BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146329.5 + phase: 0
(639 letters)
Database: nr
2,540,612 sequences; 863,360,394 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|P28723|FTHS_SPIOL Formate--tetrahydrofolate ligase (Formyltet... 1153 0.0
gb|AAM10111.1| 10-formyltetrahydrofolate synthetase [Arabidopsis... 1123 0.0
dbj|BAD38226.1| putative formate--tetrahydrofolate ligase [Oryza... 1097 0.0
ref|XP_635719.1| formate-dihydrofolate ligase [Dictyostelium dis... 888 0.0
ref|XP_510001.1| PREDICTED: methylenetetrahydrofolate dehydrogen... 845 0.0
sp|P11586|C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic ... 845 0.0
gb|AAH50420.1| Methylenetetrahydrofolate dehydrogenase 1 [Homo s... 844 0.0
gb|AAH09806.1| Methylenetetrahydrofolate dehydrogenase 1 [Homo s... 844 0.0
gb|AAH80885.1| Mthfd1-prov protein [Xenopus tropicalis] gi|56118... 842 0.0
emb|CAH91870.1| hypothetical protein [Pongo pygmaeus] 840 0.0
gb|AAL99693.1| C1-tetrahydrofolate synthase [Mus musculus] gi|19... 837 0.0
gb|AAH89800.1| Methylenetetrahydrofolate dehydrogenase (NADP+ de... 835 0.0
gb|AAH45019.1| Mthfd1-prov protein [Xenopus laevis] 835 0.0
ref|NP_620084.1| methylenetetrahydrofolate dehydrogenase 1 [Mus ... 835 0.0
ref|NP_071953.1| methylenetetrahydrofolate dehydrogenase (NADP+ ... 834 0.0
gb|AAH75779.1| Methylenetetrahydrofolate dehydrogenase (NADP+ de... 834 0.0
gb|AAH45396.1| Methylenetetrahydrofolate dehydrogenase (NADP+ de... 829 0.0
pir||A35367 methylenetetrahydrofolate dehydrogenase (NADP) (EC 1... 828 0.0
emb|CAG32567.1| hypothetical protein [Gallus gallus] 822 0.0
emb|CAG10709.1| unnamed protein product [Tetraodon nigroviridis] 816 0.0
>sp|P28723|FTHS_SPIOL Formate--tetrahydrofolate ligase (Formyltetrahydrofolate
synthetase) (10-formyletrahydrofolate synthetase) (FHS)
(FTHFS) gi|170145|gb|AAA34046.1|
10-formyltetrahydrofolate synthetase
Length = 637
Score = 1153 bits (2982), Expect = 0.0
Identities = 563/634 (88%), Positives = 609/634 (95%)
Query: 6 SSSVMRKLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDE 65
SS +RKL+V +PVP+DIDIAN+V+P+HI++IA LNL+P HYDLYGKYKAKVLLS LDE
Sbjct: 4 SSKTVRKLEVATPVPADIDIANAVEPLHIADIAADLNLSPRHYDLYGKYKAKVLLSVLDE 63
Query: 66 LQESKDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKG 125
+QE++DGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTC+RQPSQGPTFGIKG
Sbjct: 64 VQETQDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCLRQPSQGPTFGIKG 123
Query: 126 GAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPP 185
GAAGGGYSQVIPMDEFNLHLTGDIHAITA+NNLLAAAIDTR+FHESTQSDKALFNRLCPP
Sbjct: 124 GAAGGGYSQVIPMDEFNLHLTGDIHAITASNNLLAAAIDTRMFHESTQSDKALFNRLCPP 183
Query: 186 NKEGKRSFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFL 245
NKEGKR+F ++M RRLKK GI KTNPDDLTPEEV KFARLDIDPDSITWRRVMD+NDRFL
Sbjct: 184 NKEGKRTFCNIMHRRLKKLGIDKTNPDDLTPEEVTKFARLDIDPDSITWRRVMDVNDRFL 243
Query: 246 RKITVGQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVT 305
RKI+VGQGPDEKGMVRET FDISVASEIMAVLALTTSL DMRERLGKMVIGNSK+G+P+T
Sbjct: 244 RKISVGQGPDEKGMVRETGFDISVASEIMAVLALTTSLADMRERLGKMVIGNSKAGEPIT 303
Query: 306 ADDLGIGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP 365
ADDLG+GGALTVLMKDAI+PTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP
Sbjct: 304 ADDLGLGGALTVLMKDAINPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP 363
Query: 366 GGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDH 425
GGFVVTEAGFG+DIGTEKFMNIKCRYSGLTPQCAI+VAT+RALKMHGGGP VVAGKPLD
Sbjct: 364 GGFVVTEAGFGSDIGTEKFMNIKCRYSGLTPQCAIVVATVRALKMHGGGPQVVAGKPLDR 423
Query: 426 AYLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYD 485
AYLTENV LVEAGC NLARHI+N+KAYG+NV+VAIN FS+DT+AELNAVKKAA+DAGA+D
Sbjct: 424 AYLTENVGLVEAGCVNLARHIINTKAYGSNVVVAINMFSSDTEAELNAVKKAAMDAGAFD 483
Query: 486 AVICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKSYGASGVEY 545
AVIC+HHAHGG+GAVDLGIAVQKACEN TQPL+FLYPLDI IKEKIEAIAKSYGA+GVEY
Sbjct: 484 AVICTHHAHGGKGAVDLGIAVQKACENVTQPLRFLYPLDISIKEKIEAIAKSYGAAGVEY 543
Query: 546 SEQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIY 605
SEQAEKKIE+Y+KQGFS LPICMAKTQYSFS NAA KGAP+GFILPIRDVR SIGAGFIY
Sbjct: 544 SEQAEKKIEMYSKQGFSNLPICMAKTQYSFSHNAAEKGAPSGFILPIRDVRGSIGAGFIY 603
Query: 606 PLVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGLS 639
PLVGTMSTMPGLPTRPCF+DIDLDTTTG+VIGLS
Sbjct: 604 PLVGTMSTMPGLPTRPCFFDIDLDTTTGKVIGLS 637
>gb|AAM10111.1| 10-formyltetrahydrofolate synthetase [Arabidopsis thaliana]
gi|18403095|ref|NP_564571.1| formate--tetrahydrofolate
ligase / 10-formyltetrahydrofolate synthetase (THFS)
[Arabidopsis thaliana] gi|15451114|gb|AAK96828.1|
10-formyltetrahydrofolate synthetase [Arabidopsis
thaliana] gi|5921663|gb|AAD56290.1|
10-formyltetrahydrofolate synthetase [Arabidopsis
thaliana] gi|12322329|gb|AAG51185.1|
10-formyltetrahydrofolate synthetase [Arabidopsis
thaliana] gi|9454559|gb|AAF87882.1|
10-formyltetrahydrofolate synthetase [Arabidopsis
thaliana]
Length = 634
Score = 1123 bits (2904), Expect = 0.0
Identities = 545/633 (86%), Positives = 602/633 (95%)
Query: 7 SSVMRKLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDEL 66
SS RKL+VVSPVP+DIDIANSV+P+HISEIA LN+ P HYDLYGKYKAKVLLSA DEL
Sbjct: 2 SSSTRKLEVVSPVPADIDIANSVEPLHISEIAKDLNINPLHYDLYGKYKAKVLLSAFDEL 61
Query: 67 QESKDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGG 126
Q +DGYYVVVGGITPTPLGEGKSTTTVGLCQALGA+LDKKVVTC+RQPSQGPTFGIKGG
Sbjct: 62 QGQEDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAYLDKKVVTCLRQPSQGPTFGIKGG 121
Query: 127 AAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPN 186
AAGGGYSQVIPMDEFNLHLTGDIHAITA+NNLLAAAIDTRIFHE++QSDKALFNRLCPPN
Sbjct: 122 AAGGGYSQVIPMDEFNLHLTGDIHAITASNNLLAAAIDTRIFHETSQSDKALFNRLCPPN 181
Query: 187 KEGKRSFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLR 246
KEGKRSFSD+MFRRL K GISKT+P++LTPEE+ KFARLDIDP SITWRRVMD+NDRFLR
Sbjct: 182 KEGKRSFSDIMFRRLTKLGISKTSPEELTPEEIKKFARLDIDPASITWRRVMDVNDRFLR 241
Query: 247 KITVGQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTA 306
KIT+GQGP+EKGM RET FDISVASEIMAVLALTTSL DMRERLGKMVIGNSK+GDP+TA
Sbjct: 242 KITIGQGPEEKGMTRETGFDISVASEIMAVLALTTSLGDMRERLGKMVIGNSKAGDPITA 301
Query: 307 DDLGIGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPG 366
DDLG+GGALTVLMKDAI+PTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPG
Sbjct: 302 DDLGVGGALTVLMKDAINPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPG 361
Query: 367 GFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHA 426
GFVVTEAGFG+DIGTEKFMNIKCRYSGLTPQCAI+VAT+RALKMHGGGP VVAG+PLD A
Sbjct: 362 GFVVTEAGFGSDIGTEKFMNIKCRYSGLTPQCAIVVATVRALKMHGGGPDVVAGRPLDRA 421
Query: 427 YLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDA 486
Y++ENV+LVEAGC NLA+HI N+KAYG NVIVA+N F+TDT+AELNAV+K ++DAGA+DA
Sbjct: 422 YVSENVSLVEAGCVNLAKHISNTKAYGVNVIVAVNMFATDTEAELNAVRKFSMDAGAFDA 481
Query: 487 VICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKSYGASGVEYS 546
V+CSHHAH G+GAVDLGIAV+KAC+N TQPL+FLYPLDIGIK+KIEAIAKSYGASGVEYS
Sbjct: 482 VVCSHHAHSGKGAVDLGIAVEKACQNITQPLRFLYPLDIGIKDKIEAIAKSYGASGVEYS 541
Query: 547 EQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYP 606
+QAEK+IE+YT+QGFS LPICM+KTQYSFS +A+ KGAP+GF+LPIRDVR SIGAGFIYP
Sbjct: 542 DQAEKQIEMYTQQGFSNLPICMSKTQYSFSHDASKKGAPSGFVLPIRDVRGSIGAGFIYP 601
Query: 607 LVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGLS 639
LVGTMSTMPGLPTRPCFY+ID+DT TG+V GLS
Sbjct: 602 LVGTMSTMPGLPTRPCFYEIDIDTETGKVRGLS 634
>dbj|BAD38226.1| putative formate--tetrahydrofolate ligase [Oryza sativa (japonica
cultivar-group)]
Length = 639
Score = 1097 bits (2836), Expect = 0.0
Identities = 533/639 (83%), Positives = 596/639 (92%)
Query: 1 MTSSSSSSVMRKLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLL 60
MT+ S +R+LDV SPVP+DIDIAN+V P+ I++IA L L P H+DLYGKYKAKVLL
Sbjct: 1 MTTPKPSPTIRRLDVASPVPADIDIANAVSPLPIADIAAELGLRPEHFDLYGKYKAKVLL 60
Query: 61 SALDELQESKDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPT 120
S LDEL+ +DGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTC+RQPSQGPT
Sbjct: 61 SVLDELKGQQDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCLRQPSQGPT 120
Query: 121 FGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFN 180
FGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHE++QSDKALFN
Sbjct: 121 FGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHEASQSDKALFN 180
Query: 181 RLCPPNKEGKRSFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDI 240
RLCPPNKEGKR F+DVM RRL K GISKT+P++LTP+EV +FARLDIDP+SITWRRVMD+
Sbjct: 181 RLCPPNKEGKRRFADVMLRRLIKLGISKTDPNELTPDEVRRFARLDIDPESITWRRVMDV 240
Query: 241 NDRFLRKITVGQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKS 300
NDRFLRKIT+GQGPDEKGMVRET FDI+VASEIMAVLALTTSL DMRERLG+MVIGNSK+
Sbjct: 241 NDRFLRKITIGQGPDEKGMVRETGFDIAVASEIMAVLALTTSLADMRERLGRMVIGNSKA 300
Query: 301 GDPVTADDLGIGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIAL 360
G+P+TADDLG+GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIAL
Sbjct: 301 GEPITADDLGVGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIAL 360
Query: 361 KLVGPGGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAG 420
KLVG GG+VVTEAGFG+DIGTEKFM+IKCRYSGL PQCAIIVATIRALKMHGGGP VVAG
Sbjct: 361 KLVGKGGYVVTEAGFGSDIGTEKFMDIKCRYSGLMPQCAIIVATIRALKMHGGGPDVVAG 420
Query: 421 KPLDHAYLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALD 480
KPLDHAY++ENVALVEAGC NLA+HI N+K+YG NV+VAINKF++DT+AE++ V+ A+L
Sbjct: 421 KPLDHAYVSENVALVEAGCVNLAKHIANTKSYGVNVVVAINKFASDTEAEMDVVRNASLA 480
Query: 481 AGAYDAVICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKSYGA 540
AGA+DAV+C+HHAHGG+GAVDLG+AVQ+ACE+ PLKFLYPL+ GIKEKIE+IAK YGA
Sbjct: 481 AGAFDAVVCTHHAHGGKGAVDLGLAVQRACESQADPLKFLYPLESGIKEKIESIAKFYGA 540
Query: 541 SGVEYSEQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIG 600
SGVEYSEQAEK+IE+YTKQGFS LPICMAKTQYSFS + KGAP+GF+LPIRDVRASIG
Sbjct: 541 SGVEYSEQAEKQIEMYTKQGFSNLPICMAKTQYSFSHVPSMKGAPSGFVLPIRDVRASIG 600
Query: 601 AGFIYPLVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGLS 639
AGFIYPLVGTMSTMPGLPTRPCFY+ID+DT TG+V+GLS
Sbjct: 601 AGFIYPLVGTMSTMPGLPTRPCFYEIDVDTATGKVMGLS 639
>ref|XP_635719.1| formate-dihydrofolate ligase [Dictyostelium discoideum]
gi|60464052|gb|EAL62214.1| formate-dihydrofolate ligase
[Dictyostelium discoideum]
Length = 638
Score = 888 bits (2294), Expect = 0.0
Identities = 445/631 (70%), Positives = 518/631 (81%), Gaps = 3/631 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL+++ PVPSDI+IA+SV+P+ I IA + L D YGKYKAKV L ++ L+E+++
Sbjct: 8 KLNLIKPVPSDIEIASSVEPLPIKTIAKSIGLLEEEIDFYGKYKAKVSLEVIERLKETEN 67
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GI PTPLGEGKSTTT+GLCQALGA L KK CIRQPSQGPTFGIKGGAAGGG
Sbjct: 68 GNYVVVTGINPTPLGEGKSTTTIGLCQALGAHLGKKTFACIRQPSQGPTFGIKGGAAGGG 127
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCP-PNKEGK 190
YSQVIPM+EFNLH+TGDIHAITAANNLLAAAIDTRI HE TQ+D L+ RLCP +K+G
Sbjct: 128 YSQVIPMEEFNLHMTGDIHAITAANNLLAAAIDTRILHEGTQTDAQLWKRLCPVDSKDGS 187
Query: 191 RSFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITV 250
R F+ +M RRLKK GI KT+P+ LT EE++KF RLDIDP ITW RV+D NDRFLR I+V
Sbjct: 188 RKFAPIMLRRLKKLGIDKTDPNQLTEEEISKFVRLDIDPTRITWNRVLDTNDRFLRGISV 247
Query: 251 GQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLG 310
GQG +E+ R+T FDISVASEIMAVLAL TSL+DMRERLG+MV+G S+SG+P+TADDLG
Sbjct: 248 GQGKEEQRFERKTNFDISVASEIMAVLALCTSLSDMRERLGRMVVGPSRSGEPITADDLG 307
Query: 311 IGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVV 370
+GGALTVLMKDAI PTLMQTLEGTPVLVHAGPFANIAHGNSSI+AD+IALKL G G+VV
Sbjct: 308 VGGALTVLMKDAIMPTLMQTLEGTPVLVHAGPFANIAHGNSSIIADQIALKLAGKDGYVV 367
Query: 371 TEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTE 430
TEAGFGADIG EKF +IKCR SGL P CA+IVATIRALKMHGGGP VVAG PLD AY +E
Sbjct: 368 TEAGFGADIGAEKFFDIKCRSSGLKPNCAVIVATIRALKMHGGGPKVVAGTPLDKAYTSE 427
Query: 431 NVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICS 490
N+ L++ G +NLA HI N K +G V+VAINKF TD+DAE+N + +A+L AGA DAV+
Sbjct: 428 NIELLKKGVSNLAHHIKNLKKFGVGVVVAINKFHTDSDAEVNLLVEASLTAGANDAVMSD 487
Query: 491 HHAHGGRGAVDLGIAVQKACENATQP-LKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQ 548
H A GG GA+DL AV+KAC+ + K+LYPLD IKEKIE IAK YGA GVEYS +
Sbjct: 488 HWAEGGNGALDLANAVEKACKETNKDNFKYLYPLDKSIKEKIETIAKEIYGADGVEYSPE 547
Query: 549 AEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLV 608
A+ KI+LYT QGF LPICMAKT S S + KG PTGFILPIRDVRASIGAGFIYPLV
Sbjct: 548 ADDKIKLYTTQGFDKLPICMAKTHLSLSHDPERKGVPTGFILPIRDVRASIGAGFIYPLV 607
Query: 609 GTMSTMPGLPTRPCFYDIDLDTTTGQVIGLS 639
G+M+T+PGLPTRPCFY+ID+DT TG++IGLS
Sbjct: 608 GSMATIPGLPTRPCFYEIDIDTNTGKIIGLS 638
>ref|XP_510001.1| PREDICTED: methylenetetrahydrofolate dehydrogenase 1 [Pan
troglodytes]
Length = 999
Score = 845 bits (2184), Expect = 0.0
Identities = 426/627 (67%), Positives = 501/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +PVPSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 374 LNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 433
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 434 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 493
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + +G R
Sbjct: 494 SQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVDGVRR 552
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 553 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 612
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMAVLALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 613 APTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 672
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 673 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTE 732
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 733 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENL 792
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT++EL+ + + + + GA+DAV C+H
Sbjct: 793 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHW 852
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 853 AEGGKGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 911
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LPICMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 912 KAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 971
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 972 STMPGLPTRPCFYDIDLDPETEQVNGL 998
>sp|P11586|C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase)
[Includes: Methylenetetrahydrofolate dehydrogenase ;
Methenyltetrahydrofolate cyclohydrolase ;
Formyltetrahydrofolate synthetase ]
gi|307178|gb|AAA59574.1| MDMCSF (EC 1.5.1.5; EC 3.5.4.9;
EC 6.3.4.3)
Length = 935
Score = 845 bits (2182), Expect = 0.0
Identities = 426/627 (67%), Positives = 500/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +PVPSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 310 LNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 369
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 370 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 429
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 430 SQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVRR 488
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 489 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 548
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMAVLALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 549 APTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 608
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 609 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTE 668
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 669 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENL 728
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT++EL+ + + + + GA+DAV C+H
Sbjct: 729 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHW 788
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 789 AEGGKGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 847
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LPICMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 848 KAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 907
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 908 STMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH50420.1| Methylenetetrahydrofolate dehydrogenase 1 [Homo sapiens]
Length = 935
Score = 844 bits (2181), Expect = 0.0
Identities = 426/627 (67%), Positives = 500/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +PVPSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 310 LNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 369
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 370 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 429
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 430 SQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVRR 488
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 489 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 548
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMAVLALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 549 APTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 608
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 609 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTE 668
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 669 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENL 728
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT++EL+ + + + + GA+DAV C+H
Sbjct: 729 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDFISRLSREHGAFDAVKCTHW 788
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 789 AEGGKGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 847
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LPICMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 848 KAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 907
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 908 STMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH09806.1| Methylenetetrahydrofolate dehydrogenase 1 [Homo sapiens]
gi|13699868|ref|NP_005947.2| methylenetetrahydrofolate
dehydrogenase 1 [Homo sapiens]
Length = 935
Score = 844 bits (2181), Expect = 0.0
Identities = 426/627 (67%), Positives = 500/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +PVPSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 310 LNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 369
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 370 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 429
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 430 SQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVRR 488
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 489 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 548
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMAVLALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 549 APTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 608
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 609 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADQIALKLVGPEGFVVTE 668
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 669 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENL 728
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT++EL+ + + + + GA+DAV C+H
Sbjct: 729 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHW 788
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 789 AEGGKGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 847
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LPICMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 848 KAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 907
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 908 STMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH80885.1| Mthfd1-prov protein [Xenopus tropicalis]
gi|56118594|ref|NP_001008007.1| mthfd1-prov protein
[Xenopus tropicalis]
Length = 934
Score = 842 bits (2174), Expect = 0.0
Identities = 427/628 (67%), Positives = 491/628 (77%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL + PVPSDI+I+ S P I++I+ + L +LYG+ KAKVLLS L LQ +D
Sbjct: 308 KLHLKVPVPSDIEISRSCIPKPIAKISQEIGLLSEEVELYGQTKAKVLLSTLKRLQNRED 367
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L+ V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 368 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLNLNVFACVRQPSQGPTFGIKGGAAGGG 427
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQSDKAL+NRL P N G R
Sbjct: 428 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQSDKALYNRLVPSNN-GVR 486
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT EE+NKF RLDIDPD+ITW+RV+D NDRFLRKIT+G
Sbjct: 487 KFSDIQIRRLRRLGIEKTDPTALTEEEINKFVRLDIDPDTITWQRVLDTNDRFLRKITIG 546
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R T FDISVASEIMAVLALT L +MRERLGKMV+ +SK G+PV+ +DLG+
Sbjct: 547 QAPTEKGFTRTTQFDISVASEIMAVLALTDGLDNMRERLGKMVVASSKKGEPVSTEDLGV 606
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GAL VLMKDA+ P LMQTLEG PV VHAGPFANIAHGNSSI+ADKIALKLVGP GFVVT
Sbjct: 607 SGALAVLMKDALKPNLMQTLEGNPVFVHAGPFANIAHGNSSILADKIALKLVGPEGFVVT 666
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF +IKCRYSGL P ++VAT+RALKMHGGGP V AG PL Y EN
Sbjct: 667 EAGFGADIGMEKFFDIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGVPLPKEYTEEN 726
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE GC+NL + I N+ +G V+VA+N F TDT+AEL V A AGA+DAV C+H
Sbjct: 727 LDLVEKGCSNLRKQIENATTFGVPVVVAVNAFKTDTEAELELVCHIAKKAGAFDAVRCTH 786
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GAV L AVQ+A E A KFLY +++ + +KI IA K YGA +E +A+
Sbjct: 787 WAEGGKGAVALAQAVQRASE-APSDFKFLYDVELPVADKIRIIAQKIYGADNIELLPEAQ 845
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
KK ELYTKQGF LP+CMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 846 KKAELYTKQGFGNLPVCMAKTHLSLSHNPELKGVPTGFVLPIRDIRASVGAGFLYPLVGT 905
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD + QV GL
Sbjct: 906 MSTMPGLPTRPCFYDIDLDPVSEQVNGL 933
>emb|CAH91870.1| hypothetical protein [Pongo pygmaeus]
Length = 935
Score = 840 bits (2169), Expect = 0.0
Identities = 424/627 (67%), Positives = 496/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +P PSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 310 LNLKTPDPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 369
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTTVGL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 370 KYVVVTGITPTPLGEGKSTTTVGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 429
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHA TAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 430 SQVIPMEEFNLHLTGDIHAFTAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVRK 488
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 489 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 548
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMA LALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 549 APTEKGHTRTAQFDISVASEIMAALALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 608
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 609 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTE 668
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 669 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIEENL 728
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT+AEL+ + + + + GA+DAV C+H
Sbjct: 729 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTEAELDLISRLSREHGAFDAVKCTHW 788
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 789 AEGGNGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 847
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LP+CMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 848 KAEVYTKQGFGNLPVCMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 907
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 908 STMPGLPTRPCFYDIDLDPETQQVNGL 934
>gb|AAL99693.1| C1-tetrahydrofolate synthase [Mus musculus]
gi|19850913|gb|AAL99692.1| C1-tetrahydrofolate synthase
[Mus musculus] gi|26353766|dbj|BAC40513.1| unnamed
protein product [Mus musculus]
Length = 935
Score = 837 bits (2163), Expect = 0.0
Identities = 422/628 (67%), Positives = 497/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 309 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGIR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 488 KFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMRERLG+MV+ +SK G+P++ +DLG+
Sbjct: 548 QSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 608 SGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTDAEL+ V + + + GA+DAV C+H
Sbjct: 728 LDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + I++KI IA + YGA +E +A+
Sbjct: 788 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 907 MSTMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH89800.1| Methylenetetrahydrofolate dehydrogenase (NADP+ dependent),
methenyltetrahydrofolate cyclohydrolase,
formyltetrahydrofolate synthase [Rattus norvegicus]
Length = 935
Score = 835 bits (2158), Expect = 0.0
Identities = 421/628 (67%), Positives = 496/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 309 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 488 KFSDIQIRRLRRLGIEKTDPAALTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMR RLGKMV+ +SK G+P++ +DLG+
Sbjct: 548 QAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRARLGKMVVASSKKGEPISCEDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 608 SGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTDAEL+ + + + + GA+DAV C+H
Sbjct: 728 LDLVEKGFSNLRKQIENARMFGVPVVVAMNAFKTDTDAELDLIGRLSREHGAFDAVKCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 788 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSVEDKIRIIAQKIYGADDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 907 MSTMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH45019.1| Mthfd1-prov protein [Xenopus laevis]
Length = 934
Score = 835 bits (2157), Expect = 0.0
Identities = 422/628 (67%), Positives = 491/628 (77%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL + PVPSDI+I+ S P I++I+ + L +LYG+ KAKVLLS L LQ +D
Sbjct: 308 KLHLKVPVPSDIEISRSCIPKPIAKISEEIGLLSQEVELYGQTKAKVLLSTLKRLQNRED 367
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L+ V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 368 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLNLNVFACVRQPSQGPTFGIKGGAAGGG 427
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQSDKAL++RL P N G R
Sbjct: 428 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQSDKALYSRLVPSNN-GVR 486
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT EE+NKF RLDIDPD+ITW+RV+D NDRFLRKIT+G
Sbjct: 487 KFSDIQIRRLRRLGIEKTDPAALTEEEINKFVRLDIDPDTITWQRVLDTNDRFLRKITIG 546
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT L +MRERLGKMV+ +SK G+PV+ +DLG+
Sbjct: 547 QAPTEKGFTRTAQFDISVASEIMAVLALTDGLDNMRERLGKMVVASSKKGEPVSTEDLGV 606
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDA+ P LMQT+EG PV VHAGPFANIAHGNSSI+ADKIALKLVGP GFVVT
Sbjct: 607 SGALTVLMKDAVKPNLMQTMEGNPVFVHAGPFANIAHGNSSILADKIALKLVGPEGFVVT 666
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++V+T+RALKMHGGGP V AG PL Y EN
Sbjct: 667 EAGFGADIGMEKFFNIKCRYSGLRPHVVVLVSTVRALKMHGGGPTVTAGVPLPKEYTEEN 726
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ L+E GC+NL + I N+ +G V+VA+N F TDT+AEL+ V A AGA+DA+ C+H
Sbjct: 727 LDLIEKGCSNLRKQIENATIFGVPVVVAVNAFKTDTEAELDIVCDLAKKAGAFDAIRCTH 786
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GAV L AVQ+A + A KFLY + + I +KI IA K YGA +E +A+
Sbjct: 787 WADGGKGAVALAQAVQRASQ-APSNFKFLYDVQLPIADKIRIIAQKIYGADDIELLPEAQ 845
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
KK +LYTKQGF LP+CMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 846 KKADLYTKQGFGNLPVCMAKTHLSLSHNPELKGVPTGFVLPIRDIRASVGAGFLYPLVGT 905
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD + QV GL
Sbjct: 906 MSTMPGLPTRPCFYDIDLDPVSEQVNGL 933
>ref|NP_620084.1| methylenetetrahydrofolate dehydrogenase 1 [Mus musculus]
gi|14250204|gb|AAH08523.1| Methylenetetrahydrofolate
dehydrogenase 1 [Mus musculus]
gi|34921990|sp|Q922D8|C1TC_MOUSE C-1-tetrahydrofolate
synthase, cytoplasmic (C1-THF synthase) [Includes:
Methylenetetrahydrofolate dehydrogenase ;
Methenyltetrahydrofolate cyclohydrolase ;
Formyltetrahydrofolate synthetase ]
Length = 935
Score = 835 bits (2157), Expect = 0.0
Identities = 421/628 (67%), Positives = 496/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 309 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKYQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGIR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 488 KFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMRERLG+MV+ +SK G+P++ +DLG+
Sbjct: 548 QSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
G LTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 608 SGTLTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTDAEL+ V + + + GA+DAV C+H
Sbjct: 728 LDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + I++KI IA + YGA +E +A+
Sbjct: 788 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 907 MSTMPGLPTRPCFYDIDLDPETEQVNGL 934
>ref|NP_071953.1| methylenetetrahydrofolate dehydrogenase (NADP+ dependent),
methenyltetrahydrofolate cyclohydrolase,
formyltetrahydrofolate synthase [Rattus norvegicus]
gi|901850|gb|AAA74248.1| C1-tetrahydrofolate synthase
gi|1345633|sp|P27653|C1TC_RAT C-1-tetrahydrofolate
synthase, cytoplasmic (C1-THF synthase) [Includes:
Methylenetetrahydrofolate dehydrogenase ;
Methenyltetrahydrofolate cyclohydrolase ;
Formyltetrahydrofolate synthetase ]
Length = 935
Score = 834 bits (2154), Expect = 0.0
Identities = 420/628 (66%), Positives = 495/628 (77%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 309 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 488 KFSDIQIRRLRRLGIEKTDPAALTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMR RLGKMV+ +SK G+P++ +DLG+
Sbjct: 548 QAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRARLGKMVVASSKKGEPISCEDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 608 SGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTD EL+ + + + + GA+DAV C+H
Sbjct: 728 LDLVEKGFSNLRKQIENARMFGVPVVVAMNAFKTDTDTELDLIGRLSREHGAFDAVKCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 788 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSVEDKIRIIAQKIYGADDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 907 MSTMPGLPTRPCFYDIDLDPETEQVNGL 934
>gb|AAH75779.1| Methylenetetrahydrofolate dehydrogenase (NADP+ dependent),
methenyltetrahydrofolate cyclohydrolase,
formyltetrahydrofolate synthetase [Danio rerio]
Length = 934
Score = 834 bits (2154), Expect = 0.0
Identities = 416/627 (66%), Positives = 491/627 (77%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L+++ PVPSD+ I+ S P I +A + L + +LYG+ KAKV L +D LQ DG
Sbjct: 309 LNLLRPVPSDVAISRSCVPKPIECLAKEIGLLSDEVELYGRTKAKVQLKTIDRLQTQLDG 368
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 369 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLKLNAFACVRQPSQGPTFGIKGGAAGGGY 428
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQV+PM+EFNLHLTGDIHAITAANNL+AAA+D R+FHE+TQSDKALFNRL P EG+R
Sbjct: 429 SQVVPMEEFNLHLTGDIHAITAANNLVAAAVDARMFHEATQSDKALFNRLVPL-AEGQRK 487
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FS V RL++ GI KT+P LT EE+ +F RLDIDP+S+TW+RV+D NDRFLRKIT+GQ
Sbjct: 488 FSPVQINRLERLGIKKTDPSTLTEEEITRFVRLDIDPESVTWQRVLDTNDRFLRKITIGQ 547
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDI+VASEIMAVLALTT L DM++RL KMV+ S+SG PVT +DLG+
Sbjct: 548 SPTEKGFTRTAQFDITVASEIMAVLALTTGLEDMKQRLAKMVVATSRSGQPVTTEDLGVC 607
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLM+DAI P LMQTLEG PV VHAGPFANIAHGNSSI+ADKIALKLVGP GFVVTE
Sbjct: 608 GALTVLMRDAIKPNLMQTLEGNPVFVHAGPFANIAHGNSSILADKIALKLVGPQGFVVTE 667
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL Y+ EN+
Sbjct: 668 AGFGADIGMEKFFNIKCRYSGLKPHVVVLVATVRALKMHGGGPTVTAGTPLPKEYIEENL 727
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
L+EAGCAN+ + + N+K +G V+VA+N F TDT AELN + K A +AGA+DAV CSH
Sbjct: 728 TLLEAGCANMRKQVENAKLFGVPVVVAVNAFKTDTQAELNLICKMAKEAGAFDAVPCSHW 787
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG GAVDL AVQ+A + +FLY + + I +KI IA K YGA +E +A++
Sbjct: 788 ADGGAGAVDLARAVQRAAD-LPNSFQFLYDVQLPIADKIRIIAQKIYGADDIELLPEAQQ 846
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K+E YTKQGF+ LPICMAKT S S +A KG PTGF+LPIRD+RAS+GAGF+YPLVGTM
Sbjct: 847 KVERYTKQGFADLPICMAKTHLSLSHDAEKKGVPTGFVLPIRDIRASVGAGFLYPLVGTM 906
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
T+PGLPTRPCFYDIDLDT +G+VIGL
Sbjct: 907 PTIPGLPTRPCFYDIDLDTESGEVIGL 933
>gb|AAH45396.1| Methylenetetrahydrofolate dehydrogenase (NADP+ dependent),
methenyltetrahydrofolate cyclohydrolase,
formyltetrahydrofolate synthetase [Danio rerio]
gi|41054762|ref|NP_955823.1| methylenetetrahydrofolate
dehydrogenase (NADP+ dependent),
methenyltetrahydrofolate cyclohydrolase,
formyltetrahydrofolate synthetase [Danio rerio]
Length = 934
Score = 829 bits (2141), Expect = 0.0
Identities = 414/627 (66%), Positives = 489/627 (77%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L+++ PVPSD+ I+ S P I +A + L + +LYG+ KAKV L +D LQ DG
Sbjct: 309 LNLLRPVPSDVAISRSCVPKPIECLAKEIGLLSDEVELYGRTKAKVQLKTIDRLQTQLDG 368
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 369 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLKLNAFACVRQPSQGPTFGIKGGAAGGGY 428
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQV+PM+EFNLHLTGDIHAITAANN +AAA+D R+FHE+TQSDKALFNRL P EG+R
Sbjct: 429 SQVVPMEEFNLHLTGDIHAITAANNPVAAAVDARMFHEATQSDKALFNRLVPL-AEGQRK 487
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FS V RL++ GI KT+P LT EE+ +F R DIDP+S+TW+RV+D NDRFLRKIT+GQ
Sbjct: 488 FSPVQINRLERLGIKKTDPSTLTEEEITRFVRPDIDPESVTWQRVLDTNDRFLRKITIGQ 547
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDI+VASEIMAVLALTT L DM++RL KMV+ S+SG PVT +DLG+
Sbjct: 548 SPTEKGFTRTAQFDITVASEIMAVLALTTGLEDMKQRLAKMVVATSRSGQPVTTEDLGVC 607
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLM+DAI P LMQTLEG PV VHAGPFANIAHGNSSI+ADKIALKLVGP GFVVTE
Sbjct: 608 GALTVLMRDAIKPNLMQTLEGNPVFVHAGPFANIAHGNSSILADKIALKLVGPQGFVVTE 667
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL Y+ EN+
Sbjct: 668 AGFGADIGMEKFFNIKCRYSGLKPHAVVLVATVRALKMHGGGPTVTAGTPLPKEYIEENL 727
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
L+EAGCAN+ + + N+K +G V+VA+N F TDT AELN + K A +AGA+DAV CSH
Sbjct: 728 TLLEAGCANMRKQVENAKLFGVPVVVAVNAFKTDTQAELNLICKMAKEAGAFDAVPCSHW 787
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG GAVDL AVQ+A + +FLY + + I +KI IA K YGA +E +A++
Sbjct: 788 ADGGAGAVDLARAVQRAAD-LPNSFQFLYDVQLPIADKIRIIAQKIYGADDIELLPEAQQ 846
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K+E YTKQGF+ LPICMAKT S S +A KG PTGF+LPIRD+RAS+GAGF+YPLVGTM
Sbjct: 847 KVERYTKQGFADLPICMAKTHLSLSHDAEKKGVPTGFVLPIRDIRASVGAGFLYPLVGTM 906
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
T+PGLPTRPCFYDIDLDT +G+VIGL
Sbjct: 907 PTIPGLPTRPCFYDIDLDTESGEVIGL 933
>pir||A35367 methylenetetrahydrofolate dehydrogenase (NADP) (EC 1.5.1.5) - rat
Length = 935
Score = 828 bits (2138), Expect = 0.0
Identities = 418/628 (66%), Positives = 494/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 309 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 488 KFSDIQIRRLRRLGIEKTDPAALTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMR RLGKMV+ +SK G+P++ +DLG+
Sbjct: 548 QAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRARLGKMVVASSKKGEPISCEDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP FVVT
Sbjct: 608 QGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPERFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTD EL+ + + + + GA+DAV C+H
Sbjct: 728 LDLVEKGFSNLRKQIENARMFGVPVVVAMNAFKTDTDTELDLIGRLSREHGAFDAVKCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 788 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSVEDKIRIIAQKIYGADDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPI MAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 NKAEIYTKQGFGNLPISMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV+GL
Sbjct: 907 MSTMPGLPTRPCFYDIDLDPETEQVMGL 934
>emb|CAG32567.1| hypothetical protein [Gallus gallus]
Length = 935
Score = 822 bits (2122), Expect = 0.0
Identities = 412/628 (65%), Positives = 497/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
+L + PVPSDI+I+ S P I ++A + L P+ +LYG+ KAKV LSAL L+ D
Sbjct: 309 QLTLKMPVPSDIEISRSCIPKPIDQVAKEIGLLPDEIELYGQTKAKVHLSALKRLKNQPD 368
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 369 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGG 428
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQV+PM+EFNLHLTGDIHAITAANNL+AAA+DTRIFHE TQSD+AL+NRL P + G R
Sbjct: 429 YSQVVPMEEFNLHLTGDIHAITAANNLVAAAVDTRIFHELTQSDQALYNRLVP-SVNGVR 487
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FS++ RRL+K GISKT+P LT EEVN F RLDIDP +ITW+RV+D NDRFLR+IT+G
Sbjct: 488 KFSEIQIRRLQKLGISKTDPAALTKEEVNLFVRLDIDPATITWQRVLDTNDRFLRRITIG 547
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDI+V+SEIMAVLAL+ L DM++RLG+MV+ +SK G+PVT DDLG+
Sbjct: 548 QSPTEKGFSRMAQFDITVSSEIMAVLALSDGLDDMKKRLGRMVVASSKRGEPVTTDDLGV 607
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GAL VLMKDA+ P LMQTLEGTPV VHAGPFANIAHGNSS++ADKIALKLVG GFVVT
Sbjct: 608 TGALAVLMKDAVKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGKEGFVVT 667
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYS L P ++VAT+RALKMHGGGPAV AG PL Y+ EN
Sbjct: 668 EAGFGADIGMEKFFNIKCRYSDLRPNVVVLVATVRALKMHGGGPAVTAGIPLPKEYMEEN 727
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ L+ GC+NL++ I N++ +G V+VA+N F TDT AEL V + A +AGA+DAV+C+H
Sbjct: 728 LQLLAKGCSNLSKQIQNARLFGVPVVVAVNAFKTDTKAELALVVQLAKEAGAFDAVVCTH 787
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAE 550
A GG+GAV L AVQ+A + + +FLY +++ + +KI IA+ YGAS +E +A+
Sbjct: 788 WAEGGKGAVALAQAVQRASQTPSN-FRFLYNVELPVIDKIRIIAQQIYGASDIELLPEAQ 846
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
+K+ +YTKQGF LPICMAKT S S + KGAPTGFILPIRD+RAS+GAGF+YPLVGT
Sbjct: 847 EKVAVYTKQGFGNLPICMAKTHLSLSHDPEQKGAPTGFILPIRDIRASVGAGFLYPLVGT 906
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRP FYDIDLDT +G+V GL
Sbjct: 907 MSTMPGLPTRPSFYDIDLDTASGEVNGL 934
>emb|CAG10709.1| unnamed protein product [Tetraodon nigroviridis]
Length = 909
Score = 816 bits (2109), Expect = 0.0
Identities = 412/628 (65%), Positives = 485/628 (76%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ PVPSDI I+ S P I A + L + +L+G KAKV L+ + LQ D
Sbjct: 283 KLNLQKPVPSDIVISRSCVPKPIDHFATEVGLLSDEVELFGTTKAKVRLNIIQRLQAQPD 342
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTTVGL QA+GA + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 343 GKYVVVTGITPTPLGEGKSTTTVGLVQAMGAHMKLNVFACVRQPSQGPTFGIKGGAAGGG 402
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAA+D R+FHESTQSDKAL+NRL P + G+R
Sbjct: 403 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAVDARMFHESTQSDKALYNRLVPLSG-GER 461
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FS + RL+K GI KT+P LT EEV +F+RLDIDP ++TW+RV+D NDRFLRKIT+G
Sbjct: 462 KFSPIQINRLRKLGIEKTDPSSLTEEEVTRFSRLDIDPSTVTWQRVLDTNDRFLRKITIG 521
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG RE FDI+VASEIMAVLALTTSL DMR+RL +MV+ S+SG P+T +DLG+
Sbjct: 522 QSPTEKGYTREAQFDITVASEIMAVLALTTSLEDMRQRLARMVVATSRSGQPITTEDLGV 581
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEG PV VHAGPFANIAHGNSSI+ADKIALKLVGP G+VVT
Sbjct: 582 SGALTVLMKDAIKPNLMQTLEGNPVFVHAGPFANIAHGNSSILADKIALKLVGPEGYVVT 641
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL Y+ EN
Sbjct: 642 EAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGMPLPKEYIDEN 701
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ L+E GC+N+ + I N++ +G V+VA+N F TDT+AEL V A AGA+DAV C+H
Sbjct: 702 LQLLEKGCSNMKKQIQNAQHFGVPVVVAVNAFKTDTEAELALVCSIAKAAGAFDAVRCTH 761
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG GAV LG AVQ+A E A +FLY L++ I +KI IA K YGA +E +A+
Sbjct: 762 WAEGGAGAVALGQAVQRASE-APSNFRFLYDLELPITDKIRTIAQKIYGADDIELLPEAQ 820
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
+K+E Y+KQGF LP+CMAKT S S A KG PTGF+LPIRD+RAS GAGF++PLVGT
Sbjct: 821 QKVERYSKQGFGSLPVCMAKTHLSLSHEADRKGVPTGFVLPIRDIRASAGAGFLFPLVGT 880
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
M T+PGLPTRPCFYDIDLD T QV GL
Sbjct: 881 MPTIPGLPTRPCFYDIDLDPETEQVNGL 908
Database: nr
Posted date: Jul 5, 2005 12:34 AM
Number of letters in database: 863,360,394
Number of sequences in database: 2,540,612
Lambda K H
0.318 0.136 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,094,053,543
Number of Sequences: 2540612
Number of extensions: 48261566
Number of successful extensions: 118058
Number of sequences better than 10.0: 671
Number of HSP's better than 10.0 without gapping: 665
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 114287
Number of HSP's gapped (non-prelim): 1124
length of query: 639
length of database: 863,360,394
effective HSP length: 134
effective length of query: 505
effective length of database: 522,918,386
effective search space: 264073784930
effective search space used: 264073784930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 78 (34.7 bits)
Medicago: description of AC146329.5