BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0544.5
(471 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
GTR8_MOUSE (Q9JIF3) Solute carrier family 2, facilitated glucose... 244 5e-64
GTR8_HUMAN (Q9NY64) Solute carrier family 2, facilitated glucose... 243 1e-63
GTR8_RAT (Q9JJZ1) Solute carrier family 2, facilitated glucose t... 237 4e-62
GTR6_HUMAN (Q9UGQ3) Solute carrier family 2, facilitated glucose... 225 2e-58
GTR4_RAT (P19357) Solute carrier family 2, facilitated glucose t... 223 6e-58
GTR4_MOUSE (P14142) Solute carrier family 2, facilitated glucose... 223 1e-57
GTR3_RAT (Q07647) Solute carrier family 2, facilitated glucose t... 222 1e-57
XYLT_LACBR (O52733) D-xylose-proton symporter (D-xylose transpor... 221 3e-57
CSBC_BACSU (P46333) Probable metabolite transport protein csbC 218 3e-56
GTR4_HUMAN (P14672) Solute carrier family 2, facilitated glucose... 218 3e-56
GTR3_MOUSE (P32037) Solute carrier family 2, facilitated glucose... 216 1e-55
ITR2_YEAST (P30606) Myo-inositol transporter 2 215 2e-55
GTR2_HUMAN (P11168) Solute carrier family 2, facilitated glucose... 214 3e-55
YFIG_BACSU (P54723) Hypothetical metabolite transport protein yfiG 213 9e-55
GTR4_BOVIN (Q27994) Solute carrier family 2, facilitated glucose... 212 1e-54
GTR2_RAT (P12336) Solute carrier family 2, facilitated glucose t... 209 2e-53
GTR2_MOUSE (P14246) Solute carrier family 2, facilitated glucose... 208 2e-53
ITR1_YEAST (P30605) Myo-inositol transporter 1 208 3e-53
GTR3_CANFA (P47842) Solute carrier family 2, facilitated glucose... 207 5e-53
GTR2_CHICK (Q90592) Solute carrier family 2, facilitated glucose... 204 3e-52
>GTR8_MOUSE (Q9JIF3) Solute carrier family 2, facilitated glucose
transporter, member 8 (Glucose transporter type 8)
(Glucose transporter type X1)
Length = 477
Score = 244 bits (622), Expect = 5e-64
Identities = 153/456 (33%), Positives = 251/456 (54%), Gaps = 37/456 (8%)
Query: 31 LSTLVAVLGSYAFGAAIGYSSPTQSAIM----PDLNLTVAQFSIFGSILTIGAMIGAIVS 86
L++ A LG +FG A+GYSSP ++ P L L S FG+++T+GA G I+
Sbjct: 28 LASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILG 87
Query: 87 GKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAE 146
G + D +GR++++ + + G+ VIT ++ W L GRLL G G+ S V PVY++E
Sbjct: 88 GWLLDRSGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISE 147
Query: 147 ITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPR 206
I +RG + QLM+ G+ L Y+ G + WR LA++G +P LL + ++P++PR
Sbjct: 148 IAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPR 207
Query: 207 WLAKVGHLKESDSALQRLRGKNADVHQE--AAEIRDYTETLQRQTEASIIGLFQWKYMTS 264
+L +E+ +AL+ L G + AE + + L R+ G+++
Sbjct: 208 FLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLALLRRP-----GIYK-----P 257
Query: 265 LTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKS 323
L IG+ LM+ QQ G+N I+FYANSIF A F + S+ ++ + +++ T + L+MD++
Sbjct: 258 LIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRA 317
Query: 324 GRRPLLLLSA-----AGTCLGCFLAALAFLLQGLHEWKGVSPI-------------LALV 365
GRR LL LS + + G + L L G+ PI LA+
Sbjct: 318 GRRLLLALSGVIMVFSMSAFGTYF-KLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVG 376
Query: 366 GVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSW-S 424
+ +++ +++G G IPW++MSEIFP++VKG A + NW +++V+ F+ +M
Sbjct: 377 SMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLR 436
Query: 425 STGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQA 460
G F++ ++ C +VLF +VPETKGRTLE++ A
Sbjct: 437 PYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTA 472
>GTR8_HUMAN (Q9NY64) Solute carrier family 2, facilitated glucose
transporter, member 8 (Glucose transporter type 8)
(Glucose transporter type X1)
Length = 477
Score = 243 bits (619), Expect = 1e-63
Identities = 159/456 (34%), Positives = 245/456 (52%), Gaps = 37/456 (8%)
Query: 31 LSTLVAVLGSYAFGAAIGYSSPT----QSAIMPDLNLTVAQFSIFGSILTIGAMIGAIVS 86
L+ A LG +FG A+GYSSP Q A P L A S FG+++T+GA G ++
Sbjct: 28 LAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLG 87
Query: 87 GKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAE 146
G + D AGR++++ + + G+ VIT ++ W L GRLL G G+ S V PVY++E
Sbjct: 88 GWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISE 147
Query: 147 ITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPR 206
I +RG + QLM+ G+ L YL G + WR LA++G +P LL + F+P++PR
Sbjct: 148 IAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPR 207
Query: 207 WLAKVGHLKESDSALQRLRGKNADVHQE--AAEIRDYTETLQRQTEASIIGLFQWKYMTS 264
+L +E+ +AL+ L G AE + + L RQ G+++
Sbjct: 208 FLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE-QSFHLALLRQP-----GIYK-----P 256
Query: 265 LTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKS 323
IGV LM QQ G+N ++FYA +IF A F + S+ ++ + +++ T + L+MD++
Sbjct: 257 FIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRA 316
Query: 324 GRRPLLLLSAAGTCLGCFLAALAF-LLQG---------LHEWKGVSPILALVG------- 366
GRR LL+LS F L QG + P+ A VG
Sbjct: 317 GRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVG 376
Query: 367 -VLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMS-WS 424
+ +++ +++G G IPW++MSEIFP++VKG A + NWL +++V+ F+ LM
Sbjct: 377 SMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLR 436
Query: 425 STGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQA 460
G F++ S+ C F+VLF VPETKG+TLE+I A
Sbjct: 437 PYGAFWLASAFCIFSVLFTFSCVPETKGKTLEQITA 472
>GTR8_RAT (Q9JJZ1) Solute carrier family 2, facilitated glucose
transporter, member 8 (Glucose transporter type 8)
(Glucose transporter type X1)
Length = 478
Score = 237 bits (605), Expect = 4e-62
Identities = 150/456 (32%), Positives = 241/456 (51%), Gaps = 36/456 (7%)
Query: 31 LSTLVAVLGSYAFGAAIGYSSPTQSAIM----PDLNLTVAQFSIFGSILTIGAMIGAIVS 86
L+T A LG +FG A+GYSSP ++ P L L S FG+++T+GA G ++
Sbjct: 28 LATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLG 87
Query: 87 GKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAE 146
G + D AGR++++ + + G+ VIT ++ W L GRLL G G+ S V PVY++E
Sbjct: 88 GWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISE 147
Query: 147 ITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPR 206
I +RG + QLM+ G+ L Y+ G + WR LA++G +P LL + ++P++PR
Sbjct: 148 IAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPR 207
Query: 207 WLAKVGHLKESDSALQRLRGKNADVHQE--AAEIRDYTETLQRQTEASIIGLFQWKYMTS 264
+L +E+ +AL+ L G + AE + + + R+
Sbjct: 208 FLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVH----------KP 257
Query: 265 LTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKS 323
L IG+ LM+ QQ G+N I+FYAN+IF A F + S+ ++ + +++ T + L+MD++
Sbjct: 258 LIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRA 317
Query: 324 GRRPLLLLSAAGTCLGCFLAALAFLLQ----------GLHEWKGVSPI--------LALV 365
GR+ LL LS F L GL P LA+
Sbjct: 318 GRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVG 377
Query: 366 GVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMS-WS 424
+ +++ +++G G IPW++MSEIFP+++KG A + NW +++V+ FN +M
Sbjct: 378 SMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILR 437
Query: 425 STGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQA 460
G F++ ++ C +VLF VPETKGRTLE+I A
Sbjct: 438 PYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITA 473
>GTR6_HUMAN (Q9UGQ3) Solute carrier family 2, facilitated glucose
transporter, member 6 (Glucose transporter type 6)
(Glucose transporter type 9)
Length = 507
Score = 225 bits (574), Expect = 2e-58
Identities = 146/459 (31%), Positives = 241/459 (51%), Gaps = 31/459 (6%)
Query: 31 LSTLVAVLGSYAFGAAIGYSSPT----QSAIMPDLNLTVAQFSIFGSILTIGAMIGAIVS 86
L+T AVLG+++FG A+ Y+SP + ++ PDL+LT +Q S FGS+ T+GA G + +
Sbjct: 40 LATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSA 99
Query: 87 GKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAE 146
+ D GR++++ FS + G+ ++ + W L +GR L G GL + +PVYV+E
Sbjct: 100 MILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSE 159
Query: 147 ITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPR 206
I P +RG QLM G Y +G + WR LA+ G P +L L F+P+SPR
Sbjct: 160 IAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPR 219
Query: 207 WLAKVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLFQWKYMTSLT 266
+L G +E+ AL LRG + DVH E +I+D ++ + S +T
Sbjct: 220 FLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQD--NVRRQSSRVSWAEARAPHVCRPIT 277
Query: 267 IGVGLMILQQFGGINGIVFYANSIFVSAG--FSESIGTIAMVAVKIPVTVLGVLLMDKSG 324
+ + + +LQQ GI I+ Y SIF S + AV++ ++ L MD +G
Sbjct: 278 VALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAG 337
Query: 325 RRPLLLLS-----AAGTCLGCFL-----------------AALAFLLQGLHEWKGVSPIL 362
R+ LL +S AA LG ++ + L Q L G ++
Sbjct: 338 RKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLV 397
Query: 363 ALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMS 422
L+ ++++ Y++G G I W++MSE+ P+ +G A L +WL +++++ +F ++S
Sbjct: 398 PLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVS 457
Query: 423 -WSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQA 460
+ FF F++IC +++F VPETKGR+LE+I++
Sbjct: 458 TFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIES 496
>GTR4_RAT (P19357) Solute carrier family 2, facilitated glucose
transporter, member 4 (Glucose transporter type 4,
insulin-responsive)
Length = 509
Score = 223 bits (569), Expect = 6e-58
Identities = 156/476 (32%), Positives = 244/476 (50%), Gaps = 35/476 (7%)
Query: 16 DEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLT----------- 64
D E QQR T TL L+ AVLGS FG IG + Q I N T
Sbjct: 12 DGEPPQQR-VTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPD 70
Query: 65 -------VAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSK 117
+++ +I ++G MI + + G ++ + GR+ AM + + +LG ++ +
Sbjct: 71 SIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAN 130
Query: 118 VAWW---LYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCG------M 168
A L +GR L+G GL S +VP+YV EI P +LRG T++QL I G +
Sbjct: 131 AAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVL 190
Query: 169 SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLK-ESDSALQRLRGK 227
L ++G W +L I +P QLL LPF P+SPR+L + +L+ + +L+RL G
Sbjct: 191 GLESMLGTATLWPLLLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGW 250
Query: 228 NADVHQEAAEIRDYTETLQRQTEASIIGLFQWK-YMTSLTIGVGLMILQQFGGINGIVFY 286
ADV AE++D L+R+ S++ L + + L I V L + QQ GIN + +Y
Sbjct: 251 -ADVSDALAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYY 309
Query: 287 ANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAAL 345
+ SIF AG + + TI V T++ VLL++++GRR L LL AG C L +
Sbjct: 310 STSIFELAGVEQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTV 369
Query: 346 AFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFF 405
A LL L +S + ++V + +V + +G G IPW I++E+F + +A ++ F
Sbjct: 370 ALLL--LERVPSMSYV-SIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFS 426
Query: 406 NWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQAS 461
NW C++IV F ++ F +F+ + +F VPET+GRT ++I A+
Sbjct: 427 NWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAT 482
>GTR4_MOUSE (P14142) Solute carrier family 2, facilitated glucose
transporter, member 4 (Glucose transporter type 4,
insulin-responsive) (GT2)
Length = 509
Score = 223 bits (567), Expect = 1e-57
Identities = 155/477 (32%), Positives = 247/477 (51%), Gaps = 35/477 (7%)
Query: 15 NDEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLT---------- 64
+D E +QR T TL L+ AVLGS FG IG + Q I N T
Sbjct: 11 DDGEPPRQR-VTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGP 69
Query: 65 --------VAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFS 116
+++ +I ++G MI + + G ++ + GR+ AM + + +LG ++ +
Sbjct: 70 DSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLA 129
Query: 117 K-VAWW--LYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCG------ 167
VA + L +GR L+G GL S +VP+YV EI P +LRG T++QL I G
Sbjct: 130 NAVASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQV 189
Query: 168 MSLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLK-ESDSALQRLRG 226
+ L ++G W +L + +P QL+ LPF P+SPR+L + +L+ + +L+RL G
Sbjct: 190 LGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTG 249
Query: 227 KNADVHQEAAEIRDYTETLQRQTEASIIGLFQWK-YMTSLTIGVGLMILQQFGGINGIVF 285
ADV AE++D L+R+ S++ L + + L I V L + QQ GIN + +
Sbjct: 250 W-ADVSDALAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFY 308
Query: 286 YANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAA 344
Y+ SIF SAG + + TI V T++ VLL++++GRR L LL AG C GC +
Sbjct: 309 YSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMC-GCAILM 367
Query: 345 LAFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTF 404
LL L E +++V + +V + +G G IPW I++E+F + +A ++ F
Sbjct: 368 TVALL--LLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 425
Query: 405 FNWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQAS 461
NW C++IV F ++ F +F+ + +F VPET+GRT ++I A+
Sbjct: 426 SNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAA 482
>GTR3_RAT (Q07647) Solute carrier family 2, facilitated glucose
transporter, member 3 (Glucose transporter type 3,
brain)
Length = 493
Score = 222 bits (566), Expect = 1e-57
Identities = 152/473 (32%), Positives = 247/473 (52%), Gaps = 36/473 (7%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLTVAQ--------------FSIF 71
T +L + VA +GS+ FG G + ++ I LN T+ + +S+
Sbjct: 7 TPSLVFAVTVATIGSFQFGYNTGVINAPETIIKDFLNYTLEERLEDLPREGLLTTLWSLC 66
Query: 72 GSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVAW---WLYVGRLL 128
+I ++G MIG+ G + GRR +M L ILG ++ F+K+A L +GRL+
Sbjct: 67 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLIAILGGCLMGFAKIAESVEMLILGRLI 126
Query: 129 VGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCGM------SLTYLIGAFVNWRI 182
+G GL + VP+Y+ E++P LRG F T++QL I G+ L +++G+ W
Sbjct: 127 IGIFCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQVFGLDFILGSEELWPG 186
Query: 183 LALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLKESDSA---LQRLRGKNADVHQEAAEIR 239
L + IP Q +LPF P+SPR+L + + KE D A LQRL G DV QE E++
Sbjct: 187 LLGLTIIPAILQSAALPFCPESPRFL--LINRKEEDQATEILQRLWG-TPDVIQEIQEMK 243
Query: 240 DYTETLQRQTEASIIGLFQW-KYMTSLTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE 298
D + + ++ + +++ LF+ Y L I V L + QQF GIN + +Y+ IF AG E
Sbjct: 244 DESIRMSQEKQVTVLELFKSPSYFQPLLISVVLQLSQQFSGINAVFYYSTGIFQDAGVQE 303
Query: 299 SI-GTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALAFLLQGLHEWKG 357
I TI V TV+ + L++++GRR L ++ G + ++ LL+ +E
Sbjct: 304 PIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSVFMTISLLLKDEYE--- 360
Query: 358 VSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAF 417
+ +V +LVYV + +G G IPW I++E+F + +A ++ NW +++V F
Sbjct: 361 AMSFVCIVAILVYVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGMFF 420
Query: 418 NFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQASL--SSHSTK 468
++ F IF++ F ++F + VPETKGRT E+I + +HS K
Sbjct: 421 PSAAAYLGAYVFIIFAAFLVFFLIFTSFKVPETKGRTFEDITRAFEGQAHSGK 473
>XYLT_LACBR (O52733) D-xylose-proton symporter (D-xylose
transporter)
Length = 457
Score = 221 bits (563), Expect = 3e-57
Identities = 137/437 (31%), Positives = 223/437 (50%), Gaps = 21/437 (4%)
Query: 38 LGSYAFGAAIGYSSPTQSAIMPDLNLTVAQFSIFGSILTIGAMIGAIVSGKVADYAGRRV 97
LG FG G S I +NL Q S + +GA++GA + G +D GRR
Sbjct: 15 LGGLLFGYDTGVISGAILFIQKQMNLGSWQQGWVVSAVLLGAILGAAIIGPSSDRFGRRK 74
Query: 98 AMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFT 157
+ S + +G L FS W L + R+++G +G S ++P Y+AE+ P + RG +
Sbjct: 75 LLLLSAIIFFVGALGSAFSPEFWTLIISRIILGMAVGAASALIPTYLAELAPSDKRGTVS 134
Query: 158 TMHQLMICCGMSLTYLI-----GAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVG 212
++ QLM+ G+ L Y+ G + WR + AIP L +P+SPR+L K G
Sbjct: 135 SLFQLMVMTGILLAYITNYSFSGFYTGWRWMLGFAAIPAALLFLGGLILPESPRFLVKSG 194
Query: 213 HLKESDSALQRLRGKNADVHQEAA---EIRDYTETLQRQTEASIIGLFQWKYMTSLTIGV 269
HL E+ L + + H + A EI D E+ + LF SL IG+
Sbjct: 195 HLDEARHVLDTM-----NKHDQVAVNKEINDIQES-AKIVSGGWSELFGKMVRPSLIIGI 248
Query: 270 GLMILQQFGGINGIVFYANSIFVSAGFSESIGTIAMVAV---KIPVTVLGVLLMDKSGRR 326
GL I QQ G N +++YA +IF GF S +A + + + VT + V +MDK R+
Sbjct: 249 GLAIFQQVMGCNTVLYYAPTIFTDVGFGVSAALLAHIGIGIFNVIVTAIAVAIMDKIDRK 308
Query: 327 PLLLLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIM 386
++ + A G + F+ ++ G + + I++++ + VY+ +S G + WV++
Sbjct: 309 KIVNIGAVGMGISLFVMSIGMKFSGGSQ---TAAIISVIALTVYIAFFSATWGPVMWVMI 365
Query: 387 SEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSWSSTGTFFI-FSSICGFTVLFVAK 445
E+FP+N++G S + NW + IVS F L+ + TG+ FI + +C ++ FV K
Sbjct: 366 GEVFPLNIRGLGNSFASVINWTANMIVSLTFPSLLDFFGTGSLFIGYGILCFASIWFVQK 425
Query: 446 LVPETKGRTLEEIQASL 462
V ET+ R+LE+I+A+L
Sbjct: 426 KVFETRNRSLEDIEATL 442
>CSBC_BACSU (P46333) Probable metabolite transport protein csbC
Length = 461
Score = 218 bits (555), Expect = 3e-56
Identities = 144/444 (32%), Positives = 232/444 (51%), Gaps = 23/444 (5%)
Query: 38 LGSYAFGAAIGYSSPTQSAIMPDLNLTVAQFSIFGSILTIGAMIGAIVSGKVADYAGRRV 97
LG +G G S I D+ LT + S+L +GA+ G+ +SG +D GRR
Sbjct: 16 LGGLLYGYDTGVISGALLFINNDIPLTTLTEGLVVSMLLLGAIFGSALSGTCSDRWGRRK 75
Query: 98 AMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFT 157
+ + I+G L FS+ L R+++G +G + +VPVY++E+ P +RG
Sbjct: 76 VVFVLSIIFIIGALACAFSQTIGMLIASRVILGLAVGGSTALVPVYLSEMAPTKIRGTLG 135
Query: 158 TMHQLMICCGMSLTYLIG----AFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGH 213
TM+ LMI G+ L Y++ F WR + + A+P L+ + F+P+SPRWL K G
Sbjct: 136 TMNNLMIVTGILLAYIVNYLFTPFEAWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGS 195
Query: 214 LKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLFQWKYM-TSLTIGVGLM 272
+E + + D+ E AE++ + + + + +G+ + K++ L IGVGL
Sbjct: 196 -EEEARRIMNITHDPKDIEMELAEMKQG----EAEKKETTLGVLKAKWIRPMLLIGVGLA 250
Query: 273 ILQQFGGINGIVFYANSIFVSAGFSES---IGTIAMVAVKIPVTVLGVLLMDKSGRRPLL 329
I QQ GIN +++YA +IF AG S +GT+ + + + + + ++L+D+ GR+ LL
Sbjct: 251 IFQQAVGINTVIYYAPTIFTKAGLGTSASALGTMGIGILNVIMCITAMILIDRVGRKKLL 310
Query: 330 LLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVL---VYVGSYSLGMGAIPWVIM 386
+ + G L LAAL+ +L L G+S A + V+ VY+ Y G + WV+M
Sbjct: 311 IWGSVGITLS--LAALSGVLLTL----GLSASTAWMTVVFLGVYIVFYQATWGPVVWVLM 364
Query: 387 SEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMS-WSSTGTFFIFSSICGFTVLFVAK 445
E+FP +G+A T + IVS F ++S F +FS IC + F
Sbjct: 365 PELFPSKARGAATGFTTLVLSAANLIVSLVFPLMLSAMGIAWVFMVFSVICLLSFFFAFY 424
Query: 446 LVPETKGRTLEEIQASLSSHSTKR 469
+VPETKG++LEEI+ASL K+
Sbjct: 425 MVPETKGKSLEEIEASLKKRFKKK 448
>GTR4_HUMAN (P14672) Solute carrier family 2, facilitated glucose
transporter, member 4 (Glucose transporter type 4,
insulin-responsive)
Length = 509
Score = 218 bits (554), Expect = 3e-56
Identities = 156/486 (32%), Positives = 247/486 (50%), Gaps = 37/486 (7%)
Query: 16 DEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLT----------- 64
D E QQR T TL L+ AVLGS FG IG + Q I N T
Sbjct: 12 DGEPPQQR-VTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPS 70
Query: 65 -------VAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSK 117
+++ +I ++G MI + + G ++ + GR+ AM + + +LG ++ +
Sbjct: 71 SIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLAN 130
Query: 118 VAW---WLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCG------M 168
A L +GR L+G GL S +VP+YV EI P +LRG T++QL I G +
Sbjct: 131 AAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVL 190
Query: 169 SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLK-ESDSALQRLRGK 227
L L+G W +L + +P QL+ LPF P+SPR+L + +L+ + +L+RL G
Sbjct: 191 GLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGW 250
Query: 228 NADVHQEAAEIRDYTETLQRQTEASIIGLFQWK-YMTSLTIGVGLMILQQFGGINGIVFY 286
ADV AE++D L+R+ S++ L + + L I V L + QQ GIN + +Y
Sbjct: 251 -ADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYY 309
Query: 287 ANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAAL 345
+ SIF +AG + + TI V T++ VLL++++GRR L LL AG C GC +
Sbjct: 310 STSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMC-GCAILMT 368
Query: 346 AFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFF 405
LL L E +++V + +V + +G G IPW I++E+F + +A ++ F
Sbjct: 369 VALL--LLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFS 426
Query: 406 NWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQASLSSH 465
NW ++I+ F ++ F +F+ + +F VPET+GRT ++I A+ H
Sbjct: 427 NWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAF--H 484
Query: 466 STKRLI 471
T L+
Sbjct: 485 RTPSLL 490
>GTR3_MOUSE (P32037) Solute carrier family 2, facilitated glucose
transporter, member 3 (Glucose transporter type 3,
brain)
Length = 493
Score = 216 bits (550), Expect = 1e-55
Identities = 148/473 (31%), Positives = 246/473 (51%), Gaps = 36/473 (7%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLTV--------------AQFSIF 71
T +L + VA +GS+ FG G + ++ + LN T+ A +S+
Sbjct: 7 TPSLVFAVTVATIGSFQFGYNTGVINAPETILKDFLNYTLEERLEDLPSEGLLTALWSLC 66
Query: 72 GSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVAW---WLYVGRLL 128
+I ++G MIG+ G + GRR +M L I+ ++ F+K+A L +GRLL
Sbjct: 67 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLLAIIAGCLMGFAKIAESVEMLILGRLL 126
Query: 129 VGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCGM------SLTYLIGAFVNWRI 182
+G GL + VP+Y+ E++P LRG F T++QL I G+ L +++G+ W
Sbjct: 127 IGIFCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQIFGLDFILGSEELWPG 186
Query: 183 LALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLKESDSA---LQRLRGKNADVHQEAAEIR 239
L + IP Q +LPF P+SPR+L + + KE D A LQRL G +DV QE E++
Sbjct: 187 LLGLTIIPAILQSAALPFCPESPRFL--LINKKEEDQATEILQRLWG-TSDVVQEIQEMK 243
Query: 240 DYTETLQRQTEASIIGLFQW-KYMTSLTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE 298
D + + ++ + +++ LF+ Y+ L I + L + QQ GIN + +Y+ IF AG E
Sbjct: 244 DESVRMSQEKQVTVLELFRSPNYVQPLLISIVLQLSQQLSGINAVFYYSTGIFKDAGVQE 303
Query: 299 SI-GTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALAFLLQGLHEWKG 357
I TI V TV+ + L++++GRR L ++ G + ++ LL+ +E
Sbjct: 304 PIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSVFMTISLLLKDDYE--- 360
Query: 358 VSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAF 417
+ +V +L+YV + +G G IPW I++E+F + +A ++ NW +++V F
Sbjct: 361 AMSFVCIVAILIYVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGCCNWTSNFLVGMLF 420
Query: 418 NFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQASL--SSHSTK 468
++ F IF++ F ++F VPETKGRT E+I + +HS K
Sbjct: 421 PSAAAYLGAYVFIIFAAFLIFFLIFTFFKVPETKGRTFEDIARAFEGQAHSGK 473
>ITR2_YEAST (P30606) Myo-inositol transporter 2
Length = 612
Score = 215 bits (547), Expect = 2e-55
Identities = 145/485 (29%), Positives = 240/485 (48%), Gaps = 38/485 (7%)
Query: 7 EISIPLVFNDEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLN---L 63
+ S+ + FN Q PF TLT VA + + FG GY S +I DL+ L
Sbjct: 97 DTSVIITFN----QSISPFIITLTF---VASISGFMFGYDTGYISSALISINRDLDNKVL 149
Query: 64 TVAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLY 123
T + + + ++GA+I ++ +G AD GRR + FS L ++G ++ + W +
Sbjct: 150 TYGEKELITAATSLGALITSVGAGTAADVFGRRPCLMFSNLMFLIGAILQITAHKFWQMA 209
Query: 124 VGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVN---- 179
GRL++G G+G+ S + P++++EI PK +RG T ++ L + G + Y GA +N
Sbjct: 210 AGRLIMGFGVGIGSLISPLFISEIAPKMIRGRLTVINSLWLTGGQLIAYGCGAGLNHVKN 269
Query: 180 -WRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLKESDSALQRLRGKNAD--VHQEAA 236
WRIL + IP Q F+PD+PR+ G LK + L+R D + Q+
Sbjct: 270 GWRILVGLSLIPTVLQFSFFCFLPDTPRYYVMKGDLKRAKMVLKRSYVNTEDEIIDQKVE 329
Query: 237 EIRDYTETLQRQTEASIIGLFQWKYMT------SLTIGVGLMILQQFGGINGIVFYANSI 290
E+ +++ + + + T +L IG GL +QQF G N +++++ +I
Sbjct: 330 ELSSLNQSIPGKNPITKFWNMVKELHTVPSNFRALIIGCGLQAIQQFTGWNSLMYFSGTI 389
Query: 291 FVSAGFSESIG-TIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALAFLL 349
F + GF S +I + T++ +DK GRR +LL+ G + + A+AF
Sbjct: 390 FETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKIGRRYILLIGLPGMTVALVICAIAFHF 449
Query: 350 QGLHEWKGVSPILA-----------LVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSA 398
G+ ++ G ++A +V ++VY Y+LG+G +PW SE+FP NV+G
Sbjct: 450 LGI-KFNGADAVVASDGFSSWGIVIIVFIIVYAAFYALGIGTVPWQ-QSELFPQNVRGVG 507
Query: 399 GSLVTFFNWLCSWIVSYAF-NFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEE 457
S T NW S +++ F L + + TGTF F+ + + +F PE G LEE
Sbjct: 508 TSYATATNWAGSLVIASTFLTMLQNITPTGTFSFFAGVACLSTIFCYFCYPELSGLELEE 567
Query: 458 IQASL 462
+Q L
Sbjct: 568 VQTIL 572
>GTR2_HUMAN (P11168) Solute carrier family 2, facilitated glucose
transporter, member 2 (Glucose transporter type 2,
liver)
Length = 524
Score = 214 bits (546), Expect = 3e-55
Identities = 149/501 (29%), Positives = 242/501 (47%), Gaps = 64/501 (12%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAI---------------------------- 57
T TL + + AVLGS+ FG IG + Q I
Sbjct: 7 TGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDE 66
Query: 58 MPDLNL-------------TVAQ-------FSIFGSILTIGAMIGAIVSGKVADYAGRRV 97
+P ++ TVA +S+ S +G M + G + D GR
Sbjct: 67 LPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIK 126
Query: 98 AMGFSQLFCILGWLVITFSKVA---WWLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRG 154
AM + + ++G L++ FSK+ + GR + G GL+S +VP+Y+ EI P LRG
Sbjct: 127 AMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRG 186
Query: 155 GFTTMHQLMICCGM------SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWL 208
T HQL I G+ L +++G + W IL + + Q L L F P+SPR+L
Sbjct: 187 ALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYL 246
Query: 209 -AKVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLF-QWKYMTSLT 266
K+ ++ +L+RLRG + DV ++ E+R E + + SII LF Y +
Sbjct: 247 YIKLDEEVKAKQSLKRLRGYD-DVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPIL 305
Query: 267 IGVGLMILQQFGGINGIVFYANSIFVSAGFSESI-GTIAMVAVKIPVTVLGVLLMDKSGR 325
+ + L + QQF GINGI +Y+ SIF +AG S+ + TI + AV + T + V L++K+GR
Sbjct: 306 VALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGR 365
Query: 326 RPLLLLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVI 385
R L L+ +G + ++ +L W ++++ + ++V + +G G IPW +
Sbjct: 366 RSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSY---VSMIAIFLFVSFFEIGPGPIPWFM 422
Query: 386 MSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAK 445
++E F + +A ++ F NW C++IV+ F ++ + FF+F+ + LF
Sbjct: 423 VAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFF 482
Query: 446 LVPETKGRTLEEIQASLSSHS 466
VPETKG++ EEI A S
Sbjct: 483 KVPETKGKSFEEIAAEFQKKS 503
>YFIG_BACSU (P54723) Hypothetical metabolite transport protein yfiG
Length = 482
Score = 213 bits (542), Expect = 9e-55
Identities = 137/452 (30%), Positives = 223/452 (49%), Gaps = 23/452 (5%)
Query: 33 TLVAVLGSYAFGAAIGYSSPTQS--AIMPDLNLTVAQFSIFGSILTIGAMIGAIVSGKVA 90
TLV+ G FG G + A LNLT + S L +GA GA+ G+++
Sbjct: 25 TLVSTFGGLLFGYDTGVINGALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLS 84
Query: 91 DYAGRRVAMGFSQLFCILGWLVITFSKVAWWLYVGRLLVGCGIGLLSYVVPVYVAEITPK 150
D GRR + + L I L TFS A + R L+G +G S VP ++AEI+P
Sbjct: 85 DRHGRRKTILYLALLFIAATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPA 144
Query: 151 NLRGGFTTMHQLMICCGMSLTYLIGAFVN---------WRILALIGAIPCFAQLLSLPFI 201
RG T ++LMI G L Y A + WR + +I +P + +
Sbjct: 145 ERRGRIVTQNELMIVIGQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIV 204
Query: 202 PDSPRWLAKVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLFQWKY 261
P+SPRWLA G + ++ L+++R +++ QE EI+ E + +A +
Sbjct: 205 PESPRWLAAKGRMGDALRVLRQIR-EDSQAQQEIKEIKHAIEGTAK--KAGFHDFQEPWI 261
Query: 262 MTSLTIGVGLMILQQFGGINGIVFYANSIFVSAGFSES---IGTIAMVAVKIPVTVLGVL 318
L IG+G+ I+QQ G+N I++Y I AGF IG IA + + + G+
Sbjct: 262 RRILFIGIGIAIVQQITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIW 321
Query: 319 LMDKSGRRPLLLLSAAGTCLGCFL-AALAFLLQGLHEWKGVSPILALVGVLVYVGSYSLG 377
L+ K RRP+L++ GT L L+ +L+G P + L ++++
Sbjct: 322 LLGKVRRRPMLIIGQIGTMTALLLIGILSIVLEG----TPALPYVVLSLTILFLAFQQTA 377
Query: 378 MGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSW-SSTGTFFIFSSIC 436
+ + W+++SEIFP++V+G + TF W ++++ + F L++ + TFFIF ++
Sbjct: 378 ISTVTWLMLSEIFPMHVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMN 437
Query: 437 GFTVLFVAKLVPETKGRTLEEIQASLSSHSTK 468
+LFV K VPETKGR+LE+++ S + +
Sbjct: 438 ILAILFVKKYVPETKGRSLEQLEHSFRQYGRR 469
>GTR4_BOVIN (Q27994) Solute carrier family 2, facilitated glucose
transporter, member 4 (Glucose transporter type 4,
insulin-responsive)
Length = 509
Score = 212 bits (540), Expect = 1e-54
Identities = 150/486 (30%), Positives = 241/486 (48%), Gaps = 37/486 (7%)
Query: 16 DEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLT----------- 64
D E +QR T TL L AVLGS FG IG + Q I N T
Sbjct: 12 DGEPPRQR-VTGTLVLGVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPG 70
Query: 65 -------VAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSK 117
+++ +I ++G MI + + G ++ + GR+ AM F+ +LG ++ +K
Sbjct: 71 SIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLFNNALAVLGGTLMGLAK 130
Query: 118 VAW---WLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCG------M 168
A L +GR +G GL S +VP+YV EI P +LRG T++QL I G +
Sbjct: 131 AAASYEMLILGRFFIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVTGILIAQVL 190
Query: 169 SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLK-ESDSALQRLRGK 227
L ++G W +L I +P Q++ LP P+SPR+L + +L+ + +L+RL G
Sbjct: 191 GLESMLGTATLWPLLLGITVLPALLQMVLLPLCPESPRYLYIIRNLEGPARKSLKRLTGW 250
Query: 228 NADVHQEAAEIRDYTETLQRQTEASIIGLF-QWKYMTSLTIGVGLMILQQFGGINGIVFY 286
ADV + AE+++ L+R+ S++ L + L I + L + QQ GIN + +Y
Sbjct: 251 -ADVSEVLAELKEEKRKLERERSLSLLQLLGSHTHRQPLVIAIVLQLSQQLSGINAVFYY 309
Query: 287 ANSIFVSAGFSE-SIGTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAAL 345
+ SIF SAG + + TI V T++ V L++++G R L LL AG C L +
Sbjct: 310 STSIFESAGVEKPAYATIGAGVVNTVFTLVSVFLVERAGHRTLHLLGLAGMCACAILMTV 369
Query: 346 AFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFF 405
A LL E +++V + +V + +G G IP I++E+F + +A ++ F
Sbjct: 370 ALLLL---ERVPAMSYVSIVAIFGFVAFFEIGPGPIPCFIVAELFSQGPRPAAMAVAGFS 426
Query: 406 NWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEIQASLSSH 465
NW C++I+ F ++ F +F+ + +F VPET+GRT ++I A H
Sbjct: 427 NWTCNFIIGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAVF--H 484
Query: 466 STKRLI 471
T L+
Sbjct: 485 RTPSLL 490
>GTR2_RAT (P12336) Solute carrier family 2, facilitated glucose
transporter, member 2 (Glucose transporter type 2,
liver)
Length = 522
Score = 209 bits (531), Expect = 2e-53
Identities = 144/499 (28%), Positives = 234/499 (46%), Gaps = 62/499 (12%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMP-------------------DLN---- 62
T TL + AVLGS+ FG IG + Q I+ D+N
Sbjct: 7 TGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDT 66
Query: 63 -----------------------LTVAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAM 99
+ +S+ S +G M+ + G + D GR AM
Sbjct: 67 PLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAM 126
Query: 100 GFSQLFCILGWLVITFSKVA---WWLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGF 156
+ + G L++ SK + GR + G GL+S +VP+Y+ EI P LRG
Sbjct: 127 LAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGAL 186
Query: 157 TTMHQLMICCGM------SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWL-A 209
T+HQL + G+ L++++G W IL + A+P Q L L F P+SPR+L
Sbjct: 187 GTLHQLALVTGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYL 246
Query: 210 KVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLF-QWKYMTSLTIG 268
+ + +L+RLRG D+ ++ E+R E + + S+I LF Y + +
Sbjct: 247 NLEEEVRAKKSLKRLRGTE-DITKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVA 305
Query: 269 VGLMILQQFGGINGIVFYANSIFVSAGFSESI-GTIAMVAVKIPVTVLGVLLMDKSGRRP 327
+ L + QQF GINGI +Y+ SIF +AG S+ + TI + A+ + T + VLL++K+GRR
Sbjct: 306 LMLHLAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRT 365
Query: 328 LLLLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIMS 387
L L G +L +L W +++ + ++V + +G G IPW +++
Sbjct: 366 LFLAGMIGMFFCAVFMSLGLVLLDKFTWMSY---VSMTAIFLFVSFFEIGPGPIPWFMVA 422
Query: 388 EIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKLV 447
E F + +A +L F NW+C++I++ F ++ + FF+F+ + LF V
Sbjct: 423 EFFSQGPRPTALALAAFSNWVCNFIIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKV 482
Query: 448 PETKGRTLEEIQASLSSHS 466
PETKG++ +EI A S
Sbjct: 483 PETKGKSFDEIAAEFRKKS 501
>GTR2_MOUSE (P14246) Solute carrier family 2, facilitated glucose
transporter, member 2 (Glucose transporter type 2,
liver)
Length = 523
Score = 208 bits (530), Expect = 2e-53
Identities = 145/500 (29%), Positives = 235/500 (47%), Gaps = 63/500 (12%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMP------------------------DL 61
T TL + AVL S+ FG IG + Q I+ D
Sbjct: 7 TGTLAFTVFTAVLSSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRKAAINYDVNGTDT 66
Query: 62 NLTVAQ-----------------------FSIFGSILTIGAMIGAIVSGKVADYAGRRVA 98
LTV +S+ S +G M+ + G + D GR A
Sbjct: 67 PLTVTPAYTTPAPWDEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKA 126
Query: 99 MGFSQLFCILGWLVITFSKVA---WWLYVGRLLVGCGIGLLSYVVPVYVAEITPKNLRGG 155
M + + G L++ SK + GR + G GL+S +VP+Y+ EI P LRG
Sbjct: 127 MLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGA 186
Query: 156 FTTMHQLMICCGM------SLTYLIGAFVNWRILALIGAIPCFAQLLSLPFIPDSPRWL- 208
T+HQL + G+ L++++G +W IL + A+P Q L L F P+SPR+L
Sbjct: 187 LGTLHQLALVTGILISQIAGLSFILGNQDHWHILLGLSAVPALLQCLLLLFCPESPRYLY 246
Query: 209 AKVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASIIGLF-QWKYMTSLTI 267
K+ + +L+RLRG DV ++ E++ E + + S+I LF Y + +
Sbjct: 247 IKLEEEVRAKKSLKRLRGTE-DVTKDINEMKKEKEEASTEQKVSVIQLFTDANYRQPILV 305
Query: 268 GVGLMILQQFGGINGIVFYANSIFVSAGFSESI-GTIAMVAVKIPVTVLGVLLMDKSGRR 326
+ L + QQF GINGI +Y+ SIF +AG S+ + TI + A+ + T + VLL++K+GRR
Sbjct: 306 ALMLHMAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRR 365
Query: 327 PLLLLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVLVYVGSYSLGMGAIPWVIM 386
L L G ++ +L W +++ + ++V + +G G IPW ++
Sbjct: 366 TLFLTGMIGMFFCTIFMSVGLVLLDKFAWMSY---VSMTAIFLFVSFFEIGPGPIPWFMV 422
Query: 387 SEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSWSSTGTFFIFSSICGFTVLFVAKL 446
+E F + +A +L F NW+C+++++ F ++ + FF+F+ + LF
Sbjct: 423 AEFFSQGPRPTALALAAFSNWVCNFVIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFK 482
Query: 447 VPETKGRTLEEIQASLSSHS 466
VPETKG++ EEI A S
Sbjct: 483 VPETKGKSFEEIAAEFRKKS 502
>ITR1_YEAST (P30605) Myo-inositol transporter 1
Length = 584
Score = 208 bits (529), Expect = 3e-53
Identities = 144/487 (29%), Positives = 237/487 (48%), Gaps = 42/487 (8%)
Query: 7 EISIPLVFNDEEQQQQRPFTATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLN---L 63
+ S+ + FN Q PF TLT VA + + FG GY S +I DL+ L
Sbjct: 71 DTSVMITFN----QSLSPFIITLTF---VASISGFMFGYDTGYISSALISIGTDLDHKVL 123
Query: 64 TVAQFSIFGSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVAWWLY 123
T + I + ++GA+I +I +G AD GR+ + S L ++G ++ + W +
Sbjct: 124 TYGEKEIVTAATSLGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMA 183
Query: 124 VGRLLVGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVN---- 179
VGRL++G G+G+ S + P++++EI PK +RG T ++ L + G + Y GA +N
Sbjct: 184 VGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNN 243
Query: 180 -WRILALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLKESDSALQRLRGKNADVHQEAAEI 238
WRIL + IP Q L F+PD+PR+ G L + L+R D +E E
Sbjct: 244 GWRILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLKR---SYTDTSEEIIER 300
Query: 239 R-DYTETLQRQTEASIIGLFQW----------KYMTSLTIGVGLMILQQFGGINGIVFYA 287
+ + TL + + W + +L IG GL +QQF G N +++++
Sbjct: 301 KVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFS 360
Query: 288 NSIFVSAGFSESIG-TIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALA 346
+IF + GF S +I + T++ +DK GRR +LL+ G + + ++A
Sbjct: 361 GTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIA 420
Query: 347 FLLQGLHEWKGVSPILA----------LVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKG 396
F G+ V+ +++ +V ++V+ Y+LG+G +PW SE+FP NV+G
Sbjct: 421 FHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPWQ-QSELFPQNVRG 479
Query: 397 SAGSLVTFFNWLCSWIVSYAF-NFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTL 455
S T NW S +++ F L + + GTF F+ + + +F PE G L
Sbjct: 480 IGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLEL 539
Query: 456 EEIQASL 462
EE+Q L
Sbjct: 540 EEVQTIL 546
>GTR3_CANFA (P47842) Solute carrier family 2, facilitated glucose
transporter, member 3 (Glucose transporter type 3,
brain)
Length = 495
Score = 207 bits (527), Expect = 5e-53
Identities = 140/461 (30%), Positives = 235/461 (50%), Gaps = 34/461 (7%)
Query: 26 TATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLNLTVAQ--------------FSIF 71
T +L + +A +GS+ FG G + ++ I LN T+ + +S+
Sbjct: 7 TVSLIFALSIATIGSFQFGYNTGVINAPETIIKDFLNYTLEEKSENLPTEVLLTSLWSLS 66
Query: 72 GSILTIGAMIGAIVSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVAW---WLYVGRLL 128
+I ++G MIG+ G + GRR +M L + G ++ F K+A L +GRL+
Sbjct: 67 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLMVNLLAVAGGCLMGFCKIAQSVEMLILGRLI 126
Query: 129 VGCGIGLLSYVVPVYVAEITPKNLRGGFTTMHQLMICCGMSLTYLIGAFVN------WRI 182
+G GL + VP+Y+ EI+P LRG F T++QL I G+ + + G V W +
Sbjct: 127 IGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLKVIMGTEELWPL 186
Query: 183 LALIGAIPCFAQLLSLPFIPDSPRWLAKVGHLKESDSA---LQRLRGKNADVHQEAAEIR 239
L IP Q +LPF P+SPR+L + + KE ++A LQRL G DV Q+ E++
Sbjct: 187 LLGFTIIPAVLQSAALPFCPESPRFL--LINRKEEENAKEILQRLWGTQ-DVSQDIQEMK 243
Query: 240 DYTETLQRQTEASIIGLFQWK-YMTSLTIGVGLMILQQFGGINGIVFYANSIFVSAGFSE 298
D + + ++ + +++ LF+ + Y + I + L + QQ GIN + +Y+ IF AG E
Sbjct: 244 DESARMAQEKQVTVLELFRSRSYRQPIIISIMLQLSQQLSGINAVFYYSTGIFKDAGVEE 303
Query: 299 SI-GTIAMVAVKIPVTVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALAFLLQGLHEWKG 357
I TI V TV+ + L++++GRR L ++ G + L ++ LL+ + W
Sbjct: 304 PIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSILMTISLLLKDNYNWMS 363
Query: 358 VSPILALVGVLVYVGSYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAF 417
+ + +LV+V + +G G IPW I++E+F + +A ++ NW +++V F
Sbjct: 364 ---FVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLF 420
Query: 418 NFLMSWSSTGTFFIFSSICGFTVLFVAKLVPETKGRTLEEI 458
+ F IF+ ++F VPET+GRT EEI
Sbjct: 421 PSAAFYLGAYVFIIFTGFLIVFLVFTFFKVPETRGRTFEEI 461
>GTR2_CHICK (Q90592) Solute carrier family 2, facilitated glucose
transporter, member 2 (Glucose transporter type 2,
liver)
Length = 533
Score = 204 bits (520), Expect = 3e-52
Identities = 137/449 (30%), Positives = 229/449 (50%), Gaps = 22/449 (4%)
Query: 27 ATLTLSTLVAVLGSYAFGAAIGYSSPTQSAIMPDLN--LTVAQFSIFGSILTIGAMIGAI 84
AT+T V + G+ A+G++ G +P+ P ++ + +S+ S+ +G M+ +
Sbjct: 70 ATIT----VTIPGTEAWGSSEGTLAPSAGFEDPTVSPHILTMYWSLSVSMFAVGGMVSSF 125
Query: 85 VSGKVADYAGRRVAMGFSQLFCILGWLVITFSKVA---WWLYVGRLLVGCGIGLLSYVVP 141
G + D GR AM + I G L++ +K+ + GR + G GL S +VP
Sbjct: 126 TVGWIGDRLGRVKAMLVVNVLSIAGNLLMGLAKMGPSHILIIAGRAITGLYCGLSSGLVP 185
Query: 142 VYVAEITPKNLRGGFTTMHQLMICCG------MSLTYLIGAFVNWRILALIGAIPCFAQL 195
+YV+E++P LRG T+HQL I G + L +L+G W +L + + Q
Sbjct: 186 MYVSEVSPTALRGALGTLHQLAIVTGILISQVLGLDFLLGNDELWPLLLGLSGVAALLQF 245
Query: 196 LSLPFIPDSPRWL-AKVGHLKESDSALQRLRGKNADVHQEAAEIRDYTETLQRQTEASII 254
L P+SPR+L K+G ++E+ +L+RLRG N D +E AE+ + + SI
Sbjct: 246 FLLLLCPESPRYLYIKLGKVEEAKKSLKRLRG-NCDPMKEIAEMEKEKQEAASEKRVSIG 304
Query: 255 GLFQW-KYMTSLTIGVGLMILQQFGGINGIVFYANSIFVSAGFSESI-GTIAMVAVKIPV 312
LF KY ++ + + + I QQF GIN I +Y+ +IF AG + + TI + V
Sbjct: 305 QLFSSSKYRQAVIVALMVQISQQFSGINAIFYYSTNIFQRAGVGQPVYATIGVGVVNTVF 364
Query: 313 TVLGVLLMDKSGRRPLLLLSAAGTCLGCFLAALAFLLQGLHEWKGVSPILALVGVLVYVG 372
TV+ V L++K+GRR L L G + + +L W +++V + ++V
Sbjct: 365 TVISVFLVEKAGRRSLFLAGLMGMLISAVAMTVGLVLLSQFAWMSY---VSMVAIFLFVI 421
Query: 373 SYSLGMGAIPWVIMSEIFPINVKGSAGSLVTFFNWLCSWIVSYAFNFLMSWSSTGTFFIF 432
+ +G G IPW I++E+F + +A ++ F NW C++IV F ++ F +F
Sbjct: 422 FFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFCNWACNFIVGMCFQYIADLCGPYVFVVF 481
Query: 433 SSICGFTVLFVAKLVPETKGRTLEEIQAS 461
+ + LF VPETKG++ EEI A+
Sbjct: 482 AVLLLVFFLFAYLKVPETKGKSFEEIAAA 510
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.326 0.140 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,744,239
Number of Sequences: 164201
Number of extensions: 2134268
Number of successful extensions: 8687
Number of sequences better than 10.0: 276
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 7825
Number of HSP's gapped (non-prelim): 386
length of query: 471
length of database: 59,974,054
effective HSP length: 114
effective length of query: 357
effective length of database: 41,255,140
effective search space: 14728084980
effective search space used: 14728084980
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 68 (30.8 bits)
Lotus: description of TM0544.5