BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC087771.6 + phase: 0 /pseudo/partial
(461 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 272 2e-72
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 268 2e-71
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 265 2e-70
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 256 7e-68
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 253 6e-67
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 250 5e-66
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 250 6e-66
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 250 6e-66
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 247 4e-65
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 247 5e-65
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 241 3e-63
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 240 5e-63
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 238 2e-62
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 237 4e-62
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 235 2e-61
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 212 2e-54
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 196 1e-49
PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1 192 1e-48
MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprote... 186 8e-47
MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprote... 172 2e-42
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 272 bits (695), Expect = 2e-72
Identities = 167/489 (34%), Positives = 263/489 (53%), Gaps = 34/489 (6%)
Query: 4 KEGDERKKEHK-----VSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLIN 58
K G + KKE K VS+ +F +A D + M +G++ AI+HG ++P+ + FG + +
Sbjct: 17 KMGRKSKKEKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTD 76
Query: 59 VIGLAYLFPKEASHKVAKSKCSNIIFILDRGGLLDAYWRKTSSKDENGLFKVYV------ 112
P A++ + S+I L+ AY+ + L Y+
Sbjct: 77 SFASVGNIPTNATNNATQVNASDIFGKLEEEMTTYAYYY--TGIGAGVLIVAYIQVSFWC 134
Query: 113 --------KSRYKFI*Y*GIHWRGHFCYYK*HYYCSRCS-----IREG------NFLHYI 153
K R KF G F + +R + I EG F +
Sbjct: 135 LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAM 194
Query: 154 SRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEV 213
+ F GF IGF R W+++LV L+I P + L+ G +A + K +AY +AG +AEEV
Sbjct: 195 ATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEV 254
Query: 214 IGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY- 272
+ +RTV AF G+++ + Y L + G K + + +G+ +++ S+AL WY
Sbjct: 255 LAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYG 314
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
TS+V+ K + G + T V+I S+GQA+P+I AF A+ AAY IF +I+
Sbjct: 315 TSLVISKEYSIG-QVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSID 373
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
SK G K + G+++F ++ FSYPSR DV I LNL + +G+ VALVG SG GKST
Sbjct: 374 SFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTT 433
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDAT 452
V L++R Y+P G + +D DIR +++++LR+ IG+V+QEP LFAT+I ENI YG+++ T
Sbjct: 434 VQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVT 493
Query: 453 LEELKRAVK 461
++E+++AVK
Sbjct: 494 MDEIEKAVK 502
Score = 194 bits (493), Expect = 4e-49
Identities = 106/311 (34%), Positives = 174/311 (55%), Gaps = 2/311 (0%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I+ G I + WQ++L+ L+IVP IA+AG + G K +K +G+IA E
Sbjct: 837 IANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATE 896
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N RTV + E++ Y +L Y N K G+ +++ S+A +
Sbjct: 897 AIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRF 956
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
+ +V + + +V +++GQ + + +AK +A I +IE+
Sbjct: 957 GAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSID 1016
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
S G K + L+G+++FN+V F+YP+RPD+ + LNL++ G+ +ALVG SG GKSTV
Sbjct: 1017 SYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTV 1076
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDAT 452
V L+ERFY+P++G + LD ++ +L+++WLR +G+V+QEP LF SI ENI YG +
Sbjct: 1077 VQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1136
Query: 453 L--EELKRAVK 461
+ +E++RA K
Sbjct: 1137 VSQDEIERAAK 1147
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein
1) (CD243 antigen)
Length = 1280
Score = 268 bits (686), Expect = 2e-71
Identities = 157/482 (32%), Positives = 262/482 (53%), Gaps = 25/482 (5%)
Query: 5 EGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINVIGLAY 64
E D+++K+ VS+ +F +++ D + M +G++ AI+HGA +P+ + FG++ ++ A
Sbjct: 24 EKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAG 83
Query: 65 LFPKEASHKVAKSKCSNIIFILDRGGLLDAYWRKTSSKDENGLFKVYV------------ 112
S+ +S ++ F ++ + Y S L Y+
Sbjct: 84 NLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQ 143
Query: 113 --KSRYKFI*Y*GIHWRGHFCYYK*HYYCSRCS-----IREG------NFLHYISRFIAG 159
K R +F G F + +R + I EG F ++ F G
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 160 FTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVRT 219
F +GF R W+++LV L+I P + L+ +A + K AY +AG +AEEV+ +RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 220 VQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVHK 279
V AF G+++ + Y L + G K + + +G+ +++ S+AL WY + +V
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 280 NIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTGR 339
+ G+ T +V+I S+GQA+P I AF A+ AAY IF++I+ SK+G
Sbjct: 324 GEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 383
Query: 340 KLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIERF 399
K + G+++F +V FSYPSR +V I LNL + +G+ VALVG SG GKST V L++R
Sbjct: 384 KPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 443
Query: 400 YEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATLEELKRA 459
Y+P G + +D DIR +++++LR+ IG+V+QEP LFAT+I ENI YG+++ T++E+++A
Sbjct: 444 YDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 503
Query: 460 VK 461
VK
Sbjct: 504 VK 505
Score = 193 bits (491), Expect = 7e-49
Identities = 108/311 (34%), Positives = 175/311 (55%), Gaps = 2/311 (0%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I+ G I F+ WQ++L+ L+IVP IA+AG + G K +K AG+IA E
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATE 899
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N RTV + E++ Y +L Y N + G+ +++ S+A +
Sbjct: 900 AIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRF 959
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
+ +V + + + VV +++GQ + + +AK +A I +IE+ +
Sbjct: 960 GAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLID 1019
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
S G + L+G++ F +V F+YP+RPD+ + L+L++ G+ +ALVG SG GKSTV
Sbjct: 1020 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDAT 452
V L+ERFY+P++G++LLD +I+ L+++WLR +G+V+QEP LF SI ENI YG +
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 453 L--EELKRAVK 461
+ EE+ RA K
Sbjct: 1140 VSQEEIVRAAK 1150
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1279
Score = 265 bits (676), Expect = 2e-70
Identities = 170/486 (34%), Positives = 258/486 (52%), Gaps = 40/486 (8%)
Query: 8 ERKKEHKVSM---LKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFG----KLINVI 60
+RKK V M L LF ++D D + M +G+I AI HG+ +P+ I FG K ++
Sbjct: 30 KRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTA 89
Query: 61 GLAYLFPKEAS------HKVAKSKCSNIIFI---LDRGGLLDAY-----WRKTSSKDENG 106
G + FP S K+ + + + + L G L+ AY W + +
Sbjct: 90 G-NFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIR- 147
Query: 107 LFKVYVKSRYKFI*Y*GIHWRGHFCYYK*HYYCSRCS-----IREG------NFLHYISR 155
K R KF G F +R + I EG F ++
Sbjct: 148 ------KIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVAT 201
Query: 156 FIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIG 215
F AGF +GF+R W+++LV ++I P + L+ +A + K AY +AG +AEE +G
Sbjct: 202 FFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALG 261
Query: 216 NVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSV 275
+RTV AF G+ + + Y+ L G K ++ + +G +++ S+AL WY S
Sbjct: 262 AIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGST 321
Query: 276 VVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSS 335
+V G + T +++I S+GQAAP I AF A+ AAY IF++I+ + S
Sbjct: 322 LVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFS 381
Query: 336 KTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSL 395
+ G K + G+++FNDV FSYPSR +V I LNL + +G+ VALVG SG GKST V L
Sbjct: 382 ERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL 441
Query: 396 IERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATLEE 455
I+R Y+P G I +D DIR ++ +LR+ IG+V+QEP LF+T+I ENI YG+ + T++E
Sbjct: 442 IQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDE 501
Query: 456 LKRAVK 461
+K+AVK
Sbjct: 502 IKKAVK 507
Score = 185 bits (469), Expect = 2e-46
Identities = 101/303 (33%), Positives = 167/303 (54%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I+ G I F+ WQ++L+ L++VP IA++G + G + +K AG+IA E
Sbjct: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N+RTV + E + Y L Y N + G+ ++ S+A +
Sbjct: 899 AIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRF 958
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
+ ++ + +V ++LG A+ + +AK +A +F + ER +
Sbjct: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLID 1018
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
S+ G K K +G+I FN+V F+YP+R +V + L+L++ G+ +ALVG SG GKSTV
Sbjct: 1019 SYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1078
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDAT 452
V L+ERFY+P++G +LLD + ++L+++WLR Q+G+V+QEP LF SI ENI YG +
Sbjct: 1079 VQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRV 1138
Query: 453 LEE 455
+ +
Sbjct: 1139 VSQ 1141
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein
3) (MDR1A)
Length = 1276
Score = 256 bits (655), Expect = 7e-68
Identities = 128/316 (40%), Positives = 202/316 (63%), Gaps = 2/316 (0%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F ++ F GF IGF R W+++LV L+I P + L+ G +A + K AY +A
Sbjct: 187 GMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKA 246
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEEV+ +RTV AF G+++ + Y L + G K + + +G+ +++ S+
Sbjct: 247 GAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASY 306
Query: 267 ALLVWY-TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMI 325
AL WY TS+V+ K + G + T +V+I S+GQA+P+I AF A+ AAY +F++I
Sbjct: 307 ALAFWYGTSLVISKEYSIG-QVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKII 365
Query: 326 ERDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGS 385
+ SK+G K + G+++F ++ FSYPSR +V I LNL + +G+ VALVG S
Sbjct: 366 DNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNS 425
Query: 386 GSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENIL 445
G GKST V L++R Y+P+ G + +D DIR +++++LR+ IG+V+QEP LFAT+I ENI
Sbjct: 426 GCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIR 485
Query: 446 YGKDDATLEELKRAVK 461
YG++D T++E+++AVK
Sbjct: 486 YGREDVTMDEIEKAVK 501
Score = 188 bits (477), Expect = 3e-47
Identities = 105/311 (33%), Positives = 171/311 (54%), Gaps = 2/311 (0%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I+ G I + WQ++L+ L+IVP IA+AG + G K +K +G+IA E
Sbjct: 836 IANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATE 895
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N RTV + E++ Y +L Y N K G+ +++ S+A +
Sbjct: 896 AIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRF 955
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
+ +V + + +V +++GQ + + +A +A I +IE+
Sbjct: 956 GAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEID 1015
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
S G K + L+G++QF+ F+YP+RP + + L+L++ G+ +ALVG SG GKSTV
Sbjct: 1016 SYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1075
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDD-- 450
V L+ERFY+P++G + LD +I++L+++WLR Q+G+V+QEP LF SI ENI YG +
Sbjct: 1076 VQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRV 1135
Query: 451 ATLEELKRAVK 461
+ EE+ RA K
Sbjct: 1136 VSYEEIVRAAK 1146
Score = 46.2 bits (108), Expect = 2e-04
Identities = 22/59 (37%), Positives = 36/59 (60%), Gaps = 5/59 (8%)
Query: 3 SKEGDERKKEHK-----VSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
SK G + KKE K VS+L +F +A D + M +G++ AI+HG ++P+ + FG +
Sbjct: 16 SKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDM 74
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 253 bits (647), Expect = 6e-67
Identities = 135/319 (42%), Positives = 204/319 (63%), Gaps = 11/319 (3%)
Query: 149 FLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGL-IAKVR----KAY 203
F+ ++ I GF +GF R W+++LV +S+ P I + TIGL ++K KAY
Sbjct: 220 FIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAA-----TIGLSVSKFTDYELKAY 274
Query: 204 VRAGEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLF 263
+AG +A+EVI ++RTV AF GE+R V Y+ L+ G + G+ G G + C++F
Sbjct: 275 AKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIF 334
Query: 264 LSWALLVWYTS-VVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIF 322
L +A+ WY S +V+ + G L+V++ L+LG A+P + AF +AAA IF
Sbjct: 335 LCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 323 EMIERDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALV 382
E I+R + S+ G KL ++ G I+F++V F YPSRP+V I +LN+ I G++ ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 383 GGSGSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKE 442
G SG+GKST + LI+RFY+P G + +D +DIR L+++WLR QIG+V QEP LF+T+I E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 443 NILYGKDDATLEELKRAVK 461
NI YG++DAT+E++ +A K
Sbjct: 515 NIRYGREDATMEDIVQAAK 533
Score = 172 bits (437), Expect = 1e-42
Identities = 92/301 (30%), Positives = 157/301 (51%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G ++ + I F W++SLV L P +AL+G + G ++ ++A
Sbjct: 877 GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMV 936
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G+I E + N+RTV E R + + + L K + + G C++F++
Sbjct: 937 GQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIAN 996
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
+ Y ++ + F + VV+S +LG+A ++ +AK +A F++++
Sbjct: 997 SASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
R + G K G I F D F+YPSRPD + L++ I G+ +A VG SG
Sbjct: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSG 1116
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST + L+ERFY+P G++++D +D +++++++LR IG+V+QEP LFA SI +NI Y
Sbjct: 1117 CGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKY 1176
Query: 447 G 447
G
Sbjct: 1177 G 1177
Score = 42.4 bits (98), Expect = 0.003
Identities = 22/59 (37%), Positives = 36/59 (60%), Gaps = 1/59 (1%)
Query: 2 ESKEGDERKKEH-KVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINV 59
+S+ DE+K + +V +LF F+ S D LMF+GS+ A +HG + P + FG + +V
Sbjct: 31 KSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDV 89
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 250 bits (639), Expect = 5e-66
Identities = 124/315 (39%), Positives = 199/315 (62%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F I+ F AGF IGF+ W+++LV L++ P I L+ +A V K +AY +A
Sbjct: 190 GMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKA 249
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEEV+ +RTV AF G+++ + Y L + G K + + +G + +++ S+
Sbjct: 250 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASY 309
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY + +V N + G+ T ++++ S+G AP+I AF A+ AAY IF++I+
Sbjct: 310 ALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIID 369
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S G K + G+++F +V F+YPSR +V I LNL + +G+ VALVG SG
Sbjct: 370 NEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSG 429
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R Y+PI G++ +D DIR +++++LR+ IG+V+QEP LFAT+I ENI Y
Sbjct: 430 CGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRY 489
Query: 447 GKDDATLEELKRAVK 461
G+++ T++E+++AVK
Sbjct: 490 GRENVTMDEIEKAVK 504
Score = 164 bits (414), Expect = 6e-40
Identities = 118/456 (25%), Positives = 219/456 (47%), Gaps = 33/456 (7%)
Query: 28 DYVLMFIGSIGAIVHGASVPIFFIFFGKLINVIGLAYLFPKEASHKVAKSKCSNIIFILD 87
++ + +G + A+++G P+F I F K++ V F ++ H+ + C+ +
Sbjct: 705 EWPYLVVGVLCAVINGCIQPVFAIVFSKIVGV------FSRDDDHETKQRNCNLFSLLFL 758
Query: 88 RGGLLD--AYWRKTSSKDENGLFKVYVKSRYKFI*Y*GIHWRGHFCYYK*HYY------- 138
G++ Y+ + + + G + R +++ + + R ++ H
Sbjct: 759 VMGMISFVTYFFQGFTFGKAGEI---LTKRLRYMVFKSM-LRQDISWFDDHKNTTGSLTT 814
Query: 139 -----CSRCSIREGNFLHYISRFIAGFTIGFVRV------WQISLVTLSIVPAIALAGGC 187
S G+ L +++ +A G + WQ++L+ + I+P I L G
Sbjct: 815 RLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGII 874
Query: 188 YAYVTIGLIAKVRKAYVRAGEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKA 247
+ G K +K +G+IA E I N RTV + E++ Y +L Y N K
Sbjct: 875 EMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKK 934
Query: 248 GLAKGLGLGSMHCVLFLSWALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPD 307
G+ +++ S+A + + +V + + VV ++ G +
Sbjct: 935 AHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSF 994
Query: 308 ISAFIRAKAAAYPIFEMIERDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFT 367
+ +AK +A I +IE+ S G K + L+G+++FN V F+YP+RP++ +
Sbjct: 995 APDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQ 1054
Query: 368 NLNLDIPAGKIVALVGGSGSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIG 427
L+ ++ G+ + LVG SG GKSTVV L+ERFY P++G + LD +I++L+++ +R +G
Sbjct: 1055 GLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVR-ALG 1113
Query: 428 LVNQEPALFATSIKENILYGKDDATL--EELKRAVK 461
+V+QEP LF SI ENI YG + + EE+ RA +
Sbjct: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAR 1149
Score = 42.7 bits (99), Expect = 0.002
Identities = 18/54 (33%), Positives = 32/54 (58%)
Query: 1 MESKEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFG 54
M K E++K+ V + +F +AD D + M +G++ AI+HG +P+ + FG
Sbjct: 18 MGKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFG 71
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1281
Score = 250 bits (638), Expect = 6e-66
Identities = 124/315 (39%), Positives = 194/315 (61%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F ++ F AGF +GF+R W+++LV ++I P + L+ +A + K AY +A
Sbjct: 193 GMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKA 252
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEE +G +RTV AF G+ + + Y+ L G K ++ + +G +++ S+
Sbjct: 253 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASY 312
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY S +V G + T +++I S+GQAAP I AF A+ AAY IF++I+
Sbjct: 313 ALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID 372
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S+ G K + G++ F+DV FSYPSR ++ I LNL + +G+ VALVG SG
Sbjct: 373 NNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSG 432
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GK+T + L++R Y+P G I +D DIR ++++LR+ IG+V+QEP LF+T+I ENI Y
Sbjct: 433 CGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRY 492
Query: 447 GKDDATLEELKRAVK 461
G+ + T+EE+K+AVK
Sbjct: 493 GRGNVTMEEIKKAVK 507
Score = 185 bits (469), Expect = 2e-46
Identities = 103/305 (33%), Positives = 169/305 (54%), Gaps = 2/305 (0%)
Query: 159 GFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVR 218
G I F+ WQ++L+ LS+VP IA++G + G + +KA AG+IA E I N+R
Sbjct: 847 GIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIR 906
Query: 219 TVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVH 278
TV + E + Y L + Y N + G+ ++ S+A + + ++
Sbjct: 907 TVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIV 966
Query: 279 KNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTG 338
+ +V ++LG A+ + +AK +A +F + ER + S G
Sbjct: 967 NGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEG 1026
Query: 339 RKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIER 398
K +G + FN+V F+YP+R ++ + L+L++ G+ +ALVG SG GKSTVV L+ER
Sbjct: 1027 LWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1086
Query: 399 FYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATL--EEL 456
FY+P++G +LLD + ++L+++WLR Q+G+V+QEP LF SI ENI YG + + +E+
Sbjct: 1087 FYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEI 1146
Query: 457 KRAVK 461
RA K
Sbjct: 1147 VRAAK 1151
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/50 (36%), Positives = 33/50 (66%)
Query: 7 DERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
+++KK + + L LF ++D D + M +G+I AI HG+ +P+ I FG++
Sbjct: 32 NKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEM 81
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 250 bits (638), Expect = 6e-66
Identities = 124/315 (39%), Positives = 199/315 (62%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F I+ F+AGF IGF+ W+++LV L++ P I L+ +A V K +AY +A
Sbjct: 190 GMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKA 249
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEEV+ +RTV AF G+++ + Y L + G K + + +G + +++ S+
Sbjct: 250 GAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASY 309
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY + +V N + GE T ++++ S+G AP+I AF A+ AA+ IF++I+
Sbjct: 310 ALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIID 369
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S G K + G+++F +V F+YPSR +V I LNL + +G+ VALVG SG
Sbjct: 370 NEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSG 429
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R Y+P+ G + +D DIR +++++LR+ IG+V+QEP LFAT+I ENI Y
Sbjct: 430 CGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRY 489
Query: 447 GKDDATLEELKRAVK 461
G++D T++E+++AVK
Sbjct: 490 GREDVTMDEIEKAVK 504
Score = 183 bits (465), Expect = 7e-46
Identities = 126/450 (28%), Positives = 220/450 (48%), Gaps = 22/450 (4%)
Query: 28 DYVLMFIGSIGAIVHGASVPIFFIFFGKLINVIGLAYLFPKEASHKVAKSKCSNIIFILD 87
++ + +G + A+++G P+F I F +++ V F ++ H+ + C+
Sbjct: 705 EWPYLLVGVLCAVINGCIQPVFAIVFSRIVGV------FSRDDDHETKRQNCNLFSLFFL 758
Query: 88 RGGLLD--AYWRK--TSSKDENGLFKVYVKSRYKFI*Y*GIHW----RGHFCYYK*HYYC 139
GL+ Y+ + T K L K +K + I W +
Sbjct: 759 VMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLAS 818
Query: 140 SRCSIRE--GNFLHYISRFIA----GFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTI 193
S++ G L +++ +A G + V WQ++L+ + I+P I L G +
Sbjct: 819 DASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLS 878
Query: 194 GLIAKVRKAYVRAGEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGL 253
G K +K +G+IA E I N RT+ + E++ Y +L Y N K G+
Sbjct: 879 GQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGI 938
Query: 254 GLGSMHCVLFLSWALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIR 313
+++ S+A + + +V + + VV ++ G + + +
Sbjct: 939 TFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAK 998
Query: 314 AKAAAYPIFEMIERDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDI 373
AK +A I +IE+ S G K + L+G+++FN V F+YP+RP++ + L+L++
Sbjct: 999 AKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEV 1058
Query: 374 PAGKIVALVGGSGSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEP 433
G+ +ALVG SG GKSTVV L+ERFY+P++G + LD +I++L+++WLR +G+V+QEP
Sbjct: 1059 KKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEP 1118
Query: 434 ALFATSIKENILYGKDDATL--EELKRAVK 461
LF SI ENI YG + + EE+ RA K
Sbjct: 1119 ILFDCSIAENIAYGDNSRAVSHEEIVRAAK 1148
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 5/59 (8%)
Query: 3 SKEGDERKKEHK-----VSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
SK G + KKE K V + +F +AD D + M +G++ AI+HG +P+ + FG +
Sbjct: 16 SKMGKKSKKEKKEKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNM 74
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 247 bits (631), Expect = 4e-65
Identities = 125/315 (39%), Positives = 194/315 (60%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F I+ F AGF +GF+R W+++LV ++I P + L+ +A + K AY +A
Sbjct: 190 GMFFQAIATFFAGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKA 249
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEE G +RTV AF G+ + + Y+ L G K ++ + +G +++ S+
Sbjct: 250 GAVAEEAPGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASY 309
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY S +V G + T +++I S+GQAAP I AF A+ AAY IF++I+
Sbjct: 310 ALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID 369
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S+ G K + G+++F+DV FSYPSR ++ I LNL + +G+ VALVG SG
Sbjct: 370 NNPKIDSFSERGHKPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSG 429
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R Y+P G+I +D DIR +++ LR+ IG+V+QEP LF+T+I ENI Y
Sbjct: 430 CGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRY 489
Query: 447 GKDDATLEELKRAVK 461
G+ + T++E+++AVK
Sbjct: 490 GRGNVTMDEIEKAVK 504
Score = 186 bits (471), Expect = 1e-46
Identities = 105/305 (34%), Positives = 168/305 (54%), Gaps = 2/305 (0%)
Query: 159 GFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVR 218
G I F+ WQ++L+ LS+VP IA+AG + G + +K AG+IA E I N+R
Sbjct: 842 GIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIR 901
Query: 219 TVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVH 278
TV + E + Y L Y N + G+ ++ S+A + S ++
Sbjct: 902 TVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIV 961
Query: 279 KNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTG 338
+ +V+ ++LG A+ + +AK +A +F + ER + S G
Sbjct: 962 NGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEG 1021
Query: 339 RKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIER 398
K +G + FN+V F+YP+R +V + L+L++ G+ +ALVG SG GKSTVV L+ER
Sbjct: 1022 LWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1081
Query: 399 FYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATL--EEL 456
FY+P++G +LLD + ++L+++WLR Q+G+V+QEP LF SI ENI YG + + +E+
Sbjct: 1082 FYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEI 1141
Query: 457 KRAVK 461
RA K
Sbjct: 1142 VRAAK 1146
Score = 48.1 bits (113), Expect = 5e-05
Identities = 21/55 (38%), Positives = 38/55 (68%), Gaps = 1/55 (1%)
Query: 3 SKEGDERKKE-HKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
S +G E+KK+ + + +L LF ++D D + MF+G++ AI HG+ +P+ I FG++
Sbjct: 24 SNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEM 78
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 247 bits (630), Expect = 5e-65
Identities = 125/315 (39%), Positives = 193/315 (60%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F I+ F AGF +GF+R W+++LV ++I + L+ +A + K AY +A
Sbjct: 190 GMFFQAIATFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKA 249
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEE +G +RTV AF G+ + + Y+ L G K ++ + +G +++ S+
Sbjct: 250 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASY 309
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY S +V G + T +++I S+GQAAP I AF A+ AAY IF++I+
Sbjct: 310 ALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIID 369
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S+ G K + G+++F+DV FSYPSR ++ I LNL + +G+ VALVG SG
Sbjct: 370 NNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSG 429
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R Y+P G I +D DIR +++ LR+ IG+V+QEP LF+T+I ENI Y
Sbjct: 430 CGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRY 489
Query: 447 GKDDATLEELKRAVK 461
G+ + T++E+K+AVK
Sbjct: 490 GRGNVTMDEIKKAVK 504
Score = 186 bits (471), Expect = 1e-46
Identities = 104/305 (34%), Positives = 169/305 (55%), Gaps = 2/305 (0%)
Query: 159 GFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVR 218
G I F+ WQ++L+ LS+VP IA+AG + G + +K AG+IA E I N+R
Sbjct: 844 GIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIR 903
Query: 219 TVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVH 278
TV + E + Y L Y N + G+ ++ S+A + S ++
Sbjct: 904 TVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIV 963
Query: 279 KNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTG 338
+ +V+ ++LG A+ + +AK +A +F + ER + S+ G
Sbjct: 964 NGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREG 1023
Query: 339 RKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIER 398
K +G + FN+V F+YP+R +V + L+L++ G+ +ALVG SG GKSTVV L+ER
Sbjct: 1024 MWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1083
Query: 399 FYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATL--EEL 456
FY+P++G +LLD + ++L+++WLR Q+G+V+QEP LF SI +NI YG + + +E+
Sbjct: 1084 FYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEI 1143
Query: 457 KRAVK 461
RA K
Sbjct: 1144 VRAAK 1148
Score = 42.4 bits (98), Expect = 0.003
Identities = 17/56 (30%), Positives = 35/56 (62%)
Query: 1 MESKEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
+ ++ +++KK + + L LF ++D D + M +G+ AI HG+ +P+ I FG++
Sbjct: 23 ISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEM 78
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 241 bits (615), Expect = 3e-63
Identities = 120/315 (38%), Positives = 193/315 (61%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F I+ F+A F +GF+ W+++LV L++ P I L+ +A V K +AY +A
Sbjct: 190 GMFFQSIATFLAAFIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKA 249
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G +AEEV+ +RTV AF G+ + + Y L + G K + + +G + +++ S+
Sbjct: 250 GAVAEEVLAAIRTVIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASY 309
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY + +V N + G+ T +++ S+G AP+I F A+ AAY IF++I+
Sbjct: 310 ALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIID 369
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
+ S G K + G+++F +V FSYPSR + I LNL + +G+ VALVG SG
Sbjct: 370 NEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSG 429
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R Y+P G + +D DIR +++++LR+ IG+V+QEP LFAT+I ENI Y
Sbjct: 430 CGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRY 489
Query: 447 GKDDATLEELKRAVK 461
G+++ T++E+++AVK
Sbjct: 490 GRENVTMDEIEKAVK 504
Score = 186 bits (473), Expect = 8e-47
Identities = 107/321 (33%), Positives = 172/321 (53%), Gaps = 2/321 (0%)
Query: 143 SIREGNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKA 202
S R ++ G I V WQ++L+ + I P I L+G V G K +K
Sbjct: 828 SSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKE 887
Query: 203 YVRAGEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVL 262
+G+IA E I N RTV + E++ Y +L Y N K G+ ++
Sbjct: 888 LEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMM 947
Query: 263 FLSWALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIF 322
+ S+A + + +V I VV ++ G A+ + +AK +A I
Sbjct: 948 YFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHII 1007
Query: 323 EMIERDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALV 382
++E+ S G K + L+G+++FN+V F+YP+RPD+ + L+L++ G+ +ALV
Sbjct: 1008 RIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1067
Query: 383 GGSGSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKE 442
G SG GKSTVV L+ERFY+P++G + LD +I++L+++WLR +G+V+QEP LF SI E
Sbjct: 1068 GSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAE 1127
Query: 443 NILYGKDDATL--EELKRAVK 461
NI YG + + +E++RA K
Sbjct: 1128 NIAYGDNSRVVSQDEIERAAK 1148
Score = 43.9 bits (102), Expect = 9e-04
Identities = 17/55 (30%), Positives = 34/55 (60%)
Query: 2 ESKEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
+SK+ + K+ V + +F +AD D + M +G++ A++HG S+P+ + FG +
Sbjct: 21 KSKKEKKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNM 75
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 240 bits (613), Expect = 5e-63
Identities = 128/314 (40%), Positives = 190/314 (59%), Gaps = 1/314 (0%)
Query: 149 FLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGE 208
F+ ++ I GF +GF + W+++LV +S+ P I L KAY +AG
Sbjct: 220 FIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELKAYAKAGS 279
Query: 209 IAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWAL 268
+A+EVI ++RTV AF GE++ V Y+ L+ G + G+ G G M C++F +AL
Sbjct: 280 VADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCLIFFCYAL 339
Query: 269 LVWYTS-VVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIER 327
WY S +V+ + + G L+V+I L+LG A+P + AF +AAA IFE I+R
Sbjct: 340 AFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASSIFETIDR 399
Query: 328 DTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGS 387
+ S+ G KL ++ G I+F++V F YPSRP+V I NL++ I G++ ALVG SG+
Sbjct: 400 KPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTALVGPSGA 459
Query: 388 GKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYG 447
GKST + LI RFY P G + ++ +DIR ++WLR QIG+V QEP LF +I E I YG
Sbjct: 460 GKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTIAEKIRYG 519
Query: 448 KDDATLEELKRAVK 461
++DAT+E+L +A K
Sbjct: 520 REDATMEDLIQAAK 533
Score = 183 bits (464), Expect = 9e-46
Identities = 98/317 (30%), Positives = 171/317 (53%), Gaps = 2/317 (0%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G ++ + I F+ W+++L + P +AL+G + G ++ ++A +A
Sbjct: 877 GMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKA 936
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G+I E + N+RTV E + + +++A L K Y K GL G C+ F++
Sbjct: 937 GQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIAN 996
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
+ Y ++ + F + VV+S +LG+A+ ++ +AK +A F++++
Sbjct: 997 SASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLD 1056
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
R S G K G I F D F+YPSRPD+ + L++ + + +A VG SG
Sbjct: 1057 RQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSG 1116
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST + L+ERFY+P G++++D +D R++++++LR IG+V+QEP LFA SIK+NI Y
Sbjct: 1117 CGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKY 1176
Query: 447 GKD--DATLEELKRAVK 461
G + + +E + A K
Sbjct: 1177 GDNTQEIPMERIIAAAK 1193
Score = 35.4 bits (80), Expect = 0.31
Identities = 18/59 (30%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 2 ESKEGDERKKEH-KVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINV 59
+S+ D++K + ++ +LF F+ D LM +GS+ A +HG + P + FG + +V
Sbjct: 31 KSRLQDKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGIAQPGVLLIFGTMTDV 89
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 238 bits (608), Expect = 2e-62
Identities = 126/315 (40%), Positives = 189/315 (60%), Gaps = 1/315 (0%)
Query: 148 NFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAG 207
+FL +S + G +GF R W+++LV L++ P I + KAY +AG
Sbjct: 219 HFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAG 278
Query: 208 EIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWA 267
IA+EV+ ++RTV AF GE + V Y+ L+ G G+ G G M C++F +A
Sbjct: 279 SIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYA 338
Query: 268 LLVWYTS-VVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
L WY S +V+ + G L V+++ +++G A+ + F +AA IF+ I+
Sbjct: 339 LAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTID 398
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
R V S G KL ++ G I+F++V F YPSRPDV I NL++ I G+ ALVG SG
Sbjct: 399 RQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSG 458
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
+GKST + LI+RFY+P G + LD +DIR L+++WLR QIG+V QEP LF+T+I ENI +
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRF 518
Query: 447 GKDDATLEELKRAVK 461
G++DAT+E++ +A K
Sbjct: 519 GREDATMEDIVQAAK 533
Score = 177 bits (450), Expect = 4e-44
Identities = 121/469 (25%), Positives = 221/469 (46%), Gaps = 14/469 (2%)
Query: 2 ESKEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINVIG 61
+SK+ D +E + + ++ + ++ + +GS+ A ++GA PI+ + F +L+ G
Sbjct: 725 DSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLL---G 781
Query: 62 LAYLFPKEASHKVAKSKCSNIIFILDRGGLLDAYWRKTSSKDENGLFKVYVKSRYKFI*Y 121
L KE S C + + T +K L K K +K +
Sbjct: 782 TFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLG 841
Query: 122 *GIHW----RGHFCYYK*HYYCSRCSIRE------GNFLHYISRFIAGFTIGFVRVWQIS 171
I W R + ++ G ++ + IA I F W++S
Sbjct: 842 QDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLS 901
Query: 172 LVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVRTVQAFAGEERAVR 231
L+ P +AL+G + G ++ ++A +AG+I E + N+RTV E R ++
Sbjct: 902 LIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIK 961
Query: 232 SYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVHKNIANGGESFTTM 291
+++ L +Y + GL + FL+ + Y ++ F +
Sbjct: 962 AFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVV 1021
Query: 292 LNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTGRKLSKLDGHIQFN 351
+V +S ++G+ ++ +AK +A F++++R S+ G K G I F
Sbjct: 1022 SSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFI 1081
Query: 352 DVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIERFYEPISGQILLDK 411
D F+YPSRPD+ + L++ + G+ +A VG SG GKST + L+ERFY+P G +++D
Sbjct: 1082 DCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDG 1141
Query: 412 NDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATLEELKRAV 460
+D +++++++LR IG+V+QEP LF SI +NI YG D+ ++RA+
Sbjct: 1142 HDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYG-DNTKEISVERAI 1189
Score = 38.9 bits (89), Expect = 0.028
Identities = 21/56 (37%), Positives = 31/56 (54%), Gaps = 5/56 (8%)
Query: 4 KEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINV 59
KEGD R V +LF F+ S D LM +G + A++HG + P I FG + ++
Sbjct: 39 KEGDIR-----VGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDI 89
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 237 bits (605), Expect = 4e-62
Identities = 125/314 (39%), Positives = 187/314 (58%), Gaps = 1/314 (0%)
Query: 149 FLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGE 208
FL +S ++G +GF R W+++LV L++ P I + KAY +AG
Sbjct: 220 FLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGS 279
Query: 209 IAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWAL 268
IA+EV+ ++RTV AF GE + V Y+ LM G G+ G G M C++F +AL
Sbjct: 280 IADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYAL 339
Query: 269 LVWYTS-VVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIER 327
WY S +V+ + G L V+I+ +++G A+ + F +AA IF+ I+R
Sbjct: 340 AFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDR 399
Query: 328 DTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGS 387
V S G KL ++ G I+F++V F YPSRP+V I NL++ I G+ A VG SG+
Sbjct: 400 QPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGA 459
Query: 388 GKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYG 447
GKST + LI+RFY+P G + LD +DIR L+++WLR QIG+V QEP LF+T+I ENI G
Sbjct: 460 GKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLG 519
Query: 448 KDDATLEELKRAVK 461
+++AT+E++ +A K
Sbjct: 520 REEATMEDIVQAAK 533
Score = 168 bits (425), Expect = 3e-41
Identities = 92/314 (29%), Positives = 165/314 (52%), Gaps = 1/314 (0%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G ++ + I F+ W++SLV P +AL+G + G ++ ++ +A
Sbjct: 877 GMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKA 936
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
G+I E + N+RTV E R +++++ L K+Y + GL + FL+
Sbjct: 937 GQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLAN 996
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
+ Y ++ N F + ++ +S ++G+ ++ +AK +A F++++
Sbjct: 997 SAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLD 1056
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
R S G K G I F D F+YPSRPD+ + L++ + G+ +A VG SG
Sbjct: 1057 RKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSG 1116
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST + L+ERFY+P G +++D +D +++++++LR IG+V+QEP LF SI +NI Y
Sbjct: 1117 CGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKY 1176
Query: 447 GKDDATLEELKRAV 460
G D+ ++RA+
Sbjct: 1177 G-DNTKEISVERAI 1189
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/59 (38%), Positives = 37/59 (61%), Gaps = 1/59 (1%)
Query: 2 ESKEGDERKKEH-KVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINV 59
+S+ D++K E +V +LF F+ S D LMF+GS+ A++HG + P I FG L ++
Sbjct: 31 KSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDI 89
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein
A)
Length = 1321
Score = 235 bits (600), Expect = 2e-61
Identities = 154/476 (32%), Positives = 249/476 (51%), Gaps = 31/476 (6%)
Query: 13 HKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL----------INVIGL 62
+KVS+ +L+ + + + +L+FIG++ A++ GA +P+ I GK+ IN G
Sbjct: 58 NKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGS 117
Query: 63 AYLFPKEASHK---------VAKSKCSNIIFILDRGGLLDAYWRKTSSKDENGLFKVYVK 113
+L + K V S + + + G + + + + N L + +VK
Sbjct: 118 TFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVK 177
Query: 114 SRYKFI*Y*GIHW--RGHFCYYK*HYYCSRCSIREGN------FLHYISRFIAGFTIGFV 165
S + I W H + + ++EG Y+S+FI GF + F
Sbjct: 178 SILRQ----EISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFT 233
Query: 166 RVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVRTVQAFAG 225
WQ++LV L++ P AL G A + Y +AG++ EE I ++RTV + G
Sbjct: 234 HSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNG 293
Query: 226 EERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVHKNIANGG 285
+ Y A+ + G GL G+ G+M F+S+AL + VH N G
Sbjct: 294 LRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFG 353
Query: 286 ESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSKTGRKLSKLD 345
+ TT +V++ ++LG A P ++ A+ AA I+E+++R V SSK GRK K+
Sbjct: 354 DMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIK 413
Query: 346 GHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIERFYEPISG 405
G I +V F+YPSRPDV I +NL + AG+ VALVG SG GKST++SL+ R+Y+ + G
Sbjct: 414 GDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKG 473
Query: 406 QILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATLEELKRAVK 461
+I +D D+R+++L++LR+ + +V+QEPALF +I+ENI GK+ T EE+ A K
Sbjct: 474 KITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACK 529
Score = 157 bits (398), Expect = 4e-38
Identities = 102/309 (33%), Positives = 159/309 (51%), Gaps = 5/309 (1%)
Query: 157 IAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGN 216
+AG + F WQ++L+ ++I+P +A G K + +G+IA E I N
Sbjct: 885 VAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIEN 944
Query: 217 VRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFL--SWALLVWYTS 274
VRTVQA A E+ ++ L + K +GL G VL+L + A +
Sbjct: 945 VRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLAL 1004
Query: 275 VVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKS 334
++ M + IS +LG A + +A A IF M+ + +
Sbjct: 1005 IITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSL 1064
Query: 335 SKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVS 394
S G K KL G + F +V F+YP RP++ I L+ + G+ +ALVG SG GKSTVV+
Sbjct: 1065 SLAGEK-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVA 1123
Query: 395 LIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKD--DAT 452
L+ERFY+ + G+I +D ++I+ L+ + R QI +V+QEP LF SI ENI+YG D T
Sbjct: 1124 LLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVT 1183
Query: 453 LEELKRAVK 461
+ +++ A +
Sbjct: 1184 MAQVEEAAR 1192
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 212 bits (539), Expect = 2e-54
Identities = 116/315 (36%), Positives = 173/315 (54%), Gaps = 6/315 (1%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I F+ G FV W+++LV LS VP I A A + L K K+Y A + EE
Sbjct: 201 IMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
V +RTV AF+G+E+ + L+ GRK GL G+G +++L AL +WY
Sbjct: 261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWY 320
Query: 273 TSVVVHKNIANGGESFT------TMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
++ +T + V++ +LG A+P + A A AA +F +I+
Sbjct: 321 GVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIID 380
Query: 327 RDTVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSG 386
R + + G + GHI+F + F YP+RPDV I L +D+ G+ VA VG SG
Sbjct: 381 RPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASG 440
Query: 387 SGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST++ L++RFY+P +G + LD D+R L++ WLR QIG+V QEP LFAT+I ENI Y
Sbjct: 441 CGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRY 500
Query: 447 GKDDATLEELKRAVK 461
G+ AT ++++A +
Sbjct: 501 GRPSATQADIEKAAR 515
Score = 160 bits (404), Expect = 8e-39
Identities = 130/487 (26%), Positives = 216/487 (43%), Gaps = 48/487 (9%)
Query: 4 KEGDERKKEHKVSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKLINVIGLA 63
K+ +++ KVS +L +S ++ + +G I +++HGA+ P++ +FFG ++
Sbjct: 708 KKKKDKEVVSKVSFTQLMKL-NSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILS-- 764
Query: 64 YLFPKEASHKVAKSKCSNIIFIL-------DRGGLLDAYWRKTSSKDENGLFKVYVKSRY 116
+ V +++ I I G +L Y T+ K+ + R
Sbjct: 765 -----DGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAG------VKMTTRLRK 813
Query: 117 KFI*Y*GIHWRGHFCYYK*HY-----YCSR----CS-------IREGNFLHYISRFIAGF 160
+ G Y+ CSR CS R G L ++ + G
Sbjct: 814 RAF---GTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGM 870
Query: 161 TIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGNVRTV 220
+GFV WQ +L+TL +P + L+ + K + + A ++A E I N+RTV
Sbjct: 871 VVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTV 930
Query: 221 QAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVVVHKN 280
E + + Y + + V R+ +GL FL++ + ++Y ++V +
Sbjct: 931 NGLCLERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEE 990
Query: 281 IANGGESFTTMLNVVISGLSLGQA---APDISAFIRAKAAAYPIFEMIERDTVSKKSSKT 337
N + ++ LGQA AP+++ I + +F+ T
Sbjct: 991 RMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFK--RTSTQPNPPQSP 1048
Query: 338 GRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLIE 397
+ K +G I + +V F YP+R I LNL I VALVG SGSGKST V L+
Sbjct: 1049 YNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLL 1108
Query: 398 RFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYG---KDDATLE 454
R+Y+P+SG + L E L LR ++GLV+QEP LF +I ENI YG +DD +++
Sbjct: 1109 RYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQ 1168
Query: 455 ELKRAVK 461
E+ A K
Sbjct: 1169 EIIEAAK 1175
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 196 bits (498), Expect = 1e-49
Identities = 112/324 (34%), Positives = 184/324 (56%), Gaps = 7/324 (2%)
Query: 143 SIREGNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKA 202
S + G+F++ + FI I F W+++L S +P + L A L A+ +++
Sbjct: 193 SEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQES 252
Query: 203 YVRAGEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVL 262
Y AG +AEE++ ++RTV +F GE+ V+ Y+ L+ + G GL + +L
Sbjct: 253 YAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSML 312
Query: 263 FLSWALLVWY--TSVVVHKNIANGGESFTTML----NVVISGLSLGQAAPDISAFIRAKA 316
+LS A WY ++ +N+ N + ++ +++ ++ + AP + +F A+
Sbjct: 313 YLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARG 372
Query: 317 AAYPIFEMIERDTVSKKSSKTGRKLSK-LDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPA 375
A +F++I+ + S G+ L+ L G ++F DV F YPSRP+V + LN+ I A
Sbjct: 373 CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRA 432
Query: 376 GKIVALVGGSGSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPAL 435
G+ VALVG SG GKST V L++RFY+P+ G +LLD DIR+ +++WLR I +V QEP L
Sbjct: 433 GQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVL 492
Query: 436 FATSIKENILYGKDDATLEELKRA 459
F +I +NI YGK AT +E++ A
Sbjct: 493 FLGTIAQNISYGKPGATQKEIEAA 516
Score = 139 bits (350), Expect = 2e-32
Identities = 89/301 (29%), Positives = 156/301 (51%), Gaps = 7/301 (2%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
+S FI+ ++ W+++L+ L+ P I + A + + + ++ A IA E
Sbjct: 860 LSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATE 919
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N+RTV E +R Y + + V R+ +G+ +M F ++A+ + Y
Sbjct: 920 SITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCY 979
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
V+V + + ++ + L Q+ AF A A + +F++++R +
Sbjct: 980 GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQ 1039
Query: 333 KSSKT-----GRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGS 387
T ++L+ +G +++ + F YP+RPD I L+L++ G+ VALVG SG
Sbjct: 1040 SPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGC 1098
Query: 388 GKSTVVSLIERFYEPISGQILLDKNDIR-ELDLKWLRQQIGLVNQEPALFATSIKENILY 446
GKST V L++R+Y+P G I +D +DI+ +L L +R ++G+V+QEP LF SI ENI Y
Sbjct: 1099 GKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAY 1158
Query: 447 G 447
G
Sbjct: 1159 G 1159
>PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1
Length = 1362
Score = 192 bits (489), Expect = 1e-48
Identities = 113/317 (35%), Positives = 171/317 (53%), Gaps = 13/317 (4%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYV----RAGE 208
I+ F++GF I F+R W+ +L+ S+ PAI G + + I K K + +
Sbjct: 225 IATFVSGFVIAFIRHWKFTLILSSMFPAICGGIG----LGVPFITKNTKGQIAVVAESST 280
Query: 209 IAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWAL 268
EEV N+R AF ++ + Y L+ G +A GL +G M V + + L
Sbjct: 281 FVEEVFSNIRNAFAFGTQDILAKLYNKYLITAQRFGINKAIAMGLMVGWMFFVAYGVYGL 340
Query: 269 LVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERD 328
W ++H + + V+I+ SL +P + +F+ +AA IF+ I+R
Sbjct: 341 AFWEGGRLLHAGDLDVSKLIGCFFAVLIASYSLANISPKMQSFVSCASAAKKIFDTIDRV 400
Query: 329 TVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSG 388
+ + TG + + G I+ ++ F YP+RP+V + N +L P+GKI ALVG SGSG
Sbjct: 401 SPINAFTPTGDVVKDIKGEIELKNIRFVYPTRPEVLVLDNFSLVCPSGKITALVGASGSG 460
Query: 389 KSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGK 448
KST++ L+ERFY+PI GQ+ LD D+R L++ LR QI LV QEP LFAT++ ENI YG
Sbjct: 461 KSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQISLVQQEPVLFATTVFENITYGL 520
Query: 449 DDA-----TLEELKRAV 460
D + EEL+R V
Sbjct: 521 PDTIKGTLSKEELERRV 537
Score = 154 bits (389), Expect = 5e-37
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 2/317 (0%)
Query: 147 GNFLHYISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRA 206
G F ++ I+ + W++ LVTLS P I AG + K+ AY +
Sbjct: 917 GTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQVQEKLSAAYKES 976
Query: 207 GEIAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSW 266
A E +RTV + EE Y +L+K A L GL + V FL
Sbjct: 977 AAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLKSGLFFSAAQGVTFLIN 1036
Query: 267 ALLVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIE 326
AL WY S ++ K N + +T + +V GQ + +AKAAA I + E
Sbjct: 1037 ALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAAGEIKYLSE 1096
Query: 327 RDTVSKKSSKTGRKLSKLDGH-IQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGS 385
S G+K+ L I+F V FSYP+R + + LNL + G+ VA VG S
Sbjct: 1097 SKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQFVAFVGSS 1156
Query: 386 GSGKSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENIL 445
G GKST + LIERFY+ +G +L+D ++R+ ++ R+QI LV+QEP L+ +++ENI+
Sbjct: 1157 GCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALVSQEPTLYQGTVRENIV 1216
Query: 446 YG-KDDATLEELKRAVK 461
G D + EE+ A K
Sbjct: 1217 LGASKDVSEEEMIEACK 1233
>MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1280
Score = 186 bits (473), Expect = 8e-47
Identities = 105/305 (34%), Positives = 174/305 (56%), Gaps = 1/305 (0%)
Query: 157 IAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEEVIGN 216
+ G+ GFV W+++L+ + ++P I + + + RK + +AG +A EV+ N
Sbjct: 201 VIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFAKAGSLATEVMEN 260
Query: 217 VRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYTSVV 276
+RTVQAF E+ + + A++ G + LA L + ++++S+ + ++ S +
Sbjct: 261 IRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYVSYTVAFFFGSYL 320
Query: 277 VHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKKSSK 336
V + + +T L V++ LG AP +AF ++AAAY IF+ I+R
Sbjct: 321 VEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKAIDR-VPPVDIDA 379
Query: 337 TGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVVSLI 396
G + I+F +V F+YP+RP + +F +L+L I G+ VA G SG GKS+V+ LI
Sbjct: 380 GGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLI 439
Query: 397 ERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATLEEL 456
+RFY+PI G +L+D +REL L+ R QIG+V+QEP LFA ++ EN+ GK +AT EE+
Sbjct: 440 QRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMENVRMGKPNATDEEV 499
Query: 457 KRAVK 461
A +
Sbjct: 500 VEACR 504
Score = 131 bits (330), Expect = 3e-30
Identities = 86/308 (27%), Positives = 155/308 (49%), Gaps = 11/308 (3%)
Query: 158 AGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGE----IAEEV 213
+G +GF+ W+++LV L+ +P + GC + + + R G+ I E
Sbjct: 849 SGLVVGFIYQWKLALVALACMPLMI---GCSLTRRLMINGYTKS---REGDTDDTIVTEA 902
Query: 214 IGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWYT 273
+ NVRTV + +E V +++AAL + + G+ G G + + +AL WY
Sbjct: 903 LSNVRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYG 962
Query: 274 SVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSKK 333
S ++ K A + ++++ + G+A + A+A+A +F +I+R
Sbjct: 963 SKLIDKGEAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDR-VPDVD 1021
Query: 334 SSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTVV 393
+ G K I++ +V F Y +RP + ++N+ L+G +G GKSTV+
Sbjct: 1022 IEQAGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTVI 1081
Query: 394 SLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDATL 453
++ RFYE SG I ++ D+ LD+ R+ I +V QEP LF+ +++ENI Y ++ AT
Sbjct: 1082 QMLARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYAREGATD 1141
Query: 454 EELKRAVK 461
EE++ A +
Sbjct: 1142 EEVEEAAR 1149
Score = 38.5 bits (88), Expect = 0.037
Identities = 16/42 (38%), Positives = 27/42 (64%)
Query: 15 VSMLKLFSFADSYDYVLMFIGSIGAIVHGASVPIFFIFFGKL 56
V +++F +AD+ D VLM G+ A+ GA +P+F FG++
Sbjct: 55 VGPIEIFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRI 96
>MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprotein
C)
Length = 1268
Score = 172 bits (436), Expect = 2e-42
Identities = 101/313 (32%), Positives = 166/313 (52%), Gaps = 8/313 (2%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRK----AYVRAGE 208
++ FI+G +IGF WQ++LV + VP + L Y++ + + K AY AG
Sbjct: 181 VATFISGVSIGFYMCWQLTLVMMITVP-LQLGS---MYLSAKHLNRATKNEMSAYSNAGG 236
Query: 209 IAEEVIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWAL 268
+A EVI +RTV AF + + Y L + G + + + ++F A+
Sbjct: 237 MANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAV 296
Query: 269 LVWYTSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERD 328
WY + + + G F V+I LG+AAP + A A+ A + IF++I+ +
Sbjct: 297 AFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHE 356
Query: 329 TVSKKSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSG 388
K +S G+ K+ G + F+ + F+YP+RP++ I ++ ++ G+ VALVG SG G
Sbjct: 357 PEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCG 416
Query: 389 KSTVVSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGK 448
KST + L+ RFY +G I LD I+E +++WLR IG+V QEP +F ++ ENI G
Sbjct: 417 KSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGD 476
Query: 449 DDATLEELKRAVK 461
T ++++ A K
Sbjct: 477 VLITDQDIEEACK 489
Score = 130 bits (328), Expect = 5e-30
Identities = 85/307 (27%), Positives = 148/307 (47%), Gaps = 1/307 (0%)
Query: 153 ISRFIAGFTIGFVRVWQISLVTLSIVPAIALAGGCYAYVTIGLIAKVRKAYVRAGEIAEE 212
I G + F W ++ + L+ + + A + + + A + E
Sbjct: 835 IVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTE 894
Query: 213 VIGNVRTVQAFAGEERAVRSYKAALMKTYVNGRKAGLAKGLGLGSMHCVLFLSWALLVWY 272
I N +TVQA +E ++ AA + GL + L + ++A+ +
Sbjct: 895 SISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMF 954
Query: 273 TSVVVHKNIANGGESFTTMLNVVISGLSLGQAAPDISAFIRAKAAAYPIFEMIERDTVSK 332
++ N + F + + ++ +S+ AA ++RA+ +A +F MI + +V
Sbjct: 955 GLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVID 1014
Query: 333 KSSKTGRKLSKLDGHIQFNDVCFSYPSRPDVGIFTNLNLDIPAGKIVALVGGSGSGKSTV 392
TG + G+I V F+YP+R + N+ G+ VALVG SG GKST
Sbjct: 1015 NRGLTG-DTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTT 1073
Query: 393 VSLIERFYEPISGQILLDKNDIRELDLKWLRQQIGLVNQEPALFATSIKENILYGKDDAT 452
+ LIER+Y+ + G + +D +DIR+L +K LR I LV QEP LF +I+ENI YG ++ T
Sbjct: 1074 IQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENIT 1133
Query: 453 LEELKRA 459
+++++A
Sbjct: 1134 QDQVEKA 1140
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.327 0.142 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,278,164
Number of Sequences: 164201
Number of extensions: 2118630
Number of successful extensions: 9993
Number of sequences better than 10.0: 899
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 8644
Number of HSP's gapped (non-prelim): 1198
length of query: 461
length of database: 59,974,054
effective HSP length: 114
effective length of query: 347
effective length of database: 41,255,140
effective search space: 14315533580
effective search space used: 14315533580
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 67 (30.4 bits)
Medicago: description of AC087771.6