BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0520.5
         (262 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

LIN1_NYCCO (P08548) LINE-1 reverse transcriptase homolog               90  5e-18
POL2_MOUSE (P11369) Retrovirus-related Pol polyprotein [Contains...    87  3e-17
LIN1_HUMAN (P08547) LINE-1 reverse transcriptase homolog               79  1e-14
POLR_DROME (P16423) Retrovirus-related Pol polyprotein from type...    74  4e-13
YTX2_XENLA (P14381) Transposon TX1 hypothetical 149 kDa protein ...    68  2e-11
MC50_ARATH (P92555) Hypothetical mitochondrial protein AtMg01250...    62  2e-09
PO23_POPJA (Q05118) Retrovirus-related Pol polyprotein from type...    55  2e-07
PO21_NASVI (Q03278) Retrovirus-related Pol polyprotein from type...    49  9e-06
PO22_POPJA (Q03274) Retrovirus-related Pol polyprotein from type...    49  1e-05
PO21_SCICO (Q03279) Retrovirus-related Pol polyprotein from type...    44  5e-04
RT16_MYXXA (P23072) RNA-directed DNA polymerase from retron Mx16...    34  0.41
HEM1_OCEIH (Q8EPM7) Glutamyl-tRNA reductase (EC 1.2.1.-) (GluTR)       33  0.54
CH62_CHLCV (P59698) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL...    33  0.91
MTB5_NEIGO (Q59605) Modification methylase NgoBV (EC 2.1.1.37) (...    32  2.0
PO12_NASVI (Q03270) Retrovirus-related Pol polyprotein from type...    30  4.5
IRA2_YEAST (P19158) Inhibitory regulator protein IRA2                  30  4.5
Y2R2_DROME (P16425) Hypothetical 115 kDa protein in type I retro...    30  5.9
KPRS_RALSO (Q8Y2E1) Ribose-phosphate pyrophosphokinase (EC 2.7.6...    30  5.9
ARH1_HUMAN (Q92888) Rho guanine nucleotide exchange factor 1 (p1...    30  7.7

>LIN1_NYCCO (P08548) LINE-1 reverse transcriptase homolog
          Length = 1260

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 66/235 (28%), Positives = 116/235 (49%), Gaps = 8/235 (3%)

Query: 20  KGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMWGVKCPKLSILWNCSKLP 79
           K +  + + ID EKA+D +   F+  TL   G     + LI      P  +I+ N  KL 
Sbjct: 589 KNKDHMILSIDAEKAFDNIQHPFMIRTLKKIGIEGTFLKLIEAIYSKPTANIILNGVKLK 648

Query: 80  SFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDV 139
           SF  + G RQG PLSP LF + ME LAI I+    +   K + I  + + +S   FADD+
Sbjct: 649 SFPLRSGTRQGCPLSPLLFNIVMEVLAIAIRE---EKAIKGIHIGSEEIKLS--LFADDM 703

Query: 140 LLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAVDHRRQINLSHIAGISRAS 199
           +++ + +++    +   +KE+   SG K+N  KS + F    +++ +  +      +   
Sbjct: 704 IVYLENTRDSTTKLLEVIKEYSNVSGYKINTHKS-VAFIYTNNNQAEKTVKDSIPFTVVP 762

Query: 200 DLGKYLGIPLLKG--RVTKAHFASLIGKMSSRLTSWKNNLLNRAGRVCLAKSVLM 252
              KYLG+ L K    + K ++ +L  +++  +  WKN   +  GR+ + K  ++
Sbjct: 763 KKMKYLGVYLTKDVKDLYKENYETLRKEIAEDVNKWKNIPCSWLGRINIVKMSIL 817


>POL2_MOUSE (P11369) Retrovirus-related Pol polyprotein [Contains:
           Reverse transcriptase (EC 2.7.7.49); Endonuclease]
          Length = 1300

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 74/251 (29%), Positives = 122/251 (48%), Gaps = 9/251 (3%)

Query: 4   NIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMWG 63
           NI  +  V+H I+  K    ++ I +D EKA+D++   F+   L   G     +++I   
Sbjct: 601 NIRKSINVIHYINKLKDKNHMI-ISLDAEKAFDKIQHPFMIKVLERSGIQGPYLNMIKAI 659

Query: 64  VKCPKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRI 123
              P  +I  N  KL +   + G RQG PLSPYLF + +E LA  I+    Q   K ++I
Sbjct: 660 YSKPVANIKVNGEKLEAIPLKSGTRQGCPLSPYLFNIVLEVLARAIRQ---QKEIKGIQI 716

Query: 124 TKDGVGISHLFFADDVLLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAVDH 183
            K+ V IS L  ADD++++    K   + + N +  F E  G K+N +KS M F    + 
Sbjct: 717 GKEEVKISLL--ADDMIVYISDPKNSTRELLNLINSFGEVVGYKINSNKS-MAFLYTKNK 773

Query: 184 RRQINLSHIAGISRASDLGKYLGIPLLK--GRVTKAHFASLIGKMSSRLTSWKNNLLNRA 241
           + +  +      S  ++  KYLG+ L K    +   +F SL  ++   L  WK+   +  
Sbjct: 774 QAEKEIRETTPFSIVTNNIKYLGVTLTKEVKDLYDKNFKSLKKEIKEDLRRWKDLPCSWI 833

Query: 242 GRVCLAKSVLM 252
           GR+ + K  ++
Sbjct: 834 GRINIVKMAIL 844


>LIN1_HUMAN (P08547) LINE-1 reverse transcriptase homolog
          Length = 1259

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 67/253 (26%), Positives = 118/253 (46%), Gaps = 13/253 (5%)

Query: 2   RDNIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIM 61
           R +I + Q +  T  T       + I ID EKA+D++   F+   L   G     + +I 
Sbjct: 576 RKSINIIQHINRTKDTNH-----MIISIDAEKAFDKIQQPFMLKPLNKLGIDGTYLKIIR 630

Query: 62  WGVKCPKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPV 121
                P  +I+ N  KL +   + G RQG PLSP L  + +E LA  I+    +   K +
Sbjct: 631 AIYDKPTANIILNGQKLEAPPLKTGTRQGCPLSPLLPNIVLEVLARAIRQ---EKEIKGI 687

Query: 122 RITKDGVGISHLFFADDVLLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAV 181
           ++ K+ V +S   FADD++++ +      Q +   +  F + SG K+N+ KS+  F    
Sbjct: 688 QLGKEEVKLS--LFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKINVQKSQ-AFLYTN 744

Query: 182 DHRRQINLSHIAGISRASDLGKYLGIPLLKG--RVTKAHFASLIGKMSSRLTSWKNNLLN 239
           + + +  +      + AS   KYLGI L +    + K ++  L+ ++      WKN   +
Sbjct: 745 NRQTESQIMSELPFTIASKRIKYLGIQLTRDVKDLFKENYKPLLNEIKEDTNKWKNIPCS 804

Query: 240 RAGRVCLAKSVLM 252
             GR+ + K  ++
Sbjct: 805 WVGRINIVKMAIL 817


>POLR_DROME (P16423) Retrovirus-related Pol polyprotein from type II
           retrotransposable element R2DM [Contains: Protease (EC
           3.4.23.-); Reverse transcriptase (EC 2.7.7.49);
           Endonuclease]
          Length = 1057

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 69/239 (28%), Positives = 106/239 (43%), Gaps = 23/239 (9%)

Query: 3   DNIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMW 62
           DN  +   V+   H+ K  R      +D+ KA+D +S   +  TL  +G P   VD +  
Sbjct: 457 DNATIVDLVLR--HSHKHFRSCYIANLDVSKAFDSLSHASIYDTLRAYGAPKGFVDYVQN 514

Query: 63  GVKCPKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVR 122
             +    S+  +      F P RG++QGDPLSP LF L M+RL   + + +         
Sbjct: 515 TYEGGGTSLNGDGWSSEEFVPARGVKQGDPLSPILFNLVMDRLLRTLPSEIG-------- 566

Query: 123 ITKDGVGISH-LFFADDVLLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAV 181
             K G  I++   FADD++LF +       L++ TL +F    G+K+N DK   +  K  
Sbjct: 567 -AKVGNAITNAAAFADDLVLFAETRMGLQVLLDKTL-DFLSIVGLKLNADKCFTVGIKGQ 624

Query: 182 DHRR---------QINLSHIAGISRASDLGKYLGIPLLKGRVTKAHFASLIGKMSSRLT 231
             ++          +  S I  + R +D  KYLGI        + + A  IG    RLT
Sbjct: 625 PKQKCTVLEAQSFYVGSSEIPSLKR-TDEWKYLGINFTATGRVRCNPAEDIGPKLQRLT 682


>YTX2_XENLA (P14381) Transposon TX1 hypothetical 149 kDa protein
           (ORF 2)
          Length = 1308

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 64/252 (25%), Positives = 112/252 (44%), Gaps = 13/252 (5%)

Query: 3   DNIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMW 62
           DN+ L ++++H    ++ G  L  + +D EKA+DRV   +L  TL  + F P+ V  +  
Sbjct: 569 DNVFLIRDLLH--FARRTGLSLAFLSLDQEKAFDRVDHQYLIGTLQAYSFGPQFVGYLKT 626

Query: 63  GVKCPKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVR 122
                +  +  N S     A  RG+RQG PLS  L+ L +E     ++  +T      + 
Sbjct: 627 MYASAECLVKINWSLTAPLAFGRGVRQGCPLSGQLYSLAIEPFLCLLRKRLT-----GLV 681

Query: 123 ITKDGVGISHLFFADDVLLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAVD 182
           + +  + +    +ADDV+L  Q     L+      + +  AS  ++N  KS  L   ++ 
Sbjct: 682 LKEPDMRVVLSAYADDVILVAQ-DLVDLERAQECQEVYAAASSARINWSKSSGLLEGSL- 739

Query: 183 HRRQINLSHIAGISRASDLGKYLGIPL-LKGRVTKAHFASLIGKMSSRLTSWKN--NLLN 239
            +          IS  S + KYLG+ L  +      +F  L   + +RL  WK    +L+
Sbjct: 740 -KVDFLPPAFRDISWESKIIKYLGVYLSAEEYPVSQNFIELEECVLTRLGKWKGFAKVLS 798

Query: 240 RAGRVCLAKSVL 251
             GR  +   ++
Sbjct: 799 MRGRALVINQLV 810


>MC50_ARATH (P92555) Hypothetical mitochondrial protein AtMg01250
           (ORF102)
          Length = 122

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 29/56 (51%), Positives = 37/56 (65%)

Query: 83  PQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADD 138
           P RGLRQGDPLSPYLF+LC E L+   +    QG    +R++ +   I+HL FADD
Sbjct: 24  PSRGLRQGDPLSPYLFILCTEVLSGLCRRAQEQGRLPGIRVSNNSPRINHLLFADD 79


>PO23_POPJA (Q05118) Retrovirus-related Pol polyprotein from type I
           retrotransposable element R2 [Contains: Reverse
           transcriptase (EC 2.7.7.49); Endonuclease] (Fragment)
          Length = 606

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 50/188 (26%), Positives = 83/188 (43%), Gaps = 17/188 (9%)

Query: 1   TRDNIILAQEVMHTIHTQK-KGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDL 59
           T  NII+ +   H I  ++ KG+    + +D+ KA+D VS   +   +  FG    + D 
Sbjct: 2   TLANIIMLE---HYIKLRRLKGKTYNVVSLDIRKAFDTVSHPAILRAMRAFGIDDGMQDF 58

Query: 60  IMWGVKCPKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWK 119
           IM  +     +I+           + G++QGDPLSP LF + ++ L  ++ +     +  
Sbjct: 59  IMSTITDAYTNIVVGGRTTNKIYIRNGVKQGDPLSPVLFNIVLDELVTRLNDEQPGASMT 118

Query: 120 PVRITKDGVGISHLFFADDVLLFCQASKEQLQLVNNTLKEFC---EASGMKVNLDKSRML 176
           P         I+ L FADD+LL      +    V N+L   C      GM +N +K   +
Sbjct: 119 P------ACKIASLAFADDLLLLEDRDID----VPNSLATTCAYFRTRGMTLNPEKCASI 168

Query: 177 FSKAVDHR 184
            +  V  R
Sbjct: 169 SAATVSGR 176


>PO21_NASVI (Q03278) Retrovirus-related Pol polyprotein from type I
           retrotransposable element R2 [Contains: Reverse
           transcriptase (EC 2.7.7.49); Endonuclease] (Fragment)
          Length = 1025

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 52/197 (26%), Positives = 86/197 (43%), Gaps = 18/197 (9%)

Query: 20  KGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMWGVKCPKLSILWNCSKLP 79
           K +GL    +D++KA+D V    +   L     P  + + IMW  +  K  +    +K  
Sbjct: 446 KIKGLYIAILDVKKAFDSVEHRSILDALRRKKLPLEMRNYIMWVYRNSKTRLEVVKTKGR 505

Query: 80  SFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDV 139
              P RG+RQGDPLSP LF   M+     +   + + T   +   K G     L FADD+
Sbjct: 506 WIRPARGVRQGDPLSPLLFNCVMD----AVLRRLPENTGFLMGAEKIGA----LVFADDL 557

Query: 140 LLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLFSKAVDHRRQINLS----HIAGI 195
           +L  + ++E LQ   + ++   +  G+++   K   L        ++I +        G 
Sbjct: 558 VLLAE-TREGLQASLSRIEAGLQEQGLEMMPRKCHTLALVPSGKEKKIKVETHKPFTVGN 616

Query: 196 SRASDLG-----KYLGI 207
              + LG     KYLG+
Sbjct: 617 QEITQLGHADQWKYLGV 633


>PO22_POPJA (Q03274) Retrovirus-related Pol polyprotein from type I
           retrotransposable element R2 [Contains: Reverse
           transcriptase (EC 2.7.7.49); Endonuclease] (Fragment)
          Length = 711

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 48/171 (28%), Positives = 77/171 (44%), Gaps = 10/171 (5%)

Query: 4   NIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMWG 63
           N +L    + +   Q+K   +V++  D+ KA+D VS   +   L   G      + I   
Sbjct: 119 NSLLLDTYISSRREQRKTYNVVSL--DVRKAFDTVSHSSICRALQRLGIDEGTSNYITGS 176

Query: 64  VKCPKLSI-LWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVR 122
           +     +I +   S+      +RG++QGDPLSP+LF   ++ L   +Q+  T G    + 
Sbjct: 177 LSDSTTTIRVGPGSQTRKICIRRGVKQGDPLSPFLFNAVLDELLCSLQS--TPGIGGTIG 234

Query: 123 ITKDGVGISHLFFADDVLLFCQASKEQLQLVNNTLKEFCEASGMKVNLDKS 173
             K    I  L FADD+LL  + +   L     T+  F    GM +N  KS
Sbjct: 235 EEK----IPVLAFADDLLLL-EDNDVLLPTTLATVANFFRLRGMSLNAKKS 280


>PO21_SCICO (Q03279) Retrovirus-related Pol polyprotein from type I
           retrotransposable element R2 [Contains: Reverse
           transcriptase (EC 2.7.7.49); Endonuclease] (Fragment)
          Length = 869

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 52/193 (26%), Positives = 80/193 (40%), Gaps = 29/193 (15%)

Query: 29  IDLEKAYDRVSWDFLRATLYDFGFPPRIVDLI--MWGVKCPKLSILWNCSKLPSFAPQRG 86
           +DL KA++ V    L   + + G PP +VD I  M+     ++     C      A   G
Sbjct: 296 LDLVKAFNSVYHSALIDAITEAGCPPGVVDYIADMYNNVITEMQFEGKCELASILA---G 352

Query: 87  LRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDVLLFCQ-- 144
           + QGDPLS  LF L  E+    + N   +G     R     V ++   ++DD LL     
Sbjct: 353 VYQGDPLSGPLFTLAYEKALRALNN---EG-----RFDIADVRVNASAYSDDGLLLAMTV 404

Query: 145 -ASKEQLQLVNNTLKEFCEASGMKVNLDKSRMLF---------SKAVDHRRQINLSHIAG 194
              +  L     TL +     G+++N  KS+ +           K V +RR +  +    
Sbjct: 405 IGLQHNLDKFGETLAKI----GLRINSRKSKTVSLVPSGREKKMKIVSNRRLLLKASELK 460

Query: 195 ISRASDLGKYLGI 207
               SDL KYLG+
Sbjct: 461 PLTISDLWKYLGV 473


>RT16_MYXXA (P23072) RNA-directed DNA polymerase from retron
           Mx162-RT (EC 2.7.7.49) (Reverse transcriptase)
           (Mx162-RT)
          Length = 485

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 34/161 (21%), Positives = 67/161 (41%), Gaps = 22/161 (13%)

Query: 25  VAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLI-MWGVKCPKLSILWNCSKLPSFAP 83
           V +K+DL+  +  V+W  ++  L   G       L+ +   + P+ ++ +    L     
Sbjct: 245 VVVKVDLKDFFPSVTWRRVKGLLRKGGLREGTSTLLSLLSTEAPREAVQFRGKLLHVAKG 304

Query: 84  QRGLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDVLLFC 143
            R L QG P SP             I N +     K +      +G ++  +ADD+    
Sbjct: 305 PRALPQGAPTSP------------GITNALCLKLDKRLSALAKRLGFTYTRYADDLTFSW 352

Query: 144 QASKE---------QLQLVNNTLKEFCEASGMKVNLDKSRM 175
             +K+          + ++ + ++E  EA G +V+ DK+R+
Sbjct: 353 TKAKQPKPRRTQRPPVAVLLSRVQEVVEAEGFRVHPDKTRV 393


>HEM1_OCEIH (Q8EPM7) Glutamyl-tRNA reductase (EC 1.2.1.-) (GluTR)
          Length = 457

 Score = 33.5 bits (75), Expect = 0.54
 Identities = 17/56 (30%), Positives = 28/56 (49%)

Query: 3   DNIILAQEVMHTIHTQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVD 58
           D+I++ +E+M  +  Q+KGR L  + I + +  D    +     LYD      IVD
Sbjct: 253 DSIVVTKEMMEKVQKQRKGRALFLVDIAVPRDMDPAISELENVFLYDIDNLQHIVD 308


>CH62_CHLCV (P59698) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL
           protein 2)
          Length = 536

 Score = 32.7 bits (73), Expect = 0.91
 Identities = 21/73 (28%), Positives = 31/73 (41%), Gaps = 13/73 (17%)

Query: 60  IMWGVKC-------PKLSILWNCSKLPSFAPQRGLRQGDPLSPYLFVLCMERLAIQIQNL 112
           +M+G KC       P   +  NC K P +     L+  DP   Y    C+       +NL
Sbjct: 437 VMFGCKCMLQSAEEPLRVLATNCGKDPEYVVDTVLKHADP---YFGYNCIND---SFENL 490

Query: 113 VTQGTWKPVRITK 125
           +T G + P  +TK
Sbjct: 491 ITSGVFDPFSVTK 503


>MTB5_NEIGO (Q59605) Modification methylase NgoBV (EC 2.1.1.37)
           (Cytosine-specific methyltransferase NgoBV) (M.NgoBV)
           (M.NgoV)
          Length = 423

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 42/158 (26%), Positives = 66/158 (41%), Gaps = 17/158 (10%)

Query: 17  TQKKGRGLVAIKIDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMWGVKCPKLSILWNCS 76
           TQK GR L  I   LE     VSW  L A   +FG P     + + G    K  + +  S
Sbjct: 132 TQKIGRTLTVILETLEALGYYVSWKVLNAK--EFGIPQNRKRIYLTGSLKSKPDLSFETS 189

Query: 77  KLPSFAPQRGLRQGDPL--SPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLF 134
             P    +  L  G P   SP++  L  +    ++            +  KD  G  +  
Sbjct: 190 PSPKL--KNILESGLPTESSPFIKKLLKKFPPSELYG----------KSVKDKRGGKNNI 237

Query: 135 FADDVLLFCQASKEQLQLVNNTLKEFCEASGM-KVNLD 171
            + D+ L    ++E+ QL+N  LKE  + +G+ K+ +D
Sbjct: 238 HSWDIELKGAVTEEEKQLLNILLKERRKKNGLQKIGID 275


>PO12_NASVI (Q03270) Retrovirus-related Pol polyprotein from type I
           retrotransposable element R1 [Contains: Reverse
           transcriptase (EC 2.7.7.49); Endonuclease] (Fragment)
          Length = 410

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 36/162 (22%), Positives = 68/162 (41%), Gaps = 26/162 (16%)

Query: 86  GLRQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDVLLFCQA 145
           G  QG    P L+ L M  + I++                 G G+S   FADDV +  + 
Sbjct: 1   GCPQGSIGGPILWNLSMNGMLIELA----------------GSGVSVCAFADDVAILAEG 44

Query: 146 S--KEQLQLVNNTLK---EFCEASGMKVNLDKS--RMLFSKAVDHRRQINLSHIAGISRA 198
           +  KE  +++N  ++   ++ E  G+ V+ +K+   +L  K V   R + +S    + + 
Sbjct: 45  NTRKEVERVINEKMEIVYKWGEKMGVSVSEEKTVCMLLKGKYVTSNRAVRVSKTINVYKR 104

Query: 199 ---SDLGKYLGIPLLKGRVTKAHFASLIGKMSSRLTSWKNNL 237
                  +YLG+ + +G     H   +  K++  +   K  L
Sbjct: 105 IKYVSCFRYLGVNVTEGMGFGEHVRGMKVKVAKGVQKLKRVL 146


>IRA2_YEAST (P19158) Inhibitory regulator protein IRA2
          Length = 3079

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 22/63 (34%), Positives = 33/63 (51%), Gaps = 8/63 (12%)

Query: 166  MKVNLDKSRMLFSKAVDHRRQINLSHIAGISRASDLGKY------LGIPLLKGRVTKAHF 219
            +K+N +K ++L    V   +    SH+AGI+ AS   +Y      L  PL+ G V +A F
Sbjct: 1151 LKINNEKRQILLDITVKFMKV--RSHLAGIAEASHHMEYISDSEKLTFPLIMGTVGRALF 1208

Query: 220  ASL 222
             SL
Sbjct: 1209 VSL 1211


>Y2R2_DROME (P16425) Hypothetical 115 kDa protein in type I
           retrotransposable element R1DM (ORF 2)
          Length = 1021

 Score = 30.0 bits (66), Expect = 5.9
 Identities = 44/204 (21%), Positives = 78/204 (37%), Gaps = 26/204 (12%)

Query: 29  IDLEKAYDRVSWDFLRATLYDFGFPPRIVDLIMW-GVKCPKLSILWNCSKLPSFAPQRGL 87
           +D + A+D V W    + L D G      ++ +W      + +++ + S        RG 
Sbjct: 577 VDFKGAFDNVEWSAALSRLADLG----CREMGLWQSFFSGRRAVIRSSSGTVEVPVTRGC 632

Query: 88  RQGDPLSPYLFVLCMERLAIQIQNLVTQGTWKPVRITKDGVGISHLFFADDVLLFCQA-S 146
            QG    P+++ + M+ L  ++Q                        +ADD+LL  +  S
Sbjct: 633 PQGSISGPFIWDILMDVLLQRLQPYCQLSA-----------------YADDLLLLVEGNS 675

Query: 147 KEQLQLVNNTLKEFCEASGMKVN--LDKSRMLFSKAVDHRRQINLSHIAGISRASDLG-K 203
           +  L+     L    E  G +V   L  S+ +        R+      AG +       +
Sbjct: 676 RAVLEEKGAQLMSIVETWGAEVGDCLSTSKTVIMLLKGALRRAPTVRFAGRNLPYVRSCR 735

Query: 204 YLGIPLLKGRVTKAHFASLIGKMS 227
           YLGI + +G     H ASL  +M+
Sbjct: 736 YLGITVSEGMKFLTHIASLRQRMT 759


>KPRS_RALSO (Q8Y2E1) Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
           (RPPK) (Phosphoribosyl pyrophosphate synthetase)
           (P-Rib-PP synthetase) (PRPP synthetase)
          Length = 316

 Score = 30.0 bits (66), Expect = 5.9
 Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 5/65 (7%)

Query: 192 IAGISRASDLGKYLGIPL--LKGRVTKAHFA---SLIGKMSSRLTSWKNNLLNRAGRVCL 246
           + G+ RA  L K LG+ L  +  R  KA+ A   ++IG++  R     +++++  G +C 
Sbjct: 173 VGGVVRARALAKQLGVDLAIIDKRRPKANVAEVMNIIGEVEGRNCVIMDDMIDTGGTLCK 232

Query: 247 AKSVL 251
           A  VL
Sbjct: 233 AAQVL 237


>ARH1_HUMAN (Q92888) Rho guanine nucleotide exchange factor 1
           (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide
           exchange factor) (Sub1.5)
          Length = 912

 Score = 29.6 bits (65), Expect = 7.7
 Identities = 20/56 (35%), Positives = 30/56 (52%), Gaps = 5/56 (8%)

Query: 103 ERLAIQIQNLVTQG--TWKPVRITKDGVGISHLFFADDVLLFCQASKEQLQLVNNT 156
           + L I  + LV +G  TW   R+TKD     H+   DD+LL  Q   E+L L +++
Sbjct: 639 KNLDITKKKLVHEGPLTW---RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHS 691


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.327    0.141    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,318,257
Number of Sequences: 164201
Number of extensions: 1171893
Number of successful extensions: 3215
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 3191
Number of HSP's gapped (non-prelim): 20
length of query: 262
length of database: 59,974,054
effective HSP length: 108
effective length of query: 154
effective length of database: 42,240,346
effective search space: 6505013284
effective search space used: 6505013284
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)