Karyopherin alpha-... 406 e-113
IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha su... 399 e-110
IMA1_YEAST (Q02821) Importin alpha subunit (Karyopherin alpha su... 398 e-110
IMA2_MOUSE (P52293) Importin alpha-2 subunit (Karyopherin alpha-... 351 3e-96
IMA2_XENLA (P52171) Importin alpha-2 subunit (Karyopherin alpha-... 348 2e-95
IMA2_HUMAN (P52292) Importin alpha-2 subunit (Karyopherin alpha-... 343 4e-94
IMA1_XENLA (P52170) Importin alpha-1 subunit (Karyopherin alpha-... 340 6e-93
IMA4_MOUSE (O35343) Importin alpha-4 subunit (Karyopherin alpha-... 336 9e-92
IMA4_HUMAN (O00629) Importin alpha-4 subunit (Karyopherin alpha-... 336 9e-92
IMA3_MOUSE (O35344) Importin alpha-3 subunit (Karyopherin alpha-... 332 1e-90
IMA3_HUMAN (O00505) Importin alpha-3 subunit (Karyopherin alpha-... 330 4e-90
IMA_DROME (P52295) Importin alpha subunit (Karyopherin alpha sub... 324 3e-88
>IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha
subunit) (KAP alpha)
Length = 527
Score = 603 bits (1556), Expect = e-172
Identities = 307/459 (66%), Positives = 360/459 (77%), Gaps = 38/459 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
++A +WSDD+S QLE TT+FRK LS+++ PPI++VIQSGVVPRFV+FL + D+PQLQ EA
Sbjct: 78 LIAGVWSDDSSLQLECTTQFRKLLSIERNPPIEEVIQSGVVPRFVEFLARDDYPQLQFEA 137
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSENTKVV+D+G+VP+F++LLSSP DDVR QA WALGNIAGDSP+ RDLV
Sbjct: 138 AWALTNIASGTSENTKVVIDYGSVPIFIRLLSSPSDDVREQAVWALGNIAGDSPKYRDLV 197
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGKPQPALEQVRSALPALKCLVFSKDE 179
L HGAL+ LL+Q NEQ L LRNA WTLSNFCRGKPQP EQ ++ALP L L+ S DE
Sbjct: 198 LGHGALVALLAQFNEQAKLSMLRNATWTLSNFCRGKPQPLFEQTKAALPTLGRLIHSNDE 257
Query: 180 VVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDD 239
VLT+ACWALSYLSDGT+D IQAVIEAGVC RLV++LL S S L PALRTVGNIV+GDD
Sbjct: 258 EVLTDACWALSYLSDGTNDKIQAVIEAGVCSRLVELLLHSSPSVLIPALRTVGNIVTGDD 317
Query: 240 MQTQAIVNHGLLPCLLSLLT-HPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
+QTQ +++H LPCL++LLT + KKSIKKEAC T+SNITAGNR QIQ VIEAG+IAPLV
Sbjct: 318 IQTQVMIDHHALPCLVNLLTQNYKKSIKKEACWTISNITAGNRNQIQIVIEAGIIAPLVY 377
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 358
LLQNAEF+I KE A A++N TSGG H+ IK+LVSQGCIKPLCDLLVCPDPRIVTVCLEGL
Sbjct: 378 LLQNAEFEIKKEAAWAISNATSGGNHDQIKFLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 437
Query: 359 ENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQ 418
EN LK+GEA+K + NT VN+YAQ I + EG
Sbjct: 438 ENILKIGEADKDLGNTEGVNVYAQLIDEAEG----------------------------- 468
Query: 419 MIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDED 457
LEKIENL SH++ EIYEKA KILE YWLE+ED
Sbjct: 469 -------LEKIENLQSHDNTEIYEKAVKILETYWLEEED 500
>IMA1_ARATH (Q96321) Importin alpha-1 subunit (Karyopherin alpha-1
subunit) (KAP alpha)
Length = 532
Score = 591 bits (1523), Expect = e-168
Identities = 301/460 (65%), Positives = 359/460 (77%), Gaps = 38/460 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
MVA +WSDD + QLE+TT+FRK LS+++ PPI++VI +GVVPRFV+FL K D+P +Q EA
Sbjct: 77 MVAGVWSDDPALQLESTTQFRKLLSIERSPPIEEVISAGVVPRFVEFLKKEDYPAIQFEA 136
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTS++TKVV+DH AVP+FV+LL+SP DDVR QA WALGN+AGDSPR RDLV
Sbjct: 137 AWALTNIASGTSDHTKVVIDHNAVPIFVQLLASPSDDVREQAVWALGNVAGDSPRCRDLV 196
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGKPQPALEQVRSALPALKCLVFSKDE 179
L GAL+ LL+QLNE L LRNA WTLSNFCRGKPQP +QV+ ALPAL+ L+ S DE
Sbjct: 197 LGCGALLPLLNQLNEHAKLSMLRNATWTLSNFCRGKPQPHFDQVKPALPALERLIHSDDE 256
Query: 180 VVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDD 239
VLT+ACWALSYLSDGT+D IQ VI+AGV +LV++LL S S L PALRTVGNIV+GDD
Sbjct: 257 EVLTDACWALSYLSDGTNDKIQTVIQAGVVPKLVELLLHHSPSVLIPALRTVGNIVTGDD 316
Query: 240 MQTQAIVNHGLLPCLLSLLT-HPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
+QTQ ++N G LPCL +LLT + KKSIKKEAC T+SNITAGN++QIQ V+EA LI+PLV+
Sbjct: 317 IQTQCVINSGALPCLANLLTQNHKKSIKKEACWTISNITAGNKDQIQTVVEANLISPLVS 376
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 358
LLQNAEFDI KE A A++N TSGG+H+ IKYLV QGCIKPLCDLLVCPDPRI+TVCLEGL
Sbjct: 377 LLQNAEFDIKKEAAWAISNATSGGSHDQIKYLVEQGCIKPLCDLLVCPDPRIITVCLEGL 436
Query: 359 ENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQ 418
EN LKVGEAEK++ +TGD+N YAQ I D EG
Sbjct: 437 ENILKVGEAEKNLGHTGDMNYYAQLIDDAEG----------------------------- 467
Query: 419 MIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
LEKIENL SH++ EIYEKA KILE YWLE+ED+
Sbjct: 468 -------LEKIENLQSHDNNEIYEKAVKILETYWLEEEDD 500
>IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-2
subunit) (KAP alpha)
Length = 531
Score = 540 bits (1391), Expect = e-153
Identities = 279/460 (60%), Positives = 344/460 (74%), Gaps = 38/460 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
MVA IWS+D++ QLEAT RK LS+++ PPI++V+QSGVVPR V+FL + DFP+LQ EA
Sbjct: 80 MVAGIWSEDSNSQLEATNLLRKLLSIEQNPPINEVVQSGVVPRVVKFLSRDDFPKLQFEA 139
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSENT V+++ GAVP+F++LLSS +DVR QA WALGN+AGDSP+ RDLV
Sbjct: 140 AWALTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKCRDLV 199
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGKPQPALEQVRSALPALKCLVFSKDE 179
LS+GA+ LLSQ NE L LRNA WTLSNFCRGKP PA EQ + ALP L+ LV S DE
Sbjct: 200 LSYGAMTPLLSQFNENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPALPVLERLVQSMDE 259
Query: 180 VVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDD 239
VLT+ACWALSYLSD ++D IQAVIEAGV RL+Q+L S S L PALRT+GNIV+GDD
Sbjct: 260 EVLTDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDD 319
Query: 240 MQTQAIVNHGLLPCLLSLL-THPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
+QTQ +++ LPCLL+LL + KKSIKKEAC T+SNITAGN +QIQAVI+AG+I LV
Sbjct: 320 LQTQMVLDQQALPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVW 379
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 358
+LQ+AEF++ KE A ++N TSGGTH+ IK++VSQGCIKPLCDLL CPD ++VTVCLE L
Sbjct: 380 VLQSAEFEVKKEAAWGISNATSGGTHDQIKFMVSQGCIKPLCDLLTCPDLKVVTVCLEAL 439
Query: 359 ENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQ 418
EN L VGEAEK++ +TG+ NLYAQ I + EG
Sbjct: 440 ENILVVGEAEKNLGHTGEDNLYAQMIDEAEG----------------------------- 470
Query: 419 MIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
LEKIENL SH++ +IY+KA KILE +W ED +E
Sbjct: 471 -------LEKIENLQSHDNNDIYDKAVKILETFWTEDNEE 503
>IMA7_MOUSE (O35345) Importin alpha-7 subunit (Karyopherin alpha-6
subunit) (Importin alpha S2)
Length = 533
Score = 426 bits (1095), Expect = e-119
Identities = 241/464 (51%), Positives = 305/464 (64%), Gaps = 41/464 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQS-GVVPRFVQFLDKGDFPQLQLE 58
MV ++SDD+ QL T +FRK LS + PPID+VI + GVV RFV+FL + + LQ E
Sbjct: 82 MVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPGVVDRFVEFLKRNENCTLQFE 141
Query: 59 AAWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDL 118
AAWALTNIA+GTS+ TK+V++ GAVP+F++LL+S +DV+ QA WALGNIAGDS RD
Sbjct: 142 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSLCRDY 201
Query: 119 VLSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSK 177
VL+ L LL+ L + L RNAVW LSN CRGK P P +V LP L L+FS
Sbjct: 202 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSS 261
Query: 178 DEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSG 237
D +L +ACWALSYLSDG ++ IQAVI++GVC RLV++L+ PALR VGNIV+G
Sbjct: 262 DSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTG 321
Query: 238 DDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLV 297
DD+QTQ I+N LPCLL LL+ K+SI+KEAC T+SNITAGNR QIQAVI+A + L+
Sbjct: 322 DDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLI 381
Query: 298 NLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEG 357
+LQ AEF KE A A+TN TSGGT E I+YLVS GCIKPLCDLL D +IV V L G
Sbjct: 382 EILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNG 441
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
LEN L++GE E S +G VN Y I++ G
Sbjct: 442 LENILRLGEQESKRSGSG-VNPYCGLIEEAYG---------------------------- 472
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYW-LEDEDETL 460
L+KIE L SHE++EIY+KA ++E Y+ +ED+D +L
Sbjct: 473 --------LDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSL 508
>IMA7_HUMAN (O60684) Importin alpha-7 subunit (Karyopherin alpha-6)
Length = 536
Score = 425 bits (1092), Expect = e-118
Identities = 241/464 (51%), Positives = 305/464 (64%), Gaps = 41/464 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQSG-VVPRFVQFLDKGDFPQLQLE 58
MV ++SDD+ QL T +FRK LS + PPID+VI + VV RFV+FL + + LQ E
Sbjct: 85 MVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFE 144
Query: 59 AAWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDL 118
AAWALTNIA+GTS+ TK+V++ GAVP+F++LL+S +DV+ QA WALGNIAGDS RD
Sbjct: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204
Query: 119 VLSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSK 177
VL+ L LL+ L + L RNAVW LSN CRGK P P +V LP L L+FS
Sbjct: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSS 264
Query: 178 DEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSG 237
D +L +ACWALSYLSDG ++ IQAVI++GVC RLV++L+ PALR VGNIV+G
Sbjct: 265 DSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTG 324
Query: 238 DDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLV 297
DD+QTQ I+N LPCLL LL+ PK+SI+KEAC T+SNITAGNR QIQAVI+A + L+
Sbjct: 325 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLI 384
Query: 298 NLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEG 357
+LQ AEF KE A A+TN TSGGT E I+YLVS GCIKPLCDLL D +IV V L G
Sbjct: 385 EILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNG 444
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
LEN L++GE E S +G VN Y I++ G
Sbjct: 445 LENILRLGEQEGKRSGSG-VNPYCGLIEEAYG---------------------------- 475
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYW-LEDEDETL 460
L+KIE L SHE++EIY+KA ++E Y+ +ED+D +L
Sbjct: 476 --------LDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSL 511
>IMA5_HUMAN (O15131) Importin alpha-6 subunit (Karyopherin alpha-5
subunit)
Length = 536
Score = 420 bits (1080), Expect = e-117
Identities = 239/461 (51%), Positives = 299/461 (64%), Gaps = 40/461 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQS-GVVPRFVQFLDKGDFPQLQLE 58
MV I+S++ QQL AT +FRK LS + PPID VIQ GVV RFV+FL++ + LQ E
Sbjct: 85 MVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFE 144
Query: 59 AAWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDL 118
AAWALTNIA+GT +TKVV++ GAVP+F+KLL+S +DV+ QA WALGNIAGD+ RD
Sbjct: 145 AAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDF 204
Query: 119 VLSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSK 177
VL+ L LL L L RNAVW LSN CRGK P P +V L L L+FS
Sbjct: 205 VLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSS 264
Query: 178 DEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSG 237
D VL + CWALSYLSDG +D IQAVI++GVC RLV++L+ + PALR VGNIV+G
Sbjct: 265 DPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTG 324
Query: 238 DDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLV 297
DD+QTQ I+N LPCLL LL+ PK+SI+KEAC T+SNITAGNR QIQAVI+A + L+
Sbjct: 325 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLI 384
Query: 298 NLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEG 357
+LQ AEF KE A A+TN TSGGT E I+YLV+ GCIKPLCDLL D +IV V L G
Sbjct: 385 EILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNG 444
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
LEN L++GE E + G +N Y I+
Sbjct: 445 LENILRLGEQESKQNGIG-INPYCALIE-------------------------------- 471
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
+ GL+KIE L SHE++EIY+KA ++E Y+ +ED+
Sbjct: 472 ----EAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDD 508
>IMA1_HUMAN (P52294) Importin alpha-1 subunit (Karyopherin alpha-1
subunit) (SRP1-beta) (RAG cohort protein 2)
(Nucleoprotein interactor 1) (NPI-1)
Length = 538
Score = 410 bits (1055), Expect = e-114
Identities = 236/464 (50%), Positives = 295/464 (62%), Gaps = 41/464 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQS-GVVPRFVQFLDKGDFPQLQLE 58
M+ I+S QQL AT +FRK LS + PPID+VI + GVV RFV+FL + + LQ E
Sbjct: 87 MIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFE 146
Query: 59 AAWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDL 118
+AW LTNIA+G S T++V+ GAVP+F++LLSS +DV+ QA WALGNIAGDS RD
Sbjct: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206
Query: 119 VLSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSK 177
VL L LL ++Q L RNAVW LSN CRGK P P +V L L L+F
Sbjct: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
Query: 178 DEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSG 237
D VL +ACWALSYLSDG +D IQAVI+AGVC RLV++L+ + PALR VGNIV+G
Sbjct: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTG 326
Query: 238 DDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLV 297
DD+QTQ I+N L LL LL+ PK+SIKKEAC T+SNITAGNR QIQ VI+A + L+
Sbjct: 327 DDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALI 386
Query: 298 NLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEG 357
++LQ AEF KE A A+TN TSGG+ E IKYLV GCIKPLCDLL D +IV V L G
Sbjct: 387 SILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNG 446
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
LEN L++GE E + TG +N Y I+
Sbjct: 447 LENILRLGEQEAKRNGTG-INPYCALIE-------------------------------- 473
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYW-LEDEDETL 460
+ GL+KIE L SHE++EIY+KA ++E Y+ EDED ++
Sbjct: 474 ----EAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSI 513
>IMA1_RAT (P83953) Importin alpha-1 subunit (Karyopherin alpha-1
subunit) (Importin alpha 5)
Length = 538
Score = 409 bits (1050), Expect = e-113
Identities = 235/464 (50%), Positives = 295/464 (62%), Gaps = 41/464 (8%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQS-GVVPRFVQFLDKGDFPQLQLE 58
M I+S+ QQL AT +FRK LS + PPID+VI + GVV RFV+FL + + LQ E
Sbjct: 87 MTEMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFE 146
Query: 59 AAWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDL 118
+AW LTNIA+G S T++V+ GAVP+F++LLSS +DV+ QA WALGNIAGDS RD
Sbjct: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206
Query: 119 VLSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSK 177
VL L LL ++Q L RNAVW LSN CRGK P P +V L L L+F
Sbjct: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
Query: 178 DEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSG 237
D VL +ACWALSYLSDG +D IQAVI+AGVC RLV++L+ + PALR VGNIV+G
Sbjct: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTG 326
Query: 238 DDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLV 297
DD+QTQ I+N L LL LL+ PK+SIKKEAC T+SNITAGNR QIQ VI+A + L+
Sbjct: 327 DDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALI 386
Query: 298 NLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEG 357
++LQ AEF KE A A+TN TSGG+ E IKYLV GCIKPLCDLL D +IV V L G
Sbjct: 387 SILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNG 446
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
LEN L++GE E + +G +N Y I+
Sbjct: 447 LENILRLGEQEAKRNGSG-INPYCALIE-------------------------------- 473
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYW-LEDEDETL 460
+ GL+KIE L SHE++EIY+KA ++E Y+ EDED ++
Sbjct: 474 ----EAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSI 513
>IMA1_MOUSE (Q60960) Importin alpha-1 subunit (Karyopherin alpha-1
subunit) (SRP1-beta) (RAG cohort protein 2)
(Nucleoprotein interactor 1) (Importin alpha S1)
Length = 538
Score = 406 bits (1044), Expect = e-113
Identities = 234/460 (50%), Positives = 294/460 (63%), Gaps = 41/460 (8%)
Query: 5 IWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQS-GVVPRFVQFLDKGDFPQLQLEAAWA 62
I+S+ QQL AT +FRK LS + PPID+VI + GVV RFV+FL + + LQ E+AW
Sbjct: 91 IFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWV 150
Query: 63 LTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSH 122
LTNIA+G S T+ V+ GAVP+F++LLSS +DV+ QA WALGNIAGDS RD VL+
Sbjct: 151 LTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNC 210
Query: 123 GALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVV 181
L LL ++Q L RNAVW LSN CRGK P P +V L L L+F D V
Sbjct: 211 NILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDV 270
Query: 182 LTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQ 241
L +ACWALSYLSDG +D IQAVI+AGVC RLV++L+ + PALR VGNIV+GDD+Q
Sbjct: 271 LADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQ 330
Query: 242 TQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQ 301
TQ I+N L LL LL+ PK+SIKKEAC T+SNITAGNR QIQ VI+A + L+++LQ
Sbjct: 331 TQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQ 390
Query: 302 NAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLENF 361
AEF KE A A+TN TSGG+ E IKYLV GCIKPLCDLL D +IV V L GLEN
Sbjct: 391 TAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENI 450
Query: 362 LKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMIE 421
L++GE E + +G +N Y I+
Sbjct: 451 LRLGEQEAKRNGSG-INPYCALIE------------------------------------ 473
Query: 422 DVKGLEKIENLDSHEDREIYEKAAKILERYW-LEDEDETL 460
+ GL+KIE L SHE++EIY+KA ++E Y+ EDED ++
Sbjct: 474 EAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSI 513
>IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha
subunit) (Serine-rich RNA polymerase I suppressor
protein)
Length = 542
Score = 399 bits (1024), Expect = e-110
Identities = 219/457 (47%), Positives = 294/457 (63%), Gaps = 42/457 (9%)
Query: 5 IWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQSGVVPRFVQFLDKGDFPQLQLEAAWAL 63
++SDD Q++AT +FRK LS + PPI VI +GVVPRFV+FL + L+ EA+WAL
Sbjct: 87 LYSDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFLSHEN-NLLKFEASWAL 145
Query: 64 TNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSHG 123
TN+A+G+S T VVV+ AVP+FV LLSS DVR QA WALGNIAGDSP RD VL G
Sbjct: 146 TNVASGSSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCG 205
Query: 124 ALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVVL 182
L LL+ + L LRN+ WTLSN CRGK PQP + +P L L+++ DE VL
Sbjct: 206 VLEPLLNIIESNRRLSMLRNSTWTLSNMCRGKNPQPDWNSISQVIPVLSKLIYTLDEDVL 265
Query: 183 TEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQT 242
+A WA+SYLSDG ++ IQA+I+AG+ RLV++L+ PS PALR+VGNIV+GDD+QT
Sbjct: 266 VDALWAISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVTGDDVQT 325
Query: 243 QAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQN 302
Q I+N G L LLSLL+ P+ ++KEAC T+SNITAGN QIQ VIEA +I PL++LL
Sbjct: 326 QVIINCGALSALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTT 385
Query: 303 AEFDITKEVAQALTNVTSGGTH--EHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLEN 360
A+F I KE A++N TSGG + I+YLV QG IKPLC+LL C D +I+ V L+G+EN
Sbjct: 386 ADFKIQKEACWAISNATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIEN 445
Query: 361 FLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMI 420
L+VGE +++ +N +NLYA +
Sbjct: 446 ILRVGELDRA-NNPDKINLYA------------------------------------VYV 468
Query: 421 EDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDED 457
ED G++ I + + EIY+KA I+E+++ E+++
Sbjct: 469 EDAGGMDLIHECQNSSNSEIYQKAYNIIEKFFGEEDE 505
>IMA1_YEAST (Q02821) Importin alpha subunit (Karyopherin alpha
subunit) (Serine-rich RNA polymerase I suppressor
protein)
Length = 542
Score = 398 bits (1022), Expect = e-110
Identities = 231/461 (50%), Positives = 294/461 (63%), Gaps = 42/461 (9%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVD-KPPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
M + SDD +QL AT +FR+ LS + +PPID VIQ+GVVPR V+F+ + LQLEA
Sbjct: 92 MTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEA 151
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTS TKVVVD AVP+F++LL + +V+ QA WALGN+AGDS RD V
Sbjct: 152 AWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYV 211
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKD 178
L A+ +L N + +R A WTLSN CRGK PQP V ALP L L++S D
Sbjct: 212 LQCNAMEPILGLFNSNKPSL-IRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMD 270
Query: 179 EVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGD 238
L +ACWA+SYLSDG + IQAVI+ + RLV++L S PALR VGNIV+G+
Sbjct: 271 TETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGN 330
Query: 239 DMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
D+QTQ ++N G+LP L LL+ PK++IKKEAC T+SNITAGN EQIQAVI+A LI PLV
Sbjct: 331 DLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVK 390
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTH--EHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLE 356
LL+ AE+ KE A++N +SGG + I+YLVSQGCIKPLCDLL D RI+ V L+
Sbjct: 391 LLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLD 450
Query: 357 GLENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLY 416
LEN LK+GEA+ K+ GL ++N
Sbjct: 451 ALENILKMGEAD----------------KEARGL---------------------NINEN 473
Query: 417 AQMIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDED 457
A IE G+EKI N +E+ +IYEKA KI+E Y+ E+ED
Sbjct: 474 ADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEED 514
>IMA2_MOUSE (P52293) Importin alpha-2 subunit (Karyopherin alpha-2
subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin)
(Pore targeting complex 58 kDa subunit) (PTAC58)
(Importin alpha P1)
Length = 529
Score = 351 bits (900), Expect = 3e-96
Identities = 203/464 (43%), Positives = 278/464 (59%), Gaps = 48/464 (10%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
+V I S++ QL+AT RK LS +K PPID++I++G++P+FV FL K D +Q E+
Sbjct: 81 IVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFES 140
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSE TK VVD GA+P F+ LL+SP + QA WALGNIAGD RDLV
Sbjct: 141 AWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLV 200
Query: 120 LSHGALILLLSQLNEQE----GLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLV 174
+ HGA+ LL+ L + LRN WTLSN CR K P P L+ V LP L L+
Sbjct: 201 IKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLL 260
Query: 175 FSKDEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNI 234
D VL ++CWA+SYL+DG ++ I+ V++ GV +LV++L L + PALR +GNI
Sbjct: 261 HHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI 320
Query: 235 VSGDDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIA 294
V+G D QTQ +++ G L SLLT+PK +I+KEA T+SNITAG ++QIQ V+ GL+
Sbjct: 321 VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
Query: 295 PLVNLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVC 354
LV +L A+F KE A A+TN TSGGT E I YLV G I+PL +LL D +I+ V
Sbjct: 381 FLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVI 440
Query: 355 LEGLENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVN 414
L+ + N + E K+GE EK
Sbjct: 441 LDAISNIFQAAE--------------------------------KLGETEK--------- 459
Query: 415 LYAQMIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
+ MIE+ GL+KIE L HE+ +Y+ + ++E+Y+ +E+E
Sbjct: 460 -LSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEE 502
>IMA2_XENLA (P52171) Importin alpha-2 subunit (Karyopherin alpha-2
subunit)
Length = 522
Score = 348 bits (893), Expect = 2e-95
Identities = 193/458 (42%), Positives = 273/458 (59%), Gaps = 44/458 (9%)
Query: 7 SDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEAAWALTN 65
S DN +L +T RK LS ++ PP++D+I++G++P+ V+FL + LQ EAAWALTN
Sbjct: 83 SGDNENELRSTQAARKMLSKERNPPLNDIIEAGLIPKLVEFLSYHNNSTLQFEAAWALTN 142
Query: 66 IAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSHGAL 125
IA+GTS+ TK VVD GA+P F+ L+SSP + QA WALGNIAGD P RD ++S +
Sbjct: 143 IASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLYRDALISCNVI 202
Query: 126 ILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVVLTE 184
LL+ +N Q L LRN WTLSN CR K P P + V LP L L+ +D+ +L++
Sbjct: 203 PPLLTLVNPQTPLGYLRNITWTLSNLCRNKNPYPPMSAVLQILPVLTQLMLHEDKDILSD 262
Query: 185 ACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQTQA 244
CWA+SYL+DG++D I V++ G+ RL+Q++ P LS L P+LRTVGNIV+G D QTQA
Sbjct: 263 TCWAMSYLTDGSNDRIDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNIVTGTDKQTQA 322
Query: 245 IVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQNAE 304
++ G+L L LL H K SI+KEA LSNI AG QIQ +I GL++PLV+LL+ +
Sbjct: 323 AIDAGVLSVLPQLLRHQKPSIQKEAAWALSNIAAGPAPQIQQMITCGLLSPLVDLLKKGD 382
Query: 305 FDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLENFLKV 364
F KE A+TN TSGGT E + LV G ++PL +LL D + + V L+ + N
Sbjct: 383 FKAQKEAVWAVTNYTSGGTVEQVVQLVQCGVLEPLLNLLTIKDSKTILVILDAISNIFLA 442
Query: 365 GEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMIEDVK 424
E K+GE EK ++E++
Sbjct: 443 AE--------------------------------KLGEQEK----------LCLLVEELG 460
Query: 425 GLEKIENLDSHEDREIYEKAAKILERYWLEDEDETLTS 462
GLEKIE L +H++R +Y A ++E+Y+ +E + + +
Sbjct: 461 GLEKIEALQTHDNRMVYHAALALIEKYFSGEEADEMNA 498
>IMA2_HUMAN (P52292) Importin alpha-2 subunit (Karyopherin alpha-2
subunit) (SRP1-alpha) (RAG cohort protein 1)
Length = 529
Score = 343 bits (881), Expect = 4e-94
Identities = 199/464 (42%), Positives = 276/464 (58%), Gaps = 48/464 (10%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
+V I S + QL+AT RK LS +K PPID++I++G++P+FV FL + D +Q E+
Sbjct: 81 IVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFES 140
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSE TK VVD GA+P F+ LL+SP + QA WALGNIAGD RDLV
Sbjct: 141 AWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLV 200
Query: 120 LSHGALILLLSQLNEQE----GLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLV 174
+ +GA+ LL+ L + LRN WTLSN CR K P P ++ V LP L L+
Sbjct: 201 IKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLL 260
Query: 175 FSKDEVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNI 234
D VL + CWA+SYL+DG ++ I V++ GV +LV++L L + PALR +GNI
Sbjct: 261 HHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNI 320
Query: 235 VSGDDMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIA 294
V+G D QTQ +++ G L SLLT+PK +I+KEA T+SNITAG ++QIQ V+ GL+
Sbjct: 321 VTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
Query: 295 PLVNLLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVC 354
LV++L A+F KE A+TN TSGGT E I YLV G I+PL +LL D +I+ V
Sbjct: 381 FLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVI 440
Query: 355 LEGLENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVN 414
L+ + N + E K+GE EK
Sbjct: 441 LDAISNIFQAAE--------------------------------KLGETEK--------- 459
Query: 415 LYAQMIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
+ MIE+ GL+KIE L +HE+ +Y+ + ++E+Y+ +E+E
Sbjct: 460 -LSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEE 502
>IMA1_XENLA (P52170) Importin alpha-1 subunit (Karyopherin alpha-1
subunit)
Length = 521
Score = 340 bits (871), Expect = 6e-93
Identities = 188/456 (41%), Positives = 267/456 (58%), Gaps = 44/456 (9%)
Query: 7 SDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEAAWALTN 65
S D +L T RK LS ++ PP++D+I++G++P+ V+FL + D LQ EAAWALTN
Sbjct: 83 SGDPENELRCTQAARKMLSRERNPPLNDIIEAGLIPKLVEFLSRHDNSTLQFEAAWALTN 142
Query: 66 IAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSHGAL 125
IA+GTS+ TK VVD GA+P F+ L+SSP + QA WALGNIAGD P RD +++ +
Sbjct: 143 IASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLYRDALINCNVI 202
Query: 126 ILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVVLTE 184
LL+ +N Q L LRN W LSN CR K P P + V LP L L+ D+ +L++
Sbjct: 203 PPLLALVNPQTPLGYLRNITWMLSNLCRNKNPYPPMSAVLQILPVLTQLMHHDDKDILSD 262
Query: 185 ACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQTQA 244
CWA+SYL+DG++D I V++ G+ RL+Q++ P LS + P+LRTVGNIV+G D QTQA
Sbjct: 263 TCWAMSYLTDGSNDRIDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNIVTGTDKQTQA 322
Query: 245 IVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQNAE 304
++ G+L L LL H K SI+KEA +SNI AG QIQ +I GL++PLV+LL +
Sbjct: 323 AIDAGVLSVLPQLLRHQKPSIQKEAAWAISNIAAGPAPQIQQMITCGLLSPLVDLLNKGD 382
Query: 305 FDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLENFLKV 364
F KE A+TN TSGGT E + LV G ++PL +LL D + + V L+ + N
Sbjct: 383 FKAQKEAVWAVTNYTSGGTVEQVVQLVQCGVLEPLLNLLTIKDSKTILVILDAISNIFLA 442
Query: 365 GEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMIEDVK 424
E K+GE EK ++E++
Sbjct: 443 AE--------------------------------KLGEQEK----------LCLLVEELG 460
Query: 425 GLEKIENLDSHEDREIYEKAAKILERYWLEDEDETL 460
GLEKIE L +H++ +Y A ++E+Y+ +E + +
Sbjct: 461 GLEKIEALQTHDNHMVYHAALALIEKYFSGEEADDI 496
>IMA4_MOUSE (O35343) Importin alpha-4 subunit (Karyopherin alpha-4
subunit) (Importin alpha Q1)
Length = 521
Score = 336 bits (861), Expect = 9e-92
Identities = 192/458 (41%), Positives = 269/458 (57%), Gaps = 46/458 (10%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
+V + SD+ QL A RK LS D+ PPIDD+I+SG++P V L++ D P LQ EA
Sbjct: 76 IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEA 135
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSE T+ VV AVP+F++LL SP +V QA WALGNI GD P+ RD V
Sbjct: 136 AWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYV 195
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKD 178
+S G + LLS ++ + LRN W + N CR K P P +E ++ LPAL L+ D
Sbjct: 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTD 255
Query: 179 EVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGD 238
+L + WALSYL+D ++ IQ VI++G+ LV +L + ALR VGNIV+G
Sbjct: 256 VNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGT 315
Query: 239 DMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
D QTQ ++N L +LLTHPK+ I KEA LSNITAGN++Q+QAVI+A L+ +++
Sbjct: 316 DEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIH 375
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 358
LL +F KE A A++N+T G + + YL+ Q I P C+LL D ++V V L+GL
Sbjct: 376 LLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGL 435
Query: 359 ENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQ 418
N LK+ E + A+TI A
Sbjct: 436 SNILKMAEDQ------------AETI--------------------------------AN 451
Query: 419 MIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDE 456
+IE+ GLEKIE L +HE+ +IY+ A +I+++++ D+
Sbjct: 452 LIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDD 489
>IMA4_HUMAN (O00629) Importin alpha-4 subunit (Karyopherin alpha-4
subunit) (Qip1 protein)
Length = 521
Score = 336 bits (861), Expect = 9e-92
Identities = 194/458 (42%), Positives = 270/458 (58%), Gaps = 46/458 (10%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
+V + SD+ QL A RK LS D+ PPIDD+I+SG++P V L++ D P LQ EA
Sbjct: 76 IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEA 135
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTSE T+ VV AVP+F++LL SP +V QA WALGNI GD P+ RD V
Sbjct: 136 AWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYV 195
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKD 178
+S G + LLS ++ + LRN W + N CR K P P +E ++ LPAL L+ D
Sbjct: 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTD 255
Query: 179 EVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGD 238
+L + WALSYL+D ++ IQ VI++G+ LV +L + ALR VGNIV+G
Sbjct: 256 VNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGT 315
Query: 239 DMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
D QTQ ++N L +LLTHPK+ I KEA LSNITAGN++Q+QAVI+A L+ +++
Sbjct: 316 DEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIH 375
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGL 358
LL +F KE A A++N+T G + + YL+ Q I P C+LL D ++V V L+GL
Sbjct: 376 LLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGL 435
Query: 359 ENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQ 418
N LK+ E E A+TI GN
Sbjct: 436 SNILKMAEDE------------AETI-----------------------GN--------- 451
Query: 419 MIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDE 456
+IE+ GLEKIE L +HE+ +IY+ A +I+++++ D+
Sbjct: 452 LIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDD 489
>IMA3_MOUSE (O35344) Importin alpha-3 subunit (Karyopherin alpha-3
subunit) (Importin alpha Q2)
Length = 521
Score = 332 bits (852), Expect = 1e-90
Identities = 195/452 (43%), Positives = 268/452 (59%), Gaps = 46/452 (10%)
Query: 7 SDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEAAWALTN 65
SD+ QL A RK LS D+ PPIDD+I+SG++P V+ L++ D P LQ EAAWALTN
Sbjct: 82 SDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTN 141
Query: 66 IAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSHGAL 125
IA+GTS T+ VV AVP+F++LL SP +V QA WALGNI GD P+ RD V+S G +
Sbjct: 142 IASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVV 201
Query: 126 ILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVVLTE 184
LLS +N + LRN W + N CR K P P +E V+ LPAL L++ D +L +
Sbjct: 202 KPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVD 261
Query: 185 ACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQTQA 244
WALSYL+DG ++ IQ VI++GV LV +L + ALR VGNIV+G D QTQ
Sbjct: 262 TVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV 321
Query: 245 IVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQNAE 304
++N +L +LL+HPK+ I KEA LSNITAGN++Q+QAVI+AGLI +++ L +
Sbjct: 322 VLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGD 381
Query: 305 FDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLENFLKV 364
F KE A A++N+T G + ++YLV Q I P C+LL D ++V V L+GL+N L +
Sbjct: 382 FGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIM 441
Query: 365 GEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMIEDVK 424
E A TI A++IE+
Sbjct: 442 AGDE------------ASTI--------------------------------AEIIEECG 457
Query: 425 GLEKIENLDSHEDREIYEKAAKILERYWLEDE 456
GLEKIE L HE+ +IY+ A +I+++Y+ D+
Sbjct: 458 GLEKIEVLQQHENEDIYKLAFEIIDQYFSGDD 489
>IMA3_HUMAN (O00505) Importin alpha-3 subunit (Karyopherin alpha-3
subunit) (SRP1-gamma)
Length = 521
Score = 330 bits (847), Expect = 4e-90
Identities = 194/452 (42%), Positives = 268/452 (58%), Gaps = 46/452 (10%)
Query: 7 SDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEAAWALTN 65
SD+ QL A RK LS D+ PPIDD+I+SG++P V+ L++ D P LQ EAAWALTN
Sbjct: 82 SDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTN 141
Query: 66 IAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLVLSHGAL 125
IA+GTS T+ VV AVP+F++LL SP +V QA WALGNI GD P+ RD V+S G +
Sbjct: 142 IASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVV 201
Query: 126 ILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKDEVVLTE 184
LLS ++ + LRN W + N CR K P P +E V+ LPAL L++ D +L +
Sbjct: 202 KPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVD 261
Query: 185 ACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGDDMQTQA 244
WALSYL+DG ++ IQ VI++GV LV +L + ALR VGNIV+G D QTQ
Sbjct: 262 TVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV 321
Query: 245 IVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVNLLQNAE 304
++N +L +LL+HPK+ I KEA LSNITAGN++Q+QAVI+AGLI +++ L +
Sbjct: 322 VLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGD 381
Query: 305 FDITKEVAQALTNVTSGGTHEHIKYLVSQGCIKPLCDLLVCPDPRIVTVCLEGLENFLKV 364
F KE A A++N+T G + ++YLV Q I P C+LL D ++V V L+GL+N L +
Sbjct: 382 FGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIM 441
Query: 365 GEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYAQMIEDVK 424
E A TI A++IE+
Sbjct: 442 AGDE------------ASTI--------------------------------AEIIEECG 457
Query: 425 GLEKIENLDSHEDREIYEKAAKILERYWLEDE 456
GLEKIE L HE+ +IY+ A +I+++Y+ D+
Sbjct: 458 GLEKIEVLQQHENEDIYKLAFEIIDQYFSGDD 489
>IMA_DROME (P52295) Importin alpha subunit (Karyopherin alpha
subunit) (Pendulin)
Length = 522
Score = 324 bits (831), Expect = 3e-88
Identities = 191/461 (41%), Positives = 265/461 (57%), Gaps = 45/461 (9%)
Query: 1 MVADIWSDDNSQQLEATTEFRKRLSVDK-PPIDDVIQSGVVPRFVQFLDKGDFPQLQLEA 59
+VA + S+D +Q RK LS ++ PPID +I G+VP ++FL + LQ EA
Sbjct: 74 IVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEA 133
Query: 60 AWALTNIAAGTSENTKVVVDHGAVPMFVKLLSSPCDDVRGQAAWALGNIAGDSPRGRDLV 119
AWALTNIA+GTS+ T+ V++H AVP FV LL S ++ QA WALGNIAGD RD+V
Sbjct: 134 AWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIV 193
Query: 120 LSHGALILLLSQLNEQEGLYRLRNAVWTLSNFCRGK-PQPALEQVRSALPALKCLVFSKD 178
+ H + +L +N + L LRN VW +SN CR K P P +QV+ LP L L+ S+D
Sbjct: 194 IHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQD 253
Query: 179 EVVLTEACWALSYLSDGTSDNIQAVIEAGVCGRLVQILLEPSLSALFPALRTVGNIVSGD 238
VL +ACWALSY++D + IQAV+++ RLV++L S + PALR+VGNIV+G
Sbjct: 254 IQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGT 313
Query: 239 DMQTQAIVNHGLLPCLLSLLTHPKKSIKKEACRTLSNITAGNREQIQAVIEAGLIAPLVN 298
D QT ++ G LP L LL H K +I KEA T+SNITAGN++QIQAVI+AG+ L
Sbjct: 314 DQQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRT 373
Query: 299 LLQNAEFDITKEVAQALTNVTSGGTHEHIKYLVSQ-GCIKPLCDLLVCPDPRIVTVCLEG 357
+L+ +F KE A A+TN T+ GT E I L+ + +KP DLL DPR + V G
Sbjct: 374 VLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTG 433
Query: 358 LENFLKVGEAEKSISNTGDVNLYAQTIKDVEGLEKGLEKFLKVGEAEKRFGNTGDVNLYA 417
L N + E + G T ++ L
Sbjct: 434 LSNLFALAE---------------------------------------KLGGTENLCL-- 452
Query: 418 QMIEDVKGLEKIENLDSHEDREIYEKAAKILERYWLEDEDE 458
M+E++ GL+K+E L HE+ E+Y+KA I++ Y+ +DE
Sbjct: 453 -MVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDE 492
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.317 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,688,531
Number of Sequences: 164201
Number of extensions: 2229856
Number of successful extensions: 6545
Number of sequences better than 10.0: 76
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5998
Number of HSP's gapped (non-prelim): 150
length of query: 466
length of database: 59,974,054
effective HSP length: 114
effective length of query: 352
effective length of database: 41,255,140
effective search space: 14521809280
effective search space used: 14521809280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Medicago: description of AC122160.6