BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC119410.2 - phase: 1 /pseudo
(1273 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MRP2_HUMAN (Q92887) Canalicular multispecific organic anion tran... 416 e-115
MRP2_RABIT (Q28689) Canalicular multispecific organic anion tran... 407 e-113
MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1 (A... 407 e-112
MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion tran... 407 e-112
MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4 (M... 403 e-111
MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1 (A... 402 e-111
MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5 400 e-111
MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (A... 397 e-109
MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5 (M... 397 e-109
MRP2_RAT (Q63120) Canalicular multispecific organic anion transp... 394 e-109
MRP3_HUMAN (O15438) Canalicular multispecific organic anion tran... 392 e-108
YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium... 390 e-107
MRP3_RAT (O88563) Canalicular multispecific organic anion transp... 389 e-107
YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c 382 e-105
BPT1_YEAST (P14772) Bile pigment transporter 1 363 2e-99
ACC9_MOUSE (P70170) Sulfonylurea receptor 2 352 3e-96
ACC9_RAT (Q63563) Sulfonylurea receptor 2 352 4e-96
ACC8_RAT (Q09429) Sulfonylurea receptor 1 351 6e-96
ACC9_RABIT (P82451) Sulfonylurea receptor 2 349 2e-95
ACC8_HUMAN (Q09428) Sulfonylurea receptor 1 348 5e-95
>MRP2_HUMAN (Q92887) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein)
Length = 1545
Score = 416 bits (1068), Expect = e-115
Identities = 255/727 (35%), Positives = 390/727 (53%), Gaps = 64/727 (8%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSA-------- 640
L+ KT +LVTH + FL +VD I+ +G +++ GSY LL F +
Sbjct: 810 LKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPE 869
Query: 641 HKVTINDLNQN--------SEVLSNPQDSHGFYLTK-----------NQSEGE-ISSIQG 680
+ T++D ++ S V P+D+ + + ++S G + S++
Sbjct: 870 EEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRN 929
Query: 681 SIGAQ----LTQEEEKVIGN---------VGWKPLWDYINYSN--GTLMSCLVILGQCCF 725
S+ + L ++EE V G G Y+ Y G +IL
Sbjct: 930 SLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMN 989
Query: 726 LALQTSSNFWLATAIEIPKVTDTT---------LIGVYALLSISSTSFVYVRSYFAALLG 776
SN WL+ K+ ++T +GVY L ++ FV++ +++A
Sbjct: 990 SVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF 1049
Query: 777 LKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEV 829
+ AS +I APM FFD+TP + D+S +D +P SL + +
Sbjct: 1050 VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGI 1109
Query: 830 LVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLG 889
+ + +I T I+ +P + + +Q +Y +T+R+L R++ T++P+ + +ET G
Sbjct: 1110 ISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSG 1169
Query: 890 VVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILL 949
+ +RAF RF K+ +DT+ F + WL +R+E + NLTV +AL++++
Sbjct: 1170 LPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIY 1229
Query: 950 PQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDN 1009
LS VG LS AL + + R S + I++VERI ++ + E P + D
Sbjct: 1230 RDT-LSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDK 1288
Query: 1010 NRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISAL 1069
RPP WPSKGKI +VRYRP LVL+GITC ++GVVGRTG+GKS+L + L
Sbjct: 1289 -RPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCL 1347
Query: 1070 FRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIW 1129
FR++E + G I+IDG++I S+GL DLR KL+IIPQ+P LF GS+R NLDP YSD+EIW
Sbjct: 1348 FRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIW 1407
Query: 1130 KAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASI 1189
KA+E LK ++ L L V++ GGN S+GQRQL CLGR LL++++ILVLDEATA++
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1190 DSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
D TD ++Q I+ EF CTVIT+AHR+ T++DSD VMVL GK++E P +L+
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1250 FSKLVAE 1256
F + E
Sbjct: 1528 FYFMAKE 1534
Score = 71.2 bits (173), Expect = 2e-11
Identities = 34/75 (45%), Positives = 50/75 (66%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+Q + +F W+H+S + ++DVNL+I Q +AV PVGS KSS + A+LGE+ + G
Sbjct: 636 AMQFSEASFTWEHDSEA-TVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGH 694
Query: 479 VYVGGTLAYVSQSSW 493
+ + GT AYV Q SW
Sbjct: 695 ITIKGTTAYVPQQSW 709
Score = 68.9 bits (167), Expect = 8e-11
Identities = 54/217 (24%), Positives = 98/217 (44%), Gaps = 16/217 (7%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
++ + G V V+G GSGKS+LISA+ +E G I I G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 1099 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGN 1158
+ +PQ+ + G+I+ N+ +++ + +E C L + LP + + ++G N
Sbjct: 702 -AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGIN 760
Query: 1159 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAH 1215
S GQ+Q L R + I +LD+ +++D+ I +++ + T + V H
Sbjct: 761 LSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTH 820
Query: 1216 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSK 1252
+ + D ++VL G +VE S L+ F+K
Sbjct: 821 SMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
>MRP2_RABIT (Q28689) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein) (Epithelial
basolateral chloride conductance r
Length = 1564
Score = 407 bits (1047), Expect = e-113
Identities = 259/731 (35%), Positives = 388/731 (52%), Gaps = 72/731 (9%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF----ELLV----SA 640
L KT +LVTH + FL +VD I+ +G +++ GSY +LL F ++ V S
Sbjct: 808 LNGKTRLLVTHSLHFLPQVDEIVVVENGTILEKGSYSSLLAKKGVFAKNLKMFVKHTDSE 867
Query: 641 HKVTINDLNQN---------SEVLSNPQDSHGFYLTK-----------NQSEGE-ISSIQ 679
+VT+ND ++ S + P+DS L + ++S G + S++
Sbjct: 868 GEVTVNDGSEEDDDDDSGLISSIEEFPEDSISLTLKRENSLHRTLSRSSRSSGRRLKSLK 927
Query: 680 GSIGAQ---LTQEEEKVIGN---------VGWKPLWDYINYSNGTLMSCLV------ILG 721
S+ AQ +EEE V G G Y+ Y +V +L
Sbjct: 928 NSLKAQNGKTPKEEEVVKGQKLIKKEFMETGKVKFSIYLKYLQAIGWCSIVGIIFAYVLN 987
Query: 722 QCCFLALQTSSNFWLAT---------AIEIPKVTDTTLIGVYALLSISSTSFVYVRSYFA 772
F+ SN WL+ P IG++ +L ++ V V S+++
Sbjct: 988 SVAFIG----SNLWLSAWTSDSNTYNGTNYPASQRDLRIGIFGVLGLAQGLTVLVASFWS 1043
Query: 773 ALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIV 825
A AS +I APM FF++TP + D+S +D +P SL +
Sbjct: 1044 ASGCAHASNILHKQLLNNILRAPMSFFNTTPIGRIVNRFAGDISTVDDTLPQSLRSWMMC 1103
Query: 826 AIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAE 885
+ ++ + +I T ++ +P + + +Q +Y AT+R+L R++ T++P+ + E
Sbjct: 1104 FLAIISTLIMICMATPVFAVIIIPLAIIYVAVQVFYVATSRQLRRLDSVTRSPIYSHFTE 1163
Query: 886 THLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALL 945
T G+ +RAF RF K +DT+ + WL R+E + NL V ++AL+
Sbjct: 1164 TVSGLPVIRAFEHQQRFLKQNEIGIDTNQKCVSSWITSNRWLAFRLELVGNLVVFSSALM 1223
Query: 946 LILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPA 1005
+++ LS VG LS AL + + R S I++VERI ++I + E P
Sbjct: 1224 MVIYRDT-LSGDVVGFVLSNALNITQTLNWLVRMTSETETNIVAVERITEYIKVENEAPW 1282
Query: 1006 IVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTL 1065
+ D RPP+ WP KG+I +VRYRP LVLKGI C K ++GVVGRTG+GKS+L
Sbjct: 1283 VTDK-RPPAGWPHKGEIQFSNYQVRYRPELDLVLKGINCDIKSMEKIGVVGRTGAGKSSL 1341
Query: 1066 ISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSD 1125
+ LFR++E + G I IDGI+I S+GL DLR KL+IIPQ+P LF GS+R NLDP YSD
Sbjct: 1342 TNCLFRILEAAGGHITIDGIDIASIGLHDLRGKLTIIPQDPVLFSGSLRMNLDPFNNYSD 1401
Query: 1126 DEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEA 1185
+EIW+A+E LK ++ L L VS+ N S+GQRQL CLGR LL++++ILVLDEA
Sbjct: 1402 EEIWRALELAHLKSFVAGLQHGLSREVSEAEDNLSIGQRQLLCLGRALLRKSKILVLDEA 1461
Query: 1186 TASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMD 1245
TA++D TD ++Q IR EF CTVIT+AHR+ T++DSD +MVL G +VEY P +L++
Sbjct: 1462 TAAVDLETDHLIQTTIRNEFSHCTVITIAHRLHTIMDSDKIMVLDNGNIVEYGSPEELLE 1521
Query: 1246 TNSSFSKLVAE 1256
+ FS + E
Sbjct: 1522 SAGPFSLMAKE 1532
Score = 67.4 bits (163), Expect = 2e-10
Identities = 53/222 (23%), Positives = 98/222 (43%), Gaps = 16/222 (7%)
Query: 1034 NAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLK 1093
N ++ + G V VVG GSGKS+L+SA+ +E G I I G
Sbjct: 647 NLEPTIRNVNLDIMPGQLVAVVGTVGSGKSSLMSAMLGEMENVHGHITIKGTT------- 699
Query: 1094 DLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVS 1153
+ +PQ+ + G+I+ N+ + + + +E C L + LP + +
Sbjct: 700 ------AYVPQQSWIQNGTIKDNILFGAEFDERRYQRVLEACALLPDLEILPGGDLAEIG 753
Query: 1154 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTV 1210
++G N S GQ+Q L R + + I +LD+ +++D+ I +++ T
Sbjct: 754 EKGINLSGGQKQRISLARASYQNSDIYILDDPLSAVDAHVGKHIFNKVLGPNGLLNGKTR 813
Query: 1211 ITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSK 1252
+ V H + + D ++V+ G ++E S L+ F+K
Sbjct: 814 LLVTHSLHFLPQVDEIVVVENGTILEKGSYSSLLAKKGVFAK 855
Score = 66.2 bits (160), Expect = 5e-10
Identities = 32/75 (42%), Positives = 48/75 (63%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+Q + +F WD ++ P +++VNL+I Q +AV VGS KSS + A+LGE+ + G
Sbjct: 634 AVQFSEASFTWDR-NLEPTIRNVNLDIMPGQLVAVVGTVGSGKSSLMSAMLGEMENVHGH 692
Query: 479 VYVGGTLAYVSQSSW 493
+ + GT AYV Q SW
Sbjct: 693 ITIKGTTAYVPQQSW 707
>MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1531
Score = 407 bits (1046), Expect = e-112
Identities = 255/713 (35%), Positives = 378/713 (52%), Gaps = 50/713 (7%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTIN-- 646
L++KT ILVTH + +L +VD I+ GK+ + GSY+ LL AF + + T
Sbjct: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQ 876
Query: 647 DLNQNSEV-LSNP-------------QDSHGFYLTKNQSE-----GEISSIQGSIGA--- 684
D +N +S P DS G L + S G+IS S
Sbjct: 877 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 936
Query: 685 ---------QLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFW 735
+L + ++ G V WDY+ + G +S L I C +SN+W
Sbjct: 937 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMK-AIGLFISFLSIFLFMCNHVSALASNYW 995
Query: 736 LATAIEIPKVTDT-----TLIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTS 790
L+ + P V T + VY L IS V+ S ++ G+ AS S
Sbjct: 996 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 1055
Query: 791 IFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQV 843
I +PM FF+ TP+ S +L +D IP + V+ VI T
Sbjct: 1056 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1115
Query: 844 LIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFF 903
I+ P + F+Q++Y A++R+L R+ +++PV + ET LGV +RAF +RF
Sbjct: 1116 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1175
Query: 904 KNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSL 963
VD + ++ S VA WL +R+E + N V+ AAL ++ + LS G VGLS+
Sbjct: 1176 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSV 1234
Query: 964 SYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKID 1023
SY+L + + R S + I++VER+K++ E P + PPSSWP G+++
Sbjct: 1235 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVE 1294
Query: 1024 LQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILID 1083
+ +RYR + VL+ I T GG +VG+VGRTG+GKS+L LFR+ E + G+I+ID
Sbjct: 1295 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1354
Query: 1084 GINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISK 1143
GINI +GL DLR K++IIPQ+P LF GS+R NLDP YSD+E+W ++E LK+ +S
Sbjct: 1355 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1414
Query: 1144 LPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQ 1203
LP LD ++ G N S+GQRQL CL R LL++ +ILVLDEATA++D TD ++Q IR
Sbjct: 1415 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1474
Query: 1204 EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 1256
+FE+CTV+T+AHR+ T++D V+VL G++ EY PS L+ F + +
Sbjct: 1475 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKD 1527
Score = 88.6 bits (218), Expect = 1e-16
Identities = 71/285 (24%), Positives = 137/285 (47%), Gaps = 21/285 (7%)
Query: 981 SNLSNYIISVERIKQFI-HIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVL 1039
S++ +S++R++ F+ H EP +I RP I ++ + + P L
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSI--ERRPVKDGGGTNSITVRNATFTWARSDPPTL 661
Query: 1040 KGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKL 1099
GIT + G+ V VVG+ G GKS+L+SAL ++ G + I G +
Sbjct: 662 NGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SV 708
Query: 1100 SIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGN 1158
+ +PQ+ + S+R N+ G ++ +++V + C L + LPS + + ++G N
Sbjct: 709 AYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVN 767
Query: 1159 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRII--RQEFEECTVITVAH 1215
S GQ+Q L R + I + D+ +++D+ I + +I + + T I V H
Sbjct: 768 LSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTH 827
Query: 1216 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSS 1260
+ + D+++V+S GK+ E +L+ + +F++ + Y S+
Sbjct: 828 SMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 872
Score = 53.9 bits (128), Expect = 3e-06
Identities = 28/76 (36%), Positives = 42/76 (54%), Gaps = 1/76 (1%)
Query: 418 NALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISG 477
N++ +++ TF W S P L + I +AV VG KSS L A+L E+ K+ G
Sbjct: 642 NSITVRNATFTWAR-SDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 478 TVYVGGTLAYVSQSSW 493
V + G++AYV Q +W
Sbjct: 701 HVAIKGSVAYVPQQAW 716
>MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2)
Length = 1543
Score = 407 bits (1045), Expect = e-112
Identities = 257/728 (35%), Positives = 386/728 (52%), Gaps = 66/728 (9%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLL-KSG---------------- 631
L KT ILVTH + FL +VD I+ G +++ GSY +L+ K G
Sbjct: 808 LSGKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPE 867
Query: 632 --------------------TAFELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQS 671
T E+ A +T+ N LS S +S
Sbjct: 868 GEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKS 927
Query: 672 EGEISSIQGSI-------GAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCC 724
+I S+ G +L ++E G V + Y+ + +VI
Sbjct: 928 SLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLN 987
Query: 725 FLALQTSSNFWLA---TAIEIPKVTDTT------LIGVYALLSISSTSFVYVRSYFAALL 775
++A +N WL+ + E TD + IGV+ L I+ F+ S ++
Sbjct: 988 YVAF-IGTNLWLSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYA 1046
Query: 776 GLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIE 828
AS T+I APM FFD+TP + D+S +D +P +L +
Sbjct: 1047 CRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFG 1106
Query: 829 VLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHL 888
++ + +I T +I+ +P + + +Q +Y AT+R+L R++ TK+P+ + +ET
Sbjct: 1107 IVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVS 1166
Query: 889 GVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLIL 948
G+ +RAF RF N K +DT+ F + WL +R+E + NL V +ALLL++
Sbjct: 1167 GLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVI 1226
Query: 949 LPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVD 1008
+ L+ VG LS AL + + R S + I++VERI ++I++ E P + D
Sbjct: 1227 Y-KNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTD 1285
Query: 1009 NNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISA 1068
+PP+ WP KG+I +VRYRP LVLKGITC K +VGVVGRTG+GKS+L +
Sbjct: 1286 K-KPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNC 1344
Query: 1069 LFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEI 1128
LFR++E + G I+IDGI+I S+GL DLR +L+IIPQ+P LF G++R NLDP YSD+EI
Sbjct: 1345 LFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEI 1404
Query: 1129 WKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATAS 1188
W+A+E LK ++ L L V++ G N S+GQRQL CLGR +L++++ILVLDEATA+
Sbjct: 1405 WRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAA 1464
Query: 1189 IDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNS 1248
+D TD+++Q IR EF +CTVIT+AHR+ T++DSD +MVL GK+VEY P +L+
Sbjct: 1465 VDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSNMG 1524
Query: 1249 SFSKLVAE 1256
F + E
Sbjct: 1525 PFYLMAKE 1532
Score = 79.7 bits (195), Expect = 5e-14
Identities = 62/232 (26%), Positives = 105/232 (44%), Gaps = 20/232 (8%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
++ + K G V VVG GSGKS+LISA+ +E G I I G
Sbjct: 652 IQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKG-------------S 698
Query: 1099 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGN 1158
++ +PQ+ + G+I+ N+ Y + + + +E C L + LP + + ++G N
Sbjct: 699 IAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGIN 758
Query: 1159 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAH 1215
S GQ+ L R + I +LD+ +++D+ I +++ T I V H
Sbjct: 759 LSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTH 818
Query: 1216 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSLP 1267
+ + D ++VL G ++E S LMD F+K W + K+S P
Sbjct: 819 GIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAK----NWKTFMKHSGP 866
Score = 65.9 bits (159), Expect = 7e-10
Identities = 31/75 (41%), Positives = 49/75 (65%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+Q + +F WD + + ++DVNL+IK Q +AV VGS KSS + A+LGE+ + G
Sbjct: 634 AVQFSEASFTWDRD-LEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGH 692
Query: 479 VYVGGTLAYVSQSSW 493
+ + G++AYV Q +W
Sbjct: 693 ITIKGSIAYVPQQAW 707
>MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4
(MRP/cMOAT-related ABC transporter) (Multi-specific
organic anion tranporter-B) (MOAT-B)
Length = 1325
Score = 403 bits (1036), Expect = e-111
Identities = 246/713 (34%), Positives = 390/713 (54%), Gaps = 43/713 (6%)
Query: 580 SCNTIQYCVMTALRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFEL 636
S + + C+ L +K ILVTHQ+++L IL DGK++Q G+Y LKSG F
Sbjct: 570 SRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGS 629
Query: 637 LVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKN---QSEGEISSIQGSIGAQLTQ----- 688
L+ N+ ++ V P + + + Q S G++ +Q T+
Sbjct: 630 LLKKD----NEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVT 685
Query: 689 --EEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVT 746
EE + G VG++ +Y ++ +IL ++WL+ +
Sbjct: 686 LSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSML 745
Query: 747 DTTL---------------IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSI 791
+ T+ +G+Y+ L++++ F RS + + +S + SI
Sbjct: 746 NVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESI 805
Query: 792 FNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVL 844
AP+LFFD P S D+ LD +P + ++V+ ++ V +V +
Sbjct: 806 LKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIA 865
Query: 845 IVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFK 904
I VP + IF+++Y+ T+R++ R+ TT++PV + + + G+ T+RA+ +R +
Sbjct: 866 IPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQE 925
Query: 905 NYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLS 964
+ D + +F W +R++A+ + VI A ++L + L G+VGL+LS
Sbjct: 926 LFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKT-LDAGQVGLALS 984
Query: 965 YALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDL 1024
YALTL G + R + + N +ISVER+ ++ + E P RPP +WP +G I
Sbjct: 985 YALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK-RPPPAWPHEGVIIF 1043
Query: 1025 QGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDG 1084
+ Y P PLVLK +T K +VG+VGRTG+GKS+LISALFRL EP G I ID
Sbjct: 1044 DNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDK 1102
Query: 1085 INICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKL 1144
I +GL DLR K+SIIPQEP LF G++R NLDP ++D+E+W A+++ QLKETI L
Sbjct: 1103 ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFKEHTDEELWNALQEVQLKETIEDL 1162
Query: 1145 PSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQE 1204
P +D+ +++ G N+S+GQRQL CL R +L++N+IL++DEATA++D TD ++Q+ IR++
Sbjct: 1163 PGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREK 1222
Query: 1205 FEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS-FSKLVAE 1256
F CTV+T+AHR+ T+IDSD +MVL G+L EYDEP L+ S F K+V +
Sbjct: 1223 FAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQ 1275
Score = 88.6 bits (218), Expect = 1e-16
Identities = 73/298 (24%), Positives = 141/298 (46%), Gaps = 29/298 (9%)
Query: 966 ALTLNGA-----QIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKG 1020
A+TL GA +F+ +S I+S+ RI+ F+ + I NR PS G
Sbjct: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDE----ISQRNR---QLPSDG 406
Query: 1021 K--IDLQGLEVRY-RPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSR 1077
K + +Q + + + L+G++ T + G + VVG G+GKS+L+SA+ + PS
Sbjct: 407 KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSH 466
Query: 1078 GDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQL 1137
G + + G +++ + Q+P +F G++R+N+ Y + K ++ C L
Sbjct: 467 GLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACAL 513
Query: 1138 KETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-I 1196
K+ + L + + D G S GQ+ L R + + I +LD+ +++D+ +
Sbjct: 514 KKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHL 573
Query: 1197 LQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLV 1254
+ I Q E I V H++ + + +++L GK+V+ ++ + + F L+
Sbjct: 574 FELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
Score = 63.5 bits (153), Expect = 3e-09
Identities = 31/74 (41%), Positives = 45/74 (59%)
Query: 420 LQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTV 479
+ +QD T WD S +P L+ ++ ++ + +AV PVG+ KSS L A+LGE+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 480 YVGGTLAYVSQSSW 493
V G +AYVSQ W
Sbjct: 470 SVHGRIAYVSQQPW 483
>MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1528
Score = 402 bits (1032), Expect = e-111
Identities = 243/713 (34%), Positives = 382/713 (53%), Gaps = 47/713 (6%)
Query: 589 MTALRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTI 645
M L++KT ILVTH + +L +VD I+ GK+ + GSY+ LL AF + +
Sbjct: 814 MGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAE 873
Query: 646 NDLNQNSEVLSNP-------------QDSHGFYLTKNQSE-----GEISSIQGSIGA--- 684
DL + +S D+ G +L ++ S G+ S SI
Sbjct: 874 QDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQK 933
Query: 685 --------QLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWL 736
+L + ++ G V W+Y+ + G ++ L I C +SN+WL
Sbjct: 934 AGAKEETWKLMEADKAQTGQVQLSVYWNYMK-AIGLFITFLSIFLFLCNHVSALASNYWL 992
Query: 737 ATAIEIPKVTDTTL------IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTS 790
+ + P V + T + VY L I + ++ S ++ G+ AS +
Sbjct: 993 SLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYN 1052
Query: 791 IFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQV 843
+ +PM FF+ TP+ S +L +D IP + V+ + +I T
Sbjct: 1053 VLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIA 1112
Query: 844 LIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFF 903
++ P + F+Q++Y A++R+L R+ +++PV + ET LGV +RAF +RF
Sbjct: 1113 AVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1172
Query: 904 KNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSL 963
VD + ++ S VA WL +R+E + N V+ AAL ++ + LS G VGLS+
Sbjct: 1173 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSV 1231
Query: 964 SYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKID 1023
SY+L + + R S + I++VER+K++ E P + PPS+WP G+++
Sbjct: 1232 SYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVE 1291
Query: 1024 LQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILID 1083
+ +RYR + LVLK I T +GG +VG+VGRTG+GKS+L LFR+ E + G+I+ID
Sbjct: 1292 FRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1351
Query: 1084 GINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISK 1143
G+NI +GL +LR K++IIPQ+P LF GS+R NLDP YSD+E+W A+E LK +S
Sbjct: 1352 GVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSA 1411
Query: 1144 LPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQ 1203
LP L+ ++ G N S+GQRQL CL R LL++ +ILVLDEATA++D TD ++Q IR
Sbjct: 1412 LPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRT 1471
Query: 1204 EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 1256
+FE+CTV+T+AHR+ T++D V+VL G++ E PS+L+ F + +
Sbjct: 1472 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKD 1524
Score = 87.4 bits (215), Expect = 2e-16
Identities = 71/282 (25%), Positives = 134/282 (47%), Gaps = 22/282 (7%)
Query: 981 SNLSNYIISVERIKQFI-HIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVL 1039
S++ +S++R++ F+ H EP +I R I ++ + P L
Sbjct: 605 SSIVQASVSLKRLRIFLSHEELEPDSI---ERRSIKSGEGNSITVKNATFTWARGEPPTL 661
Query: 1040 KGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKL 1099
GIT + G+ V VVG+ G GKS+L+SAL ++ G + + G +
Sbjct: 662 NGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKG-------------SV 708
Query: 1100 SIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGN 1158
+ +PQ+ + S+R N+ G + +KAV E C L + LPS + + ++G N
Sbjct: 709 AYVPQQAWIQNDSLRENI-LFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVN 767
Query: 1159 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAH 1215
S GQ+Q L R + + I + D+ +++D+ I ++++ + T I V H
Sbjct: 768 LSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTH 827
Query: 1216 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEY 1257
+ + D+++V+S GK+ E +L+D + +F++ + Y
Sbjct: 828 GISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY 869
Score = 52.0 bits (123), Expect = 1e-05
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 418 NALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISG 477
N++ +++ TF W P L + I +AV VG KSS L A+L E+ K+ G
Sbjct: 642 NSITVKNATFTWARGE-PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 478 TVYVGGTLAYVSQSSW 493
V + G++AYV Q +W
Sbjct: 701 HVTLKGSVAYVPQQAW 716
>MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5
Length = 1436
Score = 400 bits (1029), Expect = e-111
Identities = 246/695 (35%), Positives = 379/695 (54%), Gaps = 44/695 (6%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFE--LLVSAHK 642
L+ KTV+ VTHQ+++L + D ++ +G + + G++E L+ T F LL
Sbjct: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
Query: 643 VTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPL 702
V IN + S S G + E + S +G QL Q EEK G+V W
Sbjct: 792 VEINSKKEASG--SQKSQDKGPKPGSVKKEKAVKSEEG----QLVQVEEKGQGSVPWSVY 845
Query: 703 WDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIGVYALLSISST 762
W YI + G L ++++ + S +WL+ I+ T G + +S S
Sbjct: 846 WVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVFEGNRSSVSDSMR 905
Query: 763 SFVYVRSYFA-------------ALLG-------LKASTAFFSSFTTSIFNAPMLFFDST 802
+++ Y + A+ G L+AS+ I +PM FFD+T
Sbjct: 906 DNPFLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT 965
Query: 803 PA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALI 855
P S D+ +D +P+ I V + +IA V L+ P ++
Sbjct: 966 PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFS 1025
Query: 856 FIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYLKLVDTDAS 915
+ + REL R++ T++P ++ + G+ T+ A+N F Y +L+D + +
Sbjct: 1026 VLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQA 1085
Query: 916 LFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIF 975
FF AM WL +R++ L+++ +IT L+I+L + GL++SYA+ L G F
Sbjct: 1086 PFFLFTCAMRWLAVRLD-LISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQF 1144
Query: 976 WTRWFSNLSNYIISVERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPN 1034
R S SVERI +I + E PA + N PP WP +G+I + E+RYR N
Sbjct: 1145 TVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYREN 1204
Query: 1035 APLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD 1094
PLVLK ++ T K ++G+VGRTGSGKS+L ALFRLVE S G I IDG+ I +GL D
Sbjct: 1205 LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1264
Query: 1095 LRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSD 1154
LR KL+IIPQEP LF G++R+NLDP Y++++IW A+E+ +KE I++LP L+S V +
Sbjct: 1265 LRSKLTIIPQEPVLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVME 1324
Query: 1155 EGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVA 1214
G N+S+G+RQL C+ R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+A
Sbjct: 1325 NGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIA 1384
Query: 1215 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
HR+ TV+ SD +MVL+ G++VE+D PS L+ +SS
Sbjct: 1385 HRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSS 1419
Score = 82.4 bits (202), Expect = 7e-15
Identities = 64/250 (25%), Positives = 115/250 (45%), Gaps = 21/250 (8%)
Query: 1006 IVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTL 1065
++D++ PS +GK G R L I + G VG+ G GSGK++L
Sbjct: 550 LLDSDERPSPEEEEGKQIHAGSMRLQR-----TLYNIDLEIEEGKLVGICGSVGSGKTSL 604
Query: 1066 ISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSD 1125
ISA+ + G I + G + + Q+ + ++R N+ G D
Sbjct: 605 ISAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEFD 650
Query: 1126 DEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDE 1184
+E + +V C L+ ++ LP+ + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 1185 ATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKL 1243
+++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 1244 MDTNSSFSKL 1253
M+ N ++ +
Sbjct: 771 MNLNGDYATI 780
Score = 53.5 bits (127), Expect = 4e-06
Identities = 23/56 (41%), Positives = 39/56 (69%)
Query: 438 LKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGGTLAYVSQSSW 493
L +++LEI+ + + +C VGS K+S + AILG++ + G++ V GT AYV+Q +W
Sbjct: 578 LYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAW 633
>MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (ABC
transporter MOAT-C) (SMRP)
Length = 1436
Score = 397 bits (1019), Expect = e-109
Identities = 240/693 (34%), Positives = 376/693 (53%), Gaps = 40/693 (5%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFELLVSAHKVT 644
L+ KTV+ VTHQ+++L + D ++ +G + + G++E L+ T F L+
Sbjct: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
Query: 645 INDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPLWD 704
+ ++ S G + E + S +G QL Q EEK G+V W W
Sbjct: 792 VEINSKKEATGSQKSQDKGPKPGSVKKEKAVKSEEG----QLVQVEEKGQGSVPWSVYWV 847
Query: 705 YINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIGVYALLSISSTSF 764
YI + G L ++++ + S +WL+ I+ T G + +S S
Sbjct: 848 YIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKDN 907
Query: 765 VYVRSYFA-------------ALLG-------LKASTAFFSSFTTSIFNAPMLFFDSTPA 804
+++ Y + A+ G L+AS+ I +PM FFD+TP
Sbjct: 908 PFMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPT 967
Query: 805 -------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFI 857
S D+ +D +P+ I V + +IA V L+ P ++ +
Sbjct: 968 GRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLL 1027
Query: 858 QKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYLKLVDTDASLF 917
+ REL R++ T++P ++ + G+ T+ A+N F Y +L+D + + F
Sbjct: 1028 HIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPF 1087
Query: 918 FHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWT 977
F AM WL +R++ ++++ +IT+ L+I+ GL++SYA+ L G F
Sbjct: 1088 FLFTCAMRWLPVRLD-IISIALITSTGLMIVSGMARSLSAYAGLAISYAVQLIGLFQFTV 1146
Query: 978 RWFSNLSNYIISVERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAP 1036
R S SVERI +I + E PA + N PP WP +G++ + E+RYR N P
Sbjct: 1147 RLASETEARFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENLP 1206
Query: 1037 LVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLR 1096
LVLK ++ T K ++G+VGRTGSGKS+L ALFRLVE S G I IDGI I +GL DLR
Sbjct: 1207 LVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLR 1266
Query: 1097 MKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEG 1156
KL+IIPQEP LF G++R+NLDP Y++D+IW A+E+ +KE I++LP L+S V + G
Sbjct: 1267 SKLAIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENG 1326
Query: 1157 GNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHR 1216
N+S+G+RQL C+ R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+AHR
Sbjct: 1327 DNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHR 1386
Query: 1217 VPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
+ TV+ SD +MVL+ G++VE+D PS L+ +SS
Sbjct: 1387 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSS 1419
Score = 82.0 bits (201), Expect = 9e-15
Identities = 63/251 (25%), Positives = 117/251 (46%), Gaps = 23/251 (9%)
Query: 1006 IVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKST 1064
++D++ PS +GK I L ++ L I + G VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKQIHTGSLRLQR------TLYNIDLEIEEGKLVGICGSVGSGKTS 603
Query: 1065 LISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYS 1124
L+SA+ + G I + G + + Q+ + ++R N+ G
Sbjct: 604 LVSAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEF 649
Query: 1125 DDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLD 1183
D+E + +V C L+ ++ LP+ + + + G N S GQRQ L R L I +LD
Sbjct: 650 DEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILD 709
Query: 1184 EATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSK 1242
+ +++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +
Sbjct: 710 DPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769
Query: 1243 LMDTNSSFSKL 1253
LM+ N ++ +
Sbjct: 770 LMNLNGDYATI 780
Score = 53.1 bits (126), Expect = 5e-06
Identities = 23/56 (41%), Positives = 39/56 (69%)
Query: 438 LKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGGTLAYVSQSSW 493
L +++LEI+ + + +C VGS K+S + AILG++ + G++ V GT AYV+Q +W
Sbjct: 578 LYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAW 633
>MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5
(Multi-specific organic anion tranporter-C) (MOAT-C)
(pABC11) (SMRP)
Length = 1437
Score = 397 bits (1019), Expect = e-109
Identities = 245/695 (35%), Positives = 372/695 (53%), Gaps = 43/695 (6%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFE--LLVSAHK 642
L+ KTV+ VTHQ+++L + D ++ +G + + G++E L+ T F LL
Sbjct: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
Query: 643 VTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPL 702
V IN + S QD K S + +++ G QL Q EEK G+V W
Sbjct: 792 VEINSKKETSGSQKKSQDKG----PKTGSVKKEKAVKPEEG-QLVQLEEKGQGSVPWSVY 846
Query: 703 WDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIG---------- 752
YI + G L +++ + S +WL+ I+ T G
Sbjct: 847 GVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMK 906
Query: 753 ----------VYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDST 802
+YAL +R L+AS+ I +PM FFD+T
Sbjct: 907 DNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT 966
Query: 803 PA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALI 855
P S D+ +D +P+ I V + +IA V L+ P ++
Sbjct: 967 PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFS 1026
Query: 856 FIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYLKLVDTDAS 915
+ + REL R++ T++P ++ + G+ T+ A+N F Y +L+D + +
Sbjct: 1027 VLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQA 1086
Query: 916 LFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIF 975
FF AM WL +R++ L+++ +IT L+I+L + P GL++SYA+ L G F
Sbjct: 1087 PFFLFTCAMRWLAVRLD-LISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQF 1145
Query: 976 WTRWFSNLSNYIISVERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPN 1034
R S SVERI +I + E PA + N P WP +G++ + E+RYR N
Sbjct: 1146 TVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYREN 1205
Query: 1035 APLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD 1094
PLVLK ++ T K ++G+VGRTGSGKS+L ALFRLVE S G I IDG+ I +GL D
Sbjct: 1206 LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1265
Query: 1095 LRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSD 1154
LR KLSIIPQEP LF G++R+NLDP Y++D+IW A+E+ +KE I++LP L+S V +
Sbjct: 1266 LRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVME 1325
Query: 1155 EGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVA 1214
G N+S+G+RQL C+ R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+A
Sbjct: 1326 NGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIA 1385
Query: 1215 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
HR+ TV+ SD +MVL+ G++VE+D PS L+ +SS
Sbjct: 1386 HRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSS 1420
Score = 85.5 bits (210), Expect = 8e-16
Identities = 64/250 (25%), Positives = 115/250 (45%), Gaps = 21/250 (8%)
Query: 1006 IVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKST 1064
++D++ PS +GK I L L ++ L I + G VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKHIHLGHLRLQR------TLHSIDLEIQEGKLVGICGSVGSGKTS 603
Query: 1065 LISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYS 1124
LISA+ + G I I G + + Q+ + ++R N+ Y
Sbjct: 604 LISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKEYD 650
Query: 1125 DDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDE 1184
++ + C L+ ++ LPS + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 1185 ATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKL 1243
+++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 1244 MDTNSSFSKL 1253
M+ N ++ +
Sbjct: 771 MNLNGDYATI 780
Score = 54.7 bits (130), Expect = 2e-06
Identities = 23/63 (36%), Positives = 40/63 (62%)
Query: 431 HESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGGTLAYVSQ 490
H + L ++LEI+ + + +C VGS K+S + AILG++ + G++ + GT AYV+Q
Sbjct: 571 HLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQ 630
Query: 491 SSW 493
+W
Sbjct: 631 QAW 633
>MRP2_RAT (Q63120) Canalicular multispecific organic anion transporter
1 (ATP-binding cassette, sub-family C, member 2)
(Multidrug resistance-associated protein 2) (Canalicular
multidrug resistance protein)
Length = 1541
Score = 394 bits (1013), Expect = e-109
Identities = 211/513 (41%), Positives = 313/513 (60%), Gaps = 9/513 (1%)
Query: 751 IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA------ 804
IGV+ L ++ + + + ++ AS A T+I APM FFD+TP
Sbjct: 1020 IGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNR 1079
Query: 805 -SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQA 863
S D+S +D +P +L + + + +I T I+ +P + I +Q +Y A
Sbjct: 1080 FSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVA 1139
Query: 864 TARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVA 923
T+R+L R++ TK+P+ + +ET G+ +RAF RF K +D + F +
Sbjct: 1140 TSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITS 1199
Query: 924 MEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNL 983
WL +R+E + NL V +ALLL++ ++ L+ VG LS AL + + R S
Sbjct: 1200 NRWLAIRLELVGNLVVFCSALLLVIY-RKTLTGDVVGFVLSNALNITQTLNWLVRMTSEA 1258
Query: 984 SNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGIT 1043
I++VERI ++I++ E P + D RPP+ WP G+I +VRYRP LVLKGIT
Sbjct: 1259 ETNIVAVERISEYINVENEAPWVTDK-RPPADWPRHGEIQFNNYQVRYRPELDLVLKGIT 1317
Query: 1044 CTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIP 1103
C K G +VGVVGRTG+GKS+L + LFR++E + G I+IDGI++ S+GL DLR +L+IIP
Sbjct: 1318 CNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIP 1377
Query: 1104 QEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQ 1163
Q+P LF GS+R NLDP YSD+E+W+A+E L+ +S L L S V++ G N S+GQ
Sbjct: 1378 QDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQ 1437
Query: 1164 RQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDS 1223
RQL CLGR +L++++ILVLDEATA++D TD+++Q IR+EF +CTVIT+AHR+ T++DS
Sbjct: 1438 RQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDS 1497
Query: 1224 DMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 1256
D +MVL GK+VEY P +L+ SF + E
Sbjct: 1498 DKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKE 1530
Score = 75.5 bits (184), Expect = 9e-13
Identities = 95/455 (20%), Positives = 184/455 (39%), Gaps = 46/455 (10%)
Query: 827 IEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAET 886
I++ + IF + ++ V MV LI + R + N K + E
Sbjct: 442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEI 501
Query: 887 HLGVVTVRAFNMVDRF-----------FKNYLKLVDTDASLFFHSNVAMEWLVLRIEALL 935
G+ ++ F F KN L+ + L F +L+I +L
Sbjct: 502 LSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIF---------ILQITPIL 552
Query: 936 NLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQ 995
++V+T ++ +++ L+ + S++ L S++ +SV+R+++
Sbjct: 553 -VSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLER 611
Query: 996 FIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVV 1055
++ + + R S++ K + P+ ++ + K G V VV
Sbjct: 612 YLGGDDLDTSAI---RRVSNFDKAVKFSEASFT--WDPDLEATIQDVNLDIKPGQLVAVV 666
Query: 1056 GRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRT 1115
G GSGKS+L+SA+ +E G I I G + +PQ+ + G+I+
Sbjct: 667 GTVGSGKSSLVSAMLGEMENVHGHITIQG-------------STAYVPQQSWIQNGTIKD 713
Query: 1116 NLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLK 1175
N+ Y++ + + ++ C L + LP + + ++G N S GQ+Q L R +
Sbjct: 714 NILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQ 773
Query: 1176 RNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYG 1232
I +LD+ +++D+ I +++ T I V H + + D ++VL G
Sbjct: 774 DADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKG 833
Query: 1233 KLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSLP 1267
++E L+D F A W + K+S P
Sbjct: 834 TILEKGSYRDLLDKKGVF----ARNWKTFMKHSGP 864
Score = 63.2 bits (152), Expect = 4e-09
Identities = 31/75 (41%), Positives = 48/75 (63%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A++ + +F WD + + ++DVNL+IK Q +AV VGS KSS + A+LGE+ + G
Sbjct: 632 AVKFSEASFTWDPD-LEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGH 690
Query: 479 VYVGGTLAYVSQSSW 493
+ + G+ AYV Q SW
Sbjct: 691 ITIQGSTAYVPQQSW 705
Score = 35.4 bits (80), Expect = 1.00
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 3/46 (6%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
L KT I VTH + FL +VD I+ G +++ GSY +LL F
Sbjct: 806 LAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVF 851
>MRP3_HUMAN (O15438) Canalicular multispecific organic anion
transporter 2 (Multidrug resistance-associated protein 3)
(Multi-specific organic anion tranporter-D) (MOAT-D)
Length = 1527
Score = 392 bits (1008), Expect = e-108
Identities = 250/722 (34%), Positives = 381/722 (52%), Gaps = 67/722 (9%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLK------------------- 629
L KT +LVTH + FL + D I+ DG+V + G Y LL+
Sbjct: 800 LAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQG 859
Query: 630 ----SGTAFE-------LLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGE---- 674
S TA E LL+ DL N V Q L+ S+GE
Sbjct: 860 HLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGR 919
Query: 675 ------------ISSIQGSIGAQLTQEEEKVIGNVGWKPLWDYINYSN--GTLMSCLVIL 720
+ + LTQEE+ IG V WDY TL CL+ +
Sbjct: 920 PVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYV 979
Query: 721 GQCCFLALQTSSNFWLAT----AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALL 775
GQ A +N WL+ A+ + +T+L +GVYA L I V + + A
Sbjct: 980 GQS---AAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAG 1036
Query: 776 GLKASTAFFSSFTTSIFNAPMLFFDSTPASSDLSILDFDIPYSLTCVAIVAIEVLVMIF- 834
G++A+ + + +P FFD+TP+ L+ DI +A V + +L F
Sbjct: 1037 GIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFN 1096
Query: 835 ------VIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHL 888
VI + T +V +P V +Q++Y AT+R+L R+ +++P+ + +ET
Sbjct: 1097 AISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVT 1156
Query: 889 GVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLIL 948
G +RA+N F VD + + ++ WL + +E + N V+ AAL ++
Sbjct: 1157 GASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVI 1216
Query: 949 LPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVD 1008
+ L+PG VGLS+SY+L + A + R S+L + I++VER+K++ E P +V+
Sbjct: 1217 -GRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE 1275
Query: 1009 NNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISA 1068
+RPP WP +G+++ + VRYRP LVL+ ++ GG +VG+VGRTG+GKS++
Sbjct: 1276 GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLC 1335
Query: 1069 LFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEI 1128
LFR++E ++G+I IDG+N+ +GL DLR +L+IIPQ+P LF G++R NLDP G YS+++I
Sbjct: 1336 LFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDI 1395
Query: 1129 WKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATAS 1188
W A+E L +S P+ LD S+ G N S+GQRQL CL R LL+++RILVLDEATA+
Sbjct: 1396 WWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAA 1455
Query: 1189 IDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNS 1248
ID TD ++Q IR +F+ CTV+T+AHR+ T++D V+VL G + E+D P+ L+
Sbjct: 1456 IDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
Query: 1249 SF 1250
F
Sbjct: 1516 IF 1517
Score = 86.7 bits (213), Expect = 4e-16
Identities = 93/426 (21%), Positives = 176/426 (40%), Gaps = 28/426 (6%)
Query: 835 VIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVR 894
V+A V + VL++ + VA+ + +Q +L + ++N L
Sbjct: 452 VLAGVAFMVLLIPLNGAVAVKM--RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS 509
Query: 895 AFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYL 954
V+ + L+L+ T A + H+ W+ + +T+IT + + + P L
Sbjct: 510 FLKQVEGIRQGELQLLRTAA--YLHTTTTFTWMC----SPFLVTLITLWVYVYVDPNNVL 563
Query: 955 SPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPS 1014
+ +S+S L + SNL+ +S++RI+QF+ P V+
Sbjct: 564 DAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP 623
Query: 1015 SWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVE 1074
+ I + + + P L + G+ V VVG G GKS+L+SAL +E
Sbjct: 624 GYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEME 679
Query: 1075 PSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEK 1134
G + + G ++ +PQ+ + +++ N+ + + +E
Sbjct: 680 KLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEA 726
Query: 1135 CQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-AT 1193
C L + LP + + ++G N S GQRQ L R + I +LD+ +++DS
Sbjct: 727 CALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVA 786
Query: 1194 DAILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFS 1251
I +I E T + V H + + +D ++VL+ G++ E L+ N SF+
Sbjct: 787 KHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFA 846
Query: 1252 KLVAEY 1257
+ Y
Sbjct: 847 NFLCNY 852
Score = 61.6 bits (148), Expect = 1e-08
Identities = 29/75 (38%), Positives = 47/75 (62%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+ I GTF W + + P L +++++ +AV PVG KSS + A+LGE+ K+ G
Sbjct: 626 AITIHSGTFTWAQD-LPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGK 684
Query: 479 VYVGGTLAYVSQSSW 493
V++ G++AYV Q +W
Sbjct: 685 VHMKGSVAYVPQQAW 699
>YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium
factor 1)
Length = 1515
Score = 390 bits (1002), Expect = e-107
Identities = 248/717 (34%), Positives = 382/717 (52%), Gaps = 49/717 (6%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTA--FELLVSAHKVT-- 644
L KT +L T++V LS D+I +G++ Q G+Y+ + K + ++LL + K
Sbjct: 802 LHTKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNG 861
Query: 645 -INDLNQNSEVL----SNPQDSHGFYLTK---------------NQSEGEISSIQGSIGA 684
N+ +SE S P + L K S+ + SI
Sbjct: 862 KSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAISLRRASDATLGSIDFGDDE 921
Query: 685 QLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEI-- 742
+ + E + G V W +Y N + C+ IL + L N WL E+
Sbjct: 922 NIAKREHREQGKVKWNIYLEYAKACNPKSV-CVFILFIVISMFLSVMGNVWLKHWSEVNS 980
Query: 743 ---PKVTDTTLIGVYALLSISSTSFVYVRSYFA-ALLGLKASTAFFSSFTTSIFNAPMLF 798
+ +Y L I S +++ + AS + T S+ APM F
Sbjct: 981 RYGSNPNAARYLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTF 1040
Query: 799 FDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAM 851
F++TP S+D+ +D + + + + A++V I VI + TWQ + + +P
Sbjct: 1041 FETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLS 1100
Query: 852 VALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYLKLVD 911
V I+ Q+YY T+REL R++ T++P+ + ET G+ TVR ++ RF +D
Sbjct: 1101 VFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRID 1160
Query: 912 TDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLIL-LPQRYLSPGRVGLSLSYALTLN 970
+ S F+ S A WL R+E + ++ ++ AA L + L Q L+ G VGLSLSYAL +
Sbjct: 1161 NNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQIT 1220
Query: 971 GAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVR 1030
+ R + I+SVERIK++ + +E P IV+ +RPP WPS+G I R
Sbjct: 1221 QTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYSTR 1280
Query: 1031 YRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSM 1090
YRP LVLK I K +VG+VGRTG+GKS+L ALFR++E S G+I+ID I I +
Sbjct: 1281 YRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEI 1340
Query: 1091 GLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKE-TISKLPSLLD 1149
GL DLR KLSIIPQ+ +F+G++R N+DP+ Y+D+ IW+A+E LKE +S LD
Sbjct: 1341 GLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLD 1400
Query: 1150 SSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECT 1209
+ +++ GGN S+GQRQL CL R +L ++ILVLDEATA++D TD ++Q IR F++ T
Sbjct: 1401 AQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRT 1460
Query: 1210 VITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSL 1266
++T+AHR+ T++DSD ++VL GK+ E+D P +L+ N S ++S C + L
Sbjct: 1461 ILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSL------FYSLCMEAGL 1511
Score = 57.0 bits (136), Expect = 3e-07
Identities = 52/232 (22%), Positives = 103/232 (43%), Gaps = 21/232 (9%)
Query: 1032 RPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMG 1091
+P + LK I K G+ +VG+ GSGK+ L+S + GD+ G
Sbjct: 639 KPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCML-------GDL------FRVKG 685
Query: 1092 LKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSS 1151
+ ++ + Q P + G+++ N+ Y + K ++ C L ++ L +
Sbjct: 686 FATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTL 745
Query: 1152 VSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-ATDAILQRIIRQE--FEEC 1208
V ++G + S GQ+ L R + R +LD+ A++D +++ ++
Sbjct: 746 VGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTK 805
Query: 1209 TVITVAHRVPTVIDSDMVMVLSYGKLVE---YDEPSKLMDTNSSFSKLVAEY 1257
T + ++V + +D + +L G++ + YDE +K D +S KL+ Y
Sbjct: 806 TKVLATNKVSALSIADSIALLDNGEITQQGTYDEITK--DADSPLWKLLNNY 855
Score = 51.2 bits (121), Expect = 2e-05
Identities = 28/85 (32%), Positives = 46/85 (53%), Gaps = 3/85 (3%)
Query: 410 KNLTQCSVNALQIQDGTFIWDHE-SMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAI 468
KN+ ++N D TF+W + ALK++N + K + VGS K++ L +
Sbjct: 619 KNIGDVAINIGD--DATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCM 676
Query: 469 LGEIPKISGTVYVGGTLAYVSQSSW 493
LG++ ++ G V G++AYVSQ W
Sbjct: 677 LGDLFRVKGFATVHGSVAYVSQVPW 701
>MRP3_RAT (O88563) Canalicular multispecific organic anion transporter
2 (Multidrug resistance-associated protein 3) (MRP-like
protein-2) (MLP-2)
Length = 1522
Score = 389 bits (998), Expect = e-107
Identities = 244/720 (33%), Positives = 387/720 (52%), Gaps = 66/720 (9%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLV---------S 639
L KT +LVTH + FL + D I+ DG++ + G Y LL+ +F +
Sbjct: 798 LAGKTRVLVTHGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQE 857
Query: 640 AHKVTINDLNQNSEVLSNPQDSH--------GFYLTKNQ---------SEGE-------- 674
A++ + N+ +L + +H Y + Q SEGE
Sbjct: 858 ANEGVLQHANEEVLLLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLK 917
Query: 675 --ISSIQGSIGAQLTQEEEKVI-------GNVGWKPLWDYINYSN--GTLMSCLVILGQC 723
SS++ + A T+E +I GNV WDY TL CL+ GQ
Sbjct: 918 RYTSSLEKEVPATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQN 977
Query: 724 CFLALQTSSNFWLAT----AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALLGLK 778
A+ +N WL+ E + +T++ +GVYA L I V + ++ + ++
Sbjct: 978 ---AVAIGANVWLSAWTNDVEEHGQQNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQ 1034
Query: 779 ASTAFFSSFTTSIFNAPMLFFDSTPASSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIAS 838
A+ ++ + AP FFD+TP+ L+ DI Y + V I +L F +
Sbjct: 1035 AARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDI-YVIHEVLAPTILMLFNSFYTSI 1093
Query: 839 VTWQVLIVAVPAMVALI--------FIQKYYQATARELIRINGTTKAPVMNFAAETHLGV 890
T V++ + P ++ F+Q++Y AT+R+L R+ +++P+ + +ET G
Sbjct: 1094 STIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGT 1153
Query: 891 VTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLP 950
+RA+ V F VD++ + + WL + +E + N V+ +AL ++
Sbjct: 1154 SVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVI-G 1212
Query: 951 QRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNN 1010
+ L+PG VGLS+SYAL + + + R S+L + II+VER+K++ E P ++++N
Sbjct: 1213 RNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESN 1272
Query: 1011 RPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALF 1070
R P WP G ++ + VRYRP LVLK +T +GG +VG+VGRTG+GKS++ LF
Sbjct: 1273 RAPEGWPRSGVVEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLF 1332
Query: 1071 RLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWK 1130
R++E + G+I IDG+N+ +GL DLR +L+IIPQ+P LF G++R NLDP G YSD++IW+
Sbjct: 1333 RILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWR 1392
Query: 1131 AVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID 1190
+E L +S P+ LD S+ G N S+GQRQL CL R LL+++R+LVLDEATA+ID
Sbjct: 1393 TLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAID 1452
Query: 1191 SATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSF 1250
TD ++Q IR +FE+CTV+T+AHR+ T++D + V+VL G + E+D P L+ F
Sbjct: 1453 LETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIF 1512
Score = 82.0 bits (201), Expect = 9e-15
Identities = 76/325 (23%), Positives = 142/325 (43%), Gaps = 22/325 (6%)
Query: 937 LTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQF 996
+T+IT + + + L + +SLS L + S ++ +S++RI+ F
Sbjct: 544 VTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDF 603
Query: 997 IHIPAEPPAIVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVV 1055
++ P V+ S G+ I + + + P L I G+ V VV
Sbjct: 604 LNQDELDPQCVERKTI-----SPGRAITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVV 658
Query: 1056 GRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRT 1115
G G GKS+L+SAL +E G + + G ++ +PQ+ + +++
Sbjct: 659 GPVGCGKSSLVSALLGEMEKLEGAVSVKG-------------SVAYVPQQAWIQNCTLQE 705
Query: 1116 NLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLK 1175
N+ + +A+E C L + LP + + ++G N S GQRQ L R +
Sbjct: 706 NVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS 765
Query: 1176 RNRILVLDEATASIDS-ATDAILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYG 1232
I +LD+ +++DS I ++I E T + V H + + +D ++VL+ G
Sbjct: 766 DANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG 825
Query: 1233 KLVEYDEPSKLMDTNSSFSKLVAEY 1257
++ E S+L+ + SF+ + Y
Sbjct: 826 QITEMGHYSELLQHDGSFANFLRNY 850
Score = 65.1 bits (157), Expect = 1e-09
Identities = 32/75 (42%), Positives = 47/75 (62%), Gaps = 1/75 (1%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+ I +GTF W + + P L +N++I +AV PVG KSS + A+LGE+ K+ G
Sbjct: 624 AITIHNGTFSWSKD-LPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGA 682
Query: 479 VYVGGTLAYVSQSSW 493
V V G++AYV Q +W
Sbjct: 683 VSVKGSVAYVPQQAW 697
>YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c
Length = 1478
Score = 382 bits (982), Expect = e-105
Identities = 251/703 (35%), Positives = 379/703 (53%), Gaps = 51/703 (7%)
Query: 592 LRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTA--FELLVSAHKVTI- 645
LR + VIL T+ + L E I +GK+I+SGS+ L S + F+LL K
Sbjct: 770 LRSRCVILSTNSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTA 829
Query: 646 ------NDLNQNSEVLSNPQD-----SHGFYLTKNQSEGEISSIQGSIGAQLTQE----- 689
L+++ V+++ D S N + I G I +LT E
Sbjct: 830 SSTGADTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKATIKGT-GRIRKRLTDEDNVKA 888
Query: 690 -----EEKVIGNVGWKPLWDYINYSNGTLMSC--LVILGQCCFLALQTSSNFWLATAIEI 742
E+ G V WK W Y + L+ L I+G + + +N WL E+
Sbjct: 889 TGQAAEKMERGKVKWKVYWTYFKACSLFLIFLYFLFIIGG---IGMNVGTNVWLKHWSEV 945
Query: 743 -------PKVTDTTLIGVYALLSISSTSFVYVRSY-FAALLGLKASTAFFSSFTTSIFNA 794
PK +G+Y L + S + + + S +K+ S ++ A
Sbjct: 946 NTQLGYNPK--PYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRA 1003
Query: 795 PMLFFDSTPASSDLSILDFDIPYSLTCVAIVAI----EVLVMIFVIASVTWQ---VLIVA 847
PM FF++TP L+ D+ ++ V + + ++FV+A + + +I+
Sbjct: 1004 PMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILI 1063
Query: 848 VPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYL 907
VP + Q YY T+REL R++ T++P+ E+ G+ T+RA++M D F
Sbjct: 1064 VPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISEND 1123
Query: 908 KLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQR-YLSPGRVGLSLSYA 966
VDT+ ++F + W +R+EA+ L V ++A +L R + G VGLSLSYA
Sbjct: 1124 IRVDTNHRIWFLYFSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYA 1183
Query: 967 LTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQG 1026
+ + + F R ++ I+SVER+ ++I +P+E P+I+ ++RPP WPS G I
Sbjct: 1184 VQITQSLTFVVRQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHRPPEGWPSHGAIKFDH 1243
Query: 1027 LEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGIN 1086
VRYR N PLVL I+ K ++G+VGRTG+GKSTL ALFRL+EP+ GDI +D IN
Sbjct: 1244 YSVRYRENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDIN 1303
Query: 1087 ICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPS 1146
I S+GL DLR +L+IIPQE F+G+IR NLDP +D+EIW A+E LK+ I L
Sbjct: 1304 ITSIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDG 1363
Query: 1147 LLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFE 1206
L S V++ G N S GQRQL CL R LL R+L+LDEATA++D TDAI+QR IR+ F
Sbjct: 1364 GLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFN 1423
Query: 1207 ECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
+ T++T+AHR+ TV+DS+ ++VL +GK+VE+D KL++ +S
Sbjct: 1424 DRTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLENKAS 1466
Score = 54.7 bits (130), Expect = 2e-06
Identities = 50/224 (22%), Positives = 100/224 (44%), Gaps = 19/224 (8%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
L+ I + G +VG+ G GKS+L+ A ++ G + G
Sbjct: 614 LRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCG-------------S 660
Query: 1099 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIW-KAVEKCQLKETISKLPSLLDSSVSDEGG 1157
++ Q+P + +I+ N+ GL D E + K + C L L + V ++G
Sbjct: 661 IAYAAQQPWILNATIQENI-LFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGI 719
Query: 1158 NWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRII---RQEFEECTVITVA 1214
+ S GQ+ L R + R+ I +LD+ +++D + L R + + VI
Sbjct: 720 SLSGGQKARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILST 779
Query: 1215 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDT-NSSFSKLVAEY 1257
+ + + ++ M+ +L GK++E ++L + +S +L++E+
Sbjct: 780 NSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEF 823
Score = 52.4 bits (124), Expect = 8e-06
Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 420 LQIQDGTFIWD---HESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKIS 476
L+I+ GTF W + P L+D++ + + + VG KSS L A LG + K S
Sbjct: 593 LEIKKGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHS 652
Query: 477 GTVYVGGTLAYVSQSSW 493
G+V+ G++AY +Q W
Sbjct: 653 GSVFRCGSIAYAAQQPW 669
>BPT1_YEAST (P14772) Bile pigment transporter 1
Length = 1559
Score = 363 bits (932), Expect = 2e-99
Identities = 245/758 (32%), Positives = 400/758 (52%), Gaps = 82/758 (10%)
Query: 580 SCNTIQYCVM---TALRDKTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLL--KSG 631
S N I+Y ++ L++KT+IL T+ V L I +G++++ G+YE+++ K+
Sbjct: 805 SKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNN 864
Query: 632 TA-FELLVSAHKVTINDLNQNSEVLSNPQDSH-----GFYLTKNQSEGEI---------- 675
T+ + L+ I++ N++ + +S +T++++E E+
Sbjct: 865 TSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIK 924
Query: 676 -SSIQGS---------IGAQL------TQEEEKV-IGNVGWKPLWDYINYSNGTLMSCLV 718
+S + S +GAQL Q+ EK +G V K YI + G L L
Sbjct: 925 ANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIK-ACGVLGVVLF 983
Query: 719 ILGQCCFLALQTSSNFWLATAIEIPKVTDTT-----LIGVYALLSISSTSFVYVRSYFAA 773
L + NFWL E + + +GVY+L+ ++S +F +RS
Sbjct: 984 FLFMILTRVFDLAENFWLKYWSESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMML 1043
Query: 774 LL-GLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIV 825
L ++ S S S+ +PM FF++TP SSD+ +D ++ Y +
Sbjct: 1044 LYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKS 1103
Query: 826 AIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAE 885
+ LV + ++ L+ + +V I+ Q +Y +REL R+ + +P+M+ +E
Sbjct: 1104 ILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSE 1163
Query: 886 THLGVVTVRAFNMVDRF-FKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAAL 944
+ G + A++ +RF + NY K + + F+ WL +R++ + V+ A+
Sbjct: 1164 SLNGYSIIDAYDHFERFIYLNYEK-IQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAI 1222
Query: 945 LLI--LLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAE 1002
L + + +R LS G VGL +SY+L + G+ + R + I+SVERI ++ +P E
Sbjct: 1223 LALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPE 1282
Query: 1003 PPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGK 1062
+I RP +WPSKG I+ + +YR N VL I + +VG+VGRTG+GK
Sbjct: 1283 AQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGK 1342
Query: 1063 STLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGL 1122
STL ALFR++EP+ G I+IDGI+I +GL DLR L+IIPQ+ F+G+++TNLDP
Sbjct: 1343 STLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNR 1402
Query: 1123 YSDDEIWKAVEKCQLKETISKL-----------------PSLLDSSVSDEGGNWSLGQRQ 1165
YS+DE+ +AVE+ LK + K+ +LD +++ G N S+GQRQ
Sbjct: 1403 YSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQ 1462
Query: 1166 LFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDM 1225
L CL R LL R++ILVLDEATAS+D TD I+Q IR+EF++ T++T+AHR+ TV+DSD
Sbjct: 1463 LLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDK 1522
Query: 1226 VMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSSCRK 1263
++VL G + E+D PSKL+ +S ++S C K
Sbjct: 1523 IIVLDQGSVREFDSPSKLLSDKTSI------FYSLCEK 1554
Score = 65.9 bits (159), Expect = 7e-10
Identities = 86/367 (23%), Positives = 148/367 (39%), Gaps = 51/367 (13%)
Query: 945 LLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPP 1004
L L LSP V SLS LN A + + +S+ER+K F+
Sbjct: 538 LFSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDD 597
Query: 1005 AIVDNNRPPSS---------------WPSKGKI-------DLQGLEVRYRPNAPLVLKGI 1042
+ ++ P + W SK + +L+ E ++ + LK I
Sbjct: 598 SFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNI 657
Query: 1043 T-CTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD-LRMKLS 1100
K G V VVGR G+GKST + A+ G C G +D + KL
Sbjct: 658 DHFEAKRGDLVCVVGRVGAGKSTFLKAIL-------------GQLPCMSGSRDSIPPKLI 704
Query: 1101 I-------IPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVS 1153
I QE + S+R N+ + D ++ CQL + LP ++ V
Sbjct: 705 IRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVG 764
Query: 1154 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-ATDAILQRIIRQE---FEECT 1209
++G + S GQ+ L R + R I +LD+ +++D+ + I++ ++ + + T
Sbjct: 765 EKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKT 824
Query: 1210 VITVAHRVPTVIDSDMVMVLSYGKLVE---YDEPSKLMDTNSSFSKLVAEYWSSCRKNSL 1266
+I + V + S M+ L G++VE Y++ + S KL+ E+ S +
Sbjct: 825 IILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNE 884
Query: 1267 PYISKKH 1273
+ +H
Sbjct: 885 SDVQTEH 891
Score = 40.4 bits (93), Expect = 0.031
Identities = 25/66 (37%), Positives = 38/66 (56%), Gaps = 9/66 (13%)
Query: 437 ALKDVN-LEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT--------VYVGGTLAY 487
ALK+++ E K + V VG+ KS+FL AILG++P +SG+ + ++AY
Sbjct: 653 ALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAY 712
Query: 488 VSQSSW 493
SQ SW
Sbjct: 713 CSQESW 718
>ACC9_MOUSE (P70170) Sulfonylurea receptor 2
Length = 1546
Score = 352 bits (904), Expect = 3e-96
Identities = 237/709 (33%), Positives = 383/709 (53%), Gaps = 44/709 (6%)
Query: 580 SCNTIQYCVMTALRD--KTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
S + +Q ++ L+D +TV+LVTH++++L+ D I+ DG V++ G+ LK
Sbjct: 844 SDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGT----LKDIQTK 899
Query: 635 ELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--- 691
++ + H T+ +N+ + L ++ L + + S + + EEE
Sbjct: 900 DVELYEHWKTL--MNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 957
Query: 692 -----------KVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLAT-- 738
++ + WK W Y+ S G + L+I + ++ + ++WLAT
Sbjct: 958 EDEEDNMSTVMRLRTKMPWKTCWWYLT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWT 1016
Query: 739 ---AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNA 794
+I P D T + +++L + V S +GL A+ + I
Sbjct: 1017 SEYSINHPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1076
Query: 795 PMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVA 847
P+ FFD+TP S+D +I+D IP +L + + L I +I+ T L+
Sbjct: 1077 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVAL 1136
Query: 848 VPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYL 907
P VA FIQKY++ +++L ++ +T+ P++ +ET G+ T+RAF RF + L
Sbjct: 1137 APLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1196
Query: 908 KLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYAL 967
+L DT+ + + A WL +R + L V+TA++ I + G VGL L YAL
Sbjct: 1197 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI---SGSSNSGLVGLGLLYAL 1253
Query: 968 TLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQG 1026
T+ + R ++L + +V+++ F+ + +E +D ++ P WP +G+I +
Sbjct: 1254 TITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHD 1313
Query: 1027 LEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGIN 1086
L VRY N VLK + K G +VG+ GRTGSGKS+L A FR+V+ G I+IDGI+
Sbjct: 1314 LCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGID 1373
Query: 1087 ICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPS 1146
I + L LR +LSII Q+P LF GSIR NLDP +DD +W+A+E QLK + LP
Sbjct: 1374 ISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPG 1433
Query: 1147 LLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFE 1206
LD++V++ G N+S+GQRQLFCL R ++++ IL++DEATASID AT+ ILQ+++ F
Sbjct: 1434 GLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFA 1493
Query: 1207 ECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDE-PSKLMDTNSSFSKLV 1254
+ TV+T+AHRV +++D+ +V+V S G LVE D P+ L N FS LV
Sbjct: 1494 DRTVVTIAHRVSSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLV 1542
Score = 68.2 bits (165), Expect = 1e-10
Identities = 50/205 (24%), Positives = 100/205 (48%), Gaps = 9/205 (4%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
L I G +VG+ G GKS+L+ A+ ++ G + + +N + R +
Sbjct: 685 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSR 744
Query: 1099 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 1153
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 745 SRYSVAYAAQKPWLLNATVEENIT-FGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIG 803
Query: 1154 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 1210
+ G N S GQRQ C+ R L + I+ LD+ +++D +D ++Q I + + ++ TV
Sbjct: 804 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTV 863
Query: 1211 ITVAHRVPTVIDSDMVMVLSYGKLV 1235
+ V H++ + +D ++ + G ++
Sbjct: 864 VLVTHKLQYLTHADWIIAMKDGSVL 888
Score = 38.5 bits (88), Expect = 0.12
Identities = 22/62 (35%), Positives = 33/62 (52%), Gaps = 2/62 (3%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+++ +G F W S L ++++ I Q + VG KSS L AILGE+ + G
Sbjct: 668 AIKVTNGYFSWG--SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK 725
Query: 479 VY 480
VY
Sbjct: 726 VY 727
Score = 34.3 bits (77), Expect = 2.2
Identities = 17/51 (33%), Positives = 24/51 (46%)
Query: 433 SMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGG 483
++ P LK V IK QK+ +C GS KSS A + G + + G
Sbjct: 1321 NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1371
>ACC9_RAT (Q63563) Sulfonylurea receptor 2
Length = 1545
Score = 352 bits (903), Expect = 4e-96
Identities = 238/709 (33%), Positives = 383/709 (53%), Gaps = 44/709 (6%)
Query: 580 SCNTIQYCVMTALRD--KTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
S + +Q ++ L+D +TV+LVTH++++L+ D I+ DG V++ G+ LK
Sbjct: 843 SDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGT----LKDIQTK 898
Query: 635 ELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--- 691
++ + H T+ +N+ + L ++ L + + S + + EEE
Sbjct: 899 DVELYEHWKTL--MNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 956
Query: 692 -----------KVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLAT-- 738
++ + WK W Y+ S G + L+I + ++ + ++WLAT
Sbjct: 957 EDEDDNMSTVMRLRTKMPWKTCWWYLT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWT 1015
Query: 739 ---AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNA 794
+I P D T + +++L + V S +GL A+ + I
Sbjct: 1016 SEYSINDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1075
Query: 795 PMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVA 847
P+ FFD+TP S+D +I+D IP +L + + L I +I+ T LI
Sbjct: 1076 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIAL 1135
Query: 848 VPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYL 907
P VA FIQKY++ +++L ++ +T+ P++ +ET G+ T+RAF RF + L
Sbjct: 1136 APLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1195
Query: 908 KLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYAL 967
+L DT+ + + A WL +R + L V+TA++ I + G VGL L YAL
Sbjct: 1196 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI---SGSSNSGLVGLGLLYAL 1252
Query: 968 TLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQG 1026
T+ + R ++L + +V+++ F+ + +E +D ++ P WP +G+I +
Sbjct: 1253 TITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHD 1312
Query: 1027 LEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGIN 1086
L VRY N VLK + K G +VG+ GRTGSGKS+L A FR+V+ G I+IDGI+
Sbjct: 1313 LCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGID 1372
Query: 1087 ICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPS 1146
I + L LR +LSII Q+P LF GSIR NLDP +DD +W+A+E QLK + LP
Sbjct: 1373 ISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPG 1432
Query: 1147 LLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFE 1206
LD++V++ G N+S+GQRQLFCL R ++++ IL++DEATASID AT+ ILQ+++ F
Sbjct: 1433 GLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFA 1492
Query: 1207 ECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDE-PSKLMDTNSSFSKLV 1254
+ TV+T+AHRV +++D+ +V+V S G LVE D P+ L N FS LV
Sbjct: 1493 DRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLV 1541
Score = 68.6 bits (166), Expect = 1e-10
Identities = 50/205 (24%), Positives = 100/205 (48%), Gaps = 9/205 (4%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
L I G +VG+ G GKS+L+ A+ ++ G + + +N + R +
Sbjct: 684 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSR 743
Query: 1099 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 1153
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 744 SRYSVAYAAQKPWLLNATVEENIT-FGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIG 802
Query: 1154 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 1210
+ G N S GQRQ C+ R L + I+ LD+ +++D +D ++Q I + + ++ TV
Sbjct: 803 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTV 862
Query: 1211 ITVAHRVPTVIDSDMVMVLSYGKLV 1235
+ V H++ + +D ++ + G ++
Sbjct: 863 VLVTHKLQYLTHADWIIAMKDGSVL 887
Score = 38.5 bits (88), Expect = 0.12
Identities = 22/62 (35%), Positives = 33/62 (52%), Gaps = 2/62 (3%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+++ +G F W S L ++++ I Q + VG KSS L AILGE+ + G
Sbjct: 667 AIKVTNGYFSWG--SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK 724
Query: 479 VY 480
VY
Sbjct: 725 VY 726
Score = 34.3 bits (77), Expect = 2.2
Identities = 17/51 (33%), Positives = 24/51 (46%)
Query: 433 SMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGG 483
++ P LK V IK QK+ +C GS KSS A + G + + G
Sbjct: 1320 NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1370
>ACC8_RAT (Q09429) Sulfonylurea receptor 1
Length = 1581
Score = 351 bits (901), Expect = 6e-96
Identities = 242/720 (33%), Positives = 379/720 (52%), Gaps = 62/720 (8%)
Query: 580 SCNTIQYCVMTALRD--KTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
S + +Q ++ LRD +TV+LVTH++++L D I+ DG + + G+ ++ +S
Sbjct: 864 SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQ- 922
Query: 635 ELLVSAHKVTINDLNQNSE---VLSN--PQDSHGFYLTKNQSEGEISSIQGSIGAQLTQE 689
L K +N +Q E V+ P+ S G + +G + E
Sbjct: 923 --LFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESE 980
Query: 690 EEKVIGNV-------GWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEI 742
E+ + +V W+ Y++ S G L+ L++ Q + + ++WLA
Sbjct: 981 EDDNLSSVLHQRAKIPWRACTKYLS-SAGILLLSLLVFSQLLKHMVLVAIDYWLA----- 1034
Query: 743 PKVTDTTLI------------------GVYAL----LSISSTSFVYVRSYFAALLGLKAS 780
K TD+ L+ VYA+ L + V S GLK +
Sbjct: 1035 -KWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVA 1093
Query: 781 TAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMI 833
S I APM FF++TP SSD + +D IP +L C++ + + +
Sbjct: 1094 KRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSAL 1153
Query: 834 FVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTV 893
VI+ VT L+ +P V FIQKY++ +R+L +++ TT+ P+++ AET G+ T+
Sbjct: 1154 AVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1213
Query: 894 RAFNMVDRFFKNYLKLVDTD--ASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLP- 950
RAF RF + L+ D++ ASLF A WL +R+E + V+ AA I
Sbjct: 1214 RAFRYEARFQQKLLEYTDSNNIASLFL--TAANRWLEVRMEYIGACVVLIAAATSISNSL 1271
Query: 951 QRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDN 1009
R LS G VGL L+YAL ++ + R +++ + +V+RI + AE ++
Sbjct: 1272 HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAP 1331
Query: 1010 NRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISAL 1069
+ P +WP +GKI +Q L VRY + VLK + G ++G+ GRTGSGKS+ A
Sbjct: 1332 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAF 1391
Query: 1070 FRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIW 1129
FR+V+ G I+IDGI+I + L LR +LSII Q+P LF G+IR NLDP SD +W
Sbjct: 1392 FRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLW 1451
Query: 1130 KAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASI 1189
+A+E QLK + LP LD+ +++ G N+S GQRQLFCL R +++ I ++DEATASI
Sbjct: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
Query: 1190 DSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
D AT+ ILQ+++ F + TV+T+AHRV T++ +D+VMVL G ++E+D+P KL+ S
Sbjct: 1512 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDS 1571
Score = 57.8 bits (138), Expect = 2e-07
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 21/247 (8%)
Query: 1031 YRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSM 1090
+ P+ L IT G +VG+ G GKS+L+ A ++ G + + S
Sbjct: 687 WTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSE 746
Query: 1091 GL------------KDLRMK--LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQ 1136
G D R + ++ Q+P L ++ N+ ++ +E C
Sbjct: 747 GEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACS 806
Query: 1137 LKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDA 1195
L+ I LP + + + G N S GQRQ + R L + ++ LD+ +++D +D
Sbjct: 807 LQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDH 866
Query: 1196 ILQRIIRQ--EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKL 1253
++Q I + ++ TV+ V H++ + +D ++ + G + L D S +L
Sbjct: 867 LMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI---QREGTLKDFQRSECQL 923
Query: 1254 VAEYWSS 1260
E+W +
Sbjct: 924 F-EHWKT 929
Score = 42.7 bits (99), Expect = 0.006
Identities = 24/66 (36%), Positives = 35/66 (52%), Gaps = 1/66 (1%)
Query: 420 LQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTV 479
+QI G F W + + P L ++ + I Q + VG KSS L A LGE+ K+SG V
Sbjct: 678 VQIIGGFFTWTPDGI-PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAV 736
Query: 480 YVGGTL 485
+ +L
Sbjct: 737 FWNSSL 742
Score = 41.2 bits (95), Expect = 0.018
Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 420 LQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTV 479
+QIQ+ + +D S+ P LK VN I QKI +C GS KSSF A + G +
Sbjct: 1344 IQIQNLSVRYD-SSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRI 1402
Query: 480 YVGG 483
+ G
Sbjct: 1403 IIDG 1406
>ACC9_RABIT (P82451) Sulfonylurea receptor 2
Length = 1549
Score = 349 bits (896), Expect = 2e-95
Identities = 235/709 (33%), Positives = 380/709 (53%), Gaps = 44/709 (6%)
Query: 580 SCNTIQYCVMTALRD--KTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
S + +Q ++ L+D +T++LVTH++++L+ D I+ DG V++ G+ LK
Sbjct: 847 SDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGT----LKDIQTK 902
Query: 635 ELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--- 691
++ + H T+ +N+ + L ++ L + + S + + EEE
Sbjct: 903 DVELYEHWKTL--MNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 692 -----------KVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAI 740
++ + WK W Y+ S G + L+I + ++ + ++WLAT
Sbjct: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWT 1019
Query: 741 E------IPKVTDTTLIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNA 794
K T + +++L + V S +GL A+ + I
Sbjct: 1020 SEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1079
Query: 795 PMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVA 847
P+ FFD+TP S+D +I+D IP +L + + L I +I+ T L+
Sbjct: 1080 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVAL 1139
Query: 848 VPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFNMVDRFFKNYL 907
VP VA FIQKY++ +++L ++ +T+ P++ +ET G+ T+RAF RF + L
Sbjct: 1140 VPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRML 1199
Query: 908 KLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYAL 967
+L DT+ + + A WL +R + L V+TA++ I + G VGL L YAL
Sbjct: 1200 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI---SGSSNSGLVGLGLLYAL 1256
Query: 968 TLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQG 1026
T+ + R ++L + +V+++ F+ + +E +D ++ P WP +G+I +
Sbjct: 1257 TITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHD 1316
Query: 1027 LEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGIN 1086
L VRY N VLK + K G +VG+ GRTGSGKS+L A FR+V+ G I+IDGI+
Sbjct: 1317 LCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGID 1376
Query: 1087 ICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPS 1146
I + L LR +LSII Q+P LF GSIR NLDP +DD +W+A+E QLK + L
Sbjct: 1377 ISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLSG 1436
Query: 1147 LLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFE 1206
LD+ V++ G N+S+GQRQLFCL R ++++ IL++DEATASID AT+ ILQ+++ F
Sbjct: 1437 GLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFA 1496
Query: 1207 ECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDE-PSKLMDTNSSFSKLV 1254
+ TV+T+AHRV +++D+D+V+V S G LVE D P+ L N FS LV
Sbjct: 1497 DRTVVTIAHRVSSIVDADLVLVFSEGILVECDTGPNLLTHKNGLFSTLV 1545
Score = 62.0 bits (149), Expect = 1e-08
Identities = 47/205 (22%), Positives = 98/205 (46%), Gaps = 9/205 (4%)
Query: 1039 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 1098
L I G +VG+ G GKS+L+ A+ ++ G + +N + R +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLDGKVHWSNVNESEPSFEATRSR 747
Query: 1099 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 1153
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENIT-FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 1154 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 1210
+ G N S GQ + C+ R L + I+ LD+ +++D +D ++Q I + + ++ T+
Sbjct: 807 ERGINLSGGQTERICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 1211 ITVAHRVPTVIDSDMVMVLSYGKLV 1235
+ V H++ + +D ++ + G ++
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVL 891
Score = 38.1 bits (87), Expect = 0.15
Identities = 21/62 (33%), Positives = 34/62 (53%), Gaps = 2/62 (3%)
Query: 419 ALQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGT 478
A+++ +G F W S + L ++++ I Q + VG KSS L AILGE+ + G
Sbjct: 671 AIKVTNGCFSWG--SGAATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLDGK 728
Query: 479 VY 480
V+
Sbjct: 729 VH 730
Score = 34.3 bits (77), Expect = 2.2
Identities = 17/51 (33%), Positives = 24/51 (46%)
Query: 433 SMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTVYVGG 483
++ P LK V IK QK+ +C GS KSS A + G + + G
Sbjct: 1324 NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1374
>ACC8_HUMAN (Q09428) Sulfonylurea receptor 1
Length = 1580
Score = 348 bits (893), Expect = 5e-95
Identities = 235/716 (32%), Positives = 375/716 (51%), Gaps = 54/716 (7%)
Query: 580 SCNTIQYCVMTALRD--KTVILVTHQVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF 634
S + +Q ++ LRD +TV+LVTH++++L D I+ DG + + G+ ++ +S
Sbjct: 863 SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQL 922
Query: 635 -----------ELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEI---SSIQG 680
+ + VT + + LS S L + E E S
Sbjct: 923 FEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDD 982
Query: 681 SIGAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLA--- 737
++ + L Q E + W+ Y++ S G L+ L++ Q + + ++WLA
Sbjct: 983 NLSSMLHQRAE-----IPWRACAKYLS-SAGILLLSLLVFSQLLKHMVLVAIDYWLAKWT 1036
Query: 738 -TAIEIPKVT------------DTTLIGVYALLSISSTSFVYVRSYFAALLGLKASTAFF 784
+A+ + T V+ +L V S GLK +
Sbjct: 1037 DSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLH 1096
Query: 785 SSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIA 837
S I APM FF++TP SSD + +D IP +L C++ + + + VI+
Sbjct: 1097 RSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVIS 1156
Query: 838 SVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETHLGVVTVRAFN 897
VT L+ +P + FIQKY++ +R+L +++ TT+ P+++ AET G+ T+RAF
Sbjct: 1157 YVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFR 1216
Query: 898 MVDRFFKNYLKLVDTD--ASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLP-QRYL 954
RF + L+ D++ ASLF A WL +R+E + V+ AA+ I R L
Sbjct: 1217 YEARFQQKLLEYTDSNNIASLFL--TAANRWLEVRMEYIGACVVLIAAVTSISNSLHREL 1274
Query: 955 SPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPP 1013
S G VGL L+YAL ++ + R +++ + +V+RI + AE ++ + P
Sbjct: 1275 SAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIP 1334
Query: 1014 SSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLV 1073
+WP +GKI +Q L VRY + VLK + G ++G+ GRTGSGKS+ A FR+V
Sbjct: 1335 KNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMV 1394
Query: 1074 EPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVE 1133
+ G I+IDGI+I + L LR +LSII Q+P LF G+IR NLDP SD +W+A+E
Sbjct: 1395 DTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALE 1454
Query: 1134 KCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSAT 1193
QLK + LP LD+ +++ G N+S GQRQLFCL R +++ I ++DEATASID AT
Sbjct: 1455 IAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMAT 1514
Query: 1194 DAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 1249
+ ILQ+++ F + TV+T+AHRV T++ +D+V+VL G ++E+D+P KL+ S
Sbjct: 1515 ENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1570
Score = 60.5 bits (145), Expect = 3e-08
Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 20/255 (7%)
Query: 1022 IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIL 1081
+ + G + P+ L IT G +VG+ G GKS+L+ A ++ G +
Sbjct: 678 VQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVF 737
Query: 1082 IDGINICSMGLK-----------DLRMK--LSIIPQEPTLFKGSIRTNLDPLGLYSDDEI 1128
+ +G D+R + ++ Q+P L ++ N+ ++
Sbjct: 738 WSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRY 797
Query: 1129 WKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATAS 1188
+E C L+ I LP + + + G N S GQRQ + R L + ++ LD+ ++
Sbjct: 798 KMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSA 857
Query: 1189 ID-SATDAILQRIIRQ--EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMD 1245
+D +D ++Q I + ++ TV+ V H++ + +D ++ + G + L D
Sbjct: 858 LDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI---QREGTLKD 914
Query: 1246 TNSSFSKLVAEYWSS 1260
S +L E+W +
Sbjct: 915 FQRSECQLF-EHWKT 928
Score = 43.1 bits (100), Expect = 0.005
Identities = 23/61 (37%), Positives = 33/61 (53%), Gaps = 1/61 (1%)
Query: 420 LQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTV 479
+QI G F W + + P L ++ + I Q + VG KSS L A LGE+ K+SG V
Sbjct: 678 VQIMGGYFTWTPDGI-PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAV 736
Query: 480 Y 480
+
Sbjct: 737 F 737
Score = 40.8 bits (94), Expect = 0.024
Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 420 LQIQDGTFIWDHESMSPALKDVNLEIKWRQKIAVCAPVGSEKSSFLYAILGEIPKISGTV 479
+QIQ+ + +D S+ P LK VN I QKI +C GS KSSF A + G +
Sbjct: 1343 IQIQNLSVRYD-SSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHI 1401
Query: 480 YVGG 483
+ G
Sbjct: 1402 IIDG 1405
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.346 0.150 0.508
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 127,528,582
Number of Sequences: 164201
Number of extensions: 4941950
Number of successful extensions: 28737
Number of sequences better than 10.0: 853
Number of HSP's better than 10.0 without gapping: 683
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 26022
Number of HSP's gapped (non-prelim): 1932
length of query: 1273
length of database: 59,974,054
effective HSP length: 122
effective length of query: 1151
effective length of database: 39,941,532
effective search space: 45972703332
effective search space used: 45972703332
T: 11
A: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 38 (21.7 bits)
S2: 72 (32.3 bits)
Medicago: description of AC119410.2