BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC121234.10 + phase: 0 
         (526 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

S225_MOUSE (Q9Z0E8) Organic cation/carnitine transporter 2 (Solu...   173  9e-43
S225_RAT (O70594) Organic cation/carnitine transporter 2 (Solute...   172  2e-42
S229_MOUSE (Q9WTN6) Organic cation/carnitine transporter 3 (Solu...   169  2e-41
S225_HUMAN (O76082) Organic cation/carnitine transporter 2 (Solu...   168  4e-41
S224_HUMAN (Q9H015) Organic cation/carnitine transporter 1 (Solu...   166  1e-40
S223_RAT (O88446) Organic cation transporter 3 (Solute carrier f...   164  4e-40
S223_MOUSE (Q9WTW5) Organic cation transporter 3 (Solute carrier...   163  9e-40
S224_MOUSE (Q9Z306) Organic cation/carnitine transporter 1 (Solu...   162  3e-39
S224_RAT (Q9R141) Organic cation/carnitine transporter 1 (Solute...   159  2e-38
S223_HUMAN (O75751) Organic cation transporter 3 (Extraneuronal ...   158  4e-38
ORCT_DROME (Q9VCA2) Organic cation transporter protein                131  4e-30
OCTL_DROME (Q95R48) Organic cation transporter-like protein           120  9e-27
OCT1_CAEEL (Q9U539) Organic cation transporter 1 (CeOCT1)             114  8e-25
YT13_CAEEL (Q10917) Hypothetical protein B0252.3 in chromosome II      88  6e-17
HXT3_YEAST (P32466) Low-affinity glucose transporter HXT3              82  4e-15
HXT1_YEAST (P32465) Low-affinity glucose transporter HXT1              78  6e-14
YFIG_BACSU (P54723) Hypothetical metabolite transport protein yfiG     77  8e-14
HXT5_YEAST (P38695) Probable glucose transporter HXT5                  74  1e-12
YAAU_ECOLI (P31679) Hypothetical metabolite transport protein yaaU     70  1e-11
HXTG_YEAST (P53631) Hexose transporter HXT17                           70  1e-11

>S225_MOUSE (Q9Z0E8) Organic cation/carnitine transporter 2 (Solute
           carrier family 22, member 5) (High-affinity
           sodium-dependent carnitine cotransporter)
          Length = 557

 Score =  173 bits (439), Expect = 9e-43
 Identities = 130/423 (30%), Positives = 208/423 (48%), Gaps = 27/423 (6%)

Query: 92  WSWDTHPS-NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIF 150
           W +D     +TI++ W+L C   +   L  S FF+G L+GSF    L+D   GRKN+L  
Sbjct: 117 WEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDR-FGRKNVLFL 175

Query: 151 SCVSMSITSMLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRF---RVGI 207
           +    +  S L +FS N  +++ L  L+G  + S      VL TE +S   R     +G+
Sbjct: 176 TMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGV 235

Query: 208 VEYFTFTMGYMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGRE 267
             ++ F  G+M LP FAY  R+  W+ L +  +VP +    + + F+ ESPRWL+ QGR 
Sbjct: 236 CIFYAF--GFMVLPLFAYFIRD--WRMLLLALTVPGVLCGAL-WWFIPESPRWLISQGRI 290

Query: 268 KEILKMLKRVSSEESADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFHK----RWAVI 323
           KE   ++++ +           + +   I  P E      L S+  +L H     R   I
Sbjct: 291 KEAEVIIRKAAKING-------IVAPSTIFDPSE---LQDLNSTKPQLHHIYDLIRTRNI 340

Query: 324 RMIAVM--ILGIGLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRK 380
           R+I +M  IL + + + YFG+ L   NL  +IY+     A++E+P+ V  + L + L R+
Sbjct: 341 RVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRR 400

Query: 381 PSILVFSILGGICCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRN 440
            SI     LGG   +   ++ + +      L MV  FG  +AY++  +Y  EL+PT VRN
Sbjct: 401 YSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRN 460

Query: 441 TTTSLVRQAIVFGCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDT 500
               +   A   G I  P+ +  G  +    Y + G + +L+     F PE+ G+ L DT
Sbjct: 461 MGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDT 520

Query: 501 MDQ 503
           +DQ
Sbjct: 521 IDQ 523


>S225_RAT (O70594) Organic cation/carnitine transporter 2 (Solute
           carrier family 22, member 5) (High-affinity
           sodium-dependent carnitine cotransporter) (UST2r) (CT1)
          Length = 557

 Score =  172 bits (436), Expect = 2e-42
 Identities = 131/430 (30%), Positives = 211/430 (48%), Gaps = 20/430 (4%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +TI++ W+L C   +   L  S FF+G L+GSF    L+D   GRKN+L  +    +  S
Sbjct: 126 STIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDR-FGRKNVLFLTMGMQTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRF---RVGIVEYFTFTMG 216
            L +FS N  +++ L  L+G  + S      VL TE +S   R     +G+  ++ F  G
Sbjct: 185 FLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAF--G 242

Query: 217 YMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKR 276
           +M LP FAY  R+  W+ L +  +VP +    + + F+ ESPRWL+ QGR KE   ++++
Sbjct: 243 FMVLPLFAYFIRD--WRMLLLALTVPGVLCGAL-WWFIPESPRWLISQGRVKEAEVIIRK 299

Query: 277 VSSEESADDDSVNL-ASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVM--ILGI 333
            +        S     S L  L  K+  S   +Y  +      R   IR+I +M  IL +
Sbjct: 300 AAKFNGIVAPSTIFDPSELQDLNSKKPQSH-HIYDLV------RTRNIRIITIMSIILWL 352

Query: 334 GLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSILGGI 392
            + + YFG+ L   NL  +IY+     A++E+P+ V  + L ++L R+ SI     LGG 
Sbjct: 353 TISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGS 412

Query: 393 CCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVF 452
             +   ++ + +      L MV  FG  +AY++  +Y  EL+PT VRN    +   A   
Sbjct: 413 VLLFIQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRL 472

Query: 453 GCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEKKEIALC 512
           G I  P+ +  G  +    Y + G + +L+     F PE+ G  L DT+DQ  + +    
Sbjct: 473 GSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGAPLPDTIDQMLRVKGIKQ 532

Query: 513 DAMNQQVRTE 522
             +  Q RT+
Sbjct: 533 WQIQSQTRTQ 542


>S229_MOUSE (Q9WTN6) Organic cation/carnitine transporter 3 (Solute
           carrier family 22, member 9)
          Length = 564

 Score =  169 bits (428), Expect = 2e-41
 Identities = 122/417 (29%), Positives = 203/417 (48%), Gaps = 23/417 (5%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +TI++ W+L C   +   L  S F++G LLGSF    L+D   GRKN+L  +    +  S
Sbjct: 126 STIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDR-FGRKNILFLTMAMHTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRF---RVGIVEYFTFTMG 216
            + +FS N  +++ L  L+G    S      VL TE +S   R     +G+  +F F  G
Sbjct: 185 FIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAF--G 242

Query: 217 YMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKR 276
           +M LP FAY  R   W+ L +  ++P +    + + F+ ESPRWL+ QGR KE   ++++
Sbjct: 243 FMVLPLFAYFIRE--WRRLLLAITLPGVLCGAL-WWFIPESPRWLISQGRIKEAEVIIRK 299

Query: 277 VSSEESADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFH----KRWAVIRMIAVM--I 330
            +           + +   I  P E        S   +  H     R   IR++ +M  I
Sbjct: 300 AAKING-------IVAPSTIFDPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSII 352

Query: 331 LGIGLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSIL 389
           L + + + YFG+ L   NL  NIY+     A++E+P+ V  + L +++ R+ S+     L
Sbjct: 353 LWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFL 412

Query: 390 GGICCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQA 449
           GG   +   ++ + +      L MV  FG  +AY++  +Y  EL+PT VRN    +   A
Sbjct: 413 GGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTA 472

Query: 450 IVFGCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
              G I  P+ +  G  +    Y + G + +L+     F PE+ G+ L +T+D+ +K
Sbjct: 473 SRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDEMQK 529


>S225_HUMAN (O76082) Organic cation/carnitine transporter 2 (Solute
           carrier family 22, member 5) (High-affinity
           sodium-dependent carnitine cotransporter)
          Length = 557

 Score =  168 bits (425), Expect = 4e-41
 Identities = 130/411 (31%), Positives = 204/411 (49%), Gaps = 20/411 (4%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +TI++ WNL C   +   L  S FF+G LLGSF    L+D   GRKN+L  +    +  S
Sbjct: 126 STIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDR-FGRKNVLFVTMGMQTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRF---RVGIVEYFTFTMG 216
            L IFS N  ++  L  L+G  + S      VL TE +    R     +G+  ++ F  G
Sbjct: 185 FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF--G 242

Query: 217 YMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKR 276
           YM LP FAY  R+  W+ L +  ++P +   V  + F+ ESPRWL+ QGR +E   ++++
Sbjct: 243 YMVLPLFAYFIRD--WRMLLVALTMPGVL-CVALWWFIPESPRWLISQGRFEEAEVIIRK 299

Query: 277 VSSEESADDDSVNL-ASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVM--ILGI 333
            +        S     S L  L  K++ S      +I +L  + W  IRM+ +M  +L +
Sbjct: 300 AAKANGIVVPSTIFDPSELQDLSSKKQQSH-----NILDLL-RTWN-IRMVTIMSIMLWM 352

Query: 334 GLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSILGGI 392
            + + YFG+ L   NL  +I++    SA +E+P+ V  + L + L R+ S+     LGG 
Sbjct: 353 TISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGS 412

Query: 393 CCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVF 452
             +   ++   +     VL MV  FG   A+++  +Y  EL+PT VRN    +   A   
Sbjct: 413 VLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRL 472

Query: 453 GCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQ 503
           G I  P+ +  G  +    Y + G + +L+     FLPE+ G  L DT+DQ
Sbjct: 473 GSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 523


>S224_HUMAN (Q9H015) Organic cation/carnitine transporter 1 (Solute
           carrier family 22, member 4)
          Length = 551

 Score =  166 bits (420), Expect = 1e-40
 Identities = 119/409 (29%), Positives = 198/409 (48%), Gaps = 12/409 (2%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +T+++ WNL C   +   L  S FF+G LLGSF    L+D   GRKN+L  +    +  S
Sbjct: 126 STVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDR-FGRKNVLFATMAVQTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTF-TMGYM 218
            L IFS +  +++ L  ++G  + S      +L TE +    R     +   TF  +GYM
Sbjct: 185 FLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYM 244

Query: 219 SLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVS 278
            LP FAY  R+  W+ L +  +VP +   V  + F+ ESPRWL+ Q R +E   ++++ +
Sbjct: 245 LLPLFAYFIRD--WRMLLLALTVPGVL-CVPLWWFIPESPRWLISQRRFREAEDIIQKAA 301

Query: 279 SEESADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMV 338
              +    +V   S   + P K++ +F      I +LF  R   I  I  ++L +   + 
Sbjct: 302 KMNNTAVPAVIFDSVEELNPLKQQKAF------ILDLFRTRNIAIMTIMSLLLWMLTSVG 355

Query: 339 YFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSILGGICCVTC 397
           YF + L   NL  + YL    SA +E+P+ +  + L   L R+  I      GG   +  
Sbjct: 356 YFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFI 415

Query: 398 AVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFC 457
            ++        + L M+  FG  +A+++  ++  EL+PT VRN    +   A   G I  
Sbjct: 416 QLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIA 475

Query: 458 PFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
           P+ +  G  N +  Y V G + +L      F PE++G+ L +T++Q +K
Sbjct: 476 PYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQK 524


>S223_RAT (O88446) Organic cation transporter 3 (Solute carrier
           family 22, member 3)
          Length = 551

 Score =  164 bits (416), Expect = 4e-40
 Identities = 128/439 (29%), Positives = 217/439 (49%), Gaps = 26/439 (5%)

Query: 95  DTHPSNTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVS 154
           +TH  +TI+S ++L C + ++  L Q+   +G L G+F L   AD   GR  + + SC  
Sbjct: 130 ETH--STIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADR-YGRLIVYLISCFG 186

Query: 155 MSITSMLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFT 214
           + IT +++ F+ N  ++   +FL G +         V++TE V ++ R  VGIV    FT
Sbjct: 187 VGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFT 246

Query: 215 MGYMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKML 274
           +G + LPG AY     SW+ + +  S+P+  + ++ Y  V ESPRWL+ + + ++ L++L
Sbjct: 247 LGIIILPGIAYF--TPSWQGIQLAISLPSFLF-LLYYWVVPESPRWLITRKQGEKALQIL 303

Query: 275 KRVSSEESADDDSVNLASNL-PILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGI 333
           +RV     A  +  +L+SN   I    E+VS       +     ++  +I M A     +
Sbjct: 304 RRV-----AKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAV 358

Query: 334 GLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYF-LENLRRKPSILVFSILGGI 392
               VY G+ + +G +G N+Y+    S  +ELP  +     +E L R+      +I+ G+
Sbjct: 359 ----VYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGV 414

Query: 393 CCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVF 452
            C+  A L   +P  +  +A +   G   A+ +  +   EL+PT +RN   SL      F
Sbjct: 415 SCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDF 474

Query: 453 GCIFCPFLISAGRKNNIY---SYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK--- 506
           G I  PFL+   R   I+      +FG++  +    +  LPET GI L +T++  EK   
Sbjct: 475 GGIIAPFLLF--RLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGS 532

Query: 507 KEIALCDAMNQ-QVRTENV 524
            ++  C    + QV T NV
Sbjct: 533 SQLHQCGRKKKTQVSTSNV 551


>S223_MOUSE (Q9WTW5) Organic cation transporter 3 (Solute carrier
           family 22, member 3)
          Length = 551

 Score =  163 bits (413), Expect = 9e-40
 Identities = 122/417 (29%), Positives = 209/417 (49%), Gaps = 22/417 (5%)

Query: 95  DTHPSNTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVS 154
           +TH  +TI+S ++L C++ ++  L Q+   +G L G+F L   AD   GR  + + SC  
Sbjct: 130 ETH--STIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADR-YGRLIIYLISCFG 186

Query: 155 MSITSMLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFT 214
           + IT +++ F+ N  ++   +FL G +         V++TE V ++ R  VGIV    FT
Sbjct: 187 VGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFT 246

Query: 215 MGYMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKML 274
           +G + LPG AY     SW+ + +  S+P+  + ++ Y  V ESPRWL+ + + ++ L++L
Sbjct: 247 LGIIILPGIAYF--TPSWQGIQLAISLPSFLF-LLYYWVVPESPRWLITRKQGEKALQIL 303

Query: 275 KRVSSEESADDDSVNLASNL-PILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGI 333
           +RV     A  +  +L+SN   I    E+VS       +     ++  +I M A     +
Sbjct: 304 RRV-----AKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAV 358

Query: 334 GLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYF-LENLRRKPSILVFSILGGI 392
               VY G+ + +G +G N+Y+    S  +ELP  +     +E L R+      +I+ G+
Sbjct: 359 ----VYQGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGV 414

Query: 393 CCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVF 452
            C+  A L   +P  +  +A +   G   A+ +  +   EL+PT +RN   SL      F
Sbjct: 415 SCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDF 474

Query: 453 GCIFCPFLISAGRKNNIY---SYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
           G I  PFL+   R   I+      +FG++  +    +  LPET GI L +T++  EK
Sbjct: 475 GGIIAPFLLF--RLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEK 529


>S224_MOUSE (Q9Z306) Organic cation/carnitine transporter 1 (Solute
           carrier family 22, member 4)
          Length = 553

 Score =  162 bits (409), Expect = 3e-39
 Identities = 123/410 (30%), Positives = 198/410 (48%), Gaps = 12/410 (2%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +TI++ WNL C   + T L  S FF+G L GSF    L+D   GRK +L  +    +  S
Sbjct: 126 STIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDR-FGRKKVLFATMAVQTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTF-TMGYM 218
            + IFSTN  +++ L  ++G  + S      +L TE +S   R     +   TF  +GYM
Sbjct: 185 FVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYM 244

Query: 219 SLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVS 278
            LP FAY  R+  W+ L +  ++P + + V  + F+ ESPRWL+ Q R  E  +++++ +
Sbjct: 245 VLPLFAYFIRD--WRMLLLALTLPGL-FCVPLWWFIPESPRWLISQRRFAEAEQIIQKAA 301

Query: 279 SEESADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFHKR-WAVIRMIAVMILGIGLGM 337
              S     V  A     L  +E  S  Q    I +LF  R  A I ++AVM+  +   +
Sbjct: 302 KMNSI----VAPAGIFDPLELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWML-TSV 356

Query: 338 VYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSILGGICCVT 396
            YF + L V NL  ++YL    S  +E+P+    + L   L R+  I      GG   + 
Sbjct: 357 GYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLL 416

Query: 397 CAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIF 456
             V+        + L M+  FG  +A+++  ++  EL+PT VRN    +   A   G I 
Sbjct: 417 IQVVPEDYNFVSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSII 476

Query: 457 CPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
            P+ +  G  N +  Y + G + +L      F PE+ G+ L + ++Q +K
Sbjct: 477 APYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQK 526


>S224_RAT (Q9R141) Organic cation/carnitine transporter 1 (Solute
           carrier family 22, member 4)
          Length = 553

 Score =  159 bits (402), Expect = 2e-38
 Identities = 117/409 (28%), Positives = 194/409 (46%), Gaps = 10/409 (2%)

Query: 100 NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITS 159
           +TI++ WNL C   + T L  S FF+G L GSF    L+D   GRK +L  +    +  S
Sbjct: 126 STIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDR-FGRKKVLFATMAVQTGFS 184

Query: 160 MLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTF-TMGYM 218
            + IFSTN  +++ L  ++G  + S      +L TE +S   R     +   TF  +GYM
Sbjct: 185 FVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFFAIGYM 244

Query: 219 SLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVS 278
            LP FAY  R+  W+ L +  ++P + + V  + F+ ESPRWL+ Q R +E  +++++ +
Sbjct: 245 VLPLFAYFIRD--WRMLLLALTLPGL-FCVPLWWFIPESPRWLISQRRFEEAEQIIQKAA 301

Query: 279 SEESADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMV 338
                   +V        L  +E  S  Q    I +LF  R      +  ++L +   + 
Sbjct: 302 KMNGIMAPAVIFDP----LELQELNSLKQQKVFILDLFKTRNIATITVMSVMLWMLTSVG 357

Query: 339 YFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYFL-ENLRRKPSILVFSILGGICCVTC 397
           YF + L V NL  ++YL    S  +E+P+    + L   L R+  I      GG   +  
Sbjct: 358 YFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLV 417

Query: 398 AVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFC 457
            V+        + L M+  FG  +A+++  ++  EL+PT VRN    +   A   G I  
Sbjct: 418 QVVPEDYNFVSIGLVMLGKFGVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIA 477

Query: 458 PFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
           P+ +  G  N +  Y + G + +L      F PE+ G+ L + ++Q +K
Sbjct: 478 PYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQK 526


>S223_HUMAN (O75751) Organic cation transporter 3 (Extraneuronal
           monoamine transporter) (EMT) (Solute carrier family 22,
           member 3)
          Length = 556

 Score =  158 bits (399), Expect = 4e-38
 Identities = 118/423 (27%), Positives = 206/423 (47%), Gaps = 21/423 (4%)

Query: 89  RSSWSWDTHPSNTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNML 148
           R  W +     +TI+S ++L C + ++  L Q+   +G L G+F L   AD   GR  + 
Sbjct: 128 RGGWRY-AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR-YGRIVIY 185

Query: 149 IFSCVSMSITSMLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIV 208
           + SC+ + +T +++ F+ N  ++   +FL G +         V++TE V ++ R  VGIV
Sbjct: 186 LLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIV 245

Query: 209 EYFTFTMGYMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREK 268
               FT+G + LPG AY   N  W+ + +  ++P+  + ++ Y  V ESPRWL+ + +  
Sbjct: 246 IQMFFTLGIIILPGIAYFIPN--WQGIQLAITLPSFLF-LLYYWVVPESPRWLITRKKGD 302

Query: 269 EILKMLKRVSSEESADDDSVNLASNL-PILPPKEKVSFFQLYSSIGELFHKRWAVIRMIA 327
           + L++L+R+     A  +   L+SN   I    E+VS       +     ++  +I M A
Sbjct: 303 KALQILRRI-----AKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFA 357

Query: 328 VMILGIGLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATYF-LENLRRKPSILVF 386
                +    VY G+ + +G +G N+Y+    S  +ELP  +     +E L R+      
Sbjct: 358 WFTSAV----VYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS 413

Query: 387 SILGGICCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLV 446
           +I+ G+ C+  A L   +   +  +A +   G   A+ +  +   EL+PT +RN   SL 
Sbjct: 414 NIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLC 473

Query: 447 RQAIVFGCIFCPFLISAGRKNNIY---SYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQ 503
                FG I  PFL+   R   ++      +FG++  +    +  LPET GI L +T+D 
Sbjct: 474 SGLCDFGGIIAPFLLF--RLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDD 531

Query: 504 QEK 506
            EK
Sbjct: 532 VEK 534


>ORCT_DROME (Q9VCA2) Organic cation transporter protein
          Length = 548

 Score =  131 bits (330), Expect = 4e-30
 Identities = 109/452 (24%), Positives = 204/452 (45%), Gaps = 17/452 (3%)

Query: 62  SIYTDNYPKWHCTNSICTSSSDICKLPRSSWSWDTHPS-NTIISHWNLECASTFITGLPQ 120
           S Y  +Y + +   SI  SS++      SS+ +D     N+ ++ WNL C+ + ++    
Sbjct: 77  SYYDVDYTEEYLNGSIPRSSNETKTC--SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSD 134

Query: 121 SSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALKFLIGF 180
           S F +G LLGS     ++D  +GRK     S V   I  +L   +   + Y+  + ++G 
Sbjct: 135 SLFMLGVLLGSLIFGQMSDK-LGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGA 193

Query: 181 WRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKSLYIWSS 240
             S +     V+  E V + +R   G+     F++G+M   GFAY   +  W+ L I  +
Sbjct: 194 TTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHD--WRWLQIAIT 251

Query: 241 VPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSE---ESADDDSVNLASNLPIL 297
           +P + + +  Y  + ES RWL+M+GR+ E   ++++ + E   E  ++    L   +   
Sbjct: 252 LPGLLF-LCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEK 310

Query: 298 PPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMIL---GIGLGMVYFGMPLAVGNLGFNIY 354
             +++++  Q  +++ +L   R+  +R   ++I     +  G VY+G+     NLG N  
Sbjct: 311 KKQDEMAASQPAATVFDLL--RYPNLRRKTLLIFFDWFVNSG-VYYGLSWNTNNLGGNQL 367

Query: 355 LAVVFSASMELPSCVATYFLENLRRKPSILVFSIL-GGICCVTCAVLENRVPAAKVVLAM 413
           +  + S ++E+P      F  N   + SIL  +++  GI  +    + + +    V  AM
Sbjct: 368 VNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAM 427

Query: 414 VAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFCPFLISAGRKNNIYSYG 473
           +      ++Y    I+  E FPT VRN            G I  P+L   G         
Sbjct: 428 IGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLI 487

Query: 474 VFGVVIMLSNFTLFFLPETIGIVLCDTMDQQE 505
           + G + + +      LPET+   + +T++  E
Sbjct: 488 ICGALSLTAGLLSLLLPETLNKPMPETIEDGE 519


>OCTL_DROME (Q95R48) Organic cation transporter-like protein
          Length = 567

 Score =  120 bits (301), Expect = 9e-27
 Identities = 106/456 (23%), Positives = 192/456 (41%), Gaps = 17/456 (3%)

Query: 62  SIYTDNYPKWHCTNSICTSSSDICKLPRSSWSWDTHPS-NTIISHWNLECASTFITGLPQ 120
           S Y  +Y + +   SI  SS++      SS+ +D     N+ ++ WNL C   F+     
Sbjct: 77  SYYDVDYTEEYLNGSIPRSSNETKTC--SSYVYDRSKYLNSAVTEWNLVCGRDFMAATSD 134

Query: 121 SSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALKFLIGF 180
           S F +G LLGS     L+D   GRK +L  S V   +  +L   +   + Y+  + ++G 
Sbjct: 135 SLFMLGVLLGSIVFGQLSDK-YGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGA 193

Query: 181 WRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKSLYIWSS 240
             S +     V+  E V  + R   GI     F++G+M    FAY   +  W+ L I  +
Sbjct: 194 TTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHD--WRWLQIALT 251

Query: 241 VPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSEESADDDSVNLASNLPILPPK 300
           +P + + +  Y  + ES RWL+++GR+   +  +++ +     +     L+  L      
Sbjct: 252 LPGLIF-MFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENS 310

Query: 301 EKVSFFQLYS---------SIGELFHKRWAVIRMIAVMILGIGLGMVYFGMPLAVGNLGF 351
           E+ +  +L           S+ +LF       + + + +  +    VY+G+     NLG 
Sbjct: 311 EEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGG 370

Query: 352 NIYLAVVFSASMELPSCVATYFLENLRRKPSILV-FSILGGICCVTCAVLENRVPAAKVV 410
           N+ L  V S ++E+P+ +      N   + SIL    ++ G+  +   ++  R+    V 
Sbjct: 371 NVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVA 430

Query: 411 LAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFCPFLISAGRKNNIY 470
            AM+       +Y    I+  E FPT VRN              +  PFL          
Sbjct: 431 CAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPL 490

Query: 471 SYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEK 506
              + G + +++      LPET    + +T+   E+
Sbjct: 491 PLLICGSLTLVAGLLSLLLPETHNKPMLETIADGER 526


>OCT1_CAEEL (Q9U539) Organic cation transporter 1 (CeOCT1)
          Length = 576

 Score =  114 bits (284), Expect = 8e-25
 Identities = 93/431 (21%), Positives = 186/431 (42%), Gaps = 8/431 (1%)

Query: 79  TSSSDICKLP-RSSWSWDTHPS-NTIISHWNLECASTFITGLPQSSFFIGCLLGSFFLAA 136
           T S  I  +P ++ W +D     +++++ +NL C       +  +SF++G  +G+     
Sbjct: 106 TYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGY 165

Query: 137 LADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALKFLIGFWRSSIGTCVLVLLTEK 196
           +AD   GR+         + +      F+ ++  +  L+F  G    ++     ++  E 
Sbjct: 166 VADK-FGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEF 224

Query: 197 VSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKSLYIWSSVPAICYSVIAYLFVTE 256
           +    R   G++    F      L   A   R   W+ L  + + P   Y +I Y F+ E
Sbjct: 225 MGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR--WRQLTFFCNAPFAFY-IIYYFFLPE 281

Query: 257 SPRWLVMQGREKEILKMLKRVSSEESADDDSVN-LASNLPILPPKEKVSFFQLYSSIGEL 315
           SPRW V  G+  +  K LK+++      +  V+ L  ++       +    +   ++ +L
Sbjct: 282 SPRWSVSVGKWADAKKQLKKIAKMNGKSNVDVDELVDSMKNHQNAAEEKETKRSHNVTDL 341

Query: 316 FHKRWAVIRMIAVMILGIGLGMVYFGMPLAVGNLGFNIYLAVVFSASMELPSCVATY-FL 374
           F       + + V  + +   ++Y G+ L V NL  + Y + + + ++ELP     +  L
Sbjct: 342 FKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLL 401

Query: 375 ENLRRKPSILVFSILGGICCVTCAVLENRVPAAKVVLAMVAFFGACTAYNVFLIYIIELF 434
           +   R+ ++    I+ GI CV+   + +  P      + +  FG  + + V  I+  EL+
Sbjct: 402 QCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELY 461

Query: 435 PTCVRNTTTSLVRQAIVFGCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIG 494
           PT VR     +       G +  P +++ G+   I    + G++ + +    FFLPET+G
Sbjct: 462 PTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLPETLG 521

Query: 495 IVLCDTMDQQE 505
             L  T++  E
Sbjct: 522 APLPMTIEDAE 532


>YT13_CAEEL (Q10917) Hypothetical protein B0252.3 in chromosome II
          Length = 484

 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 84/409 (20%), Positives = 173/409 (41%), Gaps = 23/409 (5%)

Query: 106 WNLECASTFITGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFS 165
           W  E  +TF        + +G ++G  F+  LAD   GR  + + + + M++  M+  FS
Sbjct: 91  WLAESTTTF--------YMVGNMIGGMFIPPLADH-YGRLPVFVATVLLMAVGGMISAFS 141

Query: 166 TNVWIYSALKFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAY 225
           T++ ++  ++ + G + ++ G    VL  E      RF   +     + +G   L   AY
Sbjct: 142 TSIMMFCIMRMIHGIFYTAAGLAGWVLGYENTPLRLRFFTSVYFGVMWVVGACFLGLLAY 201

Query: 226 INRNSSWKSLYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSEESADD 285
           I  +  W+ L    SVP I  +++ Y+ V ES  +LV   + ++I   L+++   +    
Sbjct: 202 ILPD--WRYLMFCISVPNIFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIRGPKG--- 256

Query: 286 DSVNLASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMVYFGMPLA 345
              +++++  +    E  S F+      E++  +  ++ ++ +  + I    +YFG+   
Sbjct: 257 ---DISASDIVEDRDENGSSFKTLCR--EMWKHKMFIVYVLVMTYIWIVDTFIYFGLAFY 311

Query: 346 VGNLGFNIYLAVVFSASMELPSCV-ATYFLENLRRKPSILVFSILGGICCVTCAVLENRV 404
             NL  N+YL  V  + +E P+ + +  F+    RK  I    I+ G+  +   +     
Sbjct: 312 STNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSE-- 369

Query: 405 PAAKVVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFCPFLISAG 464
            A  +   ++  F    ++    ++  E+FPT  RN           FG +  P+L    
Sbjct: 370 -AWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLT 428

Query: 465 RKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDTMDQQEKKEIALCD 513
             + +       ++ +        LPET+   L  T+ +   +   + D
Sbjct: 429 AVHALAPAITLSLIAVSGGLLTLILPETLNTKLPSTIAETASRRQLIDD 477


>HXT3_YEAST (P32466) Low-affinity glucose transporter HXT3
          Length = 567

 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 104/422 (24%), Positives = 175/422 (40%), Gaps = 45/422 (10%)

Query: 116 TGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWI-YSAL 174
           TGL  S F IGC +G   LA L D   GRK  LI   V   I  ++ I S N W  Y   
Sbjct: 112 TGLIVSIFNIGCAIGGIILAKLGDM-YGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIG 170

Query: 175 KFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKS 234
           + + G     I     +L++E    E R  +        T+G     G+       ++ +
Sbjct: 171 RIISGLGVGGIAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFL--GYCTNFGTKNYSN 228

Query: 235 LYIWSSVPAICYSVIAYL-----FVTESPRWLVMQGREKEILKMLKRVSSEESADDDSVN 289
              W     +C++   ++     FV ESPR+LV  G+  E    L +V+       D   
Sbjct: 229 SVQWRVPLGLCFAWALFMIGGMTFVPESPRYLVEAGQIDEARASLSKVNK---VAPDHPF 285

Query: 290 LASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIR--MIAVMILGIGL-----GMVYFGM 342
           +   L ++    + +     +S GELF  + A+ +  M+ +MI  +          Y+G 
Sbjct: 286 IQQELEVIEASVEEARAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGT 345

Query: 343 PL--AVGNLGFNIYLAVVFSASMELPSCVATYFLENLRRKPSILVFSILGGICC--VTCA 398
            +  AVG +  +   ++VF       +C + Y ++   R+ + L++  +G +CC  V  +
Sbjct: 346 TVFNAVG-MSDSFETSIVFGVVNFFSTCCSLYTVDRFGRR-NCLLYGAIGMVCCYVVYAS 403

Query: 399 VLENRV-----------PAAKVVLAMVAFFGACTAYN---VFLIYIIELFPTCVRNTTTS 444
           V   R+            A   ++    F+  C A     +  + I E FP  V++   S
Sbjct: 404 VGVTRLWPNGEGNGSSKGAGNCMIVFACFYIFCFATTWAPIAYVVISETFPLRVKSKAMS 463

Query: 445 LVRQAI-VFGCI---FCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDT 500
           +   A  ++G +   F PF+   G  N  Y Y   G ++    +  FF+PET G+ L + 
Sbjct: 464 IATAANWLWGFLIGFFTPFI--TGAINFYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEV 521

Query: 501 MD 502
            D
Sbjct: 522 ND 523


>HXT1_YEAST (P32465) Low-affinity glucose transporter HXT1
          Length = 570

 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 106/422 (25%), Positives = 178/422 (42%), Gaps = 45/422 (10%)

Query: 116 TGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWI-YSAL 174
           TGL  S F IGC +G   LA L D   GR+  LI   V  +I  ++ I S N W  Y   
Sbjct: 115 TGLIVSIFNIGCAIGGIVLAKLGDM-YGRRIGLIVVVVIYTIGIIIQIASINKWYQYFIG 173

Query: 175 KFLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKS 234
           + + G     I     +L++E   +E R  +        T+G     G+       ++ +
Sbjct: 174 RIISGLGVGGITVLSPMLISEVAPSEMRGTLVSCYQVMITLGIFL--GYCTNFGTKNYSN 231

Query: 235 LYIWSSVPAICYSVIAYL-----FVTESPRWLVMQGREKEILKMLKRVSSEESADDDSVN 289
              W     +C++   ++     FV ESPR+LV  GR  E    L +V+       D   
Sbjct: 232 SVQWRVPLGLCFAWALFMIGGMMFVPESPRYLVEAGRIDEARASLAKVNK---CPPDHPY 288

Query: 290 LASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIR--MIAVMILGIGL-----GMVYFGM 342
           +   L  +    +       +S GELF  + A+ +  M+ +MI  +          Y+G 
Sbjct: 289 IQYELETIEASVEEMRAAGTASWGELFTGKPAMFQRTMMGIMIQSLQQLTGDNYFFYYGT 348

Query: 343 PL--AVGNLGFNIYLAVVFSASMELPSCVATYFLENLRRKPSILVFSILGGICC--VTCA 398
            +  AVG L  +   ++VF       +C + Y ++   R+ + L++  +G +CC  V  +
Sbjct: 349 IVFQAVG-LSDSFETSIVFGVVNFFSTCCSLYTVDRFGRR-NCLMWGAVGMVCCYVVYAS 406

Query: 399 VLENRV-------PAAK----VVLAMVAFFGACTAYN---VFLIYIIELFPTCVRNTTTS 444
           V   R+       P++K     ++    F+  C A     +  + I E FP  V++   S
Sbjct: 407 VGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIAYVVISECFPLRVKSKCMS 466

Query: 445 LVRQAI-VFGCI---FCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDT 500
           +   A  ++G +   F PF+   G  N  Y Y   G ++    +  FF+PET G+ L + 
Sbjct: 467 IASAANWIWGFLISFFTPFI--TGAINFYYGYVFMGCMVFAYFYVFFFVPETKGLSLEEV 524

Query: 501 MD 502
            D
Sbjct: 525 ND 526


>YFIG_BACSU (P54723) Hypothetical metabolite transport protein yfiG
          Length = 482

 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 99/413 (23%), Positives = 168/413 (39%), Gaps = 57/413 (13%)

Query: 117 GLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALKF 176
           GL  SS  +G   G+ F   L+D   GR+  +++  +     ++   FS N  +  A +F
Sbjct: 63  GLVASSLLLGAAFGAMFGGRLSDRH-GRRKTILYLALLFIAATLGCTFSPNASVMIAFRF 121

Query: 177 LIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSSWKSLY 236
           L+G         V   L E   AE R R+         +G +    F  I  ++  +S  
Sbjct: 122 LLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVIGQLLAYTFNAIIGSTMGESAN 181

Query: 237 IW------SSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSEESADDDSVNL 290
           +W      +++PA+       L V ESPRWL  +GR  + L++L+++  +  A  +   +
Sbjct: 182 VWRYMLVIATLPAVVLW-FGMLIVPESPRWLAAKGRMGDALRVLRQIREDSQAQQEIKEI 240

Query: 291 ASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMV----------YF 340
                I    +K  F          F + W  IR I  + +GIG+ +V          Y+
Sbjct: 241 KH--AIEGTAKKAGFHD--------FQEPW--IRRI--LFIGIGIAIVQQITGVNSIMYY 286

Query: 341 GMPLAVGNLGFNIYLAVVFSASMELPSCVATYF----LENLRRKPSILVFSI-------L 389
           G  + +   GF    A++ + +  + S +A  F    L  +RR+P +++  I       L
Sbjct: 287 GTEI-LREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLIIGQIGTMTALLL 345

Query: 390 GGICCVTCAVLENRVPAAKVVLAMVAFFGA---CTAYNVFLIYIIELFPTCVRN-----T 441
            GI  +   VLE       VVL++   F A        V  + + E+FP  VR      +
Sbjct: 346 IGILSI---VLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPMHVRGLGMGIS 402

Query: 442 TTSLVRQAIVFGCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIG 494
           T  L     + G  F   L   G     + +    ++ +L  F   ++PET G
Sbjct: 403 TFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAIL--FVKKYVPETKG 453


>HXT5_YEAST (P38695) Probable glucose transporter HXT5
          Length = 592

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 103/426 (24%), Positives = 186/426 (43%), Gaps = 45/426 (10%)

Query: 116 TGLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALK 175
           TGL  S F IGC +G   L+ L D   GRK  L+   V  SI  ++ I S + W     +
Sbjct: 136 TGLMVSIFNIGCAIGGIVLSKLGDM-YGRKIGLMTVVVIYSIGIIIQIASIDKWY----Q 190

Query: 176 FLIGFWRSSIG----TCVLVLLTEKVSAEWRFRVGIVEYFTFTMGYMSLPGFAYINRNSS 231
           + IG   S +G    T +  +L  +VS + + R  +V  +   + +    G+       +
Sbjct: 191 YFIGRIISGLGVGGITVLAPMLISEVSPK-QLRGTLVSCYQLMITFGIFLGYCTNFGTKN 249

Query: 232 WKSLYIWSSVPAICYS-----VIAYLFVTESPRWLVMQGREKEILKMLKRV--SSEES-- 282
           + +   W     +C++     ++   FV ESPR+LV  G+ +E  + L R   ++E+S  
Sbjct: 250 YSNSVQWRVPLGLCFAWSIFMIVGMTFVPESPRYLVEVGKIEEAKRSLARANKTTEDSPL 309

Query: 283 ADDDSVNLASNLPILPPKEKVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMVYFGM 342
              +  N  S++         S+ +L +   ++F +    + + ++  L       Y+G 
Sbjct: 310 VTLEMENYQSSIEAERLAGSASWGELVTGKPQMFRRTLMGMMIQSLQQLTGDNYFFYYGT 369

Query: 343 PL--AVGNLGFNIYLAVVFSASMELPSCVATYFLENLRRKPSILVFSILGGICC--VTCA 398
            +  AVG L  +   A+V      + +  + Y ++   R+ + L++  +G ICC  V  +
Sbjct: 370 TIFQAVG-LEDSFETAIVLGVVNFVSTFFSLYTVDRFGRR-NCLLWGCVGMICCYVVYAS 427

Query: 399 VLENRV-------PAAK----VVLAMVAFFGACTAYN---VFLIYIIELFPTCVRNTTTS 444
           V   R+       P++K     ++    F+  C A     V  + I E +P  VR    S
Sbjct: 428 VGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPVAYVLISESYPLRVRGKAMS 487

Query: 445 LVRQA-IVFGCI---FCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVLCDT 500
           +      ++G +   F PF+ SA   N  Y Y   G ++    +  FF+PET G+ L + 
Sbjct: 488 IASACNWIWGFLISFFTPFITSA--INFYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEV 545

Query: 501 MDQQEK 506
            +  E+
Sbjct: 546 NEMYEE 551


>YAAU_ECOLI (P31679) Hypothetical metabolite transport protein yaaU
          Length = 443

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 88/399 (22%), Positives = 165/399 (41%), Gaps = 37/399 (9%)

Query: 117 GLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWIYSALKF 176
           GL  +    G  +G+     ++D  +GR+ M +   +++ + S+  +F ++      ++ 
Sbjct: 56  GLLGAGTLAGLFVGTSLFGYISDK-VGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRV 114

Query: 177 LIGFWRSSIGTCVLVLLTEKVSAEWR-FRVGIVEYFTFTMGYMS-LPGFAYINRNSSWKS 234
           LIG    +       ++TE  S   R F +  +    +     + L G+   +    W+ 
Sbjct: 115 LIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWLYDVEGGWRW 174

Query: 235 LYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSEESADDDSVNLASNL 294
           +   +++P +   +I    + ESPRWL+ +GR KE  +M+ ++  E  A D+     +  
Sbjct: 175 MLGSAAIPCLLI-LIGRFELPESPRWLLRKGRVKECEEMMIKLFGEPVAFDEEQPQQTRF 233

Query: 295 PILPPKEKVSFFQLYSSIGELFHKRWA--VIRMIAVMILG---IGLGMVYFGMPLAVGNL 349
             L  +    F    ++I       W   VI M A+   G   +GL  +  G   A+GN 
Sbjct: 234 RDLFNRRHFPFVLFVAAI-------WTCQVIPMFAIYTFGPQIVGLLGLGVGKNAALGN- 285

Query: 350 GFNIYLAVVFSASMELPSCVATYFLENLRRKPSIL-VFSILGGICCVTCAVLENRVPAAK 408
                  VV S    L       +L    R+P ++  F+++     V   + +  +    
Sbjct: 286 -------VVISLFFMLGCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPDMGIWLVV 338

Query: 409 VVLAMVAFFGACTAYNVFLIYIIELFPTCVRNTTTSLVRQAIVFGCIFCPFLISAGRKNN 468
           +  A+ AFF      N+  +Y  ELFPT +R +   ++      G I   + +       
Sbjct: 339 MAFAVYAFFSGGPG-NLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWALPI----F 393

Query: 469 IYSYGVFGVVIMLSNFTLF-------FLPETIGIVLCDT 500
           I +YG+   ++M +  +LF       F PET G+ L  T
Sbjct: 394 INNYGISNTMLMGAGISLFGLLISVAFAPETRGMSLAQT 432


>HXTG_YEAST (P53631) Hexose transporter HXT17
          Length = 564

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 94/419 (22%), Positives = 174/419 (41%), Gaps = 51/419 (12%)

Query: 117 GLPQSSFFIGCLLGSFFLAALADSSIGRKNMLIFSCVSMSITSMLIIFSTNVWI-YSALK 175
           GL  + F IGC +G    A LAD+ +GR+  ++   +   + +++ I S + W  Y   K
Sbjct: 109 GLLVAMFSIGCAIGGLIFARLADT-LGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGK 167

Query: 176 FLIGFWRSSIGTCVLVLLTEKVSAEWRFRVGIVEYFTFTM------GYMSLPGFAYINRN 229
            + G           +LL+E    +   R G+V  +   M      GY S+ G    +  
Sbjct: 168 IIYGLGAGGCSVLCPMLLSEIAPTD--LRGGLVSLYQLNMTFGIFLGYCSVYGTRKYDNT 225

Query: 230 SSWKS----LYIWSSVPAICYSVIAYLFVTESPRWLVMQGREKEILKMLKRVSSEESADD 285
           + W+      ++W+ +      +I  L V ESPR+L+   R +E    + +++     D 
Sbjct: 226 AQWRVPLGLCFLWTLI-----IIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDP 280

Query: 286 DSVNLAS--NLPILPPKE--KVSFFQLYSSIGELFHKRWAVIRMIAVMILGIGLGMVYFG 341
             +  A   N  +L  +E  + S+ +L+S   ++  +    I +   + L       ++G
Sbjct: 281 WVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYG 340

Query: 342 MPL--AVGNLGFNIYLAVVFSASMELPSCVATYFLENLRRKPSILVFSILGGICC----- 394
             +  +VG L      ++V        + +A   ++ + R+  +L F   G + C     
Sbjct: 341 TTIFKSVG-LTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLL-FGAAGMMACMVIFA 398

Query: 395 ---VTCAVLENRV-PAAK----VVLAMVAFFGACTAYN---VFLIYIIELFPTCVRNTTT 443
              V C     +  P++K     ++    F+  C A     V  I + E FP+ V++   
Sbjct: 399 SIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAM 458

Query: 444 SLVRQA-----IVFGCIFCPFLISAGRKNNIYSYGVFGVVIMLSNFTLFFLPETIGIVL 497
           S+          + G  F PF+   G  +  Y Y   G ++ +  +  FFLPETIG+ L
Sbjct: 459 SISTACNWLWQFLIG-FFTPFI--TGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSL 514


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.327    0.138    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,230,919
Number of Sequences: 164201
Number of extensions: 2308140
Number of successful extensions: 7355
Number of sequences better than 10.0: 132
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 7117
Number of HSP's gapped (non-prelim): 161
length of query: 526
length of database: 59,974,054
effective HSP length: 115
effective length of query: 411
effective length of database: 41,090,939
effective search space: 16888375929
effective search space used: 16888375929
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 68 (30.8 bits)