BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC136287.1 + phase: 1 /partial
(436 letters)
Database: nr
2,540,612 sequences; 863,360,394 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gb|AAC23420.2| putative methylenetetrahydrofolate reductase [Ara... 739 0.0
gb|AAK43892.1| putative methylenetetrahydrofolate reductase [Ara... 739 0.0
pir||T00696 probable methylenetetrahydrofolate reductase [import... 739 0.0
emb|CAB53783.1| methylenetetrahydrofolate reductase [Arabidopsis... 738 0.0
ref|XP_470089.1| putative methylenetetrahydrofolate reductase [O... 732 0.0
emb|CAB75816.1| methylenetetrahydrofolate reductase MTHFR1 [Arab... 727 0.0
gb|AAD51733.1| methylenetetrahydrofolate reductase [Zea mays] 716 0.0
gb|AAL91367.2| chimera1 [synthetic construct] 553 e-156
ref|NP_850724.1| methylenetetrahydrofolate reductase 1 (MTHFR1) ... 416 e-115
ref|NP_850723.1| methylenetetrahydrofolate reductase 1 (MTHFR1) ... 414 e-114
gb|AAH46708.1| Mthfr-prov protein [Xenopus laevis] 408 e-112
gb|AAR01748.1| methylenetetrahydrofolate reductase, 3-partial [O... 403 e-111
gb|AAP88033.1| 5,10-methylenetetrahydrofolate reductase (NADPH) ... 398 e-109
emb|CAI15889.1| 5,10-methylenetetrahydrofolate reductase (NADPH)... 398 e-109
gb|AAA74440.2| methylenetetrahydrofolate reductase [synthetic co... 396 e-109
emb|CAB41971.1| methylenetetrahydrofolate reductase [Homo sapiens] 396 e-109
gb|AAH53509.1| 5,10-methylenetetrahydrofolate reductase (NADPH) ... 396 e-109
sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase gi|5278... 394 e-108
gb|EAK85422.1| hypothetical protein UM04612.1 [Ustilago maydis 5... 390 e-107
ref|XP_535405.1| PREDICTED: similar to methylenetetrahydrofolate... 387 e-106
>gb|AAC23420.2| putative methylenetetrahydrofolate reductase [Arabidopsis thaliana]
gi|5911427|gb|AAD55788.1| methylenetetrahydrofolate
reductase MTHFR2 [Arabidopsis thaliana]
gi|15215810|gb|AAK91450.1| At2g44160/F6E13.29
[Arabidopsis thaliana] gi|18406468|ref|NP_566011.1|
methylenetetrahydrofolate reductase 2 (MTHFR2)
[Arabidopsis thaliana] gi|22096355|sp|O80585|MTHR_ARATH
Methylenetetrahydrofolate reductase (MTHFR2)
Length = 594
Score = 739 bits (1907), Expect = 0.0
Identities = 346/433 (79%), Positives = 388/433 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVIG +GLA+ E YQSDL YLK K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+C
Sbjct: 156 AHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNY+GF+RMTGFCKTKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK++
Sbjct: 216 PIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKML 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHG+K++HLYTLNMEKSALAIL +LG+I+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GWE +P GRW DS + SYGAL+D+QF RPRA+DKKL +EW VPLKS+EDI
Sbjct: 336 PKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQ 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
E+F+ CLG L+++PWSELDGLQPET+IINE L K+N+KGFLTINSQP+VN E+SDSP V
Sbjct: 396 EKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTV 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGP GY+YQKAYLEFFCSKEKLDA++EK K P +TYMAVNK W SN Q DVNAV
Sbjct: 456 GWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFPAKEIIQPTIVDP SFNVWKDEAFE WSR WA+LYPEAD SR L+EEV +SY+LV
Sbjct: 516 TWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLV 575
Query: 421 SLVDNDYANGDLF 433
SLV+NDY NGD+F
Sbjct: 576 SLVENDYINGDIF 588
>gb|AAK43892.1| putative methylenetetrahydrofolate reductase [Arabidopsis thaliana]
Length = 594
Score = 739 bits (1907), Expect = 0.0
Identities = 346/433 (79%), Positives = 388/433 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVIG +GLA+ E YQSDL YLK K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+C
Sbjct: 156 AHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNY+GF+RMTGFCKTKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK++
Sbjct: 216 PIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKML 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHG+K++HLYTLNMEKSALAIL +LG+I+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GWE +P GRW DS + SYGAL+D+QF RPRA+DKKL +EW VPLKS+EDI
Sbjct: 336 PKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQ 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
E+F+ CLG L+++PWSELDGLQPET+IINE L K+N+KGFLTINSQP+VN E+SDSP V
Sbjct: 396 EKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTV 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGP GY+YQKAYLEFFCSKEKLDA++EK K P +TYMAVNK W SN Q DVNAV
Sbjct: 456 GWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFPAKEIIQPTIVDP SFNVWKDEAFE WSR WA+LYPEAD SR L+EEV +SY+LV
Sbjct: 516 TWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLV 575
Query: 421 SLVDNDYANGDLF 433
SLV+NDY NGD+F
Sbjct: 576 SLVENDYINGDIF 588
>pir||T00696 probable methylenetetrahydrofolate reductase [imported] -
Arabidopsis thaliana
Length = 606
Score = 739 bits (1907), Expect = 0.0
Identities = 346/433 (79%), Positives = 388/433 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVIG +GLA+ E YQSDL YLK K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+C
Sbjct: 168 AHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISC 227
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNY+GF+RMTGFCKTKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK++
Sbjct: 228 PIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKML 287
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHG+K++HLYTLNMEKSALAIL +LG+I+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 288 AHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 347
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GWE +P GRW DS + SYGAL+D+QF RPRA+DKKL +EW VPLKS+EDI
Sbjct: 348 PKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQ 407
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
E+F+ CLG L+++PWSELDGLQPET+IINE L K+N+KGFLTINSQP+VN E+SDSP V
Sbjct: 408 EKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTV 467
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGP GY+YQKAYLEFFCSKEKLDA++EK K P +TYMAVNK W SN Q DVNAV
Sbjct: 468 GWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAV 527
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFPAKEIIQPTIVDP SFNVWKDEAFE WSR WA+LYPEAD SR L+EEV +SY+LV
Sbjct: 528 TWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLV 587
Query: 421 SLVDNDYANGDLF 433
SLV+NDY NGD+F
Sbjct: 588 SLVENDYINGDIF 600
>emb|CAB53783.1| methylenetetrahydrofolate reductase [Arabidopsis thaliana]
Length = 594
Score = 738 bits (1904), Expect = 0.0
Identities = 346/433 (79%), Positives = 388/433 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVIG +GLA+ E YQSDL YLK K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+C
Sbjct: 156 AHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNY+GF+RMTGFCKTKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK++
Sbjct: 216 PIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKML 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHG+K++HLYTLNMEKSALAIL +LG+I+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GWE +P GRW DS + SYGAL+D+QF RPRA+DKKL +EW VPLKS+EDI
Sbjct: 336 PKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQ 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
E+F+ CLG L+++PWSELDGLQPET+IINE L K+N+KGFLTINSQP+VN E+SDSP V
Sbjct: 396 EKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTV 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGP GY+YQKAYLEFFCSKEKLDA++EK K P +TYMAVNK W SN Q DVNAV
Sbjct: 456 GWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTVQADVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFPAKEIIQPTIVDP SFNVWKDEAFE WSR WA+LYPEAD SR L+EEV +SY+LV
Sbjct: 516 TWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLV 575
Query: 421 SLVDNDYANGDLF 433
SLV+NDY NGD+F
Sbjct: 576 SLVENDYINGDIF 588
>ref|XP_470089.1| putative methylenetetrahydrofolate reductase [Oryza sativa
(japonica cultivar-group)] gi|40786561|gb|AAR89836.1|
putative methylenetetrahydrofolate reductase [Oryza
sativa (japonica cultivar-group)]
Length = 594
Score = 732 bits (1890), Expect = 0.0
Identities = 352/433 (81%), Positives = 383/433 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPD I + AT E Y +DLAYLK KVDAGADLI+TQLFYDTDIFLKFVNDCRQIGITC
Sbjct: 156 AHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNYKGF+RMTGFCKTKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+
Sbjct: 216 PIVPGIMPINNYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
A GIKT+HLYTLNMEKSAL IL +LGLIEESKISRSLPWR PTNVFRVKEDVRPIFWANR
Sbjct: 276 ATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT+GW+QYPHGRW DS NPSYGALTDYQF RPR + KKL EEWAVP+KS+EDI
Sbjct: 336 PKSYISRTLGWDQYPHGRWGDSRNPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDIN 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
ERF FC GKL ++PWSELDGLQPETKII++ L KIN KGFLTINSQPAVNGE+SDS V
Sbjct: 396 ERFMNFCQGKLTSSPWSELDGLQPETKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSV 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGPGGY+YQKAYLEFFCSKEKLD LIEKSK P LTY+AVNK+G SN+ VNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCSKEKLDQLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFP KEI+QPT+VD SF VWKDEAFEIWS+GWA L+PE D+SR+++++V SYFLV
Sbjct: 516 TWGVFPGKEIVQPTVVDSASFMVWKDEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLV 575
Query: 421 SLVDNDYANGDLF 433
SLVDNDY NGDLF
Sbjct: 576 SLVDNDYINGDLF 588
>emb|CAB75816.1| methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis thaliana]
gi|21689667|gb|AAM67455.1| putative
methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis
thaliana] gi|17979047|gb|AAL49791.1| putative
methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis
thaliana] gi|5911425|gb|AAD55787.1|
methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis
thaliana] gi|15232215|ref|NP_191556.1|
methylenetetrahydrofolate reductase 1 (MTHFR1)
[Arabidopsis thaliana] gi|11280412|pir||T47821
methylenetetrahydrofolate reductase MTHFR1 - Arabidopsis
thaliana
Length = 592
Score = 727 bits (1876), Expect = 0.0
Identities = 339/433 (78%), Positives = 381/433 (87%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVI ADGLAT E YQSDLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGI C
Sbjct: 156 AHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPI+NYKGF+RM GFCKTKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKI+
Sbjct: 216 PIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHGI ++HLYTLN++KSA+ IL +LGLI+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GW +PHGRW DS + +Y L+DYQF RP+ +DKKL +EW VPLKSIED+
Sbjct: 336 PKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQ 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
E+F+ C+G L+++PWSELDGLQPETKIINE L KIN+ GFLTINSQP+VN KSDSP +
Sbjct: 396 EKFKELCIGNLKSSPWSELDGLQPETKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAI 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGPGGY+YQKAYLEFFCSK+KLD L+EKSK P +TYMAVNK W SN G++DVNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCSKDKLDTLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFPAKE+IQPTIVDP SF VWKDEAFEIWSR WA+LYPE D SRKL+EEV +SY+LV
Sbjct: 516 TWGVFPAKEVIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLV 575
Query: 421 SLVDNDYANGDLF 433
SLVDN+Y NGD+F
Sbjct: 576 SLVDNNYINGDIF 588
>gb|AAD51733.1| methylenetetrahydrofolate reductase [Zea mays]
Length = 593
Score = 716 bits (1848), Expect = 0.0
Identities = 340/433 (78%), Positives = 377/433 (86%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPD I +G AT E Y +DLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC
Sbjct: 156 AHPDAIQGEGGATLEAYSNDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNYKGF+RMTGFCKTKIP+EI AAL+PIKDNEEAV+ YGIHLGTEMCKKI+
Sbjct: 216 PIVPGIMPINNYKGFLRMTGFCKTKIPSEITAALDPIKDNEEAVRQYGIHLGTEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
A GIKT+HLYTLNM+KSA+ IL +LGLIEESK+SR LPWR TNVFRVKEDVRPIFWANR
Sbjct: 276 ATGIKTLHLYTLNMDKSAIGILMNLGLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSY+ RT+GW+QYPHGRW DS NPSYGALTD+QF RPR + KKL EEWAVPLKS+EDI
Sbjct: 336 PKSYLKRTLGWDQYPHGRWGDSRNPSYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDIS 395
Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
ERF FC GKL ++PWSELDGLQPETKII++ L IN KGFLTINSQPAVNGEKSDSP V
Sbjct: 396 ERFTNFCQGKLTSSPWSELDGLQPETKIIDDQLVNINQKGFLTINSQPAVNGEKSDSPTV 455
Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
GWGGPGGY+YQKAYLEFFC+KEKLD LIEK K P LTY+AVNK+G SN+ VNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCAKEKLDQLIEKIKAFPSLTYIAVNKDGETFSNISPNAVNAV 515
Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
TWGVFP KEIIQPT+VD SF VWKDEAFEIW+RGW ++PE D+SR+L+E+V +Y+LV
Sbjct: 516 TWGVFPGKEIIQPTVVDHASFMVWKDEAFEIWTRGWGCMFPEGDSSRELLEKVQKTYYLV 575
Query: 421 SLVDNDYANGDLF 433
SLVDNDY GDLF
Sbjct: 576 SLVDNDYVQGDLF 588
>gb|AAL91367.2| chimera1 [synthetic construct]
Length = 594
Score = 553 bits (1426), Expect = e-156
Identities = 260/420 (61%), Positives = 322/420 (75%), Gaps = 6/420 (1%)
Query: 20 DLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMT 79
DL YLK K+DAG D I+TQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R
Sbjct: 171 DLEYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRA 230
Query: 80 GFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVHLYTLNMEKSA 138
+ + IP + L+PIKD++E V+ G +L EMC+K++ G + +H+YT+N+EK+
Sbjct: 231 QWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAP 290
Query: 139 LAILTSLGLIE-ESKISRS----LPWRRPTNVFRVKEDVRPIFWANRPKSYISRTIGWEQ 193
L IL L ++ ES+ + LPWR+ N R E+VRPIFWANRPKSYISRT GW
Sbjct: 291 LMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWANRPKSYISRTKGWND 350
Query: 194 YPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIYERFRLFCLGKLRT 253
+PHGRW DS + +Y L+DYQF RP+ +DKKL +EW VPLKSIED+ E+F+ C+G L++
Sbjct: 351 FPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQEKFKELCIGNLKS 410
Query: 254 NPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIVGWGGPGGYIYQKA 313
+PWSELDGLQPETKIINE L KIN+ GFLTINSQP+VN KSDSP +GWGGPGGY+YQKA
Sbjct: 411 SPWSELDGLQPETKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKA 470
Query: 314 YLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAVTWGVFPAKEIIQP 373
YLEFFCSK+KLD L+EKSK P +TYMAVNK W SN G++DVNAVTWGVFPAKE+IQP
Sbjct: 471 YLEFFCSKDKLDTLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAVTWGVFPAKEVIQP 530
Query: 374 TIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLVSLVDNDYANGDLF 433
TIVDP SF VWKDEAFEIWSR WA+LYPE D SRKL+EEV +SY+LVSLVDN+Y NGD+F
Sbjct: 531 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNNYINGDIF 590
>ref|NP_850724.1| methylenetetrahydrofolate reductase 1 (MTHFR1) [Arabidopsis
thaliana]
Length = 407
Score = 416 bits (1069), Expect = e-115
Identities = 195/242 (80%), Positives = 215/242 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVI ADGLAT E YQSDLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGI C
Sbjct: 156 AHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPI+NYKGF+RM GFCKTKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKI+
Sbjct: 216 PIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHGI ++HLYTLN++KSA+ IL +LGLI+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GW +PHGRW DS + +Y L+DYQF RP+ +DKKL +EW VPLKSIED+
Sbjct: 336 PKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQ 395
Query: 241 ER 242
ER
Sbjct: 396 ER 397
>ref|NP_850723.1| methylenetetrahydrofolate reductase 1 (MTHFR1) [Arabidopsis
thaliana]
Length = 421
Score = 414 bits (1064), Expect = e-114
Identities = 194/241 (80%), Positives = 214/241 (88%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPDVI ADGLAT E YQSDLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGI C
Sbjct: 156 AHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPI+NYKGF+RM GFCKTKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKI+
Sbjct: 216 PIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
AHGI ++HLYTLN++KSA+ IL +LGLI+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
PKSYISRT GW +PHGRW DS + +Y L+DYQF RP+ +DKKL +EW VPLKSIED+
Sbjct: 336 PKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQ 395
Query: 241 E 241
E
Sbjct: 396 E 396
>gb|AAH46708.1| Mthfr-prov protein [Xenopus laevis]
Length = 643
Score = 408 bits (1049), Expect = e-112
Identities = 201/438 (45%), Positives = 280/438 (63%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G AE Y DL +LK K+DAGAD I+TQLF+ ++ FL F+ DCR IGITCP++PGI PI
Sbjct: 194 GHPDAESYDQDLKHLKEKIDAGADFIITQLFFRSETFLTFLKDCRAIGITCPVLPGIFPI 253
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EIM +EPIKDN+ A++ YGI L MC++++ G + +H
Sbjct: 254 QGYGSLRQLVKLSKLEVPQEIMDVIEPIKDNDAAIRNYGIDLAVSMCRELLDSGLVHGLH 313
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + + +L LG+ +E R +PW + R EDVRPIFWA+RPKSYI RT
Sbjct: 314 FYTLNREVATIDVLKRLGMWKEDP-RRPMPWAMSAHPKRRVEDVRPIFWASRPKSYIHRT 372
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S E ++E F +
Sbjct: 373 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGQELNSEESVFEVFTYY 432
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ D L PET ++ L+K+N +G LTINSQP VNG+ S PI
Sbjct: 433 ISGEPNPNGHKVNCLPWND-DPLAPETNLLKNELQKVNKRGILTINSQPNVNGKPSTDPI 491
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKD-RPFLTYMAVNKEGIWKSNVGQTDVN 358
VGWG GY++QKAYLEFF S E + ALI+ K P + Y VN G +N N
Sbjct: 492 VGWGPSRGYVFQKAYLEFFTSSEMVSALIKVLKRYEPRVNYHIVNVHGQNITNAADLQPN 551
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W WA LY E SR +++ + +Y+
Sbjct: 552 AVTWGIFPGREIIQPTVVDPVSFVYWKDEAFALWIEQWAKLYEEESPSRMIIQYIHDNYY 611
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 612 LVNLVDNDFPLENCLWQV 629
>gb|AAR01748.1| methylenetetrahydrofolate reductase, 3-partial [Oryza sativa
(japonica cultivar-group)]
Length = 374
Score = 403 bits (1035), Expect = e-111
Identities = 193/219 (88%), Positives = 202/219 (92%)
Query: 1 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
AHPD I + AT E Y +DLAYLK KVDAGADLI+TQLFYDTDIFLKFVNDCRQIGITC
Sbjct: 156 AHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITC 215
Query: 61 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
PIVPGIMPINNYKGF+RMTGFCKTKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+
Sbjct: 216 PIVPGIMPINNYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIL 275
Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
A GIKT+HLYTLNMEKSAL IL +LGLIEESKISRSLPWR PTNVFRVKEDVRPIFWANR
Sbjct: 276 ATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANR 335
Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPR 219
PKSYISRT+GW+QYPHGRW DS NPSYGALTDYQF RPR
Sbjct: 336 PKSYISRTLGWDQYPHGRWGDSRNPSYGALTDYQFTRPR 374
>gb|AAP88033.1| 5,10-methylenetetrahydrofolate reductase (NADPH) [Homo sapiens]
gi|55962393|emb|CAI15885.1|
5,10-methylenetetrahydrofolate reductase (NADPH) [Homo
sapiens] gi|56405339|sp|P42898|MTHR_HUMAN
Methylenetetrahydrofolate reductase
Length = 656
Score = 398 bits (1023), Expect = e-109
Identities = 196/438 (44%), Positives = 279/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C++++A G + +H
Sbjct: 260 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 319
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S E ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLY 438
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S PI
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 497
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 617
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635
>emb|CAI15889.1| 5,10-methylenetetrahydrofolate reductase (NADPH) [Homo sapiens]
Length = 697
Score = 398 bits (1023), Expect = e-109
Identities = 196/438 (44%), Positives = 279/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 241 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 300
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C++++A G + +H
Sbjct: 301 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 360
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 361 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 419
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S E ++E F L+
Sbjct: 420 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLY 479
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S PI
Sbjct: 480 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 538
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 539 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 598
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 599 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 658
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 659 LVNLVDNDFPLDNCLWQV 676
>gb|AAA74440.2| methylenetetrahydrofolate reductase [synthetic construct]
gi|4336819|gb|AAD17965.1| methylenetetrahydrofolate
reductase [Homo sapiens]
Length = 656
Score = 396 bits (1017), Expect = e-109
Identities = 195/438 (44%), Positives = 278/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C++++A G + +H
Sbjct: 260 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 319
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEASVFEVFVLY 438
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S PI
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 497
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 617
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635
>emb|CAB41971.1| methylenetetrahydrofolate reductase [Homo sapiens]
Length = 679
Score = 396 bits (1017), Expect = e-109
Identities = 195/438 (44%), Positives = 278/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 223 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 282
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C++++A G + +H
Sbjct: 283 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 342
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 343 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 401
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S ++E F L+
Sbjct: 402 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEASVFEVFVLY 461
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S PI
Sbjct: 462 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 520
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 521 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 580
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 581 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 640
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 641 LVNLVDNDFPLDNCLWQV 658
>gb|AAH53509.1| 5,10-methylenetetrahydrofolate reductase (NADPH) [Homo sapiens]
gi|40254829|ref|NP_005948.2|
5,10-methylenetetrahydrofolate reductase (NADPH) [Homo
sapiens]
Length = 656
Score = 396 bits (1017), Expect = e-109
Identities = 195/438 (44%), Positives = 278/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C++++A G + +H
Sbjct: 260 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 319
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEASVFEVFVLY 438
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S PI
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 497
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYF 617
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635
>sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase gi|52782247|dbj|BAD51970.1|
5,10-methylenetetrahydrofolate reductase [Macaca
fascicularis]
Length = 656
Score = 394 bits (1012), Expect = e-108
Identities = 194/438 (44%), Positives = 277/438 (62%), Gaps = 13/438 (2%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL +LK KV AGAD I+TQLF++ D F +FV C +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P EI +EPIKDN+ A++ YGI L +C +++A G + +H
Sbjct: 260 QGYHSLRQLVKQSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLH 319
Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
YTLN E + +L LG+ E R LPW + R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378
Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
W+++P+GRW +S +P++G L DY +++ ++ + L++ W L S E ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPRELLLKMWGEELTSEESVFEVFVLY 438
Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
G+ N PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S P+
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPV 497
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
VGWG GGY++QKAYLEFF S+E +AL++ K + Y VN +G +N + N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557
Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
AVTWG+FP +EIIQPT+VDP+SF WKDEAF +W W LY E SR +++ + +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYF 617
Query: 419 LVSLVDNDYANGDLFWCV 436
LV+LVDND+ + W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635
>gb|EAK85422.1| hypothetical protein UM04612.1 [Ustilago maydis 521]
gi|49076524|ref|XP_402227.1| hypothetical protein
UM04612.1 [Ustilago maydis 521]
Length = 650
Score = 390 bits (1001), Expect = e-107
Identities = 202/435 (46%), Positives = 278/435 (63%), Gaps = 15/435 (3%)
Query: 2 HPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCP 61
HP+ I +G + +L LK K++AGAD I TQ+FYD DIF K+V D R GI CP
Sbjct: 173 HPEAI--------DGPELELERLKEKIEAGADFIFTQMFYDFDIFAKWVKDVRAAGINCP 224
Query: 62 IVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMA 121
I+PG+MPI Y GF R T T +P AL+P++D+++ V+ G L EMCKKI+
Sbjct: 225 IIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVRDDDQKVREIGTRLVGEMCKKIVG 284
Query: 122 HG--IKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWAN 179
G I +H+YT+N+EK + +L LGL LPW R +E +RPIFWAN
Sbjct: 285 TGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPLPWTPSLTPKRREEKIRPIFWAN 344
Query: 180 RPKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDI 239
R KSY++RT W+++P+GRW D+ +P+YG + Y ++ R +++ E W P ++D+
Sbjct: 345 RAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VKLRYSNEEAKEMWGAPT-CLDDV 402
Query: 240 YERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
F+ FC G+++ PWSE + ET +I++ L K+N GFLTINSQPAV+G +SD +
Sbjct: 403 KTLFQQFCAGQVKALPWSETP-VARETSVISDKLAKMNQLGFLTINSQPAVDGARSDDKV 461
Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNA 359
GWG GY+YQKAYLEFF S E LDALI + + P +TY AVN +G ++N NA
Sbjct: 462 HGWGPKNGYVYQKAYLEFFVSPEDLDALIARIEADPQITYHAVNSQGDMRTNTNSEAPNA 521
Query: 360 VTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFL 419
VTWGVFP EIIQPTIV+ +SF WKDEA+EI R WA +Y SRK +E++ +SYFL
Sbjct: 522 VTWGVFPHCEIIQPTIVESISFLAWKDEAYEI-GRNWAKVYEPTSPSRKFLEDMFNSYFL 580
Query: 420 VSLVDNDY-ANGDLF 433
V++V ND+ AN +F
Sbjct: 581 VNVVHNDFKANDSIF 595
>ref|XP_535405.1| PREDICTED: similar to methylenetetrahydrofolate reductase [Canis
familiaris]
Length = 774
Score = 387 bits (995), Expect = e-106
Identities = 192/439 (43%), Positives = 279/439 (62%), Gaps = 15/439 (3%)
Query: 10 GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
G A +++DL YLK KV AGAD I+TQLF++ D F FV C +IGITCPI+PGI PI
Sbjct: 319 GHPDAGSFEADLKYLKEKVSAGADFIITQLFFEADTFFHFVKACSEIGITCPILPGIFPI 378
Query: 70 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
Y ++ K ++P +I +EPIKDN+ A++ YGI +C++++ G + +H
Sbjct: 379 QGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLTSGLVPGLH 438
Query: 129 LYTLNMEKSALAILTSLGL-IEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISR 187
YTLN E + +L LG+ IE+ + R LPW + R +EDVRPIFWA+RPKSYI R
Sbjct: 439 FYTLNREMATTEVLKRLGMWIEDPR--RPLPWAVSAHPKRREEDVRPIFWASRPKSYIYR 496
Query: 188 TIGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRL 245
T W+++P+GRW +S +P++G L DY +++ ++ ++L++ W L S E ++E F
Sbjct: 497 TQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFAR 556
Query: 246 FCLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSP 298
+ G K+ PW++ + L ET ++ E L ++N +G LTINSQP +NG+ S P
Sbjct: 557 YLSGEPNQHGYKVTCLPWND-EPLAAETSLMKEELLRVNRQGILTINSQPNINGKPSSDP 615
Query: 299 IVGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDV 357
IVGWG GGY++QKAYLEFF S+E + AL++ K + Y V+ +G +N +
Sbjct: 616 IVGWGPSGGYVFQKAYLEFFTSRETVGALLQVLKKYELRVNYHIVDVKGENITNAPELQP 675
Query: 358 NAVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSY 417
NAVTWG+FP +EIIQPT+VDPVSF WKDEAF +W W LY E SR +++ + +Y
Sbjct: 676 NAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNY 735
Query: 418 FLVSLVDNDYANGDLFWCV 436
FLV+LVDN++ + W V
Sbjct: 736 FLVNLVDNEFPLDNCLWQV 754
Database: nr
Posted date: Jul 5, 2005 12:34 AM
Number of letters in database: 863,360,394
Number of sequences in database: 2,540,612
Lambda K H
0.319 0.138 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 795,929,902
Number of Sequences: 2540612
Number of extensions: 34896128
Number of successful extensions: 68448
Number of sequences better than 10.0: 245
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 67916
Number of HSP's gapped (non-prelim): 264
length of query: 436
length of database: 863,360,394
effective HSP length: 131
effective length of query: 305
effective length of database: 530,540,222
effective search space: 161814767710
effective search space used: 161814767710
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 77 (34.3 bits)
Medicago: description of AC136287.1