BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC140550.8 + phase: 0 /pseudo
(496 letters)
Database: nr
2,540,612 sequences; 863,360,394 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_176101.1| DNA-binding bromodomain-containing protein [Ara... 313 6e-84
ref|XP_507560.1| PREDICTED P0007D08.15 gene product [Oryza sativ... 236 1e-60
gb|AAC64610.1| Hypothetical protein F13C5.2 [Caenorhabditis eleg... 82 4e-14
ref|XP_655875.1| bromodomain protein, putative [Entamoeba histol... 82 4e-14
emb|CAG79786.1| unnamed protein product [Yarrowia lipolytica CLI... 82 5e-14
emb|CAF90901.1| unnamed protein product [Tetraodon nigroviridis] 82 5e-14
emb|CAH02064.1| unnamed protein product [Kluyveromyces lactis NR... 80 2e-13
gb|AAH76786.1| Brd4-prov protein [Xenopus laevis] 79 3e-13
ref|NP_524642.2| CG15319-PB [Drosophila melanogaster] gi|2283304... 79 4e-13
emb|CAE63646.1| Hypothetical protein CBG08144 [Caenorhabditis br... 79 4e-13
emb|CAA72780.1| HUNKI [Homo sapiens] gi|7657218|ref|NP_055114.1|... 78 7e-13
gb|AAH30158.1| BRD4 protein [Homo sapiens] 78 7e-13
gb|EAL89734.1| bdf1 protein [Aspergillus fumigatus Af293] 78 7e-13
ref|XP_343176.2| PREDICTED: similar to R31546_1 [Rattus norvegicus] 78 7e-13
gb|AAH82782.1| Brd4 protein [Mus musculus] 78 7e-13
gb|AAL67834.1| bromodomain-containing protein BRD4 short variant... 78 7e-13
gb|AAL67833.1| bromodomain-containing protein BRD4 long variant ... 78 7e-13
gb|AAO22237.1| BRD4-NUT fusion oncoprotein [Homo sapiens] 78 7e-13
gb|AAL26987.1| bromodomain-containing 4 [Homo sapiens] gi|197187... 78 7e-13
pir||T13828 CREB-binding protein homolog - fruit fly (Drosophila... 78 7e-13
>ref|NP_176101.1| DNA-binding bromodomain-containing protein [Arabidopsis thaliana]
gi|12321252|gb|AAG50696.1| hypothetical protein
[Arabidopsis thaliana] gi|25404180|pir||E96613
hypothetical protein T15M6.22 [imported] - Arabidopsis
thaliana
Length = 769
Score = 313 bits (803), Expect = 6e-84
Identities = 226/580 (38%), Positives = 290/580 (49%), Gaps = 115/580 (19%)
Query: 1 MKRKRGHKKGRPKGNTNPV-SVTLTNEQEEEEEEEEETSAFDVGSKEDNNSGMEVDTPS- 58
MKRKRGHKKG+ N ++ + E E + E + A + S MEVD PS
Sbjct: 1 MKRKRGHKKGKKSKTINEQGNLNESTENAENQTSEHSSEAPVECENSELESKMEVDAPSP 60
Query: 59 -STGTDQHSNLANINPDGSIRKPVGRVKVKLKTSKMLDSQPNSSDAPSQSDTDKSSQQQH 117
+ D N+A K V RVKVKLKTSK +PN + + D DKSS Q
Sbjct: 61 IAGSVDLADNIA--------AKSVARVKVKLKTSKA--PEPNET---LRDDIDKSSSQA- 106
Query: 118 GLERHGVNADRIEDSVTSFPDLK--YGASYKKAGSIKIKSSK------------------ 157
LE+ V ++ E+ V P+ K + Y+K I+IKSSK
Sbjct: 107 VLEKPVVPVEKKEEFVPRLPERKPVFLNVYRKTKGIRIKSSKAVDGSSSVTEKSATDTVK 166
Query: 158 ----VLGLNADQTSKPLPISSE-------IIHPKERKMPPLNPRYNKHELDTSLMIIRKV 206
V+G +TS+ +S+ I KE K N RYNK EL+ SL++I+K+
Sbjct: 167 VQDVVVGQKDTKTSEENSQASKKEAEIATISLQKEEKKTDQNLRYNKQELEDSLIVIKKI 226
Query: 207 MKMDAAEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIW 266
MKM+AA+PFNVPVNPEALGIPDYFDII TPMDFGTIC+N EK +KYMNSEDVY DV YIW
Sbjct: 227 MKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKGNKYMNSEDVYKDVNYIW 286
Query: 267 ENCYKYNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP---------KGSTDFK------ 311
NC KYN KGDYIVDLMKRVKKNFMKYW +AGLY+EQ K ST K
Sbjct: 287 NNCSKYNKKGDYIVDLMKRVKKNFMKYWTSAGLYTEQSAAENTEDGGKASTKQKSHKRHG 346
Query: 312 ---------------------------QEESMLVESPGGEDSLSNTDELLGTDGDVDDDK 344
QEES SP G S+ N+ +G D D+D DK
Sbjct: 347 RHHKSDCMCAICVLKRRKRERERDSGAQEES----SPAGSPSVDNSSVNMGEDMDIDVDK 402
Query: 345 GEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEEN--HGPEDVEEDEEEDGEGENEE---- 398
P + E+ E+D + + ++VEE+E + E EN+
Sbjct: 403 -------------KPEQEKTEIVELDSPVSKTQRVIENKQEVEEEENVEVESENKTKANV 449
Query: 399 EIEMNRVKRRMDETLRHGGTLAEESEVGDTAALHDEYKNTQQEGQAAVVQQQKKHKEPQD 458
E + + R M+ET A E V + + ++E + +Q+QKK E +
Sbjct: 450 EDKTQSIDRSMEETGDEPVNSAAEKLVVLASLEGPKSTQNEEEEKEKRLQEQKKRLELER 509
Query: 459 KHQKAKLLESLCSENPMLSSLCGTLFP--KNSQSVWSGPH 496
K + K+ E NP L SLC TLFP N SVW+GPH
Sbjct: 510 KEWRMKMQEKFQVRNPQLLSLCETLFPNDNNHNSVWNGPH 549
>ref|XP_507560.1| PREDICTED P0007D08.15 gene product [Oryza sativa (japonica
cultivar-group)] gi|50940389|ref|XP_479722.1|
DNA-binding protein family-like [Oryza sativa (japonica
cultivar-group)] gi|51964614|ref|XP_507091.1| PREDICTED
P0007D08.15 gene product [Oryza sativa (japonica
cultivar-group)] gi|42408376|dbj|BAD09527.1| DNA-binding
protein family-like [Oryza sativa (japonica
cultivar-group)]
Length = 590
Score = 236 bits (602), Expect = 1e-60
Identities = 184/575 (32%), Positives = 262/575 (45%), Gaps = 91/575 (15%)
Query: 1 MKRKRGHKKGR-------------PKGNTNPVSVTLTNEQEEEEEEEEETSAFDVGSKED 47
MKRKRG K G+ P ++P +V +++ EE ++ +
Sbjct: 1 MKRKRGRKMGKKGKLKASITADASPMSPSSPSTVDASSKSPSSPSTEENGTS--PAHHQA 58
Query: 48 NNSGMEVDTPSSTGTDQHSNLANINPDGSIRKP--VGRVKVKLKTSKMLDSQPNSSDAPS 105
+N+ + P ++ D KP RV++K K++K+L++ S+A +
Sbjct: 59 DNAPVIAPPPVPEPAPPEPEKPAVSTDVQNAKPKVYSRVRLKFKSAKVLETHQGPSEAKA 118
Query: 106 QSD-------TDKSSQQQHGLERHGVNADRIEDS-VTSFPDLKYGASYKKAGSIKIKS-- 155
D + + E+ V+ D +D+ +K SI IKS
Sbjct: 119 PVDGGGGKPASAAPEASKEVAEKAIVSPDGQKDAQAAELSGSDKDKMARKVASINIKSVG 178
Query: 156 -----SKVLGLNADQTSKPLPISSEIIHPKERKMPPLNPRYNKH---------------E 195
K AD S+PLP E + L PR ++ E
Sbjct: 179 LSSVEDKNQDRKADSVSEPLPSKQETVLENVESETALEPRSSQELEVKQATPERQRDDRE 238
Query: 196 LDTSLMIIRKVMKMDAAEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNS 255
L +L I+KVMKMDAAEPFN PV+P ALGIPDYFDIIDTPMDFGTIC NLE+ DKYMNS
Sbjct: 239 LTAALEAIKKVMKMDAAEPFNTPVDPVALGIPDYFDIIDTPMDFGTICQNLERGDKYMNS 298
Query: 256 EDVYNDVRYIWENCYKYNNKGDYIVDLMKRVKKNFMKYWAAAGLYSE-QPKGSTDFKQEE 314
EDVY DV++IW+NC KYN+KGDYI++LMKRVKK FMK W AAGLYS+ Q G D +E
Sbjct: 299 EDVYKDVQFIWDNCTKYNSKGDYIIELMKRVKKGFMKNWLAAGLYSDAQENGGNDNTGDE 358
Query: 315 SMLVESPGGEDSLSNTDELLGTDGDVDD-------------DKGE---VTKMETSEKNCS 358
+ G + LG D +D +K E V + +T+ N +
Sbjct: 359 DV----KGSKGKSKQKRRRLGNDRHKNDCACAVCQVTRRKKEKDEILAVIENDTAAVNSN 414
Query: 359 PSDGRHEVNEVDDDGMEEENHGPEDVEEDEEEDGE---------GENEEEIEMNRVKRRM 409
SD ++ EVD N G D +E+ + ++ + N VK
Sbjct: 415 ISD--QQIMEVDSG---INNAGSHDTTSSQEQPPQTDMYRRTVVADDSGTLIENHVKFFN 469
Query: 410 DETLRHG-------GTLAEESEVGDTAALHDEYKNTQQEGQAAVVQQQKKHKEPQDKHQK 462
++ L H E+ EV T + E + Q + + Q +HKEP + Q+
Sbjct: 470 NQPLPHDYEDEGSRPYFDEKEEVDYTDLISQEEHTSSQPNDGSEIAQH-QHKEPTETSQE 528
Query: 463 AKLLE-SLCSENPMLSSLCGTLFPKNSQSVWSGPH 496
++ + + EN LC LFP N SV+ G H
Sbjct: 529 IEMEDYPIQKENQSFLQLCARLFPSNQSSVFRGRH 563
>gb|AAC64610.1| Hypothetical protein F13C5.2 [Caenorhabditis elegans]
gi|7498991|pir||T33328 hypothetical protein F13C5.2 -
Caenorhabditis elegans gi|17551634|ref|NP_508124.1|
kinase (40.9 kD) (XB213) [Caenorhabditis elegans]
Length = 374
Score = 82.0 bits (201), Expect = 4e-14
Identities = 58/228 (25%), Positives = 104/228 (45%), Gaps = 25/228 (10%)
Query: 214 PFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYN 273
PF PV+ LG+ DY ++I PMD TI L ++Y + + D + + NC YN
Sbjct: 140 PFRKPVDVVLLGLTDYHEVIKKPMDMSTIRKKLI-GEEYDTAVEFKEDFKLMINNCLTYN 198
Query: 274 NKGDYIVDLMKRVKKNFMKYWAAAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSNTDEL 333
N+GD + D + +K F W E P+ F QE+ E
Sbjct: 199 NEGDPVADFALQFRKKFAAKWK-----KEFPEDGDSFGQEKG----------------EK 237
Query: 334 LGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEEEDGE 393
G+D + D+++ + + E K + + E E D+ EEE+H ED E++EE+
Sbjct: 238 EGSDNEDDEEEVDEKEKEEEVKEDNAEEKPAEEPEQPDE-KEEEDH--EDEREEQEEEDS 294
Query: 394 GENEEEIEMNRVKRRMDETLRHGGTLAEESEVGDTAALHDEYKNTQQE 441
+ E+ ++ + V+R + + E+ + + AA H ++++ +
Sbjct: 295 SDEEDGLDDDDVRRHIPASTSAPVAKHPEAAMPEPAAEHSSIQSSEAQ 342
Score = 34.3 bits (77), Expect = 9.3
Identities = 30/125 (24%), Positives = 49/125 (39%), Gaps = 14/125 (11%)
Query: 359 PSDGRHEVNEVDDDGMEEENHGPEDVEEDEEEDGEGENEEEIEMNRVKRRMDETLRHGGT 418
P DG D G E+ D E+DEEE E E EEE++ + + + E
Sbjct: 224 PEDG-------DSFGQEKGEKEGSDNEDDEEEVDEKEKEEEVKEDNAEEKPAEEPEQPDE 276
Query: 419 LAEESEVGDTAALHDEYKNTQQEGQAAVVQQQKKH-----KEPQDKHQKAKLLESLCSEN 473
EE + +E + +++G ++H P KH +A + E +
Sbjct: 277 KEEEDHEDEREEQEEEDSSDEEDGLDD--DDVRRHIPASTSAPVAKHPEAAMPEPAAEHS 334
Query: 474 PMLSS 478
+ SS
Sbjct: 335 SIQSS 339
>ref|XP_655875.1| bromodomain protein, putative [Entamoeba histolytica HM-1:IMSS]
gi|56473058|gb|EAL50506.1| bromodomain protein, putative
[Entamoeba histolytica HM-1:IMSS]
Length = 265
Score = 82.0 bits (201), Expect = 4e-14
Identities = 45/149 (30%), Positives = 79/149 (52%), Gaps = 2/149 (1%)
Query: 146 KKAGSIKIKSSKVLGLNADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRK 205
+K G K + K + + +P+ S +E+ + P N E + + ++++
Sbjct: 17 EKKGQKKEREKKESKIEEGSSHRPMTRSMSGYEIEEKPVIKNEP-LNSFEKELCMSVMKQ 75
Query: 206 VMKMDAAEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYI 265
+MK+ +E F PV+PE IP+YFDII TPMD GT+ ++KN Y + ++ NDVR
Sbjct: 76 LMKVSESEVFMEPVDPEIWNIPNYFDIIKTPMDLGTVIKKIKKN-MYYSIDEFSNDVRLT 134
Query: 266 WENCYKYNNKGDYIVDLMKRVKKNFMKYW 294
+ N +N G+Y+ +++ K F Y+
Sbjct: 135 FTNAMTFNPPGNYVHSYAEKLYKIFENYY 163
>emb|CAG79786.1| unnamed protein product [Yarrowia lipolytica CLIB99]
gi|50553560|ref|XP_504191.1| hypothetical protein
[Yarrowia lipolytica]
Length = 653
Score = 81.6 bits (200), Expect = 5e-14
Identities = 82/337 (24%), Positives = 141/337 (41%), Gaps = 45/337 (13%)
Query: 175 EIIHPKERKMPPLN--PRYNKHELDTSL--MIIRKVMKMDAAE---PFNVPVNPEALGIP 227
EI PK + +P N PR KH ++ +++++ E PF +PV+P AL P
Sbjct: 286 EIHPPKPKDLPYTNIKPRKKKHAIELRFCNQVLKELTSKKHEEYSFPFLLPVDPVALNCP 345
Query: 228 DYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRVK 287
YF II PMD T+ + N+ Y +++ +DVR I++NCY++N G + + KR++
Sbjct: 346 SYFKIIKEPMDLSTVQEKMN-NNAYETADEFESDVRLIFKNCYRFNPDGTPVNKMGKRLE 404
Query: 288 KNFMKYWAAAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSN--TDELLGTDGDVDDDKG 345
F K WA + P + D + S E ED S+ + + ++ K
Sbjct: 405 AIFDKKWAEKPIPPPSPPPTMD---DSSDYDEYSSDEDLASSITNPAIAFLEEQIERMKQ 461
Query: 346 EVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEEEDGEG-----ENEEEI 400
E+TKM+ D E+ G + + + D G E ++E+
Sbjct: 462 ELTKMK--------KDAAREMKRSRRRGSSKRSKSSSKRKGSRSSDSGGVVVSYEMKKEL 513
Query: 401 EMNRVKRRMDETLRHGGTLAEESEVGDTAALHDEYKNTQQEGQAAVVQQQKKHKEPQDKH 460
R+ + ++ L+H L +H+ + EGQ + + + D H
Sbjct: 514 S-ERIPQLKEKQLQHVINL-----------IHESMPQLKSEGQDEI----ELDMDQLDPH 557
Query: 461 QKAKLLESLCSENPMLSSLCG---TLFPKNSQSVWSG 494
KL + ++ S G T + S SV+ G
Sbjct: 558 TLMKLYNYVVKDDSKKKSSSGGKSTSSSRPSSSVYPG 594
Score = 69.3 bits (168), Expect = 3e-10
Identities = 55/222 (24%), Positives = 102/222 (45%), Gaps = 15/222 (6%)
Query: 74 DGSIRKPVGRV-KVKLKTSKMLDSQPNSSDAPSQSDTDKSSQQQHGLERHGVNADRIEDS 132
D +++P V K +K ++ D+ ++ P +D+ +++ + A + ++S
Sbjct: 14 DVDVKRPGDDVEKDDIKRPRVEDTDAMDTEEPKPTDSKDATESKPD------EAPKSDES 67
Query: 133 VTSFPDLKYGASYK-KAGSIKIKSSKVLGLNADQTSKPLPISSEIIHPKERKMPPLNPRY 191
D K K + + K + +++ S P P SS + K P
Sbjct: 68 EVKDSDDKPTEETKPEVKTEDTKGQQDESAHSEAASLPTPSSSIVESDKPVVEMP----- 122
Query: 192 NKHELDTSLMIIRKVMKMDAAEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDK 251
KH++ + ++ V ++ A PF PV+P L IP YF++I PMD GT+ L N +
Sbjct: 123 -KHQVKYAASSLKAVKRLKDAAPFIHPVDPVKLNIPTYFEVIKHPMDLGTMEKKL-NNGE 180
Query: 252 YMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRVKKNFMKY 293
Y ED+ DV+ I +NC +N +I + K + +F ++
Sbjct: 181 YGTKEDMIADVQRIVDNCLTFNGADSFISSMAKSLFTSFERH 222
>emb|CAF90901.1| unnamed protein product [Tetraodon nigroviridis]
Length = 1594
Score = 81.6 bits (200), Expect = 5e-14
Identities = 59/178 (33%), Positives = 89/178 (49%), Gaps = 18/178 (10%)
Query: 160 GLNADQTSKPLP-ISSEIIHPKER---KMPPLNPRYNKHELDTSLM-IIRKVMKMDAAEP 214
G A +P P +S+ H K R K PL P+ ++L L +++ + K A P
Sbjct: 420 GRKAGGKQQPEPSLSTSSSHRKTRHPLKYGPLQPKRQTNQLQYLLKEVLKSLWKHHFAWP 479
Query: 215 FNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNN 274
F PV+ L +PDY+ II TPMD GTI LE N+ Y N+++ +D ++ NCY YN
Sbjct: 480 FQAPVDAVKLNLPDYYKIIKTPMDMGTIKRRLE-NNYYWNAQECIHDFNTMFTNCYIYNK 538
Query: 275 KGDYIVDLMKRVKKNFMKYWAAAGLYSEQ----PKGSTDFKQEESMLVESPGGEDSLS 328
GD IV + + ++K F++ ++ PKG ++E GEDS S
Sbjct: 539 PGDDIVLMAEALEKVFLQKITEMPQEEKEIAVVPKGRRGVRRE--------SGEDSSS 588
Score = 63.5 bits (153), Expect = 1e-08
Identities = 60/250 (24%), Positives = 99/250 (39%), Gaps = 45/250 (18%)
Query: 143 ASYKKAGSIKIKSSKVLGLNADQTSKPLPISSEII----------HPKERKMPPLNPRY- 191
A K S K K+ DQ S+ P+S+E PK + P + Y
Sbjct: 668 ALIKHRKSQKRKADTTTPTANDQLSESSPVSAEAQPQREPSRVSKQPKREALQPDSQHYL 727
Query: 192 -------------NKHELDTSLMIIRKVMKMDAAE---PFNVPVNPEALGIPDYFDIIDT 235
+ +L ++R+++ A PF PV+ +LG+ DY+DII
Sbjct: 728 GGGLESGGTLPPKRQEQLRFCARLVREMLSRKHASYAWPFYKPVDVTSLGLHDYYDIIKH 787
Query: 236 PMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRVKKNFMKYWA 295
PMD TI ++ +Y ++++ DVR ++ NCYKYN +V + + ++ F +A
Sbjct: 788 PMDLSTIKKKMDSR-QYRDAQEFAADVRLMFSNCYKYNPPDHDVVSMARNLQDVFEMRFA 846
Query: 296 AAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSNTDELLGTDGDVDDDKGEVTKMETSEK 355
+ P+ + S L+ +P V DD +SE
Sbjct: 847 K---MPDDPEEAVPVPTPSSALLPAPSTRQV---------PPPAVSDDSS-----SSSES 889
Query: 356 NCSPSDGRHE 365
CS +D E
Sbjct: 890 ECSSADSEKE 899
>emb|CAH02064.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
gi|50303459|ref|XP_451671.1| unnamed protein product
[Kluyveromyces lactis]
Length = 661
Score = 79.7 bits (195), Expect = 2e-13
Identities = 46/164 (28%), Positives = 81/164 (49%), Gaps = 9/164 (5%)
Query: 175 EIIHPKERKMPPLN---PRYNKHELDTSL--MIIRKVMKMDAAE---PFNVPVNPEALGI 226
EI PK + + P P+ KH+++ ++++++ + PF PV+P AL
Sbjct: 256 EIHPPKTKDIYPYESNKPKSKKHQMEMKFCQQVLKELLSKKYSSFNYPFLEPVDPVALNC 315
Query: 227 PDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRV 286
P YFD + PMD GT+ L N +Y SE+ +DVR +++NCY +N +G + + R+
Sbjct: 316 PTYFDFVKEPMDLGTVQKKLN-NWEYQTSEEFEHDVRLVFKNCYAFNPEGTIVNMMGHRL 374
Query: 287 KKNFMKYWAAAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSNT 330
+ F WA + E+ + E+ + P E+ + T
Sbjct: 375 EDVFNSKWADRPVIPEEESADEGGESEDGYESDEPSEEEQIDET 418
Score = 67.8 bits (164), Expect = 8e-10
Identities = 66/295 (22%), Positives = 108/295 (36%), Gaps = 62/295 (21%)
Query: 32 EEEEETSAFDVGSKEDNNSGMEVDTPSSTGTDQHSNLANINPDGSIRKPVGRVKVKLKTS 91
+E ET FD + + G S G G V +
Sbjct: 10 KEAHETGIFDTKPVDAKSEGQAQPEAESDGASNG----------------GAAVVATPAA 53
Query: 92 KMLDSQPNSSDAPSQSDTDKSSQQQHGLERHGVNADRIEDSVTSFPDLKYGASYKKAGSI 151
++ + + S P+ S T++ +Q+H L+ AD +
Sbjct: 54 TPVEGEADESIDPAASATEQEQEQKHELKDESAAADTPK--------------------- 92
Query: 152 KIKSSKVLGLNADQTSKPLPISSEIIHPKERKMP--PLNPRYNKHELDTSLMIIRKVMKM 209
+D P P P +P PL P KH ++ ++ V ++
Sbjct: 93 -----------SDMVPAPAPPQE----PDMNNLPQNPLPPHQKKH----AVTAVKAVKRL 133
Query: 210 DAAEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENC 269
A+PF+ PV+P AL IP YF+ I PMD TI L D Y E V +D + NC
Sbjct: 134 KDAKPFHKPVDPVALNIPLYFNYIPRPMDLSTIERKLNL-DAYETPEQVTDDFNLMVSNC 192
Query: 270 YKYNNKGDYIVDLMKRVKKNFMKY---WAAAGLYSEQPKGSTDFKQEESMLVESP 321
K+N I + + ++ +F K+ A +QPK + + ++ +P
Sbjct: 193 IKFNGDKAVISQMARNIQASFEKHMLNMPAKDAPPQQPKRTKTHPDQPVVIRRAP 247
>gb|AAH76786.1| Brd4-prov protein [Xenopus laevis]
Length = 1362
Score = 79.0 bits (193), Expect = 3e-13
Identities = 50/146 (34%), Positives = 75/146 (51%), Gaps = 8/146 (5%)
Query: 165 QTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVNPEA 223
Q ++P P + + P P P+ ++L L + K + K A PF VPV+
Sbjct: 31 QPAQPQPQTPMMQTPPPEIARPNQPKRQTNQLQYLLKTVLKTLWKHQFAWPFQVPVDVVK 90
Query: 224 LGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLM 283
L +PDY+ II TPMD GTI LE N Y N+++ D ++ NCY YN GD IV +
Sbjct: 91 LNLPDYYKIIKTPMDMGTIKKRLE-NHFYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMA 149
Query: 284 KRVKKNFMKYWAAAGLYSEQPKGSTD 309
+ ++K F++ SE P+ T+
Sbjct: 150 EALEKLFLQ------KISEMPQEETE 169
Score = 66.6 bits (161), Expect = 2e-09
Identities = 53/200 (26%), Positives = 93/200 (46%), Gaps = 14/200 (7%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ E LG+ DY +II PMD GTI +E D Y N++D +DVR ++ NCYK
Sbjct: 390 AWPFYKPVDVETLGLHDYCEIIKHPMDLGTIKVKMENCD-YKNAQDFASDVRLMFSNCYK 448
Query: 272 YNNKGDYIVDLMKRVKKNF-MKYWAAAGLYSEQP---KGSTDFKQEESMLVESPGGEDSL 327
YN +V + ++++ F M++ E P S+ + P D+
Sbjct: 449 YNPPDHEVVIMARKLQDVFEMRFAKMPDEPEEAPAPVPSPAPGPPAPSIKIPPPTSSDTS 508
Query: 328 SNTDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEED 387
S D D + ++ E +++ + V+E + + + P+ E +
Sbjct: 509 S--------DSSSDSESSSDSEEERAQRLAELQEQLKAVHEQLAALSQPQPNKPKKKERE 560
Query: 388 EEEDGEGENEEEIEMNRVKR 407
+ ++ + + +EE+E R R
Sbjct: 561 KRKE-KHKRKEEVEETRKGR 579
>ref|NP_524642.2| CG15319-PB [Drosophila melanogaster] gi|22833041|gb|AAF46516.2|
CG15319-PB [Drosophila melanogaster]
Length = 3276
Score = 78.6 bits (192), Expect = 4e-13
Identities = 69/266 (25%), Positives = 121/266 (44%), Gaps = 31/266 (11%)
Query: 14 GNTNPVSVTLTNEQEEEEEEEEETSAFDVGSKEDNNSGMEVDTPSSTGTDQHSNLANINP 73
G+ N + + + +++++ F S NN ++D + G + N+N
Sbjct: 1544 GSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGK-----NVNN 1598
Query: 74 DGSIRKPVGRVKVKLKTSKMLDSQPNSSDAPSQSDTDKSSQ--QQHGLERHGVNADRIED 131
DG+ +K+++KT LD + D S + HG G +D
Sbjct: 1599 DGT-----SMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKD 1653
Query: 132 SVTSFPDLKYGASYKKAGSIKIKSSKVLGLNADQTSKPLPISSEIIHPKERKMPPLNPRY 191
++ D G + A IK K+ +KPL + ++K ++
Sbjct: 1654 NINGAHD---GGATGGAVDIKPKTE----------TKPLVPEPLAPNAGDKKK---KCQF 1697
Query: 192 NKHELDTSLM-IIRKVMKMDAAE-PFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKN 249
N EL T+L+ + K+ + + PF PV+P+ALGIPDYF+I+ PMD GTI +N++ N
Sbjct: 1698 NPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQ-N 1756
Query: 250 DKYMNSEDVYNDVRYIWENCYKYNNK 275
KY + + +DV +++N + YN K
Sbjct: 1757 GKYSDPWEYVDDVWLMFDNAWLYNRK 1782
>emb|CAE63646.1| Hypothetical protein CBG08144 [Caenorhabditis briggsae]
Length = 414
Score = 78.6 bits (192), Expect = 4e-13
Identities = 65/256 (25%), Positives = 106/256 (41%), Gaps = 26/256 (10%)
Query: 214 PFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYN 273
PF PV+ ALG+ DY +II PMD T+ + ++Y N+ + D + + NC YN
Sbjct: 144 PFRTPVDTVALGLTDYHEIIKKPMDMSTMKKKI-VGEEYDNAGEFKEDFKLMINNCLSYN 202
Query: 274 NKGDYIVDLMKRVKKNFMKYWAAAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSNTDEL 333
N GD + D+ + +K F W + F E+ G ++ + +
Sbjct: 203 NDGDPVSDMAIKFRKAFAAKW------------NKVFPDEKDNFAGEEGSDNGSGDEADQ 250
Query: 334 LGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEEEDGE 393
+ +DG+ D +K E K+ + P + V + DD + ED DEE +
Sbjct: 251 VESDGE-DAEKDESVKVTETANTEKPGEA---VAKTGDDSADRRRDAEEDESSDEE---D 303
Query: 394 GENEEEIEMNRVKRRMDETLRHGGTLAEESEVGDTAA-LHDEYKNTQQEGQAAVVQQQKK 452
G +EEE T T+AE+ AA + + E QA + Q
Sbjct: 304 GLDEEEATATSTSAATTAT-----TVAEKKASPTPAAQVATSSEPVVAEAQATSSEAQAT 358
Query: 453 HKEPQDKHQKAKLLES 468
E QD +A+ + +
Sbjct: 359 SFEVQDTSSEAQAVNN 374
>emb|CAA72780.1| HUNKI [Homo sapiens] gi|7657218|ref|NP_055114.1|
bromodomain-containing protein 4 isoform short [Homo
sapiens]
Length = 722
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 74.7 bits (182), Expect = 6e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 373 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE-YRDAQEFGADVRLMFSNCYK 431
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 432 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSD--SS 489
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 490 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 544
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 545 EKKKEKHKRKEEVEENK 561
>gb|AAH30158.1| BRD4 protein [Homo sapiens]
Length = 548
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 70.9 bits (172), Expect = 9e-11
Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 5/137 (3%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 373 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE-YRDAQEFGADVRLMFSNCYK 431
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 432 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSD--SS 489
Query: 330 TDELLGTDGDVDDDKGE 346
+D +D DD + E
Sbjct: 490 SDSSSDSDSSTDDSEEE 506
>gb|EAL89734.1| bdf1 protein [Aspergillus fumigatus Af293]
Length = 832
Score = 77.8 bits (190), Expect = 7e-13
Identities = 53/164 (32%), Positives = 79/164 (47%), Gaps = 7/164 (4%)
Query: 177 IHPKERKMP-PLNPRYNKHELDTS-----LMIIRKVMKMDAAEPFNVPVNPEALGIPDYF 230
IHP +R +P P+ K++ + L + K + A PF PV+P AL IP Y
Sbjct: 456 IHPPKRDLPYSTKPKKKKYQWELRFCQEVLDELHKPKHYNWAAPFYFPVDPVALNIPTYH 515
Query: 231 DIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRVKKNF 290
II PMD T+ S L K +Y N+++ D+R I++NC+K+N GD +R ++ F
Sbjct: 516 SIIKKPMDLSTVQSKL-KTGQYENAKEFEVDMRQIFKNCFKFNIPGDPTYMAGQRFQEIF 574
Query: 291 MKYWAAAGLYSEQPKGSTDFKQEESMLVESPGGEDSLSNTDELL 334
WA Y E + + + S ES ED +E L
Sbjct: 575 ENKWAQKTRYLEAHEPHPEHQSVSSSSEESEEEEDESDTDNEKL 618
Score = 57.8 bits (138), Expect = 8e-07
Identities = 72/305 (23%), Positives = 110/305 (35%), Gaps = 30/305 (9%)
Query: 12 PKGNTNPVSVTL---TNEQEEEEEEEEETSAFDVGSKEDNNSGMEVDTP------SSTGT 62
PK T P V T ++EEE+ ++ D KE + D P S+ GT
Sbjct: 82 PKSPTEPADVPAPSGTTATQKEEEKPLTSTPADGSDKEPKLENLIPDAPVTQETGSTVGT 141
Query: 63 DQHSNLANINPDGSIRKPVGRVKVKLKTSKMLDSQPNSSDAPSQSDTDKSSQQQHGLERH 122
DQ S + + KP K + ++ P T G +
Sbjct: 142 DQASP-QDTKASQDVSKPPTDSSSDAKVENNVQDSGVKTELPHHPSTSTKLDTMPG-DNP 199
Query: 123 GVNADRIEDSVTSFPDLKYGASYKKAGSIKIKSSKVLGLNADQTSKPLPISSEIIHPKER 182
NA + TS D+ A K S+ +AD P E E
Sbjct: 200 TSNAPTVPSLQTSDQDMPDAPD---APMSPTKVSRERDADADDEPAPKRTKLEDEGSAEV 256
Query: 183 KMPPLNPRYNKHELDTS---------------LMIIRKVMKMDAAEPFNVPVNPEALGIP 227
K+P L + T+ L I+ + +M+ A + PV+P + IP
Sbjct: 257 KLPDLPTPVTETPARTTVNGEATMTKVQHKFVLKGIQSLKRMNDARFYREPVDPIKMNIP 316
Query: 228 DYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIVDLMKRVK 287
Y II PMD GTI L KN++Y ++ V +D + +N +N + ++K
Sbjct: 317 HYPQIIKHPMDLGTIERKL-KNNEYKTAQAVVDDFNLMVQNAVTFNGPDHLVSQEGLKLK 375
Query: 288 KNFMK 292
F K
Sbjct: 376 GTFEK 380
>ref|XP_343176.2| PREDICTED: similar to R31546_1 [Rattus norvegicus]
Length = 1440
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 125 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 174
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 175 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 233
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 234 LMAEALEKLFLQ 245
Score = 75.9 bits (185), Expect = 3e-12
Identities = 56/198 (28%), Positives = 100/198 (50%), Gaps = 10/198 (5%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 460 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLESRE-YRDAQEFGADVRLMFSNCYK 518
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 519 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSD--SS 576
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 577 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 631
Query: 390 EDGEGENEEEIEMNRVKR 407
E + +++++ EM K+
Sbjct: 632 EKKKEKHKKKEEMEENKK 649
>gb|AAH82782.1| Brd4 protein [Mus musculus]
Length = 582
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 75.1 bits (183), Expect = 5e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 374 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLESRE-YRDAQEFGADVRLMFSNCYK 432
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 433 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSD--SS 490
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 491 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 545
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 546 EKKKEKHKKKEEVEENK 562
>gb|AAL67834.1| bromodomain-containing protein BRD4 short variant [Mus musculus]
gi|37674287|ref|NP_932762.1| bromodomain containing 4
isoform 2 [Mus musculus]
Length = 723
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 75.1 bits (183), Expect = 5e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 374 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLESRE-YRDAQEFGADVRLMFSNCYK 432
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 433 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSD--SS 490
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 491 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 545
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 546 EKKKEKHKKKEEVEENK 562
>gb|AAL67833.1| bromodomain-containing protein BRD4 long variant [Mus musculus]
gi|31560788|ref|NP_065254.2| bromodomain containing 4
isoform 1 [Mus musculus]
Length = 1400
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 75.1 bits (183), Expect = 5e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 374 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLESRE-YRDAQEFGADVRLMFSNCYK 432
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 433 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSD--SS 490
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 491 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 545
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 546 EKKKEKHKKKEEVEENK 562
>gb|AAO22237.1| BRD4-NUT fusion oncoprotein [Homo sapiens]
Length = 1846
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 74.7 bits (182), Expect = 6e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 373 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE-YRDAQEFGADVRLMFSNCYK 431
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 432 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSD--SS 489
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 490 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 544
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 545 EKKKEKHKRKEEVEENK 561
>gb|AAL26987.1| bromodomain-containing 4 [Homo sapiens]
gi|19718731|ref|NP_490597.1| bromodomain-containing
protein 4 isoform long [Homo sapiens]
gi|20141192|sp|O60885|BRD4_HUMAN Bromodomain-containing
protein 4 (HUNK1 protein)
Length = 1362
Score = 77.8 bits (190), Expect = 7e-13
Identities = 47/132 (35%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 162 NADQTSKPLPISSEIIHPKERKMPPLNPRYNKHELDTSLMIIRKVM-KMDAAEPFNVPVN 220
NA T+ P P +S P P+ ++L L ++ K + K A PF PV+
Sbjct: 39 NAASTNPPPPETSN----------PNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVD 88
Query: 221 PEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYKYNNKGDYIV 280
L +PDY+ II TPMD GTI LE N+ Y N+++ D ++ NCY YN GD IV
Sbjct: 89 AVKLNLPDYYKIIKTPMDMGTIKKRLE-NNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV 147
Query: 281 DLMKRVKKNFMK 292
+ + ++K F++
Sbjct: 148 LMAEALEKLFLQ 159
Score = 74.7 bits (182), Expect = 6e-12
Identities = 57/197 (28%), Positives = 100/197 (49%), Gaps = 12/197 (6%)
Query: 212 AEPFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKNDKYMNSEDVYNDVRYIWENCYK 271
A PF PV+ EALG+ DY DII PMD TI S LE + Y ++++ DVR ++ NCYK
Sbjct: 373 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE-YRDAQEFGADVRLMFSNCYK 431
Query: 272 YNNKGDYIVDLMKRVKKNFMKYWAAAGLYSEQP--KGSTDFKQEESMLVESPGGEDSLSN 329
YN +V + ++++ F +A E+P S+ + +V P D S+
Sbjct: 432 YNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSD--SS 489
Query: 330 TDELLGTDGDVDDDKGEVTKMETSEKNCSPSDGRHEVNEVDDDGMEEENHGPEDVEEDEE 389
+D +D DD ++ E +++ + V+E + + + P+ E+D++
Sbjct: 490 SDSSSDSDSSTDD-----SEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 544
Query: 390 EDGEGEN--EEEIEMNR 404
E + ++ +EE+E N+
Sbjct: 545 EKKKEKHKRKEEVEENK 561
>pir||T13828 CREB-binding protein homolog - fruit fly (Drosophila melanogaster)
gi|1916930|gb|AAB53050.1| CREB-binding protein homolog
[Drosophila melanogaster]
Length = 3190
Score = 77.8 bits (190), Expect = 7e-13
Identities = 69/266 (25%), Positives = 121/266 (44%), Gaps = 31/266 (11%)
Query: 14 GNTNPVSVTLTNEQEEEEEEEEETSAFDVGSKEDNNSGMEVDTPSSTGTDQHSNLANINP 73
G+ N + + + +++++ F S NN ++D + G + N+N
Sbjct: 1544 GSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGK-----NVNN 1598
Query: 74 DGSIRKPVGRVKVKLKTSKMLDSQPNSSDAPSQSDTDKSSQ--QQHGLERHGVNADRIED 131
DG+ +K+++KT LD + D S + HG G +D
Sbjct: 1599 DGT-----SMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKD 1653
Query: 132 SVTSFPDLKYGASYKKAGSIKIKSSKVLGLNADQTSKPLPISSEIIHPKERKMPPLNPRY 191
++ D G + A IK K+ +KPL + ++K ++
Sbjct: 1654 NINGAHD---GGATGGAVDIKPKTE----------TKPLVPEPLAPNAGDKKK---KCQF 1697
Query: 192 NKHELDTSLM-IIRKVMKMDAAE-PFNVPVNPEALGIPDYFDIIDTPMDFGTICSNLEKN 249
N EL T+L+ + K+ + + PF PV+P+ALGIPDYF+I+ PMD GTI +N++ N
Sbjct: 1698 NPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQ-N 1756
Query: 250 DKYMNSEDVYNDVRYIWENCYKYNNK 275
KY + + +DV +++N + YN K
Sbjct: 1757 GKYSDPWEYVDDVWLMFDNAWLYNPK 1782
Database: nr
Posted date: Jul 5, 2005 12:34 AM
Number of letters in database: 863,360,394
Number of sequences in database: 2,540,612
Lambda K H
0.305 0.127 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 944,602,152
Number of Sequences: 2540612
Number of extensions: 46224820
Number of successful extensions: 402172
Number of sequences better than 10.0: 6474
Number of HSP's better than 10.0 without gapping: 2085
Number of HSP's successfully gapped in prelim test: 4767
Number of HSP's that attempted gapping in prelim test: 260649
Number of HSP's gapped (non-prelim): 50737
length of query: 496
length of database: 863,360,394
effective HSP length: 132
effective length of query: 364
effective length of database: 527,999,610
effective search space: 192191858040
effective search space used: 192191858040
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 77 (34.3 bits)
Medicago: description of AC140550.8