BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0437b.7
(824 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MST2_DROHY (Q08696) Axoneme-associated protein mst101(2) 168 5e-41
USO1_YEAST (P25386) Intracellular protein transport protein USO1 152 3e-36
MYS2_DICDI (P08799) Myosin II heavy chain, non muscle 144 7e-34
MYH9_CHICK (P14105) Myosin heavy chain, nonmuscle (Cellular myos... 144 1e-33
MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular... 140 1e-32
MYSS_CYPCA (Q90339) Myosin heavy chain, fast skeletal muscle 139 2e-32
MYHA_RAT (Q9JLT0) Myosin heavy chain, nonmuscle type B (Cellular... 139 2e-32
MYH2_HUMAN (Q9UKX2) Myosin heavy chain, skeletal muscle, adult 2... 138 5e-32
MYH8_HUMAN (P13535) Myosin heavy chain, skeletal muscle, perinat... 138 7e-32
MYH9_HUMAN (P35579) Myosin heavy chain, nonmuscle type A (Cellul... 137 2e-31
MYHA_BOVIN (Q27991) Myosin heavy chain, nonmuscle type B (Cellul... 136 3e-31
MYH3_HUMAN (P11055) Myosin heavy chain, fast skeletal muscle, em... 135 4e-31
MYHA_HUMAN (P35580) Myosin heavy chain, nonmuscle type B (Cellul... 135 6e-31
MYH3_RAT (P12847) Myosin heavy chain, fast skeletal muscle, embr... 134 7e-31
MYSC_CHICK (P29616) Myosin heavy chain, cardiac muscle isoform (... 134 1e-30
MYHD_HUMAN (Q9UKX3) Myosin heavy chain, skeletal muscle, extraoc... 134 1e-30
MYH7_HUMAN (P12883) Myosin heavy chain, cardiac muscle beta isof... 134 1e-30
MYH7_PIG (P79293) Myosin heavy chain, cardiac muscle beta isofor... 133 2e-30
MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (S... 133 2e-30
MYH4_RABIT (Q28641) Myosin heavy chain, skeletal muscle, juvenile 132 3e-30
>MST2_DROHY (Q08696) Axoneme-associated protein mst101(2)
Length = 1391
Score = 168 bits (426), Expect = 5e-41
Identities = 205/809 (25%), Positives = 369/809 (45%), Gaps = 57/809 (7%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGI-ENLESENKKLKKDIQE--EQAQRKVAIEG 73
K E+ KK C+++ + + K E E +E KK +K +E E A++K E
Sbjct: 359 KEEDEKKACKELAKKKKEADEKKKCEEAANKEKKAAEKKKCEKAAKERKEAAEKKKCEE- 417
Query: 74 KLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVK 133
AA + + +A + ++L ++I ++ A+ K C + K EK R + K
Sbjct: 418 --------AAKKEKEAAERKKCEELAKNI-KKAAEKKKCKEAAKKEKEAAERKKCEELAK 468
Query: 134 ILEKRIENLESENKKLK-KDIQE----EQAQRKIEIEGKLEKSNAFAALENEVSALKSEN 188
++K E + E K K++ E E+ +KI+ +K A E E + K
Sbjct: 469 KIKKAAEKKKCEETAKKGKEVAERKKCEELAKKIKKAEIKKKCKKLAKKEKETAEKKKCE 528
Query: 189 KKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK----SENKKLKQDILD--EQA 242
K KK +E A++K + + A + E SA K +E KK ++ + E A
Sbjct: 529 KAAKKR--KEAAEKKKCEKAAKKRKEAAEKKKCEKSAKKRKEAAEKKKCEKAAKERKEAA 586
Query: 243 QGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEG 302
+ K C+ KK EK V R + K ++K +E KK K+ ++E + E G
Sbjct: 587 EKKKCEEAAKK-EKEVAERKKCEELAKKIKKA-----AEKKKCKEAAKKEKEAAEREKCG 640
Query: 303 KLEISNAFAALENEVSAL-KSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSA 361
+L AA + + L K E + +K E+ A+++ K + + A A E E +
Sbjct: 641 ELAKKIKKAAEKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCAEA-AKKEKEAAE 699
Query: 362 LKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL 421
K + K++ +E A+ K C++L KK +K E + + A K L+ NKK
Sbjct: 700 KKKCEEAAKKE--KEAAERKKCEELAKKIKKAAEKKKCKKLAKKKKAGEKNKLKKGNKKG 757
Query: 422 KKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEK 481
KK ++E++ R++ + E A + E A + + + +E+A+ K +
Sbjct: 758 KKALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKCEKTAKKRKEEAEKKKCEKTA 817
Query: 482 LEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKEL 541
+ A + E +A K + A ++KC +++ E K ++ +K+
Sbjct: 818 KKRKEAAEKKKCEKAAKKRKEEAEKKKCEKTAKKRKETAEKKKC------EKAAKKRKQA 871
Query: 542 VEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANC-CSKCDELKKK 600
EK+K ++++ E+KK A A+K E A+K E+A E KC+EL KK
Sbjct: 872 AEKKKCEKAAKKRKEAAEKKKCAEAAKKEKELAEKKKCEEAAKKEKEVAERKKCEELAKK 931
Query: 601 CEKVAVGRNALRQAVKILEKGIEN-LESENKKLKKENEVSALKSEISALQQKCGAGAREG 659
+K A + + A K + G +N L+ + K KK+ + KS+ +A ++KC A++
Sbjct: 932 IKKAAEKKKCKKLAKKEKKAGEKNKLKKKAGKGKKKCKKLGKKSKRAAEKKKCAEAAKKE 991
Query: 660 NGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKK 719
+A +E + +KE E+++ +++ E+K A+KL EA +K
Sbjct: 992 K------EAATKKKCEERAKKQKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEK 1045
Query: 720 IAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAES 779
E + +L++ +KQ ER KL E ++ K+ +R A+K+K EK E
Sbjct: 1046 KQCEERAK----KLKEAAEQKQCEERAKKLK-EAAEKKQCEER--AKKEKEAAEKKQCEE 1098
Query: 780 KIKKAQERSESELDKKTADMEKQQAEEQK 808
+ KK +E +E + ++ A EK+ AE+++
Sbjct: 1099 RAKKLKEAAEKKQCEERAKKEKEAAEKKR 1127
Score = 158 bits (400), Expect = 5e-38
Identities = 206/825 (24%), Positives = 355/825 (42%), Gaps = 79/825 (9%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESEN--KKLKKDIQEEQA---QRKVAI 71
KCEE KK E+ V R + K ++K E + + KK K+ + E+ +K+
Sbjct: 590 KCEEAAKK-EKEVAERKKCEELAKKIKKAAEKKKCKEAAKKEKEAAEREKCGELAKKIKK 648
Query: 72 EGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQA 131
+ + A E E + K K+ +E A+ K C + K EK + +A
Sbjct: 649 AAEKKKCKKLAKKEKETAEKKKCEKAAKKR--KEAAEKKKCAEAAKKEKEAAEKKKCEEA 706
Query: 132 VKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKL 191
K ++ E + E +L K I++ ++K + K +K+ E + LK NKK
Sbjct: 707 AKKEKEAAERKKCE--ELAKKIKKAAEKKKCKKLAKKKKAG-------EKNKLKKGNKKG 757
Query: 192 KKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLK 251
KK + E++ R++A + E A + E A + + + E+A+ K C++
Sbjct: 758 KKALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKCEKTAKKRKEEAEKKKCEKTA 817
Query: 252 KKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA 311
KK ++ E + + A K E E+E KK +K A+++ E K + A
Sbjct: 818 KKRKEAAEKKKCEKAAKKRKE------EAEKKKCEKT-----AKKRKETAEKKKCEKAAK 866
Query: 312 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 371
+ K E K+ +E A++K E A E E++ K + K+
Sbjct: 867 KRKQAAEKKKCEKAAKKR---KEAAEKKKCAEA--------AKKEKELAEKKKCEEAAKK 915
Query: 372 DILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 431
+ +E A+ K C++L KK +K E + + A K E E KLKK + + +
Sbjct: 916 E--KEVAERKKCEELAKKIKKAAEKKKCKKLAKK------EKKAGEKNKLKK--KAGKGK 965
Query: 432 RKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAAL 491
+K + GK S A + A K E K EE+A+ + EK + L
Sbjct: 966 KKCKKLGKK--SKRAAEKKKCAEAAKKEKEAATKKKCEERAKKQKEAAEKKQCEERAKKL 1023
Query: 492 ENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLK-KELVEKEKIVAD 550
+ + E A + K A ++ + LK + E K KE EK++
Sbjct: 1024 KEAAEQKQCEERAKKLKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCEER 1083
Query: 551 SERKTAVDERKKAAAEARKLLEAA-KKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRN 609
++++ E+K+ A+KL EAA KK E+A + A +C+E K+ ++ A +
Sbjct: 1084 AKKEKEAAEKKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKRCEEAAKREKEAAEKKK 1143
Query: 610 ALRQAVKILE-----KGIENLESENKKLKKENEVSALKSEISALQ-QKCGAGAREGNGDV 663
A K E K E + E + +K+ A K E A Q +KC A++
Sbjct: 1144 CAEAAKKEKEATEKQKCAEAAKKEKEAAEKKKCAEAAKREKEAAQKKKCADLAKKEQEPA 1203
Query: 664 EVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEA--PKKIA 721
E+ K +E + +KE E+++ ++++ E+K A A+K EA KK A
Sbjct: 1204 EMKKC------EEAAKKEKEAAEKQKCAKAAKKEKEAAEKKKCAEAAKKEQEAAEKKKCA 1257
Query: 722 AEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFE----AEKKKLLVEKINA 777
+K+ + R+ ++ K + A + + KEA R + A+K K+ EK
Sbjct: 1258 EAAKKEKEAEKKRKCEKAEKAAALKRQCAKLVIRAKEAALRKKCAIIAKKAKMAAEKKEC 1317
Query: 778 ESKIKKAQERSE----SELDKKTADMEKQQ----AEEQKKLAEDK 814
E KKA+E E ++L KK + EK++ A+++K+ AE K
Sbjct: 1318 EKLAKKAKEAIEWKKCAKLAKKKREAEKKKCAKLAKKEKEAAEKK 1362
Score = 155 bits (392), Expect = 4e-37
Identities = 210/851 (24%), Positives = 363/851 (41%), Gaps = 68/851 (7%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
KCEEL KK ++ + + + A K E + + K +K+ E++ K A + K
Sbjct: 494 KCEELAKKIKKAEIKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCEKAAKKRKEA 553
Query: 77 ISNTFAALENEVSALISENKKLKQDILE--EQAQGKICDQLKKCEKVVEGRNALRQAVKI 134
+ +E KK ++ E E A+ K C++ K EK V R + K
Sbjct: 554 AEKKKCEKSAKKRKEAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEVAERKKCEELAKK 613
Query: 135 LEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSAL-KSENKKLKK 193
++K +E KK K+ ++E+ + E G+L K AA + + L K E + +K
Sbjct: 614 IKKA-----AEKKKCKEAAKKEKEAAEREKCGELAKKIKKAAEKKKCKKLAKKEKETAEK 668
Query: 194 DILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKK 253
E+ A+++ K + + A A E E + K + K++ E A+ K C+ L KK
Sbjct: 669 KKCEKAAKKRKEAAEKKKCAEA-AKKEKEAAEKKKCEEAAKKE--KEAAERKKCEELAKK 725
Query: 254 CEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAAL 313
+K E + + A K L+ NKK KK ++E+ R++ + E A
Sbjct: 726 IKKAAEKKKCKKLAKKKKAGEKNKLKKGNKKGKKALKEKKKCRELAKKKAAEKKKCKEAA 785
Query: 314 ENEVSAL---------KSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKS 364
+ E A K ++ +K E+ A+++ K + A + E K
Sbjct: 786 KKEKEAAEKKKCEKTAKKRKEEAEKKKCEKTAKKRKEAAEKKKCEKAAKKRKEEAEKKKC 845
Query: 365 ENKKLKQDILEEQAQGKFCDQL---------KKKCEKVVEGRNALRQAVKILEKGIENLE 415
E K+ +E A+ K C++ KKKCEK + R + K E + E
Sbjct: 846 EKTAKKR---KETAEKKKCEKAAKKRKQAAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKE 902
Query: 416 SENKKL-------KKDIQE----EQAQRKIEIEGKLEISNAFAALEN---EVSALKSEST 461
KK +K++ E E+ +KI+ + + A E E + LK ++
Sbjct: 903 LAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKKLAKKEKKAGEKNKLKKKAG 962
Query: 462 KLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVE 521
K KK + + K A E+K + + A + + K E A +QK A ++ +
Sbjct: 963 KGKKKCKKLGKKSKRAAEKK-KCAEAAKKEKEAATKKKCEERAKKQKEAAEKKQCEERAK 1021
Query: 522 VLKAGISDTEKEVNTLK-KELVEKEKIVADSERKTAVDERKKAAAEARKLLEAA-KKIAP 579
LK + E K KE EK++ +++ E+K+ A+KL EAA KK
Sbjct: 1022 KLKEAAEQKQCEERAKKLKEAAEKKQCEERAKKLKEAAEQKQCEERAKKLKEAAEKKQCE 1081
Query: 580 EKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGI-----ENLESENKKLKK 634
E+A + A +C+E KK ++ A + +A K E E + E + +K
Sbjct: 1082 ERAKKEKEAAEKKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKRCEEAAKREKEAAEK 1141
Query: 635 ENEVSALKSEISALQ-QKCGAGAREGNGDVEVLK-AGISDTKKEVNRLKK--EHVEEERI 690
+ A K E A + QKC A++ E K A + +KE + KK + ++E+
Sbjct: 1142 KKCAEAAKKEKEATEKQKCAEAAKKEKEAAEKKKCAEAAKREKEAAQKKKCADLAKKEQE 1201
Query: 691 VADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLA 750
A+ ++ +++ AAE +K +A KK EK+ + + ++Q K K A
Sbjct: 1202 PAEMKKCEEAAKKEKEAAEKQKCAKAAKKEKEAAEKK----KCAEAAKKEQEAAEKKKCA 1257
Query: 751 FELSKTKEATKRFEAEK-KKLLVEKINAESKIKKAQE---RSESELDKKTADM--EKQQA 804
K KEA K+ + EK +K K + +A+E R + + K A M EK++
Sbjct: 1258 EAAKKEKEAEKKRKCEKAEKAAALKRQCAKLVIRAKEAALRKKCAIIAKKAKMAAEKKEC 1317
Query: 805 EEQKKLAEDKL 815
E+ K A++ +
Sbjct: 1318 EKLAKKAKEAI 1328
Score = 148 bits (373), Expect = 7e-35
Identities = 214/799 (26%), Positives = 357/799 (43%), Gaps = 97/799 (12%)
Query: 47 ENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISEN--KKLKQDI-- 102
+N E + K+L+++I +EQA+ + I G ++ EV E KK +D+
Sbjct: 291 KNDEKKEKELEREILKEQAEEEAKIRGVVK----------EVKKKCKEKALKKKCKDLGR 340
Query: 103 -LEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRK 161
++E+A+ K C L K +K + + A ++ K + E++ KK + E+A K
Sbjct: 341 KMKEEAEKKKCAALAKKQKEEDEKKACKELAK------KKKEADEKK-----KCEEAANK 389
Query: 162 IEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 221
+ + +K A E + K + KK+ +E A+RK E I A
Sbjct: 390 EKKAAEKKKCEKAAKERKEAAEKKKCEEAAKKE--KEAAERKKCEELAKNIKKA------ 441
Query: 222 EVSALKSENKKLKQDILDEQ--AQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLE 279
+E KK K+ E+ A+ K C+ L KK +K E + A +KG E E
Sbjct: 442 ------AEKKKCKEAAKKEKEAAERKKCEELAKKIKKAAEKKKCEETA----KKGKEVAE 491
Query: 280 SEN-KKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQR 338
+ ++L K I +K EI+ K + A E E + K K KK +E A++
Sbjct: 492 RKKCEELAKKI------KKAEIKKKCK---KLAKKEKETAEKKKCEKAAKKR--KEAAEK 540
Query: 339 KVAMEGKLEISNAFAALENEVSALK----SENKKLKQDILE--EQAQGKFCDQLKKKCEK 392
K + + A + E SA K +E KK ++ E E A+ K C++ KK EK
Sbjct: 541 KKCEKAAKKRKEAAEKKKCEKSAKKRKEAAEKKKCEKAAKERKEAAEKKKCEEAAKK-EK 599
Query: 393 VVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENE 452
V R + K ++K +E KK K+ ++E+ + E G+L AA + +
Sbjct: 600 EVAERKKCEELAKKIKKA-----AEKKKCKEAAKKEKEAAEREKCGELAKKIKKAAEKKK 654
Query: 453 VSAL-KSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGA 511
L K E +K E+ A+ + EK + + A + K E AA ++K A
Sbjct: 655 CKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCAEAAKKEKEAAEKKKCEEAAKKEKEAA 714
Query: 512 GSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSER-KTAVDERKKA------- 563
++ + +K + + KK+ EK K+ +++ K A+ E+KK
Sbjct: 715 ERKKCEELAKKIKKAAEKKKCKKLAKKKKAGEKNKLKKGNKKGKKALKEKKKCRELAKKK 774
Query: 564 AAEARKLLEAAKKI--APEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKG 621
AAE +K EAAKK A EK + A K + KKKCEK A R + K EK
Sbjct: 775 AAEKKKCKEAAKKEKEAAEKKKCEKTAKK-RKEEAEKKKCEKTAKKRKEAAEKKKC-EKA 832
Query: 622 IENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLK 681
+ + E +K K+ E +A K + +A ++KC A++ E K + K++ K
Sbjct: 833 AKKRKEEAEK--KKCEKTAKKRKETAEKKKCEKAAKKRKQAAEKKKCEKAAKKRKEAAEK 890
Query: 682 K---EHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHL 738
K E ++E+ +A+ ++ +++ AE +K E KKI EK+ K ++
Sbjct: 891 KKCAEAAKKEKELAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKKLAKK--- 947
Query: 739 EKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQ----ERSESELDK 794
EK+ E K KL + K K+ K+ + K+ +K AE+ K+ + ++ E K
Sbjct: 948 EKKAGE-KNKLKKKAGKGKKKCKKLGKKSKRAAEKKKCAEAAKKEKEAATKKKCEERAKK 1006
Query: 795 KTADMEKQQAEEQ-KKLAE 812
+ EK+Q EE+ KKL E
Sbjct: 1007 QKEAAEKKQCEERAKKLKE 1025
Score = 135 bits (341), Expect = 3e-31
Identities = 197/735 (26%), Positives = 315/735 (42%), Gaps = 102/735 (13%)
Query: 113 DQLKKCEKVVEGR--NALRQAVK-----ILEKRIENLESENKKLKKDIQ-----EEQAQR 160
++ KK +K+V+ R L +K + E R E E K+L + + R
Sbjct: 205 NRAKKGKKLVKNRFTQKLEHCIKSEWADVCECRQNFTEDERKRLAASYKCMGTKIKSICR 264
Query: 161 KIEIEGKLEKSNAFAALENEVSALKSEN-----KKLKKDILEEQAQRKVAMEGKLEISNA 215
K I E + + E + K +N K+L+++IL+EQA+ + + G
Sbjct: 265 KRVIAEMCEAAGYVKSSEPKKKGKKKKNDEKKEKELEREILKEQAEEEAKIRG------- 317
Query: 216 FAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGI 275
+K KK K E+A K C L +K ++ E + A K E+
Sbjct: 318 ---------VVKEVKKKCK-----EKALKKKCKDLGRKMKEEAEKKKCAALAKKQKEEDE 363
Query: 276 ENLESENKKLKKDIQE----EHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDI 331
+ E K KK+ E E A K + + + A E + K + KK+
Sbjct: 364 KKACKELAKKKKEADEKKKCEEAANKEKKAAEKKKCEKAAKERKEAAEKKKCEEAAKKE- 422
Query: 332 LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQ--AQGKFCDQLKKK 389
+E A+RK E I A +E KK K+ +E+ A+ K C++L KK
Sbjct: 423 -KEAAERKKCEELAKNIKKA------------AEKKKCKEAAKKEKEAAERKKCEELAKK 469
Query: 390 CEKVVEGRNALRQAVKILEKGIENLESEN-KKLKKDIQEEQAQRKIEIEGKLEISNAFAA 448
+K E + A +KG E E + ++L K I++ + ++K + K E A
Sbjct: 470 IKKAAEKKKCEETA----KKGKEVAERKKCEELAKKIKKAEIKKKCKKLAKKEKETA-EK 524
Query: 449 LENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQK 508
+ E +A K + KK + + K A E+K + E SA K + AA ++K
Sbjct: 525 KKCEKAAKKRKEAAEKKKCEKAAKKRKEAAEKK----------KCEKSAKKRKEAAEKKK 574
Query: 509 CGAGSREGNGDVEVLKAG-ISDTEKEVNTLKK---------ELVEKEKIVADSERKTAVD 558
C ++E E K + EKEV KK + EK+K ++++
Sbjct: 575 CEKAAKERKEAAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKCKEAAKKEKEAA 634
Query: 559 ERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKIL 618
ER+K A+K+ +AA+K +K E K KKKCEK A R + K
Sbjct: 635 EREKCGELAKKIKKAAEKKKCKKLAKKE------KETAEKKKCEKAAKKRKEAAEKKKCA 688
Query: 619 EKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKK--- 675
E + E+ KK+ E +A K + +A ++KC A++ E K KK
Sbjct: 689 EAAKKEKEAAE---KKKCEEAAKKEKEAAERKKCEELAKKIKKAAEKKKCKKLAKKKKAG 745
Query: 676 EVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPK--KIAAEVEKQIAKVEL 733
E N+LKK + + ++ A E+K + K AAE +K EA K K AAE +K +
Sbjct: 746 EKNKLKKGNKKGKK--ALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKCEKTAKK 803
Query: 734 RQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELD 793
R+ EK+ E+ K E ++ K+ K A+K+K EK E KK +E +E +
Sbjct: 804 RKEEAEKKKCEKTAKKRKEAAEKKKCEK--AAKKRKEEAEKKKCEKTAKKRKETAEKKKC 861
Query: 794 KKTADMEKQQAEEQK 808
+K A KQ AE++K
Sbjct: 862 EKAAKKRKQAAEKKK 876
Score = 124 bits (312), Expect = 8e-28
Identities = 195/797 (24%), Positives = 349/797 (43%), Gaps = 88/797 (11%)
Query: 53 NKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQG--K 110
+KK +K +EEQA+ + L++ A E S +++ L Q +++ G K
Sbjct: 68 DKKKQKQKEEEQAKIREYKRECLKVQKRVLAEEIRCSG--EKDRILIQGMMKCLTDGMKK 125
Query: 111 ICDQLKKCEKVVEGRNALRQA-------VKILEKRIENLESENKKLKKDIQEEQAQRKIE 163
C ++ K + + + A++ A VK L K+ E +S+ K+ ++ E + +
Sbjct: 126 ACTKIAKAKLIADKELAVQCAALSKKDKVKALLKKCEREKSKEKECNQNSPAEGDKDRT- 184
Query: 164 IEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEV 223
K K+ + N+ + K K K +++ + +K+ K E ++ +N
Sbjct: 185 ---KKGKTKGKSGGGNKKRSTKENRAKKGKKLVKNRFTQKLEHCIKSEWADVCECRQNFT 241
Query: 224 SALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENK 283
+ E K+L + K R + E K K +N E + K
Sbjct: 242 ---EDERKRLAASYKCMGTKIKSICRKRVIAEMCEAAGYVKSSEPKKKGKKKKNDEKKEK 298
Query: 284 KLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAME 343
+L+++I +E A+ + +I G ++ + + ALK + K L + + EE ++K A
Sbjct: 299 ELEREILKEQAEEEAKIRGVVKEVKK----KCKEKALKKKCKDLGRKMKEEAEKKKCAAL 354
Query: 344 GKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQA 403
K + E+E A K KK K E + K C++ K +K E + +A
Sbjct: 355 AKKQKE------EDEKKACKELAKKKK-----EADEKKKCEEAANKEKKAAEKKKC-EKA 402
Query: 404 VKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL 463
K ++ E + E K ++E A+RK E I A + + +A K +
Sbjct: 403 AKERKEAAEKKKCEEAAKK---EKEAAERKKCEELAKNIKKAAEKKKCKEAAKKEKEAAE 459
Query: 464 KKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVL 523
+K E +IK A E+K + E +A K + A ++KC +++ +
Sbjct: 460 RKKCEELAKKIKKAAEKK----------KCEETAKKGKEVAERKKCEELAKK------IK 503
Query: 524 KAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAV 583
KA I K++ +KE EK+K ++++ E+KK A+K EAA+K EK+
Sbjct: 504 KAEIKKKCKKLAKKEKETAEKKKCEKAAKKRKEAAEKKKCEKAAKKRKEAAEKKKCEKSA 563
Query: 584 -----IPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL--KKEN 636
E C E K+ EK A ++ K E L + KK KK+
Sbjct: 564 KKRKEAAEKKKCEKAAKERKEAAEKKKCEEAAKKEKEVAERKKCEELAKKIKKAAEKKKC 623
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIV-ADSE 695
+ +A K + +A ++KCG A++ + KA K++ + +KE E+++ A +
Sbjct: 624 KEAAKKEKEAAEREKCGELAKK------IKKAAEKKKCKKLAKKEKETAEKKKCEKAAKK 677
Query: 696 RKTAVDERKNA--------AAEARKLLEAPKKI--AAEVEK--QIAKVELRQVHLEKQVN 743
RK A +++K A AAE +K EA KK AAE +K ++AK + +K
Sbjct: 678 RKEAAEKKKCAEAAKKEKEAAEKKKCEEAAKKEKEAAERKKCEELAKKIKKAAEKKKCKK 737
Query: 744 ERKMKLAFELSKTKEATKRFEA---EKKK---LLVEKINAESKIKKAQERSESELDKKTA 797
K K A E +K K+ K+ + EKKK L +K + K K+A ++ + +KK
Sbjct: 738 LAKKKKAGEKNKLKKGNKKGKKALKEKKKCRELAKKKAAEKKKCKEAAKKEKEAAEKKKC 797
Query: 798 DMEKQQAEEQKKLAEDK 814
+ + A+++K+ AE K
Sbjct: 798 E---KTAKKRKEEAEKK 811
Score = 91.7 bits (226), Expect = 7e-18
Identities = 141/565 (24%), Positives = 242/565 (41%), Gaps = 53/565 (9%)
Query: 22 KKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTF 81
KKKCE+ R + K + + E+ KK K + + ++++A + K E +
Sbjct: 858 KKKCEKAAKKRKQAAEKKKCEKAAKKRKEAAEKK--KCAEAAKKEKELAEKKKCEEA--- 912
Query: 82 AALENEVSALISENKKLKQ--DILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRI 139
A E EV+ E KK ++ +++ A+ K C +L K EK +N L++ +K+
Sbjct: 913 AKKEKEVA----ERKKCEELAKKIKKAAEKKKCKKLAKKEKKAGEKNKLKKKAGKGKKKC 968
Query: 140 ENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQ 199
+ L ++K+ + + +A +K + +K A + E + K ++ KK L+E
Sbjct: 969 KKLGKKSKRAAEKKKCAEAAKKEKEAATKKKCEERAKKQKEAAEKKQCEERAKK--LKEA 1026
Query: 200 AQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVE 259
A++K E ++ A + E A KKLK E A+ K C+ KK ++ E
Sbjct: 1027 AEQKQCEERAKKLKEAAEKKQCEERA-----KKLK-----EAAEQKQCEERAKKLKEAAE 1076
Query: 260 GRNALRQAVKILEKGIEN-LESENKKLKKDIQ----EEHAQRKVEIEGKLEISNAFAALE 314
+ +A K E + E KKLK+ + EE A+++ E K A A E
Sbjct: 1077 KKQCEERAKKEKEAAEKKQCEERAKKLKEAAEKKQCEERAKKEKEAAEKKRCEEA-AKRE 1135
Query: 315 NEVSALK--SENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQD 372
E + K +E K +K+ E+Q + A + K E + E ++ KK D
Sbjct: 1136 KEAAEKKKCAEAAKKEKEATEKQKCAEAAKKEK-EAAEKKKCAEAAKREKEAAQKKKCAD 1194
Query: 373 IL---EEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILE-----KGIENLESENKKLKKD 424
+ +E A+ K C++ KK ++ E + + A K E K E + E + +K
Sbjct: 1195 LAKKEQEPAEMKKCEEAAKKEKEAAEKQKCAKAAKKEKEAAEKKKCAEAAKKEQEAAEKK 1254
Query: 425 IQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEI 484
E A+++ E E K + A + +ALK + KL E + K AI K +
Sbjct: 1255 KCAEAAKKEKEAEKKRKCEKA-----EKAAALKRQCAKLVIRAKEAALRKKCAIIAK-KA 1308
Query: 485 SNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEK 544
A E E A K++ A +KC +++ + A ++ EKE EK
Sbjct: 1309 KMAAEKKECEKLAKKAKEAIEWKKCAKLAKKKREAEKKKCAKLAKKEKEA-------AEK 1361
Query: 545 EKIVADSERKTAVDERKKAAAEARK 569
+K D + +KK E RK
Sbjct: 1362 KKRCKDLAKNKKKGHKKKGRNENRK 1386
>USO1_YEAST (P25386) Intracellular protein transport protein USO1
Length = 1790
Score = 152 bits (385), Expect = 3e-36
Identities = 197/864 (22%), Positives = 406/864 (46%), Gaps = 109/864 (12%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRK------VAIE 72
+ LK+ + A+ + ++ ++ NL E + + K++ E +++ + +
Sbjct: 902 KSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLT 961
Query: 73 GKLE-ISNTFAALENEVSALIS--ENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALR 129
KL+ ++N + ++ E +LI E K + I Q KI ++ E R ++
Sbjct: 962 EKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIE 1021
Query: 130 QAVKILEKRIENLESENKKL--KKDIQEEQAQRKIEI-EGKLEKSNAFAALENEVSALKS 186
+ ++ L+K I +LE +++ K D +++ + +I + + KLE A A + V+ + S
Sbjct: 1022 KNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLE--TATTANDENVNKI-S 1078
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKF 246
E K ++++ E A K ++ +LE LE ALK E K+ ++ + +E+ Q
Sbjct: 1079 ELTKTREELEAELAAYK-NLKNELETK-----LETSEKALK-EVKENEEHLKEEKIQ--- 1128
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEI 306
L+K+ + + N+LR ++ LEK E+L ++ KK ++ I + Q EI
Sbjct: 1129 ---LEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEI------ 1179
Query: 307 SNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNA----FAALENEVSAL 362
+ L +E+++ + EN+ +KK E + + K E SN AL ++ L
Sbjct: 1180 ----SQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKEL 1235
Query: 363 KSENKKLKQDILEE----QAQGKFCDQLKKKC----EKVVEGRNALRQAVKILEKGIENL 414
K +N+ + +LE +++ +L+ +C ++V E + L+ + K +E L
Sbjct: 1236 KKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLE-L 1294
Query: 415 ESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQI 474
+ E++K+K+++ + + KI++E +S A E+E+S LK S++ +K+ E+ ++
Sbjct: 1295 QKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKL 1354
Query: 475 KVAIEEKLEISNAFAALENE------------VSALKSEIAALQQKCGAGSRE-GNGDVE 521
K I+ K + L NE ++ L+ E+ LQ + ++E N E
Sbjct: 1355 KNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSE 1414
Query: 522 VLKAGISD---TEKEVNTLK----KELVEKEKIVADSERKTAVD-----------ERKKA 563
+ K +S+ E++ NT+K + L K+KI + E+ +++ E+ +A
Sbjct: 1415 LEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRA 1474
Query: 564 AAEAR-KLLEAAKKI----APEKAVIPEPANCCSKCD--------ELKKKCEKVAVGRNA 610
A E++ K+ E KK+ + EKA + + K + ELK E +
Sbjct: 1475 AQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEK 1534
Query: 611 LRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGI 670
L Q+ K E+ I+NL+ E L + ++ + +I L+ K A+ G+ ++E +K +
Sbjct: 1535 LEQSKKSAEEDIKNLQHEKSDL--ISRINESEKDIEELKSKLRIEAKSGS-ELETVKQEL 1591
Query: 671 SDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAK 730
++ ++++ +E+ + + D ER E K+ AE + E + + + +++ +
Sbjct: 1592 NNAQEKIRINAEENTVLKSKLEDIER-----ELKDKQAEIKSNQEEKELLTSRLKELEQE 1646
Query: 731 VELRQVHLEKQVNERKMKL-AFELSKTKEATKRFEAEKK-KLLVEKINA----ESKIKKA 784
++ Q +K ER+ ++ F++ K++ K E K LV K A E +KK
Sbjct: 1647 LDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKT 1706
Query: 785 QERSESELDKKTADMEKQQAEEQK 808
+ E++K +++ +AE K
Sbjct: 1707 TDSQRQEIEKLAKELDNLKAENSK 1730
Score = 138 bits (347), Expect = 7e-32
Identities = 155/654 (23%), Positives = 313/654 (47%), Gaps = 81/654 (12%)
Query: 20 ELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISN 79
+L+K+ + N+LR ++ LEK E+L ++ KK ++ I ++ Q I ++++
Sbjct: 1128 QLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEIS---QLND 1184
Query: 80 TFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCE--------KVVEGRNALRQA 131
+ + E ++ +N +L+ ++ ++ + LKK E K ++ +N +A
Sbjct: 1185 EITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEA 1244
Query: 132 VKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKL 191
+LE I+++ESE K+K ++Q+E ++ E+ +K A ++ L+ E++K+
Sbjct: 1245 -SLLES-IKSVESETVKIK-ELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKI 1301
Query: 192 KKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK---SENKKLKQDILDE---QAQGK 245
K+++ + + K+ +E +S A E+E+S LK SE +K ++ L++ + Q K
Sbjct: 1302 KEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIK 1361
Query: 246 FCDRLKKKCEKVVEGRNALRQA----VKILEKGIENLESENKKLKKDIQEEHAQ-RKVEI 300
+K+ + + EG + + Q + LE + L++EN+ K+I ++ KV +
Sbjct: 1362 N-QAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSL 1420
Query: 301 EGKL---EISNAFAALENEVSALKSE----NKKL-------KKDILEEQAQRKVAMEGKL 346
E N +L++E+ + K + ++KL K+D+ + Q + A E K
Sbjct: 1421 SNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKA 1480
Query: 347 EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCD-QLKKKCEKVVEGRNALRQAVK 405
++ LE E S K+E +K K+ + + ++ + + +LK E + + L Q+ K
Sbjct: 1481 KVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKK 1540
Query: 406 ILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKK 465
E+ I+NL+ E L I E + + E++ KL I + SE +K+
Sbjct: 1541 SAEEDIKNLQHEKSDLISRINESEKDIE-ELKSKLRIE----------AKSGSELETVKQ 1589
Query: 466 DILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKA 525
++ Q +I++ EE + + +E E+ ++EI + Q+
Sbjct: 1590 ELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQE------------------ 1631
Query: 526 GISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIP 585
EKE+ T + + +E+E DS ++ A ++ AE RK + K EKA++
Sbjct: 1632 -----EKELLTSRLKELEQE---LDSTQQKAQKSEEERRAEVRKF-QVEKSQLDEKAMLL 1682
Query: 586 EPA--NCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENE 637
E + +K K+ + V ++ RQ ++ L K ++NL++EN KLK+ NE
Sbjct: 1683 ETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANE 1736
Score = 133 bits (334), Expect = 2e-30
Identities = 196/888 (22%), Positives = 397/888 (44%), Gaps = 129/888 (14%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLES---ENKKLKKDIQEEQAQRKVAIEGKL 75
+EL +K + + ++L++ ILE ++N+ E +L+ ++ + + + A+ L
Sbjct: 772 KELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTAL---L 828
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCE----KVVEGRNALRQA 131
E +T E+ + L E+ I Q KK E K+ + AL +
Sbjct: 829 EYKSTIHKQEDSIKTL-------------EKGLETILSQKKKAEDGINKMGKDLFALSRE 875
Query: 132 VKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNA----FAALENEVSALKSE 187
++ +E+ +NL+ E K + Q+E K +I K+ + A ++ + + L E
Sbjct: 876 MQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKE 935
Query: 188 NKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKF- 246
+ + K+++E +++ + +++ +L N +++EN+ L + + + + +
Sbjct: 936 KEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQ 995
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLE---SENKKLKKDIQEEHAQRKVEIEGK 303
L+ K + + + + + +EK IE L+ S+ ++ K++I + K E E +
Sbjct: 996 LSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQ 1055
Query: 304 LEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEV-SAL 362
+ + E +A + ++ + K + E + + +E +L A+ L+NE+ + L
Sbjct: 1056 ISLLK-----EKLETATTANDENVNK--ISELTKTREELEAELA---AYKNLKNELETKL 1105
Query: 363 KSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLK 422
++ K LK+ E+ + QL+K+ + + N+LR ++ LEK E+L ++ KK +
Sbjct: 1106 ETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYE 1165
Query: 423 KDIQEEQAQRKIEI-----------EGKLEISNAFAALENEVSALKS---ESTKLKKDIL 468
+ I ++ Q EI + I LE EV A+KS E + LKK +
Sbjct: 1166 EQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEI 1225
Query: 469 EE-QAQIKVAIEEKLEISNAFAALENEVSALKSE---IAALQQKCGAGSREGNGDVEVLK 524
+ QIK +++K E + A+L + +++SE I LQ +C +E + + LK
Sbjct: 1226 DALNLQIK-ELKKKNETNE--ASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLK 1282
Query: 525 AGISDTEKEVNTLKKELVEKEKIVADSERKTA--------VDERKKAAAEARKLLEAAKK 576
A K + K E EKI + + KT + KA ++ L KK
Sbjct: 1283 ASEDKNSKYLELQK----ESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKK 1338
Query: 577 IAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKG-----------IENL 625
+ E+ E ++L+K ++ + A + K+L +G I L
Sbjct: 1339 TSSEERKNAE--------EQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTL 1390
Query: 626 ESENKKLKKENEVSA-----LKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRL 680
E E +L+ ENE+ A +SE+ + E ++ L+ I K ++ R
Sbjct: 1391 EDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRN 1450
Query: 681 KKEHVEEERIVADSERK-TAVDERKNAAAEAR-KLLEAPKKIAAEVEKQIAKVELRQVHL 738
++ + ER D++R ++ E+ AA E++ K+ E KK+ E K+ A++E + +
Sbjct: 1451 DEKLLSIER---DNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMM 1507
Query: 739 EK-----QVNERKMKLAFEL-----SKTKEATKRFEAEKKKLLVEKINAESKIKKAQE-- 786
+K + NE ++K + E K +++ K E + K L EK + S+I ++++
Sbjct: 1508 KKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDI 1567
Query: 787 -----------RSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQ 823
+S SEL+ T E A+E+ ++ ++ +L L+
Sbjct: 1568 EELKSKLRIEAKSGSELE--TVKQELNNAQEKIRINAEENTVLKSKLE 1613
Score = 129 bits (324), Expect = 3e-29
Identities = 174/843 (20%), Positives = 354/843 (41%), Gaps = 95/843 (11%)
Query: 46 IENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEE 105
I E K L+K ++ +Q+K A +G ++ AL E+ A + EN K ++ +E
Sbjct: 834 IHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQA-VEENCK---NLQKE 889
Query: 106 QAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIE 165
+ + + Q K+ + + E A +K + + +E ++ + L K+ +E ++ +E +
Sbjct: 890 KDKSNVNHQ-KETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKE-KEHISKELVEYK 947
Query: 166 GKLEK-SNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVS 224
+ + N A L ++ +L + K ++ E ++ K E K E S + L+N++
Sbjct: 948 SRFQSHDNLVAKLTEKLKSLANNYKDMQA---ENESLIKAVEESKNESSIQLSNLQNKID 1004
Query: 225 ALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKK 284
++ E + + ++ + K ++LKK + + + + + + + ES+
Sbjct: 1005 SMSQEKENFQ---IERGSIEKNIEQLKKTISDLEQTKEEI---ISKSDSSKDEYESQISL 1058
Query: 285 LKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEG 344
LK+ ++ + E++ LE E++A K+ +L+ + + K E
Sbjct: 1059 LKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKEN 1118
Query: 345 KLEISNAFAALENEVSALKSENKKLKQDILE-EQAQGKFCDQLKKKCEKVVEGRNALRQA 403
+ + LE E + K + L+ ++ E+ QLKK E++ +
Sbjct: 1119 EEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEE 1178
Query: 404 VKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL 463
+ L I + + EN+ +KK E + + K E SN ++E+ AL + +L
Sbjct: 1179 ISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNL---KKSEIDALNLQIKEL 1235
Query: 464 KKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVL 523
KK +A + +I+ + L++E + + E++ L+ K A + + +E+
Sbjct: 1236 KKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQ 1295
Query: 524 KAG--------ISDTEKEVNTLKKELVEKEKIVADSE----RKTAVDERKKAAAEARKLL 571
K TE ++ K + K K ++SE +KT+ +ERK A + KL
Sbjct: 1296 KESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLK 1355
Query: 572 EAAK----KIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLES 627
+ E+ ++ E ++ ++ E +K + L+ ++ K I+N S
Sbjct: 1356 NEIQIKNQAFEKERKLLNEGSSTITQ--EYSEKINTLEDELIRLQNENELKAKEIDNTRS 1413
Query: 628 ENKKL---------KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVN 678
E +K+ +K+N + +L+ EI + + K + E L + D K+++
Sbjct: 1414 ELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKI-------TRNDEKLLSIERDNKRDLE 1466
Query: 679 RLKKE--HVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVE----------- 725
LK++ +E + + K +E AE K E KK+ + +E
Sbjct: 1467 SLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSME 1526
Query: 726 ---KQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVE--------- 773
K K+E + E+ + + + + +S+ E+ K E K KL +E
Sbjct: 1527 TIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELET 1586
Query: 774 ------------KINAESK--IKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLG 819
+INAE +K E E EL K A+++ Q E+K+L +L L
Sbjct: 1587 VKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQ--EEKELLTSRLKELE 1644
Query: 820 DSL 822
L
Sbjct: 1645 QEL 1647
Score = 128 bits (322), Expect = 5e-29
Identities = 165/717 (23%), Positives = 331/717 (46%), Gaps = 89/717 (12%)
Query: 140 ENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQ 199
EN+ L D EE KI E + L+ E+++L++E + +++ E+
Sbjct: 706 ENIYRIRTALSHDPDEEPIS-KISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKL 764
Query: 200 ---AQRKVAMEGKLEISNA-FAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCE 255
++ K +I N+ ++L+ S L++E K ++ D LDE Q + K K
Sbjct: 765 IALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVR-DSLDEMTQLRDVLETKDKEN 823
Query: 256 K--VVEGRNALRQ---AVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAF 310
+ ++E ++ + + ++K LEKG+E + S+ KK + I + + +S
Sbjct: 824 QTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMG-------KDLFALSREM 876
Query: 311 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLE----ISNAFAALENEVSALKSEN 366
A+E L+ E K + +E K + K+ I+ ++ + + L E
Sbjct: 877 QAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEK 936
Query: 367 KKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQ 426
+ + ++++E +++ + D L K L + +K L +++++EN+ L K ++
Sbjct: 937 EHISKELVEYKSRFQSHDNLVAK----------LTEKLKSLANNYKDMQAENESLIKAVE 986
Query: 427 EEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISN 486
E + + I++ + N ++ E + E ++K+I + + I + K EI +
Sbjct: 987 ESKNESSIQLSN---LQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIIS 1043
Query: 487 AFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEK 546
+ ++E +S+I+ L++K + + +V IS+ K L+ EL +
Sbjct: 1044 KSDSSKDEY---ESQISLLKEKLETATTANDENVNK----ISELTKTREELEAELAAYKN 1096
Query: 547 IVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAV 606
+ +E +T ++ +KA E ++ E K+ EK +L+K+ +
Sbjct: 1097 L--KNELETKLETSEKALKEVKENEEHLKE---EKI-------------QLEKEATETKQ 1138
Query: 607 GRNALRQAVKILEKGIENLESENKKLKKE---------NEVSALKSEISALQQKCGAGAR 657
N+LR ++ LEK E+L ++ KK +++ E+S L EI++ QQ+ +
Sbjct: 1139 QLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQE-NESIK 1197
Query: 658 EGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAP 717
+ N ++E + T +E + LKK ++ + +K KN EA LLE+
Sbjct: 1198 KKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKK------KNETNEA-SLLESI 1250
Query: 718 KKIAAEVEKQIAKVELRQVHLEKQVNERKMKL-AFELSKTKEATKRFEAEKKKLLVEKIN 776
K + +E K I +++ EK+V+E + KL A E +K + E+EK K ++
Sbjct: 1251 KSVESETVK-IKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKT 1309
Query: 777 AESKIK--------KAQERSESELD--KKTADMEKQQAEEQKKLAEDKLLLLGDSLQ 823
E KI+ KA+E+SESEL KKT+ E++ AEEQ + ++++ + + +
Sbjct: 1310 TELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFE 1366
Score = 60.5 bits (145), Expect = 2e-08
Identities = 75/316 (23%), Positives = 139/316 (43%), Gaps = 39/316 (12%)
Query: 2 ASEKAVIPEPANCCSKCE--------ELKKKCEQVVVGRNALRQAVKILEKGIENLESEN 53
+ EKA + + K E ELK E + L Q+ K E+ I+NL+ E
Sbjct: 1494 SKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEK 1553
Query: 54 KKL-------KKDIQEEQAQRKVAIEGKLEISNTFAALEN---EVSALISENKKLKQDIL 103
L +KDI+E +++ ++ + E+ L N ++ EN LK +
Sbjct: 1554 SDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKL- 1612
Query: 104 EEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQ-RKI 162
E + ++ D+ + + E + L +K LE + L+S +K +K +E +A+ RK
Sbjct: 1613 -EDIERELKDKQAEIKSNQEEKELLTSRLKELE---QELDSTQQKAQKSEEERRAEVRKF 1668
Query: 163 EIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENE 222
++E K + LE + + L ++ + K+D E +K + EI L E
Sbjct: 1669 QVE-KSQLDEKAMLLETKYNDLVNKEQAWKRD---EDTVKKTTDSQRQEIEK----LAKE 1720
Query: 223 VSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESEN 282
+ LK+EN KLK+ D + EK + R+ K+ + G+E + S+
Sbjct: 1721 LDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRS------KLKDLGVE-ISSDE 1773
Query: 283 KKLKKDIQEEHAQRKV 298
+ ++D +E+ + +V
Sbjct: 1774 EDDEEDDEEDEEEGQV 1789
>MYS2_DICDI (P08799) Myosin II heavy chain, non muscle
Length = 2116
Score = 144 bits (364), Expect = 7e-34
Identities = 201/879 (22%), Positives = 380/879 (42%), Gaps = 109/879 (12%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL--- 75
+EL+K+ E++ + + +LEK L+SE L + E + + K
Sbjct: 978 DELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKDKSELLRQKKKLE 1037
Query: 76 -EISNTFAALENEVSALISE---NKKLKQDI--LEEQAQGKIC--DQLKKCEKVVEGR-- 125
E+ AL E +A +++ NKKL+ + L E+ ++ ++K +K +E +
Sbjct: 1038 EELKQVQEALAAETAAKLAQEAANKKLQGEYTELNEKFNSEVTARSNVEKSKKTLESQLV 1097
Query: 126 ---NALRQAVK---ILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALEN 179
N L + K LEK+ + L++ +++K ++ ++K + K+++ + AL N
Sbjct: 1098 AVNNELDEEKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRN 1157
Query: 180 EVSALKSENKKLK--KDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDI 237
++S L+S KL+ K LE + R ++G+LE A + S ++ + KK++ D+
Sbjct: 1158 QISELQSTIAKLEKIKSTLEGEVAR---LQGELE------AEQLAKSNVEKQKKKVELDL 1208
Query: 238 LDEQAQ-------GKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQ 290
D+ AQ + D+LKKK E+ E Q + K + N +S NK L+
Sbjct: 1209 EDKSAQLAEETAAKQALDKLKKKLEQ--ELSEVQTQLSEANNKNV-NSDSTNKHLETSFN 1265
Query: 291 EEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISN 350
+ + E + K + LE+E LK N++L+++ ++++ K ++ + E+S
Sbjct: 1266 NLKLELEAEQKAKQALEKKRLGLESE---LKHVNEQLEEEKKQKESNEKRKVDLEKEVSE 1322
Query: 351 AFAALENEVSALK--SENKKLKQDILEE---------QAQGKFCDQLKKKCEKVVEGRNA 399
+E EV++ K +E K K+ L+E ++ K +QLK K E RN
Sbjct: 1323 LKDQIEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNT 1382
Query: 400 LRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSE 459
+A E ++ E KK + D++E + E K++ A E + + KSE
Sbjct: 1383 AEEA----EGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSE 1438
Query: 460 STKLKKDILEEQAQIKVAIEEKLEISN--------------AFAALENEVSALKSEIAAL 505
K E+ QIK EE E+ + A E+ + +LK EI A
Sbjct: 1439 LDDAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAA 1498
Query: 506 QQKCGAGSREGNGDVEVLKAGISDT-EKEVNTLKKELVEKEKIVADSERKTAVDERKKAA 564
R+ ++EV A + ++ E + T+ E + K+ D R E +
Sbjct: 1499 NNAKAKAERKSK-ELEVRVAELEESLEDKSGTVNVEFIRKKDAEIDDLRARLDRETESRI 1557
Query: 565 AEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCE------------------KVAV 606
K+ A +A + E D LKKK E K+
Sbjct: 1558 KSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIKIEK 1617
Query: 607 GRNALRQAV---KILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDV 663
+ L Q + + E+G E + + EV L++++ + + A ++ +
Sbjct: 1618 SKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQEVDELRAQLDSERAALNASEKK----I 1673
Query: 664 EVLKAGISDTKKEVNR--LKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIA 721
+ L A + + K+++ L K+ + + + + E + D+ + +L ++ +++
Sbjct: 1674 KSLVAEVDEVKEQLEDEILAKDKLVKAKRALEVELEEVRDQLEEEEDSRSELEDSKRRLT 1733
Query: 722 AEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKI 781
EVE I K +V +++E K KL ++ K K+ E EKKK L E A+ ++
Sbjct: 1734 TEVE-DIKKKYDAEVEQNTKLDEAKKKLTDDVDTLK---KQLEDEKKK-LNESERAKKRL 1788
Query: 782 KKAQERSESELD---KKTADMEKQQAEEQKKLAEDKLLL 817
+ E ++LD K + EK + + +K L + K L
Sbjct: 1789 ESENEDFLAKLDAEVKNRSRAEKDRKKYEKDLKDTKYKL 1827
Score = 141 bits (355), Expect = 8e-33
Identities = 184/811 (22%), Positives = 364/811 (44%), Gaps = 134/811 (16%)
Query: 34 ALRQAVKILEKGIENLESENKKLK---KDIQEEQAQRKVAIEGKLEISNTFAALENEVSA 90
A ++ +K + + LE++ ++L+ +D++ E ++K+A+E + N ++E +V
Sbjct: 874 AEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALEN---LQNQKRSVEEKVRD 930
Query: 91 L---ISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENK 147
L + E +KL+ + E+ + K ++L++ ++V +G++ + LEK + L+ E +
Sbjct: 931 LEEELQEEQKLRNTL--EKLKKKYEEELEEMKRVNDGQS---DTISRLEKIKDELQKEVE 985
Query: 148 KLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAME 207
+L + EE + G LEK+ L++E+ L KD E Q+K E
Sbjct: 986 ELTESFSEESKDK-----GVLEKTRV--RLQSELDDLTVRLDSETKDKSELLRQKKKLEE 1038
Query: 208 GKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQA 267
++ A AA E +A KL Q+ +++ QG++ + +K +V N
Sbjct: 1039 ELKQVQEALAA---ETAA------KLAQEAANKKLQGEYTELNEKFNSEVTARSN----- 1084
Query: 268 VKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKL 327
+EK + LES+ + ++ EE R ALE + AL + +++
Sbjct: 1085 ---VEKSKKTLESQLVAVNNELDEEKKNRD--------------ALEKKKKALDAMLEEM 1127
Query: 328 KKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLK 387
K + ++K + K++ + AL N++S L+S KL
Sbjct: 1128 KDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQSTIAKL------------------ 1169
Query: 388 KKCEKVVEGRNA-LRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAF 446
+K + +EG A L+ ++ + N+E + KK++ D++++ AQ E K
Sbjct: 1170 EKIKSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELDLEDKSAQLAEETAAK------- 1222
Query: 447 AALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQ 506
AL KL++++ E Q Q+ A + + + LE + LK E+ A Q
Sbjct: 1223 -------QALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNKHLETSFNNLKLELEAEQ 1275
Query: 507 QKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAE 566
+ A +E + G+ K VN E +E+EK +S K VD +K +E
Sbjct: 1276 KAKQA--------LEKKRLGLESELKHVN----EQLEEEKKQKESNEKRKVD-LEKEVSE 1322
Query: 567 ARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENL- 625
+ +E +++A +KAV S+ DE+K++ V R+ + +K L+ E L
Sbjct: 1323 LKDQIE--EEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELR 1380
Query: 626 -----------ESENKKLKKENEV-SALKS--EISALQQKCGAGAREGNGDVEVLKAGIS 671
+E K K E ++ A+K+ E +A + K ++ D K+ +
Sbjct: 1381 NTAEEAEGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELD 1440
Query: 672 DTKK-------EVNRLKKEHVEEERIV--ADSERKTAVDERKNAAAEARKL---LEAPKK 719
D K ++ RL +E E ++ AD +A+ +K A + L ++A
Sbjct: 1441 DAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAANN 1500
Query: 720 IAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAES 779
A+ E++ ++E+R LE+ + ++ + E + K+A E + + +++ ES
Sbjct: 1501 AKAKAERKSKELEVRVAELEESLEDKSGTVNVEFIRKKDA----EIDDLRARLDR-ETES 1555
Query: 780 KIKKAQERSESELDKKTADMEKQQAEEQKKL 810
+IK +++ + K+ AD+E + E Q+++
Sbjct: 1556 RIKSDEDKKNTR--KQFADLEAKVEEAQREV 1584
Score = 139 bits (349), Expect = 4e-32
Identities = 196/870 (22%), Positives = 373/870 (42%), Gaps = 109/870 (12%)
Query: 13 NCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR----K 68
N S + L+ + + A ++A + LEK LESE K + + ++EE+ Q+ K
Sbjct: 1252 NSDSTNKHLETSFNNLKLELEAEQKAKQALEKKRLGLESELKHVNEQLEEEKKQKESNEK 1311
Query: 69 VAIEGKLEISNTFAALENEVSA--LISENKKLKQDILEE---------QAQGKICDQLKK 117
++ + E+S +E EV++ ++E K K+ L+E ++ K +QLK
Sbjct: 1312 RKVDLEKEVSELKDQIEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKT 1371
Query: 118 CEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAAL 177
+ E LR + E +++ E KK + D++E + E K++ A
Sbjct: 1372 LQAKNE---ELRNTAEEAEGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKA 1428
Query: 178 ENEVSALKSENKKLKKDILEEQAQ-----------RKVAMEGKLEISNAFAALENEVSAL 226
E + + KSE K E+ Q R V E ++A A + SAL
Sbjct: 1429 ETDYRSTKSELDDAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESAL 1488
Query: 227 KSENKKLKQDILDEQAQGKFCDRLKKKCE-KVVEGRNALRQAVKILEKGIENLESENKK- 284
+S LK +I +R K+ E +V E +L + G N+E KK
Sbjct: 1489 ES----LKDEIDAANNAKAKAERKSKELEVRVAELEESLED-----KSGTVNVEFIRKKD 1539
Query: 285 -----LKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSE-------NKKLKKDIL 332
L+ + E R E K FA LE +V + E KKL+ DI+
Sbjct: 1540 AEIDDLRARLDRETESRIKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDII 1599
Query: 333 EEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEK 392
+ Q + +++I + LE ++ ++ ++ + A + Q+ ++ ++
Sbjct: 1600 DLSTQLDTETKSRIKIEKSKKKLEQTLA-----ERRAAEEGSSKAADEEIRKQVWQEVDE 1654
Query: 393 VVEGRNALRQAVKILEKGIENLESENKKLKKDIQEE--------QAQRKIEIEGKLEISN 444
+ ++ R A+ EK I++L +E ++K+ +++E +A+R +E+E + E+ +
Sbjct: 1655 LRAQLDSERAALNASEKKIKSLVAEVDEVKEQLEDEILAKDKLVKAKRALEVELE-EVRD 1713
Query: 445 AFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAA 504
E+ S L+ +L ++ + + + +E+ ++ A L ++V LK ++
Sbjct: 1714 QLEEEEDSRSELEDSKRRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQLED 1773
Query: 505 LQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAA 564
++K R ++E E K + K + A+ +RK + K
Sbjct: 1774 EKKKLNESERAKKR---------LESENEDFLAKLDAEVKNRSRAEKDRKKYEKDLKDTK 1824
Query: 565 AEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIEN 624
+ EAA K E A + DEL+ K E+ ++ K LE I+N
Sbjct: 1825 YKLND--EAATKTQTEIGA----AKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEIDN 1878
Query: 625 L----ESENK-KLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNR 679
L E E K K++ E E AL+ E+ L++ A + + E K + ++ R
Sbjct: 1879 LRAQIEDEGKIKMRLEKEKRALEGELEELRETV-EEAEDSKSEAEQSKRLVELELEDARR 1937
Query: 680 LKKEHVEEERIVADS---------ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAK 730
++ ++ + I D+ E K ++E A + + + K++ AE++ A+
Sbjct: 1938 NLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDR---SRKRLEAEIDALTAQ 1994
Query: 731 VELRQVHLEKQVNERKMKLAFELSKTKEATKRF-EAEKKK----LLVEKINAESKIKKAQ 785
V+ Q +Q+ E K K+ EL KE K+F E+EK K L+VEK+ + K K +
Sbjct: 1995 VDAEQKAKNQQIKENK-KIETEL---KEYRKKFGESEKTKTKEFLVVEKLETDYKRAK-K 2049
Query: 786 ERSESELDKKTADMEKQQAEEQKKLAEDKL 815
E ++ + + T + + ++ + L +D +
Sbjct: 2050 EAADEQQQRLTVENDLRKHLSEISLLKDAI 2079
Score = 133 bits (334), Expect = 2e-30
Identities = 185/814 (22%), Positives = 362/814 (43%), Gaps = 104/814 (12%)
Query: 1 MASEKAVIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDI 60
+AS+KAV S+ +E+K++ VV R+ + +K L+ E L + ++ + +
Sbjct: 1331 VASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAEEAEGQL 1390
Query: 61 QEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEK 120
+ +K A + ++ LE E + + K +K+ + ++ D K
Sbjct: 1391 DRAERSKKKA---EFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELDDAKNVSS 1447
Query: 121 VVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENE 180
Q V +I+ L E +L+ ++E + I+ K +A +L++E
Sbjct: 1448 --------EQYV-----QIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDE 1494
Query: 181 VSA---LKSENKKLKKDILEEQAQRKVAMEGK-------------LEISNAFAALENEV- 223
+ A K++ ++ K++ A+ + ++E K EI + A L+ E
Sbjct: 1495 IDAANNAKAKAERKSKELEVRVAELEESLEDKSGTVNVEFIRKKDAEIDDLRARLDRETE 1554
Query: 224 SALKSENKK---------LKQDILDEQAQGKFCDRLKKKCEK-VVEGRNALRQAVKILEK 273
S +KS+ K L+ + + Q + DRLKKK E +++ L K K
Sbjct: 1555 SRIKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIK 1614
Query: 274 GIENLESENKKLKKDIQEEHAQRK-------VEIEGKL--EISNAFAALENEVSALKSEN 324
+E KKL++ + E A + EI ++ E+ A L++E +AL +
Sbjct: 1615 ----IEKSKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQEVDELRAQLDSERAALNASE 1670
Query: 325 KKLKK-----DILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQ 379
KK+K D ++EQ + ++ + KL A ALE E+ ++ + ++ ++D E
Sbjct: 1671 KKIKSLVAEVDEVKEQLEDEILAKDKL--VKAKRALEVELEEVRDQLEE-EEDSRSELED 1727
Query: 380 GK-----FCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQE-EQAQRK 433
K + +KKK + VE L +A K L ++ L+ + + KK + E E+A+++
Sbjct: 1728 SKRRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQLEDEKKKLNESERAKKR 1787
Query: 434 IEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALEN 493
+E E + ++ A ++N S + + K +KD+ + + ++ K + A LE+
Sbjct: 1788 LESENEDFLAKLDAEVKNR-SRAEKDRKKYEKDLKDTKYKLNDEAATKTQTEIGAAKLED 1846
Query: 494 EVSALKSEIAALQQKCGAGSREG---NGDVEVLKAGISD-------TEKEVNTLKKELVE 543
++ L+S++ Q K + G+++ L+A I D EKE L+ EL E
Sbjct: 1847 QIDELRSKLEQEQAKATQADKSKKTLEGEIDNLRAQIEDEGKIKMRLEKEKRALEGELEE 1906
Query: 544 KEKIVADSERKTAVDERKKAAAE-----ARKLLEAAKKIAPEKAVIPEPANCCSKCDELK 598
+ V ++E + E+ K E AR+ L+ K+I ++ +N + E K
Sbjct: 1907 LRETVEEAEDSKSEAEQSKRLVELELEDARRNLQ--KEIDAKEIAEDAKSNLQREIVEAK 1964
Query: 599 KKCEKVAVGRNALRQAVKILEKGIENL----ESENK-KLKKENEVSALKSEISALQQKCG 653
+ E+ ++ R ++ K LE I+ L ++E K K ++ E +++E+ ++K G
Sbjct: 1965 GRLEEESIARTNSDRSRKRLEAEIDALTAQVDAEQKAKNQQIKENKKIETELKEYRKKFG 2024
Query: 654 AGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL 713
+ + V++ +D K R KKE +E++ +R T ++ + +E L
Sbjct: 2025 ESEKTKTKEFLVVEKLETDYK----RAKKEAADEQQ-----QRLTVENDLRKHLSEISLL 2075
Query: 714 LEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKM 747
+A K+ + +K K EL K +RKM
Sbjct: 2076 KDAIDKLQRDHDK--TKRELETETASKIEMQRKM 2107
Score = 105 bits (261), Expect = 6e-22
Identities = 126/498 (25%), Positives = 237/498 (47%), Gaps = 58/498 (11%)
Query: 19 EELKKKCEQVVVGRNAL----RQAVKILEKGIENLESENKKLKKDIQEE--------QAQ 66
EE++K+ Q V A R A+ EK I++L +E ++K+ +++E +A+
Sbjct: 1642 EEIRKQVWQEVDELRAQLDSERAALNASEKKIKSLVAEVDEVKEQLEDEILAKDKLVKAK 1701
Query: 67 RKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRN 126
R + +E + E+ + E+ S L ++L ++ E + K ++++ K+ E +
Sbjct: 1702 RALEVELE-EVRDQLEEEEDSRSELEDSKRRLTTEV--EDIKKKYDAEVEQNTKLDEAKK 1758
Query: 127 ALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKS 186
L V L+K+ LE E KKL + E+A++++E E + + A ++N A K
Sbjct: 1759 KLTDDVDTLKKQ---LEDEKKKLN---ESERAKKRLESENEDFLAKLDAEVKNRSRAEK- 1811
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKF 246
+ KK +KD+ + + + K + A LE+++ L+S KL+Q EQA+
Sbjct: 1812 DRKKYEKDLKDTKYKLNDEAATKTQTEIGAAKLEDQIDELRS---KLEQ----EQAKATQ 1864
Query: 247 CDRLKKKCEKVVEGRNA-LRQAVKI---LEKGIENLESENKKLKKDIQEEHAQRKVEIEG 302
D+ KK E ++ A + KI LEK LE E ++L++ ++E + +
Sbjct: 1865 ADKSKKTLEGEIDNLRAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQS 1924
Query: 303 K----LEISNAFAALENEVSALK-SENKK--LKKDILEEQAQRKVAMEGKLEISNAFAAL 355
K LE+ +A L+ E+ A + +E+ K L+++I+E + + + + + L
Sbjct: 1925 KRLVELELEDARRNLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDRSRKRL 1984
Query: 356 ENEVSALKS----ENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGI 411
E E+ AL + E K Q I E + K +LK+ +K E + ++EK
Sbjct: 1985 EAEIDALTAQVDAEQKAKNQQIKENK---KIETELKEYRKKFGESEKTKTKEFLVVEK-- 2039
Query: 412 ENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQ 471
LE++ K+ KK+ +EQ QR L + N +E+S LK KL++D + +
Sbjct: 2040 --LETDYKRAKKEAADEQQQR-------LTVENDLRKHLSEISLLKDAIDKLQRDHDKTK 2090
Query: 472 AQIKVAIEEKLEISNAFA 489
+++ K+E+ A
Sbjct: 2091 RELETETASKIEMQRKMA 2108
Score = 98.2 bits (243), Expect = 8e-20
Identities = 152/691 (21%), Positives = 296/691 (41%), Gaps = 117/691 (16%)
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKF 246
+ + +K+I E++ + LE+ + + L+ K + ++LD Q Q K
Sbjct: 822 KRRNFEKEIKEKEREI-------LELKSNLTDSTTQKDKLEKSLKDTESNVLDLQRQLK- 873
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEI 306
K+ + + + ++AL + LE +E++ESE + K ++ Q++ E ++
Sbjct: 874 --AEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRDL 931
Query: 307 SNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSEN 366
E L++ +KLKK EE + K +G+ S+ + LE L+ E
Sbjct: 932 EEEL----QEEQKLRNTLEKLKKKYEEELEEMKRVNDGQ---SDTISRLEKIKDELQKEV 984
Query: 367 KKLKQDILEEQAQ-----------GKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENL- 414
++L + EE D L + + + ++ L + K LE+ ++ +
Sbjct: 985 EELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKDKSELLRQKKKLEEELKQVQ 1044
Query: 415 -------------ESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSEST 461
E+ NKKL+ + E + E+ + + + LE+++ A+ +E
Sbjct: 1045 EALAAETAAKLAQEAANKKLQGEYTELNEKFNSEVTARSNVEKSKKTLESQLVAVNNELD 1104
Query: 462 KLKK--DILEEQAQIKVAIEE-------------------KLEISNAFAALENEVSALKS 500
+ KK D LE++ + A+ E K++ + AL N++S L+S
Sbjct: 1105 EEKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQS 1164
Query: 501 EIAALQQKCGAGSREG-----NGDVEVLKAGISDTEKEVNTLKKELVEKE-KIVADSERK 554
IA L++ + EG G++E + S+ EK+ ++ +L +K ++ ++ K
Sbjct: 1165 TIAKLEKI--KSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELDLEDKSAQLAEETAAK 1222
Query: 555 TAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQA 614
A+D+ KK + ++ A K V + N L+ + + A ++A
Sbjct: 1223 QALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTN-----KHLETSFNNLKLELEAEQKA 1277
Query: 615 VKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTK 674
+ LEK LESE K + ++ E + E + ++ D +
Sbjct: 1278 KQALEKKRLGLESELKHVNEQLEEEKKQKESNEKRK--------------------VDLE 1317
Query: 675 KEVNRLK---KEHVEEERIVADSERK--TAVDERKNAAAEA----RKLLEAPKKIAAEVE 725
KEV+ LK +E V ++ V +++ K + +DE K A+ K +E K + A+ E
Sbjct: 1318 KEVSELKDQIEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNE 1377
Query: 726 KQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQ 785
+ E + L++ +K K F+L +EA K E E K K+ AE +KKA+
Sbjct: 1378 ELRNTAEEAEGQLDRAERSKK-KAEFDL---EEAVKNLEEETAK----KVKAEKAMKKAE 1429
Query: 786 ---ERSESELDKKTADMEKQQAEEQKKLAED 813
++SELD ++ +Q + K+L E+
Sbjct: 1430 TDYRSTKSELD-DAKNVSSEQYVQIKRLNEE 1459
>MYH9_CHICK (P14105) Myosin heavy chain, nonmuscle (Cellular myosin
heavy chain) (NMMHC)
Length = 1959
Score = 144 bits (362), Expect = 1e-33
Identities = 197/892 (22%), Positives = 403/892 (45%), Gaps = 138/892 (15%)
Query: 12 ANCCSKCEEL-------KKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQ--- 61
A C++ EE+ K++ E++ + L V+ E+ ++L++E KK++++IQ
Sbjct: 893 AELCAEAEEIRARLTAKKQELEEIC---HDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 62 -----EEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQD--ILEEQAQ---GKI 111
EE A++K+ +E K+ LE +V L +N KL ++ +LE++ +
Sbjct: 950 EQLEEEESARQKLQLE-KVTTEAKLKKLEEDVIVLEDQNLKLAKEKKLLEDRMSEFTTNL 1008
Query: 112 CDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKS 171
++ +K + + + +N + LE+R+ E + ++L E+ +RK+E + +
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL------EKTRRKLEGDSS-DLH 1061
Query: 172 NAFAALENEVSALKSENKKLKKD-------ILEEQAQRKVAMEGKLEISNAFAALENEV- 223
+ A L+ +++ LK + K +++ + EE AQ+ +A++ E+ + L+ ++
Sbjct: 1062 DQIAELQAQIAELKIQLSKKEEELQAALARVEEEAAQKNMALKKIRELESQITELQEDLE 1121
Query: 224 SALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-------RNALRQAVKILEKGIE 276
S S NK KQ ++ G+ + LK + E ++ R+ Q V +L+K +E
Sbjct: 1122 SERASRNKAEKQ----KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVTVLKKTLE 1177
Query: 277 NLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAA-LENEVSALKSENKKLKKDILEEQ 335
+ ++ ++++++H+Q E+ +LE + A LE AL+SE +L ++
Sbjct: 1178 DEAKTHEAQIQEMRQKHSQAIEELAEQLEQTKRVKANLEKAKQALESERAELSNEV---- 1233
Query: 336 AQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVE 395
KV ++GK + +E+K+ K D ++ Q KF + + K E + E
Sbjct: 1234 ---KVLLQGKGD----------------AEHKRKKVDAQLQELQVKFTEGERVKTE-LAE 1273
Query: 396 GRNALRQAVKILEKGIENLESENKKLKKD-------IQEEQAQRKIEIEGKLEISNAFAA 448
N L+ + + + +S++ KL KD +Q+ Q + E KL S
Sbjct: 1274 RVNKLQVELDNVTGLLNQSDSKSIKLAKDFSALESQLQDTQELLQEETRLKLSFSTKLKQ 1333
Query: 449 LENEVSALKS--ESTKLKKDILEEQAQI--KVAIEEKLEISNAFAALENEVSALK----- 499
E+E +ALK E + K LE+Q + + A+E + ++ + LE A K
Sbjct: 1334 TEDEKNALKEQLEEEEEAKRNLEKQISVLQQQAVEARKKMDDGLGCLEIAEEAKKKLQKD 1393
Query: 500 --------SEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADS 551
E A K +++ + + + V+ L+K+ + ++++A+
Sbjct: 1394 LESLTQRYEEKIAAYDKLEKTKTRLQQELDDIAVDLDHQRQTVSNLEKKQKKFDQLLAEE 1453
Query: 552 ERKTA--VDERKKAAAEARK-------LLEAAKKIAPEKAVI--------PEPANCCSKC 594
+ +A +ER +A AEAR+ L A ++ +KA + E + S
Sbjct: 1454 KNISAKYAEERDRAEAEAREKETKALSLARALEEAIEQKAELERVNKQFRTEMEDLMSSK 1513
Query: 595 DELKKKCEKVAVGRNALRQAVKILEKGIENLE-----SENKKLKKENEVSALKS----EI 645
D++ K ++ + AL Q V+ ++ +E LE +E+ KL+ E A+K+ ++
Sbjct: 1514 DDVGKSVHELEKAKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNQQAMKAQFDRDL 1573
Query: 646 SALQQKCGAGAREGNGDVEVLKAGISDTKKE--VNRLKKEHVEEERIVADSERKTAVDER 703
++ ++ V ++ + D +K+ + ++ +E + +S TA R
Sbjct: 1574 LGRDEQNEEKRKQLIRQVREMEVELEDERKQRSIAVAARKKLELDLKDLESHIDTANKNR 1633
Query: 704 KNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMK--------LAFELSK 755
A RKL K E+E + ++ + + NE+K+K L EL+
Sbjct: 1634 DEAIKHVRKLQAQMKDYMRELED--TRTSREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 756 TKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQ 807
+ A ++ + E+ +L E N+ K A E + L+ + A +E++ EEQ
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALAME-EKRRLEARIAQLEEELEEEQ 1742
Score = 135 bits (341), Expect = 3e-31
Identities = 180/823 (21%), Positives = 387/823 (46%), Gaps = 140/823 (17%)
Query: 50 ESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQG 109
+ E K++ + ++++A E +L TF A L++E +L++ + QA+
Sbjct: 843 QEEEMMAKEEELIKVKEKQLAAENRLSEMETFQA------QLMAEKMQLQEQL---QAEA 893
Query: 110 KICDQLK--------KCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQ------- 154
++C + + K +++ E + L V+ E+R ++L++E KK++++IQ
Sbjct: 894 ELCAEAEEIRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 155 -EEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKD--ILEEQ-AQRKVAMEGKL 210
EE A++K+++E K+ LE +V L+ +N KL K+ +LE++ ++ + +
Sbjct: 954 EEESARQKLQLE-KVTTEAKLKKLEEDVIVLEDQNLKLAKEKKLLEDRMSEFTTNLTEEE 1012
Query: 211 EISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKI 270
E S + A L+N+ A+ ++ L++ + E+ Q + ++ ++K E + L +
Sbjct: 1013 EKSKSLAKLKNKHEAMITD---LEERLRREEKQRQELEKTRRKLE---GDSSDLHDQIAE 1066
Query: 271 LEKGIENLESENKKLKKDIQ-------EEHAQRKVEIEGKLEISNAFAALENEVS---AL 320
L+ I L+ + K ++++Q EE AQ+ + ++ E+ + L+ ++ A
Sbjct: 1067 LQAQIAELKIQLSKKEEELQAALARVEEEAAQKNMALKKIRELESQITELQEDLESERAS 1126
Query: 321 KSENKKLKKDILEEQAQRKVAMEGKLEISNAFAAL----ENEVSALKSENKKLKQDILEE 376
+++ +K K+D+ EE K +E L+ + A L E EV+ LK K L+ +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVTVLK---KTLEDEAKTH 1183
Query: 377 QAQGKFCDQLKKKCEKVVEGRNALRQAVKI---LEKGIENLESENKKLKKDIQEEQAQRK 433
+AQ + +K + + E L Q ++ LEK + LESE +L ++ K
Sbjct: 1184 EAQ--IQEMRQKHSQAIEELAEQLEQTKRVKANLEKAKQALESERAELSNEV-------K 1234
Query: 434 IEIEGKLEISNAFAALENEVSALK---SESTKLKKDILEEQAQIKVAIEEKLEISNAFAA 490
+ ++GK + + ++ ++ L+ +E ++K ++ E +++V ++ + N +
Sbjct: 1235 VLLQGKGDAEHKRKKVDAQLQELQVKFTEGERVKTELAERVNKLQVELDNVTGLLNQSDS 1294
Query: 491 ----LENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEK 546
L + SAL+S++ Q+ +R LK TE E N LK++L E+E+
Sbjct: 1295 KSIKLAKDFSALESQLQDTQELLQEETRLKLSFSTKLK----QTEDEKNALKEQLEEEEE 1350
Query: 547 IVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAV 606
+ E++ +V +++ A EARK ++ + C +E KKK
Sbjct: 1351 AKRNLEKQISVLQQQ--AVEARKKMD-------------DGLGCLEIAEEAKKK------ 1389
Query: 607 GRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVL 666
L+K +E+L + +K L+ + LQQ +++ +
Sbjct: 1390 -----------LQKDLESLTQRYE--EKIAAYDKLEKTKTRLQQ-----------ELDDI 1425
Query: 667 KAGISDTKKEVNRLKKEHVEEERIVADSERKTA--VDERKNAAAEARKLLEAPKKIAAEV 724
+ ++ V+ L+K+ + ++++A+ + +A +ER A AEAR+ +A +
Sbjct: 1426 AVDLDHQRQTVSNLEKKQKKFDQLLAEEKNISAKYAEERDRAEAEAREKETKALSLARAL 1485
Query: 725 EKQI-AKVELRQVHLEKQVNERKM--------KLAFELSKTKEATKRFEAEKKKLLVEKI 775
E+ I K EL +V+ + + + K EL K K A ++ + E+ K +E++
Sbjct: 1486 EEAIEQKAELERVNKQFRTEMEDLMSSKDDVGKSVHELEKAKRALEQ-QVEEMKTQLEEL 1544
Query: 776 --------NAESKIKKAQERSESELDKKTADMEKQQAEEQKKL 810
+A+ +++ Q+ +++ D+ ++Q E++K+L
Sbjct: 1545 EDELQATEDAKLRLEVNQQAMKAQFDRDLLGRDEQNEEKRKQL 1587
Score = 119 bits (297), Expect = 4e-26
Identities = 220/956 (23%), Positives = 404/956 (42%), Gaps = 172/956 (17%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
++ EE +++C+ + + ++Q ++ LE+ +E ES +KL+ + +A+ K E +
Sbjct: 922 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDVI 981
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEK--VVEGRNALRQAVK 133
+ + L E L + ++ EE+ + K +LK + + + LR+ K
Sbjct: 982 VLEDQNLKLAKEKKLLEDRMSEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 134 I---LEKRIENLESENKKLKKDIQEEQAQ---RKIEIEGKLEKSNAFAALENEVSA---- 183
LEK LE ++ L I E QAQ KI++ K E+ A A E +A
Sbjct: 1042 QRQELEKTRRKLEGDSSDLHDQIAELQAQIAELKIQLSKKEEELQAALARVEEEAAQKNM 1101
Query: 184 -------LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVS----------AL 226
L+S+ +L++D+ E+A R A + K ++ AL+ E+ L
Sbjct: 1102 ALKKIRELESQITELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 227 KSENKK----LKQDILDEQA--QGKFCDRLKKKCEKVVEGRNALRQAVKI---LEKGIEN 277
+S+ ++ LK+ + DE + + + +K + + E L Q ++ LEK +
Sbjct: 1162 RSKREQEVTVLKKTLEDEAKTHEAQIQEMRQKHSQAIEELAEQLEQTKRVKANLEKAKQA 1221
Query: 278 LESENKKLKKDIQ--------EEHAQRKVEI----------EG---KLEISNAFAALENE 316
LESE +L +++ EH ++KV+ EG K E++ L+ E
Sbjct: 1222 LESERAELSNEVKVLLQGKGDAEHKRKKVDAQLQELQVKFTEGERVKTELAERVNKLQVE 1281
Query: 317 VSALK-------SENKKLKKDI--LEEQAQ--RKVAMEG---KLEISNAFAALENEVSAL 362
+ + S++ KL KD LE Q Q +++ E KL S E+E +AL
Sbjct: 1282 LDNVTGLLNQSDSKSIKLAKDFSALESQLQDTQELLQEETRLKLSFSTKLKQTEDEKNAL 1341
Query: 363 KSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLK 422
K + ++ EE+A+ Q+ ++ VE R + + LE E KKL+
Sbjct: 1342 KEQLEE------EEEAKRNLEKQISVLQQQAVEARKKMDDGLGCLEIA----EEAKKKLQ 1391
Query: 423 KDIQE--EQAQRKIEIEGKLE---------ISNAFAALENEVSALKSESTKLKK--DILE 469
KD++ ++ + KI KLE + + L+++ + + K KK +L
Sbjct: 1392 KDLESLTQRYEEKIAAYDKLEKTKTRLQQELDDIAVDLDHQRQTVSNLEKKQKKFDQLLA 1451
Query: 470 EQAQIKVAIEEKLEISNAFAALENEVSALKSEIA---ALQQKCGAG--SREGNGDVEVLK 524
E+ I E+ + + A A E E AL A A++QK +++ ++E L
Sbjct: 1452 EEKNISAKYAEERDRAEA-EAREKETKALSLARALEEAIEQKAELERVNKQFRTEMEDLM 1510
Query: 525 AGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK---KAAAEARKLLEA---AKKIA 578
+ D K V+ L+K E+ V E KT ++E + +A +A+ LE A K
Sbjct: 1511 SSKDDVGKSVHELEKAKRALEQQV--EEMKTQLEELEDELQATEDAKLRLEVNQQAMKAQ 1568
Query: 579 PEKAVIPEPANCCSKCDELKKKCEKVAVG-------RNALRQAVKILEKGIENLESENKK 631
++ ++ K +L ++ ++ V R+ A K LE +++LES
Sbjct: 1569 FDRDLLGRDEQNEEKRKQLIRQVREMEVELEDERKQRSIAVAARKKLELDLKDLESHIDT 1628
Query: 632 LKKENEVSALKSEISALQQKCGAGARE----GNGDVEVLKAGISDTKK------EVNRLK 681
K N A+K + LQ + RE E+L + KK E+ +L+
Sbjct: 1629 ANK-NRDEAIK-HVRKLQAQMKDYMRELEDTRTSREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 682 KEHVEEERIV--ADSERKTAVDERKNAAAEARKLLEAPKKIAA-------EVEKQIAKVE 732
+E ER A ER DE N++ + +E +++ A E+E++ E
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALAMEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 733 LRQVHLEK---QVNERKMKLAFELS---KTKEATKRFEAEKKKL---------------- 770
+ L+K Q+++ L E S K + A ++ E + K+L
Sbjct: 1747 IINDRLKKANLQIDQMNADLNAERSNAQKNENARQQMERQNKELKLKLQEMESAVKSKYK 1806
Query: 771 ------------LVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDK 814
L E+++ E+K ++A + +KK D+ Q +E++ + K
Sbjct: 1807 ATITALEAKIVQLEEQLDMETKERQAASKQVRRAEKKLKDILLQVDDERRNAEQFK 1862
Score = 107 bits (267), Expect = 1e-22
Identities = 157/751 (20%), Positives = 334/751 (43%), Gaps = 91/751 (12%)
Query: 21 LKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNT 80
L+K + + R L VK+L +G + E + KK+ +QE Q + K E++
Sbjct: 1215 LEKAKQALESERAELSNEVKVLLQGKGDAEHKRKKVDAQLQELQVKFTEGERVKTELAER 1274
Query: 81 FAALENE---VSALI----SENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVK 133
L+ E V+ L+ S++ KL +D + QL+ +++++ L+ +
Sbjct: 1275 VNKLQVELDNVTGLLNQSDSKSIKLAKDF------SALESQLQDTQELLQEETRLKLS-- 1326
Query: 134 ILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKK 193
+++ E E LK+ ++EE+ ++ LE ++S L+ + + +K
Sbjct: 1327 -FSTKLKQTEDEKNALKEQLEEEEEAKR--------------NLEKQISVLQQQAVEARK 1371
Query: 194 DILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKK 253
+ + ++A E K ++ +L + E K D L+ K RL+++
Sbjct: 1372 KMDDGLGCLEIAEEAKKKLQKDLESLTQ-----RYEEKIAAYDKLE-----KTKTRLQQE 1421
Query: 254 CEKVVEGRNALRQAVKILE---KGIENLESENKKLKKDIQEEHAQRKVEIEGK----LEI 306
+ + + RQ V LE K + L +E K + EE + + E K L +
Sbjct: 1422 LDDIAVDLDHQRQTVSNLEKKQKKFDQLLAEEKNISAKYAEERDRAEAEAREKETKALSL 1481
Query: 307 SNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSEN 366
+ A + + L+ NK+ + ++ + + + + E+ A ALE +V +K++
Sbjct: 1482 ARALEEAIEQKAELERVNKQFRTEMEDLMSSKDDVGKSVHELEKAKRALEQQVEEMKTQL 1541
Query: 367 KKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQ 426
++L +D L+ K ++ ++ K R+ L + + EK + L + ++++ +++
Sbjct: 1542 EEL-EDELQATEDAKLRLEVNQQAMKAQFDRDLLGRDEQNEEKR-KQLIRQVREMEVELE 1599
Query: 427 EEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEE------ 480
+E+ QR I + + ++ LE+ + + K + + QAQ+K + E
Sbjct: 1600 DERKQRSIAVAARKKLELDLKDLESHIDTANKNRDEAIKHVRKLQAQMKDYMRELEDTRT 1659
Query: 481 -KLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKK 539
+ EI E ++ ++++E+ LQ++ A R +++ +
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAER---------------AKRQAQQERD 1704
Query: 540 ELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAP-EKAVIPEPANCCSKCDELK 598
EL ++ +A+S K A+ A E ++ LEA +IA E+ + E N D LK
Sbjct: 1705 ELADE---IANSSGKGAL------AMEEKRRLEA--RIAQLEEELEEEQGNTEIINDRLK 1753
Query: 599 K---KCEKVAVGRNALRQAVKILEKGIENLESENK--KLKKENEVSALKSEISALQQKCG 653
K + +++ NA R + E + +E +NK KLK + SA+KS+ A
Sbjct: 1754 KANLQIDQMNADLNAERSNAQKNENARQQMERQNKELKLKLQEMESAVKSKYKATITALE 1813
Query: 654 AGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL 713
A + +++ K+V R +K+ +++ + D ER+ A ++ K+ A +A
Sbjct: 1814 AKIVQLEEQLDMETKERQAASKQVRRAEKK-LKDILLQVDDERRNA-EQFKDQADKANMR 1871
Query: 714 LEAPKKIAAEVEKQIAKVELRQVHLEKQVNE 744
L+ K+ E E++ + +R+ L++++++
Sbjct: 1872 LKQLKRQLEEAEEEAQRANVRR-KLQRELDD 1901
Score = 91.7 bits (226), Expect = 7e-18
Identities = 137/646 (21%), Positives = 290/646 (44%), Gaps = 93/646 (14%)
Query: 19 EELKKKCE-QVVVGRNALRQAVKILEKGI---ENLESENKKLKKDIQE--EQAQRKVAIE 72
EE K+ E Q+ V + +A K ++ G+ E E KKL+KD++ ++ + K+A
Sbjct: 1349 EEAKRNLEKQISVLQQQAVEARKKMDDGLGCLEIAEEAKKKLQKDLESLTQRYEEKIAAY 1408
Query: 73 GKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAV 132
KLE + T L+ E+ + + +Q + + + K DQL EK + + A +
Sbjct: 1409 DKLEKTKT--RLQQELDDIAVDLDHQRQTVSNLEKKQKKFDQLLAEEKNISAKYAEERDR 1466
Query: 133 KILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLK 192
E R E E K L E+A IE + +LE+ N E+ L S +
Sbjct: 1467 AEAEAR----EKETKALSLARALEEA---IEQKAELERVN--KQFRTEMEDLMSSKDDVG 1517
Query: 193 KDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKK 252
K + E + ++ + E+ LE+E+ A +E+ KL+ ++ + + +F L
Sbjct: 1518 KSVHELEKAKRALEQQVEEMKTQLEELEDELQA--TEDAKLRLEVNQQAMKAQFDRDLLG 1575
Query: 253 KCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAA 312
+ E+ E R L + V ++++ ++++E QR + + + ++
Sbjct: 1576 RDEQNEEKRKQLIRQV--------------REMEVELEDERKQRSIAVAARKKLELDLKD 1621
Query: 313 LENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ- 371
LE+ + + K + + QAQ K M E+ + + E ++ K KKLK
Sbjct: 1622 LESHIDTANKNRDEAIKHVRKLQAQMKDYMR---ELEDTRTSREEILAQAKENEKKLKSM 1678
Query: 372 --DILEEQAQGKFCDQLKKKCEKVVE------GRNALRQAVKILEKGIENLESENKKLKK 423
++++ Q + ++ K++ ++ + ++ + A+ + EK LE+ +L++
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAMEEK--RRLEARIAQLEE 1736
Query: 424 DIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLE 483
+++EEQ +I I +L+ +N ++ + L +E + +K+ Q + E KL+
Sbjct: 1737 ELEEEQGNTEI-INDRLKKAN--LQIDQMNADLNAERSNAQKNENARQQMERQNKELKLK 1793
Query: 484 ISNAFAALENE----VSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKK 539
+ +A++++ ++AL+++I L+++ ++E K+V +K
Sbjct: 1794 LQEMESAVKSKYKATITALEAKIVQLEEQLDMETKERQA-----------ASKQVRRAEK 1842
Query: 540 ELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKK 599
+L + + D ER+ A ++ K A +A L+ K+ + +E ++
Sbjct: 1843 KL-KDILLQVDDERRNA-EQFKDQADKANMRLKQLKR----------------QLEEAEE 1884
Query: 600 KCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEI 645
+ ++ V R R+ L+ E ++ N+ EVS+LKS++
Sbjct: 1885 EAQRANVRRKLQRE----LDDATETADAMNR------EVSSLKSKL 1920
>MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular
myosin heavy chain, type A) (Nonmuscle myosin heavy
chain-A) (NMMHC-A)
Length = 1961
Score = 140 bits (354), Expect = 1e-32
Identities = 190/889 (21%), Positives = 403/889 (44%), Gaps = 124/889 (13%)
Query: 15 CSKCEEL-------KKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ- 66
C++ EEL K++ E++ + L V+ E+ + L++E KK++++IQE + Q
Sbjct: 896 CAEAEELRARLTAKKQELEEIC---HDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQL 952
Query: 67 ------------RKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQ 114
KV E KL+ + + + +++ KKL +D + E + ++
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTT-DLMEE 1011
Query: 115 LKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAF 174
+K + + + +N + LE+R+ E + ++L E+ +RK+E + + S+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL------EKTRRKLEGD-STDLSDQI 1064
Query: 175 AALENEVSALKSENKKLKKD-------ILEEQAQRKVAMEGKLEISNAFAALENEVS--- 224
A L+ +++ LK + K +++ + EE AQ+ +A++ E+ + L+ ++
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESER 1124
Query: 225 ALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-------RNALRQAVKILEKGIEN 277
A +++ +K K+D+ G+ + LK + E ++ R+ Q V IL+K +E+
Sbjct: 1125 ACRNKAEKQKRDL------GEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLED 1178
Query: 278 LESENKKLKKDIQEEHAQRKVEIEGKLE--------ISNAFAALENEVSALKSENKKLKK 329
++ ++++++H+Q E+ +LE + A LENE L +E K L +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQ 1238
Query: 330 DILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKK 389
+ + +RK E+ F+ E + L + KL+ +E + +Q K
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVSKLQ---VELDSVTGLLNQSDSK 1295
Query: 390 CEKVVEGRNALRQAVKILEKGIENLESENK-KLK-----KDIQEEQAQRKIEIEGKLEIS 443
K+ + +AL L+ E L+ EN+ KL K +++E+ + ++E + E
Sbjct: 1296 SSKLTKDFSALESQ---LQDTQELLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEE-- 1350
Query: 444 NAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIA 503
A LE +++ L ++ T +KK + + ++ A E K + L + E
Sbjct: 1351 EAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQRL----EEKV 1406
Query: 504 ALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERK 561
A K +++ L + + V+ L+K+ + ++++A+ + +A +ER
Sbjct: 1407 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERD 1466
Query: 562 KAAAEARK-------LLEAAKKIAPEKAVI--------PEPANCCSKCDELKKKCEKVAV 606
+A AEAR+ L A ++ +KA + E + S D++ K ++
Sbjct: 1467 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1526
Query: 607 GRNALRQAVKILEKGIENLE-----SENKKLKKENEVSALKSEISALQQKCGAGAREGNG 661
AL Q V+ ++ +E LE +E+ KL+ E + A+K++ R+ G
Sbjct: 1527 SNRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE----------RDLQG 1576
Query: 662 DVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL---LEAPK 718
E + ++V ++ E +E+ER +R A+ RK + + L ++
Sbjct: 1577 RDEQSEEKKKQLVRQVREMEAE-LEDER----KQRSIAMAARKKLEMDLKDLEAHIDTAN 1631
Query: 719 KIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL--LVEKIN 776
K E KQ+ K++ + + V++ + L++ KE K+ ++ + ++ L E++
Sbjct: 1632 KNREEAIKQLRKLQAQMKDCMRDVDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1691
Query: 777 AESKIKKAQERSESELDKKTADMEKQ--QAEEQKKLAEDKLLLLGDSLQ 823
A + K+ ++ EL + A+ + A E+K+ E + LL + L+
Sbjct: 1692 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEALIALLEEELE 1740
Score = 131 bits (329), Expect = 8e-30
Identities = 183/831 (22%), Positives = 374/831 (44%), Gaps = 149/831 (17%)
Query: 46 IENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEE 105
+ ++ E++ L K+ + + + K L N +E S L++E +L++ +
Sbjct: 838 LNSIRHEDELLAKEAELTKVREK-----HLAAENRLTEMETMQSQLMAEKLQLQEQL--- 889
Query: 106 QAQGKICDQLK--------KCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQ 157
QA+ ++C + + K +++ E + L V+ E+R + L++E KK++++IQE +
Sbjct: 890 QAKTELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELE 949
Query: 158 AQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKD-ILEEQAQRKVAMEGKLEISNAF 216
Q + E+ +A L+ E +++ KKL++D I+ E K+A E KL
Sbjct: 950 EQLE-------EEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKL------ 996
Query: 217 AALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIE 276
LE+ V+ + D+++E+ + K +LK K E ++ L + ++ EK +
Sbjct: 997 --LEDRVA-------EFTTDLMEEEEKSKSLAKLKNKHEAMI---TDLEERLRREEKQRQ 1044
Query: 277 NLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKD------ 330
LE +KL+ D ++S+ A L+ +++ LK + K +++
Sbjct: 1045 ELEKTRRKLEGD--------------STDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 331 -ILEEQAQRKVAMEGKLEISNAFAALENEVS---ALKSENKKLKQDILEEQAQGKFCDQL 386
+ EE AQ+ +A++ E+ + L+ ++ A +++ +K K+D+ EE + L
Sbjct: 1091 RVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQKRDLGEE------LEAL 1144
Query: 387 KKKCEKVVEG-------RNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGK 439
K + E ++ R+ Q V IL+K +E+ ++ ++++++ +Q E+ +
Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 440 LE---------------ISNAFAALENEVSAL---KSESTKLKKDILEEQAQIKVAIEEK 481
LE + N L NEV AL K +S +K + + +++V E
Sbjct: 1205 LEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQVKFSEG 1264
Query: 482 LEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTE---KEVNTLK 538
+ A +++ + L + + S + D L++ + DT+ +E N K
Sbjct: 1265 ERVRTELADKVSKLQVELDSVTGLLNQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 539 KELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELK 598
L K K + D E+ + ++ ++ EA++ LE K+IA A + ++K
Sbjct: 1325 LSLSTKLKQMED-EKNSFREQLEEEEEEAKRNLE--KQIATLHAQV----------TDMK 1371
Query: 599 KKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSA---LKSEISALQQKCGAG 655
KK E +A + L+K +E L + E +V+A L+ + LQQ
Sbjct: 1372 KKMEDGVGCLETAEEAKRRLQKDLEGLSQ-----RLEEKVAAYDKLEKTKTRLQQ----- 1421
Query: 656 AREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTA--VDERKNAAAEARKL 713
+++ L + ++ V+ L+K+ + ++++A+ + +A +ER A AEAR+
Sbjct: 1422 ------ELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1475
Query: 714 LEAPKKIAAEVEKQI-AKVELRQVHLEKQVNERKM--------KLAFELSKTKEATKRFE 764
+A +E+ + K EL +++ + + + K EL K+ A ++
Sbjct: 1476 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSNRALEQQV 1535
Query: 765 AEKKKLLVEKINAESKIKKAQERSESELDKKTADMEK------QQAEEQKK 809
E K L E + + A+ R E L A E+ +Q+EE+KK
Sbjct: 1536 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1586
Score = 124 bits (311), Expect = 1e-27
Identities = 210/984 (21%), Positives = 424/984 (42%), Gaps = 191/984 (19%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
++ EE +++C+ + + ++Q ++ LE+ +E ES +KL+ + +A+ K E ++
Sbjct: 922 ARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQI 981
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEK--VVEGRNALRQAVK 133
+ + L E L + D++EE+ + K +LK + + + LR+ K
Sbjct: 982 IMEDQNCKLAKEKKLLEDRVAEFTTDLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 134 I---LEKRIENLESENKKLKKDIQEEQAQ----------RKIEIEGKLEKSNAFAALEN- 179
LEK LE ++ L I E QAQ ++ E++ L + AA +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 180 ---EVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVS----------AL 226
++ L+++ +L++D+ E+A R A + K ++ AL+ E+ L
Sbjct: 1102 ALKKIRELETQISELQEDLESERACRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 227 KSENKK----LKQDILDEQA--QGKFCDRLKKKCEKVVEGRNALRQAVKI---LEKGIEN 277
+S+ ++ LK+ + DE + + + +K + V E L Q ++ LEK +
Sbjct: 1162 RSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKATLEKAKQT 1221
Query: 278 LESENKKLKKDIQ--------EEHAQRKVEI----------EG---KLEISNAFAALENE 316
LE+E +L +++ EH ++KVE EG + E+++ + L+ E
Sbjct: 1222 LENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVSKLQVE 1281
Query: 317 VSALK-------SENKKLKKD-------------ILEEQAQRKVAMEGKL---------- 346
+ ++ S++ KL KD +L+E+ ++K+++ KL
Sbjct: 1282 LDSVTGLLNQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSF 1341
Query: 347 ------EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEG---- 396
E A LE +++ L ++ +K+ + + + ++ K++ +K +EG
Sbjct: 1342 REQLEEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQR 1401
Query: 397 --------------RNALRQAVKIL-------EKGIENLESENKKLKKDIQEEQA----- 430
+ L+Q + L + + NLE + KK + + EE+
Sbjct: 1402 LEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKY 1461
Query: 431 ---QRKIEIEGKLEISNAFA---ALENEVSALKSESTKLKK-------DILEEQAQIKVA 477
+ + E E + + + A + ALE E K+E +L K D++ + + +
Sbjct: 1462 AEERDRAEAEAREKETKALSLARALE-EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1520
Query: 478 IEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEV-LKAGISDTEKEVNT 536
+ E LE SN ALE +V +K+++ L+ + A + + +EV L+A + E+++
Sbjct: 1521 VHE-LEKSNR--ALEQQVEEMKTQLEELEDELQA-TEDAKLRLEVNLQAMKAQFERDLQG 1576
Query: 537 LKKELVEKEKIVADSERKTAV---DERKKA--AAEARKLLEAAKK--------------- 576
++ EK+K + R+ DERK+ A ARK LE K
Sbjct: 1577 RDEQSEEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREE 1636
Query: 577 -IAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE-----SENK 630
I + + + +C D+ + E++ + +K +E + L+ +E
Sbjct: 1637 AIKQLRKLQAQMKDCMRDVDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1696
Query: 631 KLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEV--------NRLKK 682
K + + E L EI+ K GA A E +E L A + + +E +RLKK
Sbjct: 1697 KRQAQQERDELADEIANSSGK-GALALEEKRRLEALIALLEEELEEEQGNTELINDRLKK 1755
Query: 683 EHVEEERIVAD----------SERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVE 732
+++ ++I D +E ER+N +A KL E + ++ + IA +E
Sbjct: 1756 ANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKA-KLQEMESAVKSKYKASIAALE 1814
Query: 733 LRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESEL 792
+ LE+Q++ + + + A K+ + ++ E+ NAE + K +++ + L
Sbjct: 1815 AKIAQLEEQLDNETKERQAASKQVRRAEKKLKDVLLQVEDERRNAE-QFKDQADKASTRL 1873
Query: 793 DKKTADMEKQQAEEQKKLAEDKLL 816
+ +E+ + E Q+ A + L
Sbjct: 1874 KQLKRQLEEAEEEAQRANASRRKL 1897
Score = 108 bits (270), Expect = 6e-23
Identities = 154/708 (21%), Positives = 319/708 (44%), Gaps = 117/708 (16%)
Query: 128 LRQAVKILEKRIENLESENKKLKKDIQEEQAQ-RKIEIEGKLEKSNAFAALENEVSALKS 186
L + ++ + R ++L +EN+ + + + Q K++++ +L+ A E+ A +
Sbjct: 848 LAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTELCAEAEELRARLT 907
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDI--LDEQAQG 244
K+ ++I + +E ++E E L++E KK++Q+I L+EQ +
Sbjct: 908 AKKQELEEICHD-------LEARVEEE------EERCQYLQAEKKKMQQNIQELEEQLEE 954
Query: 245 KFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKD---IQEEHAQRKVEIE 301
+ R K + EKV +K LE+ +E +N KL K+ +++ A+ ++
Sbjct: 955 EESARQKLQLEKVTT-----EAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTDLM 1009
Query: 302 GKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSA 361
+ E S + A L+N+ A+ ++ L++ + E+ QR+ + + ++ L ++++
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITD---LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 362 LKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL 421
L+++ +LK + +++ ++L+ +V E A+K I LE++ +L
Sbjct: 1067 LQAQIAELKMQLAKKE------EELQAALARVEEEAAQKNMALK----KIRELETQISEL 1116
Query: 422 KKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEK 481
++D++ E+A R + K ++ E+ ALK+E L+ + AQ ++ + +
Sbjct: 1117 QEDLESERACRNKAEKQKRDLGE-------ELEALKTE---LEDTLDSTAAQQELRSKRE 1166
Query: 482 LEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKEL 541
E+S LE+E +++I ++QK E +E K + EK TL+ E
Sbjct: 1167 QEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKATLEKAKQTLENER 1226
Query: 542 VEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKC 601
E V + E K+ EA +L E K + + V E A+ K +L+ +
Sbjct: 1227 GELANEVKALLQGKGDSEHKRKKVEA-QLQELQVKFSEGERVRTELAD---KVSKLQVEL 1282
Query: 602 EKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNG 661
+ V G+ N +S++K K + SAL+S++ Q
Sbjct: 1283 DSVT---------------GLLN-QSDSKSSKLTKDFSALESQLQDTQ------------ 1314
Query: 662 DVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIA 721
+ +E NR K ++ S + +++ KN+ E +L E ++
Sbjct: 1315 ----------ELLQEENRQK---------LSLSTKLKQMEDEKNSFRE--QLEEEEEEAK 1353
Query: 722 AEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL---LVEKINAE 778
+EKQIA + + ++K++ + L +EA +R + + + L L EK+ A
Sbjct: 1354 RNLEKQIATLHAQVTDMKKKMEDG----VGCLETAEEAKRRLQKDLEGLSQRLEEKVAAY 1409
Query: 779 SKIKKAQERSESELD----------KKTADMEKQQAEEQKKLAEDKLL 816
K++K + R + ELD + +++EK+Q + + LAE+K +
Sbjct: 1410 DKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTI 1457
Score = 104 bits (259), Expect = 1e-21
Identities = 145/677 (21%), Positives = 307/677 (44%), Gaps = 89/677 (13%)
Query: 42 LEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSA----LISENKK 97
L K LES+ + ++ +QEE Q KL +S +E+E ++ L E ++
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENRQ-------KLSLSTKLKQMEDEKNSFREQLEEEEEE 1351
Query: 98 LKQDILEEQA--QGKICDQLKKCEKVV-------EGRNALRQAVKILEKRIENLESENKK 148
K+++ ++ A ++ D KK E V E + L++ ++ L +R+E + K
Sbjct: 1352 AKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQRLEEKVAAYDK 1411
Query: 149 LKKD---IQEE----------QAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDI 195
L+K +Q+E Q Q +E K +K + A E +SA +E ++D
Sbjct: 1412 LEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAE----ERDR 1467
Query: 196 LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCE 255
E +A+ K L ++ A + + L+ NK+ + ++ D + D + K
Sbjct: 1468 AEAEAREKETKA--LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK---DDVGKSVH 1522
Query: 256 KVVEGRNALRQAVKILEKGIENLESENK-------KLKKDIQEEHAQRKVEIEGKLEISN 308
++ + AL Q V+ ++ +E LE E + +L+ ++Q AQ + +++G+ E S
Sbjct: 1523 ELEKSNRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS- 1581
Query: 309 AFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKK 368
E + L + ++++ ++ +E+ QR +AM + ++ LE + ++
Sbjct: 1582 -----EEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREE 1636
Query: 369 LKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDI--- 425
+ + + QAQ K C + + R + K EK ++++E+E +L++++
Sbjct: 1637 AIKQLRKLQAQMKDC---MRDVDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1693
Query: 426 ---QEEQAQRKIEIEGKLEISNAFAALE-NEVSALKSESTKLKKDILEEQAQIKVAIEEK 481
+ + Q + E+ ++ S+ AL E L++ L++++ EEQ ++ I ++
Sbjct: 1694 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEALIALLEEELEEEQGNTEL-INDR 1752
Query: 482 LEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNT-LKKE 540
L+ +N ++ + L E + Q+ A + + E LKA + + E V + K
Sbjct: 1753 LKKAN--LQIDQINTDLNLERSHAQKNENARQQLERQNKE-LKAKLQEMESAVKSKYKAS 1809
Query: 541 LVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKK 600
+ E +A E + +E K+ A ++++ A KK+ K V+ + + ++ K +
Sbjct: 1810 IAALEAKIAQLEEQLD-NETKERQAASKQVRRAEKKL---KDVLLQVEDERRNAEQFKDQ 1865
Query: 601 CEKVAVGRNALRQAVKILEKGIENLESENKKLKKENE-----VSALKSEISALQQKCGAG 655
+K + L++ ++ E+ + + +KL++E E A+ E+S+L+ K G
Sbjct: 1866 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRG 1925
Query: 656 ----------AREGNGD 662
R+G GD
Sbjct: 1926 DMPFVVTRRIVRKGTGD 1942
Score = 47.4 bits (111), Expect = 2e-04
Identities = 50/211 (23%), Positives = 100/211 (46%), Gaps = 38/211 (18%)
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGD----VEVLKAGISDTKKEVNRLKKE----H 684
K++ +++A+K LQ+ C A R N +K ++ + E L KE
Sbjct: 801 KRQQQLTAMK----VLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIRHEDELLAKEAELTK 856
Query: 685 VEEERIVADS---ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKV-----ELRQV 736
V E+ + A++ E +T + + ++ L+A ++ AE E+ A++ EL ++
Sbjct: 857 VREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTELCAEAEELRARLTAKKQELEEI 916
Query: 737 --HLEKQVNER----------KMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKA 784
LE +V E K K+ + + +E + E+ ++KL +EK+ E+K+KK
Sbjct: 917 CHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL 976
Query: 785 QERSESELDKKTADMEKQQAEEQKKLAEDKL 815
+E D+ + + + ++KKL ED++
Sbjct: 977 EE------DQIIMEDQNCKLAKEKKLLEDRV 1001
>MYSS_CYPCA (Q90339) Myosin heavy chain, fast skeletal muscle
Length = 1935
Score = 139 bits (351), Expect = 2e-32
Identities = 181/786 (23%), Positives = 369/786 (46%), Gaps = 105/786 (13%)
Query: 82 AALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIEN 141
A E E++A+ +K+K+D+ + A+ K ++ K +++ +N L+ V
Sbjct: 844 AETEKEMAAMKENYEKMKEDLTKALAKKKELEE--KMVSLLQEKNDLQLQV--------T 893
Query: 142 LESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSA--------LKSENKKLKK 193
ESEN ++ E + KI++E KL+++N E E++A L+ E +LKK
Sbjct: 894 AESENLSDAEERCEGLIKSKIQLEAKLKETNERLEDEEEINAELTAKKRKLEDECSELKK 953
Query: 194 DI------LEEQAQRKVAMEGKLE-ISNAFAALENEVSALKSENKKLKQDILDEQAQGKF 246
DI L + + K A E K++ ++ A+ + ++ L E K L ++A +
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKLTKEKKAL------QEAHQQT 1007
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLE---SENKKLKKDIQEEHAQRKVEIEGK 303
D L+ + +KV N L +A LE+ +++LE + KKL+ D+ E A+RK+E + K
Sbjct: 1008 LDDLQAEEDKV----NTLTKAKTKLEQQVDDLEGSLEQEKKLRMDL--ERAKRKLEGDLK 1061
Query: 304 LEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK 363
L + LENE +S+ K KKD Q K+ E L A L+ ++ L+
Sbjct: 1062 L-AQESIMDLENEKQ--QSDEKIKKKDFEISQLLSKIEDEQSLG-----AQLQKKIKELQ 1113
Query: 364 SENKKLKQDILEEQA--------QGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLE 415
+ ++L+++I E+A + +L++ E++ E A +++ +K E
Sbjct: 1114 ARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKK----RE 1169
Query: 416 SENKKLKKDIQEEQAQRKIEIEG-KLEISNAFAALENEVSALKSESTKLKKDILEEQAQI 474
+E +K+++D++E Q + + E +++ A L ++ L+ KL+K+ E + +I
Sbjct: 1170 AEFQKMRRDLEESTLQHEATAAALRKEQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEI 1229
Query: 475 KVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEV 534
++ A A LE L+ +++ ++ K R+ N D+ +A + + E
Sbjct: 1230 DDLTSNMEAVAKAKANLEKMCRTLEDQLSEIKTKSDENVRQLN-DMNAQRARL---QTEN 1285
Query: 535 NTLKKELVEKEKIVADSER-KTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSK 593
++L EKE +V+ R K A ++ E ++ +E +++ + A+ +
Sbjct: 1286 GEFSRQLEEKEALVSQLTRGKQAYTQQ---IEELKRHIE--EEVKAKNALAHAVQSARHD 1340
Query: 594 CDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALK--SEISALQQK 651
CD L+++ E+ ++A L++G+ SE + + + E A++ E+ ++K
Sbjct: 1341 CDLLREQYEEE-------QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 652 CGAGAREGNGDVEVLKAGISDTKKEVNRLKKE----HVEEER---IVADSERK-----TA 699
++ +E + + + +K RL+ E ++ ER + A+ ++K
Sbjct: 1394 LAQRLQDAEESIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANSLAANLDKKQRNFDKV 1453
Query: 700 VDERKNAAAEARKLLEAPKKIAAEVEKQIAKV----ELRQVHLE------KQVNERKMKL 749
+ E K E++ LE +K A + ++ K+ E HLE K + + L
Sbjct: 1454 LAEWKQKYEESQAELEGAQKEARSLSTELFKMKNSYEEALDHLETLKRENKNLQQEISDL 1513
Query: 750 AFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQ---ERSESELDKKTADMEKQQAEE 806
+L +T ++ E KK + EK ++ +++A+ E ES++ + ++ + ++E
Sbjct: 1514 TEQLGETGKSIHELEKAKKTVESEKSEIQTALEEAEGTLEHEESKILRVQLELNQVKSEI 1573
Query: 807 QKKLAE 812
+KLAE
Sbjct: 1574 DRKLAE 1579
Score = 133 bits (334), Expect = 2e-30
Identities = 171/825 (20%), Positives = 358/825 (42%), Gaps = 88/825 (10%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E + I + ++K E +
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKLTKEKKALQEAHQQ 1006
Query: 77 ISNTFAALENEVSALISENKKLKQ--DILEE--QAQGKICDQLKKCEKVVEGRNALRQAV 132
+ A E++V+ L KL+Q D LE + + K+ L++ ++ +EG L Q
Sbjct: 1007 TLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE- 1065
Query: 133 KILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKL---------EKSNAFAALENEVSA 183
I++ E +S+ K KKD + Q KIE E L E LE E+ A
Sbjct: 1066 SIMDLENEKQQSDEKIKKKDFEISQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEA 1125
Query: 184 LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE--Q 241
++ K++K + + + E E A AA ++E +K+++D+ + Q
Sbjct: 1126 ERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKMRRDLEESTLQ 1185
Query: 242 AQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIE 301
+ K++ + V E L + + L++ + LE E + K +I + + + +
Sbjct: 1186 HEATAAALRKEQADSVAE----LGEQIDNLQRVKQKLEKEKSEYKMEIDDLTSNMEAVAK 1241
Query: 302 GKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNA-FAALENEVS 360
K + LE+++S +K+++ + + + + AQR +L+ N F+ E
Sbjct: 1242 AKANLEKMCRTLEDQLSEIKTKSDENVRQLNDMNAQR-----ARLQTENGEFSRQLEEKE 1296
Query: 361 ALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKK 420
AL S+ + KQ ++ ++LK+ E+ V+ +NAL AV ++ +
Sbjct: 1297 ALVSQLTRGKQAYTQQ------IEELKRHIEEEVKAKNALAHAV-------QSARHDCDL 1343
Query: 421 LKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEE 480
L++ +EEQ E K E+ + +EV+ + TK + D ++ +++ E
Sbjct: 1344 LREQYEEEQ-------EAKAELQRGMSKANSEVAQWR---TKYETDAIQRTEELE---EA 1390
Query: 481 KLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKE 540
K +++ E + A+ S+ A+L++ + G+VE L + L K+
Sbjct: 1391 KKKLAQRLQDAEESIEAVNSKCASLEKT----KQRLQGEVEDLMIDVERANSLAANLDKK 1446
Query: 541 LVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKK 600
+K++A E K+ E++ LE A+K E + ++ ++K
Sbjct: 1447 QRNFDKVLA---------EWKQKYEESQAELEGAQK---------EARSLSTELFKMKNS 1488
Query: 601 CEKVAVGRNALRQAVKILEKGIENL-ESENKKLKKENEVSALKSEISALQQKCGAGAREG 659
E+ L++ K L++ I +L E + K +E+ K + + + + E
Sbjct: 1489 YEEALDHLETLKRENKNLQQEISDLTEQLGETGKSIHELEKAKKTVESEKSEIQTALEEA 1548
Query: 660 NGDVEVLKAGISDTKKEVNRLKKE--------HVEEERIVADSERKTAVDERKNAAAEAR 711
G +E ++ I + E+N++K E E E+I +S+R +D ++
Sbjct: 1549 EGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEMEQIKRNSQR--VIDSMQSTLDSEV 1606
Query: 712 KLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLL 771
+ ++ ++E + ++E++ H +Q E + +L + K+A + E +
Sbjct: 1607 RSRNDALRVKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQGQLKDAQLHLD-EAVRGQ 1665
Query: 772 VEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLL 816
+ + +++ ++E+++ A +E Q E +K+AE +L+
Sbjct: 1666 EDMKEQVAMVERRNSLMQAEIEELRAALE--QTERGRKVAEQELV 1708
Score = 116 bits (291), Expect = 2e-25
Identities = 182/875 (20%), Positives = 388/875 (43%), Gaps = 109/875 (12%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKL-----KKDIQEEQAQRKVAIEG 73
E+ KK + + L +K+ ++ I +LE+E ++ KKD + Q K+ E
Sbjct: 1040 EQEKKLRMDLERAKRKLEGDLKLAQESIMDLENEKQQSDEKIKKKDFEISQLLSKIEDEQ 1099
Query: 74 KLEISNTFAALENEVSALISENKKLKQDILEEQA--------QGKICDQLKKC-EKVVEG 124
L A L+ ++ L + ++L+++I E+A + + +L++ E++ E
Sbjct: 1100 SLG-----AQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEA 1154
Query: 125 RNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEG-KLEKSNAFAALENEVSA 183
A +++ +KR E+E +K+++D++E Q + + E++++ A L ++
Sbjct: 1155 GGATAAQIEMNKKR----EAEFQKMRRDLEESTLQHEATAAALRKEQADSVAELGEQIDN 1210
Query: 184 LKSENKKLKKDILEEQAQ-------RKVAMEGKLEISNAFAALENEVSALKSENKKLKQD 236
L+ +KL+K+ E + + + + K + LE+++S +K+++ + +
Sbjct: 1211 LQRVKQKLEKEKSEYKMEIDDLTSNMEAVAKAKANLEKMCRTLEDQLSEIKTKSDENVRQ 1270
Query: 237 ILDEQAQ--------GKFCDRLKKK---CEKVVEGRNALRQAVKILEKGIENLESENKKL 285
+ D AQ G+F +L++K ++ G+ A Q ++ L++ IE L
Sbjct: 1271 LNDMNAQRARLQTENGEFSRQLEEKEALVSQLTRGKQAYTQQIEELKRHIEEEVKAKNAL 1330
Query: 286 KKDIQEEH-------AQRKVEIEGKLEISNAFAALENEVSA--LKSENKKLKKDILEEQA 336
+Q Q + E E K E+ + +EV+ K E +++ E+A
Sbjct: 1331 AHAVQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEA 1390
Query: 337 QRKVAM-----EGKLEISNA-FAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKC 390
++K+A E +E N+ A+LE L+ E + L D+ + D+ ++
Sbjct: 1391 KKKLAQRLQDAEESIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANSLAANLDKKQRNF 1450
Query: 391 EKVV-EGRNALRQAVKILE---KGIENLESENKKLKKDIQEE----QAQRKIEIEGKLEI 442
+KV+ E + ++ LE K +L +E K+K +E + ++ + EI
Sbjct: 1451 DKVLAEWKQKYEESQAELEGAQKEARSLSTELFKMKNSYEEALDHLETLKRENKNLQQEI 1510
Query: 443 SNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEK---LEISNA-FAALENEVSAL 498
S+ L E E K KK + E+++I+ A+EE LE + ++ E++ +
Sbjct: 1511 SDLTEQL-GETGKSIHELEKAKKTVESEKSEIQTALEEAEGTLEHEESKILRVQLELNQV 1569
Query: 499 KSEI-AALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVAD-SERKTA 556
KSEI L +K + V+ + S + EV + L K+K+ D +E +
Sbjct: 1570 KSEIDRKLAEKDEEMEQIKRNSQRVIDSMQSTLDSEVRSRNDALRVKKKMEGDLNEMEIQ 1629
Query: 557 VDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVK 616
+ + AAEA+K L N + + + ++ G+ +++ V
Sbjct: 1630 LSHANRQAAEAQKQLR----------------NVQGQLKDAQLHLDEAVRGQEDMKEQVA 1673
Query: 617 ILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKE 676
++E+ +++E ++L+ E + +++ + A E G + + +TKK+
Sbjct: 1674 MVERRNSLMQAEIEELRAALEQTERGRKVAEQEL---VDASERVGLLHSQNTSLINTKKK 1730
Query: 677 VNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQ---IAKVEL 733
+ E + + E AV E +NA +A+K + +A E++K+ A +E
Sbjct: 1731 L--------EADLVQVQGEVDDAVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1782
Query: 734 RQVHLEKQVNERKMKL----AFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSE 789
+ +LE V + + +L + + K+ ++ E+ ++L E + AE + +
Sbjct: 1783 MKKNLEVTVKDLQHRLDEAESLAMKGGKKQLQKLESRVRELEAE-VEAEQRRGADAVKGV 1841
Query: 790 SELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQL 824
+ +++ ++ Q E++K + +L L D LQL
Sbjct: 1842 RKYERRVKELTYQTEEDKKNVI--RLQDLVDKLQL 1874
Score = 100 bits (250), Expect = 1e-20
Identities = 119/484 (24%), Positives = 231/484 (47%), Gaps = 47/484 (9%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++A+K +K+K+D+ + A+ K +L++K +++ +N L+ V
Sbjct: 844 AETEKEMAAMKENYEKMKEDLTKALAKKK---ELEEKMVSLLQEKNDLQLQV-------- 892
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSA--------LKSESTKLK 464
ESEN ++ E + KI++E KL+ +N E E++A L+ E ++LK
Sbjct: 893 TAESENLSDAEERCEGLIKSKIQLEAKLKETNERLEDEEEINAELTAKKRKLEDECSELK 952
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLK 524
KDI + + + +EK A EN+V L E+A+ + ++E E +
Sbjct: 953 KDIDDLELTLAKVEKEK-------HATENKVKNLTEEMASQDESIAKLTKEKKALQEAHQ 1005
Query: 525 AGISDTEKE---VNTLKKELVEKEKIVADSERKTAVDERKKAAAE-ARKLLEAAKKIAPE 580
+ D + E VNTL K + E+ V D E +++ + E A++ LE K+A E
Sbjct: 1006 QTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1065
Query: 581 KAVIPEPANCCSKCDE-LKKKCEKVAVGRNALRQAVKI---LEKGIENLESENKKLKKEN 636
I + N + DE +KKK +++ + + + L+K I+ L++ ++L E
Sbjct: 1066 S--IMDLENEKQQSDEKIKKKDFEISQLLSKIEDEQSLGAQLQKKIKELQARIEEL--EE 1121
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER 696
E+ A ++ + ++++ +RE E L+ T ++ KK E +++ D E
Sbjct: 1122 EIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKMRRDLEE 1181
Query: 697 KTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKT 756
T E A A L + AE+ +QI ++ + LEK+ +E KM++ +L+
Sbjct: 1182 STLQHE-----ATAAALRKEQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEID-DLTSN 1235
Query: 757 KEATKRFEAEKKKLLVEKINAESKIKKAQE---RSESELDKKTADMEKQQAEEQKKLAED 813
EA + +A +K+ + S+IK + R ++++ + A ++ + E ++L E
Sbjct: 1236 MEAVAKAKANLEKMCRTLEDQLSEIKTKSDENVRQLNDMNAQRARLQTENGEFSRQLEEK 1295
Query: 814 KLLL 817
+ L+
Sbjct: 1296 EALV 1299
Score = 67.4 bits (163), Expect = 1e-10
Identities = 79/410 (19%), Positives = 189/410 (45%), Gaps = 55/410 (13%)
Query: 20 ELKKKCEQVVVGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEQAQRKVAIE 72
EL+K + V ++ ++ A++ E +E+ ES E ++K +I + A++ +E
Sbjct: 1526 ELEKAKKTVESEKSEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEME 1585
Query: 73 -----GKLEISNTFAALENEVSA---LISENKKLKQDILEEQ------------------ 106
+ I + + L++EV + + KK++ D+ E +
Sbjct: 1586 QIKRNSQRVIDSMQSTLDSEVRSRNDALRVKKKMEGDLNEMEIQLSHANRQAAEAQKQLR 1645
Query: 107 -AQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIE 165
QG++ D ++ V G+ +++ V ++E+R +++E ++L+ +++ + RK+ +
Sbjct: 1646 NVQGQLKDAQLHLDEAVRGQEDMKEQVAMVERRNSLMQAEIEELRAALEQTERGRKVAEQ 1705
Query: 166 GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSA 225
++ S L ++ ++L + KKL+ D+++ Q + A++ E NA E +
Sbjct: 1706 ELVDASERVGLLHSQNTSLINTKKKLEADLVQVQGEVDDAVQ---EARNA----EEKAKK 1758
Query: 226 LKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-RNALRQAVKILEKG----IENLES 280
++ + +++ EQ +R+KK E V+ ++ L +A + KG ++ LES
Sbjct: 1759 AITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAESLAMKGGKKQLQKLES 1818
Query: 281 ENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILE-EQAQRK 339
++L+ +++ E + ++G E V L + ++ KK+++ + K
Sbjct: 1819 RVRELEAEVEAEQRRGADAVKG-------VRKYERRVKELTYQTEEDKKNVIRLQDLVDK 1871
Query: 340 VAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKK 389
+ ++ K+ A A E + + S +K++ ++ E Q + + K
Sbjct: 1872 LQLKVKVYKRQAEEA-EEQTNTHLSRYRKVQHELEEAQERADVAESQVNK 1920
Score = 61.2 bits (147), Expect = 1e-08
Identities = 69/323 (21%), Positives = 149/323 (45%), Gaps = 34/323 (10%)
Query: 13 NCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIE 72
N + ++ + ++ V G+ +++ V ++E+ +++E ++L+ +++ + RKVA +
Sbjct: 1646 NVQGQLKDAQLHLDEAVRGQEDMKEQVAMVERRNSLMQAEIEELRAALEQTERGRKVAEQ 1705
Query: 73 GKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAV 132
++ S L ++ ++LI+ KKL+ D++ Q QG++ D V E RNA +A
Sbjct: 1706 ELVDASERVGLLHSQNTSLINTKKKLEADLV--QVQGEVDD------AVQEARNAEEKAK 1757
Query: 133 KILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLK 192
K + E K+ E+ ++ +E+ K E E A+K K+L+
Sbjct: 1758 KAITDAAMMAEELKKEQDTSAHLERMKKNLEV---TVKDLQHRLDEAESLAMKGGKKQLQ 1814
Query: 193 KDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKK 252
K LE + + +E ++E A + V ++ +++K+ + K RL+
Sbjct: 1815 K--LESRVRE---LEAEVEAEQRRGA--DAVKGVRKYERRVKELTYQTEEDKKNVIRLQD 1867
Query: 253 KCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA- 311
+K L+ VK+ ++ E E + H R +++ +LE + A
Sbjct: 1868 LVDK-------LQLKVKVYKRQAEEAEEQT--------NTHLSRYRKVQHELEEAQERAD 1912
Query: 312 ALENEVSALKSENKKLKKDILEE 334
E++V+ L+++++ K EE
Sbjct: 1913 VAESQVNKLRAKSRDAGKSKDEE 1935
>MYHA_RAT (Q9JLT0) Myosin heavy chain, nonmuscle type B (Cellular
myosin heavy chain, type B) (Nonmuscle myosin heavy
chain-B) (NMMHC-B)
Length = 1976
Score = 139 bits (351), Expect = 2e-32
Identities = 196/884 (22%), Positives = 391/884 (44%), Gaps = 137/884 (15%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR------KVAIE 72
EE+ E V G Q IL+ + +++ + L++ + EE+ R KV E
Sbjct: 921 EEILHDLESRVEGEEERNQ---ILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 73 GKL-EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQA 131
K+ ++ LE++ S I E KKL +D + E ++ ++ +K + + + RN
Sbjct: 978 AKIKKMEEEVLLLEDQNSKFIKE-KKLMEDRIAE-CSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 132 VKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKL 191
+ LE+R++ E ++L E+A+RK++ E + + A L+ +V LK + K
Sbjct: 1036 ISDLEERLKKEEKTRQEL------EKAKRKLDGE-TTDLQDQIAELQAQVDELKVQLTKK 1088
Query: 192 KKDI-----------LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE 240
++++ L + KVA E + +I+ E+E A +++ +K K+D+ +E
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESE-KASRNKAEKQKRDLSEE 1147
Query: 241 QAQGKFCDRLKKKCEKVV-------EGRNALRQAVKILEKGIENLESENKKLKKDIQEEH 293
+ LK + E + E R Q V L+K +E+ ++ +D+++ H
Sbjct: 1148 ------LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRH 1201
Query: 294 AQRKVEIEGKLEISNAFAA-LENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAF 352
A E+ +LE + F A LE L+++NK+L ++ KV + K E
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV-------KVLQQVKAE----- 1249
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
SE+K+ K D ++ K + + + E + E N L+ + + +E
Sbjct: 1250 -----------SEHKRKKLDAQVQELHAKVSEGDRLRVE-LAEKANKLQNELDNVSTLLE 1297
Query: 413 NLESENKKLKKD-------IQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTK--- 462
E + K KD +Q+ Q + E KL +S+ LE E ++L+ + +
Sbjct: 1298 EAEKKGMKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 463 ----LKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQ----------K 508
L+K +L Q+Q+ ++ + LE L ++ AL Q K
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDK 1417
Query: 509 CGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERKKAAAE 566
+++ L + + V+ L+K+ + ++++A+ + +A +ER +A AE
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAE 1477
Query: 567 AR----------KLLEAAKKIAPE-----KAVIPEPANCCSKCDELKKKCEKVAVGRNAL 611
AR + LE A + E K + + + S D++ K ++ + AL
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537
Query: 612 RQAVKILEKGIENLE-----SENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVL 666
Q V+ + +E LE +E+ KL+ E + A+K++ Q E N + + L
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT----RDEQNEEKKRL 1593
Query: 667 KAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL---LEAPKKIAAE 723
K+V L+ E +E+ER +R AV +K + + L +EA K E
Sbjct: 1594 ------LLKQVRELEAE-LEDER----KQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 724 VEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL--LVEKINAESKI 781
V KQ+ K++ + ++++ E + +++KE+ K+ ++ + ++ L E++ + +
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 782 KKAQERSESELDKKTADME--KQQAEEQKKLAEDKLLLLGDSLQ 823
++ E+ EL + A+ K ++K+ E ++ L + L+
Sbjct: 1703 RRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELE 1746
Score = 130 bits (327), Expect = 1e-29
Identities = 200/881 (22%), Positives = 387/881 (43%), Gaps = 132/881 (14%)
Query: 12 ANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQE-EQAQRKVA 70
A C S+ E ++K + + RN +Q V I +LE KK +K QE E+A+RK+
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRN--KQEVMI-----SDLEERLKKEEKTRQELEKAKRKLD 1061
Query: 71 IEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQ 130
E ++ + A L+ +V L K++ EE+ QG + + ++ + NAL+
Sbjct: 1062 GE-TTDLQDQIAELQAQVDEL-----KVQLTKKEEELQGALA---RGDDETLHKNNALKV 1112
Query: 131 AVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKK 190
A L+++ +L++D + E+A R K EK L E+ ALK+E
Sbjct: 1113 A--------RELQAQIAELQEDFESEKASRN-----KAEKQKR--DLSEELEALKTE--- 1154
Query: 191 LKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ------DILDEQAQG 244
L+ + AQ+++ + + E++ ALE+E +++ + ++Q + L EQ +
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 245 --KFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEG 302
+F L+K + + L VK+L++ E + KKL +QE HA+
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 303 KLEISNAFAALENE---VSAL--KSENKKLK---------------KDILEEQAQRKVAM 342
++E++ L+NE VS L ++E K +K +++L+E+ ++K+ +
Sbjct: 1275 RVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQEETRQKLNL 1334
Query: 343 EGKL---------------EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLK 387
++ E A LE +V AL+S+ K+ + ++ + ++ K
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAK 1394
Query: 388 KKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQ------EEQAQRKIEIEGKLE 441
KK K VE AL Q ++ + LE +L++++ + Q Q +E K +
Sbjct: 1395 KKLLKDVE---ALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQK 1451
Query: 442 ISNAFAALENEVSALKSESTKLKKDILEEQAQIKV--------AIEEKLEISNAFAALEN 493
+ A E +SA +E ++D E +A+ K A+EE LE F
Sbjct: 1452 KFDQLLAEEKGISARYAE----ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 494 EVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSER 553
++ A ++ + + G E +E K + +E+ T +EL ++ + D++
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHE----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 554 KTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQ 613
+ V+ + A R L ++ +K ++ + EL+ + E R
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLL------LKQVRELEAELEDERKQRALAVA 1617
Query: 614 AVKILEKGIENLESENKKLKK-ENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISD 672
+ K +E +++LE++ + K +EV ++ A + E + + A +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 673 TKKEVNRLKKEHV---------EEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAA- 722
++K++ L+ E + E R A+ ER DE N+A+ LL+ +++ A
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEAR 1737
Query: 723 ------EVEKQIAKVELRQVHLEK---QVNERKMKLAFELS---KTKEATKRFEAEKKKL 770
E+E++ + +EL K QV+ +LA E S K+ A ++ E + K+L
Sbjct: 1738 IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKEL 1797
Query: 771 LVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLA 811
+ E +K + + S L+ K +E+Q +E K+ A
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Score = 112 bits (279), Expect = 5e-24
Identities = 137/652 (21%), Positives = 289/652 (44%), Gaps = 68/652 (10%)
Query: 44 KGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISEN-------K 96
K LES+ + ++ +QEE Q KL +S+ LE E ++L + K
Sbjct: 1308 KDAAGLESQLQDTQELLQEETRQ-------KLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 97 KLKQDILEEQAQ-----GKICDQLKKCEKVVEGRNALRQAVKILEKRIEN-------LES 144
L++ +L Q+Q K+ D L E + E + L + V+ L +R+E LE
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEK 1420
Query: 145 ENKKLKKDIQE------EQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEE 198
+L++++ + Q Q +E K +K + A E +SA +E ++D E
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAE----ERDRAEA 1476
Query: 199 QAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVV 258
+A+ K L ++ A + +NK+L+ D+ D + D + K ++
Sbjct: 1477 EAREKETKA--LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK---DDVGKNVHELE 1531
Query: 259 EGRNALRQAVKILEKGIENLESENK-------KLKKDIQEEHAQRKVEIEGKLEISNAFA 311
+ + AL Q V+ + +E LE E + +L+ ++Q AQ + +++ + E +
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN---- 1587
Query: 312 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 371
E + L + ++L+ ++ +E+ QR +A+ K ++ LE ++ A ++ +
Sbjct: 1588 --EEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 372 DILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 431
+ + QAQ K +++ E+ R+ + K EK +++LE+E +L++++ +
Sbjct: 1646 QLRKLQAQMK---DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 432 RKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAAL 491
R+ + + E+++ A + SAL E +L+ I + + +++ +++ F
Sbjct: 1703 RRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 492 ENEVSALKSEIAA---LQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIV 548
+V L +E+AA QK ++ + LKA + + E V + K + +
Sbjct: 1763 TLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 549 ADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGR 608
+ E K+ AA + + KK+ K + + + D+ K++ EK
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKL---KEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 609 NALRQAVKILEKGIENLESENKKLKKENEVS-----ALKSEISALQQKCGAG 655
L++ ++ E+ + +KL++E + + L E+S L+ + G
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Score = 65.9 bits (159), Expect = 4e-10
Identities = 66/332 (19%), Positives = 152/332 (44%), Gaps = 56/332 (16%)
Query: 7 VIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 66
VI + ++ ++ +++ E+ R+ + K EK +++LE+E +L++++ +
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 67 RKVAIEGKLEISNTFAALENEVSALISENKK-------LKQDILEEQAQGKIC-DQLKKC 118
R+ A + + E+++ A + SAL+ E ++ L++++ EEQ+ ++ D+ +K
Sbjct: 1703 RRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 119 EKVVEGRN----ALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAF 174
V+ N A R A + + + LE +NK+LK +QE + K + + +
Sbjct: 1763 TLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI------ 1816
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
+ALE ++ L+ + LE++A+ + A ++ KKLK
Sbjct: 1817 SALEAKIGQLEEQ--------LEQEAKERAAAN----------------KLVRRTEKKLK 1852
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHA 294
+ + + + + D+ K++ EK L++ ++ E+ + +KL++++
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD---- 1908
Query: 295 QRKVEIEGKLEISNAFAALENEVSALKSENKK 326
+ + A L EVS LK+ ++
Sbjct: 1909 ----------DATEANEGLSREVSTLKNRLRR 1930
Score = 56.6 bits (135), Expect = 3e-07
Identities = 101/485 (20%), Positives = 209/485 (42%), Gaps = 80/485 (16%)
Query: 354 ALENEVSALKSENKKLKQDIL--EEQAQGKFCDQL---KKKCEKVVEGRNALRQAVKILE 408
+L ++ L++ N + I+ E+ GK L + +C V+EG ++I
Sbjct: 660 SLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEG-------IRICR 712
Query: 409 KGIEN-LESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL--KK 465
+G N + + + + +I A K ++GK ALE + + + +K+ +
Sbjct: 713 QGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRA 772
Query: 466 DIL---EEQAQIKV--------AIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSR 514
+L EE+ +K+ A+ AFA + ++SALK LQ+ C A +
Sbjct: 773 GVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK----VLQRNCAAYLK 828
Query: 515 EGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK-KAAAEARKLLEA 573
+ + +V L + ++E++ A E V E++ K E ++
Sbjct: 829 LRHWQWWRVFT-------KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK 881
Query: 574 AKKIAPEKAVIPEPANCCSKC-DELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL 632
+++ EK ++ E ++ E ++ ++A + L + + LE +E E N+ L
Sbjct: 882 HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEGEEERNQIL 941
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
+NE +++ I L+++ E G + L+ +K K + +EEE ++
Sbjct: 942 --QNEKKKMQAHIQDLEEQLD----EEEGARQKLQL-----EKVTAEAKIKKMEEEVLLL 990
Query: 693 DSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFE 752
+ + + E+K L+E AE Q+A+ E + +L K N++++ ++
Sbjct: 991 EDQNSKFIKEKK--------LMEDR---IAECSSQLAEEEEKAKNLAKIRNKQEVMISD- 1038
Query: 753 LSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAE 812
L E++ E K ++ E+++ +LD +T D++ Q AE Q ++ E
Sbjct: 1039 ------------------LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDE 1080
Query: 813 DKLLL 817
K+ L
Sbjct: 1081 LKVQL 1085
Score = 52.0 bits (123), Expect = 6e-06
Identities = 50/165 (30%), Positives = 82/165 (49%), Gaps = 15/165 (9%)
Query: 662 DVEVLKAGISDTK-----KEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEA 716
D E+LK TK +E+ R ++ +EE+ I+A E+ A E A E R L A
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA--EQLQAETELFAEAEEMRARLAA 915
Query: 717 PKKIAAEVEKQI-AKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKI 775
K+ E+ + ++VE + + NE+K K+ + +E E ++KL +EK+
Sbjct: 916 KKQELEEILHDLESRVEGEEERNQILQNEKK-KMQAHIQDLEEQLDEEEGARQKLQLEKV 974
Query: 776 NAESKIKKAQER------SESELDKKTADMEKQQAEEQKKLAEDK 814
AE+KIKK +E S+ K+ ME + AE +LAE++
Sbjct: 975 TAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
>MYH2_HUMAN (Q9UKX2) Myosin heavy chain, skeletal muscle, adult 2
(Myosin heavy chain IIa) (MyHC-IIa)
Length = 1941
Score = 138 bits (348), Expect = 5e-32
Identities = 177/805 (21%), Positives = 362/805 (43%), Gaps = 113/805 (14%)
Query: 43 EKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDI 102
EK + ++ E +K+K ++ + +A+RK LE ++ L+ E L+ +
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRK--------------ELEEKMVTLLKEKNDLQLQV 897
Query: 103 LEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKL---KKDIQEEQAQ 159
+ +A+G + D ++C+++++ + L +K + +R E+ E N +L K+ +++E ++
Sbjct: 898 -QAEAEG-LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 160 RKIEIE------GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 213
K +I+ K+EK A EN+V L E L + I + ++K E +
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1013
Query: 214 NAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEK 273
+ A E++V+ L KL+Q + D + + +L+ E+ + L +K+ ++
Sbjct: 1014 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER---AKRKLEGDLKLAQE 1070
Query: 274 GIENLESENKKL-----KKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLK 328
I ++E+E ++L KK+ + + Q K+E E L I L+ ++ L++ ++L+
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ-----LQKKIKELQARIEELE 1125
Query: 329 KDILEEQAQRKVAMEGKLEISNAFAALENEVSAL--------------KSENKKLKQDIL 374
++I E+A R A + + ++S + + ++E +K+++D+
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 375 EE--QAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR 432
E Q + KK + V E L + + L++ + LE E ++K +I + +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1241
Query: 433 KIEIEGKLEISNAFAALENEVSALKS---ESTKLKKDILEEQAQIKVAIEEKLEISNAFA 489
+ + K + LE+++S LKS E +L D+ ++ +++ S F+
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE-------SGEFS 1294
Query: 490 ALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVA 549
+E AL S+++ G + +E LK + + K N L L + +
Sbjct: 1295 RQLDEKEALVSQLS-------RGKQAFTQQIEELKRQLEEEIKAKNALAHAL-QSSRHDC 1346
Query: 550 DSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRN 609
D R+ +E++ A R L +A ++A + A + +EL++ +K+A
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA--IQRTEELEEAKKKLAQRLQ 1404
Query: 610 ALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGA-GAREGNGD------ 662
A + V+ + +LE ++L +NEV L ++ C A ++ N D
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRL--QNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462
Query: 663 ---VEVLKAGISDTKKEVNRLKKEHVEEERIVADS--ERKTAVDERKNAAAEARKLLEAP 717
E A + ++KE L E + + +S + +T E KN E L E
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ- 1521
Query: 718 KKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINA 777
AE K+I ++E ++KQV + K +L L +EA E E+ K+L
Sbjct: 1522 ---IAEGGKRIHELE----KIKKQVEQEKCELQAAL---EEAEASLEHEEGKIL------ 1565
Query: 778 ESKIKKAQERSESELDKKTADMEKQ 802
+I+ + +SE+D+K A+ +++
Sbjct: 1566 --RIQLELNQVKSEVDRKIAEKDEE 1588
Score = 137 bits (346), Expect = 9e-32
Identities = 172/842 (20%), Positives = 380/842 (44%), Gaps = 106/842 (12%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E L + I + ++K E +
Sbjct: 952 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 77 ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ A E++V+ L KL+Q + + +G + + K + + L +K+ +
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQV--DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 137 KRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAA-LENEVSALKSENKKLKKDI 195
+ I ++E+E ++L + +++++ + ++ K+E A L+ ++ L++ ++L+++I
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEIS-NLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 196 LEEQAQRKVAMEGKLEISNAFAALENEVSAL--------------KSENKKLKQDILDE- 240
E+A R A + + ++S + + ++E +K+++D+ +
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 241 -QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVE 299
Q + KK + V E L + + L++ + LE E ++K +I + + +
Sbjct: 1189 LQHEATAATLRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 300 IEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEI-SNAFAALENE 358
+ K + LE+++S LKS+ ++ ++ I + AQR G+L+ S F+ +E
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR-----GRLQTESGEFSRQLDE 1299
Query: 359 VSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESEN 418
AL S+ + KQ ++ ++LK++ E+ ++ +NAL A +++ +
Sbjct: 1300 KEALVSQLSRGKQAFTQQ------IEELKRQLEEEIKAKNALAHA-------LQSSRHDC 1346
Query: 419 KKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAI 478
L++ +EEQ E K E+ A + EV+ + TK + D ++ +++
Sbjct: 1347 DLLREQYEEEQ-------ESKAELQRALSKANTEVAQWR---TKYETDAIQRTEELE--- 1393
Query: 479 EEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLK 538
E K +++ A E V A+ ++ A+L++ + +VE L + T L
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKT----KQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 539 KELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELK 598
K+ +KI+A E K+ E LEA++K E + ++ ++K
Sbjct: 1450 KKQRNFDKILA---------EWKQKCEETHAELEASQK---------EARSLGTELFKIK 1491
Query: 599 KKCEKVAVGRNALRQAVKILEKGIENL-ESENKKLKKENEVSALKSEISALQQKC--GAG 655
E+ L++ K L++ I +L E + K+ +E+ +K ++ Q+KC A
Sbjct: 1492 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE--QEKCELQAA 1549
Query: 656 AREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLE 715
E +E + I + E+N++K E +R +A+ + + +D+ K R +
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKS---EVDRKIAEKDEE--IDQLKR--NHIRIVES 1602
Query: 716 APKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKI 775
+ AE+ + + L++ +E +NE +++L EA + + + L +I
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKK-KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 776 NAESKIKKAQERSE-------------SELDKKTADMEKQQAEEQKKLAEDKLLLLGDSL 822
+ + ++ ++ E +E+++ A +E Q E +K+AE +LL + +
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE--QTERSRKIAEQELLDASERV 1719
Query: 823 QL 824
QL
Sbjct: 1720 QL 1721
Score = 125 bits (314), Expect = 5e-28
Identities = 147/661 (22%), Positives = 312/661 (46%), Gaps = 69/661 (10%)
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
A E E++ +K E +K+K ++ + +A+RK LE ++ L E L+
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRK--------------ELEEKMVTLLKEKNDLQ 894
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL---KKDIQE 291
L QA+ + +++C+++++ + L +K + + E+ E N +L K+ +++
Sbjct: 895 ---LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951
Query: 292 EHAQRKVEIEGKLEISNAFA-----ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKL 346
E ++ K +I+ LE++ A A EN+V L E L + I + ++K E
Sbjct: 952 ECSELKKDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 347 EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKI 406
+ + A E++V+ L KL+Q + + +G +Q KK + + L +K+
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQV--DDLEGSL-EQEKKLRMDLERAKRKLEGDLKL 1067
Query: 407 LEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKD 466
++ I ++E+E ++L + +++++ EISN + +E+E ++ +L+K
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKE----------FEISNLQSKIEDE----QALGIQLQKK 1113
Query: 467 ILEEQAQIKVAIEEKLEISNAF-AALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKA 525
I E QA+I+ +EE++E A A E + S L E+ + ++ + +E+ K
Sbjct: 1114 IKELQARIE-ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172
Query: 526 GISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIP 585
++ +K L++ ++ E A +K A D + + L +K+ EK+ +
Sbjct: 1173 REAEFQKMRRDLEEATLQHEATAATLRKKHA-DSVAELGEQIDNLQRVKQKLEKEKSEMK 1231
Query: 586 EPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEI 645
+ D+L E V+ + L + + LE + L+S K+ +++ ++ L ++
Sbjct: 1232 ------MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS--KEEEQQRLINDLTAQR 1283
Query: 646 SALQQKCGAGAR---EGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDE 702
LQ + G +R E V L G +++ LK++ EE I A + A+
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ--LEEEIKAKNALAHALQS 1341
Query: 703 RKNAAAEARKLLEAPKKIAAEVEKQIAK--VELRQVHLEKQVNERKMKLAFELSKTKEAT 760
++ R+ E ++ AE+++ ++K E+ Q + + + + E +K K A
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 761 KRFEAEKKKLLVEKINAE-SKIKKAQERSESELDKKTADMEKQQAE----EQKKLAEDKL 815
+ AE+ VE +NA+ + ++K ++R ++E++ D+E+ A ++K+ DK+
Sbjct: 1402 RLQAAEEH---VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458
Query: 816 L 816
L
Sbjct: 1459 L 1459
Score = 112 bits (279), Expect = 5e-24
Identities = 188/854 (22%), Positives = 385/854 (45%), Gaps = 108/854 (12%)
Query: 19 EELKKKCEQVVVGRNALR--QAVKI-LEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
E+LKKK ++ ++ + QA+ I L+K I+ L++ ++L+++I+ E+A R A + +
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1143
Query: 76 EISNTFAALENEV-------SALISENKK-------LKQDILEEQAQGKICDQLKKCEKV 121
++S + + SA I NKK +++D+ E Q + + +K
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR-KKH 1202
Query: 122 VEGRNALRQAVKILEKRIENLESENKKLKKDIQE--EQAQRKIEIEGKLEKSNAFAALEN 179
+ L + + L++ + LE E ++K +I + + + +G LEK LE+
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM--CRTLED 1260
Query: 180 EVSALKSENKKLKKDILEEQAQRKVAMEGKLEI-SNAFAALENEVSALKSENKKLKQDIL 238
++S LKS+ ++ ++ I + AQR G+L+ S F+ +E AL S+ + KQ
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQR-----GRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 239 DEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKV 298
+ + LK++ E+ ++ +NAL A++ + L + EE + K
Sbjct: 1316 QQ------IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ--------YEEEQESKA 1361
Query: 299 EIEGKLEISNAFAA-----LENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNA-F 352
E++ L +N A E + E ++ KK + AQR A E +E NA
Sbjct: 1362 ELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL----AQRLQAAEEHVEAVNAKC 1417
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVV-EGRNALRQAVKILE--- 408
A+LE L++E + L D+ A D+ ++ +K++ E + + LE
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 409 KGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKS---ESTKLKK 465
K +L +E K+K +E Q + + + L +++ E K+KK
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 466 DILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKA 525
+ +E+ +++ A+EE A A+LE+E + +I +Q + E +
Sbjct: 1538 QVEQEKCELQAALEE------AEASLEHE----EGKILRIQLELNQVKSE-------VDR 1580
Query: 526 GISDTEKEVNTLKKE---LVEKEKIVADSE---RKTAVDERKKAAAEARKL---LEAAKK 576
I++ ++E++ LK+ +VE + D+E R A+ +KK + ++ L A +
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640
Query: 577 IAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKEN 636
+A E + N + + + + L++ + ++E+ L++E ++L+
Sbjct: 1641 MAAE--ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1698
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER 696
E + +I A Q+ A R V++L + +N KK +E + E
Sbjct: 1699 EQTERSRKI-AEQELLDASER-----VQLLH---TQNTSLINTKKK--LETDISQMQGEM 1747
Query: 697 KTAVDERKNAAAEARKLLEAPKKIAAEVEKQ---IAKVELRQVHLEKQVNERKMKL---- 749
+ + E +NA +A+K + +A E++K+ A +E + ++E+ V + +++L
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1807
Query: 750 AFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKK 809
L K+ ++ EA ++L E + +E K + + +++ ++ Q E++K
Sbjct: 1808 QLALKGGKKQIQKLEARVRELEGE-VESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 810 LAEDKLLLLGDSLQ 823
+ +L L D LQ
Sbjct: 1867 IL--RLQDLVDKLQ 1878
Score = 92.8 bits (229), Expect = 3e-18
Identities = 167/739 (22%), Positives = 314/739 (41%), Gaps = 108/739 (14%)
Query: 20 ELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKV----AIEGKL 75
E+K + + + + +A LEK LE + +LK +EE+ QR + A G+L
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS--KEEEQQRLINDLTAQRGRL 1286
Query: 76 EI-SNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKI 134
+ S F+ +E AL+S+ + KQ ++ + K ++ E+ ++ +NAL A
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK-----RQLEEEIKAKNALAHA--- 1338
Query: 135 LEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAA-----LENEVSALKSENK 189
+++ + L++ +EEQ + K E++ L K+N A E + E +
Sbjct: 1339 ----LQSSRHDCDLLREQYEEEQ-ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393
Query: 190 KLKKDILEEQAQRKVAMEGKLEISNA-FAALENEVSALKSENKKLKQDI---------LD 239
+ KK + AQR A E +E NA A+LE L++E + L D+ LD
Sbjct: 1394 EAKKKL----AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 240 EQAQG--KFCDRLKKKCEKV--------VEGRNALRQAVKI---LEKGIENLES---ENK 283
++ + K K+KCE+ E R+ + KI E+ ++ LE+ ENK
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENK 1509
Query: 284 KLKKDIQEE-----------HAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDIL 332
L+++I + H K++ + + E AALE ++L+ E K+ + L
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 333 EEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL---KQDILEEQAQGKF-CDQLKK 388
E + K E+ A + E+ LK + ++ Q L+ + + + +LKK
Sbjct: 1570 ELN-------QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 389 KCE-KVVEGRNALRQAVKILEKGIENLESENKKLKK-DIQEEQAQRKIEIEGKLEISNAF 446
K E + E L A ++ + + N + LK I + A R E ++
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE-----DLKEQL 1677
Query: 447 AALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALE-------NEVSALK 499
A +E + L++E +L+ + + + K+A +E L+ S L N L+
Sbjct: 1678 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 500 SEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKE---LVEKEKIVADSERKTA 556
++I+ +Q + +E E K I+D LKKE E++ + E+
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 557 VDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVK 616
+ + AE L K+I +A + E E++ + ++ A LR+
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEARVRELEG------EVESEQKRNAEAVKGLRKH-- 1849
Query: 617 ILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKE 676
E+ ++ L + ++ +K + L+ + LQ K + R+ E ++ +K
Sbjct: 1850 --ERRVKELTYQTEEDRK--NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Query: 677 VNRLKKEHVEEERIVADSE 695
+ L E EE +A+S+
Sbjct: 1906 QHEL--EEAEERADIAESQ 1922
Score = 90.1 bits (222), Expect = 2e-17
Identities = 125/547 (22%), Positives = 243/547 (43%), Gaps = 52/547 (9%)
Query: 2 ASEKAVIPEPANCCS---KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKK 58
A+E+ V A C S + L+ + E +++ A L+K N + + K+
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464
Query: 59 DIQE-----EQAQRKVAIEGK--LEISNTFAALENEVSALISENKKLKQDILEEQAQ--- 108
+E E +Q++ G +I N + +++ L ENK L+Q+I + Q
Sbjct: 1465 KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524
Query: 109 -GKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGK 167
GK +L+K +K VE QA LE+ +LE E K+ + IQ E Q K E++ K
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAA--LEEAEASLEHEEGKILR-IQLELNQVKSEVDRK 1581
Query: 168 L-EKSNAFAALE-NEVSALKSENKKLKKDI--LEEQAQRKVAMEGKLEISNAFAALENEV 223
+ EK L+ N + ++S L +I + + K MEG L N +
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641
Query: 224 SALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENK 283
+A N + Q IL + + + + + L++ + ++E+ L++E +
Sbjct: 1642 AAEALRNYRNTQGILKD---------TQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692
Query: 284 KLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAME 343
+L+ +++ RK+ + L+ S L + ++L + KKL+ DI + Q + + ++
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ 1752
Query: 344 GKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEG-----RN 398
E NA E + ++ + +++ +EQ +++KK E+ V+
Sbjct: 1753 ---EARNA----EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDE 1805
Query: 399 ALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKS 458
A + A+K +K I+ LE+ ++L+ +++ EQ + ++G + L + +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 459 ESTKLKKDILEEQAQIKV---AIEEKLEISNA----FAALENEVSAL--KSEIAALQ-QK 508
+L+ + + QA++K EE E SN F L++E+ +++IA Q K
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 509 CGAGSRE 515
SRE
Sbjct: 1926 LRVKSRE 1932
Score = 87.0 bits (214), Expect = 2e-16
Identities = 119/596 (19%), Positives = 251/596 (41%), Gaps = 115/596 (19%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
EELK++ E+ + +NAL A +++ + L++ +EEQ E K E+
Sbjct: 1319 EELKRQLEEEIKAKNALAHA-------LQSSRHDCDLLREQYEEEQ-------ESKAELQ 1364
Query: 79 NTFAALENEVSALIS--ENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ EV+ + E +++ E+A+ K+ +L+ E+ VE NA +++ +
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 137 KRIEN------------------LESENKKLKKDIQE-----EQAQRKIEIEGKLEKS-- 171
+R++N L+ + + K + E E+ ++E K +S
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 172 -------NAFAALENEVSALKSENKKLKKDILEEQAQ-----------RKVAMEGKLEIS 213
NA+ +++ LK ENK L+++I + Q K+ + + E
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 214 NAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEK 273
AALE ++L+ E K+ + L+ DR K EK E R ++I+E
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR--KIAEKDEEIDQLKRNHIRIVES 1602
Query: 274 GIENLESE----------NKKLKKDIQE-----EHAQR-------------------KVE 299
L++E KK++ D+ E HA R ++
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 300 IEGKL----EISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAAL 355
++ L ++ A +E + L++E ++L+ + + + RK+A + L+ S L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722
Query: 356 ENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILE--KGIEN 413
+ ++L + KKL+ DI Q QG+ D L++ + + A+ A + E K ++
Sbjct: 1723 HTQNTSLINTKKKLETDI--SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780
Query: 414 LESENKKLKKDIQEEQAQRKIEIE---------GKLEISNAFA---ALENEVSALKSEST 461
+ +++KK++++ ++ ++ GK +I A LE EV + + +
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNA 1840
Query: 462 KLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGN 517
+ K + + + ++K + E L++ V L++++ + +++ + N
Sbjct: 1841 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 65.5 bits (158), Expect = 6e-10
Identities = 87/422 (20%), Positives = 191/422 (44%), Gaps = 69/422 (16%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ--RKVAIEGK 74
+ EL+K +QV + L+ A++ E +E+ E + +++ ++ + +++ RK+A E
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA-EKD 1586
Query: 75 LEIS----NTFAALENEVSALISE----------NKKLKQDILEEQ-------------- 106
EI N +E+ S L +E KK++ D+ E +
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 107 -----AQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRK 161
QG + D + + + L++ + ++E+R L++E ++L+ +++ + RK
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 162 IEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 221
I + L+ S L + ++L + KKL+ DI + Q + + ++ E NA E
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ---EARNA----EE 1759
Query: 222 EVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-----RNALRQAVKILEKGIE 276
+ ++ + +++ EQ +R+KK E+ V+ A + A+K +K I+
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQ 1819
Query: 277 NLESENKKLKKDIQEE-------------HAQRKVEIEGKLEISNA-FAALENEVSALKS 322
LE+ ++L+ +++ E H +R E+ + E L++ V L++
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879
Query: 323 ENKKLKK--DILEEQAQRKVAMEGKL-----EISNAFAALENEVSALKSENKKLKQDILE 375
+ K K+ + EEQ+ +A KL E E++V+ L+ +++++ ++
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Query: 376 EQ 377
E+
Sbjct: 1940 EE 1941
>MYH8_HUMAN (P13535) Myosin heavy chain, skeletal muscle, perinatal
(MyHC-perinatal)
Length = 1937
Score = 138 bits (347), Expect = 7e-32
Identities = 208/916 (22%), Positives = 396/916 (42%), Gaps = 144/916 (15%)
Query: 22 KKKCEQVVVG-RNALRQAVKI---LEKGIENLESENKKLKK---DIQEEQAQRKVAIEGK 74
K K EQ V +L Q K+ LE+ LE + K ++ D++ ++ Q +E K
Sbjct: 1027 KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKK 1086
Query: 75 -LEISNTFAALENEVSALISENKKLKQ-----DILEEQAQGKICDQLKK----------- 117
EISN + +E+E + I KK+K+ + L E+ + + + K
Sbjct: 1087 EFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSREL 1146
Query: 118 ---CEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEK-SNA 173
E++ E A V++ +KR E+E +KL++D++E Q + + +K +++
Sbjct: 1147 EEISERLEEAGGATSAQVELNKKR----EAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 174 FAALENEVSALKSENKKLKK---------DILEEQAQRKVAMEGKLEISNAFAALENEVS 224
A L ++ L+ +KL+K D L A+ +G LE +LE++VS
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE--KMCRSLEDQVS 1260
Query: 225 ALKSENKKLKQDILDEQAQ--------GKFCDRLKKKCEKVVEGRNALRQAVKILEKGIE 276
LK++ ++ ++ I D AQ G++ +L +K V + + + + + +E+
Sbjct: 1261 ELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH 1320
Query: 277 NLESENK----------KLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSA--LKSEN 324
LE E K + D Q + E EGK E+ A + +EV+ K E
Sbjct: 1321 QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 325 KKLKKDILEEQAQRKVAM-----EGKLEISNA-FAALENEVSALKSENKKLKQDILEEQA 378
+++ E+A++K+A E +E NA A+LE L++E + L D+ A
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 379 QGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEG 438
D+ ++ +KV+ + +Q + + +E + E++ L ++ + + + ++
Sbjct: 1441 ACAALDKKQRNFDKVL---SEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ 1497
Query: 439 KLEISNAFAALENEVSALKS----------ESTKLKKDILEEQAQIKVAIEE-------- 480
+ L+ E+S L E K+KK + +E+ +I+ A+EE
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHE 1557
Query: 481 --------------KLEISNAFAALENEVSALKSE----IAALQQKCGAGSREGNGDVEV 522
K E+ A + E+ LK + +Q A R N + V
Sbjct: 1558 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRV 1617
Query: 523 LKAGISDTEKEVNTLKKELVEKEKIVADSER--KTAVDERKKAAAEARKLLEAAKKIAPE 580
K E ++N ++ +L ++ A+S R + K+ L + + +
Sbjct: 1618 KKK----MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ 1673
Query: 581 KAVIPEPANCC-SKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL-----KK 634
A++ AN ++ +EL E+ R Q + + ++ L ++N L K
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1733
Query: 635 ENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEH---VEEERIV 691
EN+VS L+SE+ + Q E E K I+D LKKE ER+
Sbjct: 1734 ENDVSQLQSEVEEVIQ-------ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786
Query: 692 ADSERKTAVDERKNAAAEARKL-LEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLA 750
+ E+ V + ++ EA +L L+ KK ++E ++ ++E + +K+ E L
Sbjct: 1787 KNLEQ--TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR 1844
Query: 751 FELSKTKEATKRFEAEKKKL-----LVEKINAESK-----IKKAQERSESELDK-KTADM 799
+ KE T + E ++K + LV+K+ A+ K ++A+E+S + L K +
Sbjct: 1845 KHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 800 EKQQAEEQKKLAEDKL 815
E ++AEE+ +AE ++
Sbjct: 1905 ELEEAEERADIAESQV 1920
Score = 132 bits (332), Expect = 4e-30
Identities = 193/884 (21%), Positives = 384/884 (42%), Gaps = 147/884 (16%)
Query: 20 ELKKKCEQVVVGRNALRQAVKILEKGIE--------------NLESENKKLKKDIQE--- 62
+ +++CEQ++ + L +K + + E LE E +LKKDI +
Sbjct: 903 DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 63 ---EQAQRKVAIEGKLE-ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKC 118
+ + K A E K++ ++ A L+ ++ L E K L+E Q + D +
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKK-----ALQETHQQTLDDLQAEE 1017
Query: 119 EKVVEGRNALRQAVKILEKRIENLE---SENKKLKKDIQEEQAQRKIEIEGKLEKSNAFA 175
+KV N L +A LE+++++LE + KKL+ D+ E+A+RK+E + KL +
Sbjct: 1018 DKV----NILTKAKTKLEQQVDDLEGSLEQEKKLRMDL--ERAKRKLEGDLKLAQE---- 1067
Query: 176 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 235
S + EN K + L+E+ ++K + EISN + +E+E + KK+K+
Sbjct: 1068 ------STMDMENDKQQ---LDEKLEKK-----EFEISNLISKIEDEQAVEIQLQKKIKE 1113
Query: 236 -----DILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKG---------IENLESE 281
+ L E+ + + R K + ++ R + ++ E G + E+E
Sbjct: 1114 LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE 1173
Query: 282 NKKLKKDIQE---EH-----AQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILE 333
+KL++D++E +H A RK + E+ L+ L+ E +LK + +
Sbjct: 1174 FQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD 1233
Query: 334 EQAQRKVAMEGKLEISNAFAALENEVSALKS---ENKKLKQDILEEQAQ-----GKFCDQ 385
+ + + K + +LE++VS LK+ E ++L D+ ++A+ G++ Q
Sbjct: 1234 LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ 1293
Query: 386 LKKKCEKVVEGRNALRQAVKILEKGIENLESENK----------KLKKDIQEEQAQRKIE 435
L +K V + + + + + +E+ LE E K + D + Q + E
Sbjct: 1294 LDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEE 1353
Query: 436 IEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEV 495
EGK E+ A + +EV+ + TK + D ++ +++ E K +++ E V
Sbjct: 1354 QEGKAELQRALSKANSEVAQWR---TKYETDAIQRTEELE---EAKKKLAQRLQEAEEHV 1407
Query: 496 SALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKT 555
A+ ++ A+L++ + +VE L + + L K+ +K+++
Sbjct: 1408 EAVNAKCASLEKT----KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLS------ 1457
Query: 556 AVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAV 615
E K+ E + LEA++K E + ++ ++K E+ LR+
Sbjct: 1458 ---EWKQKYEETQAELEASQK---------ESRSLSTELFKVKNVYEESLDQLETLRREN 1505
Query: 616 KILEKGIENLES----------ENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEV 665
K L++ I +L E +K+KK +V K EI A ++ A G +
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKK--QVEQEKCEIQAALEEAEASLEHEEGKILR 1563
Query: 666 LKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVE 725
++ ++ K EV+R E EE + + + + AE R +A ++ ++E
Sbjct: 1564 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDA-LRVKKKME 1622
Query: 726 KQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQ 785
+ ++E++ H +LA E + T+ E + L + + + +K+
Sbjct: 1623 GDLNEMEIQLNHAN--------RLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQL 1674
Query: 786 ERSESELDKKTADMEK-----QQAEEQKKLAEDKLLLLGDSLQL 824
E + A++E+ +Q E +K+AE +LL + +QL
Sbjct: 1675 AIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Score = 95.5 bits (236), Expect = 5e-19
Identities = 118/469 (25%), Positives = 221/469 (46%), Gaps = 44/469 (9%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++ +K E +K K ++ + +A+ K +L++K +++ +N L+ V+ +
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRK---ELEEKMVTLLKEKNDLQLQVQSEADSLA 902
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSA--------LKSESTKLK 464
+ E ++L K+ KI++E K++ A E E++A L+ E ++LK
Sbjct: 903 DAEERCEQLIKN--------KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK 954
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLK 524
KDI + + + +EK A EN+V L E+A L + S+E E +
Sbjct: 955 KDIDDLELTLAKVEKEK-------HATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 525 AGISDTEKE---VNTLKKELVEKEKIVADSERKTAVDERKKAAAE-ARKLLEAAKKIAPE 580
+ D + E VN L K + E+ V D E +++ + E A++ LE K+A E
Sbjct: 1008 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 581 KAVIPEPANCCSKCDE-LKKKCEKVA--VGRNALRQAVKI-LEKGIENLESENKKLKKEN 636
+ E N + DE L+KK +++ + + QAV+I L+K I+ L++ ++L +
Sbjct: 1068 STMDME--NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGE-- 1123
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER 696
E+ A ++ + +++ +RE E L+ T +V KK E +++ D E
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE 1183
Query: 697 KTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKT 756
T E AA L + AE+ +QI ++ + LEK+ +E KM+ +LS
Sbjct: 1184 ATLQHEAMVAA-----LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKME-TDDLSSN 1237
Query: 757 KEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAE 805
EA + + +K+ + S++K +E + ++ TA + Q E
Sbjct: 1238 AEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTE 1286
Score = 93.2 bits (230), Expect = 2e-18
Identities = 120/527 (22%), Positives = 238/527 (44%), Gaps = 49/527 (9%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
+ L+ + E +++ A L+K N + + K+ +E QA+ + + + +S
Sbjct: 1422 QRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLS 1481
Query: 79 NTFAALEN-------EVSALISENKKLKQDILEEQAQ----GKICDQLKKCEKVVEGRNA 127
++N ++ L ENK L+Q+I + Q GK +L+K +K VE
Sbjct: 1482 TELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC 1541
Query: 128 LRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKL-EKSNAFAALE-NEVSALK 185
QA LE+ +LE E K+ + IQ E Q K E++ K+ EK L+ N ++
Sbjct: 1542 EIQAA--LEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 186 SENKKLKKDI--LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQ 243
+ L +I + + K MEG L N ++A N + Q IL E
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKE--- 1655
Query: 244 GKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGK 303
+ + + G+ L++ + I+E+ L++E ++L +++ RK+ +
Sbjct: 1656 ------TQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709
Query: 304 LEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK 363
L+ S L + ++L + KKL+ D+ + Q++ + ++ E NA E +
Sbjct: 1710 LDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQ---ESRNA----EEKAKKAI 1762
Query: 364 SENKKLKQDILEEQAQGKFCDQLKKKCEKVVEG-RNALRQAVKILEKG----IENLESEN 418
++ + +++ +EQ +++KK E+ V+ ++ L +A ++ KG I+ LE+
Sbjct: 1763 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822
Query: 419 KKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKV-- 476
++L+ +++ EQ + ++G + L + + +L+ + + QA++K
Sbjct: 1823 RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882
Query: 477 -AIEEKLEISNA----FAALENEVSAL--KSEIAALQ-QKCGAGSRE 515
EE E SNA F L++E+ +++IA Q K SRE
Sbjct: 1883 RQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1929
Score = 84.7 bits (208), Expect = 9e-16
Identities = 115/595 (19%), Positives = 256/595 (42%), Gaps = 107/595 (17%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
EELK + E+ +NAL A +++ + L++ +EEQ EGK E+
Sbjct: 1316 EELKHQLEEETKAKNALAHA-------LQSSRHDCDLLREQYEEEQ-------EGKAELQ 1361
Query: 79 NTFAALENEVSALIS--ENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ +EV+ + E +++ E+A+ K+ +L++ E+ VE NA +++ +
Sbjct: 1362 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTK 1421
Query: 137 KRIEN------------------LESENKKLKKDIQE-----EQAQRKIEIEGKLEKS-- 171
+R++N L+ + + K + E E+ Q ++E K +S
Sbjct: 1422 QRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLS 1481
Query: 172 -------NAFAALENEVSALKSENKKLKKDILEEQAQ-----------RKVAMEGKLEIS 213
N + +++ L+ ENK L+++I + Q K+ + + E
Sbjct: 1482 TELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC 1541
Query: 214 NAFAALENEVSALKSENKKLKQDILD-EQAQGKFCDRLKKKCEKVVEGRNALRQAVKILE 272
AALE ++L+ E K+ + L+ Q + + ++ +K E++ + + + V+ ++
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQ 1601
Query: 273 KGIE-NLESEN------KKLKKDIQE-----EHAQRKVE--------------------- 299
++ + S N KK++ D+ E HA R
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLD 1661
Query: 300 --IEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 357
+ G+ ++ A +E + L++E ++L + + + RK+A + L+ S L
Sbjct: 1662 DALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHT 1721
Query: 358 EVSALKSENKKLKQDILEEQAQGKFCDQ----LKKKCEKVVEGRNALRQAVKILEKGIEN 413
+ ++L + KKL+ D+ + Q++ + Q ++K +K + + + +K + +
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 414 LESENKKLK---KDIQE--EQAQRKIEIEGKLEISNAFA---ALENEVSALKSESTKLKK 465
LE K L+ KD+Q ++A++ GK +I A LE EV + + + K
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841
Query: 466 DILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDV 520
+ + + ++K + E L++ V L++++ + +++ + N ++
Sbjct: 1842 GLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANL 1896
Score = 62.4 bits (150), Expect = 5e-09
Identities = 62/296 (20%), Positives = 140/296 (46%), Gaps = 27/296 (9%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
+E + + + G+ L++ + I+E+ L++E ++L +++ + RK+A + L+ S
Sbjct: 1654 KETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDAS 1713
Query: 79 NTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKR 138
L + ++LI+ KKL+ D+ + Q++ + E + E RNA +A K +
Sbjct: 1714 ERVQLLHTQNTSLINTKKKLENDVSQLQSEVE--------EVIQESRNAEEKAKKAITDA 1765
Query: 139 IENLESENKKLKKDIQEEQAQRKIE-----IEGKLEKSNAFAAL--ENEVSALKSENKKL 191
E K+ E+ ++ +E ++ +L+++ A + ++ L++ ++L
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1825
Query: 192 KKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE-QAQGKFCDRL 250
+ ++ EQ + A++G + L + + +L QD++D+ QA+ K
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRL-QDLVDKLQAKVK---SY 1881
Query: 251 KKKCEKVVEGRNA-------LRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVE 299
K++ E+ E NA L+ ++ E+ + ES+ KL+ +E H + E
Sbjct: 1882 KRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
>MYH9_HUMAN (P35579) Myosin heavy chain, nonmuscle type A (Cellular
myosin heavy chain, type A) (Nonmuscle myosin heavy
chain-A) (NMMHC-A)
Length = 1960
Score = 137 bits (344), Expect = 2e-31
Identities = 190/882 (21%), Positives = 397/882 (44%), Gaps = 106/882 (12%)
Query: 15 CSKCEEL-------KKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQ------ 61
C++ EEL K++ E++ + L V+ E+ ++L++E KK++++IQ
Sbjct: 896 CAEAEELRARLTAKKQELEEIC---HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 62 --EEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQD--ILEE---QAQGKICDQ 114
EE A++K+ +E K+ LE E L +N KL ++ +LE+ + + ++
Sbjct: 953 EEEESARQKLQLE-KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 115 LKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAF 174
+K + + + +N + LE+R+ E + ++L E+ +RK+E + + S+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL------EKTRRKLEGD-STDLSDQI 1064
Query: 175 AALENEVSALKSENKKLKKD-------ILEEQAQRKVAMEGKLEISNAFAALENEV-SAL 226
A L+ +++ LK + K +++ + EE AQ+ +A++ E+ + + L+ ++ S
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 227 KSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-------RNALRQAVKILEKGIENLE 279
S NK KQ ++ G+ + LK + E ++ R+ Q V IL+K +E
Sbjct: 1125 ASRNKAEKQ----KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 280 SENKKLKKDIQEEHAQRKVEIEGKLE--------ISNAFAALENEVSALKSENKKLKKDI 331
++ ++++++H+Q E+ +LE + A LENE L +E K L +
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 332 LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCE 391
+ + +RK E+ F E + L + KL+ ++ + G Q K
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL--DNVTG-LLSQSDSKSS 1297
Query: 392 KVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALEN 451
K+ + +AL ++ ++ ++ + L +++ + ++ E E A LE
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 452 EVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGA 511
+++ L ++ +KK + + ++ A E K ++ L S E A K
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL----SQRHEEKVAAYDKLEK 1413
Query: 512 GSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERKKAAAEARK 569
+++ L + + L+K+ + ++++A+ + +A +ER +A AEAR+
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 570 -------LLEAAKKIAPEKAVI--------PEPANCCSKCDELKKKCEKVAVGRNALRQA 614
L A ++ +KA + E + S D++ K ++ + AL Q
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 615 VKILEKGIENLE-----SENKKLKKENEVSALKS----EISALQQKCGAGAREGNGDVEV 665
V+ ++ +E LE +E+ KL+ E + A+K+ ++ ++ ++ V
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 666 LKAGISDTKKEVNRLKKEHVEEERIVADSER--KTAVDERKNAAAEARKLLEAPKKIAAE 723
++A + D +K+ + + E + D E +A R A + RKL K E
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 724 VEKQIAKVELRQVHLEKQVNERKMK--------LAFELSKTKEATKRFEAEKKKLLVEKI 775
++ A E ++ + + NE+K+K L EL+ + A ++ + E+ +L E
Sbjct: 1654 LDDTRASRE--EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 776 NAESKIKKAQERSESELDKKTADMEKQQAEEQ--KKLAEDKL 815
N+ K A E + L+ + A +E++ EEQ +L D+L
Sbjct: 1712 NSSGKGALALE-EKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Score = 119 bits (298), Expect = 3e-26
Identities = 211/980 (21%), Positives = 415/980 (41%), Gaps = 192/980 (19%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
++ EE +++C+ + + ++Q ++ LE+ +E ES +KL+ + +A+ K E ++
Sbjct: 922 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEK--VVEGRNALRQAVK 133
+ + L E L + ++ EE+ + K +LK + + + LR+ K
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 134 I---LEKRIENLESENKKLKKDIQEEQAQ----------RKIEIEGKLEKSNAFAALEN- 179
LEK LE ++ L I E QAQ ++ E++ L + AA +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 180 ---EVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEV-------SALKSE 229
++ L+S+ +L++D+ E+A R A + K ++ AL+ E+ +A +
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 230 NKKLKQDI------LDEQA---QGKFCDRLKKKCEKVVEGRNALRQAVKI---LEKGIEN 277
K +Q++ L+E+A + + + +K + V E L Q ++ LEK +
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 278 LESENKKLKKDIQ--------EEHAQRKVEI----------EG---KLEISNAFAALENE 316
LE+E +L +++ EH ++KVE EG + E+++ L+ E
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 317 V-------SALKSENKKLKKD-------------ILEEQAQRKVAMEGKL---------- 346
+ S S++ KL KD +L+E+ ++K+++ KL
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 347 -----EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALR 401
E A LE +++ L ++ +K+ + + + +++K+K +K +EG +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 402 Q----AVKILEKGIENLESENKKLKKDIQE--------EQAQRKIE--IEGKLEISNAFA 447
+ A LEK L+ E L D+ E+ Q+K + + + IS +A
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 448 ---------ALENEVSALK-----SESTKLKKDILEEQAQIKVAIEEKL----------- 482
A E E AL E+ + K ++ Q + +E+ +
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 483 EISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEV-LKAGISDTEKEVNTLKKEL 541
E+ + ALE +V +K+++ L+ + A + + +EV L+A + E+++ ++
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQA-TEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 542 VEKEKIVADSERKTAV---DERKKA--AAEARKLLEAAKK----------------IAPE 580
EK+K + R+ DERK+ A ARK LE K I
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 581 KAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE-----SENKKLKKE 635
+ + + +C + D+ + E++ + +K +E + L+ +E K + +
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 636 NEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEV--------NRLKKEHVEE 687
E L EI+ K GA A E +E A + + +E +RLKK +++
Sbjct: 1701 QERDELADEIANSSGK-GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759
Query: 688 ERIVADSE-RKTAVDERKNAAAEAR--------KLLEAPKKIAAEVEKQIAKVELRQVHL 738
++I D ++ + +NA + KL E + ++ + I +E + L
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 739 EKQV-NERKMKLAF--ELSKTKEATK---------RFEAEKKKLLVEKINAESK-IKKAQ 785
E+Q+ NE K + A ++ +T++ K R AE+ K +K + K +K+
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879
Query: 786 ERSESELDKKTADMEKQQAE 805
E +E E + A K Q E
Sbjct: 1880 EEAEEEAQRANASRRKLQRE 1899
Score = 112 bits (281), Expect = 3e-24
Identities = 177/826 (21%), Positives = 364/826 (43%), Gaps = 121/826 (14%)
Query: 21 LKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNT 80
L+K + + R L VK+L +G + E + KK++ +QE Q + + E+++
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 81 FAALENE---VSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEK 137
L+ E V+ L+S++ + ++ + + QL+ +++++ N RQ + L
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFS--ALESQLQDTQELLQEEN--RQKLS-LST 1329
Query: 138 RIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAA-----LENEVSALKSE---NK 189
+++ +E E ++ ++EE+ + K +E ++ +A A +E+ V L++ +
Sbjct: 1330 KLKQVEDEKNSFREQLEEEE-EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR 1388
Query: 190 KLKKDI--LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFC 247
KL+KD+ L ++ + KVA A+ LE + L+ E L D LD Q Q C
Sbjct: 1389 KLQKDLEGLSQRHEEKVA---------AYDKLEKTKTRLQQELDDLLVD-LDHQRQSA-C 1437
Query: 248 DRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGK---- 303
+ KK +K + L +E K + EE + + E K
Sbjct: 1438 NLEKK-------------------QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 304 LEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK 363
L ++ A + + L+ NK+ + ++ + + + + E+ + ALE +V +K
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 364 SENKKLKQDILEEQAQGKF-----CDQLKKKCEKVVEGRNALRQAVKILEKGIENLESEN 418
++ ++L +D L+ K +K + E+ ++GR+ + K + L +
Sbjct: 1539 TQLEEL-EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK------KQLVRQV 1591
Query: 419 KKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAI 478
++++ ++++E+ QR + + + ++ LE + + + K + + QAQ+K +
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 479 EE-------KLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTE 531
E + EI E ++ ++++E+ LQ++ A R +
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER---------------AK 1696
Query: 532 KEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAP-EKAVIPEPANC 590
++ + EL ++ +A+S K A+ A E ++ LEA +IA E+ + E N
Sbjct: 1697 RQAQQERDELADE---IANSSGKGAL------ALEEKRRLEA--RIAQLEEELEEEQGNT 1745
Query: 591 CSKCDELKK---KCEKVAVGRNALRQAVKILEKGIENLESENKKLK-KENEV-----SAL 641
D LKK + +++ N R + E + LE +NK+LK K E+ S
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805
Query: 642 KSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVD 701
K+ I+AL+ K + + + + +A K+V R +K+ +++ + D ER+ A
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAAC----KQVRRTEKK-LKDVLLQVDDERRNAEQ 1860
Query: 702 ERKNAAAEARKLLEAPKKI-AAEVEKQIAKVELRQVHLE-KQVNERKMKLAFELSKTKEA 759
+ A + +L + +++ AE E Q A R++ E + E + E+S K
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Query: 760 TKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAE 805
+R + L + K A + S+ E+D K E + AE
Sbjct: 1921 LRRGD------LPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE 1960
Score = 87.4 bits (215), Expect = 1e-16
Identities = 115/558 (20%), Positives = 254/558 (44%), Gaps = 99/558 (17%)
Query: 328 KKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLK 387
+++++ ++ + E +L N +E S L +E +L++ + QA+ + C + +
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL---QAETELCAEAE 900
Query: 388 KKCEKVVEGRNALRQAVKILEKGIE-------NLESENKKLKKDIQE--------EQAQR 432
+ ++ + L + LE +E +L++E KK++++IQE E A++
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 433 KIEIEGKLEISNAFAALENEVSALKSESTKLKKD--ILEEQ-AQIKVAIEEKLEISNAFA 489
K+++E K+ LE E L+ ++ KL K+ +LE++ A+ + E+ E S + A
Sbjct: 961 KLQLE-KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 490 ALENEVSALKSEIAAL-------QQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELV 542
L+N+ A+ +++ +Q+ R+ GD L I++ + ++ LK +L
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 543 EKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCE 602
+KE+ E + A+ ++ AA+ L+ +++ S+ EL++ E
Sbjct: 1080 KKEE-----ELQAALARVEEEAAQKNMALKKIRELE-------------SQISELQEDLE 1121
Query: 603 KVAVGRNALRQAVKILEKGIENLESE-----NKKLKKENEVSALKSEISALQQKCGAGAR 657
RN + + L + +E L++E + ++ S + E++ L++ A+
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 658 EGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER--KTAVDERKNAAAEARKLLE 715
++ ++ S +E L ++ + +R+ A+ E+ +T +ER A E + LL+
Sbjct: 1182 THEAQIQEMRQKHSQAVEE---LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 716 AP-------KKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFEL-----------SKTK 757
KK+ A++++ K + + ++ ++ KL EL SK+
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGE-RVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 758 EATKRFEA------EKKKLLVE----KINAESKIKKAQERSES-------------ELDK 794
+ TK F A + ++LL E K++ +K+K+ ++ S L+K
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 795 KTADMEKQQAEEQKKLAE 812
+ A + Q A+ +KK+ +
Sbjct: 1358 QIATLHAQVADMKKKMED 1375
Score = 87.0 bits (214), Expect = 2e-16
Identities = 130/629 (20%), Positives = 262/629 (40%), Gaps = 123/629 (19%)
Query: 290 QEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 349
QEE K E +++ A EN ++ +++ +L + L+ Q Q + E E
Sbjct: 843 QEEEMMAKEE--ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900
Query: 350 NAFAAL---------------------ENEVSALKSENKKLKQDI--LEEQAQGKFCDQL 386
A L E L++E KK++Q+I LEEQ + + +
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 387 KKKCEKV---------------VEGRNA-LRQAVKILE-----------------KGIEN 413
K + EKV +E +N L + K+LE K +
Sbjct: 961 KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 414 LESENKKLKKDIQE------------EQAQRKIEIEGKLEISNAFAALENEVSALKSEST 461
L+++++ + D++E E+ +RK+E + ++S+ A L+ +++ LK +
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD-STDLSDQIAELQAQIAELKMQLA 1079
Query: 462 KLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEI---AALQQKCGAGSREGNG 518
K ++++ A+++ +K LE+++S L+ ++ A + K R+
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 519 DVEVLKAGISDT--------------EKEVNTLKKELVEKEKIVADSERKTAVDERKKAA 564
++E LK + DT E+EVN LKK L E+ K +++ + + +A
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK-THEAQIQEMRQKHSQAV 1198
Query: 565 AEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIEN 624
E + LE K++ L+K + + R L VK+L +G +
Sbjct: 1199 EELAEQLEQTKRVKA----------------NLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 625 LESENKKLK--------KENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKE 676
E + KK++ K NE +++E++ K G + + S K+
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 677 VNRLKKEHVEEERIVADSERK-----TAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKV 731
+ L+ + + + ++ + R+ T + + ++ R+ LE ++ +EKQIA +
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 732 ELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESE 791
+ ++K++ + L ++ K E ++ EK+ A K++K + R + E
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR-HEEKVAAYDKLEKTKTRLQQE 1421
Query: 792 LDKKTADMEKQQAE----EQKKLAEDKLL 816
LD D++ Q+ E+K+ D+LL
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Score = 70.5 bits (171), Expect = 2e-11
Identities = 85/444 (19%), Positives = 189/444 (42%), Gaps = 89/444 (20%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
+ +K + E+ + GR+ + K + L + ++++ ++++E+ QR +A+ + ++
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKK------KQLVRQVREMEAELEDERKQRSMAVAARKKLE 1616
Query: 79 NTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKR 138
LE + S NK + I + + K+ Q+K C + ++ A R+ + K
Sbjct: 1617 MDLKDLEAHID---SANKNRDEAIKQLR---KLQAQMKDCMRELDDTRASREEILAQAK- 1669
Query: 139 IENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEE 198
EN+K K ++ E Q + E+ AA E + E +L +I
Sbjct: 1670 ------ENEKKLKSMEAEMIQLQEEL----------AAAERAKRQAQQERDELADEIANS 1713
Query: 199 QAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKK---KCE 255
+ +A+E K + A LE E+ + + + DRLKK + +
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN-------------DRLKKANLQID 1760
Query: 256 KVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALEN 315
++ N R + E + LE +NK+LK +Q E+EG ++ + +
Sbjct: 1761 QINTDLNLERSHAQKNENARQQLERQNKELKVKLQ--------EMEGTVK-----SKYKA 1807
Query: 316 EVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILE 375
++AL+++ +L++ + E +R+ A + ++ KKLK +L+
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACK-----------------QVRRTEKKLKDVLLQ 1850
Query: 376 EQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIE 435
+ + +Q K + +K L++ ++ E+ + + +KL+++++
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE--------- 1901
Query: 436 IEGKLEISNAFAALENEVSALKSE 459
+ + A+ EVS+LK++
Sbjct: 1902 -----DATETADAMNREVSSLKNK 1920
>MYHA_BOVIN (Q27991) Myosin heavy chain, nonmuscle type B (Cellular
myosin heavy chain, type B) (Nonmuscle myosin heavy
chain-B) (NMMHC-B)
Length = 1976
Score = 136 bits (342), Expect = 3e-31
Identities = 186/878 (21%), Positives = 393/878 (44%), Gaps = 108/878 (12%)
Query: 12 ANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR---- 67
A +K +EL++ + + +IL+ + +++ + L++ + EE+ R
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 68 --KVAIEGKL-EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEG 124
KV E K+ ++ LE++ S I E KKL +D + E ++ ++ +K + + +
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKE-KKLMEDRIAE-CSSQLAEEEEKAKNLAKI 1028
Query: 125 RNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSAL 184
RN + LE+R++ E ++L E+A+RK++ E + + A L+ ++ L
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQEL------EKAKRKLDGE-TTDLQDQIAELQAQIDEL 1081
Query: 185 KSENKKLKKDI-----------LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL 233
K + K ++++ L + KV E + +I+ E+E A +++ +K
Sbjct: 1082 KIQVAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQ 1140
Query: 234 KQDILDEQAQGKFCDRLKKKCEKVV-------EGRNALRQAVKILEKGIENLESENKKLK 286
K+D+ +E + LK + E + E R Q V L+K +E ++
Sbjct: 1141 KRDLSEE------LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKSHEAQI 1194
Query: 287 KDIQEEHAQRKVEIEGKLEISNAFAA-LENEVSALKSENKKLKKDILEEQAQRKVAMEGK 345
+D+++ HA E+ +LE + F A LE L+++NK+L ++ KV + K
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV-------KVLQQVK 1247
Query: 346 LEISNAFAALENEVSALK---SENKKLKQDILEEQAQ--------GKFCDQLKKKCEKVV 394
E + L+ +V L SE +L+ ++ E+ + ++ +KK K
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 395 EGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVS 454
+ L ++ ++ ++ + L I++ + +R E + E A +LE ++
Sbjct: 1308 KDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEERSSLQEQQEEEEEARRSLEKQLQ 1367
Query: 455 ALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSR 514
AL+++ T KK + ++ I+ E K ++ L + E A K
Sbjct: 1368 ALQAQLTDTKKKVDDDLGTIENLEEAKKKLLKDVEVLSQRL----EEKALAYDKLEKTKT 1423
Query: 515 EGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERKKAAAEAR---- 568
+++ L + + V+ L+K+ + ++++A+ + +A +ER +A AEAR
Sbjct: 1424 RLQQELDDLLVDLDHQRQIVSNLEKKQKKFDQLLAEEKNISARYAEERDRAEAEAREKET 1483
Query: 569 ------KLLEAAKKIAPE-----KAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKI 617
+ LE A + E K + + + S D++ K ++ + AL Q V+
Sbjct: 1484 KALSLARALEEALEAREEAERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 618 LEKGIENLE-----SENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISD 672
+ +E LE +E+ KL+ E + A+K++ Q E N + + L
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT----RDEQNEEKKRLLI---- 1595
Query: 673 TKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL---LEAPKKIAAEVEKQIA 729
K+V L+ E +E+ER +R AV +K + + L +EA K EV KQ+
Sbjct: 1596 --KQVRELEAE-LEDER----KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 730 KVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL--LVEKINAESKIKKAQER 787
K++ + ++++ E + +++KE+ K+ ++ + ++ L E++ + + ++ E+
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 788 SESELDKKTADME--KQQAEEQKKLAEDKLLLLGDSLQ 823
EL + A+ K ++K+ E ++ L + L+
Sbjct: 1709 ERDELADEIANSASGKSALLDEKRRLEARIAQLEEELE 1746
Score = 131 bits (330), Expect = 6e-30
Identities = 203/875 (23%), Positives = 379/875 (43%), Gaps = 120/875 (13%)
Query: 12 ANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQE-EQAQRKVA 70
A C S+ E ++K + + RN +Q V I +LE KK +K QE E+A+RK+
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRN--KQEVMI-----SDLEERLKKEEKTRQELEKAKRKLD 1061
Query: 71 IEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQ 130
E ++ + A L+ ++ L K++ EE+ QG + + ++ + NAL
Sbjct: 1062 GE-TTDLQDQIAELQAQIDEL-----KIQVAKKEEELQGALA---RGDDETLHKNNAL-- 1110
Query: 131 AVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKK 190
K + L+++ +L++D + E+A R K EK L E+ ALK+E
Sbjct: 1111 ------KVVRELQAQIAELQEDFESEKASRN-----KAEKQKR--DLSEELEALKTE--- 1154
Query: 191 LKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ------DILDEQAQG 244
L+ + AQ+++ + + E++ ALE E + +++ + ++Q + L EQ +
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEEETKSHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 245 --KFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEG 302
+F L+K + + L VK+L++ E + KKL +QE HA+
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 303 KLEISNAFAALENE---VSALKSENKK-----------LKKDILEEQAQRKVAMEGKLEI 348
++E++ L+NE VS L E +K L+ + + Q + KL +
Sbjct: 1275 RVELAEKANKLQNELDNVSTLLEEAEKKGIKFAKDAAGLESQLQDTQELLQEETRQKLNL 1334
Query: 349 SNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILE 408
S+ LE E S+L+ + ++ EE+A+ QL+ ++ + + + +
Sbjct: 1335 SSRIRQLEEERSSLQEQQEE------EEEARRSLEKQLQALQAQLTDTKKKVDDDLGT-- 1386
Query: 409 KGIENLESENKKLKKDIQ------EEQA-----QRKIEIEGKLEISNAFAALENEVSALK 457
IENLE KKL KD++ EE+A K + + E+ + L+++ +
Sbjct: 1387 --IENLEEAKKKLLKDVEVLSQRLEEKALAYDKLEKTKTRLQQELDDLLVDLDHQRQIVS 1444
Query: 458 SESTKLKK--DILEEQAQIKVAIEEKLEISNAFAALENEVSALK-----SEIAALQQKCG 510
+ K KK +L E+ I E+ + + A A E E AL E +++
Sbjct: 1445 NLEKKQKKFDQLLAEEKNISARYAEERDRAEA-EAREKETKALSLARALEEALEAREEAE 1503
Query: 511 AGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKL 570
+++ D+E L + D K V+ L+K E+ V + + E + A E KL
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 571 -----LEAAKKIAPEKAVIPEPAN------CCSKCDELKKKCEKVAVGRNALRQAVKILE 619
++A K + N + EL+ + E R + K +E
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 620 KGIENLESENKKLKK-ENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVN 678
+++LE++ + K +EV ++ A + E + + A +++K++
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 679 RLKKEHV---------EEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAA------- 722
L+ E + E R A+ ER DE N+A+ LL+ +++ A
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEE 1743
Query: 723 EVEKQIAKVELRQVHLEK---QVNERKMKLAFELS---KTKEATKRFEAEKKKLLVEKIN 776
E+E++ + +EL K QV+ +LA E S K+ A ++ E + K+L +
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQE 1803
Query: 777 AESKIKKAQERSESELDKKTADMEKQQAEEQKKLA 811
E +K + + S L+ K +E+Q +E K+ A
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Score = 113 bits (283), Expect = 2e-24
Identities = 143/680 (21%), Positives = 305/680 (44%), Gaps = 70/680 (10%)
Query: 17 KCEELKKKCEQV-VVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
K +L+ + + V + A ++ +K K LES+ + ++ +QEE Q KL
Sbjct: 1281 KANKLQNELDNVSTLLEEAEKKGIKFA-KDAAGLESQLQDTQELLQEETRQ-------KL 1332
Query: 76 EISNTFAALENEVSALISENKKLKQD--ILEEQAQG----------KICDQLKKCEKVVE 123
+S+ LE E S+L + ++ ++ LE+Q Q K+ D L E + E
Sbjct: 1333 NLSSRIRQLEEERSSLQEQQEEEEEARRSLEKQLQALQAQLTDTKKKVDDDLGTIENLEE 1392
Query: 124 GRNALRQAVKILEKRIEN-------LESENKKLKKDIQE------EQAQRKIEIEGKLEK 170
+ L + V++L +R+E LE +L++++ + Q Q +E K +K
Sbjct: 1393 AKKKLLKDVEVLSQRLEEKALAYDKLEKTKTRLQQELDDLLVDLDHQRQIVSNLEKKQKK 1452
Query: 171 SNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSEN 230
+ A E +SA +E + + E+ + +++ LE ALE A + +N
Sbjct: 1453 FDQLLAEEKNISARYAEERDRAEAEAREKETKALSLARALE-----EALEAREEA-ERQN 1506
Query: 231 KKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENK------- 283
K+L+ D+ D + D + K ++ + + AL Q V+ + +E LE E +
Sbjct: 1507 KQLRADMEDLMSSK---DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 284 KLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAME 343
+L+ ++Q AQ + +++ + E + E + L + ++L+ ++ +E+ QR +A+
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQN------EEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 344 GKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQA 403
K ++ LE ++ A ++ + + + QAQ K +++ E+ R+ +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK---DYQRELEEARASRDEIFAQ 1674
Query: 404 VKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL 463
K EK +++LE+E +L++++ + R+ + + E+++ A + SAL E +L
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRL 1734
Query: 464 KKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAA---LQQKCGAGSREGNGDV 520
+ I + + +++ +++ F +V L +E+AA QK ++
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQN 1794
Query: 521 EVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPE 580
+ LKA + + E V + K + + + E K+ AA + + KK+
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL--- 1851
Query: 581 KAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVS- 639
K + + + D+ K++ EK L++ ++ E+ + +KL++E + +
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDAT 1911
Query: 640 ----ALKSEISALQQKCGAG 655
L E+S L+ + G
Sbjct: 1912 EANEGLSREVSTLKNRLRRG 1931
Score = 65.9 bits (159), Expect = 4e-10
Identities = 66/332 (19%), Positives = 152/332 (44%), Gaps = 56/332 (16%)
Query: 7 VIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 66
VI + ++ ++ +++ E+ R+ + K EK +++LE+E +L++++ +
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 67 RKVAIEGKLEISNTFAALENEVSALISENKK-------LKQDILEEQAQGKIC-DQLKKC 118
R+ A + + E+++ A + SAL+ E ++ L++++ EEQ+ ++ D+ +K
Sbjct: 1703 RRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 119 EKVVEGRN----ALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAF 174
V+ N A R A + + + LE +NK+LK +QE + K + + +
Sbjct: 1763 TLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI------ 1816
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
+ALE ++ L+ + LE++A+ + A ++ KKLK
Sbjct: 1817 SALEAKIGQLEEQ--------LEQEAKERAAAN----------------KLVRRTEKKLK 1852
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHA 294
+ + + + + D+ K++ EK L++ ++ E+ + +KL++++
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD---- 1908
Query: 295 QRKVEIEGKLEISNAFAALENEVSALKSENKK 326
+ + A L EVS LK+ ++
Sbjct: 1909 ----------DATEANEGLSREVSTLKNRLRR 1930
Score = 56.6 bits (135), Expect = 3e-07
Identities = 100/483 (20%), Positives = 208/483 (42%), Gaps = 80/483 (16%)
Query: 354 ALENEVSALKSENKKLKQDIL--EEQAQGKFCDQL---KKKCEKVVEGRNALRQAVKILE 408
+L ++ L++ N + I+ E+ GK L + +C V+EG ++I
Sbjct: 660 SLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEG-------IRICR 712
Query: 409 KGIEN-LESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL--KK 465
+G N + + + + +I A K ++GK ALE + + + +K+ +
Sbjct: 713 QGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRA 772
Query: 466 DIL---EEQAQIKV--------AIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSR 514
+L EE+ +K+ A+ AFA + ++SALK LQ+ C A +
Sbjct: 773 GVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK----VLQRNCAAYLK 828
Query: 515 EGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK-KAAAEARKLLEA 573
+ + +V L + ++E++ A E V E++ K E ++
Sbjct: 829 LRHWQWWRVFT-------KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK 881
Query: 574 AKKIAPEKAVIPEPANCCSKC-DELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL 632
+++ EK ++ E ++ E ++ ++A + L + + LE +E E N+ L
Sbjct: 882 HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
+NE +++ I L+++ E G + L+ +K K + +EEE ++
Sbjct: 942 --QNEKKKMQAHIQDLEEQLD----EEEGARQKLQL-----EKVTAEAKIKKMEEEILLL 990
Query: 693 DSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFE 752
+ + + E+K L+E AE Q+A+ E + +L K N++++ ++
Sbjct: 991 EDQNSKFIKEKK--------LMEDR---IAECSSQLAEEEEKAKNLAKIRNKQEVMISD- 1038
Query: 753 LSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAE 812
L E++ E K ++ E+++ +LD +T D++ Q AE Q ++ E
Sbjct: 1039 ------------------LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 813 DKL 815
K+
Sbjct: 1081 LKI 1083
Score = 52.4 bits (124), Expect = 5e-06
Identities = 50/165 (30%), Positives = 82/165 (49%), Gaps = 15/165 (9%)
Query: 662 DVEVLKAGISDTK-----KEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEA 716
D E+LK TK +E+ R ++ +EE+ I+A E+ A E A E R L A
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA--EQLQAETELFAEAEEMRARLAA 915
Query: 717 PKKIAAEVEKQI-AKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKI 775
K+ E+ + ++VE + + NE+K K+ + +E E ++KL +EK+
Sbjct: 916 KKQELEEILHDLESRVEEEEERNQILQNEKK-KMQAHIQDLEEQLDEEEGARQKLQLEKV 974
Query: 776 NAESKIKKAQER------SESELDKKTADMEKQQAEEQKKLAEDK 814
AE+KIKK +E S+ K+ ME + AE +LAE++
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/202 (22%), Positives = 94/202 (45%), Gaps = 31/202 (15%)
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
KK+ ++SALK LQ+ C A + + + + + + ++ ++E ++
Sbjct: 808 KKQQQLSALK----VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLK 863
Query: 693 DSERKTAVD--------------ERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHL 738
E++T V+ E KN AE L+A ++ AE E+ A++ ++ L
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQ---LQAETELFAEAEEMRARLAAKKQEL 920
Query: 739 EKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTAD 798
E+ +++ + ++ E +E + + EKKK+ + E ++ E E ++
Sbjct: 921 EEILHDLESRVEEE----EERNQILQNEKKKMQAHIQDLEEQL------DEEEGARQKLQ 970
Query: 799 MEKQQAEEQKKLAEDKLLLLGD 820
+EK AE + K E+++LLL D
Sbjct: 971 LEKVTAEAKIKKMEEEILLLED 992
>MYH3_HUMAN (P11055) Myosin heavy chain, fast skeletal muscle,
embryonic (Muscle embryonic myosin heavy chain) (SMHCE)
Length = 1940
Score = 135 bits (340), Expect = 4e-31
Identities = 167/833 (20%), Positives = 362/833 (43%), Gaps = 88/833 (10%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E L + I + ++K E +
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 77 ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ A E++V++L KL+Q + E + + + K + + L +K+ +
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQV--EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ 1064
Query: 137 KRIENLESENKKL-----KKDIQEEQAQRKIEIEGKL---------EKSNAFAALENEVS 182
+ I +LE++ ++L KKD + Q Q K+E E L E LE E+
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 183 ALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK-SENKKLKQDILDE- 240
A ++ K +K + A+ + +LE + + + E++ + +E KL++D+ +
Sbjct: 1125 AERATRAKTEKQ-RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183
Query: 241 -QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVE 299
Q + KK + V E L + + L++ + LE E + K +I + + +
Sbjct: 1184 LQHEAMVATLRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 300 IEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEV 359
+ K + LE+++S + +N+++++ + E Q+ E+S E+ V
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Query: 360 SALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENK 419
S L + Q ++LK++ E+ + +NAL A +++ +
Sbjct: 1300 SQLSRSKQAFTQQ----------TEELKRQLEEENKAKNALAHA-------LQSSRHDCD 1342
Query: 420 KLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIE 479
L++ +EEQ EGK E+ A + +EV+ + TK + D ++ +++ E
Sbjct: 1343 LLREQYEEEQ-------EGKAELQRALSKANSEVAQWR---TKYETDAIQRTEELE---E 1389
Query: 480 EKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKK 539
K +++ E +V A+ ++ A+L++ + G+VE L + L K
Sbjct: 1390 AKKKLAQRLQDSEEQVEAVNAKCASLEKT----KQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 540 ELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEP-ANCCSKCDELK 598
+ +K++A E KT +E + AE L+ ++ ++ E + + + +K
Sbjct: 1446 KQRNFDKVLA--EWKTKCEE---SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
Query: 599 KKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGARE 658
++ +N ++ + E+ EN ++ ++ K ++ K++I ++ A
Sbjct: 1501 RE------NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554
Query: 659 GNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPK 718
+ ++ ++ K E++R E EE + + ++T + AE R EA
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEA-I 1613
Query: 719 KIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTK-------EATKRFEAEKKKLL 771
++ ++E + ++E++ H +Q E L + K +A + E K++L
Sbjct: 1614 RLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLA 1673
Query: 772 VEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQL 824
+ +++ ++E+++ A +E Q E +KLAE +LL + +QL
Sbjct: 1674 I--------VERRANLLQAEVEELRATLE--QTERARKLAEQELLDSNERVQL 1716
Score = 91.3 bits (225), Expect = 9e-18
Identities = 120/486 (24%), Positives = 232/486 (47%), Gaps = 51/486 (10%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++ +K E +K K ++ + +A+ K +L++K +V+ +N L+ V+
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRK---ELEEKLVTLVQEKNDLQLQVQA------ 894
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSA--------LKSESTKLK 464
ESEN ++ ++ + K ++E K++ A E E++A L+ E ++LK
Sbjct: 895 --ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLK 524
KDI + + + +EK A EN+V L E++ L + +RE E +
Sbjct: 953 KDIDDLELTLAKVEKEK-------HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ 1005
Query: 525 AGISDTEKE---VNTLKKELVEKEKIVADSERKTAVDERKKAAAEARK-LLEAAKKIAPE 580
+ D + E VN+L K + E+ V D E +++ + E K LE K+A E
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 581 KAVIPEPANCCSKCDE-LKKKCEKVAVGRNALRQAVKI---LEKGIENLESENKKLKKEN 636
I + N + DE LKKK + ++ + + +K I+ L++ ++L E
Sbjct: 1066 S--ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL--EE 1121
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLK--AGISDTKKEVNRLKKEHVEEERIVADS 694
E+ A ++ + +++ ARE E L+ G++ T+ E+N KK E ++ D
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELN--KKREAEFLKLRRDL 1179
Query: 695 ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELS 754
E T E A L + AE+ +QI ++ + LEK+ +E K+++ +LS
Sbjct: 1180 EEATLQHE-----AMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID-DLS 1233
Query: 755 KTKEATKRFEAEKKKL--LVEKINAESKIKKAQ-ERSESELDKKTADMEKQQAEEQKKLA 811
+ E+ + +A +K+ +E +E++ K + +RS SEL + + ++ + E ++L
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLE 1293
Query: 812 EDKLLL 817
E + ++
Sbjct: 1294 EKESIV 1299
Score = 87.8 bits (216), Expect = 1e-16
Identities = 129/584 (22%), Positives = 258/584 (44%), Gaps = 82/584 (14%)
Query: 19 EELKKKCEQVVVGRNALRQAVKI----LEKGIENLESENKKLKKDIQE--------EQAQ 66
EE KKK Q + +AV LEK + L+ E + L D++ ++ Q
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447
Query: 67 R---KVAIEGKLEISNTFAALENEVSALISENKKLKQDILE-EQAQGKICDQLKKCEKVV 122
R KV E K + + A LE A + E++ L ++ + + A + DQL+ ++
Sbjct: 1448 RNFDKVLAEWKTKCEESQAELE----ASLKESRSLSTELFKLKNAYEEALDQLETVKR-- 1501
Query: 123 EGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVS 182
E +N LE+ I +L + + K I E + RK +IE LEK++ ALE +
Sbjct: 1502 ENKN--------LEQEIADLTEQIAENGKTIHELEKSRK-QIE--LEKADIQLALEEAEA 1550
Query: 183 ALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL---KQDILD 239
AL+ E K+ + LE + K EI A + E+ LK ++ Q LD
Sbjct: 1551 ALEHEEAKILRIQLE-------LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 240 EQAQGKF-CDRLKKKCEK-----VVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEH 293
+ + + RLKKK E ++ +A RQA + L K + +++ + K + + +
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL-KHLRSVQGQLKDTQLHLDDA- 1661
Query: 294 AQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFA 353
+ G+ ++ A +E + L++E ++L+ + + + RK+A + L+ +
Sbjct: 1662 ------LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Query: 354 ALENEVSALKSENKKLKQDILEEQAQ----GKFCDQLKKKCEKVVEGRNALRQAVKILEK 409
L + ++L KKL+ D+++ Q++ + ++K +K + + + +K +
Sbjct: 1716 LLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 410 GIENLESENKKLK---KDIQE--EQAQRKIEIEGKLEI---SNAFAALENEVSALKSEST 461
+LE K L+ KD+Q ++A++ GK +I LE E+ + ++T
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 462 KLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNG--- 518
+ K + + + ++K + E L++ V L+ ++ + +++ + N
Sbjct: 1836 ESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLT 1895
Query: 519 -------DVEVLKAGISDTEKEVNTLK---KELVEKEKIVADSE 552
++E + E +VN L+ ++ +V +SE
Sbjct: 1896 KFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
>MYHA_HUMAN (P35580) Myosin heavy chain, nonmuscle type B (Cellular
myosin heavy chain, type B) (Nonmuscle myosin heavy
chain-B) (NMMHC-B)
Length = 1976
Score = 135 bits (339), Expect = 6e-31
Identities = 189/874 (21%), Positives = 383/874 (43%), Gaps = 107/874 (12%)
Query: 12 ANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR---- 67
A +K +EL++ + + +IL+ + +++ + L++ + EE+ R
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 68 --KVAIEGKL-EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEG 124
KV E K+ ++ LE++ S I E KKL +D + E ++ ++ +K + + +
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKE-KKLMEDRIAE-CSSQLAEEEEKAKNLAKI 1028
Query: 125 RNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSAL 184
RN + LE+R++ E ++L E+A+RK++ E + + A L+ ++ L
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQEL------EKAKRKLDGE-TTDLQDQIAELQAQIDEL 1081
Query: 185 KSENKKLKKDI-----------LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL 233
K + K ++++ L + KV E + +I+ E+E A +++ +K
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQ 1140
Query: 234 KQDILDEQAQGKFCDRLKKKCEKVV-------EGRNALRQAVKILEKGIENLESENKKLK 286
K+D+ +E + LK + E + E R Q V L+K +E ++
Sbjct: 1141 KRDLSEE------LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 287 KDIQEEHAQRKVEIEGKLEISNAFAA-LENEVSALKSENKKLKKDILEEQAQRKVAMEGK 345
+D+++ HA E+ +LE + F A LE L+++NK+L ++ KV + K
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV-------KVLQQVK 1247
Query: 346 LEISNAFAALENEVSALK---SENKKLKQDILEEQAQ--------GKFCDQLKKKCEKVV 394
E + L+ +V L SE +L+ ++ E+ ++ ++ +KK K
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 395 EGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVS 454
+ +L ++ ++ ++ + L I++ + ++ E + E A LE +V
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 455 ALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSR 514
AL+S+ KK + ++ I+ E K ++ AL + E A K
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL----EEKALAYDKLEKTKN 1423
Query: 515 EGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERKKAAAEAR---- 568
+++ L + + + L+K+ + ++++A+ + +A +ER +A AEAR
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 569 ------KLLEAAKKIAPE-----KAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKI 617
+ LE A + E K + + + S D++ K ++ + AL Q V+
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 618 LEKGIENLE-----SENKKLKKENEVSALKSEISALQQKCGAGAREGN----GDVEVLKA 668
+ +E LE +E+ KL+ E + A+K++ Q E V L+A
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 669 GISDTKKE----VNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEV 724
+ D +K+ V KK ++ + + A E A R + RKL K E+
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIE--AANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 725 EKQIAKVELRQVHLEKQVNERKMK--------LAFELSKTKEATKRFEAEKKKLLVEKIN 776
E+ A+ ++ + + +E+K+K L EL+ ++ A + E E+ +L E N
Sbjct: 1662 EE--ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 777 AESKIKKAQERSESELDKKTADMEKQQAEEQKKL 810
+ S K A + L+ + A +E++ EEQ +
Sbjct: 1720 SASG-KSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Score = 134 bits (336), Expect = 1e-30
Identities = 199/877 (22%), Positives = 385/877 (43%), Gaps = 124/877 (14%)
Query: 12 ANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQE-EQAQRKVA 70
A C S+ E ++K + + RN +Q V I +LE KK +K QE E+A+RK+
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRN--KQEVMI-----SDLEERLKKEEKTRQELEKAKRKLD 1061
Query: 71 IEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQ 130
E ++ + A L+ ++ L KL+ EE+ QG + + ++ + NAL+
Sbjct: 1062 GE-TTDLQDQIAELQAQIDEL-----KLQLAKKEEELQGALA---RGDDETLHKNNALK- 1111
Query: 131 AVKILEKRI----ENLESEN------KKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENE 180
V+ L+ +I E+ ESE +K K+D+ EE K E+E L+ + A L +
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK 1171
Query: 181 VSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE 240
+ E +LKK + EE + ++ ++ A E+S + K+ K + L++
Sbjct: 1172 ---REQEVAELKKALEEETKNHEAQIQ---DMRQRHATALEELSEQLEQAKRFKAN-LEK 1224
Query: 241 QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEI 300
QG D + CE VK+L++ E + KKL +QE HA+
Sbjct: 1225 NKQGLETDNKELACE------------VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 301 EGKLEISNAFAALENE---VSAL--KSENKKLK---------------KDILEEQAQRKV 340
++E++ + L+NE VS L ++E K +K +++L+E+ ++K+
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332
Query: 341 AMEGKL---------------EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQ 385
+ ++ E A LE +V AL+S+ K+ + ++ + ++
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 386 LKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQ------EEQAQRKIEIEGK 439
KKK K E AL Q ++ + LE +L++++ + Q Q +E K
Sbjct: 1393 AKKKLLKDAE---ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 440 LEISNAFAALENEVSALKSESTKLKKDILEEQAQIKV--------AIEEKLEISNAFAAL 491
+ + A E +SA +E ++D E +A+ K A+EE LE F
Sbjct: 1450 QKKFDQLLAEEKSISARYAE----ERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505
Query: 492 ENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADS 551
++ A ++ + + G E +E K + +E+ T +EL ++ + D+
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHE----LEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 552 ERKTAVDERKKAAAEARKLLEAAKKIAPEK-AVIPEPANCCSKCDELKKKCEKVAVGRNA 610
+ + V+ + A R L ++ +K +I + ++ ++ +K+ +
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 611 LRQAVKILEKGIENL-ESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAG 669
+ +K LE IE ++ ++ +K+ ++ A + ++ A E + +
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 670 ISDTKKEVNRLKKEHVEEERI--VADSERKTAVDERKNAAAEARKLLEAPKKIAA----- 722
+ + E+ +L++E ER A+ ER DE N+A+ LL+ +++ A
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 723 --EVEKQIAKVELRQVHLEK---QVNERKMKLAFELS---KTKEATKRFEAEKKKLLVEK 774
E+E++ + +EL K QV+ +LA E S K+ A ++ E + K+L +
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801
Query: 775 INAESKIKKAQERSESELDKKTADMEKQQAEEQKKLA 811
E +K + + S L+ K +E+Q +E K+ A
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Score = 125 bits (313), Expect = 6e-28
Identities = 196/858 (22%), Positives = 387/858 (44%), Gaps = 138/858 (16%)
Query: 47 ENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQ 106
E L++++++L K ++E+Q + +EG+LE +E + L+ E L + + E
Sbjct: 852 EELQAKDEELLK-VKEKQTK----VEGELE------EMERKHQQLLEEKNILAEQLQAET 900
Query: 107 AQGKICDQLK-----KCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQ------- 154
++++ K +++ E + L V+ E+R + L++E KK++ IQ
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 155 -EEQAQRKIEIEGKLEKSNAFAALENEVSALKSEN------KKLKKDIL----------E 197
EE A++K+++E K+ +E E+ L+ +N KKL +D + E
Sbjct: 961 EEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 198 EQAQRKVAMEGKLEI------------SNAFAALENEVSALKSENKKLKQDILDEQAQGK 245
E+A+ + K E+ LE L E L+ I + QAQ
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ-- 1077
Query: 246 FCDRLK---KKCEKVVEGRNALRQAVKILEKG-----IENLESENKKLKKDIQEEHAQRK 297
D LK K E+ ++G A R + L K + L+++ +L++D + E A R
Sbjct: 1078 -IDELKLQLAKKEEELQGALA-RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135
Query: 298 VEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 357
+ K ++S E+ ALK+E L+ + AQ+++ + + E++ ALE
Sbjct: 1136 KAEKQKRDLS-------EELEALKTE---LEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 358 EVSALKSENKKLKQ-------DILEEQAQGK-FCDQLKKKCEKVVEGRNALRQAVKILEK 409
E +++ + ++Q ++ E+ Q K F L+K + + L VK+L++
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 410 GIENLESENKKLKKDIQEEQAQRKIEIEG---KLEISNAFAALENE---VSALKSESTK- 462
ESE+K+ K D Q ++ K+ EG ++E++ + L+NE VS L E+ K
Sbjct: 1246 --VKAESEHKRKKLDAQVQELHAKVS-EGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302
Query: 463 ----------LKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAG 512
L+ + + Q ++ +KL +S+ LE E ++L+ + Q++
Sbjct: 1303 GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ----QEEEEEA 1358
Query: 513 SREGNGDVEVLKAGISDTEKEVN----TLKKELVEKEKIVADSERKTAVDERKKAAAEAR 568
+ V L++ ++DT+K+V+ T++ K+K++ D+E A+ +R + A A
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEKALAY 1415
Query: 569 KLLEAAKKIAPEK-----AVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIE 623
LE K ++ + S ++ +KK +++ ++ A E+
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI-SARYAEERDRA 1474
Query: 624 NLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKE 683
E+ K+ K + AL+ + A +++ ++ D+E L + D K V+ L+K
Sbjct: 1475 EAEAREKETKALSLARALEEALEA-KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533
Query: 684 HVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVEL-RQVHLEKQV 742
E+ V E +T ++E ++ E + +A K+ EV Q K + R + +
Sbjct: 1534 KRALEQQV--EEMRTQLEELED---ELQATEDA--KLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 743 NERKMKLAFELSKTKEATKRFE--------AEKKKLLVEKINAESKIKKAQERSESELDK 794
NE K +L + + EA E A KKK+ ++ + E++I +A ++ E+ K
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIK 1645
Query: 795 KTADMEKQQAEEQKKLAE 812
+ ++ Q + Q++L E
Sbjct: 1646 QLRKLQAQMKDYQRELEE 1663
Score = 112 bits (281), Expect = 3e-24
Identities = 145/681 (21%), Positives = 313/681 (45%), Gaps = 72/681 (10%)
Query: 17 KCEELKKKCEQV-VVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
K +L+ + + V + A ++ +K K +LES+ + ++ +QEE Q KL
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFA-KDAASLESQLQDTQELLQEETRQ-------KL 1332
Query: 76 EISNTFAALENEVSALISEN-------KKLKQDILEEQAQ-----GKICDQLKKCEKVVE 123
+S+ LE E ++L + K L++ +L Q+Q K+ D L E + E
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 124 GRNALRQAVKILEKRIENLESENKKLKKD---IQEEQAQRKIEIEGKLEKSNAFAALENE 180
+ L + + L +R+E KL+K +Q+E ++++ + + ++ + +
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 181 VSALKSENKKLKKDILEEQAQRKV-AMEGKLEISNAFAALENEVSA---LKSENKKLKQD 236
L +E K + EE+ + + A E + + + ALE + A + +NK+L+ D
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 237 ILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENK-------KLKKDI 289
+ D + D + K ++ + + AL Q V+ + +E LE E + +L+ ++
Sbjct: 1513 MEDLMSSK---DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 290 QEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 349
Q AQ + +++ + E + E + L + ++L+ ++ +E+ QR +A+ K ++
Sbjct: 1570 QAMKAQFERDLQTRDEQN------EEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 350 NAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEK 409
LE ++ A ++ + + + QAQ K +++ E+ R+ + K EK
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMK---DYQRELEEARASRDEIFAQSKESEK 1680
Query: 410 GIENLESENKKLKKDI-QEEQAQRKIEIEGKL---EISNAFA---ALENEVSALKSESTK 462
+++LE+E +L++++ E+A+R E E EI+N+ + AL +E L++ +
Sbjct: 1681 KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ 1740
Query: 463 LKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAA---LQQKCGAGSREGNGD 519
L++++ EEQ+ +++ +++ F +V L +E+AA QK ++
Sbjct: 1741 LEEELEEEQSNMEL-------LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQ 1793
Query: 520 VEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAP 579
+ LKA + + E V + K + + + E K+ AA + + KK+
Sbjct: 1794 NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL-- 1851
Query: 580 EKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVS 639
K + + + D+ K++ EK L++ ++ E+ + +KL++E + +
Sbjct: 1852 -KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910
Query: 640 -----ALKSEISALQQKCGAG 655
L E+S L+ + G
Sbjct: 1911 TEANEGLSREVSTLKNRLRRG 1931
Score = 96.3 bits (238), Expect = 3e-19
Identities = 142/610 (23%), Positives = 274/610 (44%), Gaps = 93/610 (15%)
Query: 220 ENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLE 279
E E+ A E K+K+ + +G+ + +++K ++++E +N L + ++ E
Sbjct: 851 EEELQAKDEELLKVKEK--QTKVEGEL-EEMERKHQQLLEEKNILAEQLQA--------E 899
Query: 280 SENKKLKKDIQEEHAQRKVEIEGKL-EISNAFAALENEVSALKSENKKLKKDI--LEEQA 336
+E ++++ A +K E+E L ++ + E L++E KK++ I LEEQ
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 337 QRKVAMEGKLEISNAFAA-----LENEVSALKSENKK-LKQDILEEQAQGKFCDQLKKKC 390
+ KL++ A +E E+ L+ +N K +K+ L E + QL ++
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 391 EKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQE-EQAQRKIEIEGKLEISNAFAAL 449
EK + +R +++ I +LE KK +K QE E+A+RK++ E ++ + A L
Sbjct: 1020 EKA-KNLAKIRNKQEVM---ISDLEERLKKEEKTRQELEKAKRKLDGE-TTDLQDQIAEL 1074
Query: 450 ENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKC 509
+ ++ LK + K ++++ Q + +E L +NA V L+++IA LQ+
Sbjct: 1075 QAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKV----VRELQAQIAELQE-- 1125
Query: 510 GAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDE-----RKKAA 564
D E KA + EK+ L +EL + + D+ TA + R++
Sbjct: 1126 ---------DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 565 AEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIEN 624
AE +K LE K E + + +EL ++ E+ ++ LEK +
Sbjct: 1177 AELKKALEEETK-NHEAQIQDMRQRHATALEELSEQLEQA-------KRFKANLEKNKQG 1228
Query: 625 LESENKKLKKENEV-SALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKE 683
LE++NK+L E +V +K+E ++K A +E L A +S E +RL+ E
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE-------LHAKVS----EGDRLRVE 1277
Query: 684 HVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVN 743
E+ A++ + L+ + E EK+ K LE Q+
Sbjct: 1278 LAEK-------------------ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 744 ERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQ 803
+ + L E + + R + L E+ N+ + ++ +E + L+K+ ++ Q
Sbjct: 1319 DTQELLQEETRQKLNLSSRI-----RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 804 AEEQKKLAED 813
A+ +KK+ +D
Sbjct: 1374 ADTKKKVDDD 1383
Score = 64.7 bits (156), Expect = 1e-09
Identities = 65/332 (19%), Positives = 152/332 (45%), Gaps = 56/332 (16%)
Query: 7 VIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 66
VI + ++ ++ +++ E+ R+ + K EK +++LE+E +L++++ +
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 67 RKVAIEGKLEISNTFAALENEVSALISENKK-------LKQDILEEQAQGKIC-DQLKKC 118
R+ A + + E+++ + SAL+ E ++ L++++ EEQ+ ++ D+ +K
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 119 EKVVEGRNALRQAVKILEKRIEN----LESENKKLKKDIQEEQAQRKIEIEGKLEKSNAF 174
V+ NA A + ++ +N LE +NK+LK +QE + K + + +
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI------ 1816
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
+ALE ++ L+ + LE++A+ + A ++ KKLK
Sbjct: 1817 SALEAKIGQLEEQ--------LEQEAKERAAAN----------------KLVRRTEKKLK 1852
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHA 294
+ + + + + D+ K++ EK L++ ++ E+ + +KL++++
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD---- 1908
Query: 295 QRKVEIEGKLEISNAFAALENEVSALKSENKK 326
+ + A L EVS LK+ ++
Sbjct: 1909 ----------DATEANEGLSREVSTLKNRLRR 1930
Score = 58.2 bits (139), Expect = 9e-08
Identities = 102/485 (21%), Positives = 209/485 (43%), Gaps = 80/485 (16%)
Query: 354 ALENEVSALKSENKKLKQDIL--EEQAQGKFCDQL---KKKCEKVVEGRNALRQAVKILE 408
+L ++ L++ N + I+ E+ GK L + +C V+EG ++I
Sbjct: 660 SLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEG-------IRICR 712
Query: 409 KGIEN-LESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKL--KK 465
+G N + + + + +I A K ++GK ALE + + + +K+ +
Sbjct: 713 QGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRA 772
Query: 466 DIL---EEQAQIKV--------AIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSR 514
+L EE+ +K+ A+ AFA + ++SALK LQ+ C A +
Sbjct: 773 GVLAHLEEERDLKITDIIIFFQAVCRGCLARKAFAKKQQQLSALK----VLQRNCAAYLK 828
Query: 515 EGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK-KAAAEARKLLEA 573
+ + +V L + ++E++ A E V E++ K E ++
Sbjct: 829 LRHWQWWRVFT-------KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK 881
Query: 574 AKKIAPEKAVIPEPANCCSKC-DELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL 632
+++ EK ++ E ++ E ++ ++A + L + + LE +E E N+ L
Sbjct: 882 HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
+NE +++ I L+++ E G + L+ +K K + +EEE ++
Sbjct: 942 --QNEKKKMQAHIQDLEEQLD----EEEGARQKLQL-----EKVTAEAKIKKMEEEILLL 990
Query: 693 DSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFE 752
+ + + E+K L+E AE Q+A+ E + +L K N++++ ++
Sbjct: 991 EDQNSKFIKEKK--------LMEDR---IAECSSQLAEEEEKAKNLAKIRNKQEVMISD- 1038
Query: 753 LSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAE 812
L E++ E K ++ E+++ +LD +T D++ Q AE Q ++ E
Sbjct: 1039 ------------------LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 813 DKLLL 817
KL L
Sbjct: 1081 LKLQL 1085
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/202 (22%), Positives = 94/202 (45%), Gaps = 31/202 (15%)
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
KK+ ++SALK LQ+ C A + + + + + + ++ ++E ++
Sbjct: 808 KKQQQLSALK----VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLK 863
Query: 693 DSERKTAVD--------------ERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHL 738
E++T V+ E KN AE L+A ++ AE E+ A++ ++ L
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQ---LQAETELFAEAEEMRARLAAKKQEL 920
Query: 739 EKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTAD 798
E+ +++ + ++ E +E + + EKKK+ + E ++ E E ++
Sbjct: 921 EEILHDLESRVEEE----EERNQILQNEKKKMQAHIQDLEEQL------DEEEGARQKLQ 970
Query: 799 MEKQQAEEQKKLAEDKLLLLGD 820
+EK AE + K E+++LLL D
Sbjct: 971 LEKVTAEAKIKKMEEEILLLED 992
>MYH3_RAT (P12847) Myosin heavy chain, fast skeletal muscle, embryonic
Length = 1940
Score = 134 bits (338), Expect = 7e-31
Identities = 174/832 (20%), Positives = 361/832 (42%), Gaps = 86/832 (10%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E L + I + ++K E +
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETIAKLTREKKALQEAHQQ 1006
Query: 77 ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVE-GRNALRQAVKIL 135
+ A E++V++L KL+Q + + ++ +Q KK +E + L +K+
Sbjct: 1007 TLDDLQAEEDKVNSLSKLKSKLEQQVDDLESS---LEQEKKLRVDLERNKRKLEGDLKLA 1063
Query: 136 EKRIENLESENKKL-----KKDIQEEQAQRKIEIEGKL---------EKSNAFAALENEV 181
++ I +LE++ ++L KKD + Q Q K+E E L E LE E+
Sbjct: 1064 QESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQARIEELEEEI 1123
Query: 182 SALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK-SENKKLKQDILDE 240
A ++ K +K + A+ + +LE + + + E++ + +E KL++D+ +
Sbjct: 1124 EAERATRAKTEKQ-RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182
Query: 241 QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEI 300
Q + +K K + L + + L++ + LE E + K +I + + +
Sbjct: 1183 TLQHEATVATLRK--KHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVS 1240
Query: 301 EGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVS 360
+ K + LE+++S + +N++ ++ + E Q+ E+S E+ VS
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 361 ALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKK 420
L + Q I ++LK++ E+ + +NAL A +++ +
Sbjct: 1301 QLSRSKQAFTQQI----------EELKRQLEEENKAKNALAHA-------LQSSRHDCDL 1343
Query: 421 LKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEE 480
L++ +EEQ EGK E+ A + +EV+ + TK + D ++ +++ E
Sbjct: 1344 LREQYEEEQ-------EGKAELQRALSKANSEVAQWR---TKYETDAIQRTEELE---EA 1390
Query: 481 KLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKE 540
K +++ E +V A+ ++ A+L++ + G+VE L + L K+
Sbjct: 1391 KKKLAQRLQDSEEQVEAVNAKCASLEKT----KQRLQGEVEDLMVDVERANSLAAALDKK 1446
Query: 541 LVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKK 600
+K++A E K E++ LEAA K +++ E + +E +
Sbjct: 1447 QRNFDKVLA---------EWKTKCEESQAELEAALK--ESRSLSTELFKLKNAYEEALDQ 1495
Query: 601 CEKVAVGRNALRQAVKILEKGI-ENLESENKKLKKENEVSALKSEISALQQKCGAGAREG 659
E V L Q + L + I EN +S ++ K ++ K++I ++ A
Sbjct: 1496 LETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHE 1555
Query: 660 NGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKK 719
+ ++ ++ K E++R E EE + + ++T + AE R EA +
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEA-IR 1614
Query: 720 IAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTK-------EATKRFEAEKKKLLV 772
+ ++E + ++E++ H +Q E L + K +A + E K++L +
Sbjct: 1615 LKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAI 1674
Query: 773 EKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQL 824
+++ ++E+++ A +E Q E +KLAE +LL + +QL
Sbjct: 1675 --------VERRANLLQAEVEELRATLE--QTERARKLAEQELLDSNERVQL 1716
Score = 132 bits (332), Expect = 4e-30
Identities = 199/901 (22%), Positives = 395/901 (43%), Gaps = 120/901 (13%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKL-----KKDIQEEQAQRKVA 70
S E+ KK + + L +K+ ++ I +LE++ ++L KKD + Q Q KV
Sbjct: 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVE 1096
Query: 71 IEGKLEISNTFAALENEVSALISENKKLKQDILEEQA-----QGKICDQLKKCEKVVEGR 125
E L + L+ ++ L + ++L+++I E+A + + D ++ E++ E
Sbjct: 1097 DEQTLSLQ-----LQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE-- 1149
Query: 126 NALRQAVKILEKRIE---NLESENKKLKKDIQEEQAQ--------RKIEIEGKLEKSNAF 174
L +A + +IE E+E KL++D++E Q RK + E +
Sbjct: 1150 -RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQI 1208
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
L+ L+ E + K +I + + + + K + LE+++S + +N++ +
Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQ 1268
Query: 235 QDILDEQAQ--------GKFCDRLKKKCEKVVEGRNALRQA-VKILEKGIENLESENK-- 283
+ + + Q G+ +L++K E +V + +QA + +E+ LE ENK
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEK-ESIVSQLSRSKQAFTQQIEELKRQLEEENKAK 1327
Query: 284 --------KLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSA--LKSENKKLKKDILE 333
+ D Q + E EGK E+ A + +EV+ K E +++
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1387
Query: 334 EQAQRKVAM-----EGKLEISNA-FAALENEVSALKSENKKLKQDILEEQAQGKFCDQLK 387
E+A++K+A E ++E NA A+LE L+ E + L D+ + D+ +
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447
Query: 388 KKCEKVV-EGRNALRQAVKILEKGIE---NLESENKKLKKDIQEEQAQRKIEIEGKLEIS 443
+ +KV+ E + ++ LE ++ +L +E KLK +E Q + +
Sbjct: 1448 RNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507
Query: 444 NAFAALENEVSALKS---ESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENE---VSA 497
A L +++ E K +K + E+A I++A+EE A AALE+E +
Sbjct: 1508 QEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEE------AEAALEHEEAKILR 1561
Query: 498 LKSEIAALQQKCGAGSREGNGDVEVLKAGISDT--------EKEVNTLKKELVEKEKIVA 549
++ E+ ++ + E + ++E LK T + EV + + + K+K+
Sbjct: 1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEG 1621
Query: 550 D-SERKTAVDERKKAAAEARKLLEAAK------------------KIAPEKAVIPEPANC 590
D +E + + + AAE K L + + + + A++ AN
Sbjct: 1622 DLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 1681
Query: 591 C-SKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQ 649
++ +EL+ E+ R Q + + ++ L ++N L + L+++++ LQ
Sbjct: 1682 LQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK--KLETDLTQLQ 1739
Query: 650 QKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEH---VEEERIVADSERKTAVDERKNA 706
+ +R+ E K I+D LKKE ER+ + E+ V + ++
Sbjct: 1740 SEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ--TVKDLQHR 1797
Query: 707 AAEARKL-LEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEA 765
EA +L L+ KK ++E +I ++E +K+ E L + KE T + E
Sbjct: 1798 LDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSEE 1857
Query: 766 EKKKL-----LVEKINAESK-----IKKAQERSESELDK-KTADMEKQQAEEQKKLAEDK 814
++K + LV+K+ + K ++A E++ L K + A E ++AEE+ +AE +
Sbjct: 1858 DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANVHLTKFRKAQHELEEAEERADIAESQ 1917
Query: 815 L 815
+
Sbjct: 1918 V 1918
Score = 94.7 bits (234), Expect = 9e-19
Identities = 121/486 (24%), Positives = 233/486 (47%), Gaps = 51/486 (10%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++ +K E +K K ++ + +A+ K +L++K +V+ +N L+ V+
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRK---ELEEKLVTLVQEKNDLQLQVQA------ 894
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSA--------LKSESTKLK 464
ESEN ++ ++ + K ++E K++ A E E++A L+ E ++LK
Sbjct: 895 --ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLK 524
KDI + + + +EK A EN+V L E+A L + +RE E +
Sbjct: 953 KDIDDLELTLAKVEKEK-------HATENKVKNLTEELAGLDETIAKLTREKKALQEAHQ 1005
Query: 525 AGISDTEKE---VNTLKKELVEKEKIVADSERKTAVDERKKAAAEARK-LLEAAKKIAPE 580
+ D + E VN+L K + E+ V D E +++ + E K LE K+A E
Sbjct: 1006 QTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 581 KAVIPEPANCCSKCDE-LKKKCEKVAVGRNALRQAVKI---LEKGIENLESENKKLKKEN 636
I + N + DE LKKK + + ++ + + L+K I+ L++ ++L E
Sbjct: 1066 S--ILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQARIEEL--EE 1121
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLK--AGISDTKKEVNRLKKEHVEEERIVADS 694
E+ A ++ + +++ ARE E L+ G++ T+ E+N KK E ++ D
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELN--KKREAEFLKLRRDL 1179
Query: 695 ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELS 754
E T E A L + AAE+ +QI ++ + LEK+ +E K+++ +LS
Sbjct: 1180 EEATLQHE-----ATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEID-DLS 1233
Query: 755 KTKEATKRFEAEKKKL---LVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLA 811
+ E+ + +A +K+ L ++++ + +RS SEL + + ++ + E ++L
Sbjct: 1234 SSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKSRLQTEAGELSRQLE 1293
Query: 812 EDKLLL 817
E + ++
Sbjct: 1294 EKESIV 1299
Score = 85.1 bits (209), Expect = 7e-16
Identities = 126/584 (21%), Positives = 255/584 (43%), Gaps = 82/584 (14%)
Query: 19 EELKKKCEQVVVGRNALRQAVKI----LEKGIENLESENKKLKKDIQE--------EQAQ 66
EE KKK Q + +AV LEK + L+ E + L D++ ++ Q
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447
Query: 67 R---KVAIEGKLEISNTFAALENEVSALISENKKLKQDILE-EQAQGKICDQLKKCEKVV 122
R KV E K + + A LE A + E++ L ++ + + A + DQL+ ++
Sbjct: 1448 RNFDKVLAEWKTKCEESQAELE----AALKESRSLSTELFKLKNAYEEALDQLETVKR-- 1501
Query: 123 EGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVS 182
E +N LE+ I +L + + K I E + RK + +LEK++ ALE +
Sbjct: 1502 ENKN--------LEQEIADLTEQIAENGKSIHELEKSRK---QMELEKADIQMALEEAEA 1550
Query: 183 ALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL---KQDILD 239
AL+ E K+ + LE + K EI A + E+ LK ++ Q LD
Sbjct: 1551 ALEHEEAKILRIQLE-------LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALD 1603
Query: 240 EQAQGKF-CDRLKKKCEK-----VVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEH 293
+ + + RLKKK E ++ +A RQA + + K + +++ + K + + +
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETI-KHLRSVQGQLKDTQLHLDDA- 1661
Query: 294 AQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFA 353
+ G+ ++ A +E + L++E ++L+ + + + RK+A + L+ +
Sbjct: 1662 ------LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Query: 354 ALENEVSALKSENKKLKQDILEEQAQ----GKFCDQLKKKCEKVVEGRNALRQAVKILEK 409
L + ++L KKL+ D+ + Q++ + ++K +K + + + +K +
Sbjct: 1716 LLHTQNTSLIHTKKKLETDLTQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 410 GIENLESENKKLK---KDIQE--EQAQRKIEIEGKLEI---SNAFAALENEVSALKSEST 461
+LE K L+ KD+Q ++A++ GK +I LE E+ + +T
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNT 1835
Query: 462 KLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGN---- 517
+ K + + + ++K + E L++ V L+ ++ + +++ + N
Sbjct: 1836 ESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANVHLT 1895
Query: 518 ------GDVEVLKAGISDTEKEVNTLK---KELVEKEKIVADSE 552
++E + E +VN L+ ++ +V +SE
Sbjct: 1896 KFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
>MYSC_CHICK (P29616) Myosin heavy chain, cardiac muscle isoform
(Fragment)
Length = 1102
Score = 134 bits (337), Expect = 1e-30
Identities = 167/818 (20%), Positives = 365/818 (44%), Gaps = 99/818 (12%)
Query: 43 EKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDI 102
EK + N++ E KLK+ +++ +A+RK LE + +L+ E L +
Sbjct: 12 EKEMANMKEEFLKLKEALEKSEARRK--------------ELEEKQVSLVQEKNDL---L 54
Query: 103 LEEQA-QGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKL---KKDIQEEQA 158
L+ QA Q + D ++C+ +++ + L VK L +R+E+ E N +L K+ +++E +
Sbjct: 55 LQLQAEQDTLADAEERCDLLIKSKIQLEAKVKELTERVEDEEEMNSELTSKKRKLEDECS 114
Query: 159 QRKIEIE------GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEI 212
+ K +I+ K+EK A EN+V L E L ++I + ++K E ++
Sbjct: 115 ELKKDIDDLEITLAKVEKEK--HATENKVKNLTEEMATLDENISKLTKEKKSLQEAHQQV 172
Query: 213 SNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILE 272
+ A E++V+ L KL+Q + D + ++ KK + + L +K+ +
Sbjct: 173 LDDLQAEEDKVNTLSKAKVKLEQQVDDLEGS---LEQEKKVRMDLERAKRKLEGDLKLTQ 229
Query: 273 KGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA-ALENEVSALKSENKKLKKDI 331
+ + +LE++ ++++ ++++ + ++ K+E A L+ ++ L++ ++L++++
Sbjct: 230 ESVMDLENDKLQMEEKLKKKEFEMS-QLNSKIEDEQAIVMQLQKKIKELQARIEELEEEL 288
Query: 332 LEEQAQRKVAMEGKLEISNAFAALENEV-------SALKSENKKLKQDILE-----EQAQ 379
E+A R + + +++ L + +A NKK + + L+ E+A
Sbjct: 289 EAERAARAKVEKQRSDLARELEELSERLEGAGGATAAQLEMNKKREAEFLKLARDLEEAT 348
Query: 380 GKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGK 439
+ +K + R + + + L++ + LE E +LK ++ + A + ++GK
Sbjct: 349 LHYEATAAALRKKHADRRGEMGEQLDNLQRVKQKLEKEKSELKMEVDDLTANMEQTVKGK 408
Query: 440 LEISNAFAALE---NEVSALKSESTKLKKDILEEQAQIKVA----IEEKLEISNAFAALE 492
+ E NE E T+L D+ ++ +++ + + E + + L
Sbjct: 409 ANAEKLWGTYEDHLNETKTKLDEMTRLMNDLTTQKTKLQSENGEFVRQLEEKESLISQLS 468
Query: 493 NEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSE 552
++ +I L+++ ++ N L+A D + L+++ E+++ A+ +
Sbjct: 469 RGKTSFTQQIEELRRQLEEETKSKNALAHALQAARHDCD----LLREQYEEEQEAKAELQ 524
Query: 553 R----------------KTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCS---K 593
R +T +R + +A+K L A + A E+A+ A C S
Sbjct: 525 RALSKGNAEVAQWRTKYETDAIQRTEELEDAKKKLLARLQEA-EEAIEAANAKCSSLEKA 583
Query: 594 CDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCG 653
L+ + E + + A L+K + K++ E S ++E+ A Q++
Sbjct: 584 KHRLQNEQEDMMIDLEKANSAAASLDKKQRGFDKIINDWKQKYEES--QAELEASQKE-- 639
Query: 654 AGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKL 713
AR + ++ LK +T + LK+E+ + ++D N +E K
Sbjct: 640 --ARSLSTELFKLKNAYEETLDHLETLKRENKNLQEEISD---------LTNQISEGNKN 688
Query: 714 LEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMK-LAFELSKTKEATKRFEAEKKKLLV 772
L +K+ +VE++ ++V+L E + + K L F+L + +A+ ++ L
Sbjct: 689 LHEIEKVKKQVEQEKSEVQLALEEAEGALEHEESKTLRFQLE-----LSQLKADFERKLA 743
Query: 773 EKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKL 810
EK I++ Q+R+ L + T D E + E +L
Sbjct: 744 EKDEEMQNIRRNQQRTIDSL-QSTLDSEARSRNEAIRL 780
Score = 122 bits (307), Expect = 3e-27
Identities = 185/887 (20%), Positives = 373/887 (41%), Gaps = 99/887 (11%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E L ++I + ++K E +
Sbjct: 112 ECSELKKDIDDLEITLAKVEKEKHATENKVKNLTEEMATLDENISKLTKEKKSLQEAHQQ 171
Query: 77 ISNTFAALENEVSALISENKKLKQ--DILEE--QAQGKICDQLKKCEKVVEGRNALRQAV 132
+ + A E++V+ L KL+Q D LE + + K+ L++ ++ +EG L Q
Sbjct: 172 VLDDLQAEEDKVNTLSKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE- 230
Query: 133 KILEKRIENLESENKKLKKDIQEEQAQRKIE--------IEGKLEKSNA-FAALENEVSA 183
+++ + L+ E K KK+ + Q KIE ++ K+++ A LE E+ A
Sbjct: 231 SVMDLENDKLQMEEKLKKKEFEMSQLNSKIEDEQAIVMQLQKKIKELQARIEELEEELEA 290
Query: 184 LKSENKKLKK---DILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE 240
++ K++K D+ E + +EG A AA ++E KL +D+ E
Sbjct: 291 ERAARAKVEKQRSDLARELEELSERLEG---AGGATAAQLEMNKKREAEFLKLARDL--E 345
Query: 241 QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEI 300
+A + +K + R + + + L++ + LE E +LK ++ + A + +
Sbjct: 346 EATLHYEATAAALRKKHADRRGEMGEQLDNLQRVKQKLEKEKSELKMEVDDLTANMEQTV 405
Query: 301 EGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVS 360
+GK + E+ ++ K++ ++ + + + Q+ E E+ +S
Sbjct: 406 KGKANAEKLWGTYEDHLNETKTKLDEMTRLMNDLTTQKTKLQSENGEFVRQLEEKESLIS 465
Query: 361 ALKSENKKLKQDI------LEEQAQGK------------FCDQLKKKCEKVVEGRNALRQ 402
L Q I LEE+ + K CD L+++ E+ E + L++
Sbjct: 466 QLSRGKTSFTQQIEELRRQLEEETKSKNALAHALQAARHDCDLLREQYEEEQEAKAELQR 525
Query: 403 AVKILEKGIENLESENKKLKKDI-----QEEQAQRKI-----EIEGKLEISNA-FAALEN 451
A L KG + K + D + E A++K+ E E +E +NA ++LE
Sbjct: 526 A---LSKGNAEVAQWRTKYETDAIQRTEELEDAKKKLLARLQEAEEAIEAANAKCSSLEK 582
Query: 452 EVSALKSESTKLKKDILEEQAQIKVAI---------------EEKLEISNA-FAALENEV 495
L++E + D+ E+A A ++K E S A A + E
Sbjct: 583 AKHRLQNEQEDMMIDL--EKANSAAASLDKKQRGFDKIINDWKQKYEESQAELEASQKEA 640
Query: 496 SALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSER-K 554
+L +E+ L+ E +E LK + ++E++ L ++ E K + + E+ K
Sbjct: 641 RSLSTELFKLKN----AYEETLDHLETLKRENKNLQEEISDLTNQISEGNKNLHEIEKVK 696
Query: 555 TAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQA 614
V++ K A + E A + K + + K D +K EK +N R
Sbjct: 697 KQVEQEKSEVQLALEEAEGALEHEESKTLRFQLELSQLKADFERKLAEKDEEMQNIRRNQ 756
Query: 615 VKILEKGIENLESENK--------KLKKENEVSALKSEISALQQKCGAGAREGNGDVEVL 666
+ ++ L+SE + K K E +++ ++ ++S + + G L
Sbjct: 757 QRTIDSLQSTLDSEARSRNEAIRLKKKMEGDLNEMEIQLSHANRHAAEATKSARG----L 812
Query: 667 KAGISDTKKEVNRL--KKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEV 724
+ I + + +++ L E ++E+ V+D E A + A K E+
Sbjct: 813 QTQIKELQVQLDDLGHLNEDLKEQLAVSDRRNNLLQSELDELRALLDQTERARKLAEHEL 872
Query: 725 EKQIAKVELRQVHLEKQVNERK------MKLAFELSKTKEATKRFEAEKKKLLVEKINAE 778
+ +V L +N++K ++ E+ ++ + + E + KK + +
Sbjct: 873 LEATERVNLLHTQNTSLINQKKKLEGDISQMQNEVEESIQECRNAEQKAKKAITDAAMMA 932
Query: 779 SKIKKAQERSESELDKKTADMEKQQAEEQKKLAE-DKLLLLGDSLQL 824
++KK Q+ S + L++ +ME+ + QK+L E +++ L G Q+
Sbjct: 933 EELKKEQDTS-AHLERMKKNMEQTIKDLQKRLDEAEQIALKGGKKQI 978
Score = 115 bits (289), Expect = 4e-25
Identities = 158/671 (23%), Positives = 303/671 (44%), Gaps = 89/671 (13%)
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
A E E++ +K E KLK+ + + +A+RK +LE E +VS ++ +N L
Sbjct: 9 AETEKEMANMKEEFLKLKEALEKSEARRK-----ELE--------EKQVSLVQEKNDLL- 54
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL---KKDIQE 291
L QA+ +++C+ +++ + L VK L + +E+ E N +L K+ +++
Sbjct: 55 ---LQLQAEQDTLADAEERCDLLIKSKIQLEAKVKELTERVEDEEEMNSELTSKKRKLED 111
Query: 292 EHAQRKVEIEGKLEISNAFA-----ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKL 346
E ++ K +I+ LEI+ A A EN+V L E L ++I + ++K E
Sbjct: 112 ECSELKKDID-DLEITLAKVEKEKHATENKVKNLTEEMATLDENISKLTKEKKSLQEAHQ 170
Query: 347 EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKI 406
++ + A E++V+ L KL+Q + + +G +Q KK + + L +K+
Sbjct: 171 QVLDDLQAEEDKVNTLSKAKVKLEQQV--DDLEGSL-EQEKKVRMDLERAKRKLEGDLKL 227
Query: 407 LEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKD 466
++ + +L EN KL+ EE+ ++K + E+S + +E+E + + +L+K
Sbjct: 228 TQESVMDL--ENDKLQ---MEEKLKKK-----EFEMSQLNSKIEDEQAIV----MQLQKK 273
Query: 467 ILEEQAQIKVAIEEKLEISNAF-AALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKA 525
I E QA+I+ +EE+LE A A +E + S L E+ L ++ +E+ K
Sbjct: 274 IKELQARIE-ELEEELEAERAARAKVEKQRSDLARELEELSERLEGAGGATAAQLEMNKK 332
Query: 526 GISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIP 585
++ K L++ + E A + RK D R + + L +K+ EK+ +
Sbjct: 333 REAEFLKLARDLEEATLHYEATAA-ALRKKHADRRGEMGEQLDNLQRVKQKLEKEKSELK 391
Query: 586 EPANCCSKCDELKKKCEKVAVGR--------------NALRQAVKILEKGIENLESENKK 631
+ D+L E+ G+ N + + + + + +L ++ K
Sbjct: 392 ------MEVDDLTANMEQTVKGKANAEKLWGTYEDHLNETKTKLDEMTRLMNDLTTQKTK 445
Query: 632 LKKEN-EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERI 690
L+ EN E E +L + G +E L+ + + K N L ++ R
Sbjct: 446 LQSENGEFVRQLEEKESLISQLSRGKTSFTQQIEELRRQLEEETKSKNAL-AHALQAARH 504
Query: 691 VADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLA 750
D R+ +E + A AE ++ L K AEV + K E + +++ + K KL
Sbjct: 505 DCDLLRE-QYEEEQEAKAELQRAL---SKGNAEVAQWRTKYETDAIQRTEELEDAKKKLL 560
Query: 751 FELSKTKEATKRFEAEKKKLLVEKINAE-SKIKKAQERSESELDKKTADMEKQQAE---- 805
L + +EA +E NA+ S ++KA+ R ++E + D+EK +
Sbjct: 561 ARLQEAEEA------------IEAANAKCSSLEKAKHRLQNEQEDMMIDLEKANSAAASL 608
Query: 806 EQKKLAEDKLL 816
++K+ DK++
Sbjct: 609 DKKQRGFDKII 619
Score = 84.0 bits (206), Expect = 2e-15
Identities = 123/517 (23%), Positives = 233/517 (44%), Gaps = 71/517 (13%)
Query: 311 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 370
A E E++ +K E KLK+ + + +A+RK +LE E +VS ++ +N L
Sbjct: 9 AETEKEMANMKEEFLKLKEALEKSEARRK-----ELE--------EKQVSLVQEKNDLL- 54
Query: 371 QDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQA 430
L+ QA+ +++C+ +++ + L VK L + +E+ E N +L
Sbjct: 55 ---LQLQAEQDTLADAEERCDLLIKSKIQLEAKVKELTERVEDEEEMNSELTSK------ 105
Query: 431 QRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAA 490
+RK+E E ++LKKDI + +I +A EK + A
Sbjct: 106 KRKLE----------------------DECSELKKDI--DDLEITLAKVEKEK-----HA 136
Query: 491 LENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKE---VNTLKKELVEKEKI 547
EN+V L E+A L + ++E E + + D + E VNTL K V+ E+
Sbjct: 137 TENKVKNLTEEMATLDENISKLTKEKKSLQEAHQQVLDDLQAEEDKVNTLSKAKVKLEQQ 196
Query: 548 VADSERKTAVDERKKAAAE-ARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAV 606
V D E +++ + E A++ LE K+ E + E + ++LKKK +++
Sbjct: 197 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESVMDLENDKLQME-EKLKKKEFEMSQ 255
Query: 607 GRNALRQAVKI---LEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDV 663
+ + I L+K I+ L++ ++L E E+ A ++ + ++++ ARE
Sbjct: 256 LNSKIEDEQAIVMQLQKKIKELQARIEEL--EEELEAERAARAKVEKQRSDLARELEELS 313
Query: 664 EVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAE 723
E L+ T ++ KK E ++ D E T E A A A + A ++ E
Sbjct: 314 ERLEGAGGATAAQLEMNKKREAEFLKLARDLEEATLHYE---ATAAALRKKHADRR--GE 368
Query: 724 VEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL---LVEKINAESK 780
+ +Q+ ++ + LEK+ +E KM++ +L+ E T + +A +KL + +N
Sbjct: 369 MGEQLDNLQRVKQKLEKEKSELKMEVD-DLTANMEQTVKGKANAEKLWGTYEDHLNETKT 427
Query: 781 IKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLL 817
R ++L + ++ + E ++L E + L+
Sbjct: 428 KLDEMTRLMNDLTTQKTKLQSENGEFVRQLEEKESLI 464
Score = 50.4 bits (119), Expect = 2e-05
Identities = 44/230 (19%), Positives = 115/230 (49%), Gaps = 12/230 (5%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
++ +EL+ + + + L++ + + ++ L+SE +L+ + + + RK+A L
Sbjct: 814 TQIKELQVQLDDLGHLNEDLKEQLAVSDRRNNLLQSELDELRALLDQTERARKLAEHELL 873
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVE-GRNALRQAVKI 134
E + L + ++LI++ KKL+ DI Q Q ++ + +++C + + A+ A +
Sbjct: 874 EATERVNLLHTQNTSLINQKKKLEGDI--SQMQNEVEESIQECRNAEQKAKKAITDAAMM 931
Query: 135 LE--KRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAAL--ENEVSALKSENKK 190
E K+ ++ + +++KK+++ Q +++ +L+++ A + ++ L+S ++
Sbjct: 932 AEELKKEQDTSAHLERMKKNME----QTIKDLQKRLDEAEQIALKGGKKQIQKLESRVRE 987
Query: 191 LKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDE 240
L+ ++ E + A +G + L + S +N QD++D+
Sbjct: 988 LENELENELRRNSDAQKGARKFERRIKELTYQ-SEEDKKNLARMQDLIDK 1036
Score = 47.4 bits (111), Expect = 2e-04
Identities = 75/404 (18%), Positives = 166/404 (40%), Gaps = 60/404 (14%)
Query: 20 ELKKKCEQVVVGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEQAQRKVAIE 72
E++K +QV ++ ++ A++ E +E+ ES E +LK D + + A++ ++
Sbjct: 691 EIEKVKKQVEQEKSEVQLALEEAEGALEHEESKTLRFQLELSQLKADFERKLAEKDEEMQ 750
Query: 73 G-----KLEISNTFAALENEVSA---LISENKKLKQDILEEQAQGKICD----------- 113
+ I + + L++E + I KK++ D+ E + Q +
Sbjct: 751 NIRRNQQRTIDSLQSTLDSEARSRNEAIRLKKKMEGDLNEMEIQLSHANRHAAEATKSAR 810
Query: 114 ----QLKKCEKVVEGRNALRQAVK----ILEKRIENLESENKKLKKDIQEEQAQRKIEIE 165
Q+K+ + ++ L + +K + ++R L+SE +L+ + + + RK+
Sbjct: 811 GLQTQIKELQVQLDDLGHLNEDLKEQLAVSDRRNNLLQSELDELRALLDQTERARKLAEH 870
Query: 166 GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSA 225
LE + L + ++L ++ KKL+ DI + Q + + +++ E NA E +
Sbjct: 871 ELLEATERVNLLHTQNTSLINQKKKLEGDISQMQNEVEESIQ---ECRNA----EQKAKK 923
Query: 226 LKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNA-------------------LRQ 266
++ + +++ EQ +R+KK E+ ++ L
Sbjct: 924 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQKRLDEAEQIALKGGKKQIQKLES 983
Query: 267 AVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKK 326
V+ LE +EN N +K ++ + K E A +++ + L+ + K
Sbjct: 984 RVRELENELENELRRNSDAQKGARKFERRIKELTYQSEEDKKNLARMQDLIDKLQLKVKS 1043
Query: 327 LKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 370
K E +AQ + + + + E +S+ KL+
Sbjct: 1044 YKHQAEEAEAQANLYLSKYRKQQHDLDDAEERAEIAESQVDKLR 1087
Score = 35.8 bits (81), Expect = 0.47
Identities = 50/220 (22%), Positives = 99/220 (44%), Gaps = 21/220 (9%)
Query: 37 QAVKILEKGIENLESENKKLKKDIQEEQAQRKVAI------EGKLEISNTFAAL------ 84
+ V +L +L ++ KKL+ DI + Q + + +I E K + + T AA+
Sbjct: 877 ERVNLLHTQNTSLINQKKKLEGDISQMQNEVEESIQECRNAEQKAKKAITDAAMMAEELK 936
Query: 85 -ENEVSALISENKK-LKQDILEEQAQGKICDQ--LKKCEKVVEGRNALRQAVKILEKRIE 140
E + SA + KK ++Q I + Q + +Q LK +K ++ L V+ LE +E
Sbjct: 937 KEQDTSAHLERMKKNMEQTIKDLQKRLDEAEQIALKGGKKQIQ---KLESRVRELENELE 993
Query: 141 NLESENKKLKKDIQE-EQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQ 199
N N +K ++ E+ +++ + + +K N A +++ + L+ + K K E +
Sbjct: 994 NELRRNSDAQKGARKFERRIKELTYQSEEDKKN-LARMQDLIDKLQLKVKSYKHQAEEAE 1052
Query: 200 AQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILD 239
AQ + + + + E +S+ KL+ D
Sbjct: 1053 AQANLYLSKYRKQQHDLDDAEERAEIAESQVDKLRSKSRD 1092
>MYHD_HUMAN (Q9UKX3) Myosin heavy chain, skeletal muscle, extraocular
(MyHC-eo)
Length = 1938
Score = 134 bits (336), Expect = 1e-30
Identities = 170/849 (20%), Positives = 374/849 (44%), Gaps = 100/849 (11%)
Query: 7 VIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 66
++ + N KC LK+ + + + + + E ++NL E L+++I + +
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 67 RKVAIEGKLEISNTFAALENEVSALISENKKLKQ--DILEE--QAQGKICDQLKKCEKVV 122
+K E + + E++V+ LI N KL+Q D LE + + K+ L++ ++ +
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059
Query: 123 EGRNALRQ-AVKILEKRIENLESENKKLKKDIQEEQAQ------RKIEIEGKLEKSNA-F 174
EG + Q ++ LE + +E + KK + ++ + QA+ ++ + K+++ A
Sbjct: 1060 EGDLKMSQESIMDLENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARI 1119
Query: 175 AALENEVSA---LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENK 231
LE E+ A L+++ +K + D+ E + +E E S A +A ++E +
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE---EASGATSAQIEMNKKREAEFQ 1176
Query: 232 KLKQDILDE--QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDI 289
K+++D+ + Q + KK+ + V E L + + L++ + LE E +LK +I
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAE----LGEQIDNLQRVKQKLEKEKSELKMEI 1232
Query: 290 QEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 349
+ + + + K I +E++ S +K+++++ + I + Q+ E+S
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292
Query: 350 NAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEK 409
+ E+ +S L + L Q + ++LK++ E+ + +NA+ A
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQL----------EELKRQMEEETKAKNAMAHA------ 1336
Query: 410 GIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILE 469
+++ + L++ +EEQ E K E+ A + +EV+ K TK + D ++
Sbjct: 1337 -LQSSRHDCDLLREQYEEEQ-------EAKAELQRALSKANSEVAQWK---TKYETDAIQ 1385
Query: 470 EQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISD 529
+++ E K +++ E + S+ A+L++ + G+VE L +
Sbjct: 1386 RTEELE---EAKKKLAQRLQEAEEKTETANSKCASLEKT----KQRLQGEVEDLMRDLER 1438
Query: 530 TEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPAN 589
+ TL K+ +K++A E K+ E++ LEAA+K E +
Sbjct: 1439 SHTACATLDKKQRNFDKVLA---------EWKQKLDESQAELEAAQK---------ESRS 1480
Query: 590 CCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKE-NEVSALKSEISAL 648
++ +++ E+V LR+ K L++ I +L + + K E K +
Sbjct: 1481 LSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQE 1540
Query: 649 QQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAA 708
+ E G +E ++ I + E++++K E + +++ E + AA
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE--LDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 709 EARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKK 768
EA + + + AE+ + + L++ +E +NE +++L + E + +
Sbjct: 1599 EALQSV-----LDAEIRSRNDALRLKK-KMEGDLNEMEIQLGHSNRQMAETQRHLRTVQG 1652
Query: 769 KLLVEKINAESKIKKAQERSE-------------SELDKKTADMEKQQAEEQKKLAEDKL 815
+L +++ + ++ ++ E EL++ +E Q E ++L+E +L
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE--QTERTRRLSEQEL 1710
Query: 816 LLLGDSLQL 824
L D +QL
Sbjct: 1711 LDASDRVQL 1719
Score = 133 bits (334), Expect = 2e-30
Identities = 179/858 (20%), Positives = 385/858 (44%), Gaps = 118/858 (13%)
Query: 43 EKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDI 102
EK + ++ + ++ K+++ +A+RK LE ++ +L+ E L+ +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRK--------------ELEEKMVSLLQEKNDLQLQV 895
Query: 103 LEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIE--------------NLESENKK 148
E + D ++CE +++ + L VK L +R+E NLE +
Sbjct: 896 QSETEN--LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 149 LKKDIQE-EQAQRKIE-----IEGKLEK-SNAFAALENEVSALKSENKKLK---KDILEE 198
LK+DI + E K+E E K++ S ALE +S L E K L+ + L++
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 199 QAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVV 258
+ + G ++I+ +++ + KKL+ D+ E+A+ K LK E ++
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADL--ERAKRKLEGDLKMSQESIM 1071
Query: 259 EGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKL-EISNAFAALENEV 317
+ N +Q +E+ ++ E E +L+ I +E ++ + K+ E+ LE E+
Sbjct: 1072 DLENEKQQ----IEEKLKKKEFELSQLQARIDDEQV-HSLQFQKKIKELQARIEELEEEI 1126
Query: 318 SA---LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDIL 374
A L+++ +K + D+ E + +E E S A +A ++E +K+++D+
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISERLE---EASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 375 EE--QAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQR 432
E Q + KK+ + V E L + + L++ + LE E +LK +I + +
Sbjct: 1184 EATLQHEATAATLRKKQADSVAE----LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI 1239
Query: 433 KIEIEGKLEISNAFAALENEVSALKS---ESTKLKKDILEEQAQIKVAIEEKLEISNAFA 489
+ + K I +E++ S +K+ + T+L D+ ++A+++ + E+S+
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQT---QNGELSHRVE 1296
Query: 490 ALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKA---GISDTEKEVNTLKKELVEKEK 546
E+ +S L AL Q+ R+ + + A + + + + L+++ E+++
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 547 IVADSER----------------KTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANC 590
A+ +R +T +R + EA+K L + A EK E AN
Sbjct: 1357 AKAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKT---ETAN- 1412
Query: 591 CSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSA-LKSEISALQ 649
SKC L+K +++ + + ++ LE+ + +KK + ++V A K ++ Q
Sbjct: 1413 -SKCASLEKTKQRL---QGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQ 1468
Query: 650 QKCGAGAREGNG---DVEVLKAGISDTKKEVNRLKKEHVEEERIVAD-SERKTAVDERKN 705
+ A +E ++ ++ + ++ L++E+ + ++D +E+ +
Sbjct: 1469 AELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 706 AAAEARKLLEAPK---KIAAE--------VEKQIAKVELRQVHLEKQVNERKMKLAFELS 754
A + +KL+E K ++A E E +I +V+L ++ +++ + ++ E+
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIE 1588
Query: 755 KTKEATKRFEAEKKKLLVEKINAES---KIKKAQERSESELDKKTADMEKQQAEEQKKL- 810
+ K ++R + +L +I + + ++KK E +E++ + +Q AE Q+ L
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLR 1648
Query: 811 -----AEDKLLLLGDSLQ 823
+D L L D+L+
Sbjct: 1649 TVQGQLKDSQLHLDDALR 1666
Score = 91.3 bits (225), Expect = 9e-18
Identities = 128/640 (20%), Positives = 276/640 (43%), Gaps = 90/640 (14%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
EELK++ E+ +NA+ A +++ + L++ +EEQ E K E+
Sbjct: 1317 EELKRQMEEETKAKNAMAHA-------LQSSRHDCDLLREQYEEEQ-------EAKAELQ 1362
Query: 79 NTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKR 138
+ +EV+ K K + D +++ E++ E + L Q ++ E++
Sbjct: 1363 RALSKANSEVAQW-----KTKYET----------DAIQRTEELEEAKKKLAQRLQEAEEK 1407
Query: 139 IENLESENKKLKKDIQEEQAQRKIEIEGKLEKSN-AFAALENEVSALKSENKKLKKDILE 197
E S+ L+K Q Q + + ++ LE+S+ A A L+ + + K+ + E
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVE-DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDE 1466
Query: 198 EQAQRKVAMEGKLEIS-------NAFAALENEVSALKSENKKLKQDILDEQAQ----GKF 246
QA+ + A + +S NA+ + +++ L+ ENK L+++I D Q GK
Sbjct: 1467 SQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKN 1526
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEHAQRKVE 299
+K + V + ++ L+ A++ +E +E+ ES E ++K ++ + ++ E
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586
Query: 300 IEG-KLEISNAFAALENEVSA-LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 357
IE K A AL++ + A ++S N L+ K MEG L E
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRL---------KKKMEGDLN--------EM 1629
Query: 358 EVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESE 417
E+ S + + QG+ D + + + L++ + I+E+ L E
Sbjct: 1630 EIQLGHSNRQMAETQRHLRTVQGQLKDS-QLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
Query: 418 NKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVA 477
+++K +++ + R++ + L+ S+ L ++ ++L + KL+ DI + QA+++ +
Sbjct: 1689 LEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS 1748
Query: 478 IEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTL 537
I+E + + + E+ Q + + +E +K + T K+ L
Sbjct: 1749 IQESRNAEEKAKKAITDAAMMAEELKKEQ--------DTSAHLERMKKNLEQTVKD---L 1797
Query: 538 KKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDEL 597
+ L E E++ +K + + + E L+ +K A +
Sbjct: 1798 QHRLDEAEQLALKGGKK-QIQKLENRVRELENELDVEQK---------RGAEALKGAHKY 1847
Query: 598 KKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENE 637
++K +++ R+ + L+ ++ L+++ K K++ E
Sbjct: 1848 ERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887
Score = 83.6 bits (205), Expect = 2e-15
Identities = 116/518 (22%), Positives = 235/518 (44%), Gaps = 73/518 (14%)
Query: 311 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 370
A E E++ +K + ++ K+++ +A+RK LE ++ +L E L+
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRK--------------ELEEKMVSLLQEKNDLQ 892
Query: 371 QDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQA 430
L+ Q++ + +++CE +++ KIL LE++ K+L + ++EE+
Sbjct: 893 ---LQVQSETENLMDAEERCEGLIKS--------KIL------LEAKVKELTERLEEEEE 935
Query: 431 QRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLE-ISNAFA 489
+ K + + ++L+ ++ L+ TK++K+ K A E K++ +S
Sbjct: 936 MNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKE--------KHATENKVKNLSEEMT 987
Query: 490 ALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGI-------SDTEKEVNTLKKELV 542
ALE +S L E +LQ+ ++ D++V + + + E++ + L+ L
Sbjct: 988 ALEENISKLTKEKKSLQE----AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 543 EKEKIVADSER-KTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKC 601
+++K+ AD ER K ++ K + E+ LE K+ EK E + +L+ +
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKKE-----FELSQLQARI 1098
Query: 602 EKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNG 661
+ V ++ +K L+ IE LE E ++ E+ + A ++++ ARE
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEE---IEAEHTLRA------KIEKQRSDLARELEE 1149
Query: 662 DVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIA 721
E L+ T ++ KK E +++ D E T E A A L +
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE-----ATAATLRKKQADSV 1204
Query: 722 AEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATK-RFEAEKKKLLVEKINAESK 780
AE+ +QI ++ + LEK+ +E KM++ S + +K + E+ VE +E K
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264
Query: 781 IKKAQE-RSESELDKKTADMEKQQAEEQKKLAEDKLLL 817
K Q+ + +L+ + A ++ Q E ++ E + L+
Sbjct: 1265 AKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
Score = 62.4 bits (150), Expect = 5e-09
Identities = 95/477 (19%), Positives = 204/477 (41%), Gaps = 57/477 (11%)
Query: 2 ASEKAVIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQ 61
A +A E + ++ +++ E+VV LR+ K L++ I +L + + K++Q
Sbjct: 1469 AELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 62 EEQAQRKVAIEGK----LEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKK 117
E + +K+ + K + + +LE+E S ++ +L Q ++ + K+ ++ ++
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ--VKSELDRKVIEKDEE 1586
Query: 118 CEKVVEGRNALRQAVKILEKRIENLESEN------KKLKKDIQE------------EQAQ 159
E++ RN+ R A + + S N KK++ D+ E + Q
Sbjct: 1587 IEQL--KRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQ 1644
Query: 160 RKIE-IEGKLEKS---------------NAFAALENEVSALKSENKKLKKDILEEQAQRK 203
R + ++G+L+ S A +E L E +++K + + + R+
Sbjct: 1645 RHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRR 1704
Query: 204 VAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQG----KFCDRLKKKCEKVVE 259
++ + L+ S+ L ++ ++L + KKL+ DI QA+ + ++K +K +
Sbjct: 1705 LSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAIT 1764
Query: 260 GRNALRQAVKILEKGIENLESENKKLK---KDIQE--EHAQRKVEIEGKLEI---SNAFA 311
+ + +K + +LE K L+ KD+Q + A++ GK +I N
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVR 1824
Query: 312 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 371
LENE+ + + K + + + K E L++ V L+++ K K+
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKR 1884
Query: 372 DILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEE 428
E+A+ + QL +C +V + I E + L ++++ + EE
Sbjct: 1885 Q--AEEAEEQANTQL-SRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>MYH7_HUMAN (P12883) Myosin heavy chain, cardiac muscle beta isoform
(MyHC-beta)
Length = 1935
Score = 134 bits (336), Expect = 1e-30
Identities = 172/808 (21%), Positives = 360/808 (44%), Gaps = 113/808 (13%)
Query: 43 EKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDI 102
EK + +++ E +LK+ +++ +A+RK LE ++ +L+ E L+ +
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRK--------------ELEEKMVSLLQEKNDLQLQV 891
Query: 103 LEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKL---KKDIQEEQAQ 159
E Q + D ++C+++++ + L VK + +R+E+ E N +L K+ +++E ++
Sbjct: 892 QAE--QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 160 RKIEIE------GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 213
K +I+ K+EK A EN+V L E L + I + ++K E +
Sbjct: 950 LKRDIDDLELTLAKVEKEK--HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1007
Query: 214 NAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEK 273
+ A E++V+ L KL+Q + D + ++ KK + + L +K+ ++
Sbjct: 1008 DDLQAEEDKVNTLTKAKVKLEQQVDDLEGS---LEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 274 GIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILE 333
I +LE++ ++L + ++++ E++ A +E+E + KKLK
Sbjct: 1065 SIMDLENDKQQLDERLKKK----------DFELNALNARIEDEQALGSQLQKKLK----- 1109
Query: 334 EQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKV 393
E + I LE+E +A +++ +KL+ D+ E L++ E++
Sbjct: 1110 ---------ELQARIEELEEELESERTA-RAKVEKLRSDLSRE---------LEEISERL 1150
Query: 394 VEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEG-KLEISNAFAALENE 452
E A +++ +K E+E +K+++D++E Q + + + +++ A L +
Sbjct: 1151 EEAGGATSVQIEMNKK----REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206
Query: 453 VSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAG 512
+ L+ KL+K+ E + ++ +I A A LE L+ ++ + K
Sbjct: 1207 IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK---- 1262
Query: 513 SREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLE 572
+ E V L + + + E L ++L EKE +++ R ++ + ++ LE
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ--LEDLKRQLE 1320
Query: 573 AAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKL 632
+++ + A+ + CD L+++ E+ + L+ ++L K N E +
Sbjct: 1321 --EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ---RVLSKA--NSEVAQWRT 1373
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
K E + E+ ++K +E VE + A S +K +RL+ E E ++
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN---EIEDLMV 1430
Query: 693 DSERKTA---------------VDERKNAAAEARKLLEAPKKIAAEVEKQIAKV----EL 733
D ER A + E K E++ LE+ +K A + ++ K+ E
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490
Query: 734 RQVHLE------KQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQ-- 785
HLE K + E L +L + + E +K+L EK+ +S +++A+
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550
Query: 786 -ERSESELDKKTADMEKQQAEEQKKLAE 812
E E ++ + + + +AE ++KLAE
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAE 1578
Score = 132 bits (332), Expect = 4e-30
Identities = 201/906 (22%), Positives = 390/906 (42%), Gaps = 121/906 (13%)
Query: 1 MASEKAVIPEPANCCSKCEELKKKCEQVVVG----RNALRQAVKILEKGIENLESENKKL 56
MAS K K E +K+ E+ +V +N L+ V+ + + + E +L
Sbjct: 849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 908
Query: 57 KKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLK 116
K+ K+ +E K++ N E E++A ++ K+ +D E + I D
Sbjct: 909 IKN--------KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRD-IDDLEL 959
Query: 117 KCEKVVEGRNALRQAVKILEKRIENLESENKKL---KKDIQEEQAQRKIEIEGKLEKSN- 172
KV + ++A VK L + + L+ KL KK +QE Q +++ + +K N
Sbjct: 960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNT 1019
Query: 173 ---AFAALENEVSALKS---ENKKLKKDILEEQAQRKVAMEGKLEISN-AFAALENEVSA 225
A LE +V L+ + KK++ D+ E+A+RK +EG L+++ + LEN+
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDL--ERAKRK--LEGDLKLTQESIMDLENDKQQ 1075
Query: 226 LKSENKK-------LKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENL 278
L KK L I DEQA G +L+KK ++ L+ ++ LE+ +E+
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGS---QLQKKLKE-------LQARIEELEEELESE 1125
Query: 279 ESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALK-SENKKLKKDILEEQAQ 337
+ K++K ++ + ++ EI +LE + +++ E++ + +E +K+++D+ E Q
Sbjct: 1126 RTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 338 --------RKVAMEGKLEISNAFAALENEVSALKSENKKLKQDI------LEEQAQGKFC 383
RK + E+ L+ L+ E + K ++ +E+ + K
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA- 1243
Query: 384 DQLKKKCEKVVEGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEQAQRKIEI 436
L+K C + + N R + ++ + +L S EN +L + + E++A
Sbjct: 1244 -NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Query: 437 EGKL----EISNAFAALENEVSALKS-----ESTKLKKDIL----EEQAQIKVAIEEKLE 483
GKL ++ + LE EV A + +S + D+L EE+ + K ++ L
Sbjct: 1303 RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362
Query: 484 ISNAFAA-----LENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLK 538
+N+ A E + E+ ++K +E VE + A S EK + L+
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQ 1422
Query: 539 KELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELK 598
E+ E ++ D ER A AAA +K K +A K E S+ + +
Sbjct: 1423 NEI---EDLMVDVERSNAA-----AAALDKKQRNFDKILAEWKQKYEESQ---SELESSQ 1471
Query: 599 KKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKE---------------NEVSALKS 643
K+ ++ L+ A + + +E + ENK L++E +E+ ++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 644 EISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDER 703
++ A + + + E +E + I + E N++K E +E + D E + A
Sbjct: 1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE-IERKLAEKDEEMEQAKRNH 1590
Query: 704 KNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRF 763
+ L+A + E + K+E +E Q++ ++A E K ++ +
Sbjct: 1591 LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN-RMAAEAQKQVKSLQSL 1649
Query: 764 EAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEK-----QQAEEQKKLAEDKLLLL 818
+ + L + + A +K+ E + A++E+ +Q E +KLAE +L+
Sbjct: 1650 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Query: 819 GDSLQL 824
+ +QL
Sbjct: 1710 SERVQL 1715
Score = 122 bits (306), Expect = 4e-27
Identities = 156/667 (23%), Positives = 305/667 (45%), Gaps = 81/667 (12%)
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
A E E++++K E +LK+ + + +A+RK LE ++ +L E L+
Sbjct: 843 AEREKEMASMKEEFTRLKEALEKSEARRK--------------ELEEKMVSLLQEKNDLQ 888
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL---KKDIQE 291
L QA+ +++C+++++ + L VK + + +E+ E N +L K+ +++
Sbjct: 889 ---LQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 292 EHAQRKVEIEGKLEISNAFA-----ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKL 346
E ++ K +I+ LE++ A A EN+V L E L + I + ++K E
Sbjct: 946 ECSELKRDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 347 EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKI 406
+ + A E++V+ L KL+Q + + +G +Q KK + + L +K+
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQV--DDLEGSL-EQEKKVRMDLERAKRKLEGDLKL 1061
Query: 407 LEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKD 466
++ I +LE++ ++L +E+ ++K E++ A +E+E ++ ++L+K
Sbjct: 1062 TQESIMDLENDKQQL-----DERLKKK-----DFELNALNARIEDE----QALGSQLQKK 1107
Query: 467 ILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAG 526
+ E QA+I+ +EE+LE A +V L+S+++ ++ E G V
Sbjct: 1108 LKELQARIE-ELEEELESERTARA---KVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 527 ISDTEKEVNTLKKELVE---KEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAV 583
E E ++++L E + + A + RK D + + L +K+ EK+
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 584 IP-EPANCCSKCDE-------LKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKE 635
E + S ++ L+K C + N R + ++ + +L S+ KL+ E
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 636 N-EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADS 694
N E+S E AL + G +E LK + + K N L ++ R D
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL-AHALQSARHDCDL 1342
Query: 695 ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELS 754
R+ +E A AE +++L K +EV + K E + +++ E K KLA L
Sbjct: 1343 LRE-QYEEETEAKAELQRVL---SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 755 KTKEATKRFEAEKKKLLVEKINAE-SKIKKAQERSESELDKKTADMEKQQAE----EQKK 809
+ +EA VE +NA+ S ++K + R ++E++ D+E+ A ++K+
Sbjct: 1399 EAEEA------------VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 810 LAEDKLL 816
DK+L
Sbjct: 1447 RNFDKIL 1453
Score = 120 bits (301), Expect = 1e-26
Identities = 202/901 (22%), Positives = 389/901 (42%), Gaps = 154/901 (17%)
Query: 33 NALRQAVKILEKGIENLES---ENKKLKKDIQEEQAQRKVAIEGKLEISN-TFAALENEV 88
N L +A LE+ +++LE + KK++ D+ E+A+RK +EG L+++ + LEN+
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL--ERAKRK--LEGDLKLTQESIMDLENDK 1073
Query: 89 SALISENKK-------LKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIEN 141
L KK L I +EQA G QL+K K ++ R ++ LE+ +E+
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGS---QLQKKLKELQAR------IEELEEELES 1124
Query: 142 LESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALK-SENKKLKKDILEEQA 200
+ K++K ++ + ++ EI +LE++ +++ E++ + +E +K+++D+ E
Sbjct: 1125 ERTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Query: 201 Q--------RKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQG----KFCD 248
Q RK + E+ L+ L+ E + K ++ D + K
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 249 RLKKKCEKVVEGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEHAQRKVEIE 301
L+K C + + N R + ++ + +L S EN +L + + E+ A
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTR 1303
Query: 302 GKL----EISNAFAALENEVSALKSENKKLKK-----DILEEQAQRKVAMEGKLEISNAF 352
GKL ++ + LE EV A + L+ D+L EQ + + E K E+
Sbjct: 1304 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEET--EAKAELQRVL 1361
Query: 353 AALENEVSA--LKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKG 410
+ +EV+ K E +++ E+A+ K +L++ E+ VE NA + LEK
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE-AEEAVEAVNAKCSS---LEKT 1417
Query: 411 IENLESENKKLKKDIQEEQA--------QR---KIEIEGKLEISNAFAALENEVSALKSE 459
L++E + L D++ A QR KI E K + + + LE+ +S
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 460 STKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGD 519
ST+L K +K A EE LE F + E L+ EI+ L ++ G+ +
Sbjct: 1478 STELFK--------LKNAYEESLEHLETF---KRENKNLQEEISDLTEQLGSSGKT---- 1522
Query: 520 VEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK--KAAAEARKLLEAAKKI 577
I + EK L+ E +E + + ++E +E K +A E ++ ++
Sbjct: 1523 -------IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1575
Query: 578 APEKAVIPEPA--NCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE-----SENK 630
EK E A N D L+ + RN + K +E + +E +
Sbjct: 1576 LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 631 KLKKENEVSALKSEISALQQKCGAGAREGN-----------------GDVEVLKAGISDT 673
+ + +V +L+S + Q + R + ++E L+A + T
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Query: 674 KKEVNRLKKEHVE------------------EERIVAD-----SERKTAVDERKNAAAEA 710
++ ++E +E ++++ AD +E + AV E +NA +A
Sbjct: 1696 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA 1755
Query: 711 RKLLEAPKKIAAEVEKQ---IAKVELRQVHLEKQVNERKMKL----AFELSKTKEATKRF 763
+K + +A E++K+ A +E + ++E+ + + + +L L K+ ++
Sbjct: 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1815
Query: 764 EAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQ 823
EA ++ L ++ AE K + + +++ ++ Q E++K L +L L D LQ
Sbjct: 1816 EARVRE-LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLL--RLQDLVDKLQ 1872
Query: 824 L 824
L
Sbjct: 1873 L 1873
Score = 67.0 bits (162), Expect = 2e-10
Identities = 79/418 (18%), Positives = 184/418 (43%), Gaps = 57/418 (13%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
K E +K E+ A R +++++ +L++E + + E + K +EG L
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS-----RNEALRVKKKMEGDLN 1623
Query: 77 ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ N ++A + K Q +L+ D + + V + L++ + I+E
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLK--------DTQIQLDDAVRANDDLKENIAIVE 1675
Query: 137 KRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDIL 196
+R L++E ++L+ +++ + RK+ + +E S L ++ ++L ++ KK+ D+
Sbjct: 1676 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLS 1735
Query: 197 EEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEK 256
+ Q + + A++ E NA E + ++ + +++ EQ +R+KK E+
Sbjct: 1736 QLQTEVEEAVQ---ECRNA----EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788
Query: 257 VVEG-RNALRQAVKILEKG----IENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA 311
++ ++ L +A +I KG ++ LE+ ++L+ +++ E + ++G
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKG--------- 1839
Query: 312 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 371
++ +++K+ + + RK L + + L+ +V A K + ++
Sbjct: 1840 --------MRKSERRIKELTYQTEEDRK----NLLRLQDLVDKLQLKVKAYKRQAEE--- 1884
Query: 372 DILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL-KKDIQEE 428
EEQA K KV + + I E + L ++++ + K + EE
Sbjct: 1885 --AEEQANTNL-----SKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 58.2 bits (139), Expect = 9e-08
Identities = 67/324 (20%), Positives = 162/324 (49%), Gaps = 40/324 (12%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
S ++ + + + V + L++ + I+E+ L++E ++L+ +++ + RK+A + +
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVE-GRNALRQAVKI 134
E S L ++ ++LI++ KK+ D+ Q Q ++ + +++C E + A+ A +
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADL--SQLQTEVEEAVQECRNAEEKAKKAITDAAMM 1765
Query: 135 LE--KRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLK 192
E K+ ++ + +++KK+++ Q +++ +L+ E E ALK K+L+
Sbjct: 1766 AEELKKEQDTSAHLERMKKNME----QTIKDLQHRLD--------EAEQIALKGGKKQLQ 1813
Query: 193 KDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKK 252
K LE + + +E +LE A V ++ +++K+ + K RL+
Sbjct: 1814 K--LEARVRE---LENELEAEQKRNA--ESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Query: 253 KCEKV-VEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA 311
+K+ ++ + RQA + E+ NL S+ +K++ ++ E A+ + +I
Sbjct: 1867 LVDKLQLKVKAYKRQAEEAEEQANTNL-SKFRKVQHELDE--AEERADI----------- 1912
Query: 312 ALENEVSALKSENKKLKKDILEEQ 335
E++V+ L+++++ + L E+
Sbjct: 1913 -AESQVNKLRAKSRDIGTKGLNEE 1935
>MYH7_PIG (P79293) Myosin heavy chain, cardiac muscle beta isoform
(MyHC-beta)
Length = 1935
Score = 133 bits (335), Expect = 2e-30
Identities = 179/852 (21%), Positives = 368/852 (43%), Gaps = 110/852 (12%)
Query: 43 EKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDI 102
EK + ++ E +LK+ +++ +A+RK LE ++ +L+ E L+ +
Sbjct: 846 EKEMATMKEEFGRLKEALEKSEARRK--------------ELEEKMVSLLQEKNDLQLQV 891
Query: 103 LEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKL---KKDIQEEQAQ 159
EQ + D ++C+++++ + L VK + +R+E+ E N +L K+++++E ++
Sbjct: 892 QAEQ--DNLSDSEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRNVEDECSE 949
Query: 160 RKIEIE------GKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEIS 213
K +I+ K+EK A EN+V L E L + I + ++K E +
Sbjct: 950 LKRDIDDLELTLAKVEKEK--HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1007
Query: 214 NAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEK 273
+ A E++V+ L KL+Q + D ++ KK + + L +K+ ++
Sbjct: 1008 DDLQAEEDKVNTLTKAKVKLEQHVDDLAGS---LEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 274 GIENLESENKKL-----KKDIQEEHAQRKVEIEGKL---------EISNAFAALENEVSA 319
I +LE++ ++L KKD + ++E E L E+ LE E+ A
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 320 LKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK-SENKKLKQDILEE-- 376
++ K++K + + ++ + +LE + +++ E++ + +E +K+++D+ E
Sbjct: 1125 ERTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Query: 377 QAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEI 436
Q + KK + V E L + + L++ + LE E + K ++ + + + I
Sbjct: 1184 QHEATAAALRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 437 EGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVS 496
+ K + LE++++ +S++ + ++ + + +Q KL+ N E+S
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ-----RAKLQTEN------GELS 1288
Query: 497 ALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTA 556
E AL + G +E LK + + K N L L + + AD R+
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHAL-QSARHAADLLREQY 1347
Query: 557 VDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVK 616
+E + A R L +A ++A + A + +EL++ +K+A +AV+
Sbjct: 1348 EEETETKAELQRVLSKANSEVAQWRTKYETDA--IQRTEELEEAKKKLAQRLQDAEEAVE 1405
Query: 617 ILEKGIENLESENKKLKKENE--------VSALKSEISALQQKCGAGAREGNGDVEVLKA 668
+ +LE +L+ E E +A + + Q+ E E ++
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 669 GISDTKKEVNRLKKEHVEEERIVADS--ERKTAVDERKNAAAEARKLLE---APKKIAAE 723
+ ++KE L E + + +S +T+ E KN E L E + K E
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETSKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 724 VEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRF---EAEKKKLLVEK------ 774
+EK ++E ++ L+ + E + L E K A F +AE ++ L EK
Sbjct: 1526 LEKVRKQLEAEKLELQSALEESEASLEHEEGKILRAQLEFNQIKAEMERKLAEKDEEMEQ 1585
Query: 775 ---------------INAES-------KIKKAQERSESELDKKTADMEKQQAEEQKKLAE 812
++AE+ ++KK E +E++ + + + AE QK++
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645
Query: 813 DKLLLLGDSLQL 824
+ LL +QL
Sbjct: 1646 LQSLLKDTQIQL 1657
Score = 122 bits (306), Expect = 4e-27
Identities = 156/667 (23%), Positives = 303/667 (45%), Gaps = 81/667 (12%)
Query: 175 AALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLK 234
A E E++ +K E +LK+ + + +A+RK LE ++ +L E L+
Sbjct: 843 AETEKEMATMKEEFGRLKEALEKSEARRK--------------ELEEKMVSLLQEKNDLQ 888
Query: 235 QDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL---KKDIQE 291
L QA+ +++C+++++ + L VK + + +E+ E N +L K+++++
Sbjct: 889 ---LQVQAEQDNLSDSEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRNVED 945
Query: 292 EHAQRKVEIEGKLEISNAFA-----ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKL 346
E ++ K +I+ LE++ A A EN+V L E L + I + ++K E
Sbjct: 946 ECSELKRDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 347 EISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKI 406
+ + A E++V+ L KL+Q + + G +Q KK + + L +K+
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQHV--DDLAGSL-EQEKKVRMDLERAKRKLEGDLKL 1061
Query: 407 LEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKD 466
++ I +LE++ ++L +E+ ++K E++ A +E+E ++ ++L+K
Sbjct: 1062 TQESIMDLENDKQQL-----DERLKKK-----DFELNALNARIEDE----QALGSQLQKK 1107
Query: 467 ILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAG 526
+ E QA+I+ +EE+LE A +V L+S+++ ++ E G V
Sbjct: 1108 LKELQARIE-ELEEELEAERTARA---KVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 527 ISDTEKEVNTLKKELVE---KEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPEKAV 583
E E ++++L E + + A + RK D + + L +K+ EK+
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 584 IP-EPANCCSKCDE-------LKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKE 635
E + S ++ L+K C + N R + ++ + +L S+ KL+ E
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 636 N-EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADS 694
N E+S E AL + G +E LK + + K N L ++ R AD
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL-AHALQSARHAADL 1342
Query: 695 ERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELS 754
R+ +E AE +++L K +EV + K E + +++ E K KLA L
Sbjct: 1343 LRE-QYEEETETKAELQRVL---SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 755 KTKEATKRFEAEKKKLLVEKINAE-SKIKKAQERSESELDKKTADMEKQQAE----EQKK 809
+EA VE +NA+ S ++K + R ++E++ D+E+ A ++K+
Sbjct: 1399 DAEEA------------VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 810 LAEDKLL 816
DK+L
Sbjct: 1447 RNFDKIL 1453
Score = 117 bits (292), Expect = 2e-25
Identities = 202/928 (21%), Positives = 387/928 (40%), Gaps = 162/928 (17%)
Query: 13 NCCSKCEELKKKCE-------QVVVGRNALRQAVKILEK---GIENLESENKKLKKDIQE 62
N +C ELK+ + +V ++A VK L + G++ + ++ K KK +QE
Sbjct: 942 NVEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Query: 63 EQAQRKVAIEGKLEISNTF----AALENEVSAL---ISENKKLKQDI------LE----- 104
Q ++ + + NT LE V L + + KK++ D+ LE
Sbjct: 1002 AHQQALDDLQAEEDKVNTLTKAKVKLEQHVDDLAGSLEQEKKVRMDLERAKRKLEGDLKL 1061
Query: 105 --------EQAQGKICDQLKKCEKVVEGRNA-----------LRQAVKILEKRIENLESE 145
E + ++ ++LKK + + NA L++ +K L+ RIE LE E
Sbjct: 1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE 1121
Query: 146 ----------NKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALK-SENKKLKKD 194
+KL+ D+ E EI +LE++ +++ E++ + +E +K+++D
Sbjct: 1122 LEAERTARAKVEKLRSDLSRELE----EISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177
Query: 195 ILEEQAQ--------RKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQG-- 244
+ E Q RK + E+ L+ L+ E + K ++ D +
Sbjct: 1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1237
Query: 245 --KFCDRLKKKCEKVVEGRNALRQAVKILEKGIEN-------LESENKKLKKDIQEEHAQ 295
K L+K C + + N R + ++ + + L++EN +L + + E+ A
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297
Query: 296 RKVEIEGKL----EISNAFAALENEVSALKS-----ENKKLKKDILEEQAQRKVAMEGKL 346
GKL ++ + LE EV A + ++ + D+L EQ + + E K
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHAADLLREQYEEET--ETKA 1355
Query: 347 EISNAFAALENEVS--ALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAV 404
E+ + +EV+ K E +++ E+A+ K +L + E+ VE NA
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL-QDAEEAVEAVNA---KC 1411
Query: 405 KILEKGIENLESENKKLKKDIQEEQA--------QR---KIEIEGKLEISNAFAALENEV 453
LEK L++E + L D++ A QR KI E K + + + LE+
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 454 SALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGS 513
+S ST+L K +K A EE LE + E L+ EI+ L ++ G+
Sbjct: 1472 KEARSLSTELFK--------LKNAYEESLE---HLETSKRENKNLQEEISDLTEQLGSSG 1520
Query: 514 REGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK--KAAAEARKLL 571
+ I + EK L+ E +E + + +SE +E K +A E ++
Sbjct: 1521 KT-----------IHELEKVRKQLEAEKLELQSALEESEASLEHEEGKILRAQLEFNQIK 1569
Query: 572 EAAKKIAPEKAVIPEPA--NCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE--- 626
++ EK E A N D L+ + RN + K +E + +E
Sbjct: 1570 AEMERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 627 --SENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVE-----------VLKAGISDT 673
+ + + +V +L+S + Q + R N D++ +L+A + +
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 674 KKEVNRLKKEH-VEEERIVADSERKTAVDERKNAAAEARKLLEAP-KKIAAEVEKQIAKV 731
+ V + ++ + E+ ++ SER + + + +K +EA ++ EVE+ + +
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMEADLSQLQTEVEEAVQES 1748
Query: 732 ELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKL------LVEKIN-AESKIKKA 784
+ +K + + M +A EL K ++ + E KK + L +++ AE K
Sbjct: 1749 RNAEEKAKKAITDAAM-MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 785 QERSESELDKKTADMEKQQAEEQKKLAE 812
++ +L+ + ++E + EQK+ AE
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAE 1835
Score = 115 bits (289), Expect = 4e-25
Identities = 200/901 (22%), Positives = 386/901 (42%), Gaps = 154/901 (17%)
Query: 33 NALRQAVKILEKGIENLES---ENKKLKKDIQEEQAQRKVAIEGKLEISN-TFAALENEV 88
N L +A LE+ +++L + KK++ D+ E+A+RK +EG L+++ + LEN+
Sbjct: 1018 NTLTKAKVKLEQHVDDLAGSLEQEKKVRMDL--ERAKRK--LEGDLKLTQESIMDLENDK 1073
Query: 89 SALISENKK-------LKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIEN 141
L KK L I +EQA G QL+K K ++ R ++ LE+ +E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGS---QLQKKLKELQAR------IEELEEELEA 1124
Query: 142 LESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALK-SENKKLKKDILEEQA 200
+ K++K ++ + ++ EI +LE++ +++ E++ + +E +K+++D+ E
Sbjct: 1125 ERTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Query: 201 Q--------RKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQG----KFCD 248
Q RK + E+ L+ L+ E + K ++ D + K
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 249 RLKKKCEKVVEGRNALRQAVKILEKGIENLES-------ENKKLKKDIQEEHAQRKVEIE 301
L+K C + + N R + ++ + +L S EN +L + + E+ A
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTR 1303
Query: 302 GKL----EISNAFAALENEVSALKS-----ENKKLKKDILEEQAQRKVAMEGKLEISNAF 352
GKL ++ + LE EV A + ++ + D+L EQ + + E K E+
Sbjct: 1304 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHAADLLREQYEEET--ETKAELQRVL 1361
Query: 353 AALENEVSA--LKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKG 410
+ +EV+ K E +++ E+A+ K +L+ E+ VE NA + LEK
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD-AEEAVEAVNAKCSS---LEKT 1417
Query: 411 IENLESENKKLKKDIQEEQA--------QR---KIEIEGKLEISNAFAALENEVSALKSE 459
L++E + L D++ A QR KI E K + + + LE+ +S
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 460 STKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGD 519
ST+L K +K A EE LE + E L+ EI+ L ++ G+ +
Sbjct: 1478 STELFK--------LKNAYEESLE---HLETSKRENKNLQEEISDLTEQLGSSGKT---- 1522
Query: 520 VEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERK--KAAAEARKLLEAAKKI 577
I + EK L+ E +E + + +SE +E K +A E ++ ++
Sbjct: 1523 -------IHELEKVRKQLEAEKLELQSALEESEASLEHEEGKILRAQLEFNQIKAEMERK 1575
Query: 578 APEKAVIPEPA--NCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE-----SENK 630
EK E A N D L+ + RN + K +E + +E +
Sbjct: 1576 LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 631 KLKKENEVSALKSEISALQQKCGAGAREGN-----------------GDVEVLKAGISDT 673
+ + +V +L+S + Q + R + ++E L+A + T
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Query: 674 KKEVNRLKKEHVE------------------EERIVAD-----SERKTAVDERKNAAAEA 710
++ ++E +E ++++ AD +E + AV E +NA +A
Sbjct: 1696 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMEADLSQLQTEVEEAVQESRNAEEKA 1755
Query: 711 RKLLEAPKKIAAEVEKQ---IAKVELRQVHLEKQVNERKMKL----AFELSKTKEATKRF 763
+K + +A E++K+ A +E + ++E+ + + + +L L K+ ++
Sbjct: 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1815
Query: 764 EAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQ 823
EA ++ L ++ AE K + + +++ ++ Q E++K L +L L D LQ
Sbjct: 1816 EARVRE-LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLL--RLQDLVDKLQ 1872
Query: 824 L 824
L
Sbjct: 1873 L 1873
Score = 99.0 bits (245), Expect = 5e-20
Identities = 142/738 (19%), Positives = 316/738 (42%), Gaps = 108/738 (14%)
Query: 7 VIPEPANCCSKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ 66
+I AN C L+ + + +++V L L++EN +L + + E++A
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297
Query: 67 RKVAIEGKL----EISNTFAALENEVSALIS-----ENKKLKQDILEEQAQGKI------ 111
GKL ++ + LE EV A + ++ + D+L EQ + +
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHAADLLREQYEEETETKAEL 1357
Query: 112 -------------------CDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKD 152
D +++ E++ E + L Q ++ E+ +E + ++ L+K
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEK- 1416
Query: 153 IQEEQAQRKIE-IEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLE 211
+ + Q +IE + +E+SNA AA AL + + K IL E Q+ + +LE
Sbjct: 1417 -TKHRLQNEIEDLMVDVERSNAAAA------ALDKKQRNFDK-ILAEWKQKYEESQSELE 1468
Query: 212 ISNAFA-ALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEGRNALRQAVKI 270
S A +L E+ LK+ ++ + + + + K L+++ + E + + +
Sbjct: 1469 SSQKEARSLSTELFKLKNAYEESLEHLETSKRENK---NLQEEISDLTEQLGSSGKTIHE 1525
Query: 271 LEKGIENLESENKKLKKDIQE-----EHAQRKVEIEGKLEISNAFAALENEVSALKSENK 325
LEK + LE+E +L+ ++E EH + K+ + +LE + A +E +++ E +
Sbjct: 1526 LEKVRKQLEAEKLELQSALEESEASLEHEEGKI-LRAQLEFNQIKAEMERKLAEKDEEME 1584
Query: 326 KLKKDILEEQAQRKVAMEGKLEISN----AFAALENEVSALKSENKKLKQDILEEQAQGK 381
+ K++ L + +++ + N +E +++ ++ + + E Q Q K
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Query: 382 FCDQLKK----KCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIE 437
L K + + V + L++ + I+E+ L++E ++L+ +++ + RK+ +
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Query: 438 GKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSA 497
+E S L ++ ++L ++ K++ D+ + Q +++ A++E + +
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMEADLSQLQTEVEEAVQESRNAEEKAKKAITDAAM 1764
Query: 498 LKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAV 557
+ E+ Q DT + +KK + E+ + D + + +
Sbjct: 1765 MAEELKKEQ----------------------DTSAHLERMKKNM---EQTIKDLQHR--L 1797
Query: 558 DERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKI 617
DE ++ A + K K++ +A + E N EL+ + ++ A +R++ +
Sbjct: 1798 DEAEQIALKGGK-----KQLQKLEARVRELEN------ELEAEQKRNAESVKGMRKSERR 1846
Query: 618 LEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEV 677
+++ E + K L + L+ + LQ K A R+ E +S +K
Sbjct: 1847 IKELTYQTEEDRKNLLR------LQDLVDKLQLKVKAYNRQAEEAEEQANTNLSKFRKVQ 1900
Query: 678 NRLKKEHVEEERIVADSE 695
+ L + EE +A+S+
Sbjct: 1901 HEL--DEAEERADIAESQ 1916
Score = 88.2 bits (217), Expect = 8e-17
Identities = 115/484 (23%), Positives = 223/484 (45%), Gaps = 47/484 (9%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++ +K E +LK+ + + +A+ K +L++K +++ +N L+ V+ + +
Sbjct: 843 AETEKEMATMKEEFGRLKEALEKSEARRK---ELEEKMVSLLQEKNDLQLQVQAEQDNLS 899
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQA 472
+ E +L K+ + +A+ K E + A L + ++ E ++LK+DI + +
Sbjct: 900 DSEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRNVEDECSELKRDIDDLEL 959
Query: 473 QIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEK 532
+ +EK A EN+V L E+A L + ++E E + + D +
Sbjct: 960 TLAKVEKEK-------HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 533 E---VNTLKKELVEKEKIVADSERKTAVDERKKAAAE-ARKLLEAAKKIAPEKAVIPEPA 588
E VNTL K V+ E+ V D +++ + E A++ LE K+ E I +
Sbjct: 1013 EEDKVNTLTKAKVKLEQHVDDLAGSLEQEKKVRMDLERAKRKLEGDLKLTQES--IMDLE 1070
Query: 589 NCCSKCDE-LKKKC-----------EKVAVGRNALRQAVKILEKGIENLESE-NKKLKKE 635
N + DE LKKK ++ A+G + L++ +K L+ IE LE E +
Sbjct: 1071 NDKQQLDERLKKKDFELNALNARIEDEQALG-SQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 636 NEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSE 695
+V L+S++S ++ E G V ++ KK E +++ D E
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSV----------QIEMNKKREAEFQKMRRDLE 1179
Query: 696 RKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSK 755
T + AAA +K ++ AE+ +QI ++ + LEK+ +E K++L S
Sbjct: 1180 EAT-LQHEATAAALRKKHADS----VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1234
Query: 756 TKEATK-RFEAEKK-KLLVEKINAESKIKKAQERSESELDKKTADMEKQQAEEQKKLAED 813
++ K + EK + L +++N + +RS ++L + A ++ + E ++L E
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 814 KLLL 817
+ L+
Sbjct: 1295 EALI 1298
Score = 66.2 bits (160), Expect = 3e-10
Identities = 80/418 (19%), Positives = 187/418 (44%), Gaps = 57/418 (13%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
K E +K E+ A R +++++ +L++E + + E + K +EG L
Sbjct: 1569 KAEMERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS-----RNEALRVKKKMEGDLN 1623
Query: 77 ISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKILE 136
+ N ++A + K Q +L+ D + + V + L++ + I+E
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLK--------DTQIQLDDAVRANDDLKENIAIVE 1675
Query: 137 KRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDIL 196
+R L++E ++L+ +++ + RK+ + +E S L ++ ++L ++ KK++ D+
Sbjct: 1676 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMEADLS 1735
Query: 197 EEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEK 256
+ Q + + A++ E NA E + ++ + +++ EQ +R+KK E+
Sbjct: 1736 QLQTEVEEAVQ---ESRNA----EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788
Query: 257 VVEG-RNALRQAVKILEKG----IENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFA 311
++ ++ L +A +I KG ++ LE+ ++L+ +++ E + ++G
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKG-------MR 1841
Query: 312 ALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQ 371
E + L + ++ +K++L Q + KL++ +K+ N++ ++
Sbjct: 1842 KSERRIKELTYQTEEDRKNLLRLQ-----DLVDKLQLK------------VKAYNRQAEE 1884
Query: 372 DILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKL-KKDIQEE 428
EEQA K KV + + I E + L ++++ + K + EE
Sbjct: 1885 --AEEQANTNL-----SKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 57.8 bits (138), Expect = 1e-07
Identities = 69/321 (21%), Positives = 152/321 (46%), Gaps = 34/321 (10%)
Query: 16 SKCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKL 75
S ++ + + + V + L++ + I+E+ L++E ++L+ +++ + RK+A + +
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Query: 76 EISNTFAALENEVSALISENKKLKQDILEEQAQGKICDQLKKCEKVVEGRNALRQAVKIL 135
E S L ++ ++LI++ KK++ D+ + Q + + E V E RNA +A K +
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMEADLSQLQTEVE--------EAVQESRNAEEKAKKAI 1759
Query: 136 EKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDI 195
E K+ E+ ++ +E + K E E ALK K+L+K
Sbjct: 1760 TDAAMMAEELKKEQDTSAHLERMKKNME---QTIKDLQHRLDEAEQIALKGGKKQLQK-- 1814
Query: 196 LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKFCDRLKKKCE 255
LE + + +E +LE A V ++ +++K+ + K RL+ +
Sbjct: 1815 LEARVRE---LENELEAEQKRNA--ESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVD 1869
Query: 256 KV-VEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALE 314
K+ ++ + RQA + E+ NL S+ +K++ ++ E A+ + +I E
Sbjct: 1870 KLQLKVKAYNRQAEEAEEQANTNL-SKFRKVQHELDE--AEERADI------------AE 1914
Query: 315 NEVSALKSENKKLKKDILEEQ 335
++V+ L+++++ + L E+
Sbjct: 1915 SQVNKLRAKSRDIGTKGLNEE 1935
>MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 133 bits (334), Expect = 2e-30
Identities = 182/859 (21%), Positives = 376/859 (43%), Gaps = 146/859 (16%)
Query: 47 ENLESENKK-------LKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLK 99
+ L++E KK L++ ++EE+A R+ K+ LE+E+ + +N KL
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 100 QD--ILEEQAQG---KICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKK--- 151
++ +LEE+ + ++ +K + + + +N + LE R++ E ++L+K
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 152 --------------DIQEEQAQRKIEIEGKLEK-SNAFAALENEVSALKSENKK------ 190
D+Q + A+ K+++ K E+ A A L++E++ + KK
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 191 ----LKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQGKF 246
L++D+ E+A R A + K ++ AL+ E+ +D LD A +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL-----------EDTLDSTATQQ- 1166
Query: 247 CDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLE- 305
E R Q V +L+K ++ ++ ++++++HAQ E+ +LE
Sbjct: 1167 ------------ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 306 ISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSE 365
A A L+ L+ EN L ++ +V + K E+ + LE +V L+S+
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGEL-------RVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 366 NKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQ----AVKILEKGIENLESENKKL 421
E+A+ + D++ K +V L + A+K L K + +L S+ +
Sbjct: 1268 CSD------GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK-LAKDVASLSSQLQDT 1320
Query: 422 KKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSE-------STKLKKDILEEQAQI 474
++ +QEE Q KL +S LE E ++L+ + L++ I Q+
Sbjct: 1321 QELLQEETRQ-------KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 475 KVAIEEKLEISNAFAALENEVSALKSEI----------AALQQKCGAGSREGNGDVEVLK 524
+ ++ + ++ ALE + EI AA K +++ L
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 525 AGISDTEKEVNTLKKELVEKEKIVADSERKTA--VDERKKAAAEAR-------------- 568
+ + + V+ L+K+ + ++++A+ + ++ DER +A AEAR
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 569 KLLEAAKKI-APEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLE- 626
+ LEA +++ K + E + S D++ K ++ + AL ++ ++ +E LE
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 627 ----SENKKLKKENEVSALKS----EISALQQKCGAGAREGNGDVEVLKAGISDTKKE-- 676
+E+ KL+ E + ALK ++ A ++ R+ + + + D +K+
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 677 VNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQV 736
+ K+ +E + + + +A+ R+ A + RKL K E+E A+ ++
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED--ARASRDEI 1671
Query: 737 HLEKQVNERK--------MKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERS 788
+ NE+K M+L +L+ + A K+ + EK++ L E++ + + A +
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-LAEELASSLSGRNALQDE 1730
Query: 789 ESELDKKTADMEKQQAEEQ 807
+ L+ + A +E++ EEQ
Sbjct: 1731 KRRLEARIAQLEEELEEEQ 1749
Score = 119 bits (299), Expect = 2e-26
Identities = 182/842 (21%), Positives = 361/842 (42%), Gaps = 152/842 (18%)
Query: 24 KCEQVVVGRNA-LRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFA 82
K +Q + NA L +++L + + +E + KKL+ +QE Q++ + E+++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 83 ALENEVSALI-----SENKKLK---------------QDILEEQAQGKICDQLKKCEKVV 122
L+NEV ++ +E K +K Q++L+E+ + K+ + K ++
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL-NVSTKLRQLE 1342
Query: 123 EGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVS 182
E RN+L+ + E + K++++ + I++ +K FA + V
Sbjct: 1343 EERNSLQDQL-----------DEEMEAKQNLERHISTLNIQLSDSKKKLQDFA---STVE 1388
Query: 183 ALKSENKKLKKDI--LEEQAQRKVAMEGKL---------EISNAFAALENE---VSALKS 228
AL+ K+ +K+I L +Q + K A KL E+ + L+N+ VS L+
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 229 ENKKLKQDILDEQ-AQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGI---ENLESENKK 284
+ +K Q + +E+ K+ D + + E + LE+ + E LE NK
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 285 LKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEG 344
LK ++++ + K ++ LE AL+++ +++K + E
Sbjct: 1509 LKAEMED-------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE----------- 1550
Query: 345 KLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAV 404
LE+E+ A +E+ KL+ ++ + +G+F L+ + E+ E R L++ +
Sbjct: 1551 ----------LEDELQA--TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 405 KILEKGIENLESE-------NKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALK 457
E +E+ + KKL+ D+++ + Q I+G+ E A+K
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE-------------AIK 1645
Query: 458 SESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGN 517
+ KL+ + + Q +++ A + EI E + +L++++ LQ+ A R
Sbjct: 1646 -QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER--- 1701
Query: 518 GDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKI 577
K+ + K+EL E E + S R DE+++ A +L
Sbjct: 1702 ------------ARKQADLEKEELAE-ELASSLSGRNALQDEKRRLEARIAQL------- 1741
Query: 578 APEKAVIPEPANCCSKCDELKKKCEKVAVGRNAL---RQAVKILEKGIENLESENKKLK- 633
E+ + E N + D ++K ++ N L R + E + LE +NK+L+
Sbjct: 1742 --EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 634 KENEV-----SALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKK--EHVE 686
K +E+ S KS I+AL+ K + + +A K++ +LK+ VE
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 687 EERIVADSERKTAVDERKNA-AAEARKLLEAPKKIAAEVEKQIAKVELRQVHLE-KQVNE 744
+ER +A+ ++ A E+ NA + ++ LE AE E Q R++ E + E
Sbjct: 1860 DERKMAEQYKEQA--EKGNARVKQLKRQLE-----EAEEESQRINANRRKLQRELDEATE 1912
Query: 745 RKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDKKTADMEKQQA 804
+ E++ K +R + + + + ++ + + SE E D + AD +A
Sbjct: 1913 SNEAMGREVNALKSKLRR--GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKA 1970
Query: 805 EE 806
E
Sbjct: 1971 SE 1972
Score = 116 bits (291), Expect = 2e-25
Identities = 170/842 (20%), Positives = 352/842 (41%), Gaps = 126/842 (14%)
Query: 44 KGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALISENKKLKQDIL 103
K I LE L++D+ E+A R A + K ++ AL+ E+ + ++ +Q++
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL-DSTATQQELR 1169
Query: 104 EEQAQG-----KICDQLKKCEK--VVEGRNALRQAVKILEKRIE-------NLESENKKL 149
++ Q K D+ + + V E R QAV+ L +++E NL+ + L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 150 KKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGK 209
+K+ + + ++ + K E ++ + KKL+ + E Q++ +
Sbjct: 1230 EKENADLAGELRVLGQAKQE--------------VEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 210 LEISNAFAALENEVSAL-----KSENKKLK---------------QDILDEQAQGKFCDR 249
E+++ L+NEV ++ ++E K +K Q++L E+ + K
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--N 1333
Query: 250 LKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGKLEISNA 309
+ K ++ E RN+L+ + + +NLE L +IQ +++K++
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL--NIQLSDSKKKLQ---------- 1381
Query: 310 FAALENEVSALKSENKKLKKDI--LEEQAQRKVAMEGKL---------EISNAFAALENE 358
+ V AL+ K+ +K+I L +Q + K A KL E+ + L+N+
Sbjct: 1382 --DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 359 ---VSALKSENKKLKQDILEEQ-AQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGI--- 411
VS L+ + +K Q + EE+ K+ D+ + + E + LE+ +
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 412 ENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQ 471
E LE NK LK ++++ + K ++ LE AL+++ ++K + E +
Sbjct: 1500 EELERTNKMLKAEMED-------LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 472 AQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTE 531
+++ + KL + AL+ + + ++ A ++ R+ + + + D
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 532 KE--VNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLLEAAKKIAPE-KAVIPEPA 588
K+ + K+ +E + + + +A+ R++A + RKL K E +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 589 NCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKE------------N 636
+ E +KK + + L++ + E+ + + E ++L +E +
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER 696
E L++ I+ L+++ E G++E + + ++ +L E E +E
Sbjct: 1730 EKRRLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785
Query: 697 KTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKT 756
ER+N + KL E + ++ + IA +E + LE+QV + +
Sbjct: 1786 ARQQLERQNKELRS-KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 757 KEATKRFE------------AEKKKLLVEKINAESK-IKKAQERSESELDKKTADMEKQQ 803
K+ K+ + AE+ K EK NA K +K+ E +E E + A+ K Q
Sbjct: 1845 KQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 804 AE 805
E
Sbjct: 1905 RE 1906
Score = 114 bits (285), Expect = 1e-24
Identities = 168/748 (22%), Positives = 322/748 (42%), Gaps = 132/748 (17%)
Query: 104 EEQAQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIE 163
EE+ Q K + K E+ + N L++ LE++ L E K++ +EQ Q + E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEE-----KNLLQEQLQAETE 901
Query: 164 IEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEV 223
+ + E E+ + K+ ++IL E ME +LE E+
Sbjct: 902 LYAEAE----------EMRVRLAAKKQELEEILHE-------MEARLEEE------EDRG 938
Query: 224 SALKSENKKLKQDILD--EQAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESE 281
L++E KK+ Q +LD EQ + + R K + EKV +K LE I ++ +
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA-----EAKIKKLEDEILVMDDQ 993
Query: 282 NKKLKKD---IQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENK-KLKKDILEEQAQ 337
N KL K+ ++E + + + E + L+N+ ++ SE + +LKK+ E+ Q
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQ 1051
Query: 338 RKVAMEGKLE-----ISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEK 392
++ KLE A L+ +++ LK + K ++++ + A + D++ +K
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL--QAALARLDDEIAQK--- 1106
Query: 393 VVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENE 452
NAL++ I LE L++D+ E+A R + K ++ AL+ E
Sbjct: 1107 ----NNALKK--------IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 453 VSALKSESTKLKKDILEEQA-QIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGA 511
+ +D L+ A Q ++ + + E++ AL+ E + ++++ ++QK
Sbjct: 1155 L-----------EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 512 GSREGNGDVEVLKAGISDTEKEVNTLKKELVEKEKIVADSERKTAVDERKKAAAEARKLL 571
E +E K ++ +K TL+KE + A E R L
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENAD-------------------LAGELRVLG 1244
Query: 572 EAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVKILEKGIENL-----E 626
+A +++ +K + ++ EL+ KC R L V L+ +E++ E
Sbjct: 1245 QAKQEVEHKKKKLE------AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 627 SENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVE 686
+E K +K +V++L S++ Q+ R+ + + ++E N L+ + E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDE 1354
Query: 687 EERIVADSERKTAV------DERK---NAAAEARKLLEAPKKIAAEVEKQIAKVELRQV- 736
E + ER + D +K + A+ L E K+ E+E + E +
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 737 --HLEKQVNERKMK---LAFELSKTKEATKRFEAEKKK---LLVEKINAESKIKKAQERS 788
LEK N + + L +L ++ E +++K LL E+ N SK ++R+
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 789 ESEL-DKKTADMEKQQAEEQKKLAEDKL 815
E+E +K+T + +A E+ A+++L
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEL 1502
Score = 99.8 bits (247), Expect = 3e-20
Identities = 111/464 (23%), Positives = 227/464 (48%), Gaps = 70/464 (15%)
Query: 21 LKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNT 80
LK + E +V ++ + + V LEK LE++ +++K ++E + + + + KL +
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 81 FAAL----ENEVSALISENKKLKQDILEE--QAQGKICDQLKKCEKVVEGRNALRQAVKI 134
AL E ++ A +N++ ++ + + + + ++ D+ K+ + L +K
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 135 LEKRIENLESENKKLKKDIQEEQAQRKIEIEGKLEKSNA-----FA-ALENEVSA--LKS 186
LE + ++ ++ K +++ QAQ K + + +LE + A FA A ENE A L++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILD-----EQ 241
+ +L++D+ + RK A K E++ A+ + +AL+ E ++L+ I E+
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 242 AQGKF---CDRLKKKCEKVVEGRNAL---RQAVKILEKGIENLESENKKLKKDIQEEHAQ 295
QG DR++K ++ + N L R + E + LE +NK+L+ + E
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE---- 1803
Query: 296 RKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAAL 355
+E K + + AALE +++ L+ + +E++A+ K A
Sbjct: 1804 --MEGAVKSKFKSTIAALEAKIAQLEEQ--------VEQEAREKQAA------------- 1840
Query: 356 ENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLE 415
+LK ++KKLK+ +L+ + + K +Q K++ EK NA VK L++ +E E
Sbjct: 1841 ---TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK----GNA---RVKQLKRQLEEAE 1890
Query: 416 SENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSE 459
E++++ + + QR+++ E + + A+ EV+ALKS+
Sbjct: 1891 EESQRI--NANRRKLQRELD-----EATESNEAMGREVNALKSK 1927
Score = 54.7 bits (130), Expect = 1e-06
Identities = 54/226 (23%), Positives = 112/226 (48%), Gaps = 18/226 (7%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
EEL ++ + GRNAL+ + LE I LE E ++ + +++ + + A + ++S
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 79 NTFA-----ALENEVS--ALISENKKLKQDI--LEEQAQGKICDQLKKCE-KVVEGRNAL 128
N A A +NE + L +NK+L+ + +E + K + E K+ + +
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 129 RQAVKILEKRIENLESENKKLKKDIQEEQAQRKI--EIEGKLEKSNAFAALENEVSALKS 186
Q + + ++L+ ++KKLK+ + + + +RK+ + + + EK NA V LK
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA------RVKQLKR 1884
Query: 187 ENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKK 232
+ ++ +++ A R+ E + + A+ EV+ALKS+ ++
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 52.0 bits (123), Expect = 6e-06
Identities = 49/190 (25%), Positives = 96/190 (49%), Gaps = 30/190 (15%)
Query: 633 KKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVA 692
++E E+ A + E+ QK ++ +++ L+ S +E N L+++ E + A
Sbjct: 849 RQEEEMQAKEDEL----QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 693 DSERKTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFE 752
++E + R AA+ ++L E I E+E ++ + E R L+ ERK K+A +
Sbjct: 905 EAE-----EMRVRLAAKKQELEE----ILHEMEARLEEEEDRGQQLQA---ERK-KMAQQ 951
Query: 753 LSKTKEATKRFEAEKKKLLVEKINAESKIKKAQE-------------RSESELDKKTADM 799
+ +E + EA ++KL +EK+ AE+KIKK ++ + L+++ +D+
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 800 EKQQAEEQKK 809
AEE++K
Sbjct: 1012 TTNLAEEEEK 1021
Score = 48.1 bits (113), Expect = 9e-05
Identities = 35/146 (23%), Positives = 78/146 (52%), Gaps = 14/146 (9%)
Query: 676 EVNRLKKEHVEEERIVADSERK-TAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELR 734
E+ + K+ + E + + E+K + + E KN E L+A ++ AE E+ ++ +
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAEAEEMRVRLAAK 916
Query: 735 QVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLVEKINAESKIKKAQERSESELDK 794
+ LE+ ++E + +L E ++ ++ +AE+KK+ + ++ E +++ E E +
Sbjct: 917 KQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQMLDLEEQLE------EEEAAR 966
Query: 795 KTADMEKQQAEEQKKLAEDKLLLLGD 820
+ +EK AE + K ED++L++ D
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDD 992
>MYH4_RABIT (Q28641) Myosin heavy chain, skeletal muscle, juvenile
Length = 1938
Score = 132 bits (333), Expect = 3e-30
Identities = 176/837 (21%), Positives = 366/837 (43%), Gaps = 96/837 (11%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLE 76
+C ELKK + + + + + E ++NL E L + I + ++K E +
Sbjct: 949 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1008
Query: 77 ISNTFAALENEVSALISENKKLKQ--DILEE--QAQGKICDQLKKCEKVVEGRNALRQAV 132
+ A E++V+ L KL+Q D LE + + KI L++ ++ +EG L Q
Sbjct: 1009 TLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1068
Query: 133 KI--------LEKRIENLESENKKLKKDIQEEQA-----QRKI-EIEGKLEKSNAFAALE 178
+ L+++++ E E L+ I++EQA Q+KI E++ ++E+ LE
Sbjct: 1069 TMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALAMQLQKKIKELQARIEE------LE 1122
Query: 179 NEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDIL 238
E+ A ++ K +K + + + E E A +A ++E +K+++D+
Sbjct: 1123 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1182
Query: 239 DE--QAQGKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQR 296
+ Q + KK + V E L + + L++ + LE E +LK +I + +
Sbjct: 1183 EATLQHEATAATLRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSELKMEIDDLASNM 1238
Query: 297 KVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALE 356
+ + K + LE++VS LK++ ++ ++ I + AQR E S +
Sbjct: 1239 ETVSKAKGNLEKMCRTLEDQVSELKTKEEEHQRLINDLSAQRARLQTESGEFSRQLDEKD 1298
Query: 357 NEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLES 416
+ VS L + Q I ++LK++ E+ ++ ++AL A +++
Sbjct: 1299 SLVSQLSRGKQAFTQQI----------EELKRQLEEEIKAKSALAHA-------LQSARH 1341
Query: 417 ENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSALKSESTKLKKDILEEQAQIKV 476
+ L++ +EEQ E K E+ A + +EV+ + TK + D ++ +++
Sbjct: 1342 DCDLLREQYEEEQ-------EAKAELQRAMSKANSEVAQWR---TKYETDAIQRTEELE- 1390
Query: 477 AIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNT 536
E K +++ E V A+ ++ A+L++ + +VE L + T
Sbjct: 1391 --EAKKKLAQRLQDAEEHVEAVNAKCASLEKT----KQRLQNEVEDLMIDVERTNAACAA 1444
Query: 537 LKKELVEKEKIVADSERK--TAVDERKKAAAEARKLLEAAKKI--APEKAVIPEPANCCS 592
L K+ +KI+A+ + K E + + E+R L K+ A E+++
Sbjct: 1445 LDKKQRNFDKILAEWKHKYEETHAELEASQKESRSLSTEVFKVKNAYEESL--------D 1496
Query: 593 KCDELKKKCEKVAVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKC 652
+ + LK++ + + + L + + K I LE K++++E KSE+ A ++
Sbjct: 1497 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKVKKQVEQE------KSELQAALEEA 1550
Query: 653 GAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARK 712
A G + ++ ++ K E++R E EE + + + + AE R
Sbjct: 1551 EASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRS 1610
Query: 713 LLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKTKEATKRFEAEKKKLLV 772
+A +I ++E + ++E++ H ++A E + T+ + + L
Sbjct: 1611 RNDA-IRIKKKMEGDLNEMEIQLNHAN--------RMAAEALRNYRNTQGILKDTQLHLD 1661
Query: 773 EKINAESKIKKAQERSESELDKKTADMEK-----QQAEEQKKLAEDKLLLLGDSLQL 824
+ + + +K+ E + A++E+ +Q E +K+AE +LL + +QL
Sbjct: 1662 DALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKVAEQELLDASERVQL 1718
Score = 115 bits (288), Expect = 5e-25
Identities = 197/886 (22%), Positives = 385/886 (43%), Gaps = 121/886 (13%)
Query: 22 KKKCEQVVVG-RNALRQAVKI---LEKGIENLESENKKLKK---DIQEEQAQRKVAIEGK 74
K K EQ V +L Q KI LE+ LE + K ++ DI+ ++ Q ++ K
Sbjct: 1027 KTKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1086
Query: 75 -LEISNTFAALENEVSALISENKKLKQ-----DILEEQAQGKICDQLKK----------- 117
E+SN + +E+E + + KK+K+ + LEE+ + + + K
Sbjct: 1087 EFEMSNLQSKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1146
Query: 118 ---CEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQ--------RKIEIEG 166
E++ E A +++ +KR E+E +K+++D++E Q RK +
Sbjct: 1147 EEISERLEEAGGATSAQIEMNKKR----EAEFQKMRRDLEEATLQHEATAATLRKKHADS 1202
Query: 167 KLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSAL 226
E L+ L+ E +LK +I + + + + K + LE++VS L
Sbjct: 1203 VAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRTLEDQVSEL 1262
Query: 227 KSENKKLKQDILDEQAQ--------GKFCDRLKKKCEKVVE---GRNALRQAVKILEKGI 275
K++ ++ ++ I D AQ G+F +L +K V + G+ A Q ++ L++ +
Sbjct: 1263 KTKEEEHQRLINDLSAQRARLQTESGEFSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQL 1322
Query: 276 ENLESENKKLKKDIQEEH-------AQRKVEIEGKLEISNAFAALENEVSA--LKSENKK 326
E L +Q Q + E E K E+ A + +EV+ K E
Sbjct: 1323 EEEIKAKSALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA 1382
Query: 327 LKKDILEEQAQRKVAM-----EGKLEISNA-FAALENEVSALKSENKKLKQDILEEQAQG 380
+++ E+A++K+A E +E NA A+LE L++E + L D+ A
Sbjct: 1383 IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAA- 1441
Query: 381 KFCDQLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKL 440
C L KK R KIL + E + +L+ Q+E E+
Sbjct: 1442 --CAALDKK----------QRNFDKILAEWKHKYEETHAELEAS-QKESRSLSTEV---F 1485
Query: 441 EISNAFAALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALENEVSALKS 500
++ NA+ +++ LK E+ L+++I + QI + E+ +E E S L++
Sbjct: 1486 KVKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKVKKQVEQEKSELQA 1545
Query: 501 EI----AALQQKCGAGSR---EGNGDVEVLKAGISDTEKEVNTLKKE---LVEKEKIVAD 550
+ A+L+ + G R E N + I++ ++E++ LK+ +VE + D
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLD 1605
Query: 551 SE---RKTAVDERKKAAAEARKL---LEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKV 604
+E R A+ +KK + ++ L A ++A E + N + + +
Sbjct: 1606 AEIRSRNDAIRIKKKMEGDLNEMEIQLNHANRMAAE--ALRNYRNTQGILKDTQLHLDDA 1663
Query: 605 AVGRNALRQAVKILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVE 664
G+ L++ + ++E+ L++E ++L+ E + ++ A Q+ A R V+
Sbjct: 1664 LRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKV-AEQELLDASER-----VQ 1717
Query: 665 VLKAGISDTKKEVNRLKKEHVEEERIVADSERKTAVDERKNAAAEARKLLEAPKKIAAEV 724
+L + +N KK + +I E + V E +NA +A+K + +A E+
Sbjct: 1718 LLH---TQNTSLINTKKKLETDISQI--QGEMEDIVQEARNAEEKAKKAITDAAMMAEEL 1772
Query: 725 EKQ---IAKVELRQVHLEKQVNERKMKL----AFELSKTKEATKRFEAEKKKLLVEKINA 777
+K+ A +E + ++E+ V + + +L L K+ ++ EA ++L E + +
Sbjct: 1773 KKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEAE-VES 1831
Query: 778 ESKIKKAQERSESELDKKTADMEKQQAEEQKKLAEDKLLLLGDSLQ 823
E K + + +++ ++ Q E++K + +L L D LQ
Sbjct: 1832 EQKRNVEAVKGLRKHERRVKELTYQTEEDRKNVL--RLQDLVDKLQ 1875
Score = 93.2 bits (230), Expect = 2e-18
Identities = 159/739 (21%), Positives = 308/739 (41%), Gaps = 103/739 (13%)
Query: 35 LRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEISNTFAALENEVSALIS- 93
L + + L++ + LE E +LK +I + + + + K + LE++VS L +
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRTLEDQVSELKTK 1265
Query: 94 --ENKKLKQDILEEQAQ-----GKICDQLKKCEKVVE----GRNALRQAVKILEKRIENL 142
E+++L D+ ++A+ G+ QL + + +V G+ A Q ++ L++++E
Sbjct: 1266 EEEHQRLINDLSAQRARLQTESGEFSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQLEEE 1325
Query: 143 ESENKKLKKDIQEEQAQRKIEIEGKLEKSNAFAALENEVSALKSE----NKKLKKDILE- 197
L +Q + + E E+ A A L+ +S SE K + D ++
Sbjct: 1326 IKAKSALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1385
Query: 198 ----EQAQRKVAM-----EGKLEISNA-FAALENEVSALKSENKKLKQDILDEQAQGKFC 247
E+A++K+A E +E NA A+LE L++E + L D+ A
Sbjct: 1386 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1445
Query: 248 DRLKKKCEKVV-------------------EGRNALRQAVKI---LEKGIENLES---EN 282
D+ ++ +K++ E R+ + K+ E+ ++ LE+ EN
Sbjct: 1446 DKKQRNFDKILAEWKHKYEETHAELEASQKESRSLSTEVFKVKNAYEESLDQLETLKREN 1505
Query: 283 KKLKKDIQEE-----------HAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDI 331
K L+++I + H KV+ + + E S AALE ++L+ E K+ +
Sbjct: 1506 KNLQQEISDLTEQIAEGGKRIHELEKVKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1565
Query: 332 LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKL---KQDILEEQAQGKF-CDQLK 387
LE + K EI A + E+ LK + ++ Q L+ + + + ++K
Sbjct: 1566 LELN-------QVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIK 1618
Query: 388 KKCE-KVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKIEIEGKLEISNAF 446
KK E + E L A ++ + + N + LK + Q + G+ ++
Sbjct: 1619 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK----DTQLHLDDALRGQEDLKEQL 1674
Query: 447 AALENEVSALKSESTKLKKDILEEQAQIKVAIEEKLEISNAFAALE-------NEVSALK 499
A +E + L++E +L+ + + + KVA +E L+ S L N L+
Sbjct: 1675 AMVERRANLLQAEIEELRATLEQTERSRKVAEQELLDASERVQLLHTQNTSLINTKKKLE 1734
Query: 500 SEIAALQQKCGAGSREGNGDVEVLKAGISDTEKEVNTLKKE---LVEKEKIVADSERKTA 556
++I+ +Q + +E E K I+D LKKE E++ + E+
Sbjct: 1735 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1794
Query: 557 VDERKKAAAEARKLLEAAKKIAPEKAVIPEPANCCSKCDELKKKCEKVAVGRNALRQAVK 616
+ + AE L K+I +A + E E K+ E V + ++
Sbjct: 1795 DLQHRLDEAEQLALKGGKKQIQKLEARVRELE--AEVESEQKRNVEAV--------KGLR 1844
Query: 617 ILEKGIENLESENKKLKKENEVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKE 676
E+ ++ L + ++ +K V L+ + LQ K + R+ E +S +K
Sbjct: 1845 KHERRVKELTYQTEEDRK--NVLRLQDLVDKLQAKVKSYKRQAEEAEEQCNINLSKFRKL 1902
Query: 677 VNRLKKEHVEEERIVADSE 695
+ L E EE +A+S+
Sbjct: 1903 QHEL--EEAEERADIAESQ 1919
Score = 91.7 bits (226), Expect = 7e-18
Identities = 117/484 (24%), Positives = 228/484 (46%), Gaps = 47/484 (9%)
Query: 353 AALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEGRNALRQAVKILEKGIE 412
A E E++ +K E +K K+ + + +A+ K +L++K +++ +N L+ V+ +
Sbjct: 846 AETEKEMANMKEEFEKTKESLAKAEAKEK---ELEEKMVALMQEKNDLQLQVQAEADSLA 902
Query: 413 NLESENKKLKKDIQEEQAQRKIEIEGKLEISNAFAALENEVSA--------LKSESTKLK 464
+ E +L K KI++E K++ A E E++A L+ E ++LK
Sbjct: 903 DAEERCDQLIKT--------KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 954
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQKCGAGSREGNGDVEVLK 524
KDI + + + +EK A EN+V L E+A L + ++E E +
Sbjct: 955 KDIDDLELTLAKVEKEK-------HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1007
Query: 525 AGISDTEKE---VNTLKKELVEKEKIVADSERKTAVDERKKAAAE-ARKLLEAAKKIAPE 580
+ D + E VNTL K + E+ V D E +++ + E A++ LE K+A E
Sbjct: 1008 QTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1067
Query: 581 KAVIPEPANCCSKCDE-LKKKCEKVAVGRNAL--RQAVKI-LEKGIENLESENKKLKKEN 636
+ E N + DE LKKK +++ ++ + QA+ + L+K I+ L++ ++L E
Sbjct: 1068 STMDIE--NDKQQLDEKLKKKEFEMSNLQSKIEDEQALAMQLQKKIKELQARIEEL--EE 1123
Query: 637 EVSALKSEISALQQKCGAGAREGNGDVEVLKAGISDTKKEVNRLKKEHVEEERIVADSER 696
E+ A ++ + +++ +RE E L+ T ++ KK E +++ D E
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1183
Query: 697 KTAVDERKNAAAEARKLLEAPKKIAAEVEKQIAKVELRQVHLEKQVNERKMKLAFELSKT 756
T E A A L + AE+ +QI ++ + LEK+ +E KM++ +L+
Sbjct: 1184 ATLQHE-----ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEID-DLASN 1237
Query: 757 KEATKRFEAEKKKLLVEKINAESKIKKAQERSE---SELDKKTADMEKQQAEEQKKLAED 813
E + + +K+ + S++K +E + ++L + A ++ + E ++L E
Sbjct: 1238 METVSKAKGNLEKMCRTLEDQVSELKTKEEEHQRLINDLSAQRARLQTESGEFSRQLDEK 1297
Query: 814 KLLL 817
L+
Sbjct: 1298 DSLV 1301
Score = 91.3 bits (225), Expect = 9e-18
Identities = 111/524 (21%), Positives = 230/524 (43%), Gaps = 53/524 (10%)
Query: 19 EELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQRKVAIEGKLEIS 78
+ L+ + E +++ A L+K N + + K +E A+ + + + +S
Sbjct: 1422 QRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKHKYEETHAELEASQKESRSLS 1481
Query: 79 NTFAALEN-------EVSALISENKKLKQDILEEQAQ----GKICDQLKKCEKVVEGRNA 127
++N ++ L ENK L+Q+I + Q GK +L+K +K VE +
Sbjct: 1482 TEVFKVKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKVKKQVEQEKS 1541
Query: 128 LRQAVKILEKRIENLESENKKLKKDIQEEQAQRKIEIEGKL-EKSNAFAALE-NEVSALK 185
QA LE+ +LE E K+ + IQ E Q K EI+ K+ EK L+ N + ++
Sbjct: 1542 ELQAA--LEEAEASLEHEEGKILR-IQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVE 1598
Query: 186 SENKKLKKDI--LEEQAQRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILDEQAQ 243
S L +I + + K MEG L N ++A N + Q IL +
Sbjct: 1599 SMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKD--- 1655
Query: 244 GKFCDRLKKKCEKVVEGRNALRQAVKILEKGIENLESENKKLKKDIQEEHAQRKVEIEGK 303
+ + + G+ L++ + ++E+ L++E ++L+ +++ RKV +
Sbjct: 1656 ------TQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKVAEQEL 1709
Query: 304 LEISNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALENEVSALK 363
L+ S L + ++L + KKL+ DI + Q + + ++ E NA E +
Sbjct: 1710 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ---EARNA----EEKAKKAI 1762
Query: 364 SENKKLKQDILEEQAQGKFCDQLKKKCEKVVEG-RNALRQAVKILEKG----IENLESEN 418
++ + +++ +EQ +++KK E+ V+ ++ L +A ++ KG I+ LE+
Sbjct: 1763 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822
Query: 419 KKLKKDIQEEQAQRKIEIEG--------------KLEISNAFAALENEVSALKSESTKLK 464
++L+ +++ EQ + ++G E L++ V L+++ K
Sbjct: 1823 RELEAEVESEQKRNVEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882
Query: 465 KDILEEQAQIKVAIEEKLEISNAFAALENEVSALKSEIAALQQK 508
+ E + Q + + + ++ + E +S++ L+ K
Sbjct: 1883 RQAEEAEEQCNINLSKFRKLQHELEEAEERADIAESQVNKLRVK 1926
Score = 70.1 bits (170), Expect = 2e-11
Identities = 89/453 (19%), Positives = 200/453 (43%), Gaps = 79/453 (17%)
Query: 17 KCEELKKKCEQVVVGRNALRQAVKILEKGIENLESENKKLKKDIQEEQAQ--RKVAIEGK 74
+ EL+K +QV ++ L+ A++ E +E+ E + +++ ++ + +++ RK+A E
Sbjct: 1525 RIHELEKVKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIA-EKD 1583
Query: 75 LEIS----NTFAALENEVSALISE----------NKKLKQDILEEQ-------------- 106
EI N +E+ S L +E KK++ D+ E +
Sbjct: 1584 EEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHANRMAAEAL 1643
Query: 107 -----AQGKICDQLKKCEKVVEGRNALRQAVKILEKRIENLESENKKLKKDIQEEQAQRK 161
QG + D + + G+ L++ + ++E+R L++E ++L+ +++ + RK
Sbjct: 1644 RNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1703
Query: 162 IEIEGKLEKSNAFAALENEVSALKSENKKLKKDILEEQAQRKVAMEGKLEISNAFAALEN 221
+ + L+ S L + ++L + KKL+ DI + Q + + ++ E NA E
Sbjct: 1704 VAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQ---EARNA----EE 1756
Query: 222 EVSALKSENKKLKQDILDEQAQGKFCDRLKKKCEKVVEG-RNALRQAVKILEKG----IE 276
+ ++ + +++ EQ +R+KK E+ V+ ++ L +A ++ KG I+
Sbjct: 1757 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQ 1816
Query: 277 NLESENKKLKKDIQEEHAQRKVEIEGKLEISNAFAALENEVSALKSENKKLKKDILEEQA 336
LE+ ++L+ +++ E +R VE V L+ +++K+ + +
Sbjct: 1817 KLEARVRELEAEVESEQ-KRNVE----------------AVKGLRKHERRVKELTYQTEE 1859
Query: 337 QRKVAMEGKLEISNAFAALENEVSALKSENKKLKQDILEEQAQGKFCDQLKKKCEKVVEG 396
RK + L++ V L+++ K K+ E + Q C+ K K+
Sbjct: 1860 DRKNVLR-----------LQDLVDKLQAKVKSYKRQAEEAEEQ---CNINLSKFRKLQHE 1905
Query: 397 RNALRQAVKILEKGIENLESENKKLKKDIQEEQ 429
+ I E + L +++++ + E+
Sbjct: 1906 LEEAEERADIAESQVNKLRVKSREVHTKVISEE 1938
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.305 0.124 0.307
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,115,835
Number of Sequences: 164201
Number of extensions: 3488045
Number of successful extensions: 37309
Number of sequences better than 10.0: 2269
Number of HSP's better than 10.0 without gapping: 335
Number of HSP's successfully gapped in prelim test: 1964
Number of HSP's that attempted gapping in prelim test: 19665
Number of HSP's gapped (non-prelim): 9187
length of query: 824
length of database: 59,974,054
effective HSP length: 119
effective length of query: 705
effective length of database: 40,434,135
effective search space: 28506065175
effective search space used: 28506065175
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 70 (31.6 bits)
Lotus: description of TM0437b.7