BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0336.15
(501 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ALN_STRCO (Q9RKU5) Probable allantoinase (EC 3.5.2.5) 320 7e-87
ALN_RANCA (P40757) Allantoinase, mitochondrial precursor (EC 3.5... 312 1e-84
ALN_YEAST (P32375) Allantoinase (EC 3.5.2.5) 301 3e-81
ALN_DEIRA (Q9RV76) Probable allantoinase (EC 3.5.2.5) 261 3e-69
ALN_ECOLI (P77671) Allantoinase (EC 3.5.2.5) 246 1e-64
ALN_BACSU (O32137) Allantoinase (EC 3.5.2.5) 226 1e-58
HYDL_ARTAU (P81006) Non-ATP-dependent L-selective hydantoinase (... 156 1e-37
PYRC_THEAQ (P96081) Dihydroorotase (EC 3.5.2.3) (DHOase) 141 3e-33
PYRC_LACPL (P77884) Dihydroorotase (EC 3.5.2.3) (DHOase) 140 1e-32
PYRC_THETN (Q8R9R6) Dihydroorotase (EC 3.5.2.3) (DHOase) 139 1e-32
PYRC_AQUAE (O66990) Dihydroorotase (EC 3.5.2.3) (DHOase) 138 4e-32
PYRC_STAEP (Q8CPJ6) Dihydroorotase (EC 3.5.2.3) (DHOase) 133 1e-30
PYRC_METTH (O27199) Dihydroorotase (EC 3.5.2.3) (DHOase) 131 5e-30
PYRC_HALN1 (Q9HMH9) Dihydroorotase (EC 3.5.2.3) (DHOase) 130 8e-30
HYDA_BACST (Q45515) D-hydantoinase (EC 3.5.2.2) (Dihydropyrimidi... 130 8e-30
HYDA_AGRTU (Q44184) D-hydantoinase (EC 3.5.2.2) (Dihydropyrimidi... 126 1e-28
PYRC_METAC (Q8TSA6) Dihydroorotase (EC 3.5.2.3) (DHOase) 125 3e-28
PYRC_STAAW (P65907) Dihydroorotase (EC 3.5.2.3) (DHOase) 124 4e-28
PYRC_STAAN (P65906) Dihydroorotase (EC 3.5.2.3) (DHOase) 124 4e-28
PYRC_STAAM (P65905) Dihydroorotase (EC 3.5.2.3) (DHOase) 124 4e-28
>ALN_STRCO (Q9RKU5) Probable allantoinase (EC 3.5.2.5)
Length = 445
Score = 320 bits (819), Expect = 7e-87
Identities = 175/405 (43%), Positives = 250/405 (61%), Gaps = 23/405 (5%)
Query: 85 DYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQET 144
D G+ V++PGL+D HVH+++PGRTEWEGF T TRAAAAGG+TT+VDMPLN+ P T + +
Sbjct: 49 DVGDHVVLPGLVDTHVHVNDPGRTEWEGFWTATRAAAAGGITTLVDMPLNSIPPTTTVDN 108
Query: 145 LQLKLEAAENELHVDVGFWGGLVPENALNTSILEGLLSAGVLGLKSFMCPSGINDFPMTT 204
L+ K E A ++ H+DVGFWGG +P+N + L L AGV G K+F+ PSG+++FP
Sbjct: 109 LRTKREVAADKAHIDVGFWGGALPDNVKD---LRPLHEAGVFGFKAFLSPSGVDEFPHLD 165
Query: 205 IDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIK 264
+ + L+ +A + L+VHAE ++L Y+ +L +RP E+ AI
Sbjct: 166 QEQLARSLAEIAAFDGLLIVHAE----DPHHLAAAPQQGGPKYTHFLASRPRDAEDTAIA 221
Query: 265 ELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEE 324
L+ K A VH++HLS SS +L LI EA+ G ++VETC HYL ++EE
Sbjct: 222 TLLAQAKRF-------NARVHVLHLS-SSDALPLIAEARADGVRVTVETCPHYLTLTAEE 273
Query: 325 IPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGG 384
+PDG + FKC PPIR+A N++ LW+A+ +G ID + +DHSP+ + LK DF AWGG
Sbjct: 274 VPDGASEFKCCPPIREAANQDLLWQALADGTIDCVVTDHSPSTAD---LKTDDFATAWGG 330
Query: 385 ISSLQFDLPVTWSYGKKHGLTLEQLSLLWSQKPATLAGI-ASKGAIVVGNHADIVVWHPE 443
I+ LQ LP W+ + GL LE + S++ A L G+ A KGAI G+ AD V P+
Sbjct: 331 IAGLQLSLPAMWTAARGRGLGLEDVVRWMSERTAALVGLDARKGAIAPGHDADFAVLAPD 390
Query: 444 LEFELNDDYPVFLKHPN-LSAYMGRRLSGKVLDTFVRGNLVFKDG 487
F ++ P L+H N ++AY G+ L G V T++RG + DG
Sbjct: 391 ETFTVD---PAALQHRNRVTAYAGKTLYGVVKSTWLRGERIVADG 432
>ALN_RANCA (P40757) Allantoinase, mitochondrial precursor (EC
3.5.2.5)
Length = 484
Score = 312 bits (799), Expect = 1e-84
Identities = 172/387 (44%), Positives = 245/387 (62%), Gaps = 18/387 (4%)
Query: 37 RVGIDFEKRKADPYTLNHSEDLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLI 96
++ + KR T++ S D+ I++GKI S+ +GK S ++ +D G+ V+M G+I
Sbjct: 17 KISVIRSKRVIQANTIS-SCDIIISDGKISSVL-AWGKHVTSGAKL-LDVGDLVVMAGII 73
Query: 97 DVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENEL 156
D HVH++EPGRT+WEG+ T T AAAAGG+T +VDMPLN+ P T S KL+AA+ +
Sbjct: 74 DPHVHVNEPGRTDWEGYRTATLAAAAGGITAIVDMPLNSLPPTTSVTNFHTKLQAAKRQC 133
Query: 157 HVDVGFWGGLVPENALNTSILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLA 216
+VDV FWGG++P+N + L +L AGV G K F+ SG+ +FP ++ + +S L
Sbjct: 134 YVDVAFWGGVIPDNQVE---LIPMLQAGVAGFKCFLINSGVPEFPHVSVTDLHTAMSELQ 190
Query: 217 KYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHG 276
LL HAE++ +K E+ D +Y T+L++RP E AA++ + D+ +
Sbjct: 191 GTNSVLLFHAELEI-AKPAPEI---GDSTLYQTFLDSRPDDMEIAAVQLVADLCQQY--- 243
Query: 277 GPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSP 336
HIVHLS S+ SL +I++AK G ++VET HYL+ SSE IP G T FKC P
Sbjct: 244 ----KVRCHIVHLS-SAQSLTIIRKAKEAGAPLTVETTHHYLSLSSEHIPPGATYFKCCP 298
Query: 337 PIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTW 396
P+R NKE LW A+L+GHID++ SDHSP P+LKLLKEGD++KAWGGISSLQF LP+ W
Sbjct: 299 PVRGHRNKEALWNALLQGHIDMVVSDHSPCTPDLKLLKEGDYMKAWGGISSLQFGLPLFW 358
Query: 397 SYGKKHGLTLEQLSLLWSQKPATLAGI 423
+ + G +L +S L S A L G+
Sbjct: 359 TSARTRGFSLTDVSQLLSSNTAKLCGL 385
>ALN_YEAST (P32375) Allantoinase (EC 3.5.2.5)
Length = 460
Score = 301 bits (770), Expect = 3e-81
Identities = 177/438 (40%), Positives = 266/438 (60%), Gaps = 24/438 (5%)
Query: 50 YTLNHSEDLEINEGKIVSITEGYGKQGNSKQEV--VIDYGEAVIMPGLIDVHVHLDEPGR 107
Y+ L++ EG +V K +K E+ + + I+PGL+D HVHL+EPGR
Sbjct: 24 YSTESGTILDVLEGSVVM-----EKTEITKYEIHTLENVSPCTILPGLVDSHVHLNEPGR 78
Query: 108 TEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLV 167
T WEGF TGT+AA +GGVTTVVDMPLN P T + E ++KLEAAE ++ DVGFWGGLV
Sbjct: 79 TSWEGFETGTQAAISGGVTTVVDMPLNAIPPTTNVENFRIKLEAAEGQMWCDVGFWGGLV 138
Query: 168 PENALNTSILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAE 227
P N + L L+ AGV G K F+ SG+ +FP ++I+E L VLA+ ++ HAE
Sbjct: 139 PHNLPD---LIPLVKAGVRGFKGFLLDSGVEEFPPIGKEYIEEALKVLAEEDTMMMFHAE 195
Query: 228 IQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIV 287
+ + ++ + + R YS++L++RP S+E AI +++ + GP+ VHIV
Sbjct: 196 LPKAHED--QQQPEQSHREYSSFLSSRPDSFEIDAINLILECLR--ARNGPV--PPVHIV 249
Query: 288 HLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKL 347
HL+ S ++ LI++A+ G ++ ETC HYL ++E+IPDG T FKC PPIR N++ L
Sbjct: 250 HLA-SMKAIPLIRKARASGLPVTTETCFHYLCIAAEQIPDGATYFKCCPPIRSESNRQGL 308
Query: 348 WEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHGLTLE 407
W+A+ EG I + SDHSP PELK L++GDF +WGGI+S+ LP+ ++ G +L
Sbjct: 309 WDALREGVIGSVVSDHSPCTPELKNLQKGDFFDSWGGIASVGLGLPLMFT----QGCSLV 364
Query: 408 QLSLLWSQKPATLAGIA-SKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMG 466
+ + + G++ KG I G AD+VV+ + ++++ V+ K+ L+AY G
Sbjct: 365 DIVTWCCKNTSHQVGLSHQKGTIAPGYDADLVVFDTASKHKISNS-SVYFKN-KLTAYNG 422
Query: 467 RRLSGKVLDTFVRGNLVF 484
+ G VL T +RG +V+
Sbjct: 423 MTVKGTVLKTILRGQVVY 440
>ALN_DEIRA (Q9RV76) Probable allantoinase (EC 3.5.2.5)
Length = 448
Score = 261 bits (667), Expect = 3e-69
Identities = 155/433 (35%), Positives = 233/433 (53%), Gaps = 22/433 (5%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
DL I G+I +T+ +D + PG++D HVHL+EPGRT WEGF TG
Sbjct: 22 DLGIVGGQIAELTDEIATPAAQ----TLDVSGLHVFPGVLDDHVHLNEPGRTHWEGFETG 77
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
T+A AAGG T+ +DMPLN+ P +++E + K E + +D G WGGL P LN
Sbjct: 78 TQALAAGGATSFLDMPLNSSPPVLTRERFEDKARLGEEKSLIDFGLWGGLTP---LNLDQ 134
Query: 177 LEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNL 236
L+ L GV+GLK+FM SG+++FP + EG+ ++ + HAE + ++
Sbjct: 135 LDDLAECGVIGLKAFMSHSGLDEFPAADDLTLYEGMRTAKRHGLVVATHAESNEFTRRLT 194
Query: 237 ELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSL 296
E YL +RP E A++ + +DT GA +H+VH+S S ++
Sbjct: 195 ETARAQGKSGVRDYLESRPVVTELEAVQRALLFAQDT-------GAALHLVHVS-SGAAV 246
Query: 297 DLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHI 356
L E K +G +++ETC HYL F+ E++ KC+PP+RD +E+LW +L GHI
Sbjct: 247 ALAYEGKQKGIDVTIETCPHYLHFTGEDVERVGAALKCAPPLRDPAVQEELWRELLAGHI 306
Query: 357 DLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYG-KKHGLTLEQLSLLWSQ 415
D + SDHSP P++K + DF WGGIS Q L V G + GL LE ++ L +
Sbjct: 307 DTVGSDHSPAPPDMKTSE--DFFSLWGGISGAQSTLNVMLEDGYAQRGLPLEIIAALLAL 364
Query: 416 KPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLD 475
PA G+ KG + VG AD + +F L+ Y + ++P Y G+ G+V
Sbjct: 365 NPAQRFGLPQKGRLAVGADADFALVALGEKFTLDTLYDRWQQNP----YRGQSFQGRVHA 420
Query: 476 TFVRGNLVFKDGK 488
T++RG V+++G+
Sbjct: 421 TYLRGQPVYQNGE 433
>ALN_ECOLI (P77671) Allantoinase (EC 3.5.2.5)
Length = 453
Score = 246 bits (627), Expect = 1e-64
Identities = 149/449 (33%), Positives = 240/449 (53%), Gaps = 40/449 (8%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
D+ + GKI +I + G ++K+ V+D V+ PG++D H H+ EPGR+ WEG+ TG
Sbjct: 22 DIAVKGGKIAAIGQDLG---DAKE--VMDASGLVVSPGMVDAHTHISEPGRSHWEGYETG 76
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
TRAAA GG+TT+++MPLN P TV + +++LK +AA+ +L +D GGLV + N
Sbjct: 77 TRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLV---SYNIDR 133
Query: 177 LEGLLSAGVLGLKSFMCPSG----INDFPMTTIDHIKEGLSVLAKYRRPLLVHA------ 226
L L GV+G K F+ G NDF +G L + +P+LVH
Sbjct: 134 LHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALIC 193
Query: 227 -EIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVH 285
E+ +++K + +D Y+ +RP E AI+ ++ + K + G +H
Sbjct: 194 DELGEEAKREGRVTAHD-------YVASRPVFTEVEAIRRVLYLAK-------VAGCRLH 239
Query: 286 IVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKE 345
+ H+S S ++ + A+ G ++ E+C HY +++ + T KCSPPIRD N++
Sbjct: 240 VCHVS-SPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQK 298
Query: 346 KLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYG-KKHGL 404
+WE + G ID L SDHSP PE +K G+ +KAWGGI+ LQ + V + +K G+
Sbjct: 299 GMWEKLFNGEIDCLVSDHSPCPPE---MKAGNIMKAWGGIAGLQSCMDVMFDEAVQKRGM 355
Query: 405 TLEQLSLLWSQKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAY 464
+L L + A + G+ KG I G AD V P + L +D + +H +S Y
Sbjct: 356 SLPMFGKLMATNAADIFGLQQKGRIAPGKDADFVFIQPNSSYVLTND-DLEYRH-KVSPY 413
Query: 465 MGRRLSGKVLDTFVRGNLVFKDGKHAPAA 493
+GR + ++ T +RG++++ + P A
Sbjct: 414 VGRTIGARITKTILRGDVIYDIEQGFPVA 442
>ALN_BACSU (O32137) Allantoinase (EC 3.5.2.5)
Length = 446
Score = 226 bits (575), Expect = 1e-58
Identities = 148/435 (34%), Positives = 219/435 (50%), Gaps = 26/435 (5%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
D+ + G I I G +I + PG+ID HVH +EPGR +WEGF TG
Sbjct: 22 DIVVQNGVIAEIGSDIEASGTE----IIQADGKYVFPGVIDCHVHFNEPGREDWEGFETG 77
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
++ AAGG TT DMPLN P+TV+ E L K E + VD WGGLVP + +
Sbjct: 78 SQMMAAGGCTTYFDMPLNCIPSTVTAEHLLAKAELGRQKSAVDFALWGGLVPGHIED--- 134
Query: 177 LEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAE---IQQDSK 233
+ + AG +G K+F+ SG ++F + +G++ +A + L +HAE I +
Sbjct: 135 IRPMAEAGAIGFKAFLSKSGTDEFRSVDERTLLKGMAEIAAAGKILALHAESDAITSYLQ 194
Query: 234 NNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSS 293
L KG D Y+ +RP E A+ + K T G VH VH+S ++
Sbjct: 195 MVLANKGKVDADAYAA---SRPEEAEVEAVYRTIQYAKVT-------GCPVHFVHIS-TA 243
Query: 294 VSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLE 353
++ LI+EAK G +SVETC HY+ FS +++ + KC+PP+R +KE L E ++
Sbjct: 244 KAVRLIREAKQEGLDVSVETCPHYVLFSHDDLRQRGSVAKCAPPLRSRQSKETLIETLIA 303
Query: 354 GHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHGLTLEQLSLLW 413
G ID+++SDHSP P LK +E + +WGGIS QF L +H + E ++
Sbjct: 304 GDIDMVSSDHSPCRPSLK--REDNMFLSWGGISGGQFTLLGMLELALEHQIPFETIAEWT 361
Query: 414 SQKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKV 473
+ PA G+ KG + G AD V+ E + +F KH S Y G +
Sbjct: 362 AAAPAKRFGLQKKGRLEAGCDADFVLVSMEPYTVTRES--MFAKHKK-SIYEGHTFPCSI 418
Query: 474 LDTFVRGNLVFKDGK 488
T+ +G V+ DG+
Sbjct: 419 SATYSKGRCVYNDGE 433
>HYDL_ARTAU (P81006) Non-ATP-dependent L-selective hydantoinase (EC
3.5.2.-)
Length = 458
Score = 156 bits (395), Expect = 1e-37
Identities = 127/438 (28%), Positives = 209/438 (46%), Gaps = 26/438 (5%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHL-DEPGRTEWEGFVT 115
D+ + +GK+ +I+ S+ ID G +MPG++D HVH+ D + + F
Sbjct: 21 DILVKDGKVAAISADTSDVEASR---TIDAGGKFVMPGVVDEHVHIIDMDLKNRYGRFEL 77
Query: 116 GTRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTS 175
+ +AA GG+TT+++MP+ PTT L+ K +A + L VD +GG VP N
Sbjct: 78 DSESAAVGGITTIIEMPITFPPTTTLDAFLEKKKQAGQR-LKVDFALYGGGVPGNLPE-- 134
Query: 176 ILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAE---IQQDS 232
+ + AG +G KS M S F + + E +A ++VHAE I Q
Sbjct: 135 -IRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEIAACGSVIVVHAENETIIQAL 193
Query: 233 KNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDS 292
+ ++ G D Y ++P E AI+ + + K+ G + ++H+S+
Sbjct: 194 QKQIKAAGGKDMAAYEA---SQPVFQENEAIQRALLLQKEA-------GCRLIVLHVSNP 243
Query: 293 SVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVL 352
++LI +A+ G + E+ YL ++++ K +PP+R A +LWE +
Sbjct: 244 D-GVELIHQAQSEGQDVHCESGPQYLNITTDDAERIGPYMKVAPPVRSAEMNIRLWEQLE 302
Query: 353 EGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSL 411
G ID L SDH E K D KA G L+ LP+ + G G L+LE+L
Sbjct: 303 NGLIDTLGSDHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMMLTNGVNKGRLSLERLVE 362
Query: 412 LWSQKPATLAGI-ASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLS 470
+ +KPA L GI KG + VG+ AD+++ +L+ + D F S + G ++
Sbjct: 363 VMCEKPAKLFGIYPQKGTLQVGSDADLLIL--DLDIDTKVDASQFRSLHKYSPFDGMPVT 420
Query: 471 GKVLDTFVRGNLVFKDGK 488
G + T VRG +V + G+
Sbjct: 421 GAPVLTMVRGTVVAEKGE 438
>PYRC_THEAQ (P96081) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 426
Score = 141 bits (356), Expect = 3e-33
Identities = 132/432 (30%), Positives = 194/432 (44%), Gaps = 35/432 (8%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
D+ I EG+I+S+ G KQ V+D + PG +D+H HL EPG E +G
Sbjct: 20 DVLIGEGRILSLEGGEAKQ-------VVDGTGCFLAPGFLDLHAHLREPGEEVKEDLFSG 72
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
AA GG T +V MP N P + LK +A L L P AL T
Sbjct: 73 LLAAVRGGYTDLVSMPNTNPPVDTPEAVRALKEKAKALGL-------ARLHPAAAL-TEK 124
Query: 177 LEG--LLSAGVLGLKSFMCPSGINDFPMTTIDH--IKEGLSVLAKYRRPLLVHAEIQQDS 232
EG L AG+L + + D T D + GL + A P+ VHAE
Sbjct: 125 QEGKTLTPAGLLQEAGAVL---LTDDGRTNEDAGVLAAGLLMAAPLGLPVAVHAEDAGLR 181
Query: 233 KNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDS 292
+N + ND P L PP E A I ++V + + P +H+ HLS
Sbjct: 182 RNGVM---NDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPAT-PRLHVQHLSTK 237
Query: 293 SVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVL 352
L+L++EAK G ++ E H+L + E + D FK +PP+R ++E L E +L
Sbjct: 238 R-GLELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLL 296
Query: 353 EGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWS-YGKKHGLTLEQLSL 411
+G +D + +DH+ P + KE D L+A GI SL+ P+ ++ K G L +L
Sbjct: 297 DGTLDAIATDHA---PHTQAEKEMDLLRAPFGIPSLEVAFPLLYTELHLKRGFPLRRLVE 353
Query: 412 LWSQKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSG 471
L++ P + G+ + G A +V+ P+ E D F S + G RL G
Sbjct: 354 LFTDGPRRVLGLPPL-HLEEGTEASLVLLDPK---ERPVDPQGFASKARFSPWTGWRLGG 409
Query: 472 KVLDTFVRGNLV 483
+ T V G +V
Sbjct: 410 WPVLTLVEGRIV 421
>PYRC_LACPL (P77884) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 430
Score = 140 bits (352), Expect = 1e-32
Identities = 123/438 (28%), Positives = 198/438 (45%), Gaps = 29/438 (6%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
D+ I EG+I +I Q V+ + + PG +DVHVHL +PG+T E TG
Sbjct: 20 DILIAEGRIKAIGHQLHDQFGPADHVICA-DQHFVSPGFVDVHVHLRDPGQTAKETIATG 78
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
T AAA GG TTV MP N P + E + + + E HV V + + +
Sbjct: 79 TLAAAHGGFTTVGAMP-NVDPVPDTPERVATMVARNQQEAHVHVAQYASITTGRTSEQLV 137
Query: 177 -LEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNN 235
G+ +AG + + SG+ T + + AK PL H E +
Sbjct: 138 DFAGIKAAGAFAVSN--DGSGVQ-----TAGTMFAAMQGAAKVGLPLAAHVEDDSLYHHG 190
Query: 236 LELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVS 295
+ G R+ +N + E V +D + G H H+ H+S ++ S
Sbjct: 191 VMNAGPVADRLGLPGINN---------VSEAAQVARDVML-AEASGVHYHVCHVS-TAES 239
Query: 296 LDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGH 355
L +I+ AK G +++ E H+L E+I + K +PP+R A ++ L +L+G
Sbjct: 240 LRVIRNAKAAGINVTCEVSPHHLLLCDEDITMDNPMLKMNPPLRSAKDRAALVAGLLDGT 299
Query: 356 IDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTW-SYGKKHGLTLEQLSLLWS 414
ID++ +DH+ P K+G A GI+ ++ + + K LTL +L L S
Sbjct: 300 IDMIATDHA---PHTDAEKQGSMKTAAFGITGIETAFATLYTALVKTRLLTLGRLIELMS 356
Query: 415 QKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVL 474
+PA L G+ + G +VVG AD+ + + ++E+ + L + S ++G + G VL
Sbjct: 357 TRPAELFGLNTAGRLVVGAPADLTIIDLDHQYEI--EAATMLSKGHNSPFIGWPVYGNVL 414
Query: 475 DTFVRGNLVFKDGKHAPA 492
T V G L + GK A
Sbjct: 415 MTLVDGKLAY--GKETQA 430
>PYRC_THETN (Q8R9R6) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 431
Score = 139 bits (351), Expect = 1e-32
Identities = 130/436 (29%), Positives = 203/436 (45%), Gaps = 36/436 (8%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
D+ IN G I +G K + +VID ++PG +D+H HL +PG E E TG
Sbjct: 21 DILINYG----IIKGIDKNIDVSDAIVIDAEGKYVLPGFVDMHTHLRQPGFEEKETIRTG 76
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVP-ENALNTS 175
T +AAAGG TTV MP N +P S+ ++ A+ E V V G + +
Sbjct: 77 TESAAAGGFTTVACMP-NTNPPIDSEVVVEYVKAVAQREGVVKVLPIGAMTKGMKGEEIT 135
Query: 176 ILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNN 235
+ L AGV+ L + FP+ + +K ++ Y ++ H E
Sbjct: 136 EMAKLKKAGVVALSD-------DGFPIMSAGIMKRVMTYGKMYDLLMITHCE-----DKT 183
Query: 236 LELKGNDDPRVYSTYLNTR--PPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSS 293
L +G + + +T L + P EE + + + K T GA +HI H+S
Sbjct: 184 LSGEGVMNSGIIATMLGLKGIPREAEEVMLARNIILAKAT-------GAKLHIAHVSTKG 236
Query: 294 VSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLE 353
S++LI+ AK G SI+ E H+L + E + + DT K PP+R + E L E + +
Sbjct: 237 -SVELIRRAKEEGVSITAEVTPHHLTRTDEAVYNYDTNTKVFPPLRTREDVEALIEGLKD 295
Query: 354 GHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSLL 412
G ID + +DH+ P K K+ + A GIS L+ V ++ + G +T++ L
Sbjct: 296 GTIDAIATDHA---PHTKDDKKVPYDMAPFGISGLETAFSVINTFLIQTGIITMKALVNY 352
Query: 413 WSQKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGK 472
S PA + GI++ I VG ADIV+ +P E+ + D F + Y G +L G
Sbjct: 353 MSMNPARILGISN--GIRVGATADIVIVNPHEEYTV--DKEKFKSKGKNTPYHGMKLKGV 408
Query: 473 VLDTFVRGNLVFKDGK 488
V T V G + ++ K
Sbjct: 409 VEYTIVEGQIRYQKNK 424
>PYRC_AQUAE (O66990) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 422
Score = 138 bits (347), Expect = 4e-32
Identities = 129/447 (28%), Positives = 211/447 (46%), Gaps = 44/447 (9%)
Query: 50 YTLNHSEDLE------INEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLD 103
Y ++ S++LE + GKI I K + +ID ++ PG ID+HVHL
Sbjct: 10 YVIDPSQNLEGEFDILVENGKIKKID----KNILVPEAEIIDAKGLIVCPGFIDIHVHLR 65
Query: 104 EPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHP---TTVSQETLQLKLEAAENELHVDV 160
+PG+T E +G+R A AGG TT+V MP N P TTV LQ V
Sbjct: 66 DPGQTYKEDIESGSRCAVAGGFTTIVCMPNTNPPIDNTTVVNYILQKS---------KSV 116
Query: 161 GFWGGLVPENALNTSILEGLLSAGVLGLKSFMCPSGIND-FPMTTIDHIKEGLSVLAKYR 219
G ++P + T +G A LK C + +D P+ +++ L + ++
Sbjct: 117 GLC-RVLPTGTI-TKGRKGKEIADFYSLKEAGCVAFTDDGSPVMDSSVMRKALELASQLG 174
Query: 220 RPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPL 279
P++ H E + + + N+ L++R P EE + + +D I
Sbjct: 175 VPIMDHCEDDKLAYGVI----NEGEVSALLGLSSRAPEAEE------IQIARDGIL-AQR 223
Query: 280 EGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIR 339
G HVHI H+S + +SL++I+ K +G I+ E ++L F+ E+ + + +PP+R
Sbjct: 224 TGGHVHIQHVS-TKLSLEIIEFFKEKGVKITCEVNPNHLLFTEREVLNSGANARVNPPLR 282
Query: 340 DAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYG 399
++ L E V G ID +DH+P K L E A GI LQ LP
Sbjct: 283 KKEDRLALIEGVKRGIIDCFATDHAPHQTFEKELVE----FAMPGIIGLQTALPSALELY 338
Query: 400 KKHGLTLEQLSLLWSQKPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHP 459
+K ++L++L +++ PA + G+ G + +G+ ADI ++ P E+ LN++ L
Sbjct: 339 RKGIISLKKLIEMFTINPARIIGV-DLGTLKLGSPADITIFDPNKEWILNEE--TNLSKS 395
Query: 460 NLSAYMGRRLSGKVLDTFVRGNLVFKD 486
+ G+ L GKV+ T G +V+KD
Sbjct: 396 RNTPLWGKVLKGKVIYTIKDGKMVYKD 422
>PYRC_STAEP (Q8CPJ6) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 425
Score = 133 bits (334), Expect = 1e-30
Identities = 110/413 (26%), Positives = 190/413 (45%), Gaps = 37/413 (8%)
Query: 83 VIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQ 142
VID +I PG +DVHVHL EPG E +GT+AAA GG TTV MP N P +
Sbjct: 43 VIDAKGNLIAPGFVDVHVHLREPGGEHKETIESGTKAAARGGFTTVCPMP-NTRPVPDTV 101
Query: 143 ETLQLKLEAAENELHVDVGFWGGLVPENALNTSI-LEGLLSAGVLGLKSFMCPSGINDFP 201
E ++ + V V + + A + E L GV G+
Sbjct: 102 EHVRELRQRISETAQVRVLPYAAITKRQAGTELVDFEKLALEGVFAFTD----DGVG--- 154
Query: 202 MTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEA 261
+ T + + K ++P++ H E D+ +Y ++ S E
Sbjct: 155 VQTASMMYAAMKQAVKVKKPIVAHCE--------------DNSLIYGGAMHKGKRSEELG 200
Query: 262 A-----IKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSH 316
I E V + +D + G H H+ H+S S+ +I++AK G ++ E H
Sbjct: 201 IPGIPNIAESVQIARDVLLA-EATGCHYHVCHVSTKE-SVRVIRDAKKAGIHVTAEVTPH 258
Query: 317 YLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKEG 376
+L + ++P D+ +K +PP+R ++E L E +L+G ID + +DH+P E K
Sbjct: 259 HLLLTENDVPGDDSNYKMNPPLRSNEDREALLEGLLDGTIDCIATDHAPHAKE---EKAQ 315
Query: 377 DFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSLLWSQKPATLAGIASKGAIVVGNHA 435
KA GI + P+ +++ + G +L+QL ++ KPAT+ + + G + ++A
Sbjct: 316 PMTKAPFGIVGSETAFPLLYTHFVRRGNWSLQQLVDYFTIKPATIFNL-NYGKLHKDSYA 374
Query: 436 DIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLDTFVRGNLVFKDGK 488
D+ + E E+ + FL + + ++G ++ G T ++G +VF++ K
Sbjct: 375 DLTIIDLNTEKEIKSE--DFLSKADNTPFIGEKVYGNPTLTMLKGEVVFEEEK 425
>PYRC_METTH (O27199) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 431
Score = 131 bits (329), Expect = 5e-30
Identities = 125/433 (28%), Positives = 205/433 (46%), Gaps = 40/433 (9%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
++ +++GKIV I+ +G ID ++PGLID HVH +PG E F TG
Sbjct: 18 NIGVDDGKIVQIS-----RGRIDASEKIDLKGYFVLPGLIDAHVHFRDPGLEYKEDFRTG 72
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
+ AAA GG +TV+DMP N P + + K+ E + VD G G + S
Sbjct: 73 SMAAAHGGFSTVLDMP-NTVPPADNAAEFERKIRIGERKSVVDFGLHAGF-----RSVSD 126
Query: 177 LEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQ-DSKNN 235
++G+L K FM +GI +T+D + L L+ P+ VH E + K+
Sbjct: 127 VKGILRFMPASFKVFMDLTGI-----STVDGLFRELKDLSA-PVPVTVHCENRDVVMKSM 180
Query: 236 LELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVS 295
ELK DP S Y RPP EE ++ E++ ++ H VHI HLS + +
Sbjct: 181 KELKDRSDP---SAYALARPPLAEEVSVAEVLALSIHHEH-------PVHICHLS-TVKA 229
Query: 296 LDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGH 355
L L++ + + ++ E H+L S T K +PP+R + +++ L+
Sbjct: 230 LQLVEPFR---EYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPP--ESRIYPEFLD-R 283
Query: 356 IDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHGLTLEQLSLLWSQ 415
I+++ +DH+P E K ++G A GI +L+ L + + K ++L + + ++
Sbjct: 284 INIIGTDHAPHGIEEK--RKG-IWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRMLAE 340
Query: 416 KPATLAGIASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLD 475
+PA + G+ SKG I G AD V + + D F + + + G +G +
Sbjct: 341 EPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSD--EFYSKAHYTPFEGFSYTGGPVM 398
Query: 476 TFVRGNLVFKDGK 488
T VRG V +DG+
Sbjct: 399 TIVRGRAVMRDGE 411
>PYRC_HALN1 (Q9HMH9) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 422
Score = 130 bits (327), Expect = 8e-30
Identities = 105/361 (29%), Positives = 169/361 (46%), Gaps = 28/361 (7%)
Query: 91 IMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLE 150
++PG+ID HVH +PG E + +G+R+AAAGGVTTVVD P N P TV+ + + K
Sbjct: 45 VLPGMIDAHVHFRQPGFEHKETWASGSRSAAAGGVTTVVDQP-NTAPPTVTGDAVDEKAA 103
Query: 151 AAENELHVDVGFWGGLVPENALNTSILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKE 210
A + VD G GG+ E + L + G + L GI+ ++
Sbjct: 104 HAAADSVVDWGVNGGVTGEWDPASLFDRSLFALGEVFLADSTGDMGID------AALFRD 157
Query: 211 GLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVT 270
A + VHAE + + K D +S Y R P E AA++ V+V
Sbjct: 158 ACQRAASEDVVVTVHAE--DADRFDTAAKSRSDADAWSAY---RTPEAEAAAVERAVEV- 211
Query: 271 KDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGDT 330
G GA +HI H S + + + A G + E H+L S +++ D T
Sbjct: 212 ------GTEAGATIHIAHTS----TPEGVDAAAAGG--ATCEATPHHLFLSRDDLDDLGT 259
Query: 331 RFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQF 390
+ +PP+R +E L+E + +G ID++ +DH+ P + K D A G+ ++
Sbjct: 260 FGRMNPPLRSDPRREALFERLADGRIDVVATDHA---PHTRAEKAADIWDAPSGVPGVET 316
Query: 391 DLPVTWSYGKKHGLTLEQLSLLWSQKPATLAGIASKGAIVVGNHADIVVWHPELEFELND 450
LP+ + L+ E++ + + PA + G+ KG I G AD+V+ P+ E++
Sbjct: 317 ALPLLLGAAHRGELSYERVRDVTAANPADVFGLERKGHIAAGRDADLVLVDPDDAREIHG 376
Query: 451 D 451
D
Sbjct: 377 D 377
>HYDA_BACST (Q45515) D-hydantoinase (EC 3.5.2.2)
(Dihydropyrimidinase) (DHPase)
Length = 471
Score = 130 bits (327), Expect = 8e-30
Identities = 132/451 (29%), Positives = 207/451 (45%), Gaps = 45/451 (9%)
Query: 54 HSEDLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEP--GRTEWE 111
+ DL I +GKI I + G VID + PG ID H HLD P G +
Sbjct: 17 YEADLLIQDGKIAVIGRNLDESGAE----VIDATGCYVFPGGIDPHTHLDMPFGGTVTKD 72
Query: 112 GFVTGTRAAAAGGVTTVVDMPLNN--HPTTVSQETLQLKLEAAENELHVDVGFWGGLVPE 169
F +GT AAA GG TT++D L N P + ET K A + +D GF +
Sbjct: 73 DFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNK---ATGKAVIDYGFH---LMI 126
Query: 170 NALNTSILEGLLSA----GVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVH 225
+ + +LE L G+ K FM + T+ L ++VH
Sbjct: 127 SEITDDVLEELPKVIEEEGITSFKVFMAYKDVFQADDGTLYRTLVAAKELGAL---VMVH 183
Query: 226 AE----IQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEG 281
AE I +K LE G+ DP ++ TRPP E A +T+ L G
Sbjct: 184 AENGDVIDYLTKKALE-DGHTDPIYHAL---TRPPELEGEATGRACQLTE-------LAG 232
Query: 282 AHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCSHYLAFSSE--EIPDGD-TRFKCSPPI 338
+ +++VH+S + +++ I EA+ +G ++ ETC YL E P+ + ++ SPP+
Sbjct: 233 SQLYVVHVSCAQ-AVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPL 291
Query: 339 RDAFNKEKLWEAVLEGHIDLLTSDH-SPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWS 397
R+ +++E LW A+ G + L SD S K L GDF K G ++ + + +S
Sbjct: 292 REKWHQEVLWNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFS 351
Query: 398 YGKKHG-LTLEQLSLLWSQKPATLAGI-ASKGAIVVGNHADIVVWHPELEFELNDDYPVF 455
G K G +TL Q + S + A L G+ KG I VG AD+V++ P +E ++ +
Sbjct: 352 EGVKKGRITLNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAE--TH 409
Query: 456 LKHPNLSAYMGRRLSGKVLDTFVRGNLVFKD 486
+ + + G +++G+ + RG V +D
Sbjct: 410 HMAVDYNPFEGMKVTGEPVSVLCRGEFVVRD 440
>HYDA_AGRTU (Q44184) D-hydantoinase (EC 3.5.2.2)
(Dihydropyrimidinase) (DHPase)
Length = 457
Score = 126 bits (317), Expect = 1e-28
Identities = 120/444 (27%), Positives = 196/444 (44%), Gaps = 28/444 (6%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPG--RTEWEGFV 114
DL I +GKI I +G G + ID + PG IDVH H++ + F
Sbjct: 20 DLGIKDGKIAQIGGTFGPAGRT-----IDASGRYVFPGGIDVHTHVETVSFNTQSADTFA 74
Query: 115 TGTRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNT 174
T T AAA GG TT+VD + ++ + + A + +D G+ ++
Sbjct: 75 TATVAAACGGTTTIVDFCQQDRGHSLREAVAKWD-GMAGGKSAIDYGYHIIVLDPTDSVI 133
Query: 175 SILEGLLSAGVLGLKSFMCPSGINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKN 234
LE L G+ K FM G+N T+ L AK ++VHAE D+ +
Sbjct: 134 EELEVLPDLGITSFKVFMAYRGMNMIDDVTL---LRTLDKAAKTGSLVMVHAE-NGDAAD 189
Query: 235 NLELKGNDDPRVYSTY-LNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHLSDSS 293
L K D + Y +RPP E A + + + + A ++IVHL+
Sbjct: 190 YLRDKFVADGKTAPIYHALSRPPRVEAEATARALALAE-------IVNAPIYIVHLTCEE 242
Query: 294 VSLDLIKEAKLRGDSISVETCSHYLAFSSEEIPDGD---TRFKCSPPIRDAFNKEKLWEA 350
S D + AK RG ETC+ YL + +++ D ++ +PP R ++E LW A
Sbjct: 243 -SFDELMRAKARGVHALAETCTQYLYLTKDDLERPDFEGAKYVFTPPPRTKKDQEILWNA 301
Query: 351 VLEGHIDLLTSDHSPTVPE-LKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHGLTLEQL 409
+ G ++ ++SDH + E K DF G ++ L + + + ++L Q
Sbjct: 302 LRNGVLETVSSDHCSWLFEGHKDRGRNDFRAIPNGAPGVEERLMMVYQGVNEGRISLTQF 361
Query: 410 SLLWSQKPATLAGI-ASKGAIVVGNHADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRR 468
L + +PA + G+ KG + VG+ ADIV+W PE E + + + S+Y G +
Sbjct: 362 VELVATRPAKVFGMFPEKGTVAVGSDADIVLWDPEAEMVI--EQSAMHNAMDYSSYEGHK 419
Query: 469 LSGKVLDTFVRGNLVFKDGKHAPA 492
+ G +RG ++ +G + A
Sbjct: 420 IKGVPKTVLLRGKVIVDEGTYVGA 443
>PYRC_METAC (Q8TSA6) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 467
Score = 125 bits (313), Expect = 3e-28
Identities = 119/400 (29%), Positives = 188/400 (46%), Gaps = 42/400 (10%)
Query: 57 DLEINEGKIVSITEGYGKQGNSKQEVVIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTG 116
++ I GKI I + + S ++VID A+ +P IDVHVH EPG T E + TG
Sbjct: 21 EILIENGKITKIGKDFRV---SSSDMVIDAEGALTLPAGIDVHVHFREPGMTLKENWYTG 77
Query: 117 TRAAAAGGVTTVVDMPLNNHPTTVSQETLQLKLEAAENELHVDVGFWGGLVPENALNTSI 176
+ AAAAGG+ TV+D P N P T + + + KL+ A + VD G GG+ N
Sbjct: 78 SCAAAAGGIATVIDQP-NTIPPTTDRRSFEQKLKLARKKSIVDFGINGGVTG----NIEK 132
Query: 177 LEGLLSAGVLGL-KSFMCPS--GINDFPMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSK 233
L L GV + FM S G+N + +E L+ + K +HAE D K
Sbjct: 133 LRELWRLGVTAFGEIFMAESTGGLN----INEETFEEALAEIKKLGALATIHAE---DEK 185
Query: 234 NNLE----LKGNDDPRVYSTYLNTRPPSWEEAAIKELVDVTKDTIHGGPLEGAHVHIVHL 289
LE LKG+ Y + RP + E +A++ +++ H HL
Sbjct: 186 MRLELEQLLKGDVS---YDYHSKVRPNACEASAVQSALELISRL-------QVRAHFCHL 235
Query: 290 SDSSVSLDLIKEAKL--RGDSISVETCS---HYLAFSSEEIPDGDTRFKCSPPIRDAFNK 344
S + KE L R + + TC H+L S+++ K +PP+R + +
Sbjct: 236 STLEAVGMIRKEKYLAKRENKKPLFTCEVTPHHLFLSAKDWERLRAFGKMNPPLRGSHSI 295
Query: 345 EKLWEAVLEGHIDLLTSDHSPTVPELKLLKEGDFLKAWGGISSLQFDLPVTWSYGKKHGL 404
+ L + +G ID++ SDH+ P L+ K+ D A G+ ++ +P+ + +K+ L
Sbjct: 296 KALVNGLNDGTIDMVASDHA---PHLESEKDLDIRAAPSGVPGVETLMPLMLAAVRKNIL 352
Query: 405 TLEQLSLLWSQKPATLAGI--ASKGAIVVGNHADIVVWHP 442
L Q+ ++ S PA G+ KG + VG AD+++ P
Sbjct: 353 PLSQMIMVTSWNPAKAFGLDRLGKGWLEVGFDADLMIVDP 392
>PYRC_STAAW (P65907) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 424
Score = 124 bits (312), Expect = 4e-28
Identities = 109/414 (26%), Positives = 186/414 (44%), Gaps = 39/414 (9%)
Query: 83 VIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQ 142
+ID + PG +DVHVHL EPG E TGT+AAA GG TTV MP N P S
Sbjct: 42 IIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAARGGFTTVCPMP-NTRPVPDSV 100
Query: 143 ETLQLKLEAAENELHVDVGFWGGLVPENALNTSILE--GLLSAGVLGLKSFMCPSGINDF 200
E + + ++ V V + + L +++ L+ G G+
Sbjct: 101 EHFEALQKLIDDNAQVRVLPYASITTRQ-LGKELVDFPALVKEGAFAFTD----DGVG-- 153
Query: 201 PMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEE 260
+ T + EG+ AK + ++ H E D+ +Y ++ S E
Sbjct: 154 -VQTASMMYEGMIEAAKVNKAIVAHCE--------------DNSLIYGGAMHEGKRSKEL 198
Query: 261 AA-----IKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCS 315
I E V + +D + G H H+ H+S S+ +I++AK G ++ E
Sbjct: 199 GIPGIPNICESVQIARDVLLA-EAAGCHYHVCHVSTKE-SVRVIRDAKRAGIHVTAEVTP 256
Query: 316 HYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKE 375
H+L + ++IP + +K +PP+R ++E L E +L+G ID + +DH+P + K
Sbjct: 257 HHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARD---EKA 313
Query: 376 GDFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSLLWSQKPATLAGIASKGAIVVGNH 434
KA GI + P+ +++ K+G TL+QL + KP + G + +
Sbjct: 314 QPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNL-EYGTLKENGY 372
Query: 435 ADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLDTFVRGNLVFKDGK 488
AD+ + + E E+ + FL + + ++G ++ G + T V G + F+ K
Sbjct: 373 ADLTIIDLDSEQEIKGE--DFLSKADNTPFIGYKVYGNPILTMVEGEVKFEGDK 424
>PYRC_STAAN (P65906) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 424
Score = 124 bits (312), Expect = 4e-28
Identities = 109/414 (26%), Positives = 186/414 (44%), Gaps = 39/414 (9%)
Query: 83 VIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQ 142
+ID + PG +DVHVHL EPG E TGT+AAA GG TTV MP N P S
Sbjct: 42 IIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAARGGFTTVCPMP-NTRPVPDSV 100
Query: 143 ETLQLKLEAAENELHVDVGFWGGLVPENALNTSILE--GLLSAGVLGLKSFMCPSGINDF 200
E + + ++ V V + + L +++ L+ G G+
Sbjct: 101 EHFEALQKLIDDNAQVRVLPYASITTRQ-LGKELVDFPALVKEGAFAFTD----DGVG-- 153
Query: 201 PMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEE 260
+ T + EG+ AK + ++ H E D+ +Y ++ S E
Sbjct: 154 -VQTASMMYEGMIEAAKVNKAIVAHCE--------------DNSLIYGGAMHEGKRSKEL 198
Query: 261 AA-----IKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCS 315
I E V + +D + G H H+ H+S S+ +I++AK G ++ E
Sbjct: 199 GIPGIPNICESVQIARDVLLA-EAAGCHYHVCHVSTKE-SVRVIRDAKRAGIHVTAEVTP 256
Query: 316 HYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKE 375
H+L + ++IP + +K +PP+R ++E L E +L+G ID + +DH+P + K
Sbjct: 257 HHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARD---EKA 313
Query: 376 GDFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSLLWSQKPATLAGIASKGAIVVGNH 434
KA GI + P+ +++ K+G TL+QL + KP + G + +
Sbjct: 314 QPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNL-EYGTLKENGY 372
Query: 435 ADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLDTFVRGNLVFKDGK 488
AD+ + + E E+ + FL + + ++G ++ G + T V G + F+ K
Sbjct: 373 ADLTIIDLDSEQEIKGE--DFLSKADNTPFIGYKVYGNPILTMVEGEVKFEGDK 424
>PYRC_STAAM (P65905) Dihydroorotase (EC 3.5.2.3) (DHOase)
Length = 424
Score = 124 bits (312), Expect = 4e-28
Identities = 109/414 (26%), Positives = 186/414 (44%), Gaps = 39/414 (9%)
Query: 83 VIDYGEAVIMPGLIDVHVHLDEPGRTEWEGFVTGTRAAAAGGVTTVVDMPLNNHPTTVSQ 142
+ID + PG +DVHVHL EPG E TGT+AAA GG TTV MP N P S
Sbjct: 42 IIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAARGGFTTVCPMP-NTRPVPDSV 100
Query: 143 ETLQLKLEAAENELHVDVGFWGGLVPENALNTSILE--GLLSAGVLGLKSFMCPSGINDF 200
E + + ++ V V + + L +++ L+ G G+
Sbjct: 101 EHFEALQKLIDDNAQVRVLPYASITTRQ-LGKELVDFPALVKEGAFAFTD----DGVG-- 153
Query: 201 PMTTIDHIKEGLSVLAKYRRPLLVHAEIQQDSKNNLELKGNDDPRVYSTYLNTRPPSWEE 260
+ T + EG+ AK + ++ H E D+ +Y ++ S E
Sbjct: 154 -VQTASMMYEGMIEAAKVNKAIVAHCE--------------DNSLIYGGAMHEGKRSKEL 198
Query: 261 AA-----IKELVDVTKDTIHGGPLEGAHVHIVHLSDSSVSLDLIKEAKLRGDSISVETCS 315
I E V + +D + G H H+ H+S S+ +I++AK G ++ E
Sbjct: 199 GIPGIPNICESVQIARDVLLA-EAAGCHYHVCHVSTKE-SVRVIRDAKRAGIHVTAEVTP 256
Query: 316 HYLAFSSEEIPDGDTRFKCSPPIRDAFNKEKLWEAVLEGHIDLLTSDHSPTVPELKLLKE 375
H+L + ++IP + +K +PP+R ++E L E +L+G ID + +DH+P + K
Sbjct: 257 HHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARD---EKA 313
Query: 376 GDFLKAWGGISSLQFDLPVTWSYGKKHG-LTLEQLSLLWSQKPATLAGIASKGAIVVGNH 434
KA GI + P+ +++ K+G TL+QL + KP + G + +
Sbjct: 314 QPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNL-EYGTLKENGY 372
Query: 435 ADIVVWHPELEFELNDDYPVFLKHPNLSAYMGRRLSGKVLDTFVRGNLVFKDGK 488
AD+ + + E E+ + FL + + ++G ++ G + T V G + F+ K
Sbjct: 373 ADLTIIDLDSEQEIKGE--DFLSKADNTPFIGYKVYGNPILTMVEGEVKFEGDK 424
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,225,184
Number of Sequences: 164201
Number of extensions: 2825802
Number of successful extensions: 7354
Number of sequences better than 10.0: 137
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 7049
Number of HSP's gapped (non-prelim): 204
length of query: 501
length of database: 59,974,054
effective HSP length: 114
effective length of query: 387
effective length of database: 41,255,140
effective search space: 15965739180
effective search space used: 15965739180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Lotus: description of TM0336.15