BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0346.8
         (1441 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin             478  e-134
BFR1_SCHPO (P41820) Brefeldin A resistance protein                    464  e-130
YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W        461  e-129
CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom...   458  e-128
PDRF_YEAST (Q04182) ATP-dependent permease PDR15                      453  e-126
SNQ2_YEAST (P32568) SNQ2 protein                                      440  e-122
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3              439  e-122
CDR2_CANAL (P78595) Multidrug resistance protein CDR2                 435  e-121
PDRA_YEAST (P51533) ATP-dependent permease PDR10                      435  e-121
PDRC_YEAST (Q02785) ATP-dependent permease PDR12                      427  e-118
CDR1_CANAL (P43071) Multidrug resistance protein CDR1                 427  e-118
CDR4_CANAL (O74676) ABC transporter CDR4                              417  e-116
AUS1_YEAST (Q08409) ATP-dependent permease AUS1                       321  8e-87
PDRB_YEAST (P40550) ATP-dependent permease PDR11                      301  1e-80
YOH5_YEAST (Q08234) Probable ATP-dependent transporter YOL074C/Y...   277  1e-73
WHIT_DROME (P10090) White protein                                     214  1e-54
WHIT_LUCCU (Q05360) White protein                                     214  2e-54
WHIT_CERCA (Q17320) White protein                                     213  2e-54
ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1...   211  9e-54
ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2...   208  1e-52

>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
          Length = 1511

 Score =  478 bits (1231), Expect = e-134
 Identities = 358/1291 (27%), Positives = 606/1291 (46%), Gaps = 133/1291 (10%)

Query: 173  HSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDS-NLKKTGSITYNGHEADE 231
            ++  IL  + G + PG + ++LG PG+G ++LL +++      +L     I+Y+G+  D+
Sbjct: 171  NTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNTHGFDLGADTKISYSGYSGDD 230

Query: 232  F--FVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPS 289
                 +    Y ++ D H   LTV ETL   AR +  Q         I  ++ E      
Sbjct: 231  IKKHFRGEVVYNAEADVHLPHLTVFETLVTVARLKTPQNR-------IKGVDRESYANHL 283

Query: 290  PEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMI 349
             E+     A +  G  H+ NT                VG+D++RGVSGG+RKRV+  E+ 
Sbjct: 284  AEV-----AMATYGLSHTRNTK---------------VGNDIVRGVSGGERKRVSIAEVS 323

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
            +   K    D  + GLDS+T  + ++ +K    + + +  +A+ Q + + ++LF+ + +L
Sbjct: 324  ICGSKFQCWDNATRGLDSATALEFIRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVL 383

Query: 410  SEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSR------------------- 450
             +G+ IY GP +   ++FE +G+  P R+  ADFL  V+S                    
Sbjct: 384  DDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLTSVTSPSERTLNKDMLKKGIHIPQT 443

Query: 451  -KDQAQYWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYA 509
             K+   YW       + +   E+ +   N    S     + H   +SK    A   + Y 
Sbjct: 444  PKEMNDYWVKSPNYKELMK--EVDQRLLNDDEASREAIKEAHIAKQSK---RARPSSPYT 498

Query: 510  VSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYV 569
            VS     K    R    +       +F       +  +  ++F +  M   D +      
Sbjct: 499  VSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSMFFKI-MKKGDTSTFYFRG 557

Query: 570  SALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVI 629
            SA+FF ++   F+   E+  +    P+  K R    Y   A +  + +  +P  +I AV 
Sbjct: 558  SAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVLSEIPSKLIIAVC 617

Query: 630  WTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVI 689
            + +I Y+ V F  + G FF Y+ I  V       LFR + S+ + +  A    S  LL +
Sbjct: 618  FNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSHLFRCVGSLTKTLSEAMVPASMLLLAL 677

Query: 690  FLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMKQSALGNNTIGYNILH 749
             +  GF IPK  I  W  W ++++PL Y   ++ +NEF   ++     +       NI  
Sbjct: 678  SMYTGFAIPKKKILRWSKWIWYINPLAYLFESLLINEFHGIKFPCAEYVPRGPAYANISS 737

Query: 750  AQSL-------PSEDY------------WY----WVSVAVLVTYAIIFNIMVTLALAYLH 786
             +S+       P +DY            +Y    W    + + Y + F  +      Y  
Sbjct: 738  TESVCTVVGAVPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMAYVVFFFFVYLFLCEYNE 797

Query: 787  PLQK-------PRTVIPQ-----------DDEPEKSSSRD---ANYVFSTRSTKDESNTK 825
              ++       PR+++ +            ++PE    R    ++      S+++ES+T 
Sbjct: 798  GAKQKGEILVFPRSIVKRMKKRGVLTEKNANDPENVGERSDLSSDRKMLQESSEEESDTY 857

Query: 826  GMI-LPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSG 884
            G I L        + N+ Y V +  E R+         +L+NV G   PG LTAL+G+SG
Sbjct: 858  GEIGLSKSEAIFHWRNLCYEVQIKAETRR---------ILNNVDGWVKPGTLTALMGASG 908

Query: 885  AGKTTLMDVLAGRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWF 944
            AGKTTL+D LA R T G I GDI ++G P++ ++F R  GY +Q D+H    T+ ESL F
Sbjct: 909  AGKTTLLDCLAERVTMGVITGDILVNGIPRD-KSFPRSIGYCQQQDLHLKTATVRESLRF 967

Query: 945  SASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVA 1004
            SA LR P E+S ++K  +VE+V+K++E++   +A+VG+ G  GL+ EQRKRLTI VEL A
Sbjct: 968  SAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGE-GLNVEQRKRLTIGVELTA 1026

Query: 1005 NPSI-IFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKR 1063
             P + +F+DEPTSGLD++ A  + + ++   + G+ ++CTIHQPS  + + FD LL M+R
Sbjct: 1027 KPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQR 1086

Query: 1064 GGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIY 1123
            GG+ +Y G LG   + MIDYF+   G    P   NPA W+LEV   +     + D+ E++
Sbjct: 1087 GGKTVYFGDLGEGCKTMIDYFES-HGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEVW 1145

Query: 1124 NNSDQYRGVEASI--LEFEHPPAGSEPLKFDT-IYSQSLLSQFYRCLWKQNLVYWRSPPY 1180
             NS++YR V++ +  +E E P  GS     D   +SQS++ Q      +    YWRSP Y
Sbjct: 1146 RNSEEYRAVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIRLFQQYWRSPDY 1205

Query: 1181 NAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVS- 1239
               +   T  + L  G  F+  G+     Q        + A  +F  + N    Q + S 
Sbjct: 1206 LWSKFILTIFNQLFIGFTFFKAGTSLQGLQ------NQMLAVFMFTVIFNPILQQYLPSF 1259

Query: 1240 IERTVFY--REKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAG---- 1293
            +++   Y  RE+ +  +S I++  AQ  +E+P+  +   +   I Y+ I F   A     
Sbjct: 1260 VQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYFIYYYPIGFYSNASAAGQ 1319

Query: 1294 ---KFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHI 1350
               +  L+ LF    + Y    G++ +  +     AA ++S  +++     G +   S +
Sbjct: 1320 LHERGALFWLFSCAFYVYVGSMGLLVISFNQVAESAANLASLLFTMSLSFCGVMTTPSAM 1379

Query: 1351 PGWWIWFYYICPVQWTLRGVITSQLGDVETK 1381
            P +WI+ Y + P+ + ++ ++   + +V+ K
Sbjct: 1380 PRFWIFMYRVSPLTYFIQALLAVGVANVDVK 1410



 Score =  148 bits (373), Expect = 1e-34
 Identities = 160/668 (23%), Positives = 274/668 (40%), Gaps = 99/668 (14%)

Query: 842  SYFVDMPQEIRKQGIPETR-------LQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVL 894
            S  V++P +I K G+ + +        Q+L  + G  +PG L  ++G  G+G TTL+  +
Sbjct: 147  STVVNIPYKILKSGLRKFQRSKETNTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSI 206

Query: 895  AGRKTGGYIEGDIKIS--GYPKE--QRTFARISGYVEQNDIHSPQVTIEESLWFSASLRL 950
            +    G  +  D KIS  GY  +  ++ F     Y  + D+H P +T+ E+L   A L+ 
Sbjct: 207  SSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADVHLPHLTVFETLVTVARLKT 266

Query: 951  PKEISTDKKRE-----FVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVAN 1005
            P+       RE       E  M    L   RN  VG     G+S  +RKR++IA   +  
Sbjct: 267  PQNRIKGVDRESYANHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICG 326

Query: 1006 PSIIFMDEPTSGLDARAAAIVMRAVRNTVDTGRT-VVCTIHQPSIDIFEAFDDLLLMKRG 1064
                  D  T GLD+  A   +RA++   D   T     I+Q S D ++ F+ + ++  G
Sbjct: 327  SKFQCWDNATRGLDSATALEFIRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVLDDG 386

Query: 1065 GRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDAD------ 1118
             ++ YG      +     YF+ +  +   P     A ++  VT+PS E T++ D      
Sbjct: 387  YQIYYG-----PADKAKKYFEDMGYV--CPSRQTTADFLTSVTSPS-ERTLNKDMLKKGI 438

Query: 1119 ------------------FAEIYNNSDQ--YRGVEAS--ILEFEHPPAGSEPLKFDTIYS 1156
                              + E+    DQ      EAS   ++  H    S+  +  + Y+
Sbjct: 439  HIPQTPKEMNDYWVKSPNYKELMKEVDQRLLNDDEASREAIKEAHIAKQSKRARPSSPYT 498

Query: 1157 QSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVM 1216
             S + Q    L +       +  +    +      AL+ G++F+ I  K+  T   Y   
Sbjct: 499  VSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSMFFKI-MKKGDTSTFYFRG 557

Query: 1217 GALYASCLFIGVNNASTVQPIVSI--ERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQ 1274
             A++ + LF   N  S++  I S+   R +  + +   +Y P A A A  L EIP   + 
Sbjct: 558  SAMFFAILF---NAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVLSEIPSKLII 614

Query: 1275 AMVFGLITYFMINFERTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFY 1334
            A+ F +I YF+++F R  G FF YLL   +     +        L+ T   A V +S   
Sbjct: 615  AVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSHLFRCVGSLTKTLSEAMVPASMLL 674

Query: 1335 SLWNLLSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDV---------------- 1378
               ++ +GF IP+  I  W  W +YI P+ +    ++ ++   +                
Sbjct: 675  LALSMYTGFAIPKKKILRWSKWIWYINPLAYLFESLLINEFHGIKFPCAEYVPRGPAYAN 734

Query: 1379 ----------------ETKIIGPGF-EGTVKEYLSLNLGYDPKIMGISTVGLSVIVLFGF 1421
                            +  ++G  F  GT + Y      +  K  G   +G++ +V F F
Sbjct: 735  ISSTESVCTVVGAVPGQDYVLGDDFIRGTYQYY------HKDKWRGFG-IGMAYVVFFFF 787

Query: 1422 IILFFCSF 1429
            + LF C +
Sbjct: 788  VYLFLCEY 795



 Score =  125 bits (313), Expect = 1e-27
 Identities = 152/586 (25%), Positives = 258/586 (43%), Gaps = 101/586 (17%)

Query: 171  KRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEAD 230
            K  +  IL+NV G +KPG +T L+GA GAGK++LL  LA ++   +  TG I  NG   D
Sbjct: 881  KAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGV-ITGDILVNGIPRD 939

Query: 231  EFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSP 290
            + F  R+  Y  Q D H    TVRE+L F+A                        +R   
Sbjct: 940  KSF-PRSIGYCQQQDLHLKTATVRESLRFSA-----------------------YLRQPA 975

Query: 291  EIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMI 349
            E+       S+  K   V  + ++K+L ++  ++ +VG     G++  QRKR+T G E+ 
Sbjct: 976  EV-------SIEEKNRYV--EEVIKILEMEKYADAVVGV-AGEGLNVEQRKRLTIGVELT 1025

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
              P+  +F+DE ++GLDS T + I + +K   +   A +L  + QP+    + FD L+ +
Sbjct: 1026 AKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQA-ILCTIHQPSAILMQEFDRLLFM 1084

Query: 410  SE-GHVIYEGPR----ENVLEFFESIG-FKLPPRKGIADFLQEV-------SSRKDQAQY 456
               G  +Y G      + ++++FES G  K P     A+++ EV        + +D  + 
Sbjct: 1085 QRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEV 1144

Query: 457  WADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEIS 516
            W + S++Y+ V S          + GS   +   H + +S  + + L   +     W   
Sbjct: 1145 WRN-SEEYRAVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIRLFQQYWRSP 1203

Query: 517  KACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGL 576
               +++  L I  Q            F+GF   T F   +   + +   N  ++   F +
Sbjct: 1204 DYLWSKFILTIFNQ-----------LFIGF---TFF---KAGTSLQGLQNQMLAVFMFTV 1246

Query: 577  VHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLT-NWV--------LRVPYSIIEA 627
            +   FN      ++   LP F +QRD L+      S T +W+        + VP++I+  
Sbjct: 1247 I---FN-----PILQQYLPSFVQQRD-LYEARERPSRTFSWISFIFAQIFVEVPWNILAG 1297

Query: 628  VIWTVIVYYTVGFAPSA---------GRFFRYMFILFVMHQMAIGLFRMMASIARDMVLA 678
             I   I YY +GF  +A         G  F      F ++  ++GL      I+ + V  
Sbjct: 1298 TIAYFIYYYPIGFYSNASAAGQLHERGALFWLFSCAFYVYVGSMGLL----VISFNQVAE 1353

Query: 679  NTFGSAALLVIFLLG--GFIIPKGMIKPWWIWGYWLSPLTYGQRAI 722
            +    A+LL    L   G +     +  +WI+ Y +SPLTY  +A+
Sbjct: 1354 SAANLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQAL 1399


>BFR1_SCHPO (P41820) Brefeldin A resistance protein
          Length = 1530

 Score =  464 bits (1194), Expect = e-130
 Identities = 353/1328 (26%), Positives = 604/1328 (44%), Gaps = 167/1328 (12%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEADEF--FV 234
            IL +   +   G + ++LG PG+G S+ L ++        +  G+  Y+G +  +   F 
Sbjct: 176  ILSHCHALANAGELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKKFF 235

Query: 235  KRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDA 294
                 Y  + D H   LT  ETLDFAA+C               R  N R          
Sbjct: 236  PGDLLYSGENDVHFPSLTTAETLDFAAKC---------------RTPNNRPCN------- 273

Query: 295  FMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPRK 354
              +   V  ++H + T +     GL     T VG+D +RGVSGG+RKRVT  E       
Sbjct: 274  LTRQEYVSRERHLIATAF-----GLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPT 328

Query: 355  TLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHV 414
                D  + GLDSST F+ V  ++   + +  T  +   Q + + ++LFD + +L  G  
Sbjct: 329  IACWDNSTRGLDSSTAFEFVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQ 388

Query: 415  IYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQ-----------------AQYW 457
            IY GP +   ++F  +GF   PR+   DFL  +S  K +                  Q W
Sbjct: 389  IYYGPADKAKQYFLDMGFDCHPRETTPDFLTAISDPKARFPRKGFENRVPRTPDEFEQMW 448

Query: 458  ADPSKQYQFVPSGEI------------AEAFRNSRFGSYVESLQTHPYDKSKCHPSALAR 505
             + S     +   E             +EA     FGS + +   H   +         R
Sbjct: 449  RNSSVYADLMAEMESYDKRWTETTPASSEAPEKDNFGSDISATTKHELYRQSAVAEKSKR 508

Query: 506  TK----YAVSRWEISKACFAR-------EALLISRQRFLYIFKTCQVAFVGFVTCTIFLR 554
             K    Y V+  +    C AR       +   I    F ++F++  +        +IF  
Sbjct: 509  VKDTSPYTVTFSQQLWYCLARSWERYINDPAYIGSMAFAFLFQSLIIG-------SIFYD 561

Query: 555  TRMHPTDEAYGNLYVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLT 614
             +++  D          LFF ++       SE++ M ++ P+  K R +  Y   A  ++
Sbjct: 562  MKLNTVDVFSRG---GVLFFSILFCALQSLSEIANMFSQRPIIAKHRASALYHPAADVIS 618

Query: 615  NWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARD 674
            + ++ +P+  I   ++++++Y+      +AG F+ Y   LF+        FR +A I  +
Sbjct: 619  SLIVDLPFRFINISVFSIVLYFLTNLKRTAGGFWTYFLFLFIGATCMSAFFRSLAGIMPN 678

Query: 675  MVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMK 734
            +  A+  G   +L I +  G+ IP   +  W+ W  +L PL +G  ++ +NEF A ++  
Sbjct: 679  VESASALGGIGVLAIAIYTGYAIPNIDVGWWFRWIAYLDPLQFGFESLMINEFKARQFEC 738

Query: 735  QSAL--GNNTIGYNILH-----AQSLPSEDY----------------WYWVSVAVLVTY- 770
               +  G+    Y + +       + P  DY                  W ++A+++ Y 
Sbjct: 739  SQLIPYGSGYDNYPVANKICPVTSAEPGTDYVDGSTYLYISFNYKTRQLWRNLAIIIGYY 798

Query: 771  --AIIFNIMVTLAL-------AYL-----HPLQKPRTVIPQDDEP----EKSSSRDANYV 812
               +  NI+ +  L        YL     H     +  + +  +P        ++  + V
Sbjct: 799  AFLVFVNIVASETLNFNDLKGEYLVFRRGHAPDAVKAAVNEGGKPLDLETGQDTQGGDVV 858

Query: 813  FSTRSTKDESNTKGMILPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFS 872
              +   ++E N +   +       ++ N++Y + +  E R+         LL+ V G   
Sbjct: 859  KESPDNEEELNKEYEGIEKGHDIFSWRNLNYDIQIKGEHRR---------LLNGVQGFVV 909

Query: 873  PGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIH 932
            PG LTAL+G SGAGKTTL++VLA R   G + GD+ ++G   +  TF R +GYV+Q D+H
Sbjct: 910  PGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGLDS-TFQRRTGYVQQQDVH 968

Query: 933  SPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQ 992
              + T+ E+L FSA+LR P  +   +K E+VE V+KL+E++S   A++G PGS GL+ EQ
Sbjct: 969  IGESTVREALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGS-GLNVEQ 1027

Query: 993  RKRLTIAVELVANPSII-FMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDI 1051
            RKR TI VEL A P+++ F+DEPTSGLD+++A  ++  +R   D G+ ++CTIHQPS  +
Sbjct: 1028 RKRATIGVELAAKPALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAVL 1087

Query: 1052 FEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSV 1111
            F+ FD LLL+++GG+ +Y G +G  S+ +++YF+   G    P   NPA ++L+V     
Sbjct: 1088 FDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNYFES-HGAVHCPDDGNPAEYILDVIGAGA 1146

Query: 1112 EETIDADFAEIYNNSDQYRGVEASILEFEHPPAGSEPLKF-----DTIYSQSLLSQFYRC 1166
              T + D+ E++NNS++ + + A + +     + SE  K       + Y+  L  Q    
Sbjct: 1147 TATTNRDWHEVWNNSEERKAISAELDKINASFSNSEDKKTLSKEDRSTYAMPLWFQVKMV 1206

Query: 1167 LWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWD--IGSKRSSTQELYVVMGALYASCL 1224
            + +    YWR P     ++     + L  G  F++  +G +    +   V M  + A  L
Sbjct: 1207 MTRNFQSYWREPSILMSKLALDIFAGLFIGFTFYNQGLGVQNIQNKLFAVFMATVLAVPL 1266

Query: 1225 FIGVNNASTVQPIVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITY 1283
              G      +QP     R VF  REK + +YS +A+  +  ++EIP+  V   +F L  +
Sbjct: 1267 ING------LQPKFIELRNVFEVREKPSNIYSWVAFVFSAIIVEIPFNLVFGTLFFLCWF 1320

Query: 1284 FMINF--------ERTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYS 1335
            + I F        ++T   + LY+ F      YF+ +G       P    A+V++S  ++
Sbjct: 1321 YPIKFYKHIHHPGDKTGYAWLLYMFFQM----YFSTFGQAVASACPNAQTASVVNSLLFT 1376

Query: 1336 LWNLLSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDV-------ETKIIGPGFE 1388
                 +G L P S++ G+W W + + P  + + G+++  +  +       E   I P   
Sbjct: 1377 FVITFNGVLQPNSNLVGFWHWMHSLTPFTYLIEGLLSDLVHGLPVECKSHEMLTINPPSG 1436

Query: 1389 GTVKEYLS 1396
             T  EY+S
Sbjct: 1437 QTCGEYMS 1444



 Score =  134 bits (337), Expect = 2e-30
 Identities = 156/676 (23%), Positives = 277/676 (40%), Gaps = 115/676 (17%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEADEFFVKR 236
            +L+ V G + PG++T L+G  GAGK++LL  LA ++D+ +  TG +  NG   D  F +R
Sbjct: 900  LLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGVV-TGDMLVNGRGLDSTFQRR 958

Query: 237  TCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFM 296
            T  Y+ Q D H  E TVRE L F+A                                A  
Sbjct: 959  T-GYVQQQDVHIGESTVREALRFSA--------------------------------ALR 985

Query: 297  KASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMIVGPRKT 355
            + +SV   +     + ++K+L ++  +E I+G+    G++  QRKR T G E+   P   
Sbjct: 986  QPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPG-SGLNVEQRKRATIGVELAAKPALL 1044

Query: 356  LFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSE-GHV 414
            LF+DE ++GLDS + + IV  ++       A +L  + QP+   F+ FD L+LL + G  
Sbjct: 1045 LFLDEPTSGLDSQSAWSIVCFLRKLADAGQA-ILCTIHQPSAVLFDQFDRLLLLQKGGKT 1103

Query: 415  IYEGP----RENVLEFFESIGFKLPPRKG-IADFLQEV-------SSRKDQAQYWADPSK 462
            +Y G      + +L +FES G    P  G  A+++ +V       ++ +D  + W +  +
Sbjct: 1104 VYFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDVIGAGATATTNRDWHEVWNNSEE 1163

Query: 463  QYQF-VPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEISKACFA 521
            +        +I  +F NS               + K   S   R+ YA+  W   K    
Sbjct: 1164 RKAISAELDKINASFSNS---------------EDKKTLSKEDRSTYAMPLWFQVKMVMT 1208

Query: 522  REALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMF 581
            R      R+  + + K     F G      F    +         L+   +   L   + 
Sbjct: 1209 RNFQSYWREPSILMSKLALDIFAGLFIGFTFYNQGL-GVQNIQNKLFAVFMATVLAVPLI 1267

Query: 582  NGFSELSLMIARLPVFYKQRDNLFYPAW-AWSLTNWVLRVPYSIIEAVIWTVIVYYTVGF 640
            NG     + +  +    ++  N++  +W A+  +  ++ +P++++   ++ +  +Y + F
Sbjct: 1268 NGLQPKFIELRNVFEVREKPSNIY--SWVAFVFSAIIVEIPFNLVFGTLFFLCWFYPIKF 1325

Query: 641  ---APSAGRFFRYMFILFVMHQMAIGLF-RMMASIARDMVLANTFGSAALLVIFLLGGFI 696
                   G    Y ++L++  QM    F + +AS   +   A+   S     +    G +
Sbjct: 1326 YKHIHHPGDKTGYAWLLYMFFQMYFSTFGQAVASACPNAQTASVVNSLLFTFVITFNGVL 1385

Query: 697  IPKGMIKPWWIWGYWLSPLTY------------------GQRAITVNE---FTASRWMKQ 735
             P   +  +W W + L+P TY                      +T+N     T   +M  
Sbjct: 1386 QPNSNLVGFWHWMHSLTPFTYLIEGLLSDLVHGLPVECKSHEMLTINPPSGQTCGEYM-S 1444

Query: 736  SALGNNTIGYNILHAQSLPSEDY------------------WYWVSVAVLVTYAIIFNIM 777
            + L NNT   N+L+  +  S  Y                    W ++ + V Y + FNI 
Sbjct: 1445 AFLTNNTAAGNLLNPNATTSCSYCPYQTADQFLERFSMRYTHRWRNLGIFVGY-VFFNIF 1503

Query: 778  VTLALAYLHPLQKPRT 793
              L L Y+  + K R+
Sbjct: 1504 AVLLLFYVFRVMKLRS 1519


>YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W
          Length = 1333

 Score =  461 bits (1186), Expect = e-129
 Identities = 349/1263 (27%), Positives = 584/1263 (45%), Gaps = 122/1263 (9%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLD--SNLKKTGSITYNGHEADEFF- 233
            IL NVS + K G M L+LG PGAG +S L + AG+    +    TG I+Y+G    E   
Sbjct: 45   ILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHISYDGIPQKEMMQ 104

Query: 234  -VKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEI 292
              K    Y  + D H   LTV++TLDFA  C+                       P+  +
Sbjct: 105  HYKPDVIYNGEQDVHFPHLTVKQTLDFAISCK----------------------MPAKRV 142

Query: 293  DAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGP 352
            +   K   +     + N ++  K+ GL    +T VG+D + GVSGG+RKRV+  E +   
Sbjct: 143  NNVTKEEYI-----TANREFYAKIFGLTHTFDTKVGNDFISGVSGGERKRVSIAEALAAK 197

Query: 353  RKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEG 412
                  D  + GLDSST  +  + I+   +L+  T L+ + Q +   +E FD + +L  G
Sbjct: 198  GSIYCWDNATRGLDSSTALEFARAIRTMTNLLGTTALVTVYQASENIYETFDKVTVLYAG 257

Query: 413  HVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKD----------QAQYWADPSK 462
              I+ G      ++FE++G+  PPR+  A++L  ++              Q  + AD  +
Sbjct: 258  RQIFCGKTTEAKDYFENMGYLCPPRQSTAEYLTAITDPNGLHEIKPGFEYQVPHTADEFE 317

Query: 463  QYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTK-------YAVSRWEI 515
            +Y ++ S E A          Y   + T    K+     A  ++K       Y VS WE 
Sbjct: 318  KY-WLDSPEYARL--KGEIQKYKHEVNTEWTKKTYNESMAQEKSKGTRKKSYYTVSYWEQ 374

Query: 516  SKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFG 575
             + C  R  L I   +   +  TC      F+T ++F +    P+           LFF 
Sbjct: 375  IRLCTIRGFLRIYGDKSYTVINTCAAIAQAFITGSLFYQA---PSSTLGAFSRSGVLFFS 431

Query: 576  LVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVY 635
            L++    G + +S      P+  K +    Y   A +L + +   P+ +I    + +I+Y
Sbjct: 432  LLYYSLMGLANISF--EHRPILQKHKVYSLYHPSAEALASTISSFPFRMIGLTFFIIILY 489

Query: 636  YTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGF 695
            +  G   SAG FF    +L +  +    LF+M++S+   +  AN+     +L I +   +
Sbjct: 490  FLAGLHRSAGAFFTMYLLLTMCSEAITSLFQMVSSLCDTLSQANSIAGVVMLSIAMYSTY 549

Query: 696  IIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMKQSALGNNTIGY-NILHAQ--- 751
            +I    + PW+ W  ++ P+ Y   ++   EF          L  +  G+ NIL      
Sbjct: 550  MIQLPSMHPWFKWISYILPIRYAFESMLNAEFHGRHMDCGGTLVPSGPGFENILPENQVC 609

Query: 752  ----SLPSED-----------YWY-----WVSVAVLVTYAIIFNIMVTLALAYLHPLQKP 791
                S P +            Y Y     W +  ++  + I + ++  +   Y  P++  
Sbjct: 610  AFVGSRPGQSWVLGDDYLRAQYQYEYKNTWRNFGIMWCFLIGYIVLRAVFTEYKSPVKSG 669

Query: 792  RTVIP---------QDDEPEKSSSRDANYVFSTRSTKD--ESNTKGMILPFQPLTMT--- 837
               +          Q     K+   + N   +T+  K+   SN       F+ L  T   
Sbjct: 670  GDALVVKKGTKNAIQRSWSSKNDEENLNASIATQDMKEIASSNDDSTSADFEGLESTGVF 729

Query: 838  -FHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAG 896
             + NVS+ +      RK         LL +VSG   PG LTAL+G SGAGKTTL++ LA 
Sbjct: 730  IWKNVSFTIPHSSGQRK---------LLDSVSGYCVPGTLTALIGESGAGKTTLLNTLAQ 780

Query: 897  RKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEIST 956
            R  G  I GD+ + G P +  +F R +GYV+Q D+H  ++T++ESL FSA +R P+ I  
Sbjct: 781  RNVGT-ITGDMLVDGLPMDA-SFKRRTGYVQQQDLHVAELTVKESLQFSARMRRPQSIPD 838

Query: 957  DKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSII-FMDEPT 1015
             +K E+VE+++ ++E+     ALVG  G  GL+ EQRK+L+I VELV  P ++ F+DEPT
Sbjct: 839  AEKMEYVEKIISILEMQEFSEALVGEIGY-GLNVEQRKKLSIGVELVGKPDLLLFLDEPT 897

Query: 1016 SGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGV 1075
            SGLD+++A  V++ ++     G++++CTIHQPS  +FE FD LLL+ +GG+ IY G++G 
Sbjct: 898  SGLDSQSAWAVVKMLKRLALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGK 957

Query: 1076 QSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNNSDQYRGVEAS 1135
             S  +I YF+   G R   +  NPA ++LE        ++  ++ +I+  S +Y  +   
Sbjct: 958  NSSSVIKYFEK-NGARKCQQNENPAEYILEAIGAGATASVQQNWPDIWQKSHEYANINEK 1016

Query: 1136 ILEFEHPPAGSEPLKFDT---IYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISA 1192
            I +     + +   K  T    Y+ S   QF+  L + +L +WR+  Y   +M    IS 
Sbjct: 1017 INDMIKDLSSTTLHKTATRASKYATSYSYQFHHVLKRSSLTFWRNLNYIMAKMMLLMISG 1076

Query: 1193 LVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNAST--VQPIVSIERTVF-YREK 1249
            L  G  F+ +G      Q       +L+A  + I ++  +T  +Q   ++ + ++  RE 
Sbjct: 1077 LFIGFTFFHVGVNAIGLQ------NSLFACFMAIVISAPATNQIQERATVAKELYEVRES 1130

Query: 1250 AAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMIN-FERTAGKFFLYLLFMFLTFTY 1308
             + M+      +   L E+PY  + + +F + +YF +  F   +     YL +  L   Y
Sbjct: 1131 KSNMFHWSLLLITHYLNELPYHLLFSTIFFVSSYFPLGVFTEASRSSVFYLNYAILFQLY 1190

Query: 1309 FTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQWTLR 1368
            +    +M + +SP    A VI     S      G + P S +PG+W + + + P  + L+
Sbjct: 1191 YIGLALMILYMSPNLQSANVIVGFILSFLLSFCGAVQPASLMPGFWTFMWKLSPYTYFLQ 1250

Query: 1369 GVI 1371
             ++
Sbjct: 1251 NLV 1253



 Score =  153 bits (387), Expect = 3e-36
 Identities = 144/576 (25%), Positives = 252/576 (43%), Gaps = 60/576 (10%)

Query: 863  LLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKT---GGYIEGDIKISGYPKEQ--R 917
            +L NVS +   G +  ++G  GAG T+ +   AG  +   GG   G I   G P+++  +
Sbjct: 45   ILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHISYDGIPQKEMMQ 104

Query: 918  TFARISGYVEQNDIHSPQVTIEESLWFSASLRLP-KEISTDKKREFV----EQVMKLVEL 972
             +     Y  + D+H P +T++++L F+ S ++P K ++   K E++    E   K+  L
Sbjct: 105  HYKPDVIYNGEQDVHFPHLTVKQTLDFAISCKMPAKRVNNVTKEEYITANREFYAKIFGL 164

Query: 973  DSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRN 1032
                +  VG    SG+S  +RKR++IA  L A  SI   D  T GLD+  A    RA+R 
Sbjct: 165  THTFDTKVGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDSSTALEFARAIRT 224

Query: 1033 TVDT-GRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIR 1091
              +  G T + T++Q S +I+E FD + ++   GR I+ GK         DYF+ +  + 
Sbjct: 225  MTNLLGTTALVTVYQASENIYETFDKVTVLY-AGRQIFCGKTTEAK----DYFENMGYLC 279

Query: 1092 PIPRGYNPATWVLEVTTPS------------VEETIDADFAEIYNNSDQYRGVEASILEF 1139
            P PR  + A ++  +T P+            V  T D +F + + +S +Y  ++  I ++
Sbjct: 280  P-PR-QSTAEYLTAITDPNGLHEIKPGFEYQVPHTAD-EFEKYWLDSPEYARLKGEIQKY 336

Query: 1140 EHP---------------PAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMR 1184
            +H                   S+  +  + Y+ S   Q   C  +  L  +    Y  + 
Sbjct: 337  KHEVNTEWTKKTYNESMAQEKSKGTRKKSYYTVSYWEQIRLCTIRGFLRIYGDKSYTVIN 396

Query: 1185 MYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVSIE-RT 1243
                   A + G++F+   S   ST   +   G L+ S L+  +   + +    S E R 
Sbjct: 397  TCAAIAQAFITGSLFYQAPS---STLGAFSRSGVLFFSLLYYSLMGLANI----SFEHRP 449

Query: 1244 VFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKFFLYLLFMF 1303
            +  + K   +Y P A A+A  +   P+  +    F +I YF+    R+AG FF   L + 
Sbjct: 450  ILQKHKVYSLYHPSAEALASTISSFPFRMIGLTFFIIILYFLAGLHRSAGAFFTMYLLLT 509

Query: 1304 LTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPV 1363
            +     T    M   L  T   A  I+        + S ++I    +  W+ W  YI P+
Sbjct: 510  MCSEAITSLFQMVSSLCDTLSQANSIAGVVMLSIAMYSTYMIQLPSMHPWFKWISYILPI 569

Query: 1364 QWTLRGVITSQLG----DVETKII--GPGFEGTVKE 1393
            ++    ++ ++      D    ++  GPGFE  + E
Sbjct: 570  RYAFESMLNAEFHGRHMDCGGTLVPSGPGFENILPE 605


>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
            (Pleomorphic drug resistance homolog)
          Length = 1542

 Score =  458 bits (1179), Expect = e-128
 Identities = 353/1314 (26%), Positives = 610/1314 (45%), Gaps = 152/1314 (11%)

Query: 169  RPKRHSLT--ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDS-NLKKTGSITYN 225
            RP R S T  IL  + G++KPG + ++LG PG+G ++LL +++       + K   I+YN
Sbjct: 164  RPARESDTFRILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISSTTHGFQISKDSVISYN 223

Query: 226  GHEADEF--FVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENE 283
            G   +E     +    Y ++ D H   LTV +TL   AR +  Q       K + R +  
Sbjct: 224  GLTPNEIKKHYRGEVVYNAEADIHLPHLTVYQTLVTVARLKTPQNR----VKGVTREDFA 279

Query: 284  RNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRV 343
             ++                       TD  +   GL    +T VG+D++RGVSGG+RKRV
Sbjct: 280  NHV-----------------------TDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRV 316

Query: 344  TTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELF 403
            +  E+ +   K    D  + GLDS+T  + V+ +K   H+      +A+ Q + + + LF
Sbjct: 317  SIAEVWICGSKFQCWDNATRGLDSATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLF 376

Query: 404  DDLVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRK------------ 451
            + + +L EG+ IY G  ++   +F+ +G+  P R+ I DFL  ++S              
Sbjct: 377  NKVSVLYEGYQIYFGDAQHAKVYFQKMGYFCPKRQTIPDFLTSITSPAERRINKEYLDKG 436

Query: 452  --------DQAQYWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSAL 503
                    D  +YW + S++Y+ +   EI E   +       E  + H   +SK    A 
Sbjct: 437  IKVPQTPLDMVEYWHN-SEEYKQLRE-EIDETLAHQSEDDKEEIKEAHIAKQSK---RAR 491

Query: 504  ARTKYAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEA 563
              + Y VS     K    R    I     + +F+    + + F+  ++F + +   + + 
Sbjct: 492  PSSPYVVSYMMQVKYILIRNFWRIKNSASVTLFQVFGNSAMAFILGSMFYKIQKGSSADT 551

Query: 564  YGNLYVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYS 623
            +     +A+FF ++   F+   E+  +    P+  K R    Y   A +  + +  +P  
Sbjct: 552  F-YFRGAAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVISEIPPK 610

Query: 624  IIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGS 683
            I+ A+++ +I Y+ V F   AGRFF Y  I  +       LFR + S+ + +  A    S
Sbjct: 611  IVTAILFNIIFYFLVNFRRDAGRFFFYFLINVIAVFAMSHLFRCVGSLTKTLQEAMVPAS 670

Query: 684  AALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASR-----WMKQSAL 738
              LL + +  GF IP+  +  W  W ++++PL Y   ++ VNEF   R     ++ +   
Sbjct: 671  MLLLALSMYTGFAIPRTKMLGWSKWIWYINPLAYLFESLMVNEFHDRRFPCNTYIPRGGA 730

Query: 739  GNNTIGYNILHAQ--SLPSEDYWY----------------WVSVAVLVTYAIIFNIMVTL 780
             N+  G   + A   + P  DY                  W    V + Y I F  +  +
Sbjct: 731  YNDVTGTERVCASVGARPGNDYVLGDDFLKESYDYENKHKWRGFGVGMAYVIFFFFVYLI 790

Query: 781  ALAYLHPLQK-------PRTVIPQ--------------------DDEPEKSSSRDANYVF 813
               +    ++       P +V+ +                    ++  E  +S   N   
Sbjct: 791  LCEFNEGAKQKGEMLVFPHSVVKRMKKEGKIRDKTKMHTDKNDIENNSESITSNATNEKN 850

Query: 814  STRSTKDESNTKGMIL-------PFQPLTMT---FH--NVSYFVDMPQEIRKQGIPETRL 861
              + T DE+     I        P   L+ +   FH  N+ Y V +  E+R+        
Sbjct: 851  MLQDTYDENADSESITSGSRGGSPQVGLSKSEAIFHWQNLCYDVPIKTEVRR-------- 902

Query: 862  QLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGDIKISGYPKEQRTFAR 921
             +L+NV G   PG LTAL+G+SGAGKTTL+D LA R T G I GD+ ++G P++  +F+R
Sbjct: 903  -ILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERTTMGVITGDVMVNGRPRDT-SFSR 960

Query: 922  ISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVG 981
              GY +Q D+H    T+ ESL FSA LR P  +S ++K E+VE V+K++E+++  +A+VG
Sbjct: 961  SIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNEYVEAVIKILEMETYADAVVG 1020

Query: 982  MPGSSGLSTEQRKRLTIAVELVANPSI-IFMDEPTSGLDARAAAIVMRAVRNTVDTGRTV 1040
            +PG  GL+ EQRKRLTI VEL A P + +F+DEPTSGLD++ A    + ++   + G+ +
Sbjct: 1021 VPGE-GLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWATCQLMKKLANHGQAI 1079

Query: 1041 VCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPA 1100
            +CTIHQPS  + + FD LL +++GG+ +Y G LG   + MI YF+   G    P   NPA
Sbjct: 1080 LCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLGKGCKTMIKYFED-HGAHKCPPDANPA 1138

Query: 1101 TWVLEVTTPSVEETIDADFAEIYNNSDQYRGVEASILEFEHPPAGSE---PLKFDTIYSQ 1157
             W+LEV   +     + D+ E++ NS+Q++ V+  + + E   +  E       +  ++ 
Sbjct: 1139 EWMLEVVGAAPGSHANQDYHEVWRNSEQFKQVKQELEQMEKELSQKELDNDEDANKEFAT 1198

Query: 1158 SLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMG 1217
            SL  QF     +    YWR+P Y   +   T  + L  G  F+       +   L  +  
Sbjct: 1199 SLWYQFQLVCVRLFQQYWRTPDYLWSKYILTIFNQLFIGFTFF------KADHTLQGLQN 1252

Query: 1218 ALYASCLFIGVNNASTVQ--PIVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQ 1274
             + +  ++  + N    Q  P    +R ++  RE+ +  +S  A+ +AQ ++E+P+  V 
Sbjct: 1253 QMLSIFMYTVIFNPLLQQYLPTFVQQRDLYEARERPSRTFSWKAFILAQIVVEVPWNIVA 1312

Query: 1275 AMVFGLITYFMINFERTAGKFF-------LYLLFMFLTFTYFTFYGMMAVGLSPTQHLAA 1327
              +   I Y+ + F   A +         L+ LF    + Y    G+  +  +     AA
Sbjct: 1313 GTLAYCIYYYSVGFYANASQAHQLHERGALFWLFSIAFYVYVGSLGLFVISFNEVAETAA 1372

Query: 1328 VISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDVETK 1381
             I S  +++     G +     +P +WI+ Y + P+ + +  ++++ + +V+ +
Sbjct: 1373 HIGSLMFTMALSFCGVMATPDAMPRFWIFMYRVSPLTYLIDALLSTGVANVDIR 1426


>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
          Length = 1529

 Score =  453 bits (1165), Expect = e-126
 Identities = 350/1338 (26%), Positives = 608/1338 (45%), Gaps = 140/1338 (10%)

Query: 131  FSNLSVSADVQIGSRALPTLINYTRDALETICTNLGIYRPKRHSLT--ILDNVSGVIKPG 188
            + NLS S D    S  +     +     + +   L + +P +   T  IL  + G + PG
Sbjct: 141  WKNLSASGD----SADVSYQSTFANIVPKLLTKGLRLLKPSKEEDTFQILKPMDGCLNPG 196

Query: 189  RMTLLLGAPGAGKSSLLLALAGKLDS-NLKKTGSITYNGHEADEF--FVKRTCAYISQTD 245
             + ++LG PG+G ++LL +++       + K   ++YNG  + +     +    Y +++D
Sbjct: 197  ELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSSDIRKHYRGEVVYNAESD 256

Query: 246  NHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFMKASSVGGKK 305
             H   LTV +TL   AR +  Q                        +D    A+ V    
Sbjct: 257  IHLPHLTVYQTLFTVARMKTPQNRIKG-------------------VDREAYANHV---- 293

Query: 306  HSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPRKTLFMDEISTGL 365
                T+  +   GL    +T VG+D++RGVSGG+RKRV+  E+ +   +    D  + GL
Sbjct: 294  ----TEVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGL 349

Query: 366  DSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIYEGPRENVLE 425
            DS+T  + ++ +K    +      +A+ Q + + ++LFD + +L +G+ +Y GP ++  +
Sbjct: 350  DSATALEFIRALKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAKK 409

Query: 426  FFESIGFKLPPRKGIADFLQEVSSR--------------------KDQAQYWADPSKQYQ 465
            +F+ +G+  PPR+  ADFL  ++S                     KD A+YW   S+ Y+
Sbjct: 410  YFQDMGYYCPPRQTTADFLTSITSPTERIISKEFIEKGTRVPQTPKDMAEYWLQ-SESYK 468

Query: 466  FVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEISKACFAREAL 525
             +     +   +N+     +     H     +  PS+     Y V+     K    R   
Sbjct: 469  NLIKDIDSTLEKNTDEARNIIRDAHHAKQAKRAPPSS----PYVVNYGMQVKYLLIRNFW 524

Query: 526  LISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMFNGFS 585
             + +   + +++    + + F+  ++F +  M   D +      +A+FF ++   F+   
Sbjct: 525  RMKQSASVTLWQVIGNSVMAFILGSMFYKV-MKKNDTSTFYFRGAAMFFAILFNAFSCLL 583

Query: 586  ELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAG 645
            E+  +    P+  K R    Y   A +  + +  +P  +I AV + +I Y+ V F  + G
Sbjct: 584  EIFSLYETRPITEKHRTYSLYHPSADAFASVLSEMPPKLITAVCFNIIFYFLVDFRRNGG 643

Query: 646  RFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPW 705
             FF Y  I  +       LFR + S+ + +  A    S  LL I +  GF IPK  I  W
Sbjct: 644  VFFFYFLINVIATFTLSHLFRCVGSLTKTLQEAMVPASMLLLAISMYTGFAIPKTKILGW 703

Query: 706  WIWGYWLSPLTYGQRAITVNEFTASRWMKQSALGNNTIGYNILHAQSLPS---------- 755
             IW ++++PL Y   ++ +NEF   R+     +       NI   Q + S          
Sbjct: 704  SIWIWYINPLAYLFESLMINEFHDRRFPCAQYIPAGPAYQNITGTQRVCSAVGAYPGNDY 763

Query: 756  --------EDYWY-----WVSVAVLVTYAIIFNIMVTLALAYLHPL-QKPRTVI------ 795
                    E Y Y     W    + + Y + F  +  +   Y     QK   V+      
Sbjct: 764  VLGDDFLKESYDYEHKHKWRGFGIGMAYVVFFFFVYLILCEYNEGAKQKGEMVVFLRSKI 823

Query: 796  --------------PQDDEPEKSSSRDA----NYVFSTRSTKDESNTKGMILPFQPLTMT 837
                          P D E    SS D+      +    S   +S++    L        
Sbjct: 824  KQLKKEGKLQEKHRPGDIENNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGLSKSEAI 883

Query: 838  FHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGR 897
            FH      D+P       I   + ++L+NV G   PG LTAL+G+SGAGKTTL+D LA R
Sbjct: 884  FHWRDLCYDVP-------IKGGQRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAER 936

Query: 898  KTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTD 957
             T G I G+I + G  +++ +F R  GY +Q D+H    T+ ESL FSA LR P  +S +
Sbjct: 937  VTMGVITGNIFVDGRLRDE-SFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIE 995

Query: 958  KKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSI-IFMDEPTS 1016
            +K  +VE+V+K++E+    +A+VG+ G  GL+ EQRKRLTI VEL A P + +F+DEPTS
Sbjct: 996  EKNRYVEEVIKILEMQQYSDAVVGVAGE-GLNVEQRKRLTIGVELAARPKLLVFLDEPTS 1054

Query: 1017 GLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQ 1076
            GLD++ A    + +R     G+ ++CTIHQPS  + + FD LL +++GG+ +Y G LG  
Sbjct: 1055 GLDSQTAWDTCQLMRKLATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEG 1114

Query: 1077 SQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNNSDQYRGVEASI 1136
             + MIDYF+  +G    P   NPA W+LEV   +       D+ E++ NSD+Y+ V+  +
Sbjct: 1115 CKTMIDYFES-KGAHKCPPDANPAEWMLEVVGAAPGSHATQDYNEVWRNSDEYKAVQEEL 1173

Query: 1137 --LEFEHPPAGSEPLKFD-TIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISAL 1193
              +E   P    EP   +   ++ SL  QF     +    YWRSP Y   +   T  + +
Sbjct: 1174 DWMEKNLPGRSKEPTAEEHKPFAASLYYQFKMVTIRLFQQYWRSPDYLWSKFILTIFNQV 1233

Query: 1194 VFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVS-IERTVFY--REKA 1250
              G  F+       + + L  +   + +  ++  + N    Q + S +++   Y  RE+ 
Sbjct: 1234 FIGFTFF------KADRSLQGLQNQMLSIFMYTVIFNPILQQYLPSFVQQRDLYEARERP 1287

Query: 1251 AGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAG-------KFFLYLLFMF 1303
            +  +S +A+ ++Q ++EIP+  +   +   I Y+ + F   A        +  L+ LF  
Sbjct: 1288 SRTFSWLAFFLSQIIVEIPWNILAGTIAYCIYYYAVGFYANASAAGQLHERGALFWLFSI 1347

Query: 1304 LTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPV 1363
              + Y    G++ +  +     AA + +  +++     G +     +P +WI+ Y + P+
Sbjct: 1348 AFYVYIGSMGLLMISFNEVAETAAHMGTLLFTMALSFCGVMATPKVMPRFWIFMYRVSPL 1407

Query: 1364 QWTLRGVITSQLGDVETK 1381
             + +  ++   + +V+ K
Sbjct: 1408 TYMIDALLALGVANVDVK 1425


>SNQ2_YEAST (P32568) SNQ2 protein
          Length = 1501

 Score =  440 bits (1132), Expect = e-122
 Identities = 343/1289 (26%), Positives = 590/1289 (45%), Gaps = 142/1289 (11%)

Query: 161  ICTNLGIYR---PKRHSLT--ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSN 215
            +C  L I++    KRH     I+ NV+ + + G M L+LG PGAG SS L   AG++D  
Sbjct: 154  LCLPLTIFKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQF 213

Query: 216  LKK-TGSITYNGHEADEFF--VKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAA 272
                +G + Y+G   +E     K    Y  + D H   LTV++TLDFA  C+        
Sbjct: 214  AGGVSGEVAYDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACK-------- 265

Query: 273  YTKDIGRLENERNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDML 332
                           P+  ++   K   +  ++     D    + GL     T VG+D +
Sbjct: 266  --------------TPALRVNNVSKKEYIASRR-----DLYATIFGLRHTYNTKVGNDFV 306

Query: 333  RGVSGGQRKRVTTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMAL 392
            RGVSGG+RKRV+  E +         D  + GLD+ST  +  K I+   +L+ +T  + +
Sbjct: 307  RGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIRIMTNLLKSTAFVTI 366

Query: 393  LQPAPETFELFDDLVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSR-- 450
             Q +   +E FD + +L  G  IY G       +F  +G+  PPR+  A+FL  ++    
Sbjct: 367  YQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKMGYLCPPRQATAEFLTALTDPNG 426

Query: 451  --------KDQAQYWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHP----YDKSKC 498
                    +++    A+  + Y ++ S E A+  ++    +Y E + T      YD+S  
Sbjct: 427  FHLIKPGYENKVPRTAEEFETY-WLNSPEFAQMKKD--IAAYKEKVNTEKTKEVYDESMA 483

Query: 499  HPSALARTK---YAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRT 555
               +    K   Y VS WE  K C  R    I   +   +   C      F+T ++F  T
Sbjct: 484  QEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYTVINVCSAIIQSFITGSLFYNT 543

Query: 556  RMHPTDEAYGNLYVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTN 615
               P+  +        L+F L++    G + +S      P+  K +    Y   A ++ +
Sbjct: 544  ---PSSTSGAFSRGGVLYFALLYYSLMGLANISF--EHRPILQKHKGYSLYHPSAEAIGS 598

Query: 616  WVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDM 675
             +   P+ +I    + +I+++  G   +AG FF     L +  +   GLF M++S+   +
Sbjct: 599  TLASFPFRMIGLTCFFIILFFLSGLHRTAGSFFTIYLFLTMCSEAINGLFEMVSSVCDTL 658

Query: 676  VLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMKQ 735
              AN+     ++ I +   ++I    + PW+ W  ++ P+ Y   ++   EF        
Sbjct: 659  SQANSISGILMMSISMYSTYMIQLPSMHPWFKWISYVLPIRYAFESMLNAEFHGRHMDCA 718

Query: 736  SALGNNTIGYNILHAQ--------SLPSEDYWY----------------WVSVAVLVTYA 771
            + L  +   Y+ L           S P + Y                  W +  +L  + 
Sbjct: 719  NTLVPSGGDYDNLSDDYKVCAFVGSKPGQSYVLGDDYLKNQFQYVYKHTWRNFGILWCFL 778

Query: 772  IIFNIMVTLALAYLHPLQ-----------KPRTVIPQDDE-PEKSSSRDANYVFSTRSTK 819
            + + ++  +   Y  P++             R +   D+E P+  +  DA   FS+ S+ 
Sbjct: 779  LGYVVLKVIFTEYKRPVKGGGDALIFKKGSKRFIAHADEESPDNVNDIDAKEQFSSESSG 838

Query: 820  ------DESNTKGMILPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSP 873
                  D+   KG+ +        + +V + +  P E  K+        LL NVSG   P
Sbjct: 839  ANDEVFDDLEAKGVFI--------WKDVCFTI--PYEGGKR-------MLLDNVSGYCIP 881

Query: 874  GVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHS 933
            G +TAL+G SGAGKTTL++ LA R  G  I GD+ ++G P +  +F R +GYV+Q DIH 
Sbjct: 882  GTMTALMGESGAGKTTLLNTLAQRNVG-IITGDMLVNGRPIDA-SFERRTGYVQQQDIHI 939

Query: 934  PQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQR 993
             ++T+ ESL FSA +R P+ +   +K ++VE++++++ ++    ALVG  G  GL+ EQR
Sbjct: 940  AELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGC-GLNVEQR 998

Query: 994  KRLTIAVELVANPSII-FMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIF 1052
            K+L+I VELVA P ++ F+DEPTSGLD++++  +++ +R     G++++CTIHQPS  +F
Sbjct: 999  KKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILCTIHQPSATLF 1058

Query: 1053 EAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVE 1112
            E FD LLL+++GG+ +Y G +G  S  +++YF+   G R      NPA ++LE       
Sbjct: 1059 EEFDRLLLLRKGGQTVYFGDIGKNSATILNYFER-NGARKCDSSENPAEYILEAIGAGAT 1117

Query: 1113 ETIDADFAEIYNNSDQYRGVEASILEF--------EHPPAGSEPLKFDTIYSQSLLSQFY 1164
             ++  D+ E + NS ++   +  + +              G +P K+ T Y+     QF 
Sbjct: 1118 ASVKEDWHEKWLNSVEFEQTKEKVQDLINDLSKQETKSEVGDKPSKYATSYAY----QFR 1173

Query: 1165 RCLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCL 1224
              L + +  +WRS  Y   +M    +  L  G  F+++G      Q     M A + S +
Sbjct: 1174 YVLIRTSTSFWRSLNYIMSKMMLMLVGGLYIGFTFFNVGKSYVGLQN---AMFAAFIS-I 1229

Query: 1225 FIGVNNASTVQPIVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITY 1283
             +     + +Q      R +F  RE  + M+      + Q L E+PY    + +F + +Y
Sbjct: 1230 ILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHLFFSTIFFVSSY 1289

Query: 1284 FMINFERTAGKFFLYLLFMFLTF-TYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSG 1342
            F +     A +  +Y L   + F  Y+   G+M + +SP    A VI     S      G
Sbjct: 1290 FPLRIFFEASRSAVYFLNYCIMFQLYYVGLGLMILYMSPNLPSANVILGLCLSFMLSFCG 1349

Query: 1343 FLIPESHIPGWWIWFYYICPVQWTLRGVI 1371
               P S +PG+W + +   P  + ++ ++
Sbjct: 1350 VTQPVSLMPGFWTFMWKASPYTYFVQNLV 1378



 Score =  136 bits (343), Expect = 4e-31
 Identities = 127/556 (22%), Positives = 242/556 (42%), Gaps = 63/556 (11%)

Query: 862  QLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGR--KTGGYIEGDIKISGYPKEQ--R 917
            Q++SNV+ +   G +  ++G  GAG ++ + V AG   +  G + G++   G P+E+  +
Sbjct: 174  QIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVAYDGIPQEEMMK 233

Query: 918  TFARISGYVEQNDIHSPQVTIEESLWFSASLRLPK-EISTDKKREFVEQVMKLVE----L 972
             +     Y  + D+H P +T++++L F+ + + P   ++   K+E++     L      L
Sbjct: 234  RYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYIASRRDLYATIFGL 293

Query: 973  DSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRN 1032
                N  VG     G+S  +RKR++IA  L A  SI   D  T GLDA  A    +A+R 
Sbjct: 294  RHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIRI 353

Query: 1033 TVDTGR-TVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYG------------GKLGVQSQI 1079
              +  + T   TI+Q S +I+E FD + ++  G ++ +G            G L    Q 
Sbjct: 354  MTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKMGYLCPPRQA 413

Query: 1080 MIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNNSDQYRGVEASILEF 1139
              ++   +      P G++      E   P   E    +F   + NS ++  ++  I  +
Sbjct: 414  TAEFLTALTD----PNGFHLIKPGYENKVPRTAE----EFETYWLNSPEFAQMKKDIAAY 465

Query: 1140 EHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQN---LVYWR---------------SPPYN 1181
            +     +E  K   +Y +S+  +  +   K++   + YW                +  Y 
Sbjct: 466  KEK-VNTEKTK--EVYDESMAQEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYT 522

Query: 1182 AMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVSIE 1241
             + +    I + + G++F++  S   ST   +   G LY + L+  +   + +    S E
Sbjct: 523  VINVCSAIIQSFITGSLFYNTPS---STSGAFSRGGVLYFALLYYSLMGLANI----SFE 575

Query: 1242 -RTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKFFLYLL 1300
             R +  + K   +Y P A A+   L   P+  +    F +I +F+    RTAG FF   +
Sbjct: 576  HRPILQKHKGYSLYHPSAEAIGSTLASFPFRMIGLTCFFIILFFLSGLHRTAGSFFT--I 633

Query: 1301 FMFLTFTYFTFYGM--MAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFY 1358
            ++FLT       G+  M   +  T   A  IS       ++ S ++I    +  W+ W  
Sbjct: 634  YLFLTMCSEAINGLFEMVSSVCDTLSQANSISGILMMSISMYSTYMIQLPSMHPWFKWIS 693

Query: 1359 YICPVQWTLRGVITSQ 1374
            Y+ P+++    ++ ++
Sbjct: 694  YVLPIRYAFESMLNAE 709


>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
          Length = 1501

 Score =  439 bits (1129), Expect = e-122
 Identities = 347/1281 (27%), Positives = 582/1281 (45%), Gaps = 135/1281 (10%)

Query: 173  HSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGS-ITYNGHEADE 231
            +S  IL  + G+IKPG +T++LG PGAG S+ L  +A + +      GS I+Y+G   DE
Sbjct: 156  YSFDILKPMEGLIKPGEVTVVLGRPGAGCSTFLKTIACRTEGFHVADGSVISYDGITQDE 215

Query: 232  F--FVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPS 289
                ++    Y ++T+ H   LTV ETL+FAA  +  Q                   RP 
Sbjct: 216  IRNHLRGEVVYCAETETHFPNLTVGETLEFAALMKTPQN------------------RP- 256

Query: 290  PEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMI 349
                  M  S     KH V  D ++   GL     T VG+D +RG+SGG+RKR++  E+ 
Sbjct: 257  ------MGVSREEYAKHVV--DVVMATYGLSHTKNTKVGNDFIRGISGGERKRLSIAEVT 308

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
            +        D  + GLD++T  + +  +K    +++ T L+A+ Q +   ++LFD ++++
Sbjct: 309  LVQASIQCWDNSTRGLDAATALEFISSLKTSASILNDTPLIAIYQCSQNAYDLFDKVIVM 368

Query: 410  SEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSR-----------------KD 452
             EG+ I+ G  +    +F+ +GF    R+   DFL  ++S                  K+
Sbjct: 369  YEGYQIFFGSSQRAAAYFKKMGFVCQDRQTTPDFLTSITSPAERIIKPGYERLVPRTPKE 428

Query: 453  QAQYWA-DPSKQYQFVPSGEIAEAFRN-----SRFGSYVESLQTHPYDKSKCHPSALART 506
              +YW   P +Q       E  +   N       F +       H Y+KS    S   + 
Sbjct: 429  FYRYWRRSPERQALLEEIDEYLDNCENYDQKQKIFEANNAKKAKHTYNKSSYTVSLPMQV 488

Query: 507  KYAVSR-WEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYG 565
            +Y + R W+              R R   I     VA  G +   + L +  +       
Sbjct: 489  RYIMKRYWD--------------RMRGDIIVPLSTVA--GNIAMALILSSVFYNLQPNSS 532

Query: 566  NLY--VSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYS 623
            + Y   S +++ L+   ++   E+  M     +  K R+   YP  A ++ + +   P  
Sbjct: 533  SFYYRTSVMYYALLFNAYSSVLEIYNMYEGRAIVQKHREYALYPPMADAIGSIISDFPLK 592

Query: 624  IIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGS 683
            ++ +V++ +I+Y+ V F    G FF Y+ I F        LFR + +    +  A T  S
Sbjct: 593  VVCSVLFNLILYFMVNFKREPGAFFFYLLISFCSTLFMSHLFRTIGAFTNSLAEAMTPSS 652

Query: 684  AALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRW----MKQSALG 739
              L  +    GF IP   +  W  W  W++PL Y   A+  NEF    +    +  S  G
Sbjct: 653  LLLFALSTFSGFAIPVTYMLGWCKWIRWVNPLAYAYEALISNEFHGRVFDCSNIVPSGFG 712

Query: 740  NNTIGYNILHAQ--SLPSE-------------DYWY---WVSVAVLVTYAI-IFNIMVTL 780
                G +++ A   +LP E             DY Y   W +  VL+ + I +F   +  
Sbjct: 713  YPKTGNSVVCASIGALPGEFKVDGDLYLKLAFDYSYSNVWRNFGVLMAFIIFLFGTTIFF 772

Query: 781  ALAYLHPLQKPRTVI----------PQDDEPEKSSSRDANYVFSTRSTKDESNTKGMILP 830
                   + K  T++            +++ E      A   FS  +   + +   M   
Sbjct: 773  VQTNKSSISKGETLVFRRKNIRKMRKMEEDEEAYMDGMAPLDFSGSTEISDYSYDYMDRK 832

Query: 831  FQPLTMTFH--NVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKT 888
                +  FH  N++Y V +  E R          +L+N+ G   PG +TAL+G+SGAGKT
Sbjct: 833  LLDTSNIFHWRNLTYTVKIKSEERV---------ILNNIDGWVKPGEVTALMGASGAGKT 883

Query: 889  TLMDVLAGRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASL 948
            TL++ L+ R T G I    ++    +   +F R  GYV+Q D+H    T+ E+L FSA L
Sbjct: 884  TLLNALSERLTTGVITSGTRMVNGGELDSSFQRSIGYVQQQDLHLETSTVREALKFSARL 943

Query: 949  RLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPS- 1007
            R P  +S  +K  +VE+++ L+E+ +  +A+VG+PG  GL+ EQRKRLTIAVELVA P  
Sbjct: 944  RQPNSVSIAEKDSYVEKIIDLLEMRTYVDAIVGVPG-EGLNVEQRKRLTIAVELVARPKL 1002

Query: 1008 IIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRV 1067
            ++F+DEPTSGLD++ A  + + +R   + G+ ++CTIHQPS  + E FD LLL+++ G  
Sbjct: 1003 LVFLDEPTSGLDSQTAWSICKLIRKLANHGQAILCTIHQPSAILLEEFDRLLLLQK-GET 1061

Query: 1068 IYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNNSD 1127
            +Y G+ G     +I+YF+   G    P+  NPA W+L V   +     + D+ E + NS 
Sbjct: 1062 VYFGEFGANCHTLIEYFER-NGASKCPQHANPAEWMLGVIGAAPGTQANQDYFETWRNSP 1120

Query: 1128 QYRGVEASILEFEHPP---AGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMR 1184
            +YR V+  +   E  P   +G +    +  Y+ S   Q+   + +    YWR+P Y   +
Sbjct: 1121 EYRAVQNELHRLEEMPGLASGEKEPDTNQAYAASFWKQYIFVVHRLFQQYWRTPSYIYSK 1180

Query: 1185 MYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVSIERTV 1244
                 + +L  G  ++     ++S Q L   M +++ S   +    A    P+   +R +
Sbjct: 1181 FAMAVLCSLFNGFTYY---KSQNSMQGLKNQMLSIF-SMFVVLTTLAQQYVPLFVTQRDL 1236

Query: 1245 F-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTA-------GKFF 1296
            +  RE+ +  +S +A+  AQ   EIPY  + A +     Y+ +   R A        +  
Sbjct: 1237 YEARERPSKTFSWLAFIAAQITAEIPYQVLAATISFFSWYYPVGLYRNAVYSGAVTHRGV 1296

Query: 1297 LYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIW 1356
            L  L M L F Y +      +  +     AA   S   ++  +  G +  +  +P +W++
Sbjct: 1297 LMWLIMTLMFIYSSTLAQFCISWNQLADYAANWISLLLTISMIFCGVIATKDSMPKFWVF 1356

Query: 1357 FYYICPVQWTLRGVITSQLGD 1377
             Y   P+ +    +++  LGD
Sbjct: 1357 LYRCTPLTYLTSAMMSIGLGD 1377



 Score =  125 bits (314), Expect = 8e-28
 Identities = 145/576 (25%), Positives = 245/576 (42%), Gaps = 91/576 (15%)

Query: 171  KRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEAD 230
            K     IL+N+ G +KPG +T L+GA GAGK++LL AL+ +L + +  +G+   NG E D
Sbjct: 852  KSEERVILNNIDGWVKPGEVTALMGASGAGKTTLLNALSERLTTGVITSGTRMVNGGELD 911

Query: 231  EFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSP 290
              F +R+  Y+ Q D H    TVRE L F+AR +                          
Sbjct: 912  SSF-QRSIGYVQQQDLHLETSTVREALKFSARLR-------------------------- 944

Query: 291  EIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMI 349
                  + +SV   +     + I+ +L +    + IVG     G++  QRKR+T   E++
Sbjct: 945  ------QPNSVSIAEKDSYVEKIIDLLEMRTYVDAIVGVPG-EGLNVEQRKRLTIAVELV 997

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
              P+  +F+DE ++GLDS T + I K I+   +   A +L  + QP+    E FD L+LL
Sbjct: 998  ARPKLLVFLDEPTSGLDSQTAWSICKLIRKLANHGQA-ILCTIHQPSAILLEEFDRLLLL 1056

Query: 410  SEGHVIYEGP----RENVLEFFESIG-FKLPPRKGIADFLQEVSSRKDQAQYWADPSKQY 464
             +G  +Y G        ++E+FE  G  K P     A+++  V          A P  Q 
Sbjct: 1057 QKGETVYFGEFGANCHTLIEYFERNGASKCPQHANPAEWMLGVIG--------AAPGTQ- 1107

Query: 465  QFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEISKACFAREA 524
                + +  E +RNS     V++ + H  ++       LA  +      +   A F ++ 
Sbjct: 1108 ---ANQDYFETWRNSPEYRAVQN-ELHRLEEM----PGLASGEKEPDTNQAYAASFWKQY 1159

Query: 525  LLISRQRFLYIFKTCQVAFVGF---VTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMF 581
            + +  + F   ++T    +  F   V C++F     + +  +   L    L       +F
Sbjct: 1160 IFVVHRLFQQYWRTPSYIYSKFAMAVLCSLFNGFTYYKSQNSMQGLKNQML------SIF 1213

Query: 582  NGFSELSLMIAR-LPVFYKQRDNLFYPA---------W-AWSLTNWVLRVPYSIIEAVIW 630
            + F  L+ +  + +P+F  QRD   Y A         W A+        +PY ++ A I 
Sbjct: 1214 SMFVVLTTLAQQYVPLFVTQRD--LYEARERPSKTFSWLAFIAAQITAEIPYQVLAATIS 1271

Query: 631  TVIVYYTVGFAPSA---------GRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTF 681
                YY VG   +A         G     +  L  ++   +  F +  +   D   A  +
Sbjct: 1272 FFSWYYPVGLYRNAVYSGAVTHRGVLMWLIMTLMFIYSSTLAQFCISWNQLAD--YAANW 1329

Query: 682  GSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTY 717
             S  L +  +  G I  K  +  +W++ Y  +PLTY
Sbjct: 1330 ISLLLTISMIFCGVIATKDSMPKFWVFLYRCTPLTY 1365


>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
          Length = 1499

 Score =  435 bits (1119), Expect = e-121
 Identities = 349/1291 (27%), Positives = 596/1291 (46%), Gaps = 148/1291 (11%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALA-GKLDSNLKKTGSITYNG---HEADEF 232
            IL ++  +++PG +T++LG PGAG S+LL  +A      ++ K   ITY+G   H+ +  
Sbjct: 167  ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 226

Query: 233  FVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEI 292
            + +    Y ++TD H   L+V +TL+FAAR +  Q       ++                
Sbjct: 227  Y-RGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYA------------- 272

Query: 293  DAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGP 352
                        KH  +    +   GL     T VG+D +RGVSGG+RKRV+  E  +  
Sbjct: 273  ------------KHMASV--YMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSG 318

Query: 353  RKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEG 412
                  D  + GLDS+T  + ++ +K    ++D T L+A+ Q + + +ELFD++V+L EG
Sbjct: 319  ANIQCWDNATRGLDSATALEFIRALKTSATILDTTPLIAIYQCSQDAYELFDNVVVLYEG 378

Query: 413  HVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQ----------------- 455
            + I+ G      E+FE++G+K P R+  ADFL  +++  ++                   
Sbjct: 379  YQIFFGKASKAKEYFENMGWKCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFET 438

Query: 456  YWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDK--SKCHPSALARTKYAVSRW 513
            +W +  +  +     EI E F      +  E+ +     K  +   PS+     Y VS +
Sbjct: 439  FWKNSPEYAELTK--EIDEYFVECERSNTGETYRESHVGKQSNNTRPSS----PYTVSFF 492

Query: 514  EISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALF 573
               +   AR  L +     + +        +G +  ++F   R   TD  Y      ALF
Sbjct: 493  MQVRYVIARNFLRMKGDPSIPLISILSQLVMGLILASVFFNLRKS-TDTFY--FRGGALF 549

Query: 574  FGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVI 633
            F ++   F+   E+  +    P+  K R    Y   A +L + +  +P  ++  + + ++
Sbjct: 550  FSVLFNAFSSLLEILSLYEARPIVEKHRKYALYRPSADALASIISELPVKLLMTMSFNIV 609

Query: 634  VYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLG 693
             Y+ V    +AG FF Y  +      +   +FR + ++   +  A +  +  LL + +  
Sbjct: 610  YYFMVNLRRTAGNFFFYWLMCASCTLVMSHMFRSIGAVTTTIATAMSLSTVFLLAMIIYA 669

Query: 694  GFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWM------------------KQ 735
            GF++P   I  W  W  +++P+TY   ++ VNEF    +                   K 
Sbjct: 670  GFVLPIPYILGWSRWIRYINPVTYIFESLMVNEFHGREFECGQYIPSGPGFENLPVENKV 729

Query: 736  SALGNNTIGYNILHAQSLPSEDYWY-----WVSVAVLVTYAIIFNIMVTLALAYLHP--- 787
                 +T G  ++         Y +     W +  + V +A+ F + V +AL   +    
Sbjct: 730  CTTVGSTPGSTVVQGTEYIKLAYQFYSSHKWRNFGITVAFAVFF-LGVYVALTEFNKGAS 788

Query: 788  --------------LQKPRTVIPQDDEPE------KSSSRDANYVFSTRSTKDESNTKGM 827
                            K +T      + E      K   +D     +     ++ +T  +
Sbjct: 789  QKGEIVLFLKGSLKKHKRKTAASNKGDIEAGPVAGKLDYQDEAEAVNNEKFTEKGSTGSV 848

Query: 828  ILPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGK 887
              P       + +++Y V + +E R          +L +V G   PG +TAL+G+SGAGK
Sbjct: 849  DFPENREIFFWRDLTYQVKIKKEDRV---------ILDHVDGWVKPGQITALMGASGAGK 899

Query: 888  TTLMDVLAGRKTGGYI-EGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSA 946
            TTL++ L+ R T G I +G+  ++G+  +  +F R  GYV+Q D+H    T+ E+L FSA
Sbjct: 900  TTLLNCLSERVTTGIITDGERLVNGHALDS-SFQRSIGYVQQQDVHLETTTVREALQFSA 958

Query: 947  SLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANP 1006
             LR   +IS  +K ++V+ V+ L+E+    +ALVG+ G  GL+ EQRKRLTI VELVA P
Sbjct: 959  YLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVELVAKP 1017

Query: 1007 S-IIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGG 1065
              ++F+DEPTSGLD++ A  + + +R   D G+ ++CTIHQPS  I   FD LL +++GG
Sbjct: 1018 KLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCTIHQPSALIMAEFDKLLFLQKGG 1077

Query: 1066 RVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNN 1125
            R  Y G+LG   Q MI+YF+   G  P P+  NPA W+L+V   +       D+ E++ N
Sbjct: 1078 RTAYFGELGENCQTMINYFEKY-GADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRN 1136

Query: 1126 SDQYRGVEASI----LEFEHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYN 1181
            S +Y+ V   I     E    P  ++P      Y+  L  Q+    W+  +  WRSP Y 
Sbjct: 1137 SSEYQAVREEINRMEAELSKLPRDNDPEAL-LKYAAPLWKQYLLVSWRTIVQDWRSPGYI 1195

Query: 1182 AMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNN-ASTVQPIVSI 1240
              ++     S+L  G  F+     +++ Q L   M A++    F+        + P    
Sbjct: 1196 YSKLILVISSSLFIGFSFF---KSKNNLQGLQSQMLAVF--MFFVPFTTFIDQMLPYFVK 1250

Query: 1241 ERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYF--------MINFERT 1291
             R V+  RE  +  +S  A+   Q   EIP+     +V G I+YF          N E T
Sbjct: 1251 HRAVYEVREAPSRTFSWFAFIAGQITSEIPF----QIVVGTISYFCWYYPVGLYANAEPT 1306

Query: 1292 -AGKFFLYLLFMFLT--FTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPES 1348
             +      L++M LT  + Y +  G +A+ L+     AA +++  ++L  +  G L   +
Sbjct: 1307 DSVNSRGVLMWMLLTAFYVYTSTMGQLAISLNELIDNAANLATTLFTLCLMFCGVLAGPN 1366

Query: 1349 HIPGWWIWFYYICPVQWTLRGVITSQLGDVE 1379
             IPG+WI+ Y   P  + ++ ++++ L + +
Sbjct: 1367 VIPGFWIFMYRCNPFTYLIQAILSTGLANAK 1397



 Score =  164 bits (415), Expect = 2e-39
 Identities = 148/571 (25%), Positives = 258/571 (44%), Gaps = 61/571 (10%)

Query: 863  LLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYI--EGDIKISGYPKE--QRT 918
            +L ++  +  PG LT ++G  GAG +TL+  +A    G +I  E  I   G      +R 
Sbjct: 167  ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 226

Query: 919  FARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVE-----LD 973
            +     Y  + D+H P +++ ++L F+A LR P+       RE   + M  V      L 
Sbjct: 227  YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATYGLS 286

Query: 974  SLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRNT 1033
              RN  VG     G+S  +RKR++IA   ++  +I   D  T GLD+  A   +RA++ +
Sbjct: 287  HTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKTS 346

Query: 1034 ---VDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGI 1090
               +DT  T +  I+Q S D +E FD+++++  G ++ +G     ++    +YF+ +   
Sbjct: 347  ATILDT--TPLIAIYQCSQDAYELFDNVVVLYEGYQIFFG-----KASKAKEYFENMGW- 398

Query: 1091 RPIPRGYNPATWVLEVTTPSVEETIDA----------DFAEIYNNSDQYRGVEASILEF- 1139
               P+    A ++  +T P+  E +            +F   + NS +Y  +   I E+ 
Sbjct: 399  -KCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETFWKNSPEYAELTKEIDEYF 457

Query: 1140 --------------EHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRM 1185
                           H    S   +  + Y+ S   Q    + +  L     P    + +
Sbjct: 458  VECERSNTGETYRESHVGKQSNNTRPSSPYTVSFFMQVRYVIARNFLRMKGDPSIPLISI 517

Query: 1186 YFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVSI--ERT 1243
                +  L+  +VF+++   R ST   Y   GAL+ S LF   N  S++  I+S+   R 
Sbjct: 518  LSQLVMGLILASVFFNL---RKSTDTFYFRGGALFFSVLF---NAFSSLLEILSLYEARP 571

Query: 1244 VFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKFFLYLLFMF 1303
            +  + +   +Y P A A+A  + E+P   +  M F ++ YFM+N  RTAG FF Y L M 
Sbjct: 572  IVEKHRKYALYRPSADALASIISELPVKLLMTMSFNIVYYFMVNLRRTAGNFFFYWL-MC 630

Query: 1304 LTFTYFTFYGMMAVG-LSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICP 1362
             + T    +   ++G ++ T   A  +S+ F     + +GF++P  +I GW  W  YI P
Sbjct: 631  ASCTLVMSHMFRSIGAVTTTIATAMSLSTVFLLAMIIYAGFVLPIPYILGWSRWIRYINP 690

Query: 1363 VQWTLRGVITSQLGDVETKI-----IGPGFE 1388
            V +    ++ ++    E +       GPGFE
Sbjct: 691  VTYIFESLMVNEFHGREFECGQYIPSGPGFE 721



 Score =  119 bits (297), Expect = 8e-26
 Identities = 144/591 (24%), Positives = 245/591 (41%), Gaps = 110/591 (18%)

Query: 171  KRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEAD 230
            K+    ILD+V G +KPG++T L+GA GAGK++LL  L+ ++ + +   G    NGH  D
Sbjct: 869  KKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALD 928

Query: 231  EFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSP 290
              F +R+  Y+ Q D H    TVRE L F+A  +                          
Sbjct: 929  SSF-QRSIGYVQQQDVHLETTTVREALQFSAYLR-------------------------- 961

Query: 291  EIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMI 349
                  +++ +  K+     DY++ +L +   ++ +VG     G++  QRKR+T G E++
Sbjct: 962  ------QSNKISKKEKDDYVDYVIDLLEMTDYADALVGV-AGEGLNVEQRKRLTIGVELV 1014

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
              P+  LF+DE ++GLDS T + I K ++       A +L  + QP+      FD L+ L
Sbjct: 1015 AKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQA-ILCTIHQPSALIMAEFDKLLFL 1073

Query: 410  SE-GHVIYEGPR----ENVLEFFESIGF-KLPPRKGIADFLQEV-------SSRKDQAQY 456
             + G   Y G      + ++ +FE  G    P     A+++ +V        +++D  + 
Sbjct: 1074 QKGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEV 1133

Query: 457  WADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEIS 516
            W + S +YQ V                    L   P D     P AL   KYA   W   
Sbjct: 1134 WRN-SSEYQAV----------REEINRMEAELSKLPRDND---PEAL--LKYAAPLW--- 1174

Query: 517  KACFAREALLISRQRFLYIFKTCQVAF---VGFVTCTIFLRTRMHPTDEAYGNLYVSALF 573
                 ++ LL+S +  +  +++    +   +  ++ ++F+      +      L    L 
Sbjct: 1175 -----KQYLLVSWRTIVQDWRSPGYIYSKLILVISSSLFIGFSFFKSKNNLQGLQSQML- 1228

Query: 574  FGLVHMMFNGFSELSLMIARLPVFYKQR--------DNLFYPAWAWSLTNWVLRVPYSII 625
               V M F  F+  + +   LP F K R         +  +  +A+        +P+ I+
Sbjct: 1229 --AVFMFFVPFT--TFIDQMLPYFVKHRAVYEVREAPSRTFSWFAFIAGQITSEIPFQIV 1284

Query: 626  EAVIWTVIVYYTVGFAPSA---------GRFFRYMFILF-----VMHQMAIGLFRMMASI 671
               I     YY VG   +A         G     +   F      M Q+AI L  ++ + 
Sbjct: 1285 VGTISYFCWYYPVGLYANAEPTDSVNSRGVLMWMLLTAFYVYTSTMGQLAISLNELIDNA 1344

Query: 672  ARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAI 722
            A    LA T  +  L+   +L G      +I  +WI+ Y  +P TY  +AI
Sbjct: 1345 AN---LATTLFTLCLMFCGVLAG----PNVIPGFWIFMYRCNPFTYLIQAI 1388


>PDRA_YEAST (P51533) ATP-dependent permease PDR10
          Length = 1564

 Score =  435 bits (1118), Expect = e-121
 Identities = 355/1331 (26%), Positives = 602/1331 (44%), Gaps = 195/1331 (14%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDS-NLKKTGSITYNGHEADEF--F 233
            IL  + G I PG + ++LG PGAG ++LL +++       +     ITYNG    E    
Sbjct: 195  ILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHGFKISPDTIITYNGFSNKEIKNH 254

Query: 234  VKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEID 293
             +    Y +++D H   LTV +TL               YT  + RL+  RN     + D
Sbjct: 255  YRGEVVYNAESDIHIPHLTVFQTL---------------YT--VARLKTPRNRIKGVDRD 297

Query: 294  AFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPR 353
             F K            T+  +   GL   ++T VG+D +RGVSGG+RKRV+  E+ +   
Sbjct: 298  TFAKHM----------TEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGS 347

Query: 354  KTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGH 413
            K    D  + GLDS+T  + +K +K    +  +   +A+ Q + + ++LFD + +L +G+
Sbjct: 348  KFQCWDNATRGLDSATALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGY 407

Query: 414  VIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQA------------------- 454
             I+ GP +   ++F+ +G+  P R+  AD+L  ++S  ++                    
Sbjct: 408  QIFFGPSKQAKKYFQRMGYVCPERQTTADYLTSITSPSERIKDKDMVKHGIMIPQTAYEM 467

Query: 455  -QYW--ADPSKQYQF-------VPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALA 504
             QYW  ++  KQ Q          S +  E  +N+                 +  PS+  
Sbjct: 468  NQYWIQSEEYKQLQVQVNKHLDTDSSQQREQIKNAHIAK----------QSKRARPSS-- 515

Query: 505  RTKYAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAY 564
               Y VS +   K    R+   I     + +F     A +  +  ++F    +  T   +
Sbjct: 516  --PYTVSFFLQVKYILIRDIWRIKNDPSIQLFTVLSHAAMALILGSMFYEVMLSTTTTTF 573

Query: 565  GNLYVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSI 624
                 +A+FF ++   F+   E+  +    P+  K +    Y   A +  +    VP  +
Sbjct: 574  -YYRGAAIFFAILFNAFSSLLEIFSLYETRPITEKHKTYSLYRPSADAFASTFSDVPTKL 632

Query: 625  IEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSA 684
              AV + +  Y+ +     AG FF Y  I  +       LFR + S+++ +  A    S 
Sbjct: 633  ATAVTFNIPYYFLINLKRDAGAFFFYFLINIITVFAMSHLFRCIGSVSKTLPQAMVPASV 692

Query: 685  ALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRW------------ 732
             LL   +  GF IP+  +  W  W  +++PL+Y   ++ +NEF    +            
Sbjct: 693  LLLAFAMYTGFAIPRVQMLGWSKWISYINPLSYLFESLMINEFHGRNFPCAQYIPSGPNY 752

Query: 733  -------MKQSALGNNTIGYNILHAQSLPSEDYWY-----WVSVAVLVTYAIIFNIMVTL 780
                   +  SALG+   G N +        +Y Y     W SV + + Y I F  +   
Sbjct: 753  VNATGDEVTCSALGSIP-GNNYVSGDDFIQTNYGYRHKNKWRSVGIGLAYIIFFLFLYLF 811

Query: 781  -------------ALAYLHPLQKPR---------------TVIPQDDEPE-----KSSSR 807
                          L + H + K                 T+   D E +      SS+ 
Sbjct: 812  FCEYNEGAKQNGEMLVFPHSVVKKMKKKGIVSEKKKKNQPTLSTSDAEKDVEMNNNSSAT 871

Query: 808  DANYVF---------------------STRSTKDESNTKGMILPFQPLTMTFHNVSYFVD 846
            D+ ++                      S+ +++  S +K   +        FH  +   D
Sbjct: 872  DSRFLRDSDAAIMGNDKTVAKEHYSSPSSSASQSNSFSKSDDIELSKSQAIFHWKNLCYD 931

Query: 847  MPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGD 906
            +P       I   + ++L NV G   PG LTAL+G+SGAGKTTL+D LA R T G I GD
Sbjct: 932  IP-------IKNGKRRILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGLITGD 984

Query: 907  IKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQV 966
            + + G P++Q +F R  GY +Q D+H    T+ ESL FSA LR   ++S ++K ++VE+V
Sbjct: 985  VFVDGRPRDQ-SFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQADDVSIEEKDKYVEEV 1043

Query: 967  MKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSI-IFMDEPTSGLDARAAAI 1025
            ++++E+    +A+VG+PG  GL+ EQRKRLTI VEL A P + +F+DEPTSGLD++ A  
Sbjct: 1044 IEVLEMKLYADAIVGVPGE-GLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWS 1102

Query: 1026 VMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQ 1085
              + ++     G+ ++CTIHQPS  + + FD LL ++ GG+ +Y G+LG   + MI+YF+
Sbjct: 1103 TCQLMKKLASRGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGELGKGCKTMINYFE 1162

Query: 1086 GIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYNNSDQYRGVEASI--LEFEHP- 1142
               G    P   NPA W+LE+   +       D+  I+ +S++YR ++  +  +E E P 
Sbjct: 1163 A-HGAHKCPPDANPAEWMLEIVGAAPGTHASQDYFAIWRDSEEYREMQKELDWMERELPK 1221

Query: 1143 ----PAGSEPLKF--DTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISALVFG 1196
                 +  E  +F   T+Y   L+S  YR   +    YWR+P Y   + + T +S L  G
Sbjct: 1222 RTEGSSNEEQKEFATSTLYQIKLVS--YRLFHQ----YWRTPFYLWSKFFSTIVSELFIG 1275

Query: 1197 TVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQ--PIVSIERTVF-YREKAAGM 1253
              F+      +S Q L   M A++   +F  V N    Q  P+   +R ++  RE+ +  
Sbjct: 1276 FTFF---KANTSLQGLQNQMLAIF---MFTVVFNPILQQYLPLFVQQRELYEARERPSRT 1329

Query: 1254 YSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAG-------KFFLYLLFMFLTF 1306
            +S  A+ V+Q L+EIP+  +   +   + Y+ + F R A        +  L+ LF    +
Sbjct: 1330 FSWKAFIVSQILVEIPWNLLAGTIAFFVYYYPVGFYRNASYANQLHERGALFWLFACAFY 1389

Query: 1307 TYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQWT 1366
             Y +  G++ +        AA ++S F+ +     G L   + +P +WI+ Y + P+ + 
Sbjct: 1390 VYISSMGVLVISCIEIAENAANLASLFFIMSLSFCGVLATPNILPRFWIFMYRVSPLTYL 1449

Query: 1367 LRGVITSQLGD 1377
            +  +++  L +
Sbjct: 1450 IDALLSVGLAN 1460



 Score =  141 bits (356), Expect = 1e-32
 Identities = 151/642 (23%), Positives = 271/642 (41%), Gaps = 86/642 (13%)

Query: 858  ETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGD--IKISGYPKE 915
            ++  Q+L  + G  +PG L  ++G  GAG TTL+  ++    G  I  D  I  +G+  +
Sbjct: 190  DSGFQILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHGFKISPDTIITYNGFSNK 249

Query: 916  Q--RTFARISGYVEQNDIHSPQVTIEESLWFSASLRLP----KEISTDK-KREFVEQVMK 968
            +    +     Y  ++DIH P +T+ ++L+  A L+ P    K +  D   +   E  M 
Sbjct: 250  EIKNHYRGEVVYNAESDIHIPHLTVFQTLYTVARLKTPRNRIKGVDRDTFAKHMTEVAMA 309

Query: 969  LVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMR 1028
               L    +  VG     G+S  +RKR++IA   +        D  T GLD+  A   ++
Sbjct: 310  TYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIK 369

Query: 1029 AVRNTVD-TGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGI 1087
            A++     T       I+Q S D ++ FD + ++  G ++ +G      S+    YFQ +
Sbjct: 370  ALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGYQIFFG-----PSKQAKKYFQRM 424

Query: 1088 RGIRPIPRGYNPATWVLEVTTPSVEETIDADFA--------------EIYNNSDQYRGVE 1133
              +   P     A ++  +T+PS E   D D                + +  S++Y+ ++
Sbjct: 425  GYV--CPERQTTADYLTSITSPS-ERIKDKDMVKHGIMIPQTAYEMNQYWIQSEEYKQLQ 481

Query: 1134 ASI--------------LEFEHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPP 1179
              +              ++  H    S+  +  + Y+ S   Q    L +     WR   
Sbjct: 482  VQVNKHLDTDSSQQREQIKNAHIAKQSKRARPSSPYTVSFFLQVKYILIRD---IWRIKN 538

Query: 1180 YNAMRMYFTTIS----ALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQ 1235
              ++++ FT +S    AL+ G++F+++    ++T   Y    A++ + LF   N  S++ 
Sbjct: 539  DPSIQL-FTVLSHAAMALILGSMFYEV-MLSTTTTTFYYRGAAIFFAILF---NAFSSLL 593

Query: 1236 PIVSIERT--VFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAG 1293
             I S+  T  +  + K   +Y P A A A    ++P     A+ F +  YF+IN +R AG
Sbjct: 594  EIFSLYETRPITEKHKTYSLYRPSADAFASTFSDVPTKLATAVTFNIPYYFLINLKRDAG 653

Query: 1294 KFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGW 1353
             FF Y L   +T    +        +S T   A V +S     + + +GF IP   + GW
Sbjct: 654  AFFFYFLINIITVFAMSHLFRCIGSVSKTLPQAMVPASVLLLAFAMYTGFAIPRVQMLGW 713

Query: 1354 WIWFYYICPVQWTLRGVITSQL----------------------GDVETKIIG--PGFE- 1388
              W  YI P+ +    ++ ++                        +V    +G  PG   
Sbjct: 714  SKWISYINPLSYLFESLMINEFHGRNFPCAQYIPSGPNYVNATGDEVTCSALGSIPGNNY 773

Query: 1389 GTVKEYLSLNLGYDPKIMGIST-VGLSVIVLFGFIILFFCSF 1429
             +  +++  N GY  K    S  +GL+ I+ F F+ LFFC +
Sbjct: 774  VSGDDFIQTNYGYRHKNKWRSVGIGLAYIIFFLFLYLFFCEY 815



 Score =  118 bits (295), Expect = 1e-25
 Identities = 146/598 (24%), Positives = 254/598 (42%), Gaps = 114/598 (19%)

Query: 159  ETICTNLGIYRPKRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKK 218
            + +C ++ I   KR    ILDNV G +KPG +T L+GA GAGK++LL  LA +    L  
Sbjct: 926  KNLCYDIPIKNGKRR---ILDNVDGWVKPGTLTALIGASGAGKTTLLDCLAERTTMGL-I 981

Query: 219  TGSITYNGHEADEFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIG 278
            TG +  +G   D+ F  R+  Y  Q D H    TVRE+L F+A  + A         D+ 
Sbjct: 982  TGDVFVDGRPRDQSF-PRSIGYCQQQDLHLKTATVRESLRFSAYLRQAD--------DVS 1032

Query: 279  RLENERNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGG 338
              E ++ +                        + +++VL + + ++ IVG     G++  
Sbjct: 1033 IEEKDKYV------------------------EEVIEVLEMKLYADAIVGVPG-EGLNVE 1067

Query: 339  QRKRVTTG-EMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAP 397
            QRKR+T G E+   P+  +F+DE ++GLDS T +   + +K       A +L  + QP+ 
Sbjct: 1068 QRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWSTCQLMKKLASRGQA-ILCTIHQPSA 1126

Query: 398  ETFELFDDLVLLSE-GHVIYEGPR----ENVLEFFESIG-FKLPPRKGIADFLQEV---- 447
               + FD L+ L E G  +Y G      + ++ +FE+ G  K PP    A+++ E+    
Sbjct: 1127 LLMQEFDRLLFLQEGGQTVYFGELGKGCKTMINYFEAHGAHKCPPDANPAEWMLEIVGAA 1186

Query: 448  ---SSRKDQAQYWADPSKQYQFVPSGEIAEAFRNSRF-GSYVESLQTHPYDKSKCHPSAL 503
                + +D    W D  +  +     +  E     R  GS  E       ++ +   S L
Sbjct: 1187 PGTHASQDYFAIWRDSEEYREMQKELDWMERELPKRTEGSSNE-------EQKEFATSTL 1239

Query: 504  ARTKYAVSRWEISKACFAREALLISRQRFLYIFKT---CQVAFVGFVTCTIFLRTRMHPT 560
             + K                  L+S + F   ++T       F   +   +F+       
Sbjct: 1240 YQIK------------------LVSYRLFHQYWRTPFYLWSKFFSTIVSELFIGFTFFKA 1281

Query: 561  DEAYGNLYVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPA---------W-A 610
            + +   L    L   +  ++FN      ++   LP+F +QR+   Y A         W A
Sbjct: 1282 NTSLQGLQNQMLAIFMFTVVFN-----PILQQYLPLFVQQRE--LYEARERPSRTFSWKA 1334

Query: 611  WSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSA---------GRFFRYMFILFVMHQMA 661
            + ++  ++ +P++++   I   + YY VGF  +A         G  F      F ++  +
Sbjct: 1335 FIVSQILVEIPWNLLAGTIAFFVYYYPVGFYRNASYANQLHERGALFWLFACAFYVYISS 1394

Query: 662  IGLFRMMASIARDMVLANTFGSAALLVIFLLG--GFIIPKGMIKPWWIWGYWLSPLTY 717
            +G+      I+   +  N    A+L  I  L   G +    ++  +WI+ Y +SPLTY
Sbjct: 1395 MGVL----VISCIEIAENAANLASLFFIMSLSFCGVLATPNILPRFWIFMYRVSPLTY 1448


>PDRC_YEAST (Q02785) ATP-dependent permease PDR12
          Length = 1511

 Score =  427 bits (1098), Expect = e-118
 Identities = 364/1379 (26%), Positives = 620/1379 (44%), Gaps = 137/1379 (9%)

Query: 103  DQDNYRLLSAIKERLDRIGIEVPNIEVRFSNLSVSADVQIGSRALPTLINYTRDALETIC 162
            D D   LL  ++ R    GIE  +  + F NL+ +  V   +   P++    R+ + +I 
Sbjct: 88   DFDLRSLLHYLRSRQLEQGIEPGDSGIAFKNLT-AVGVDASAAYGPSVEEMFRN-IASIP 145

Query: 163  TNLGIYRPKRHSL---TILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKT 219
             +L     K+  +    I+ N +GV++ G M  ++G PGAG S+ L  L+G+    +   
Sbjct: 146  AHLISKFTKKSDVPLRNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSGETSELVDVQ 205

Query: 220  GSITYNGHEADEFFVKRT--CAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDI 277
            G  +Y+G +  E   K      Y  + D H  ++TV+ET+DFA +C+             
Sbjct: 206  GEFSYDGLDQSEMMSKYKGYVIYCPELDFHFPKITVKETIDFALKCK------------- 252

Query: 278  GRLENERNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSG 337
                      P   ID   +   V   +     D    V GL     T VG+D +RGVSG
Sbjct: 253  ---------TPRVRIDKMTRKQYVDNIR-----DMWCTVFGLRHTYATKVGNDFVRGVSG 298

Query: 338  GQRKRVTTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAP 397
            G+RKRV+  E           D  + GLD+ST  +  + I+   ++++ + ++A+ Q   
Sbjct: 299  GERKRVSLVEAQAMNASIYSWDNATRGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGE 358

Query: 398  ETFELFDDLVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQYW 457
              +ELFD   +L  G  IY GP +  + +F+ +G+  P R   A+FL  V+   +     
Sbjct: 359  NIYELFDKTTVLYNGRQIYFGPADKAVGYFQRMGWVKPNRMTSAEFLTSVTVDFENRTLD 418

Query: 458  ADPSKQYQFVP--SGEIAEAFRNSRFGSYVESLQT-------HPYD----------KSKC 498
              P  + + VP  S E  E + NS    Y E L+T       HP +          K + 
Sbjct: 419  IKPGYEDK-VPKSSSEFEEYWLNSE--DYQELLRTYDDYQSRHPVNETRDRLDVAKKQRL 475

Query: 499  HPSALARTKYAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMH 558
                   ++Y V+ W     C  R       QR        +V    F+   + + +  H
Sbjct: 476  QQGQRENSQYVVNYWTQVYYCMIR-----GFQRVKGDSTYTKVYLSSFLIKALIIGSMFH 530

Query: 559  PTDEAYGNLYVSA------LFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWS 612
              D+   +    A      LF+ L+       +E+    +  PV  K +    Y   A S
Sbjct: 531  KIDDKSQSTTAGAYSRGGMLFYVLLFASVTSLAEIGNSFSSRPVIVKHKSYSMYHLSAES 590

Query: 613  LTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIA 672
            L   +   P   +  VI  +I Y+       AG FF+Y+  L  + Q    +F+ +A+++
Sbjct: 591  LQEIITEFPTKFVAIVILCLITYWIPFMKYEAGAFFQYILYLLTVQQCTSFIFKFVATMS 650

Query: 673  RDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRW 732
            +  V A+  G   +L++ +  GF++P G +  W  W ++++PLTY   ++   EF   R 
Sbjct: 651  KSGVDAHAVGGLWVLMLCVYAGFVLPIGEMHHWIRWLHFINPLTYAFESLVSTEFH-HRE 709

Query: 733  MKQSALGNNTIGYN--------------------------ILHAQSLPSEDYWYWVSVAV 766
            M  SAL  +  GY                           ILH      +  W    V +
Sbjct: 710  MLCSALVPSGPGYEGISIANQVCDAAGAVKGNLYVSGDSYILHQYHFAYKHAWRNWGVNI 769

Query: 767  LVTYA-IIFNIMVTLALAYLHPLQKPRTVI--PQDDEPEKSSSRDANYVFSTRSTKDESN 823
            + T+  I+FN++++    YL P++    ++   +   PE  +        S     +  N
Sbjct: 770  VWTFGYIVFNVILS---EYLKPVEGGGDLLLYKRGHMPELGTENADARTASREEMMEALN 826

Query: 824  TKGMILP---FQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALV 880
               + L     +    T++++ Y +      RK         LLS+V G   PG +TAL+
Sbjct: 827  GPNVDLEKVIAEKDVFTWNHLDYTIPYDGATRK---------LLSDVFGYVKPGKMTALM 877

Query: 881  GSSGAGKTTLMDVLAGRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEE 940
            G SGAGKTTL++VLA R   G I GD+ ++  P    +F R  GYV Q D H  ++++ E
Sbjct: 878  GESGAGKTTLLNVLAQRINMGVITGDMLVNAKPLPA-SFNRSCGYVAQADNHMAELSVRE 936

Query: 941  SLWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAV 1000
            SL F+A LR    +  ++K E+VE+++ L+ + +   ALVG  G  GL+ EQRK+L+I V
Sbjct: 937  SLRFAAELRQQSSVPLEEKYEYVEKIITLLGMQNYAEALVGKTGR-GLNVEQRKKLSIGV 995

Query: 1001 ELVANPSII-FMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLL 1059
            ELVA PS++ F+DEPTSGLD+++A  +++ +R   D+G++++CTIHQPS  +FE FD LL
Sbjct: 996  ELVAKPSLLLFLDEPTSGLDSQSAWSIVQFMRALADSGQSILCTIHQPSATLFEQFDRLL 1055

Query: 1060 LMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADF 1119
            L+K+GG+++Y G +G  S+ ++ YF+   G++      NPA ++L         ++++D+
Sbjct: 1056 LLKKGGKMVYFGDIGPNSETLLKYFERQSGMK-CGVSENPAEYILNCIGAGATASVNSDW 1114

Query: 1120 AEIYNNSDQYRGVEASILEFEHPPAG---SEPLKFDTIYSQSLLSQFYRCLWKQNLVYWR 1176
             +++  S +     A + E      G   ++  +  T ++ S ++Q    L +  L +WR
Sbjct: 1115 HDLWLASPECAAARAEVEELHRTLPGRAVNDDPELATRFAASYMTQIKCVLRRTALQFWR 1174

Query: 1177 SPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQP 1236
            SP Y   + +     AL  G  +  +        E +  +  L    L I +   + +  
Sbjct: 1175 SPVYIRAKFFECVACALFVGLSYVGVNHSVGGAIEAFSSIFML----LLIALAMINQLHV 1230

Query: 1237 IVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKF 1295
                 R ++  RE A+  +      +    +E  +  +   +  +  Y+   F   A   
Sbjct: 1231 FAYDSRELYEVREAASNTFHWSVLLLCHAAVENFWSTLCQFMCFICYYWPAQFSGRASHA 1290

Query: 1296 FLYLLFMFLTF-TYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWW 1354
              +  F  L F  YF  YG+  + +SP    A++I+S  ++   L  G L P   +P +W
Sbjct: 1291 GFFFFFYVLIFPLYFVTYGLWILYMSPDVPSASMINSNLFAAMLLFCGILQPREKMPAFW 1350

Query: 1355 -IWFYYICPVQWTLRGVITSQLGDV-------ETKIIGPGFEGTVKEYLSL----NLGY 1401
                Y + P  + ++ ++T  + +        E  I+ P    T  E+LS     N GY
Sbjct: 1351 RRLMYNVSPFTYVVQALVTPLVHNKKVVCNPHEYNIMDPPSGKTCGEFLSTYMDNNTGY 1409


>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
          Length = 1501

 Score =  427 bits (1097), Expect = e-118
 Identities = 346/1293 (26%), Positives = 599/1293 (45%), Gaps = 148/1293 (11%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALA-GKLDSNLKKTGSITYNG---HEADEF 232
            IL ++  +++PG +T++LG PGAG S+LL  +A      ++ K   ITY+G   H+ +  
Sbjct: 169  ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 228

Query: 233  FVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEI 292
            + +    Y ++TD H   L+V +TL+FAAR +  Q       ++                
Sbjct: 229  Y-RGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYA------------- 274

Query: 293  DAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGP 352
                        KH  +    +   GL     T VG+D +RGVSGG+RKRV+  E  +  
Sbjct: 275  ------------KHMASV--YMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSG 320

Query: 353  RKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEG 412
                  D  + GLDS+T  + ++ +K    ++D T L+A+ Q + + ++LFD +V+L EG
Sbjct: 321  ANIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEG 380

Query: 413  HVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQ----------------- 455
            + I+ G      E+FE +G+K P R+  ADFL  +++  ++                   
Sbjct: 381  YQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFET 440

Query: 456  YWADPSKQYQFVPSGEIAEAF----RNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVS 511
            YW +  +  +     EI E F    R++   +Y ES        +K   +    + Y VS
Sbjct: 441  YWKNSPEYAELTK--EIDEYFVECERSNTRETYRES------HVAKQSNNTRPASPYTVS 492

Query: 512  RWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYV-- 569
             +   +   AR  L +     + IF       +G +  ++F     +   +  G+ Y   
Sbjct: 493  FFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVF-----YNLSQTTGSFYYRG 547

Query: 570  SALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVI 629
            +A+FF ++   F+   E+  +    P+  K +    Y   A +L + +  +P  +  ++ 
Sbjct: 548  AAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADALASIISELPVKLAMSMS 607

Query: 630  WTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVI 689
            +  + Y+ V F  + GRFF Y  +      +   LFR + +++  +  A T  +  LL +
Sbjct: 608  FNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMSHLFRSIGAVSTSISGAMTPATVLLLAM 667

Query: 690  FLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMKQSALGNNTIGYNILH 749
             +  GF+IP   +  W  W  +++P+ Y   ++ VNEF    +     + +     NI  
Sbjct: 668  VIYTGFVIPTPSMLGWSRWINYINPVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISR 727

Query: 750  AQ-------SLPSED-----------YWY-----WVSVAVLVTYAIIFNIMVTLALAYLH 786
            +        S+P  +           Y Y     W ++ + + +A+ F + + +AL   +
Sbjct: 728  SNQVCTAVGSVPGNEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFF-LAIYIALTEFN 786

Query: 787  P--LQKPRTVIPQDDEPEKSSSRDA----------------NYVFSTRSTKDES-----N 823
               +QK   V+      +K   + A                +Y     +  +E      +
Sbjct: 787  KGAMQKGEIVLFLKGSLKKHKRKTAASNKGDIEAGPVAGKLDYQDEAEAVNNEKFTEKGS 846

Query: 824  TKGMILPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSS 883
            T  +  P       + +++Y V + +E R          +L +V G   PG +TAL+G+S
Sbjct: 847  TGSVDFPENREIFFWRDLTYQVKIKKEDRV---------ILDHVDGWVKPGQITALMGAS 897

Query: 884  GAGKTTLMDVLAGRKTGGYI-EGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESL 942
            GAGKTTL++ L+ R T G I +G+  ++G+  +  +F R  GYV+Q D+H P  T+ E+L
Sbjct: 898  GAGKTTLLNCLSERVTTGIITDGERLVNGHALDS-SFQRSIGYVQQQDVHLPTSTVREAL 956

Query: 943  WFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVEL 1002
             FSA LR   +IS  +K ++V+ V+ L+E+    +ALVG+ G  GL+ EQRKRLTI VEL
Sbjct: 957  QFSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVEL 1015

Query: 1003 VANPS-IIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLM 1061
            VA P  ++F+DEPTSGLD++ A  + + +R   D G+ ++CTIHQPS  I   FD LL +
Sbjct: 1016 VAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFL 1075

Query: 1062 KRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAE 1121
            ++GGR  Y G+LG   Q MI+YF+   G  P P+  NPA W+L+V   +       D+ E
Sbjct: 1076 QKGGRTAYFGELGENCQTMINYFEKY-GADPCPKEANPAEWMLQVVGAAPGSHAKQDYFE 1134

Query: 1122 IYNNSDQYRGVEASI----LEFEHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRS 1177
            ++ NS +Y+ V   I     E    P  ++P      Y+  L  Q+    W+  +  WRS
Sbjct: 1135 VWRNSSEYQAVREEINRMEAELSKLPRDNDPEAL-LKYAAPLWKQYLLVSWRTIVQDWRS 1193

Query: 1178 PPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNN-ASTVQP 1236
            P Y   +++    +AL  G  F+     +++ Q L   M +++    FI  N     + P
Sbjct: 1194 PGYIYSKIFLVVSAALFNGFSFF---KAKNNMQGLQNQMFSVF--MFFIPFNTLVQQMLP 1248

Query: 1237 IVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKF 1295
                +R V+  RE  +  +S  A+   Q   EIPY      +     Y+ +     A   
Sbjct: 1249 YFVKQRDVYEVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNATPT 1308

Query: 1296 FL-----YLLFMFLT--FTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPES 1348
                    L++M +T  + Y    G + +  S     AA +++  +++     G L    
Sbjct: 1309 DSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTMCLNFCGVLAGPD 1368

Query: 1349 HIPGWWIWFYYICPVQWTLRGVITSQLGDVETK 1381
             +PG+WI+ Y   P  + ++ ++++ L +   K
Sbjct: 1369 VLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVK 1401



 Score =  150 bits (380), Expect = 2e-35
 Identities = 141/572 (24%), Positives = 250/572 (43%), Gaps = 63/572 (11%)

Query: 863  LLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYI--EGDIKISGYPKE--QRT 918
            +L ++  +  PG LT ++G  GAG +TL+  +A    G +I  E  I   G      +R 
Sbjct: 169  ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 228

Query: 919  FARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVE-----LD 973
            +     Y  + D+H P +++ ++L F+A LR P+       RE   + M  V      L 
Sbjct: 229  YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATYGLS 288

Query: 974  SLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRNT 1033
              RN  VG     G+S  +RKR++IA   ++  +I   D  T GLD+  A   +RA++ +
Sbjct: 289  HTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKTS 348

Query: 1034 -VDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRP 1092
             V    T +  I+Q S D ++ FD ++++  G ++ +G     +     +YF+ +     
Sbjct: 349  AVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQIFFGKATKAK-----EYFEKMGW--K 401

Query: 1093 IPRGYNPATWVLEVTTPSVEETIDA----------DFAEIYNNSDQYRGVEASILEF--- 1139
             P+    A ++  +T P+  E +            +F   + NS +Y  +   I E+   
Sbjct: 402  CPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVE 461

Query: 1140 ------------EHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYF 1187
                         H    S   +  + Y+ S   Q    + +  L     P      ++ 
Sbjct: 462  CERSNTRETYRESHVAKQSNNTRPASPYTVSFFMQVRYGVARNFLRMKGDPSIPIFSVFG 521

Query: 1188 TTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIVSI--ERTVF 1245
              +  L+  +VF+++     +T   Y    A++ + LF   N  S++  I+S+   R + 
Sbjct: 522  QLVMGLILSSVFYNLSQ---TTGSFYYRGAAMFFAVLF---NAFSSLLEIMSLFEARPIV 575

Query: 1246 YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKFFLY-LLFMFL 1304
             + K   +Y P A A+A  + E+P     +M F  + YFM+NF R  G+FF Y L+ ++ 
Sbjct: 576  EKHKKYALYRPSADALASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWC 635

Query: 1305 TFT---YFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYIC 1361
            TF     F   G ++  +S     A V+  A      + +GF+IP   + GW  W  YI 
Sbjct: 636  TFVMSHLFRSIGAVSTSISGAMTPATVLLLAMV----IYTGFVIPTPSMLGWSRWINYIN 691

Query: 1362 PVQWTLRGVITSQLGDVETKII-----GPGFE 1388
            PV +    ++ ++    E +       GPG+E
Sbjct: 692  PVGYVFESLMVNEFHGREFQCAQYVPSGPGYE 723



 Score =  121 bits (303), Expect = 2e-26
 Identities = 146/591 (24%), Positives = 240/591 (39%), Gaps = 120/591 (20%)

Query: 171  KRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEAD 230
            K+    ILD+V G +KPG++T L+GA GAGK++LL  L+ ++ + +   G    NGH  D
Sbjct: 871  KKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALD 930

Query: 231  EFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSP 290
              F +R+  Y+ Q D H    TVRE L F+A  +                          
Sbjct: 931  SSF-QRSIGYVQQQDVHLPTSTVREALQFSAYLR-------------------------- 963

Query: 291  EIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMI 349
                  +++ +  K+     DY++ +L +   ++ +VG     G++  QRKR+T G E++
Sbjct: 964  ------QSNKISKKEKDDYVDYVIDLLEMTDYADALVGV-AGEGLNVEQRKRLTIGVELV 1016

Query: 350  VGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLL 409
              P+  LF+DE ++GLDS T + I K ++       A +L  + QP+      FD L+ L
Sbjct: 1017 AKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQA-ILCTIHQPSALIMAEFDRLLFL 1075

Query: 410  SE-GHVIYEGPR----ENVLEFFESIGF-KLPPRKGIADFLQEV-------SSRKDQAQY 456
             + G   Y G      + ++ +FE  G    P     A+++ +V        +++D  + 
Sbjct: 1076 QKGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEV 1135

Query: 457  WADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEIS 516
            W + S +YQ V                    L   P D     P AL   KYA   W   
Sbjct: 1136 WRN-SSEYQAV----------REEINRMEAELSKLPRDND---PEAL--LKYAAPLW--- 1176

Query: 517  KACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFF-- 574
                 ++ LL+S +  +  +++      G++   IFL             L+    FF  
Sbjct: 1177 -----KQYLLVSWRTIVQDWRS-----PGYIYSKIFL--------VVSAALFNGFSFFKA 1218

Query: 575  -----GLVHMMFNGFSEL----SLMIARLPVFYKQRD--------NLFYPAWAWSLTNWV 617
                 GL + MF+ F       +L+   LP F KQRD        +  +  +A+      
Sbjct: 1219 KNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDVYEVREAPSRTFSWFAFIAGQIT 1278

Query: 618  LRVPYSIIEAVIWTVIVYYTVGFAPSA---------GRFFRYMFILFVMHQMAIGLFRMM 668
              +PY +    I     YY +G   +A         G     +   F ++   +G   M 
Sbjct: 1279 SEIPYQVAVGTIAFFCWYYPLGLYNNATPTDSVNPRGVLMWMLVTAFYVYTATMGQLCMS 1338

Query: 669  ASIARDMVLANTFGSAALLVIFLLG--GFIIPKGMIKPWWIWGYWLSPLTY 717
             S   D    N    A LL    L   G +    ++  +WI+ Y  +P TY
Sbjct: 1339 FSELAD----NAANLATLLFTMCLNFCGVLAGPDVLPGFWIFMYRCNPFTY 1385


>CDR4_CANAL (O74676) ABC transporter CDR4
          Length = 1490

 Score =  417 bits (1073), Expect = e-116
 Identities = 352/1352 (26%), Positives = 622/1352 (45%), Gaps = 151/1352 (11%)

Query: 104  QDNYRLLSAIKERLDRIGIEVPNIEVRFSNLSVSADVQIGSRALPTLINYTRDALETICT 163
            Q+ ++L+S+  +    + I V    +R    +  AD Q       TL+N     L     
Sbjct: 106  QNAHKLVSSDIDYFKPVTIGVAYKNLRAYGSASDADYQ------STLVNLIPKYLSLFFR 159

Query: 164  NLGIYRPKRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDS-NLKKTGSI 222
               I R    +  IL  + G+IKPG +T++LG PGAG S+ L  +A +    ++ K   I
Sbjct: 160  EY-ILRHTGPTFDILKPMDGLIKPGELTVVLGRPGAGCSTFLKTIASQTYGYHIDKDSVI 218

Query: 223  TYNG---HEADEFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGR 279
             YN    HE  + + +    Y ++T+NH  +LTV +TL+FAA+ +  Q      ++D   
Sbjct: 219  RYNSLTPHEIKKHY-RGEVVYCAETENHFPQLTVGDTLEFAAKMRTPQNRPLGVSRD--- 274

Query: 280  LENERNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQ 339
                          A+ +  +            ++ V GL     T VG+D +RGVSGG+
Sbjct: 275  --------------AYARHLAA----------VVMAVYGLSHTRNTKVGNDFIRGVSGGE 310

Query: 340  RKRVTTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPET 399
            RKRV+  E+ +        D  + GLDS+T  + ++ +K    ++  T L+A+ Q + + 
Sbjct: 311  RKRVSIAEITLNNAMVQCWDNSTRGLDSATALEFIRALKASADIVHTTPLVAIYQCSQDA 370

Query: 400  FELFDDLVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQA----- 454
            ++LFD +VL+ +G+ IY G  +   ++F  +G++ P R+  ADFL  +++  ++      
Sbjct: 371  YDLFDKVVLMYQGYQIYFGSAKKAKQYFIDMGYECPQRQTTADFLTSLTNPAERIVRQGF 430

Query: 455  ------------QYWADPSKQYQFVPSGE--IAEAFRNSRFGSYVESLQTHPYDKSKCHP 500
                        +YW    +  Q V   +  + E    +   +  E+ Q    D  K   
Sbjct: 431  EGKVPQTPQEFYEYWKKSPEGQQIVADVDQYLTEHSSAAEKEAIKEAHQARQSDHLK--- 487

Query: 501  SALARTKYAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPT 560
                 + Y VS +   +    R  L I     +++F+      + F+  +IF      PT
Sbjct: 488  ---PASPYTVSFFMQVRYIAHRNILRIKGNPSIHLFQIFGNIGMSFILSSIFYNL---PT 541

Query: 561  DEAYGNLYVSALFFGLVHMMFNGFSEL----SLMIARLPVFYKQRDNLFYPAWAWSLTNW 616
              +      +ALFF +   +FN FS L    SL  AR  V   ++  L++PA A +  + 
Sbjct: 542  ATSSFYHRTAALFFAV---LFNAFSCLLEIFSLYEARSIVEKHKKYALYHPA-ADAFASI 597

Query: 617  VLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMV 676
            V  +P   I A+ + ++ Y+ V F  + G FF Y+ I F        +FR + +  + + 
Sbjct: 598  VTELPTKFIIAIGFNLVYYFMVNFRRTPGNFFFYLLINFSATLAMSHIFRTIGAATKTLQ 657

Query: 677  LANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEF-----TASR 731
             A T  +  LL + +  GF+IP   +  W  W  +L PL Y   ++  NEF       S+
Sbjct: 658  EAMTPAAILLLALTIFTGFVIPTPNMHGWCRWINYLDPLAYAFESLIANEFHNRDFECSQ 717

Query: 732  WMKQSALGNNTIGYNILHAQ--SLPSEDY----------------WYWVSVAVLVTYAII 773
            ++        T G N +     S+P +D+                  W +  +++ + + 
Sbjct: 718  YVPSGG-SYPTAGPNRICTPVGSVPGQDFVDGTRYMEMSFDYRNSHKWRNFGIVIGFIVF 776

Query: 774  FNIMVTLALAYLHPLQKPRTVIPQDDEPEKSSSRDANYVFSTRSTK-------DESNTKG 826
            F     L         +   ++       K   +  N + S    K       +  N + 
Sbjct: 777  FFCTYILLCEINKGAMQKGEILLFQQRALKKRKKANNDIESGEIEKVTPEFDNEYENNQD 836

Query: 827  MILPFQPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAG 886
             +L     T  + +++Y V +  E R          +L +VSG   PG +TAL+G+SGAG
Sbjct: 837  KMLQSGGDTFFWRDLTYQVKIKSEDRV---------ILDHVSGWVKPGQVTALMGASGAG 887

Query: 887  KTTLMDVLAGRKTGGYI-EGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFS 945
            KTTL++ L+ R T G + EG   ++G P +  +F R  GYV+Q D+H    T+ E+L F+
Sbjct: 888  KTTLLNALSDRLTTGVVTEGIRLVNGRPLDS-SFQRSIGYVQQQDLHLETSTVREALEFA 946

Query: 946  ASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVAN 1005
            A LR PK +S  +K E+V+ +++L+E++   +A+VG+ G  GL+ EQRKRL+I VELVA 
Sbjct: 947  AYLRQPKSVSRKEKNEYVDYIIRLLEMEQYADAVVGVSG-EGLNVEQRKRLSIGVELVAK 1005

Query: 1006 PS-IIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRG 1064
            P  ++F+DEPTSGLD++ A  + + +R   D G+ ++CTIHQPS  +   FD LL ++RG
Sbjct: 1006 PKLLVFLDEPTSGLDSQTAWSICKLIRKLADNGQAILCTIHQPSAILLAEFDRLLFLQRG 1065

Query: 1065 GRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYN 1124
            G+ +Y G LG     +I+YF+   G    P   NPA W+LEV   +     + D+ +++ 
Sbjct: 1066 GQTVYFGDLGKNFTTLINYFEKY-GAPKCPPEANPAEWMLEVIGAAPGSKANQDYYDVWL 1124

Query: 1125 NSDQYRGVEASI----LEFEHPPAGSEPLKFDTIYSQSLLSQFY---RCLWKQNLVYWRS 1177
             S +++ + + +     E    P   +P +    Y+     Q+    + +++QN   WR+
Sbjct: 1125 KSSEFQEMNSELDLMSEELVKKPLDDDPDRLKP-YAAPYWEQYLFVTKRVFEQN---WRT 1180

Query: 1178 PPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQ-- 1235
            P Y   +      S+L  G  F+       + + L  +   +++  +F+ + +    Q  
Sbjct: 1181 PSYLYSKFLLVVTSSLFNGFSFY------KADRSLQGLQNQMFSVFMFLVILHTLIQQYL 1234

Query: 1236 PIVSIERTVF-YREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTA-- 1292
            P    +R ++  RE+ +  +S I +  AQ   EIP+  +   +     Y+ +   + A  
Sbjct: 1235 PTFVSQRDLYEVRERPSKTFSWITFIAAQVTAEIPWNIICGTLGYFCWYYPVGLYQNATY 1294

Query: 1293 -------GKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLI 1345
                   G F  + + +F  F Y +    + +        AA +S   +++     G L+
Sbjct: 1295 TNTVHQRGAFMWFAIVLF--FIYTSTLAQLCISFLEIDDNAANLSVLLFTMCLAFCGVLV 1352

Query: 1346 PESHIPGWWIWFYYICPVQWTLRGVITSQLGD 1377
             +  +PG+W++ Y   P  + +  +++  L D
Sbjct: 1353 TKEQLPGFWVFMYRCSPFTYLVSVMLSVGLVD 1384


>AUS1_YEAST (Q08409) ATP-dependent permease AUS1
          Length = 1394

 Score =  321 bits (823), Expect = 8e-87
 Identities = 310/1302 (23%), Positives = 550/1302 (41%), Gaps = 169/1302 (12%)

Query: 178  LDNVSGVIKPGRMTLLLGAPGAGKSSLLLALA-GKLDSNLKKTGSITYNGHEADEFFVK- 235
            L++++   + G M L+LG P    S+L   L  GK   +    GSI +  +E   F  K 
Sbjct: 49   LNDITFQAEAGEMVLVLGYP---TSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKC 105

Query: 236  -RTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDA 294
                 Y ++ D H   LTV +T+DFA  C+           DI +               
Sbjct: 106  PHQIIYNNEQDVHFPFLTVEQTIDFALSCKF----------DIPK--------------- 140

Query: 295  FMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPRK 354
                    G++  +  + +L+  GL    +TIVG+D  RGVSGG+RKR++  E  +    
Sbjct: 141  --------GERDQIRNE-LLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGS 191

Query: 355  TLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHV 414
                D  + GLDS+T    ++ ++       +  L+ + Q + +  + FD +++LS+ + 
Sbjct: 192  VYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQ 251

Query: 415  IYEGPRENVLEFF-ESIGFKLPPRKGIADFLQEVSS----RKDQAQYWADPSKQYQFVPS 469
            ++ G  +  L +F +++G +  P   I ++L  + +     K+        S       +
Sbjct: 252  LFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTAT 311

Query: 470  GEIAEAFRNSRFGSYVESLQTHPYD--KSKCHPSALARTKYAVSRWEISKAC---FAREA 524
            GE+ +   NS F  Y +   +  Y   K +   S++  +   V   ++S        ++ 
Sbjct: 312  GEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQL 371

Query: 525  LLISRQRFLY-----IFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYV--SALFFGLV 577
            L  +++ F        + T Q  F+  V  ++ + +  +         Y   S  FF ++
Sbjct: 372  LFCTKRAFQRSLGDKAYMTAQ--FISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSIL 429

Query: 578  HMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYT 637
               F   +++ +   R PV  KQ    FY  W  +L+  V    + +   +++++I+Y+ 
Sbjct: 430  FFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFL 489

Query: 638  VGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFII 697
                  A RFF ++  L   +   + LF +   +A  + +AN F    LL I +   ++I
Sbjct: 490  AHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVI 549

Query: 698  PKGMIKPWWIWGYWLSPLTYGQRAITVNEF-------------------------TASRW 732
                + PW++W  +L+P  Y   AI  NE                           A  W
Sbjct: 550  YLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAW 609

Query: 733  MKQSALGNNTIGYNILHAQSLPSEDYWYWVSVAVLVTYAIIFNIMVTLALAYLHP----- 787
             + + LGN+ +       Q L    +  W +  +++ + + F      A  Y+ P     
Sbjct: 610  -QGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKD 668

Query: 788  --------LQKPRTVIPQDDEPEKSSSRDANYVFSTRSTKDESNTKGM-ILPF------- 831
                    L +    + +      S+  D+ YV   +S    S++  +  +P+       
Sbjct: 669  EIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNK 728

Query: 832  ---------QPLTMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGS 882
                     QP+T T     + +         G      +L++N SG  S G LTAL+G 
Sbjct: 729  EMALNDYNEQPITETVETQKHIISWKNINYTVGTK----KLINNASGFISSG-LTALMGE 783

Query: 883  SGAGKTTLMDVLAGRKTGGYIEGDIKISGYP-KEQRTFARISGYVEQNDIHSPQVTIEES 941
            SGAGKTTL++VL+ R   G + G+I I G+P  ++  F R  G+V+Q D+H   ++++ES
Sbjct: 784  SGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKES 843

Query: 942  LWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVE 1001
            L  S  LR       D  R +++ V  L++L S  + LV     + L+  QRK L+I VE
Sbjct: 844  LEISCLLR------GDGDRAYLDTVSNLLKLPS--DILV-----ADLNPTQRKLLSIGVE 890

Query: 1002 LVANPS-IIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLL 1060
            LV  PS ++F+DEPTSGLDA AA  +++ ++     G+ + CTIHQPS  +   FD++ L
Sbjct: 891  LVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFL 950

Query: 1061 MKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGY-NPATWVLEVTTPS--------V 1111
            +KRGG  ++ G +         YF          + + NPA +V++    S         
Sbjct: 951  LKRGGECVFFGPM----DDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTA 1006

Query: 1112 EETID-----ADFAEIYNNSDQYRGVEASILEFEHPPAGSEPLKFDTIYSQ-SLLSQFYR 1165
            EE +       D++ ++ +S + + V+      E     S      +++ Q S L Q   
Sbjct: 1007 EEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLAL 1066

Query: 1166 CLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQE--LYVVMGALYASC 1223
               +Q +   R   Y   +      + L  G  FW I       Q+   +  M    +S 
Sbjct: 1067 ITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSP 1126

Query: 1224 LFIGVNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITY 1283
            L   + + +     +  +     RE  +  Y      ++Q +IE+P     + +F +  +
Sbjct: 1127 LINQIQDKA-----LKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAF 1181

Query: 1284 FMINFER---TAGKFFL-YLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNL 1339
            F   F     +AG FFL Y+LF      Y++  G+  +  +P    AAV  +  YS    
Sbjct: 1182 FSCGFNNAGWSAGVFFLNYMLFA----AYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTAS 1237

Query: 1340 LSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDVETK 1381
              G + P S  P +W + Y + P  + +   ++  L + E K
Sbjct: 1238 FCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIK 1279



 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 125/573 (21%), Positives = 242/573 (41%), Gaps = 106/573 (18%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHE-ADEFFVK 235
            +++N SG I  G +T L+G  GAGK++LL  L+ ++++ +  +G I  +GH   DE   K
Sbjct: 765  LINNASGFISSG-LTALMGESGAGKTTLLNVLSQRVETGVV-SGEILIDGHPLTDEDAFK 822

Query: 236  RTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAF 295
            R+  ++ Q D H   L+V+E+L+ +   +G  +G  AY   +  L               
Sbjct: 823  RSIGFVQQQDLHLDLLSVKESLEISCLLRG--DGDRAYLDTVSNL--------------- 865

Query: 296  MKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMIVGPRK 354
                                   L + S+ +V       ++  QRK ++ G E++  P  
Sbjct: 866  -----------------------LKLPSDILVAD-----LNPTQRKLLSIGVELVTKPSL 897

Query: 355  TLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSE-GH 413
             LF+DE ++GLD+     IVK +K  + L    +   + QP+      FD++ LL   G 
Sbjct: 898  LLFLDEPTSGLDAEAALTIVKFLKQ-LSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGE 956

Query: 414  VIYEGPRENVLEFFESIGFKLPPRK---GIADFLQEV------SSRKDQAQYWADPSKQY 464
             ++ GP ++   +F S    L   K     ADF+ +       S+ KD A+     +K+ 
Sbjct: 957  CVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKE- 1015

Query: 465  QFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEISKACFAREA 524
                + + +  + +S     V+       D ++      +   Y  S W+  +  + ++ 
Sbjct: 1016 ----AIDWSALWESSVEKKLVKKETARLEDDARA-----SGVDYTTSLWK--QPSYLQQL 1064

Query: 525  LLISRQRFL-------YIF-KTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGL 576
             LI+R++++       Y+  K C     G      F   + H       +++   +   +
Sbjct: 1065 ALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIK-HNIIGLQDSIFFCFMALCV 1123

Query: 577  VHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWS---LTNWVLRVPYSIIEAVIWTVI 633
               + N   + +L    + V  + R N ++    W+   L+  ++ +P ++  + ++ V 
Sbjct: 1124 SSPLINQIQDKALKTKEVYVAREARSNTYH----WTVLLLSQSIIELPLALTSSTLFFVC 1179

Query: 634  VYYTVGF---APSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIF 690
             +++ GF     SAG FF   ++LF  +   +GL+ +          A    +AA+ V F
Sbjct: 1180 AFFSCGFNNAGWSAGVFF-LNYMLFAAYYSTLGLWLIYT--------APNLQTAAVFVAF 1230

Query: 691  LLG------GFIIPKGMIKPWWIWGYWLSPLTY 717
            +        G + P  +   +W + Y +SP TY
Sbjct: 1231 IYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTY 1263


>PDRB_YEAST (P40550) ATP-dependent permease PDR11
          Length = 1410

 Score =  301 bits (770), Expect = 1e-80
 Identities = 316/1296 (24%), Positives = 527/1296 (40%), Gaps = 171/1296 (13%)

Query: 188  GRMTLLLGAPGAGKSSLLLALA-GKLDSNLKKTGSITYNGHEADEFFVK--RTCAYISQT 244
            G + L+LG P    S+L   L  G         GSI +  +E  +F  K      Y ++ 
Sbjct: 58   GEVVLVLGNP---TSALFKGLFHGHKHLKYSPEGSIRFKDNEYKQFASKCPHQIIYNNEQ 114

Query: 245  DNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFMKASSVGGK 304
            D H   LTV +T+DFA  C+                    +I     I+           
Sbjct: 115  DIHFPYLTVEQTIDFALSCKF-------------------HIPKQERIEM---------- 145

Query: 305  KHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPRKTLFMDEISTG 364
                  D +LK  GL    +T VG+D +RGVSGG+RKR++  E  +        D  + G
Sbjct: 146  -----RDELLKEFGLSHVKKTYVGNDYVRGVSGGERKRISIIETFIANGSVYLWDNSTKG 200

Query: 365  LDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIYEGPRENVL 424
            LDS+T  + +   +       +   + + Q + +    FD +++L +   ++ G  E  L
Sbjct: 201  LDSATALEFLSITQKMAKATRSVNFVKISQASDKIVSKFDKILMLGDSFQVFYGTMEECL 260

Query: 425  -EFFESIGFKLPPRKGIADFLQEVSSRKDQAQYWADPSKQYQFVPSGEIAEAFRNSRFGS 483
              F +++  K  P   I ++L  + + K +    +        V S E      N+    
Sbjct: 261  THFHDTLQIKKNPNDCIIEYLTSILNFKFKETSNSIVGLDTPSVVSEENQALNINNETDL 320

Query: 484  YVESLQTHPYDKSKCHPSALAR--TKYAVSRWEIS-----------KACFAREALLISRQ 530
            +   +Q+  Y   K   S   +  T+  V+  +IS           K C  R    I   
Sbjct: 321  HTLWIQSPYYKHWKAITSKTVQECTRKDVNPDDISPIFSIPLKTQLKTCTVRAFERIIGD 380

Query: 531  RFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSAL-FFGLVHMMFNGFSELSL 589
            R   I +   V     V  ++F    +       G+    +L FF ++   F   +++  
Sbjct: 381  RNYLISQFVSVVVQSLVIGSLFYNIPL----TTIGSFSRGSLTFFSILFFTFLSLADMPA 436

Query: 590  MIARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFR 649
               R PV  K     FY  W  +L           I  VI+T+I+Y+      +A RFF 
Sbjct: 437  SFQRQPVVRKHVQLHFYYNWVETLATNFFDCCSKFILVVIFTIILYFLAHLQYNAARFFI 496

Query: 650  YMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWG 709
            ++  L V +   + LF + A IA  + +AN      LL I +   ++I    + PW+IW 
Sbjct: 497  FLLFLSVYNFCMVSLFALTALIAPTLSMANLLAGILLLAIAMYASYVIYMKDMHPWFIWI 556

Query: 710  YWLSPLTYGQRAITVNEF-------------------------TASRWMKQSALGNNTIG 744
             +L+P  +   AI  NE                           A  W + + LGN+ + 
Sbjct: 557  AYLNPAMFAMEAILSNELFNLKLDCHESIIPRGEYYDNISFSHKACAW-QGATLGNDYVR 615

Query: 745  YNILHAQSLPSEDYWYWVSVAVLVTYAIIFNIMVTLALAYLHPLQKPRTVIPQDDEPEK- 803
                    L    +  W +  +++ +   F     LA  Y+ PL     ++  ++  ++ 
Sbjct: 616  GRDYLKSGLKYTYHHVWRNFGIIIGFLCFFLFCSLLAAEYITPLFTRENLLRWNNYLKRY 675

Query: 804  ---SSSRDANYVFSTRSTKDESNTKGMILPFQPLTMTFHNVSYFVDMPQEIR-------- 852
                +S+  N   +  +       K  I  F   + +  +VS+  D    I+        
Sbjct: 676  CPFLNSQKKNNKSAITNNDGVCTPKTPIANFSTSSSSVPSVSHQYDTDYNIKHPDETVNN 735

Query: 853  --KQGIP-ETR---------------LQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVL 894
              K+ +  ET+                +L+++ SG  S G LTAL+G SGAGKTTL++VL
Sbjct: 736  HTKESVAMETQKHVISWKNINYTIGDKKLINDASGYISSG-LTALMGESGAGKTTLLNVL 794

Query: 895  AGRKTGGYIEGDIKISGYPKEQ-RTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKE 953
            + R   G + G++ I G P      F R  G+V+Q D+H   +T+ ESL  S  LR    
Sbjct: 795  SQRTESGVVTGELLIDGQPLTNIDAFRRSIGFVQQQDVHLELLTVRESLEISCVLR---- 850

Query: 954  ISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPS-IIFMD 1012
               D  R+++  V  L+ L S +         + LS  QRK L+I VELV  PS ++F+D
Sbjct: 851  --GDGDRDYLGVVSNLLRLPSEKLV-------ADLSPTQRKLLSIGVELVTKPSLLLFLD 901

Query: 1013 EPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGK 1072
            EPTSGLDA AA  +++ ++     G+ ++CTIHQPS  +   FD++ L+KRGG  +Y G 
Sbjct: 902  EPTSGLDAEAALTIVQFLKKLSMQGQAILCTIHQPSKSVISYFDNIYLLKRGGECVYFGS 961

Query: 1073 LGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEV----------------TTPSVEETI- 1115
            L       + + + +   R +    NPA +V++V                T+  ++E + 
Sbjct: 962  LPNACDYFVAHDRRLTFDREMD---NPADFVIDVVGSGSTNIPMDDAEKPTSSKIDEPVS 1018

Query: 1116 ------DADFAEIYNNSDQYRGVEASILEFEHPPAGSEPLKFDTIYS-QSLLSQFYRCLW 1168
                    ++AE++ +S +   V   +L  E     S      +++S  S + Q      
Sbjct: 1019 YHKQSDSINWAELWQSSPEKVRVADDLLLLEEEARKSGVDFTTSVWSPPSYMEQIKLITK 1078

Query: 1169 KQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQE-LYVVMGALYASCLFIG 1227
            +Q +   R   Y   +      + L  G  FW      +  Q+ +++    L  S   I 
Sbjct: 1079 RQYICTKRDMTYVFAKYALNAGAGLFIGFSFWRTKHNINGLQDAIFLCFMMLCVSSPLIN 1138

Query: 1228 VNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMIN 1287
                  +Q     +     RE  +  Y      +AQ ++E+P     + +F L  YF   
Sbjct: 1139 QVQDKALQS----KEVYIAREARSNTYHWTVLLIAQTIVELPLAISSSTLFFLCCYFCCG 1194

Query: 1288 FE---RTAGKFFL-YLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGF 1343
            FE   R AG F+L Y+LF      Y+  +G+  +  +P    AAV  +  YS      G 
Sbjct: 1195 FETSARVAGVFYLNYILFSM----YYLSFGLWLLYSAPDLQTAAVFVAFLYSFTASFCGV 1250

Query: 1344 LIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDVE 1379
            + P S  P +W + Y + P  + +   ++  L D E
Sbjct: 1251 MQPYSLFPRFWTFMYRVSPYTYFIETFVSLLLHDRE 1286



 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 121/571 (21%), Positives = 237/571 (41%), Gaps = 92/571 (16%)

Query: 177  ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGH---EADEFF 233
            ++++ SG I  G +T L+G  GAGK++LL  L+ + +S +  TG +  +G      D F 
Sbjct: 764  LINDASGYISSG-LTALMGESGAGKTTLLNVLSQRTESGVV-TGELLIDGQPLTNIDAF- 820

Query: 234  VKRTCAYISQTDNHTAELTVRETLDFAARCQG-AQEGFAAYTKDIGRLENERNIRPSPEI 292
             +R+  ++ Q D H   LTVRE+L+ +   +G     +     ++ RL +E+        
Sbjct: 821  -RRSIGFVQQQDVHLELLTVRESLEISCVLRGDGDRDYLGVVSNLLRLPSEK-------- 871

Query: 293  DAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTG-EMIVG 351
                                                  ++  +S  QRK ++ G E++  
Sbjct: 872  --------------------------------------LVADLSPTQRKLLSIGVELVTK 893

Query: 352  PRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSE 411
            P   LF+DE ++GLD+     IV+ +K  + +    +L  + QP+      FD++ LL  
Sbjct: 894  PSLLLFLDEPTSGLDAEAALTIVQFLKK-LSMQGQAILCTIHQPSKSVISYFDNIYLLKR 952

Query: 412  -GHVIYEGPRENVLEFFESIGFKLPPRKGI---ADFLQEVSSRKDQAQYWADPSKQYQFV 467
             G  +Y G   N  ++F +   +L   + +   ADF+ +V           D +++    
Sbjct: 953  GGECVYFGSLPNACDYFVAHDRRLTFDREMDNPADFVIDVVG-SGSTNIPMDDAEKPTSS 1011

Query: 468  PSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSAL--------ARTKYAVSRWEISKAC 519
               E     + S   ++ E  Q+ P +K +     L        +   +  S W  S   
Sbjct: 1012 KIDEPVSYHKQSDSINWAELWQSSP-EKVRVADDLLLLEEEARKSGVDFTTSVW--SPPS 1068

Query: 520  FAREALLISRQRFL-------YIF-KTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSA 571
            +  +  LI++++++       Y+F K    A  G      F RT+ H  +     +++  
Sbjct: 1069 YMEQIKLITKRQYICTKRDMTYVFAKYALNAGAGLFIGFSFWRTK-HNINGLQDAIFLCF 1127

Query: 572  LFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWS---LTNWVLRVPYSIIEAV 628
            +   +   + N   + +L    + +  + R N ++    W+   +   ++ +P +I  + 
Sbjct: 1128 MMLCVSSPLINQVQDKALQSKEVYIAREARSNTYH----WTVLLIAQTIVELPLAISSST 1183

Query: 629  IWTVIVYYTVGFAPSA--GRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAAL 686
            ++ +  Y+  GF  SA     F   +ILF M+ ++ GL+ + +  A D+  A  F +   
Sbjct: 1184 LFFLCCYFCCGFETSARVAGVFYLNYILFSMYYLSFGLWLLYS--APDLQTAAVFVAFLY 1241

Query: 687  LVIFLLGGFIIPKGMIKPWWIWGYWLSPLTY 717
                   G + P  +   +W + Y +SP TY
Sbjct: 1242 SFTASFCGVMQPYSLFPRFWTFMYRVSPYTY 1272


>YOH5_YEAST (Q08234) Probable ATP-dependent transporter
            YOL074C/YOL075C
          Length = 1294

 Score =  277 bits (709), Expect = 1e-73
 Identities = 291/1221 (23%), Positives = 530/1221 (42%), Gaps = 198/1221 (16%)

Query: 176  TILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITY----NGHEADE 231
            T+++  S  +  G +  ++G  G+GK++LL  LA K+   L   GSI Y     G E +E
Sbjct: 43   TLVNTFSMDLPSGSVMAVMGGSGSGKTTLLNVLASKISGGLTHNGSIRYVLEDTGSEPNE 102

Query: 232  FFVKRT--------------CAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDI 277
               KR                AY+ Q D  +  LT RETL FAA              D+
Sbjct: 103  TEPKRAHLDGQDHPIQKHVIMAYLPQQDVLSPRLTCRETLKFAA--------------DL 148

Query: 278  GRLENERNIRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSG 337
                +ER                   KK  V  + +++ LGL  C++T+VG +  RG+SG
Sbjct: 149  KLNSSERT------------------KKLMV--EQLIEELGLKDCADTLVGDNSHRGLSG 188

Query: 338  GQRKRVTTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAP 397
            G+++R++ G  ++     +F+DE +TGLD+ + F ++K +K        T +M++ QP  
Sbjct: 189  GEKRRLSIGTQMISNPSIMFLDEPTTGLDAYSAFLVIKTLKKLAKEDGRTFIMSIHQPRS 248

Query: 398  ETFELFDDLVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADF---LQEVSSRKDQA 454
            +   L D + +LS+G+V+Y    +N + +FESIG+ +P     AD+   L  V SR D+ 
Sbjct: 249  DILFLLDQVCILSKGNVVYCDKMDNTIPYFESIGYHVPQLVNPADYFIDLSSVDSRSDKE 308

Query: 455  QYWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWE 514
                               EA   SR  S ++    H +D  + H    A + Y  +  E
Sbjct: 309  -------------------EAATQSRLNSLID----HWHDYERTHLQLQAES-YISNATE 344

Query: 515  I------SKACFAREALLISRQRFLYIFKT--------CQVAFVGFVTCTIFLRTRMHPT 560
            I      ++  F ++  +++R+ F   F           +   +G V   I+ +    P 
Sbjct: 345  IQIQNMTTRLPFWKQVTVLTRRNFKLNFSDYVTLISTFAEPLIIGTVCGWIYYK----PD 400

Query: 561  DEAYGNL-------YVSALFFGLVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSL 613
              + G L       Y S +    ++++F+ +      IA   ++ ++R        A+ +
Sbjct: 401  KSSIGGLRTTTACLYASTILQCYLYLLFDTYRLCEQDIA---LYDRERAEGSVTPLAFIV 457

Query: 614  TNWV-LRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIA 672
               + L +       +I+  I Y+  G    A +FF    ++F+      GL  +  +++
Sbjct: 458  ARKISLFLSDDFAMTMIFVSITYFMFGLEADARKFFYQFAVVFLCQLSCSGLSMLSVAVS 517

Query: 673  RDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRW 732
            RD   A+  G+    V+ +  GF +   ++  +  W  +++   Y    +  + FT S  
Sbjct: 518  RDFSKASLVGNMTFTVLSMGCGFFVNAKVMPVYVRWIKYIAFTWYSFGTLMSSTFTNSYC 577

Query: 733  MKQSALGNNTIGYNILHAQSLPSEDYWYWVSVAVLVTYAIIFNIMVTLALAYLHPL---- 788
               +   +  +G  IL     P    W  V   VL+ +++ + ++  + L YLH +    
Sbjct: 578  TTDNL--DECLGNQILEVYGFPRN--WITVPAVVLLCWSVGYFVVGAIIL-YLHKIDITL 632

Query: 789  --------QKPRTVIPQDDEPEKSSSRDANYVFSTRSTKDESNTKGMILPFQPLTMTFHN 840
                    +K +   P   +PE     D  +       KD    KG  +    +T+   +
Sbjct: 633  QNEVKSKQKKIKKKSPTGMKPEIQLLDDVYH------QKDLEAEKGKNIH---ITIKLED 683

Query: 841  VSYFV--DMPQEIRKQGI--PETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAG 896
            +   V    P    K+G    ET+ ++L +V+ +F PG++ A++G SG+GK++L+++++G
Sbjct: 684  IDLRVIFSAPFSNWKEGNFHHETK-EILQSVNAIFKPGMINAIMGPSGSGKSSLLNLISG 742

Query: 897  RKTGGYI-----EGDIKISGYPKEQRTFARISGYVEQNDIHS-PQVTIEESLWFSASLRL 950
            R            G I  +     +  F  +  YV Q+D H    +T++E+L ++A+LRL
Sbjct: 743  RLKSSVFAKFDTSGSIMFNDIQVSELMFKNVCSYVSQDDDHLLAALTVKETLKYAAALRL 802

Query: 951  PKEISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIF 1010
               ++  ++ E  + +++ + L    N ++G     G+S  +++R+T+ V+L+ +P I+ 
Sbjct: 803  -HHLTEAERMERTDNLIRSLGLKHCENNIIGNEFVKGISGGEKRRVTMGVQLLNDPPILL 861

Query: 1011 MDEPTSGLDARAAAIVMRAVRNTV-DTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIY 1069
            +DEPTSGLD+  +A ++  +     + G+T++ TIHQP  ++F+ F ++LL+ + GR  +
Sbjct: 862  LDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPRSELFKRFGNVLLLAKSGRTAF 921

Query: 1070 GGKLGVQSQIMIDYFQGIRGIRPIPRGYN--PATWVLEVTTPSVEETIDADFAEIYNNSD 1127
             G        MI YF  +        GYN    T V +     +      +  EI + + 
Sbjct: 922  NG----SPDEMIAYFTEL--------GYNCPSFTNVADFFLDLISVNTQNEQNEISSRAR 969

Query: 1128 QYRGVEASILEFEHPPAGSEPLKFDTIYSQ-SLLSQFYRCLWK-QNLVYWRSPPYNAMRM 1185
              + + A     ++      P+     YSQ S  +++   + K  NLV   +   N  R 
Sbjct: 970  VEKILSAWKANMDNESLSPTPISEKQQYSQESFFTEYSEFVRKPANLVL--AYIVNVKRQ 1027

Query: 1186 YFTT-------------------ISALVFGTV---FWDIGSKRSSTQELYVVMGALYASC 1223
            + TT                   I AL F  V   +  I ++    QE      ALY   
Sbjct: 1028 FTTTRRSFDSLMARIAQIPGLGVIFALFFAPVKHNYTSISNRLGLAQE----STALY--- 1080

Query: 1224 LFIGVNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITY 1283
             F+G+       P    ER  FY E    +Y    + +A   +E+P  A+ ++++ + T 
Sbjct: 1081 -FVGMLGNLACYP---TERDYFYEEYNDNVYGIAPFFLAYMTLELPLSALASVLYAVFTV 1136

Query: 1284 FMINFERTAGKFFLYLLFMFL 1304
                  RTAG FF  +   F+
Sbjct: 1137 LACGLPRTAGNFFATVYCSFI 1157



 Score =  168 bits (426), Expect = 9e-41
 Identities = 157/548 (28%), Positives = 263/548 (47%), Gaps = 49/548 (8%)

Query: 858  ETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIE-GDIKI------- 909
            +T   L++  S     G + A++G SG+GKTTL++VLA + +GG    G I+        
Sbjct: 39   KTNTTLVNTFSMDLPSGSVMAVMGGSGSGKTTLLNVLASKISGGLTHNGSIRYVLEDTGS 98

Query: 910  ---SGYPKEQRTFAR--------ISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDK 958
                  PK      +        I  Y+ Q D+ SP++T  E+L F+A L+L     T  
Sbjct: 99   EPNETEPKRAHLDGQDHPIQKHVIMAYLPQQDVLSPRLTCRETLKFAADLKLNSSERT-- 156

Query: 959  KREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGL 1018
            K+  VEQ+++ + L    + LVG     GLS  +++RL+I  ++++NPSI+F+DEPT+GL
Sbjct: 157  KKLMVEQLIEELGLKDCADTLVGDNSHRGLSGGEKRRLSIGTQMISNPSIMFLDEPTTGL 216

Query: 1019 DARAAAIVMRAVRNTV-DTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQS 1077
            DA +A +V++ ++    + GRT + +IHQP  DI    D + ++ + G V+Y  K+    
Sbjct: 217  DAYSAFLVIKTLKKLAKEDGRTFIMSIHQPRSDILFLLDQVCILSK-GNVVYCDKM---- 271

Query: 1078 QIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSVEETIDADFAEIYN--NS--DQYRGVE 1133
               I YF+ I     +P+  NPA + ++++  SV+   D + A   +  NS  D +   E
Sbjct: 272  DNTIPYFESIG--YHVPQLVNPADYFIDLS--SVDSRSDKEEAATQSRLNSLIDHWHDYE 327

Query: 1134 ASILEFEHPPAGSEPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISA- 1192
             + L+ +   A S       I  Q++ ++     WKQ  V  R         Y T IS  
Sbjct: 328  RTHLQLQ---AESYISNATEIQIQNMTTRL--PFWKQVTVLTRRNFKLNFSDYVTLISTF 382

Query: 1193 ---LVFGTVFWDIGSK--RSSTQELYVVMGALYASCLF-IGVNNASTVQPIVSIERTVFY 1246
               L+ GTV   I  K  +SS   L      LYAS +    +        +   +  ++ 
Sbjct: 383  AEPLIIGTVCGWIYYKPDKSSIGGLRTTTACLYASTILQCYLYLLFDTYRLCEQDIALYD 442

Query: 1247 REKAAGMYSPIAYAVAQGL-IEIPYIAVQAMVFGLITYFMINFERTAGKFFLYLLFMFLT 1305
            RE+A G  +P+A+ VA+ + + +       M+F  ITYFM   E  A KFF     +FL 
Sbjct: 443  RERAEGSVTPLAFIVARKISLFLSDDFAMTMIFVSITYFMFGLEADARKFFYQFAVVFLC 502

Query: 1306 FTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQW 1365
                +   M++V +S     A+++ +  +++ ++  GF +    +P +  W  YI    W
Sbjct: 503  QLSCSGLSMLSVAVSRDFSKASLVGNMTFTVLSMGCGFFVNAKVMPVYVRWIKYIA-FTW 561

Query: 1366 TLRGVITS 1373
               G + S
Sbjct: 562  YSFGTLMS 569


>WHIT_DROME (P10090) White protein
          Length = 687

 Score =  214 bits (546), Expect = 1e-54
 Identities = 172/613 (28%), Positives = 287/613 (46%), Gaps = 39/613 (6%)

Query: 834  LTMTFHNVSYF--VDMPQE-------------IRKQGIPETRLQLLSNVSGVFSPGVLTA 878
            LT  +HN+  F  V+ P                 ++ IP  R  LL NV GV  PG L A
Sbjct: 68   LTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLA 127

Query: 879  LVGSSGAGKTTLMDVLAGRKTGGYI---EGDIKISGYPKEQRTFARISGYVEQNDIHSPQ 935
            ++GSSGAGKTTL++ LA R   G      G   ++G P + +       YV+Q+D+    
Sbjct: 128  VMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGS 187

Query: 936  VTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVELDSLRNALVGMPGS-SGLSTEQRK 994
            +T  E L F A +R+P+ ++  ++   V+QV++ + L   ++ ++G+PG   GLS  +RK
Sbjct: 188  LTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERK 247

Query: 995  RLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEA 1054
            RL  A E + +P ++  DEPTSGLD+  A  V++ ++     G+TV+ TIHQPS ++FE 
Sbjct: 248  RLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFEL 307

Query: 1055 FDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEV--TTPSVE 1112
            FD +LLM   GRV +   LG  S+  +D+F  +      P  YNPA + ++V    P  E
Sbjct: 308  FDKILLMAE-GRVAF---LGTPSE-AVDFFSYVGA--QCPTNYNPADFYVQVLAVVPGRE 360

Query: 1113 ETIDADFAEIYNN---SDQYRGVEASILEFEHPPAGSEPLKFDTIYSQSLLSQFYRCLWK 1169
                   A+I +N   S   R +E  +L  ++     E  +    Y  +   QF   LW+
Sbjct: 361  IESRDRIAKICDNFAISKVARDME-QLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWR 419

Query: 1170 QNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVN 1229
              L   + P    +R+  TT+ A++ G +F  +G + +    +  + GA++     +   
Sbjct: 420  SWLSVLKEPLLVKVRLIQTTMVAILIGLIF--LGQQLTQVGVMN-INGAIFLFLTNMTFQ 476

Query: 1230 NASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFE 1289
            N      + + E  VF RE  + +Y    Y + + + E+P      +VF  I Y MI   
Sbjct: 477  NVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLR 536

Query: 1290 RTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESH 1349
                 FF  L  + L     T +G +    S +  +A  +       + L  GF +    
Sbjct: 537  AGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGS 596

Query: 1350 IPGWWIWFYYICPVQWTLRGVITSQLGDVETKIIGPGFEGTV----KEYLSLNLGYDPKI 1405
            +P +  W  Y+   ++   G++ +Q  DVE   I      T      + +   L +    
Sbjct: 597  VPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAAD 656

Query: 1406 MGISTVGLSVIVL 1418
            + +  VGL+++++
Sbjct: 657  LPLDYVGLAILIV 669



 Score =  174 bits (440), Expect = 2e-42
 Identities = 158/668 (23%), Positives = 284/668 (41%), Gaps = 66/668 (9%)

Query: 126 NIEVRFSNLSVSADVQIGSRALPTLINYTRDALETICTNLGIYRPKRHSLTILDNVSGVI 185
           N+   + N+ +   V         L+N TR      C    I  P++H   +L NV GV 
Sbjct: 67  NLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLF---CNERHIPAPRKH---LLKNVCGVA 120

Query: 186 KPGRMTLLLGAPGAGKSSLLLALAGKLDSNLK--KTGSITYNGHEADEFFVKRTCAYISQ 243
            PG +  ++G+ GAGK++LL ALA +    ++   +G    NG   D   ++  CAY+ Q
Sbjct: 121 YPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQ 180

Query: 244 TDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFMKASSVGG 303
            D     LT RE L F A  +  +     Y + + R+                       
Sbjct: 181 DDLFIGSLTAREHLIFQAMVRMPRH--LTYRQRVARV----------------------- 215

Query: 304 KKHSVNTDYILKVLGLDICSETIVG-SDMLRGVSGGQRKRVTTGEMIVGPRKTLFMDEIS 362
                  D +++ L L  C  TI+G    ++G+SGG+RKR+      +     L  DE +
Sbjct: 216 -------DQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPT 268

Query: 363 TGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIYEGPREN 422
           +GLDS T   +V+ +K        TV++ + QP+ E FELFD ++L++EG V + G    
Sbjct: 269 SGLDSFTAHSVVQVLKKLSQ-KGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSE 327

Query: 423 VLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQYWADPSKQYQFVPSGEIAEAFRNSRFG 482
            ++FF  +G + P     ADF  +V +          P ++ +      IA+   N    
Sbjct: 328 AVDFFSYVGAQCPTNYNPADFYVQVLA--------VVPGREIE--SRDRIAKICDNFAIS 377

Query: 483 SYVESLQTHPYDKSKCHPSALARTKYAV-SRWEIS-KACFAREALLISRQRFLYIFKTCQ 540
                ++     K+   P       Y   + W +  +A   R  L + ++  L   +  Q
Sbjct: 378 KVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQ 437

Query: 541 VAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMF-NGFSELSLMIARLPVFYK 599
              V  +   IFL  ++  T     N+   A+F  L +M F N F+ +++  + LPVF +
Sbjct: 438 TTMVAILIGLIFLGQQL--TQVGVMNIN-GAIFLFLTNMTFQNVFATINVFTSELPVFMR 494

Query: 600 QRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQ 659
           +  +  Y    + L   +  +P  +   +++T I Y  +G       FF  + ++ ++  
Sbjct: 495 EARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVAN 554

Query: 660 MAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQ 719
           ++     +++  +    +A + G   ++   L GGF +  G +  +  W  +LS   Y  
Sbjct: 555 VSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYAN 614

Query: 720 RAITVNEFTASRWMKQSALGNNTI----GYNILHAQSLPSEDY-WYWVSVAVLVTYAIIF 774
             + +N++      + S   +NT     G  IL   +  + D    +V +A+L+   + F
Sbjct: 615 EGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILI---VSF 671

Query: 775 NIMVTLAL 782
            ++  LAL
Sbjct: 672 RVLAYLAL 679


>WHIT_LUCCU (Q05360) White protein
          Length = 677

 Score =  214 bits (544), Expect = 2e-54
 Identities = 155/534 (29%), Positives = 259/534 (48%), Gaps = 20/534 (3%)

Query: 856  IPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGDIKI---SGY 912
            IP+ R  L+ NV GV  PG L A++GSSGAGKTTL++ LA R   G       +   +G+
Sbjct: 94   IPKPRKHLIKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSARGVQISPSSVRMLNGH 153

Query: 913  PKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVEL 972
            P + +       YV+Q+D+    +T  E L F A++R+P+ ++  +K + V+QV++ + L
Sbjct: 154  PVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQATVRMPRTMTQKQKLQRVDQVIQDLSL 213

Query: 973  DSLRNALVGMPGS-SGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVR 1031
               +N ++G+PG   GLS  +RKRL  A E + +P ++  DEPTSGLD+  AA V++ ++
Sbjct: 214  IKCQNTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFMAASVVQVLK 273

Query: 1032 NTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIR 1091
                 G+TV+ TIHQPS ++FE FD +LLM   GRV +   LG   +  +D+F  I    
Sbjct: 274  KLSQRGKTVILTIHQPSSELFELFDKILLMAE-GRVAF---LGTPVE-AVDFFSFIGA-- 326

Query: 1092 PIPRGYNPATWVLEV--TTPSVEETIDADFAEIYNNSDQYRGVEASILEFEHPPAGSEPL 1149
              P  YNPA + ++V    P  E       ++I +N    +        F+   A ++ L
Sbjct: 327  QCPTNYNPADFYVQVLAVVPGREIESRDRISKICDNFAVGKVSREMEQNFQKIAAKTDGL 386

Query: 1150 KFD----TIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSK 1205
            + D     +Y  S  +QF   +W+  +   + P    +R+  TT+ A++ G +F +    
Sbjct: 387  QKDDETTILYKASWFTQFRAIMWRSWISTLKEPLLVKVRLIQTTMVAVLIGLIFLNQPMT 446

Query: 1206 RSSTQELYVVMGALYASCLFIGVNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGL 1265
            +        + GA++     +   N   V  + + E  VF RE  + +Y    Y + + L
Sbjct: 447  QVGVMN---INGAIFLFLTNMTFQNVFAVINVFTSELPVFMRETRSRLYRCDTYFLGKTL 503

Query: 1266 IEIPYIAVQAMVFGLITYFMINFERTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHL 1325
             E+P   V   +F  I Y MI        F   L  + L     T +G +    S +  +
Sbjct: 504  AELPLFLVVPFLFIAIAYPMIGLRPGITHFLSALALVTLVANVSTSFGYLISCASTSTSM 563

Query: 1326 AAVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDVE 1379
            A  +       + L  G  +    +P ++ W  Y    ++   G++ +Q  DV+
Sbjct: 564  ALSVGPPLTIPFLLFGGVFLNSGSVPVYFKWLSYFSWFRYANEGLLINQWADVQ 617



 Score =  154 bits (390), Expect = 1e-36
 Identities = 139/604 (23%), Positives = 253/604 (41%), Gaps = 62/604 (10%)

Query: 133 NLSVSADVQIGSRALPTLINYTRDALETICTNLGIYRPKRHSLTILDNVSGVIKPGRMTL 192
           NL V  +V         L+N  +      C    I +P++H   ++ NV GV  PG +  
Sbjct: 63  NLDVFGEVHQPGSNWKQLVNRVKGVF---CNERHIPKPRKH---LIKNVCGVAYPGELLA 116

Query: 193 LLGAPGAGKSSLLLALAGKLDSNLKKTGSIT--YNGHEADEFFVKRTCAYISQTDNHTAE 250
           ++G+ GAGK++LL ALA +    ++ + S     NGH  D   ++  CAY+ Q D     
Sbjct: 117 VMGSSGAGKTTLLNALAFRSARGVQISPSSVRMLNGHPVDAKEMQARCAYVQQDDLFIGS 176

Query: 251 LTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFMKASSVGGKKHSVNT 310
           LT RE L F A  +  +                                ++  K+     
Sbjct: 177 LTAREHLIFQATVRMPR--------------------------------TMTQKQKLQRV 204

Query: 311 DYILKVLGLDICSETIVG-SDMLRGVSGGQRKRVTTGEMIVGPRKTLFMDEISTGLDSST 369
           D +++ L L  C  TI+G    ++G+SGG+RKR+      +     L  DE ++GLDS  
Sbjct: 205 DQVIQDLSLIKCQNTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFM 264

Query: 370 TFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIYEGPRENVLEFFES 429
              +V+ +K        TV++ + QP+ E FELFD ++L++EG V + G     ++FF  
Sbjct: 265 AASVVQVLKKLSQ-RGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPVEAVDFFSF 323

Query: 430 IGFKLPPRKGIADFLQEVSSRKDQAQYWADPSKQYQFVPSGEIAEAFRNSRFGSYVESLQ 489
           IG + P     ADF  +V +          P ++ +      I++   N   G     ++
Sbjct: 324 IGAQCPTNYNPADFYVQVLA--------VVPGREIE--SRDRISKICDNFAVGKVSREME 373

Query: 490 THPYDKSKCHPSALARTK-----YAVSRWEISKACFAREALLISRQRFLYIFKTCQVAFV 544
            + + K       L +       Y  S +   +A   R  +   ++  L   +  Q   V
Sbjct: 374 QN-FQKIAAKTDGLQKDDETTILYKASWFTQFRAIMWRSWISTLKEPLLVKVRLIQTTMV 432

Query: 545 GFVTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMF-NGFSELSLMIARLPVFYKQRDN 603
             +   IFL   M  T     N+   A+F  L +M F N F+ +++  + LPVF ++  +
Sbjct: 433 AVLIGLIFLNQPM--TQVGVMNIN-GAIFLFLTNMTFQNVFAVINVFTSELPVFMRETRS 489

Query: 604 LFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMHQMAIG 663
             Y    + L   +  +P  ++   ++  I Y  +G  P    F   + ++ ++  ++  
Sbjct: 490 RLYRCDTYFLGKTLAELPLFLVVPFLFIAIAYPMIGLRPGITHFLSALALVTLVANVSTS 549

Query: 664 LFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYGQRAIT 723
              +++  +    +A + G    +   L GG  +  G +  ++ W  + S   Y    + 
Sbjct: 550 FGYLISCASTSTSMALSVGPPLTIPFLLFGGVFLNSGSVPVYFKWLSYFSWFRYANEGLL 609

Query: 724 VNEF 727
           +N++
Sbjct: 610 INQW 613


>WHIT_CERCA (Q17320) White protein
          Length = 679

 Score =  213 bits (543), Expect = 2e-54
 Identities = 164/592 (27%), Positives = 278/592 (46%), Gaps = 24/592 (4%)

Query: 856  IPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLAGRKTGGYIEGDIKI---SGY 912
            IP  R  LL N SGV  PG L A++GSSGAGKTTL++  A R + G       I   +G+
Sbjct: 96   IPAPRKHLLKNDSGVAYPGELLAVMGSSGAGKTTLLNASAFRSSKGVQISPSTIRMLNGH 155

Query: 913  PKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEISTDKKREFVEQVMKLVEL 972
            P + +       YV+Q+D+    +T  E L F A +R+P+ ++  +K + V+QV++ + L
Sbjct: 156  PVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHMTQKQKVQRVDQVIQDLSL 215

Query: 973  DSLRNALVGMPGS-SGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVR 1031
               +N L+G+PG   GLS  +RKRL  A E + +P ++  DEPTSGLD+  A  V++ ++
Sbjct: 216  GKCQNTLIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFMAHSVVQVLK 275

Query: 1032 NTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGVQSQIMIDYFQGIRGIR 1091
                 G+TV+ TIHQPS ++FE FD +LLM   GRV + G  G      +D+F  I    
Sbjct: 276  KLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPGE----AVDFFSYIGA-- 328

Query: 1092 PIPRGYNPATWVLEV--TTPSVEETIDADFAEIYNN---SDQYRGVEASILEFEHPPAGS 1146
              P  Y PA + ++V    P  E       A+I +N       R +E +  +        
Sbjct: 329  TCPTNYTPADFYVQVLAVVPGREVESRDRVAKICDNFAVGKVSREMEQNFQKLVKSNGFG 388

Query: 1147 EPLKFDTIYSQSLLSQFYRCLWKQNLVYWRSPPYNAMRMYFTTISALVFGTVFWDIGSKR 1206
            +  + +  Y  S   QF   LW+  L   + P    +R+  TT+ A++ G +F  +G + 
Sbjct: 389  KEDENEYTYKASWFMQFRAVLWRSWLSVLKEPLLVKVRLLQTTMVAVLIGLIF--LGQQL 446

Query: 1207 SSTQELYVVMGALYASCLFIGVNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLI 1266
            +    +  + GA++     +   N+     + + E  VF RE  + +Y    Y + + + 
Sbjct: 447  TQVGVMN-INGAIFLFLTNMTFQNSFATITVFTTELPVFMRETRSRLYRCDTYFLGKTIA 505

Query: 1267 EIPYIAVQAMVFGLITYFMINFERTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQHLA 1326
            E+P   V   +F  I Y +I        FF  L  + L     T +G +      +  +A
Sbjct: 506  ELPLFLVVPFLFTAIAYPLIGLRPGVDHFFTALALVTLVANVSTSFGYLISCACSSTSMA 565

Query: 1327 AVISSAFYSLWNLLSGFLIPESHIPGWWIWFYYICPVQWTLRGVITSQLGDVETKIIGPG 1386
              +       + L  GF +    +P ++ W  Y+   ++   G++ +Q  DV+   I   
Sbjct: 566  LSVGPPVIIPFLLFGGFFLNSGSVPVYFKWLSYLSWFRYANEGLLINQWADVKPGEITCT 625

Query: 1387 FEGTV----KEYLSLNLGYDPKIMGISTVGLSVIVLFGFIILFFCSFVVSVK 1434
               T      E +   L +    +    +GL+++++ GF I  + +  +  +
Sbjct: 626  LSNTTCPSSGEVILETLNFSASDLPFDFIGLALLIV-GFRISAYIALTMRAR 676



 Score =  164 bits (415), Expect = 2e-39
 Identities = 144/609 (23%), Positives = 255/609 (41%), Gaps = 59/609 (9%)

Query: 126 NIEVRFSNLSVSADVQIGSRALPTLINYTRDALETICTNLGIYRPKRHSLTILDNVSGVI 185
           N+   + NL V   V     +   L+N  +      C    I  P++H   +L N SGV 
Sbjct: 58  NLTYSWYNLDVFGAVHQPGSSWKQLVNRVKGVF---CNERHIPAPRKH---LLKNDSGVA 111

Query: 186 KPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSIT--YNGHEADEFFVKRTCAYISQ 243
            PG +  ++G+ GAGK++LL A A +    ++ + S     NGH  D   ++  CAY+ Q
Sbjct: 112 YPGELLAVMGSSGAGKTTLLNASAFRSSKGVQISPSTIRMLNGHPVDAKEMQARCAYVQQ 171

Query: 244 TDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFMKASSVGG 303
            D     LT RE L F A                        +R    +    K   V  
Sbjct: 172 DDLFIGSLTAREHLIFQAM-----------------------VRMPRHMTQKQKVQRV-- 206

Query: 304 KKHSVNTDYILKVLGLDICSETIVG-SDMLRGVSGGQRKRVTTGEMIVGPRKTLFMDEIS 362
                  D +++ L L  C  T++G    ++G+SGG+RKR+      +     L  DE +
Sbjct: 207 -------DQVIQDLSLGKCQNTLIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPT 259

Query: 363 TGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIYEGPREN 422
           +GLDS     +V+ +K        TV++ + QP+ E FELFD ++L++EG V + G    
Sbjct: 260 SGLDSFMAHSVVQVLKKLSQ-KGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPGE 318

Query: 423 VLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQYWADPSKQYQFVPSGEIAEAFRNSRFG 482
            ++FF  IG   P     ADF  +V +          P ++ +      +A+   N   G
Sbjct: 319 AVDFFSYIGATCPTNYTPADFYVQVLA--------VVPGREVE--SRDRVAKICDNFAVG 368

Query: 483 SYVESLQTHPYDKSKCHPSALA---RTKYAVSRWEISKACFAREALLISRQRFLYIFKTC 539
                ++ +     K +           Y  S +   +A   R  L + ++  L   +  
Sbjct: 369 KVSREMEQNFQKLVKSNGFGKEDENEYTYKASWFMQFRAVLWRSWLSVLKEPLLVKVRLL 428

Query: 540 QVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSALFFGLVHMMF-NGFSELSLMIARLPVFY 598
           Q   V  +   IFL  ++  T     N+   A+F  L +M F N F+ +++    LPVF 
Sbjct: 429 QTTMVAVLIGLIFLGQQL--TQVGVMNIN-GAIFLFLTNMTFQNSFATITVFTTELPVFM 485

Query: 599 KQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFAPSAGRFFRYMFILFVMH 658
           ++  +  Y    + L   +  +P  ++   ++T I Y  +G  P    FF  + ++ ++ 
Sbjct: 486 RETRSRLYRCDTYFLGKTIAELPLFLVVPFLFTAIAYPLIGLRPGVDHFFTALALVTLVA 545

Query: 659 QMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGMIKPWWIWGYWLSPLTYG 718
            ++     +++       +A + G   ++   L GGF +  G +  ++ W  +LS   Y 
Sbjct: 546 NVSTSFGYLISCACSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYFKWLSYLSWFRYA 605

Query: 719 QRAITVNEF 727
              + +N++
Sbjct: 606 NEGLLINQW 614


>ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1
            (White protein homolog) (ATP-binding cassette transporter
            8)
          Length = 666

 Score =  211 bits (538), Expect = 9e-54
 Identities = 177/618 (28%), Positives = 295/618 (47%), Gaps = 52/618 (8%)

Query: 781  ALAYLHPLQKPRTVIPQDDEPEKSSSRDANYVFSTRSTKDESNTKGMILPFQPL------ 834
            A +Y   + +P++V    DE   S+  +          K   N       F  L      
Sbjct: 16   ASSYSAAMTEPKSVCVSVDEVVSSNVDEVETDLLNGHLKKVDNNFTEAQRFSSLPRRAAV 75

Query: 835  TMTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVL 894
             + F ++SY V      +K+G       LL  +SG F+ G L A++G SGAGK+TLM++L
Sbjct: 76   NIEFKDLSYSVPEGPWWKKKGYKT----LLKGISGKFNSGELVAIMGPSGAGKSTLMNIL 131

Query: 895  AG-RKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKE 953
            AG R+TG  ++G + I+G P++ R F ++S Y+ Q+D+  P +T++E++  SA L+L ++
Sbjct: 132  AGYRETG--MKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 189

Query: 954  ISTDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDE 1013
               + +RE V++++  + L    N   G      LS  QRKRL IA+ELV NP ++F DE
Sbjct: 190  --DEGRREMVKEILTALGLLPCANTRTG-----SLSGGQRKRLAIALELVNNPPVMFFDE 242

Query: 1014 PTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKL 1073
            PTSGLD+ +   V+  ++     GR++VCTIHQPS  +FE FD L ++ + G+ +Y GK+
Sbjct: 243  PTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQ-GQCVYRGKV 301

Query: 1074 GVQSQIMIDYFQGIRGIRPIPRGYNPATWVLEVTTPSV------------EETIDADFAE 1121
                  ++ Y + + G+   P  +NPA +V+EV +               E   DAD+  
Sbjct: 302  ----SNLVPYLRDL-GLN-CPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDADY-- 353

Query: 1122 IYNNSDQYRGVEASILEF-EHPPAGSEPLKFDTI--YSQSLLSQFYRCLWKQNLVYWRSP 1178
                  +  G +  +  F  H PA  +    +    +S S L+QF     +  L   R  
Sbjct: 354  -----KRDLGGDTDVNPFLWHRPAEEDSASMEGCHSFSASCLTQFCILFKRTFLSIMRDS 408

Query: 1179 PYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYASCLFIGVNNASTVQPIV 1238
                +R+       L+ G ++  IG++    +++    G L+ S LF+            
Sbjct: 409  VLTHLRITSHIGIGLLIGLLYLGIGNE---AKKVLSNSGFLFFSMLFLMFAALMPTVLTF 465

Query: 1239 SIERTVFYREKAAGMYSPIAYAVAQGLIEIPYIAVQAMVFGLITYFMINFERTAGKFFLY 1298
             +E +VF RE     YS  AY +A+ + ++P+  +  + +  I Y+M +    A +F L+
Sbjct: 466  PLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLF 525

Query: 1299 LLFMFLTFTYFTFYGMMAVGLSPTQHLAAVISSAFYSLWNLLSGFLIPESHIPGWWIWFY 1358
                 +T       G++    S +  +A  +         L SGF +    IP +  W  
Sbjct: 526  AALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMS 585

Query: 1359 YICPVQWTLRGVITSQLG 1376
            YI  V++   GVI S  G
Sbjct: 586  YISYVRYGFEGVILSIYG 603



 Score =  153 bits (387), Expect = 3e-36
 Identities = 144/570 (25%), Positives = 244/570 (42%), Gaps = 56/570 (9%)

Query: 166 GIYRPKRHSLTILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYN 225
           G +  K+   T+L  +SG    G +  ++G  GAGKS+L+  LAG  ++ +K  G++  N
Sbjct: 89  GPWWKKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMK--GAVLIN 146

Query: 226 GHEADEFFVKRTCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERN 285
           G   D    ++   YI Q D     LTV+E +  +A  +  QE      KD GR E  + 
Sbjct: 147 GMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQE------KDEGRREMVKE 199

Query: 286 IRPSPEIDAFMKASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTT 345
           I                           L  LGL  C+ T  GS     +SGGQRKR+  
Sbjct: 200 I---------------------------LTALGLLPCANTRTGS-----LSGGQRKRLAI 227

Query: 346 GEMIVGPRKTLFMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDD 405
              +V     +F DE ++GLDS++ FQ+V  +K        +++  + QP+ + FELFD 
Sbjct: 228 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ-GGRSIVCTIHQPSAKLFELFDQ 286

Query: 406 LVLLSEGHVIYEGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKDQAQYWADPSKQYQ 465
           L +LS+G  +Y G   N++ +   +G   P     ADF+ EV+S     +Y    S+  +
Sbjct: 287 LYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVAS----GEYGDQNSRLVR 342

Query: 466 FVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRWEISKAC--FARE 523
            V  G     ++    G     +    + +     SA     ++ S   +++ C  F R 
Sbjct: 343 AVREGMCDADYKRDLGGD--TDVNPFLWHRPAEEDSASMEGCHSFSASCLTQFCILFKRT 400

Query: 524 ALLISRQRFLYIFKTCQVAFVGFVTCTIFLRTRMHPTDEAYGNLYVSA-LFFGLVHMMFN 582
            L I R   L   +      +G +   ++L       +EA   L  S  LFF ++ +MF 
Sbjct: 401 FLSIMRDSVLTHLRITSHIGIGLLIGLLYLGI----GNEAKKVLSNSGFLFFSMLFLMFA 456

Query: 583 GFSELSLMI-ARLPVFYKQRDNLFYPAWAWSLTNWVLRVPYSIIEAVIWTVIVYYTVGFA 641
                 L     + VF ++  N +Y   A+ L   +  VP+ I+  V +  IVY+     
Sbjct: 457 ALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQP 516

Query: 642 PSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGGFIIPKGM 701
             A RF  +  +  +   +A  L  ++ + +  + +A   G    + + L  GF +    
Sbjct: 517 SDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDT 576

Query: 702 IKPWWIWGYWLSPLTYGQRAITVNEFTASR 731
           I  +  W  ++S + YG   + ++ +   R
Sbjct: 577 IPAYLQWMSYISYVRYGFEGVILSIYGLDR 606


>ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2
            (Placenta-specific ATP-binding cassette transporter)
            (Breast cancer resistance protein)
          Length = 655

 Score =  208 bits (529), Expect = 1e-52
 Identities = 158/561 (28%), Positives = 280/561 (49%), Gaps = 64/561 (11%)

Query: 836  MTFHNVSYFVDMPQEIRKQGIPETRLQLLSNVSGVFSPGVLTALVGSSGAGKTTLMDVLA 895
            ++FHN+ Y V +         P  + ++LSN++G+  PG L A++G +G GK++L+DVLA
Sbjct: 37   LSFHNICYRVKLKSGFLPCRKPVEK-EILSNINGIMKPG-LNAILGPTGGGKSSLLDVLA 94

Query: 896  GRKTGGYIEGDIKISGYPKEQRTFARISGYVEQNDIHSPQVTIEESLWFSASLRLPKEIS 955
             RK    + GD+ I+G P+    F   SGYV Q+D+    +T+ E+L FSA+LRL   ++
Sbjct: 95   ARKDPSGLSGDVLINGAPRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMT 153

Query: 956  TDKKREFVEQVMKLVELDSLRNALVGMPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPT 1015
              +K E + +V++ + LD + ++ VG     G+S  +RKR +I +EL+ +PSI+F+DEPT
Sbjct: 154  NHEKNERINRVIEELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPT 213

Query: 1016 SGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDDLLLMKRGGRVIYGGKLGV 1075
            +GLD+  A  V+  ++     GRT++ +IHQP   IF+ FD L L+  G  + +G     
Sbjct: 214  TGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG----- 268

Query: 1076 QSQIMIDYFQGIRGIRPIPRGY------NPATWVL---------------------EVTT 1108
             +Q  + YF+          GY      NPA + L                     E+  
Sbjct: 269  PAQEALGYFES--------AGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIE 320

Query: 1109 PSVEE-TIDADFAEIYNNSDQYRGVEASILEFEHPPAGSEPLKFDTIYSQ-SLLSQF-YR 1165
            PS ++  +    AEIY NS  Y+  +A +    H  +G E  K  T++ + S  + F ++
Sbjct: 321  PSKQDKPLIEKLAEIYVNSSFYKETKAEL----HQLSGGEKKKKITVFKEISYTTSFCHQ 376

Query: 1166 CLWKQNLVYWR---SPPYNAMRMYFTTISALVFGTVFWDIGSKRSSTQELYVVMGALYAS 1222
              W     +     +P  +  ++  T +  LV G +++ + +  +  Q    V+  L  +
Sbjct: 377  LRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTN 436

Query: 1223 CLFIGVNNASTVQPIVSIERTVFYREKAAGMYSPIAYAVAQGLIE-IPYIAVQAMVFGLI 1281
              F   ++ S V+  V +E+ +F  E  +G Y   +Y + + L + +P   + +++F  I
Sbjct: 437  QCF---SSVSAVELFV-VEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCI 492

Query: 1282 TYFMINFERTAGKFFLYLLFMFLTFTYFTFYGMMAVGLSPTQ---HLAAVISSAFYSLWN 1338
             YFM+  +  A  FF+ ++F  +   Y      MA+ ++  Q    +A ++ +  +    
Sbjct: 493  VYFMLGLKPKADAFFV-MMFTLMMVAYSA--SSMALAIAAGQSVVSVATLLMTICFVFMM 549

Query: 1339 LLSGFLIPESHIPGWWIWFYY 1359
            + SG L+  + I  W  W  Y
Sbjct: 550  IFSGLLVNLTTIASWLSWLQY 570



 Score =  179 bits (454), Expect = 5e-44
 Identities = 163/638 (25%), Positives = 279/638 (43%), Gaps = 78/638 (12%)

Query: 177 ILDNVSGVIKPGRMTLLLGAPGAGKSSLLLALAGKLDSNLKKTGSITYNGHEADEFFVKR 236
           IL N++G++KPG +  +LG  G GKSSLL  LA + D +   +G +  NG      F K 
Sbjct: 63  ILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPS-GLSGDVLINGAPRPANF-KC 119

Query: 237 TCAYISQTDNHTAELTVRETLDFAARCQGAQEGFAAYTKDIGRLENERNIRPSPEIDAFM 296
              Y+ Q D     LTVRE L F+A                                A  
Sbjct: 120 NSGYVVQDDVVMGTLTVRENLQFSA--------------------------------ALR 147

Query: 297 KASSVGGKKHSVNTDYILKVLGLDICSETIVGSDMLRGVSGGQRKRVTTGEMIVGPRKTL 356
            A+++   + +   + +++ LGLD  +++ VG+  +RGVSGG+RKR + G  ++     L
Sbjct: 148 LATTMTNHEKNERINRVIEELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSIL 207

Query: 357 FMDEISTGLDSSTTFQIVKCIKNFVHLMDATVLMALLQPAPETFELFDDLVLLSEGHVIY 416
           F+DE +TGLDSST   ++  +K  +     T++ ++ QP    F+LFD L LL+ G +++
Sbjct: 208 FLDEPTTGLDSSTANAVLLLLKR-MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMF 266

Query: 417 EGPRENVLEFFESIGFKLPPRKGIADFLQEVSSRKD-----------QAQYWADPSKQYQ 465
            GP +  L +FES G+        ADF  ++ +              +A    +PSKQ +
Sbjct: 267 HGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDK 326

Query: 466 FVPSGEIAEAFRNSRFGSYVESLQTHPYDKSKCHPSALARTKYAVSRW-EIS-KACFARE 523
            +   ++AE + NS F  Y E+       K++ H  +    K  ++ + EIS    F  +
Sbjct: 327 PLIE-KLAEIYVNSSF--YKET-------KAELHQLSGGEKKKKITVFKEISYTTSFCHQ 376

Query: 524 ALLISRQRFLYIFKTCQVAF--------VGFVTCTIFLRTRMHPTDEAYGNLYVSALFFG 575
              +S++ F  +    Q +         +G V   I+   +    D          LFF 
Sbjct: 377 LRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLK---NDSTGIQNRAGVLFFL 433

Query: 576 LVHMMFNGFSELSLMIARLPVFYKQRDNLFYPAWAWSLTNWVL-RVPYSIIEAVIWTVIV 634
             +  F+  S + L +    +F  +  + +Y   ++ L   +   +P  ++ ++I+T IV
Sbjct: 434 TTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIV 493

Query: 635 YYTVGFAPSAGRFFRYMFILFVMHQMAIGLFRMMASIARDMVLANTFGSAALLVIFLLGG 694
           Y+ +G  P A  FF  MF L ++   A  +   +A+    + +A    +   + + +  G
Sbjct: 494 YFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSG 553

Query: 695 FIIPKGMIKPWWIWGYWLSPLTYGQRAITVNEFTASRWMK-QSALGNNTIGY------NI 747
            ++    I  W  W  + S   YG  A+  NEF    +    +A GNN   Y        
Sbjct: 554 LLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEY 613

Query: 748 LHAQSLPSEDYWYWVSVAVLVTYAIIFNIMVTLALAYL 785
           L  Q +    +  W +   L    +IF  +  L L +L
Sbjct: 614 LVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFL 651


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.323    0.138    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 165,904,108
Number of Sequences: 164201
Number of extensions: 7191045
Number of successful extensions: 25575
Number of sequences better than 10.0: 992
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 21422
Number of HSP's gapped (non-prelim): 3353
length of query: 1441
length of database: 59,974,054
effective HSP length: 123
effective length of query: 1318
effective length of database: 39,777,331
effective search space: 52426522258
effective search space used: 52426522258
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 72 (32.3 bits)