BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC147363.5 - phase: 0
(433 letters)
Database: nr
2,540,612 sequences; 863,360,394 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gb|AAN15400.1| putative hydroxymethylglutaryl-CoA lyase [Arabido... 629 e-179
gb|AAK15568.1| putative hydroxymethylglutaryl-CoA lyase [Arabido... 629 e-179
dbj|BAD81168.1| putative hydroxymethylglutaryl-CoA lyase [Oryza ... 496 e-139
ref|NP_912924.1| unnamed protein product [Oryza sativa (japonica... 493 e-138
ref|NP_850088.1| hydroxymethylglutaryl-CoA lyase, putative / 3-h... 433 e-120
gb|AAH24194.2| HMGCLL1 protein [Homo sapiens] 404 e-111
ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lya... 402 e-110
ref|XP_419903.1| PREDICTED: similar to HMGCLL1 protein [Gallus g... 402 e-110
gb|AAL89669.1| hydroxymethylglutaryl-CoA lyase [Takifugu rubripes] 402 e-110
gb|AAH72247.1| MGC82338 protein [Xenopus laevis] 401 e-110
gb|AAH46023.1| Similar to 3-hydroxymethyl-3-methylglutaryl-Coenz... 401 e-110
ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-methylg... 400 e-110
ref|XP_417834.1| PREDICTED: similar to hydroxymethylglutaryl-CoA... 400 e-110
emb|CAG09900.1| unnamed protein product [Tetraodon nigroviridis] 400 e-110
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA l... 398 e-109
gb|AAH25440.1| Hmgcl protein [Mus musculus] 395 e-108
ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Ra... 395 e-108
ref|XP_638884.1| hydroxymethylglutaryl-CoA lyase [Dictyostelium ... 394 e-108
ref|NP_032280.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mu... 393 e-108
gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase 390 e-107
>gb|AAN15400.1| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gi|22136060|gb|AAM91612.1| putative
hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gi|30683260|ref|NP_850087.1| hydroxymethylglutaryl-CoA
lyase, putative / 3-hydroxy-3-methylglutarate-CoA lyase,
putative / HMG-CoA lyase, putative [Arabidopsis
thaliana] gi|7436675|pir||T02655
hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) -
Arabidopsis thaliana
Length = 433
Score = 629 bits (1621), Expect = e-179
Identities = 316/434 (72%), Positives = 363/434 (82%), Gaps = 2/434 (0%)
Query: 1 MSSLEEPLGHDKLPSMSTMDRVQRFSSGCCRPQVDNLGMGNCFIEGRSCSTSNSCNEDNE 60
MSSLEEPL DKLPSMSTMDR+QRFSSG CRP+ D++GMG+ +IEGR C+TSNSC +D++
Sbjct: 1 MSSLEEPLSFDKLPSMSTMDRIQRFSSGACRPR-DDVGMGHRWIEGRDCTTSNSCIDDDK 59
Query: 61 DYTAETYPWKRQTRDMSRGDSFSPRTMTTGRNTLKSGIVDNSFYTSDYQYSQKRNNKDMQ 120
+ E++PW+R TR +S G+ GR + SG + S + +YS N
Sbjct: 60 SFAKESFPWRRHTRKLSEGEHMFRNISFAGRTSTVSGTLRESKSFKEQKYSTFSNENGTS 119
Query: 121 DMAYKFMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSP 180
++ K KG+P+FVKIVEVGPRDGLQNEKNIVPT VK+ELI RL S+GL V+EATSFVSP
Sbjct: 120 HISNKISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSP 179
Query: 181 KWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNI 240
KWVPQLADAKDVM AV+ L G RLPVLTPNLKGF+AAV+AGA+EVA+FASASESFS SNI
Sbjct: 180 KWVPQLADAKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNI 239
Query: 241 NCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFE 300
NC+IEESL RYR V AAKE S+PVRGYVSCVVGCPVEGPV PSKVAYV K LYDMGCFE
Sbjct: 240 NCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFE 299
Query: 301 ISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSS 360
ISLGDTIG+GTPG+VVPML AVMA+VP +KLAVHFHDTYGQ+L NILVSLQMGIS VDSS
Sbjct: 300 ISLGDTIGIGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIVDSS 359
Query: 361 VAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTA 420
+AGLGGCPYAKGASGNVATEDVVYMLNGLG+ TNVD+GKL++AGDFI K LGRP+GSK A
Sbjct: 360 IAGLGGCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGSKAA 419
Query: 421 IALN-RVTADASKI 433
+ALN R+TADASKI
Sbjct: 420 VALNRRITADASKI 433
>gb|AAK15568.1| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gi|11935189|gb|AAG42010.1| putative
hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gi|20197286|gb|AAC32247.2| putative
hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gi|18401240|ref|NP_565629.1| hydroxymethylglutaryl-CoA
lyase, putative / 3-hydroxy-3-methylglutarate-CoA lyase,
putative / HMG-CoA lyase, putative [Arabidopsis
thaliana]
Length = 468
Score = 629 bits (1621), Expect = e-179
Identities = 316/434 (72%), Positives = 363/434 (82%), Gaps = 2/434 (0%)
Query: 1 MSSLEEPLGHDKLPSMSTMDRVQRFSSGCCRPQVDNLGMGNCFIEGRSCSTSNSCNEDNE 60
MSSLEEPL DKLPSMSTMDR+QRFSSG CRP+ D++GMG+ +IEGR C+TSNSC +D++
Sbjct: 36 MSSLEEPLSFDKLPSMSTMDRIQRFSSGACRPR-DDVGMGHRWIEGRDCTTSNSCIDDDK 94
Query: 61 DYTAETYPWKRQTRDMSRGDSFSPRTMTTGRNTLKSGIVDNSFYTSDYQYSQKRNNKDMQ 120
+ E++PW+R TR +S G+ GR + SG + S + +YS N
Sbjct: 95 SFAKESFPWRRHTRKLSEGEHMFRNISFAGRTSTVSGTLRESKSFKEQKYSTFSNENGTS 154
Query: 121 DMAYKFMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSP 180
++ K KG+P+FVKIVEVGPRDGLQNEKNIVPT VK+ELI RL S+GL V+EATSFVSP
Sbjct: 155 HISNKISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSP 214
Query: 181 KWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNI 240
KWVPQLADAKDVM AV+ L G RLPVLTPNLKGF+AAV+AGA+EVA+FASASESFS SNI
Sbjct: 215 KWVPQLADAKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNI 274
Query: 241 NCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFE 300
NC+IEESL RYR V AAKE S+PVRGYVSCVVGCPVEGPV PSKVAYV K LYDMGCFE
Sbjct: 275 NCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFE 334
Query: 301 ISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSS 360
ISLGDTIG+GTPG+VVPML AVMA+VP +KLAVHFHDTYGQ+L NILVSLQMGIS VDSS
Sbjct: 335 ISLGDTIGIGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIVDSS 394
Query: 361 VAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTA 420
+AGLGGCPYAKGASGNVATEDVVYMLNGLG+ TNVD+GKL++AGDFI K LGRP+GSK A
Sbjct: 395 IAGLGGCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGSKAA 454
Query: 421 IALN-RVTADASKI 433
+ALN R+TADASKI
Sbjct: 455 VALNRRITADASKI 468
>dbj|BAD81168.1| putative hydroxymethylglutaryl-CoA lyase [Oryza sativa (japonica
cultivar-group)]
Length = 419
Score = 496 bits (1277), Expect = e-139
Identities = 253/334 (75%), Positives = 283/334 (83%), Gaps = 2/334 (0%)
Query: 102 SFYTSDYQYSQKRNNKDMQDMAYKFMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELI 161
S +Y+Y + + + K + +P VKIVEVGPRDGLQNEKNIVPT VKIELI
Sbjct: 86 SLNPQNYRYFSSSSGQQSIGIGNKIIHDLPRSVKIVEVGPRDGLQNEKNIVPTHVKIELI 145
Query: 162 HRLASTGLSVIEATSFVSPKWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAG 221
RLA++GLSV+EATSFVSPKWVPQLADAKDVM V N+ G+ LPVLTPNLKGFEAAVAAG
Sbjct: 146 QRLATSGLSVVEATSFVSPKWVPQLADAKDVMDVVRNIEGVSLPVLTPNLKGFEAAVAAG 205
Query: 222 AREVAVFASASESFSKSNINCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPV 281
A+EVAVFASASE+FSKSNINC+I+ESL+RY+ V AAKEL IP+RGYVSCVVGCPVEG V
Sbjct: 206 AKEVAVFASASEAFSKSNINCTIKESLARYKDVALAAKELKIPMRGYVSCVVGCPVEGYV 265
Query: 282 PPSKVAYVAKALYDMGCFEISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQ 341
PPS VA+VAK LYDMGC+E+SLGDTIGVGTPGTVVPML AVM VP EKLAVHFHDTYGQ
Sbjct: 266 PPSNVAHVAKELYDMGCYEVSLGDTIGVGTPGTVVPMLEAVMFFVPKEKLAVHFHDTYGQ 325
Query: 342 SLPNILVSLQMGISAVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLM 401
SL NIL+SLQMG+S VDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGI TNVD+GK+M
Sbjct: 326 SLSNILISLQMGVSVVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGISTNVDLGKVM 385
Query: 402 SAGDFIGKQLGRPSGSKTAIALNR--VTADASKI 433
+AG+FI LGR SGSK AIAL TA+ASK+
Sbjct: 386 AAGEFICNHLGRQSGSKAAIALGSKVATANASKL 419
>ref|NP_912924.1| unnamed protein product [Oryza sativa (japonica cultivar-group)]
Length = 407
Score = 493 bits (1268), Expect = e-138
Identities = 252/325 (77%), Positives = 279/325 (85%), Gaps = 2/325 (0%)
Query: 111 SQKRNNKDMQDMAYKFMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLS 170
S +N + K + +P VKIVEVGPRDGLQNEKNIVPT VKIELI RLA++GLS
Sbjct: 83 SSSSDNPASIGIGNKIIHDLPRSVKIVEVGPRDGLQNEKNIVPTHVKIELIQRLATSGLS 142
Query: 171 VIEATSFVSPKWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFAS 230
V+EATSFVSPKWVPQLADAKDVM V N+ G+ LPVLTPNLKGFEAAVAAGA+EVAVFAS
Sbjct: 143 VVEATSFVSPKWVPQLADAKDVMDVVRNIEGVSLPVLTPNLKGFEAAVAAGAKEVAVFAS 202
Query: 231 ASESFSKSNINCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVA 290
ASE+FSKSNINC+I+ESL+RY+ V AAKEL IP+RGYVSCVVGCPVEG VPPS VA+VA
Sbjct: 203 ASEAFSKSNINCTIKESLARYKDVALAAKELKIPMRGYVSCVVGCPVEGYVPPSNVAHVA 262
Query: 291 KALYDMGCFEISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSL 350
K LYDMGC+E+SLGDTIGVGTPGTVVPML AVM VP EKLAVHFHDTYGQSL NIL+SL
Sbjct: 263 KELYDMGCYEVSLGDTIGVGTPGTVVPMLEAVMFFVPKEKLAVHFHDTYGQSLSNILISL 322
Query: 351 QMGISAVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQ 410
QMG+S VDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGI TNVD+GK+M+AG+FI
Sbjct: 323 QMGVSVVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGISTNVDLGKVMAAGEFICNH 382
Query: 411 LGRPSGSKTAIALNR--VTADASKI 433
LGR SGSK AIAL TA+ASK+
Sbjct: 383 LGRQSGSKAAIALGSKVATANASKL 407
>ref|NP_850088.1| hydroxymethylglutaryl-CoA lyase, putative /
3-hydroxy-3-methylglutarate-CoA lyase, putative /
HMG-CoA lyase, putative [Arabidopsis thaliana]
Length = 355
Score = 433 bits (1113), Expect = e-120
Identities = 217/316 (68%), Positives = 252/316 (79%), Gaps = 1/316 (0%)
Query: 1 MSSLEEPLGHDKLPSMSTMDRVQRFSSGCCRPQVDNLGMGNCFIEGRSCSTSNSCNEDNE 60
MSSLEEPL DKLPSMSTMDR+QRFSSG CRP+ D++GMG+ +IEGR C+TSNSC +D++
Sbjct: 36 MSSLEEPLSFDKLPSMSTMDRIQRFSSGACRPR-DDVGMGHRWIEGRDCTTSNSCIDDDK 94
Query: 61 DYTAETYPWKRQTRDMSRGDSFSPRTMTTGRNTLKSGIVDNSFYTSDYQYSQKRNNKDMQ 120
+ E++PW+R TR +S G+ GR + SG + S + +YS N
Sbjct: 95 SFAKESFPWRRHTRKLSEGEHMFRNISFAGRTSTVSGTLRESKSFKEQKYSTFSNENGTS 154
Query: 121 DMAYKFMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSP 180
++ K KG+P+FVKIVEVGPRDGLQNEKNIVPT VK+ELI RL S+GL V+EATSFVSP
Sbjct: 155 HISNKISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSP 214
Query: 181 KWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNI 240
KWVPQLADAKDVM AV+ L G RLPVLTPNLKGF+AAV+AGA+EVA+FASASESFS SNI
Sbjct: 215 KWVPQLADAKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNI 274
Query: 241 NCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFE 300
NC+IEESL RYR V AAKE S+PVRGYVSCVVGCPVEGPV PSKVAYV K LYDMGCFE
Sbjct: 275 NCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFE 334
Query: 301 ISLGDTIGVGTPGTVV 316
ISLGDTIG+GTPG V
Sbjct: 335 ISLGDTIGIGTPGNFV 350
>gb|AAH24194.2| HMGCLL1 protein [Homo sapiens]
Length = 340
Score = 404 bits (1038), Expect = e-111
Identities = 195/296 (65%), Positives = 240/296 (80%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
+ G+PEFVKIVEVGPRDGLQNEK IVPTD+KIE I+RL+ TGLSVIE TSFVS +WVPQ+
Sbjct: 41 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 100
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD +VM+ +H G+R PVLTPNL+GF AVAAGA E++VF +ASESFSK NINCSIEE
Sbjct: 101 ADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEE 160
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S+ ++ V ++A+ ++IP RGYVSC +GCP EG + P KV V+K LY MGC+EISLGDT
Sbjct: 161 SMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDT 220
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG++ ML +VM +P LAVH HDTYGQ+L NIL +LQMGI+ VDS+V+GLGG
Sbjct: 221 IGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGG 280
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGNVATED++YMLNGLG+ T V++ K+M AGDFI K + + + SK A A
Sbjct: 281 CPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQA 336
>ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus] gi|22726241|gb|AAH37381.1|
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
[Mus musculus]
Length = 343
Score = 402 bits (1033), Expect = e-110
Identities = 195/296 (65%), Positives = 241/296 (80%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
+ G+PE+VKIVEVGPRDGLQNEK IVPTD+KIELI++L+ TGLSVIE TSFVS +WVPQ+
Sbjct: 41 LPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQM 100
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD +VM+ + G+R PVLTPNL+GF+ AVAAGA E+AVF +ASESFSK NINCSIEE
Sbjct: 101 ADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEE 160
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S+ R++ V +A+ + IPVRGYVSC +GCP EG + P KV V+K LY MGC+EISLGDT
Sbjct: 161 SMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDT 220
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG++ ML +VM +P LAVH HDTYGQ+L NIL +LQMGI+ VDS+V+GLGG
Sbjct: 221 IGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGG 280
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGNVATED++YMLNG+G+ T VD+ K+M AG+FI K + + + SK A A
Sbjct: 281 CPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVAQA 336
>ref|XP_419903.1| PREDICTED: similar to HMGCLL1 protein [Gallus gallus]
Length = 420
Score = 402 bits (1032), Expect = e-110
Identities = 196/294 (66%), Positives = 239/294 (80%)
Query: 129 GMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLAD 188
G+PE+VKIVEVGPRDGLQNEK IVPTD KIELI+RL+ TGL IE TSFVS KWVPQ+AD
Sbjct: 119 GLPEYVKIVEVGPRDGLQNEKVIVPTDTKIELINRLSKTGLPAIEVTSFVSSKWVPQMAD 178
Query: 189 AKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESL 248
K+VM+ + G++ PVLTPNLKGF +A+AAGA EV+VF +ASESFSK NINCSIEES+
Sbjct: 179 HKEVMRGIERHPGVQYPVLTPNLKGFHSAIAAGATEVSVFGAASESFSKMNINCSIEESI 238
Query: 249 SRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIG 308
++ V ++A+ ++IPVRGYVSC +GCP EG + P+KVA V+K LY MGC+EISLGDTIG
Sbjct: 239 EKFEEVAKSARNMNIPVRGYVSCALGCPYEGDITPAKVAEVSKRLYSMGCYEISLGDTIG 298
Query: 309 VGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCP 368
VGTPG++ ML AVM +P LAVH HDTYGQ+L NIL ++QMG++ VDSSVAGLGGCP
Sbjct: 299 VGTPGSMKRMLEAVMKEIPLSALAVHCHDTYGQALANILTAIQMGVAVVDSSVAGLGGCP 358
Query: 369 YAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
YAKGA+GNVATEDV+YMLNGLGI T V++ +M AG+FI L + + SK A A
Sbjct: 359 YAKGATGNVATEDVIYMLNGLGINTGVNLYTVMEAGNFICTALNKKTNSKVAQA 412
>gb|AAL89669.1| hydroxymethylglutaryl-CoA lyase [Takifugu rubripes]
Length = 325
Score = 402 bits (1032), Expect = e-110
Identities = 202/297 (68%), Positives = 236/297 (79%)
Query: 126 FMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQ 185
F + VKIVEVGPRDGLQNEK IVP + KI LI L+++GL VIEATSFVSPKWVPQ
Sbjct: 25 FSSAKLQSVKIVEVGPRDGLQNEKTIVPLETKIHLIDMLSASGLPVIEATSFVSPKWVPQ 84
Query: 186 LADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIE 245
+AD +VM+ + G+ PVLTPNLKGF+AAV+AGA EVA+F +ASE FSK NINCS++
Sbjct: 85 MADQVEVMKGISRKPGVSYPVLTPNLKGFQAAVSAGASEVAIFGAASELFSKKNINCSVD 144
Query: 246 ESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGD 305
ESL R+ V +AAKE +PVRGYVSCV+GCP EG V P+KVA+VAK LY MGC+EISLGD
Sbjct: 145 ESLQRFDEVMKAAKEAGVPVRGYVSCVLGCPYEGKVEPAKVAHVAKRLYSMGCYEISLGD 204
Query: 306 TIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLG 365
TIGVGTPG++ ML V VP LAVH HDTYGQ+L NILV+LQMG+S VDSSVAGLG
Sbjct: 205 TIGVGTPGSMCEMLKVVSREVPVSALAVHCHDTYGQALANILVALQMGVSVVDSSVAGLG 264
Query: 366 GCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
GCPYA+GASGNVATEDVVYML+GLGI+T VD+ K+M AG FI + L R S SK A A
Sbjct: 265 GCPYAQGASGNVATEDVVYMLHGLGIQTGVDLSKVMDAGAFICRSLNRKSNSKVAQA 321
>gb|AAH72247.1| MGC82338 protein [Xenopus laevis]
Length = 328
Score = 401 bits (1031), Expect = e-110
Identities = 201/297 (67%), Positives = 238/297 (79%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
++ P+ VKIVEVGPRDGLQNEK +VPTDVKI LI+ L+ GL IEATSFVSPKWVPQ+
Sbjct: 29 IQSFPKEVKIVEVGPRDGLQNEKTVVPTDVKIHLINMLSEAGLQAIEATSFVSPKWVPQM 88
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD K+VMQ + I PVLTPNL GF+AAV GA+EVA+F +ASE FSK NINCSI+E
Sbjct: 89 ADHKNVMQGIKKYPNISYPVLTPNLTGFQAAVECGAKEVAIFGAASELFSKKNINCSIDE 148
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
SL R++AV AKE +IPVRGYVSCV+GCP EG V PSKVA VA ++ MGC+EISLGDT
Sbjct: 149 SLQRFKAVITEAKEANIPVRGYVSCVLGCPYEGKVAPSKVAEVAYKMFSMGCYEISLGDT 208
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG + ML AV+ +VP + LAVH HDTYGQ+L NILV+LQMG+ VD+SVAGLGG
Sbjct: 209 IGVGTPGGMRDMLSAVLDVVPAKALAVHCHDTYGQALANILVALQMGVQVVDASVAGLGG 268
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIAL 423
CPYA+GASGNVATEDVVYML+GLGI+T +D+ KL AG FI K LG+ S SK + A+
Sbjct: 269 CPYAQGASGNVATEDVVYMLHGLGIQTGIDLKKLTEAGAFICKALGKKSHSKVSQAI 325
>gb|AAH46023.1| Similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Danio rerio]
gi|41055014|ref|NP_957509.1| similar to
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Danio rerio]
Length = 340
Score = 401 bits (1030), Expect = e-110
Identities = 202/295 (68%), Positives = 235/295 (79%)
Query: 128 KGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLA 187
+ +PE VKIVEVGPRDGLQNEK IVPT+VKI LI L+ GL VIEATSFVSPKWVPQ+A
Sbjct: 42 QALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLSEAGLPVIEATSFVSPKWVPQMA 101
Query: 188 DAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEES 247
D ++VM+ +H G+ PVLTPNLKGF+AAV AGA+EVA+F +ASE FSK NINCS+EES
Sbjct: 102 DQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEVAIFGAASELFSKKNINCSVEES 161
Query: 248 LSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTI 307
L R+ V AAK+ + VRGYVSCV+GCP EG V PSKVA VAK LY MGC+E+SLGDTI
Sbjct: 162 LVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSKVAEVAKRLYSMGCYEVSLGDTI 221
Query: 308 GVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGC 367
GVGTPG + ML AV +P E LAVH HDTYGQ+L NILV+LQ G+S VDSSVAGLGGC
Sbjct: 222 GVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALANILVALQNGVSVVDSSVAGLGGC 281
Query: 368 PYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
PYA+GASGNVATEDVVYML+GLGI T VD+ +L+ AG FI + R + SK A A
Sbjct: 282 PYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGSFICHSINRRTNSKVAQA 336
>ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
Length = 433
Score = 400 bits (1029), Expect = e-110
Identities = 193/296 (65%), Positives = 238/296 (80%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
+ G+PE+VKIVEVGPRDGLQNEK IVPTD+KIE I++L+ TGLSVIE TSFVS +WVPQ+
Sbjct: 131 LSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSSRWVPQM 190
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD +VM +H G+R PVL PNL+G + AVAAGA E+AVF +ASESFSK NINCSIEE
Sbjct: 191 ADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNINCSIEE 250
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S+ R+ V +A+ ++IPVRGYVSC +GCP EG + P KV V+K LY MGC+EISLGDT
Sbjct: 251 SMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYEISLGDT 310
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
+GVGTPG++ ML +VM +P LAVH HDTYGQ+L NIL +LQMGI+ VDS+V+GLGG
Sbjct: 311 VGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGG 370
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGNVATED++YMLNG+G+ T VD+ K+M AGDFI K + + + SK A A
Sbjct: 371 CPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVAQA 426
>ref|XP_417834.1| PREDICTED: similar to hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
- chicken [Gallus gallus]
Length = 319
Score = 400 bits (1029), Expect = e-110
Identities = 200/296 (67%), Positives = 238/296 (79%)
Query: 131 PEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAK 190
P+ VK+VEVGPRDGLQNEK++VPT VKI LI L+ TGL VIEATSFVSP+WVPQ+AD
Sbjct: 24 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 83
Query: 191 DVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSR 250
+VMQ ++ L G+ PVLTPNLKGF+AAVAAGA+EV++F +ASE F+K NINCSIEESL R
Sbjct: 84 EVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLER 143
Query: 251 YRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVG 310
+ V AA+ SIPVRGYVSCV+GCP EG + +KVA V+K +Y MGC+EISLGDTIG+G
Sbjct: 144 FSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDTIGIG 203
Query: 311 TPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYA 370
TPG++ ML AVM VP LAVH HDTYGQ+L NILV+LQMG+S VD+SVAGLGGCPYA
Sbjct: 204 TPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYA 263
Query: 371 KGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIALNRV 426
+GASGNVATED+VYMLNGLGI T VD+ KLM G FI L R + SK + A R+
Sbjct: 264 QGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 319
>emb|CAG09900.1| unnamed protein product [Tetraodon nigroviridis]
Length = 337
Score = 400 bits (1029), Expect = e-110
Identities = 202/293 (68%), Positives = 236/293 (79%)
Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
+PE VKIVEVGPRDGLQNEK IVP++ KI LI L+++GL VIEATSFVSPKWVPQ+AD
Sbjct: 41 LPEKVKIVEVGPRDGLQNEKTIVPSETKIHLIDLLSASGLPVIEATSFVSPKWVPQMADQ 100
Query: 190 KDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLS 249
+VM+ + G+ PVLTPNLKGF+AAV AGA EVA+F +ASE FSK NINCS++ESL
Sbjct: 101 VEVMKGISRRPGVSYPVLTPNLKGFQAAVQAGASEVAIFGAASELFSKKNINCSVDESLQ 160
Query: 250 RYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGV 309
R+ V +AAKE +PVRGYVSCV+GCP EG V P KVA+VAK LY MGC+EISLGDTIGV
Sbjct: 161 RFDEVMKAAKEAGVPVRGYVSCVLGCPYEGKVEPVKVAHVAKRLYAMGCYEISLGDTIGV 220
Query: 310 GTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPY 369
GTPG++ ML V VP LAVH HDTYGQ+L NILV+LQMG+S VDSSVAGLGGCPY
Sbjct: 221 GTPGSMRDMLEVVSREVPVSALAVHCHDTYGQALANILVALQMGVSVVDSSVAGLGGCPY 280
Query: 370 AKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
A+GASGNVATEDVVYML+GLGI+T VD+ K+M AG FI + L R + SK A A
Sbjct: 281 AQGASGNVATEDVVYMLHGLGIQTGVDLSKVMDAGAFICRSLNRRTNSKVAQA 333
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase)
Length = 298
Score = 398 bits (1023), Expect = e-109
Identities = 199/296 (67%), Positives = 237/296 (79%)
Query: 131 PEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAK 190
P+ VK+VEVGPRDGLQNEK++VPT VKI LI L+ TGL VIEATSFVSP+WVPQ+AD
Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62
Query: 191 DVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSR 250
+VMQ ++ L G+ PVLTPNLKGF+AAVAAGA+EV++F +ASE F+K NINCSIEESL R
Sbjct: 63 EVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLER 122
Query: 251 YRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVG 310
+ V AA+ SIPVRGYVSCV+GCP EG + +KVA V+K +Y MGC+EISLGD IG+G
Sbjct: 123 FSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGIG 182
Query: 311 TPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYA 370
TPG++ ML AVM VP LAVH HDTYGQ+L NILV+LQMG+S VD+SVAGLGGCPYA
Sbjct: 183 TPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYA 242
Query: 371 KGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIALNRV 426
+GASGNVATED+VYMLNGLGI T VD+ KLM G FI L R + SK + A R+
Sbjct: 243 QGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>gb|AAH25440.1| Hmgcl protein [Mus musculus]
Length = 325
Score = 395 bits (1015), Expect = e-108
Identities = 201/296 (67%), Positives = 232/296 (77%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
M +P+ VKIVEVGPRDGLQNEK+IVPT VKI LI L+ GL VIEATSFVSPKWVPQ+
Sbjct: 26 MGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPKWVPQM 85
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD DV++ + GI PVLTPN+KGFE AVAAGA+EV+VF + SE F++ N NCSIEE
Sbjct: 86 ADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEE 145
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S R+ V +AA+ SI VRGYVSC +GCP EG V P+KVA VAK LY MGC+EISLGDT
Sbjct: 146 SFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDT 205
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG + ML AVM VP LAVH HDTYGQ+L N LV+LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGG 265
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGN+ATED+VYMLNGLGI T V++ KL+ AGDFI + L R + SK A A
Sbjct: 266 CPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321
>ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gi|1743378|emb|CAA71148.1| 3-hydroxy-3-methylglutaryl
CoA lyase [Rattus norvegicus] gi|38511566|gb|AAH61797.1|
3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus
norvegicus] gi|2495261|sp|P97519|HMGCL_RAT
Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
(HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA
lyase)
Length = 325
Score = 395 bits (1014), Expect = e-108
Identities = 199/296 (67%), Positives = 234/296 (78%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
M +P+ VKIVEVGPRDGLQNEK+IVPT VKI+LI L+ GL VIEATSFVSPKWVPQ+
Sbjct: 26 MGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLIDMLSEAGLPVIEATSFVSPKWVPQM 85
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD DV++ + GI PVLTPN+KGFE AVAAGA+EV++F +ASE F++ N+NCSIEE
Sbjct: 86 ADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSIFGAASELFTRKNVNCSIEE 145
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S R+ V +AA+ SI VRGYVSC +GCP EG V P+KVA VAK LY MGC+EISLGDT
Sbjct: 146 SFQRFDGVMQAARAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDT 205
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG + ML AV+ VP LAVH HDTYGQ+L N LV+LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGG 265
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGN+ATED+VYML GLGI T V++ KL+ AGDFI + L R + SK A A
Sbjct: 266 CPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321
>ref|XP_638884.1| hydroxymethylglutaryl-CoA lyase [Dictyostelium discoideum]
gi|60467499|gb|EAL65521.1| hydroxymethylglutaryl-CoA
lyase [Dictyostelium discoideum]
Length = 406
Score = 394 bits (1012), Expect = e-108
Identities = 198/321 (61%), Positives = 247/321 (76%), Gaps = 1/321 (0%)
Query: 111 SQKRNNKDMQDMAYKFMKG-MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGL 169
S NNK+ + ++ G PE+VKIVEVGPRDGLQNEK IVPT KI+LI+RLA TGL
Sbjct: 30 SLNNNNKENEFKRFQNRFGPFPEYVKIVEVGPRDGLQNEKIIVPTVDKIQLINRLAQTGL 89
Query: 170 SVIEATSFVSPKWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFA 229
SV+EATSFVSPKWVPQ+AD K+V++ + + G+ P LTPN++GF AA+ AGA+E+A+FA
Sbjct: 90 SVVEATSFVSPKWVPQMADNKEVLRGIEKVEGVSYPCLTPNIQGFRAALDAGAKEIALFA 149
Query: 230 SASESFSKSNINCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYV 289
+ASESFSK NIN +IEESL+RY+ V AA+E I VRGYVSCV+GCP E VP SKV YV
Sbjct: 150 AASESFSKKNINATIEESLARYKDVCDAARENGIKVRGYVSCVLGCPYEQNVPISKVVYV 209
Query: 290 AKALYDMGCFEISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVS 349
+K LY+ GC+EISLGDTIG+GTPG +L A+ +P +AVHFHDTYGQ+L NIL S
Sbjct: 210 SKKLYEFGCYEISLGDTIGIGTPGATHKLLQAMSQAIPMSAIAVHFHDTYGQALANILTS 269
Query: 350 LQMGISAVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGK 409
LQ GIS VDSSV+GLGGCPYAKGA+GNVATEDV+YM+ LGI NVD+ KLM +I K
Sbjct: 270 LQFGISTVDSSVSGLGGCPYAKGATGNVATEDVLYMMKDLGINCNVDMNKLMDVSLWISK 329
Query: 410 QLGRPSGSKTAIALNRVTADA 430
+L R SK ++AL+ +++
Sbjct: 330 KLNRSPSSKVSLALSHKASNS 350
>ref|NP_032280.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gi|1292952|gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA
lyase
Length = 325
Score = 393 bits (1010), Expect = e-108
Identities = 200/296 (67%), Positives = 232/296 (77%)
Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
M +P+ VKIVEVGPRDGLQNEK+IVPT VKI LI ++ GL VIEATSFVSPKWVPQ+
Sbjct: 26 MGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDIVSEAGLPVIEATSFVSPKWVPQM 85
Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
AD DV++ + GI PVLTPN+KGFE AVAAGA+EV+VF + SE F++ N NCSIEE
Sbjct: 86 ADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEE 145
Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
S R+ V +AA+ SI VRGYVSC +GCP EG V P+KVA VAK LY MGC+EISLGDT
Sbjct: 146 SFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDT 205
Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
IGVGTPG + ML AVM VP LAVH HDTYGQ+L N LV+LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGG 265
Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
CPYAKGASGN+ATED+VYMLNGLGI T V++ KL+ AGDFI + L R + SK A A
Sbjct: 266 CPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321
>gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase
Length = 292
Score = 390 bits (1003), Expect = e-107
Identities = 195/292 (66%), Positives = 233/292 (79%)
Query: 135 KIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAKDVMQ 194
+ +EVGPRDGLQNEK++VPT VKI LI L+ TGL VIEATSFVSP+WVPQ+AD +VMQ
Sbjct: 1 EFLEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHAEVMQ 60
Query: 195 AVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSRYRAV 254
++ L G+ PVLTPNLKGF+AAVAAGA+EV++F +ASE F+K NINCSIEESL R+ V
Sbjct: 61 GINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLERFSEV 120
Query: 255 TRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVGTPGT 314
AA+ SIPVRGYVSCV+GCP EG + +KVA V+K +Y MGC+EISLGD IG+GTPG+
Sbjct: 121 MNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGIGTPGS 180
Query: 315 VVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYAKGAS 374
+ ML AVM VP LAVH HDTYGQ+L NILV+LQMG+S VD+SVAGLGGCPYA+GAS
Sbjct: 181 MKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYAQGAS 240
Query: 375 GNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIALNRV 426
GNVATED+VYMLNGLGI T VD+ KLM G FI L R + SK + A R+
Sbjct: 241 GNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 292
Database: nr
Posted date: Jul 5, 2005 12:34 AM
Number of letters in database: 863,360,394
Number of sequences in database: 2,540,612
Lambda K H
0.316 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 697,458,628
Number of Sequences: 2540612
Number of extensions: 29009694
Number of successful extensions: 88610
Number of sequences better than 10.0: 755
Number of HSP's better than 10.0 without gapping: 241
Number of HSP's successfully gapped in prelim test: 515
Number of HSP's that attempted gapping in prelim test: 87765
Number of HSP's gapped (non-prelim): 846
length of query: 433
length of database: 863,360,394
effective HSP length: 131
effective length of query: 302
effective length of database: 530,540,222
effective search space: 160223147044
effective search space used: 160223147044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 77 (34.3 bits)
Medicago: description of AC147363.5