BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0559.7
         (442 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

HGV2_HALRO (Q02508) Protein HGV2                                       80  8e-15
HIBN_XENLA (P06180) Histone-binding protein N1/N2                      78  5e-14
NASP_RABIT (P27123) Nuclear autoantigenic sperm protein (NASP)         74  1e-12
NASP_HUMAN (P49321) Nuclear autoantigenic sperm protein (NASP)         72  2e-12
NUCL_XENLA (P20397) Nucleolin (Protein C23)                            52  3e-06
RA50_HALVO (P62133) DNA double-strand break repair rad50 ATPase        52  4e-06
NUCL_HUMAN (P19338) Nucleolin (Protein C23)                            51  7e-06
SR40_YEAST (P32583) Suppressor protein SRP40                           50  9e-06
TPM3_MOUSE (P21107) Tropomyosin alpha 3 chain (Tropomyosin 3) (T...    49  2e-05
TPM1_RANTE (P13105) Tropomyosin 1 alpha chain (Alpha-tropomyosin)      49  2e-05
TPM3_HUMAN (P06753) Tropomyosin alpha 3 chain (Tropomyosin 3) (T...    49  3e-05
EP15_MOUSE (P42567) Epidermal growth factor receptor substrate 1...    49  3e-05
TPM4_RAT (P09495) Tropomyosin alpha 4 chain (Tropomyosin 4) (TM-4)     48  4e-05
TPM1_XENLA (Q01173) Tropomyosin 1 alpha chain (Alpha-tropomyosin)      48  4e-05
DMP1_HUMAN (Q13316) Dentin matrix acidic phosphoprotein 1 precur...    47  8e-05
TPM4_MOUSE (Q6IRU2) Tropomyosin alpha 4 chain (Tropomyosin 4)          47  1e-04
SMC2_XENLA (P50533) Structural maintenance of chromosome 2 (Chro...    47  1e-04
MYH6_MESAU (P13539) Myosin heavy chain, cardiac muscle alpha iso...    47  1e-04
TPM4_PIG (P67937) Tropomyosin alpha 4 chain (Tropomyosin 4)            47  1e-04
TPM4_HUMAN (P67936) Tropomyosin alpha 4 chain (Tropomyosin 4) (T...    47  1e-04

>HGV2_HALRO (Q02508) Protein HGV2
          Length = 510

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 95/444 (21%), Positives = 176/444 (39%), Gaps = 98/444 (22%)

Query: 52  ESASNAETSGKNSLELAV-ELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECV 110
           E+ ++ ET     +E  + E M  G K +  +D+ EA   F  A  +    +G++A EC 
Sbjct: 9   EAGTSKETETTVDVEKEIQECMGAGKKDLLCNDYSEAVNCFQEACTLLSGKHGQMAEECC 68

Query: 111 NTYYKYGCALL-------------YKAQEEADPLGDVPKKQEGSQH---GSSKDESVKST 154
             YY YG +LL              K   E D  GD  ++QE  +      ++ E ++  
Sbjct: 69  EAYYYYGVSLLELARLENGVLGNALKGVPEEDADGDSDQEQEQFEKPDLPETEREKLREE 128

Query: 155 INAA----------------------------ESSTAASFSSNAEQDIASNDQESAVDDE 186
           + AA                            ES  +A  S   E++    ++++ V+  
Sbjct: 129 VEAAMATEDEDTQEERGCPRRVEKKKEDDKPKESEKSAEKSDEKEKE----EKQAKVESS 184

Query: 187 STKNYQEEDDED------------------SDAEDTEADEDESD---LDLAWKMLDIARA 225
           + K+ ++E   D                  S +++ E++ED  D   + LAW+ML++A+ 
Sbjct: 185 TVKDVKDEKSSDKPVESSNTEEPGTSGTSASSSKENESEEDPDDISNMQLAWEMLELAKV 244

Query: 226 IVEKQCVNTIEHVDILS---TLAEISLEREEFENSLSDYQKALSILEQLV---------- 272
           + +K   +      +      L E+ LE E    ++ D+ + L I + L+          
Sbjct: 245 LYKKHDKSKTNKQMVAQCHLKLGELGLEVENHPQAIGDFLECLVIQKDLLPETDRKLAET 304

Query: 273 ----------DSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEI 322
                     + + + A+ + + A  V +AR+D L NE+      ++ K K I  +  E+
Sbjct: 305 YYNLGLAYSFEKRYDNALEHYQSALDVLEARVDML-NELIESNEGNKEKEKEIISECKEV 363

Query: 323 ETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKESIPAKVSSSQLATANS 382
             L  L  D+ +K+ED+ L     K  + +L      +A  G+ S     S+S     ++
Sbjct: 364 GELKELIPDINSKIEDVIL----AKKQMQKLDGSPFRQASEGESSSGLGASTSDDKPCST 419

Query: 383 SGGFDSPTISTAHSNGSAAGVTHL 406
                    S   +  S + +THL
Sbjct: 420 IPIRKVAPTSVPVAKDSPSDITHL 443


>HIBN_XENLA (P06180) Histone-binding protein N1/N2
          Length = 589

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 94/431 (21%), Positives = 176/431 (40%), Gaps = 66/431 (15%)

Query: 51  AESASNAETSGKNSLELAVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECV 110
           +ES +  +  G +  + A E M  G K  ++       ++ SR + +  +  GE  PE  
Sbjct: 154 SESEAKGKPEGDSKDKEADEKMKNGQKETEKVTDDLKIDSASRDVPMDKSGKGE-PPESK 212

Query: 111 NTYYKYGCALLYKAQEEADPLGDVPKKQEGSQHGSSKDES-VKSTINAAESST------- 162
           +       A     Q+E+ P     K  E  +   SK+++  K T N +  ST       
Sbjct: 213 D-------AETLVEQKESKPETLKEKSIETKEKDLSKEKTDAKETANQSPDSTEVAEEKM 265

Query: 163 -AASFSSNAEQDIASNDQESAVDDESTKNYQEEDDEDSDA--------EDTEA----DED 209
            + +  S     I   + E+   D+  K  +EE+ EDS+         E TE     +ED
Sbjct: 266 DSEASESKESTSIPPTENEANKPDDPEKMEEEEEGEDSEENEDGTEENEGTEEKETEEED 325

Query: 210 ESDLDLAWKMLDIARAIVEKQCVN--TIEHVDILSTLAEISLEREEFENSLSDYQKALSI 267
             +L LAW+MLD+ + I ++Q      ++       L E+ +E E +  ++ D+   L+I
Sbjct: 326 VGNLQLAWEMLDLCKTIFKRQQSKEAQLKAAQAHQKLGEVCIESENYSQAVEDFLACLNI 385

Query: 268 LEQLVD--------------------SKPEEAIAYCEKAASVCKARLDRLTNEVKSITPA 307
            ++ ++                    SK EEAI++  ++  V + R+D LT ++++    
Sbjct: 386 QKEHLEEHDRLLAETHYHLGLAYQYSSKHEEAISHFTQSIGVIEKRMDVLTKQLEA---- 441

Query: 308 SEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKES 367
             +  + +++ + E++ L  L  D++ K+ED +    N   T   L E +   + G    
Sbjct: 442 --SVGELVDEVKKEMDELKDLLPDIKEKIEDSKEAQKNATVTEKALKETLVGGSSG---- 495

Query: 368 IPAKVSSSQLATANSSGGFDSPTISTAHSNGSAAGVTHLGVVGRGVKRTSLAPEASAPKK 427
                 S +  + +SS   +    ST       + ++HL    R  +  S   +  A K 
Sbjct: 496 -----FSKENGSTSSSSAVEKSGDSTVPVTNCVSDISHLVRKKRKTEEESPLKDKDAKKS 550

Query: 428 PALESTEGKGD 438
                  G G+
Sbjct: 551 KQEPVANGAGN 561



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 81/337 (24%), Positives = 136/337 (40%), Gaps = 31/337 (9%)

Query: 51  AESASNAETSGKNSLELAVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECV 110
           A S S  +  G +    A  LM  G K +   D   A   F  A  +    YGE A EC 
Sbjct: 18  APSTSAEKADGIDIDTEAKRLMGAGQKHLVMKDVRSAVNLFQEASSLLAKQYGETADECA 77

Query: 111 NTYYKYGCALLYKAQEEADPLGD-VPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSN 169
             +Y YG +LL  A+ E   LG+ +    E  +  + K+E     I +A++         
Sbjct: 78  EAFYSYGMSLLELARLENGVLGNALEGMPEDDEEEAEKEED--PNIPSADNLDEKEREQL 135

Query: 170 AEQ--DIASNDQESAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIV 227
            EQ  D  + DQ +  D   T   + +   + D++D EADE   +               
Sbjct: 136 REQVYDAMAEDQRAPDD---TSESEAKGKPEGDSKDKEADEKMKN--------------G 178

Query: 228 EKQCVNTIEHVDILSTLAEISLEREEFENSLSDYQKALSILEQLVDSKP----EEAIAYC 283
           +K+     + + I S   ++ +++   +    + + A +++EQ  +SKP    E++I   
Sbjct: 179 QKETEKVTDDLKIDSASRDVPMDKSG-KGEPPESKDAETLVEQ-KESKPETLKEKSIETK 236

Query: 284 EKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLV 343
           EK  S  K       N+    T  +E K  S E  +++  T    + +  NK +D + + 
Sbjct: 237 EKDLSKEKTDAKETANQSPDSTEVAEEKMDS-EASESKESTSIPPTENEANKPDDPEKME 295

Query: 344 SNPKSTLSELLEKVAAKAGG--GKESIPAKVSSSQLA 378
              +   SE  E    +  G   KE+    V + QLA
Sbjct: 296 EEEEGEDSEENEDGTEENEGTEEKETEEEDVGNLQLA 332


>NASP_RABIT (P27123) Nuclear autoantigenic sperm protein (NASP)
          Length = 680

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 91/366 (24%), Positives = 153/366 (40%), Gaps = 82/366 (22%)

Query: 131 LGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQD---IASNDQ-----ESA 182
           L +V  +   SQ      E  +   +  E+  A   +  + +D   IA+N++     E  
Sbjct: 304 LEEVRAELAPSQEAKLPIEESEGAGDGVETKVAQGVTEKSPEDKVKIAANEETQEREEQM 363

Query: 183 VDDESTKNYQEEDDEDSDAEDT-------------EADEDE-SDLDLAWKMLDIARAIVE 228
            + E T+  +EED E+  AE+              E +E+E  +L+LAW MLD+A+ I +
Sbjct: 364 KEGEETEGSEEEDKENDKAEEETPNDSVLENKSLPENEEEEIGNLELAWDMLDLAKIIFK 423

Query: 229 KQCVNTIE--HVDILSTLAEISLEREEFENSLSDYQKALSILEQLVD------------- 273
           +Q     +         L E+S+E + +  ++ ++Q  LS+ EQ ++             
Sbjct: 424 RQETKEAQLYAAQAHLKLGEVSVESQNYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQL 483

Query: 274 -------SKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLT 326
                  S+ +EA+A   K+  V + R+  L  ++K      EA+  S E  + EIE L 
Sbjct: 484 GLAYGYNSQYDEAVAQFSKSIEVIEKRMAVLNEQMK------EAEGSSTE-YEKEIEELK 536

Query: 327 GLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKESIPAKVSSSQLATANSSGGF 386
            L  ++  K+ED +      +S  S  + ++A KA          V SS      S GG 
Sbjct: 537 ELLPEIREKIEDAK------ESQRSGNVAELALKA--------TLVGSSTSGFTPSGGGS 582

Query: 387 DSPTIST------AHSNGSAAGVTHLGVVGRGVKRTSLAPEASAPK----KPALESTEGK 436
              TI++      A S+     ++HL        R    PE  +P+    K A +  E  
Sbjct: 583 SVSTIASRKPADGASSSNCVTDISHL-------VRKKRKPEEESPRKDDAKKAKQEPEVN 635

Query: 437 GDSGSA 442
           G SG A
Sbjct: 636 GGSGDA 641



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 52/224 (23%), Positives = 87/224 (38%), Gaps = 23/224 (10%)

Query: 3   EEAPASETSVSMAPSEEAVAVDGTLNPSEHGKSEITNGATVDSAAI---GGAESASNAET 59
           EE P          +E +   +G   P    ++E+T+G +   AA    G + S ++ + 
Sbjct: 93  EELPEKVALTPDQLTETSEEAEGAAAPEGLNEAEVTSGKSEQEAADAEKGKSVSGTDVQE 152

Query: 60  SGKNSLEL----AVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECVNTYYK 115
             K  +E      +  ++K T+A +E   G      + A+E+          E V+   K
Sbjct: 153 EHKEQVEEKQGEVIVRIEKPTEASEEQP-GTTLGKDNTAVEVEA--------EPVDATAK 203

Query: 116 YGCALLYKAQEEADPLGDVPKKQEGSQHGSSKD-----ESVKSTINAAESSTAASFSSNA 170
                 ++ +E+    G+ P K   +Q    +D     ES   T  AAE  +  S  S  
Sbjct: 204 PVDVGGHEPKEQMATSGNEPGKAVLNQQLVGQDVPPVEESPMVTTEAAEVGSEVSEKSEQ 263

Query: 171 EQDIASNDQESAVDDESTKNYQEEDDEDSDAEDTEADEDESDLD 214
           E  + SND   AV+  S    Q   D    AE     +  S+L+
Sbjct: 264 EATVVSND--GAVNGLSAAGDQASVDPQPSAERVTETKGGSELE 305


>NASP_HUMAN (P49321) Nuclear autoantigenic sperm protein (NASP)
          Length = 788

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 91/357 (25%), Positives = 147/357 (40%), Gaps = 78/357 (21%)

Query: 126 EEADPLGDV--PKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAV 183
           EE++  GD    K  +G+   S +D   K  I A E +         EQ     + E + 
Sbjct: 430 EESEAAGDGVDTKVAQGATEKSPED---KVQIAANEET-----QEREEQMKEGEETEGSE 481

Query: 184 DDESTKNYQEEDDEDSDAEDTEADEDESD----LDLAWKMLDIARAIVEKQCVNTIE--H 237
           +D+   +  EE   DS  E+    E+E +    L+LAW MLD+A+ I ++Q     +   
Sbjct: 482 EDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYA 541

Query: 238 VDILSTLAEISLEREEFENSLSDYQKALSILEQLVD--------------------SKPE 277
                 L E+S+E E +  ++ ++Q  L++ EQ ++                    S+ +
Sbjct: 542 AQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYD 601

Query: 278 EAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLE 337
           EA+A   K+  V + R+  L  +VK      EA+  S E K+ EIE L  L  ++  K+E
Sbjct: 602 EAVAQFSKSIEVIENRMAVLNEQVK------EAEGSSAEYKK-EIEELKELLPEIREKIE 654

Query: 338 DLQLLVSNPKSTLSELLEKVAA--------KAGGGKESIPAKVSSSQLATANSSGGFDSP 389
           D +   S     ++EL  K             GGG  S+      S +A+   + G    
Sbjct: 655 DAK--ESQRSGNVAELALKATLVESSTSGFTPGGGGSSV------SMIASRKPTDG---- 702

Query: 390 TISTAHSNGSAAGVTHLGVVGRGVKRTSLAPEASAPK----KPALESTEGKGDSGSA 442
               A S+     ++HL        R    PE  +P+    K A +  E  G SG A
Sbjct: 703 ----ASSSNCVTDISHL-------VRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDA 748



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 73/344 (21%), Positives = 133/344 (38%), Gaps = 41/344 (11%)

Query: 68  AVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECVNTYYKYGCALLYKAQEE 127
           A +L+  G K +   D   A   F  A  +    YGE A EC   ++ YG +LL  A+ E
Sbjct: 43  AKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME 102

Query: 128 ADPLGDV-----PKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESA 182
              LG+       +++EG +   ++DES+    +  +              +   ++   
Sbjct: 103 NGVLGNALEGVHVEEEEGEK---TEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKK 159

Query: 183 VDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILS 242
            +D+S    + + ++DS+ E    ++           +DI+++  E Q     E VD+  
Sbjct: 160 TEDKSLAKPETDKEQDSEMEKGGRED-----------MDISKSAEEPQ-----EKVDL-- 201

Query: 243 TLAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNE-- 300
           TL  ++   EE +   +      +   ++   KPE+ +   E+  SV    +     E  
Sbjct: 202 TLDWLTETSEEAKGGAAPEGPNEA---EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKG 258

Query: 301 ----VKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEK 356
                  +  + E K K + ++Q  + TL    + +E + E L   V        E  EK
Sbjct: 259 GQEKQGEVIVSIEEKPKEVSEEQ-PVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEK 317

Query: 357 VAAKAGGGKESIPAKVSSSQLATANSSGGFDSPTISTAHSNGSA 400
           V        E+   K    QL         +SP ++T  +  SA
Sbjct: 318 VVT-----SENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASA 356


>NUCL_XENLA (P20397) Nucleolin (Protein C23)
          Length = 650

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 60/239 (25%), Positives = 106/239 (44%), Gaps = 30/239 (12%)

Query: 134 VPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQES---------AVD 184
           V KK+E  +    +DES +    A + + A   +   ++    +D+ES         A+ 
Sbjct: 115 VAKKEESEEDDDDEDESEEEKAVAKKPTPAKKPAGKKQESEEEDDEESEDEPMEVAPALK 174

Query: 185 DESTKNYQEEDDEDSDAEDTEADEDESDLD-LAWKMLDIARAIVEKQCVNT---IEHVDI 240
            + T    EEDDE+ D +D E D+DE +    A +  ++ + I E +   T    E + I
Sbjct: 175 GKKTAQAAEEDDEEEDDDDEEDDDDEEEQQGSAKRKKEMPKTIPEAKKTKTDTASEGLSI 234

Query: 241 LSTLAEISLEREEFENSLSDY--QKALSILE---------QLVDSKPEEAIAYCEKAASV 289
                  + E +E +++L ++  +K L+I +           VD   EE +   EKA  +
Sbjct: 235 FIGNLNSTKEFDELKDALREFFSKKNLTIQDIRIGNSKKFGYVDFSSEEEV---EKALKL 291

Query: 290 CKARLDRLTNEVKSITPASEAKNKSIED-KQAEIETLTGLSSDLENKLEDLQLLVSNPK 347
              ++  L  EVK     +  KNK+ E+ K+ +  TL   +      +E+LQ +  N K
Sbjct: 292 TGKKI--LGTEVKIEKAMAFDKNKTAENKKERDSRTLFVKNIPYSTTVEELQEIFENAK 348


>RA50_HALVO (P62133) DNA double-strand break repair rad50 ATPase
          Length = 893

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 59/243 (24%), Positives = 102/243 (41%), Gaps = 27/243 (11%)

Query: 119 ALLYKAQEEADPLGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASND 178
           A L   + E D L +     E S + S +D++ KS ++AAE    A+   +AE+    ++
Sbjct: 206 ATLNALESELDSLDE-----EISNYESQRDKA-KSALDAAE----ATLDEHAEKRERLDE 255

Query: 179 QESAVDDESTKNYQEEDDEDSDAE-----DTEADEDESDLDLAWKMLDI----ARAIVEK 229
            ESA++D + K   +E   D  +E     D  ADE ESD+D A    D+      AI + 
Sbjct: 256 IESAIEDLTAKISADETKRDDLSERVRELDAAADELESDIDDALARADLDDASDEAIADA 315

Query: 230 QCVNTIEHVDILSTLAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASV 289
           +   +    ++   L+E     + FE      ++    LE   + K E A    E AA  
Sbjct: 316 REALSARESELRDDLSEARTRAQAFETQAERLRERADDLESRAEEKREAAEVDAETAAEA 375

Query: 290 CKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKST 349
                     E++S          +++D +A  E       +  + LE+ +   S  + +
Sbjct: 376 --------ERELESFRETRAELRSALDDAEARFEDAPVELGEAADLLEERREARSEARES 427

Query: 350 LSE 352
           L+E
Sbjct: 428 LAE 430



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 34/223 (15%)

Query: 145 SSKDESVKSTINAAESS--TAASFSSNAEQ--DIASNDQESAVDDESTKNYQEEDDEDSD 200
           + ++E+V+S   AAE     AA   S AE+  + A+   E A +   T +  E D +  D
Sbjct: 526 ADREETVESRREAAEEKREAAAELDSEAEEKREAATTQAERAEEVAETVDSLESDLDTLD 585

Query: 201 AEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILSTLAEISLEREEFENSLSD 260
                 D  ES +D   + +D    + EK+            TLAE++ ER E    L +
Sbjct: 586 DRRDRLDRVESLVDTRAEKIDARDRLREKR-----------ETLAEVNRERRE---HLRE 631

Query: 261 YQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDK-- 318
            ++    L + VD   EEA+   ++      A L+R+ +EV    P    K   ++ +  
Sbjct: 632 RRERRDELRETVD---EEAVEGAKQRKKNAAAYLERVEDEV---LPELREKRDDLQSRVG 685

Query: 319 --QAEIETLTGLSSDLENKLEDLQLL------VSNPKSTLSEL 353
             +AE+E L  L    ++  E +  L      VS  +ST  +L
Sbjct: 686 GVEAELEQLDDLRERRDHLAERVDALESVHDEVSTLESTYGDL 728



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 67/299 (22%), Positives = 119/299 (39%), Gaps = 43/299 (14%)

Query: 149 ESVKSTINAAESSTAASFSSNAEQDIASNDQESAVD--DESTKNYQEEDDEDS---DAED 203
           E V+S I A E         +A+     N  ES +D  DE   NY+ + D+     DA +
Sbjct: 190 EDVESQIEAKE---------DADLHATLNALESELDSLDEEISNYESQRDKAKSALDAAE 240

Query: 204 TEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILSTLAEISLEREEFENSLSDYQK 263
              DE     +   ++      +  K   +  +  D+   + E+    +E E+ + D   
Sbjct: 241 ATLDEHAEKRERLDEIESAIEDLTAKISADETKRDDLSERVRELDAAADELESDIDD--- 297

Query: 264 ALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIE 323
             ++    +D   +EAIA   +A S   AR   L +++      SEA+ ++ +  + + E
Sbjct: 298 --ALARADLDDASDEAIADAREALS---ARESELRDDL------SEARTRA-QAFETQAE 345

Query: 324 TLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKESIPAKVSSSQLATANSS 383
            L   + DLE++ E+        K   +E+  + AA+A    ES     +  + A  ++ 
Sbjct: 346 RLRERADDLESRAEE--------KREAAEVDAETAAEAERELESFRETRAELRSALDDAE 397

Query: 384 GGFDSPTISTAHSNGSAAGVTHLGVVGRGVKRTSLAPEASAPK--KPALESTEGKGDSG 440
             F+   +      G AA +       R   R SLA   +  K  +  L   E   D+G
Sbjct: 398 ARFEDAPVEL----GEAADLLEERREARSEARESLAETETELKNARERLAEAERLRDAG 452



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 65/289 (22%), Positives = 116/289 (39%), Gaps = 37/289 (12%)

Query: 66  ELAVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECVNTYYKYGCALLYKAQ 125
           EL  ++ D   +A  +D   EA  +   AL  R +   +   E       +      + +
Sbjct: 290 ELESDIDDALARADLDDASDEAIADAREALSARESELRDDLSEARTRAQAFETQA-ERLR 348

Query: 126 EEADPLGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAVDD 185
           E AD   D+  + E  +  +  D     T   AE    +   + AE   A +D E+  +D
Sbjct: 349 ERAD---DLESRAEEKREAAEVDAE---TAAEAERELESFRETRAELRSALDDAEARFED 402

Query: 186 ------ESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEK----QCVNTI 235
                 E+    +E  +  S+A ++ A E E++L  A + L  A  + +     +C   +
Sbjct: 403 APVELGEAADLLEERREARSEARESLA-ETETELKNARERLAEAERLRDAGKCPECGQPV 461

Query: 236 E---HVDILS----TLAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAAS 288
           E   HVD +S     +  +  +RE  E+++     A+   E LV+          E  AS
Sbjct: 462 EGSPHVDAISEREAAVESLEADRESLESAVESRSAAVEAAEALVE---------VETRAS 512

Query: 289 VCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLE 337
             + RLD +   +       E++ ++ E+K+   E    L S+ E K E
Sbjct: 513 SRRDRLDLVDERIADREETVESRREAAEEKR---EAAAELDSEAEEKRE 558


>NUCL_HUMAN (P19338) Nucleolin (Protein C23)
          Length = 706

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 48/210 (22%), Positives = 86/210 (40%), Gaps = 20/210 (9%)

Query: 6   PASETSVSMAPSEEAVAVDGTLNPSEHGKSEITNGATVDSAAIGGAESASNAETSGKNSL 65
           PA + +V+      A     T+ P++   +    GAT   A +          T GK   
Sbjct: 76  PAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVA---------TPGKKGA 126

Query: 66  ELAVELMDKGTKAMKEDDFGEA---AENFSRALEIRVANYGELAPECVNTYYKYGCALLY 122
            +  +    G  A KED   E    +E      E    +  E+ P  +        A   
Sbjct: 127 AIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKA-----AAAAP 181

Query: 123 KAQEEADPLGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESA 182
            +++E D   +  +  +  +   S++E++++T   A+   AA       +++A ++ E  
Sbjct: 182 ASEDEDDEDDEDDEDDDDDEEDDSEEEAMETT--PAKGKKAAKVVPVKAKNVAEDEDEEE 239

Query: 183 VDDESTKNYQEEDDEDSDAEDTEADEDESD 212
            DDE   +  +EDDED D ED E +E+E +
Sbjct: 240 -DDEDEDDDDDEDDEDDDDEDDEEEEEEEE 268


>SR40_YEAST (P32583) Suppressor protein SRP40
          Length = 406

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 42/207 (20%), Positives = 88/207 (42%), Gaps = 5/207 (2%)

Query: 7   ASETSVSMAPSEEAVAVDGTLNPSEHGKSEITNGATVDSAAIGGAESASNAETSGKNSLE 66
           + E+S S + S  + + D + + S+   S  ++ ++  S++   +ES+S +++S   S  
Sbjct: 49  SGESSSSSSSSSSSSSSDSS-DSSDSESSSSSSSSSSSSSSSSDSESSSESDSSSSGSSS 107

Query: 67  LAVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECVNTYYKYGCALLYKAQE 126
            +    D+ +   + +D  +     S   + +     +  PE  ++           ++ 
Sbjct: 108 SSSSSSDESSSESESEDETKKRARESDNEDAKETKKAKTEPESSSSSESSSSGSSSSSES 167

Query: 127 EADPLGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAVDDE 186
           E+   G        S   SS D    S  ++  SS+++S  S+++ D +S+D  S  D  
Sbjct: 168 ES---GSESDSDSSSSSSSSSDSESDSESDSQSSSSSSSSDSSSDSDSSSSDSSSDSDSS 224

Query: 187 STKNYQEED-DEDSDAEDTEADEDESD 212
           S+ +    D D DSD+         SD
Sbjct: 225 SSSSSSSSDSDSDSDSSSDSDSSGSSD 251



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 44/224 (19%), Positives = 99/224 (43%), Gaps = 18/224 (8%)

Query: 4   EAPASETSVSMAPSEEAVAVDGTLNPSEHGKSEITNGATVDSAAIGGAESASNAETSGKN 63
           E+ +S +S S + S ++     + + S    S  ++ ++ DS +   ++S+S+  +S  +
Sbjct: 51  ESSSSSSSSSSSSSSDSSDSSDSESSSSSSSSSSSSSSSSDSESSSESDSSSSGSSSSSS 110

Query: 64  SLE----LAVELMDKGTKAMKEDDFGEAAENFSRALEIRVANYGELAPECVNTYYKY--- 116
           S         E  D+  K  +E D  +A E      E   ++  E +    ++  +    
Sbjct: 111 SSSDESSSESESEDETKKRARESDNEDAKETKKAKTEPESSSSSESSSSGSSSSSESESG 170

Query: 117 -------GCALLYKAQEEADPLGDVPKKQEGSQHGSSKDESVKSTINAAES---STAASF 166
                    +    +  E+D   D       S   SS D    S+ ++++S   S+++S 
Sbjct: 171 SESDSDSSSSSSSSSDSESDSESDSQSSSSSSSSDSSSDSDSSSSDSSSDSDSSSSSSSS 230

Query: 167 SSNAEQDI-ASNDQESAVDDESTKNYQEEDDEDSDAEDTEADED 209
           SS+++ D  +S+D +S+   +S+ +     DE + ++ +++D D
Sbjct: 231 SSDSDSDSDSSSDSDSSGSSDSSSSSDSSSDESTSSDSSDSDSD 274



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 60/309 (19%), Positives = 116/309 (37%), Gaps = 19/309 (6%)

Query: 136 KKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAVDDESTKNYQEED 195
           K    S   SS   S  S+ +++ SS  +S SS++    +S+D   + D ES+ +     
Sbjct: 24  KSSSSSSSSSSSSSSSSSSSSSSSSSGESSSSSSSSSSSSSSDSSDSSDSESSSSSSSSS 83

Query: 196 DEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILSTLAEISLEREEFE 255
              S + D+E+   ESD   +      + +  E    +  E         E      E +
Sbjct: 84  SSSSSSSDSES-SSESDSSSSGSSSSSSSSSDESSSESESED--------ETKKRARESD 134

Query: 256 NSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSI 315
           N  +   K          ++PE + +  E ++S   +  +  +        +S + + S 
Sbjct: 135 NEDAKETKK-------AKTEPESS-SSSESSSSGSSSSSESESGSESDSDSSSSSSSSSD 186

Query: 316 EDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKESIPAKVSSS 375
            +  +E ++ +  SS   +   D     S+  S         ++ +    +S  +  S S
Sbjct: 187 SESDSESDSQSSSSSSSSDSSSDSDSSSSDSSSDSDSSSSSSSSSSDSDSDSDSSSDSDS 246

Query: 376 QLATANSSGGFDSPTISTAHSNGSAAGVTHLGVVGRGVKRTSLAPEASAPKKPAL--EST 433
             ++ +SS    S   ST+  +  +   +  G       + + A E+ A + PA   EST
Sbjct: 247 SGSSDSSSSSDSSSDESTSSDSSDSDSDSDSGSSSELETKEATADESKAEETPASSNEST 306

Query: 434 EGKGDSGSA 442
                S SA
Sbjct: 307 PSASSSSSA 315



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 21/96 (21%), Positives = 42/96 (42%)

Query: 306 PASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGK 365
           P    K K IE+K +   + +  SS   +             S+ S      ++ +    
Sbjct: 12  PKLSVKEKEIEEKSSSSSSSSSSSSSSSSSSSSSSSSSGESSSSSSSSSSSSSSDSSDSS 71

Query: 366 ESIPAKVSSSQLATANSSGGFDSPTISTAHSNGSAA 401
           +S  +  SSS  ++++SS   +S + S + S+GS++
Sbjct: 72  DSESSSSSSSSSSSSSSSSDSESSSESDSSSSGSSS 107


>TPM3_MOUSE (P21107) Tropomyosin alpha 3 chain (Tropomyosin 3)
           (Tropomyosin gamma)
          Length = 284

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 51/241 (21%), Positives = 109/241 (45%), Gaps = 15/241 (6%)

Query: 123 KAQEEADPLGDVPKKQEGSQHGSSK-DESVKSTINAAESSTAASFSSNAEQDIAS-NDQE 180
           ++++  D L  + KK +G++    K  E++K      E   A   +++AE ++AS N + 
Sbjct: 35  RSKQLEDELATMQKKLKGTEDELDKYSEALKDAQEKLE--LAEKKAADAEAEVASLNRRI 92

Query: 181 SAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDI 240
             V++E  +  +         E+ E   DES+  +          ++E + +   E +++
Sbjct: 93  QLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIENRALKDEEKMEL 143

Query: 241 LST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTN 299
               L E     EE +    +  + L I+E  ++ + EE     E   S  +  L  +TN
Sbjct: 144 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE-RTEERAELAESKCSELEEELKNVTN 202

Query: 300 EVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAA 359
            +KS+   +E  ++  +  + EI+ LT    + E + E  +  V+  + T+ +L +++ A
Sbjct: 203 NLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYA 262

Query: 360 K 360
           +
Sbjct: 263 Q 263


>TPM1_RANTE (P13105) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
          Length = 284

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 51/241 (21%), Positives = 109/241 (45%), Gaps = 15/241 (6%)

Query: 123 KAQEEADPLGDVPKKQEGSQHGSSK-DESVKSTINAAESSTAASFSSNAEQDIAS-NDQE 180
           K+++  D L  + KK +G++    K  E++K      E   A   +++AE D+AS N + 
Sbjct: 35  KSKQLEDELVAMQKKMKGTEDELDKYSEALKDAQEKLE--LAEKKATDAEADVASLNRRI 92

Query: 181 SAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDI 240
             V++E  +  +         E+ E   DES+  +          ++E + +   E +++
Sbjct: 93  QLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIENRALKDEEKIEL 143

Query: 241 LST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTN 299
               L E     EE +    +  + L I+E  ++ + EE     E   +  +  L  +TN
Sbjct: 144 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE-RAEERAELSESKCAELEEELKTVTN 202

Query: 300 EVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAA 359
            +KS+   +E  ++  +  + EI+ LT    + E + E  +  V+  + ++ +L +++ A
Sbjct: 203 NLKSLEAQAEKYSQKEDKYEEEIKVLTDKLKEAETRAEFAERTVAKLEKSIDDLEDELYA 262

Query: 360 K 360
           +
Sbjct: 263 Q 263


>TPM3_HUMAN (P06753) Tropomyosin alpha 3 chain (Tropomyosin 3)
           (Tropomyosin gamma) (hTM5)
          Length = 284

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 51/241 (21%), Positives = 109/241 (45%), Gaps = 15/241 (6%)

Query: 123 KAQEEADPLGDVPKKQEGSQHGSSK-DESVKSTINAAESSTAASFSSNAEQDIAS-NDQE 180
           ++++  D L  + KK +G++    K  E++K      E   A   +++AE ++AS N + 
Sbjct: 35  RSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLE--LAEKKAADAEAEVASLNRRI 92

Query: 181 SAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDI 240
             V++E  +  +         E+ E   DES+  +          ++E + +   E +++
Sbjct: 93  QLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIENRALKDEEKMEL 143

Query: 241 LST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTN 299
               L E     EE +    +  + L I+E  ++ + EE     E   S  +  L  +TN
Sbjct: 144 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE-RTEERAELAESKCSELEEELKNVTN 202

Query: 300 EVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAA 359
            +KS+   +E  ++  +  + EI+ LT    + E + E  +  V+  + T+ +L +++ A
Sbjct: 203 NLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYA 262

Query: 360 K 360
           +
Sbjct: 263 Q 263


>EP15_MOUSE (P42567) Epidermal growth factor receptor substrate 15
           (Protein Eps15) (AF-1p protein)
          Length = 897

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 55/235 (23%), Positives = 96/235 (40%), Gaps = 23/235 (9%)

Query: 156 NAAESSTAASFSSNAEQDIASNDQESAVDDESTKNYQEED---DEDSDAEDTEADEDESD 212
           N   SS  A FS+  E D  +N+    VD +  KN  E+D    ED+  + T   +D  D
Sbjct: 319 NITGSSPVADFSAIKELDTLNNE---IVDLQREKNNVEQDLKEKEDTVKQRTSEVQDLQD 375

Query: 213 LDLAWKMLDIARAIVEKQCVNTIEHVDILSTLAEISLEREEFENSLSDYQKALSILEQLV 272
            ++  + +++ +   +KQ V  +        L E+  ++ + E  L + +K  +   QL+
Sbjct: 376 -EVQRESINLQKLQAQKQQVQEL--------LGELDEQKAQLEEQLQEVRKKCAEEAQLI 426

Query: 273 DS------KPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLT 326
            S        E  I+  E+     +  L RL  E   +  + E+    +E  Q  ++   
Sbjct: 427 SSLKAEITSQESQISSYEEELLKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQESQ 486

Query: 327 GLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGGGKESIPAKVSSSQLATAN 381
              S ++ +LE   L   N +S  S   + V     G  +      SSS+ A  N
Sbjct: 487 QEISSMQMRLEMKDLETDNNQSNWSSSPQSVL--VNGATDYCSLSTSSSETANFN 539


>TPM4_RAT (P09495) Tropomyosin alpha 4 chain (Tropomyosin 4) (TM-4)
          Length = 248

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 47/191 (24%), Positives = 86/191 (44%), Gaps = 12/191 (6%)

Query: 170 AEQDIAS-NDQESAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVE 228
           AE D A+ N +   V++E  +  +         E+ E   DES+  +          ++E
Sbjct: 45  AEGDAAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIE 95

Query: 229 KQCVNTIEHVDILST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAA 287
            + +   E ++I    L E     EE +    +  + L ILE  ++ + EE     E  +
Sbjct: 96  NRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELE-RAEERAEVSELKS 154

Query: 288 SVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPK 347
           S  +  L  +TN +KS+  ASE  ++  +  + EI+ L+    + E + E  +  VS  +
Sbjct: 155 SDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLE 214

Query: 348 STLSELLEKVA 358
            T+ +L EK+A
Sbjct: 215 KTIDDLEEKLA 225


>TPM1_XENLA (Q01173) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
          Length = 284

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 51/241 (21%), Positives = 109/241 (45%), Gaps = 15/241 (6%)

Query: 123 KAQEEADPLGDVPKKQEGSQHGSSK-DESVKSTINAAESSTAASFSSNAEQDIAS-NDQE 180
           K+++  D L  + KK +G++    K  E++K      E S   +  ++AE D+AS N + 
Sbjct: 35  KSKQLEDELVALQKKLKGTEDELDKYSEALKDAQEKLELSDKKA--TDAEGDVASLNRRI 92

Query: 181 SAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDI 240
             V++E  +  +         E+ E   DES+  +          ++E + +   E +++
Sbjct: 93  QLVEEELDRAQERLSTALQKLEEAEKAADESERGMK---------VIENRALKDEEKMEL 143

Query: 241 LST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTN 299
               L E     EE +    +  + L I+E  ++ + EE     E   +  +  L  +TN
Sbjct: 144 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE-RAEERAELSESKCAELEEELKTVTN 202

Query: 300 EVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAA 359
            +KS+   +E  ++  +  + EI+ LT    + E + E  +  V+  + ++ +L +++ A
Sbjct: 203 NLKSLEAQAEKYSQKEDKYEEEIKVLTDKLKEAETRAEFAERTVAKLEKSIDDLEDELYA 262

Query: 360 K 360
           +
Sbjct: 263 Q 263


>DMP1_HUMAN (Q13316) Dentin matrix acidic phosphoprotein 1 precursor
           (Dentin matrix protein-1) (DMP-1)
          Length = 513

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 69/304 (22%), Positives = 121/304 (39%), Gaps = 44/304 (14%)

Query: 30  SEHGKSEITNGATVDSAAIGGAESASNAETSGKNSLELAVELMDKGTKAMKEDDFGEAAE 89
           SE G S + +       +   +E A+  ++ G   LE     + + ++  +EDD  E  +
Sbjct: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284

Query: 90  NFSRALEIRVANYGELAPECVNTYYKYGCALLYKAQEEADPLGDVPKKQEGSQHGSSKDE 149
           N +           E+  +           L   +Q   D  GD    QE S+   S++E
Sbjct: 285 NNTME---------EVKSDSTENSNSRDTGL---SQPRRDSKGD---SQEDSKENLSQEE 329

Query: 150 SVKSTINAAESSTAASFSSNAEQDIASNDQESAVD-------DESTKNYQEEDDEDSDAE 202
           S      ++ESS  A+ SS   Q+ +S  QE  V        D +T   ++++D DS  E
Sbjct: 330 SQNVDGPSSESSQEANLSS---QENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE 386

Query: 203 DTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILSTLAEISLEREEFENSLSDYQ 262
           D+      S  +   +  D        + +N           +E S E  E ENS S  Q
Sbjct: 387 DSSHTLSHSKSESREEQADSE----SSESLN----------FSEESPESPEDENSSS--Q 430

Query: 263 KALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASE---AKNKSIEDKQ 319
           + L       +S+ EE+ +  + + S   +R    +N  +S + + E    KN  IE ++
Sbjct: 431 EGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 490

Query: 320 AEIE 323
             ++
Sbjct: 491 LTVD 494



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 32/97 (32%), Positives = 40/97 (40%), Gaps = 15/97 (15%)

Query: 129 DPLGDVPK-KQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASN----DQESAV 183
           D  G  PK +QEG       DE    TI A+E S  A    ++ QD  S     D E  V
Sbjct: 117 DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEES--APQGQDSAQDTTSESRELDNEDRV 174

Query: 184 DD--ESTKNYQEEDDED------SDAEDTEADEDESD 212
           D   E   + QE + E+      SD E +  D  E D
Sbjct: 175 DSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELD 211


>TPM4_MOUSE (Q6IRU2) Tropomyosin alpha 4 chain (Tropomyosin 4)
          Length = 248

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 46/191 (24%), Positives = 85/191 (44%), Gaps = 12/191 (6%)

Query: 170 AEQDIASNDQESAVDDESTKNYQEE-DDEDSDAEDTEADEDESDLDLAWKMLDIARAIVE 228
           AE D A+ ++   + +E     QE+      + E+ E   DES+  +          ++E
Sbjct: 45  AEGDAAALNRRIQLLEEELDRAQEQLATALQNLEEAEKAADESERGMK---------VIE 95

Query: 229 KQCVNTIEHVDILST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAA 287
            + +   E ++IL   L E     +E +    +  + L ILE  +  + EE     E   
Sbjct: 96  NRAMKDEEKMEILEMQLKEAKHITDEADRKYEEVARKLVILEGEL-KRAEERAEVSELKC 154

Query: 288 SVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPK 347
              +  L  +TN +KS+  ASE  ++  +  + EI+ L+    + E + E  +  VS  +
Sbjct: 155 GDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLE 214

Query: 348 STLSELLEKVA 358
            T+ +L EK+A
Sbjct: 215 KTIDDLEEKLA 225


>SMC2_XENLA (P50533) Structural maintenance of chromosome 2
           (Chromosome-associated protein E) (Chromosome assembly
           protein XCAP-E)
          Length = 1203

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 57/236 (24%), Positives = 102/236 (43%), Gaps = 30/236 (12%)

Query: 126 EEADPLGDVPKKQEGSQHGSSKD-ESVKSTINAAESSTAASFSSNAEQDIASNDQESAVD 184
           EEA+ L    K Q+ S H   ++ +S+K TI  +E +       N ++     +++  V 
Sbjct: 725 EEAELLQT--KLQQSSYHKQQEELDSLKQTIEESEETL-----KNTKEVQKKAEEKFKVL 777

Query: 185 DESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIA-RAIVEKQCVNTIEHVDILST 243
           +   KN + E        + E  E +  LD A K  D + + + EKQ     + VD L  
Sbjct: 778 EHKMKNAEAE-------RERELKEAQQKLDTAKKKADASNKKMKEKQ-----QEVDALVL 825

Query: 244 -LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVK 302
            L E+  E+  ++  +    +A+   ++  DS   E      K     K   D L  + +
Sbjct: 826 ELEELKREQTTYKQQIETVDEAMKAYQEQADSMASEV----SKNKEAVKKAQDELAKQKE 881

Query: 303 SITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVA 358
            I       +K I+ K +E   L   ++DL+ K+++L+  +S  K   ++   KVA
Sbjct: 882 IIM----GHDKEIKTKSSEAGKLRENNNDLQLKIKELEHNISKHKKDSADAAAKVA 933


>MYH6_MESAU (P13539) Myosin heavy chain, cardiac muscle alpha isoform
            (MyHC-alpha)
          Length = 1939

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 52/239 (21%), Positives = 105/239 (43%), Gaps = 39/239 (16%)

Query: 129  DPLGDVPKKQEGSQHGSSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAVDDEST 188
            +  G V +  E S+  + + E  +  ++  +      F   AEQD  ++ +E    D+  
Sbjct: 856  EEFGRVKESLEKSE--ARRKELEEKMVSLLQEKNDLQFQVQAEQDNLNDAEERC--DQLI 911

Query: 189  KNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVEKQCVNTIEHVDILS-TLAEI 247
            KN  + + +  +  +   DE+E + +L  K     +  +E +C    + +D L  TLA++
Sbjct: 912  KNKIQLEAKVKEMTERLEDEEEMNAELTSK-----KRKLEDECSELKKDIDDLELTLAKV 966

Query: 248  SLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPA 307
              E+   EN + +  + ++ L++++                       +LT E K++   
Sbjct: 967  EKEKHATENKVKNLTEEMAGLDEIIA----------------------KLTKEKKAL--- 1001

Query: 308  SEAKNKSIEDKQAE---IETLTGLSSDLENKLEDLQLLVSNPKSTLSELLEKVAAKAGG 363
             EA  ++++D QAE   + TLT     LE +++DL+  +   K    + LE+   K  G
Sbjct: 1002 QEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMD-LERAKRKLEG 1059



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 46/245 (18%), Positives = 103/245 (41%), Gaps = 19/245 (7%)

Query: 145  SSKDESVKSTINAAESSTAASFSSNAEQDIASNDQESAVDDESTKNYQEEDDEDSDAEDT 204
            S+ ++ +K+  N  + S      +N E  +   + + +++D +T+  + + +    A   
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQAN-EYRVKLEESQRSLNDFTTQRAKLQTENGELARQL 1293

Query: 205  EADE------DESDLDLAWKMLDIARAIVEK-QCVNTIEHVDILSTLAEISLEREEFENS 257
            E  E          L    +M D+ R + E+ +  N + H  + S   +  L RE++E  
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA-LQSARHDCDLLREQYEEE 1352

Query: 258  LSDYQKALSILEQLVDSKPEEAIAYCEKAASVCKARLDRLTNEVKSITPASEAKNKSIED 317
            +    +A + L++++     E   +  K  +    R + L    K +    +   +++E 
Sbjct: 1353 M----EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408

Query: 318  KQAEIETLTGLSSDLENKLEDLQLLVSNPKSTLSEL------LEKVAAKAGGGKESIPAK 371
              A+  +L      L+N++EDL + V    +  + L       +K+ A+     E   ++
Sbjct: 1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1468

Query: 372  VSSSQ 376
            + SSQ
Sbjct: 1469 LESSQ 1473


>TPM4_PIG (P67937) Tropomyosin alpha 4 chain (Tropomyosin 4)
          Length = 248

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 45/191 (23%), Positives = 85/191 (43%), Gaps = 12/191 (6%)

Query: 170 AEQDIAS-NDQESAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVE 228
           AE D+A+ N +   V++E  +  +         E+ E   DES+  +          ++E
Sbjct: 45  AEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIE 95

Query: 229 KQCVNTIEHVDILST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAA 287
            + +   E ++I    L E     EE +    +  + L ILE  ++ + EE     E   
Sbjct: 96  NRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELE-RAEERAEVSELKC 154

Query: 288 SVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPK 347
              +  L  +TN +KS+  ASE  ++  +  + EI+ L+    + E + E  +  V+  +
Sbjct: 155 GDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE 214

Query: 348 STLSELLEKVA 358
            T+ +L EK+A
Sbjct: 215 KTIDDLEEKLA 225


>TPM4_HUMAN (P67936) Tropomyosin alpha 4 chain (Tropomyosin 4)
           (TM30p1)
          Length = 248

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 45/191 (23%), Positives = 85/191 (43%), Gaps = 12/191 (6%)

Query: 170 AEQDIAS-NDQESAVDDESTKNYQEEDDEDSDAEDTEADEDESDLDLAWKMLDIARAIVE 228
           AE D+A+ N +   V++E  +  +         E+ E   DES+  +          ++E
Sbjct: 45  AEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMK---------VIE 95

Query: 229 KQCVNTIEHVDILST-LAEISLEREEFENSLSDYQKALSILEQLVDSKPEEAIAYCEKAA 287
            + +   E ++I    L E     EE +    +  + L ILE  ++ + EE     E   
Sbjct: 96  NRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELE-RAEERAEVSELKC 154

Query: 288 SVCKARLDRLTNEVKSITPASEAKNKSIEDKQAEIETLTGLSSDLENKLEDLQLLVSNPK 347
              +  L  +TN +KS+  ASE  ++  +  + EI+ L+    + E + E  +  V+  +
Sbjct: 155 GDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE 214

Query: 348 STLSELLEKVA 358
            T+ +L EK+A
Sbjct: 215 KTIDDLEEKLA 225


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.301    0.120    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,845,412
Number of Sequences: 164201
Number of extensions: 1954169
Number of successful extensions: 18180
Number of sequences better than 10.0: 1007
Number of HSP's better than 10.0 without gapping: 329
Number of HSP's successfully gapped in prelim test: 704
Number of HSP's that attempted gapping in prelim test: 11497
Number of HSP's gapped (non-prelim): 3413
length of query: 442
length of database: 59,974,054
effective HSP length: 113
effective length of query: 329
effective length of database: 41,419,341
effective search space: 13626963189
effective search space used: 13626963189
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 67 (30.4 bits)