BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0335a.3
(479 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
NSDL_HUMAN (Q15738) NAD(P)-dependent steroid dehydrogenase (EC 1... 158 3e-38
NSDL_MOUSE (Q9R1J0) NAD(P)-dependent steroid dehydrogenase (EC 1... 155 2e-37
ER26_YEAST (P53199) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 148 3e-35
3BH7_MOUSE (Q9EQC1) 3 beta-hydroxysteroid dehydrogenase type VII... 135 2e-31
3BH7_HUMAN (Q9H2F3) 3 beta-hydroxysteroid dehydrogenase type VII... 132 2e-30
3BH1_RAT (P22071) 3 beta-hydroxysteroid dehydrogenase/delta 5-->... 121 5e-27
3BH2_RAT (P22072) 3 beta-hydroxysteroid dehydrogenase/delta 5-->... 120 1e-26
3BHS_FOWPV (Q67477) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 118 3e-26
3BH6_MOUSE (O35469) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 115 2e-25
3BH1_MOUSE (P24815) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 113 1e-24
3BH2_MOUSE (P26149) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 112 3e-24
3BH1_MESAU (Q60555) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 111 4e-24
3BH4_RAT (Q62878) 3 beta-hydroxysteroid dehydrogenase/delta 5-->... 110 6e-24
3BH2_MESAU (Q64421) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 110 1e-23
3BH3_MOUSE (P26150) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 106 1e-22
3BHS_MACMU (P27365) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 103 1e-21
3BH2_HUMAN (P26439) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 102 3e-21
3BH1_HUMAN (P14060) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 98 4e-20
3BH3_MESAU (O35296) 3 beta-hydroxysteroid dehydrogenase type III... 96 2e-19
3BHS_BOVIN (P14893) 3 beta-hydroxysteroid dehydrogenase/delta 5-... 96 3e-19
>NSDL_HUMAN (Q15738) NAD(P)-dependent steroid dehydrogenase (EC
1.1.1.-) (H105e3 protein)
Length = 373
Score = 158 bits (399), Expect = 3e-38
Identities = 115/369 (31%), Positives = 182/369 (49%), Gaps = 34/369 (9%)
Query: 10 EGKTLVVTGGLGFVGSALCLELVRRGAHEVRAFDLRDSSPWFAILKDNGVRCIQGDIVRK 69
+ K V GG GF+G + +L+ RG + V FD++ + VR GD+ +
Sbjct: 36 QAKRCTVIGGSGFLGQHMVEQLLARG-YAVNVFDIQQG------FDNPQVRFFLGDLCSR 88
Query: 70 EDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLVYCST 129
+D+ AL+G + VFH A+ S RV N GT +V++ C G+++L+ S+
Sbjct: 89 QDLYPALKGVNTVFHCASPPPSSNNKELFYRV---NYIGTKNVIETCKEAGVQKLILTSS 145
Query: 130 YNVVFAGQRIVNGNESLPYF--PIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAGNCLYT 187
+V+F G I NG E LPY PID+ Y +K + E+ VL N P KN T
Sbjct: 146 ASVIFEGVDIKNGTEDLPYAMKPIDY----YTETKILQERAVLGAND-PEKN-----FLT 195
Query: 188 CAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILASMGLL 247
A+RP I+GP + + +P +I A+ G + F IG+ D+ FVEN+V ILA+ L
Sbjct: 196 TAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLS 255
Query: 248 DDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAVDHALVLGRIC 307
DS G+A+ I++ P+ + FL +L L YE PK + A L +
Sbjct: 256 RDST--------LGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLL 307
Query: 308 QGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSSREGMASTI 367
+ ++ P + QP P V G HY+S +AK+ +GY P+V+ + M T+
Sbjct: 308 SLLVMVISPVIQL----QPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAMERTV 363
Query: 368 SYWQQRKMI 376
++ + +
Sbjct: 364 QSFRHLRRV 372
>NSDL_MOUSE (Q9R1J0) NAD(P)-dependent steroid dehydrogenase (EC
1.1.1.-)
Length = 362
Score = 155 bits (392), Expect = 2e-37
Identities = 122/378 (32%), Positives = 187/378 (49%), Gaps = 40/378 (10%)
Query: 2 HLSENEGIEGKTLVVTGGLGFVGSALCLELVRRGAHEVRAFDLRDSSPWFAILKDNGVRC 61
HL+ N+ + K V GG GF+G + +L+ RG + V FD+ + V+
Sbjct: 18 HLT-NDISKAKKCTVIGGSGFLGQHMVEQLLERG-YTVNVFDIHQG------FDNPRVQF 69
Query: 62 IQGDIVRKEDVESALRGADCVFHLAAFG--MSGKEMLQLTRVDQVNITGTCHVLDACLHL 119
GD+ ++D+ AL+G VFH A+ + KE+ +VN GT V++ C
Sbjct: 70 FIGDLCNQQDLYPALKGVSTVFHCASPPPYSNNKELFY-----RVNFIGTKTVIETCREA 124
Query: 120 GIKRLVYCSTYNVVFAGQRIVNGNESLPYF--PIDHHVDPYGRSKSIAEQLVLKNNARPF 177
G+++L+ S+ +VVF G I NG E LPY PID+ Y +K + E+ VL N P
Sbjct: 125 GVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDY----YTETKILQERAVLDAND-PK 179
Query: 178 KNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVL 237
KN T A+RP I+GP + + +P +I A+ G + F IG+ D+ FVEN+V
Sbjct: 180 KN-----FLTAAIRPHGIFGPRDPQLVPILIDAARKGKMKFMIGNGENLVDFTFVENVVH 234
Query: 238 ALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAV 297
ILA+ L D+A G+A+ I++ P+ + FL +L L YE PK +
Sbjct: 235 GHILAAEHLSQDAA--------LGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPY 286
Query: 298 DHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMV 357
A L + + ++ P + QP P V G HY+S KAK+ GY P+V
Sbjct: 287 WMAYYLAFLLSLLVMVVSPLIQ----IQPTFTPIRVALAGTFHYYSCEKAKKLFGYRPLV 342
Query: 358 SSREGMASTI-SYWQQRK 374
+ E + T+ S+ RK
Sbjct: 343 TMDEAVERTVQSFHHLRK 360
>ER26_YEAST (P53199) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase (3Beta-HSD) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delta-isomera
Length = 349
Score = 148 bits (374), Expect = 3e-35
Identities = 114/370 (30%), Positives = 186/370 (49%), Gaps = 38/370 (10%)
Query: 13 TLVVTGGLGFVGSALCLELVRRGAH-EVRAFDLRDS----SPWFAILKDNGVRCIQGDIV 67
++++ GG GF+G L + ++ FD+RD S F D+ ++ +GD+
Sbjct: 6 SVLIIGGSGFLGLHLIQQFFDINPKPDIHIFDVRDLPEKLSKQFTFNVDD-IKFHKGDLT 64
Query: 68 RKEDVESALRG--ADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
+D+E+A+ A+ V H A+ M G+ D VN+ GT +V+D C G+ LV
Sbjct: 65 SPDDMENAINESKANVVVHCAS-PMHGQNP---DIYDIVNVKGTRNVIDMCKKCGVNILV 120
Query: 126 YCSTYNVVFAGQRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAGNCL 185
Y S+ V+F GQ + N +E+ P + +D Y +K+IAE +VLK ND +
Sbjct: 121 YTSSAGVIFNGQDVHNADETWPIPEVP--MDAYNETKAIAEDMVLK------ANDPSSDF 172
Query: 186 YTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILASMG 245
YT A+RPA I+GPG+ + +P + AKLG F IGD DW + N+ A +LA+
Sbjct: 173 YTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQK 232
Query: 246 LLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAVDHALVLGR 305
LLD K R +G+ +FI++ +P + + + ++ + + K H +VL R
Sbjct: 233 LLDP-----KTRTAVSGETFFITNDTPTYFWALARTVWKA-DGHIDK------HVIVLKR 280
Query: 306 ---ICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSSREG 362
IC G L W+ + +P + P V V Y + KAK+ +GY P V EG
Sbjct: 281 PVAICAG---YLSEWVSKMLGKEPGLTPFRVKIVCAYRYHNIAKAKKLLGYTPRVGIEEG 337
Query: 363 MASTISYWQQ 372
+ T+++ +
Sbjct: 338 INKTLAWMDE 347
>3BH7_MOUSE (Q9EQC1) 3 beta-hydroxysteroid dehydrogenase type VII
(3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid
oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD)
Length = 369
Score = 135 bits (340), Expect = 2e-31
Identities = 120/370 (32%), Positives = 167/370 (44%), Gaps = 33/370 (8%)
Query: 15 VVTGGLGFVGSALCLELVRRGAH--EVRAFDLRDSSPWFAILKDNGVR--CIQGDIVRKE 70
+VTGG GF+G + L+ R E+R FDL SS W LK V+ IQGD+ +
Sbjct: 13 LVTGGCGFLGEHIVRMLLEREPRLRELRVFDLHLSS-WLEELKAGPVQVTAIQGDVTQAH 71
Query: 71 DVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLVY 126
+V +A+ G+ V H A FG + + + +VN+ GT +V+DAC+ G + LVY
Sbjct: 72 EVAAAMSGSHVVIHTAGLVDVFGKASPKTIH-----KVNVQGTQNVIDACVQTGTQYLVY 126
Query: 127 CSTYNVV---FAGQRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAGN 183
S+ VV G GNE PY + H PY SK++AEQLVL+ N R K + G
Sbjct: 127 TSSMEVVGPNIKGHPFYRGNEDTPYEAVHSH--PYPCSKALAEQLVLEANGR--KVNGGL 182
Query: 184 CLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILAS 243
L TCA+RP IYG G + G LF +V+ V+V N+ IL +
Sbjct: 183 PLVTCALRPTGIYGEGHQVMRDFYYQGLRFGGRLFRAVPASVEHGRVYVGNVAWMHILVA 242
Query: 244 MGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFE-FLQPLLRSLEYELPKTSLAVDHALV 302
L +A + GQ YF D SP ++E F L L + + L+
Sbjct: 243 RELEQRAA-------LMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGAHPLLPYWLL 295
Query: 303 LGRICQGVYTILYPWLDR-WWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSSRE 361
+ L WL R L P + P + T S KA+ GY P+ S E
Sbjct: 296 ---VLLATLNALLQWLLRPLVLYTPLLNPYTLAMANTTFTVSTNKAQRHFGYKPLFSWEE 352
Query: 362 GMASTISYWQ 371
TI + Q
Sbjct: 353 SRTRTIQWVQ 362
>3BH7_HUMAN (Q9H2F3) 3 beta-hydroxysteroid dehydrogenase type VII
(3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid
oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD)
Length = 369
Score = 132 bits (332), Expect = 2e-30
Identities = 118/370 (31%), Positives = 168/370 (44%), Gaps = 33/370 (8%)
Query: 15 VVTGGLGFVGSALCLELVRRGAH--EVRAFDLRDSSPWFAILKDNGVR--CIQGDIVRKE 70
+VTGG GF+G + L++R E+R FD + PW LK VR IQGD+ +
Sbjct: 13 LVTGGCGFLGEHVVRMLLQREPRLGELRVFD-QHLGPWLEELKTGPVRVTAIQGDVTQAH 71
Query: 71 DVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLVY 126
+V +A+ GA V H A FG + + + +VN+ GT +V++AC+ G + LVY
Sbjct: 72 EVAAAVAGAHVVIHTAGLVDVFGRASPKTIH-----EVNVQGTRNVIEACVQTGTRFLVY 126
Query: 127 CSTYNVV---FAGQRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAGN 183
S+ VV G GNE PY + H PY SK++AE LVL+ N R K G
Sbjct: 127 TSSMEVVGPNTKGHPFYRGNEDTPYEAVHRH--PYPCSKALAEWLVLEANGR--KVRGGL 182
Query: 184 CLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILAS 243
L TCA+RP IYG G +LG LF +V+ V+V N+ +LA+
Sbjct: 183 PLVTCALRPTGIYGEGHQIMRDFYRQGLRLGGWLFRAIPASVEHGRVYVGNVAWMHVLAA 242
Query: 244 MGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFE-FLQPLLRSLEYELPKTSLAVDHALV 302
L ++ + GQ YF DGSP ++E F L L + + L+
Sbjct: 243 REL-------EQRATLMGGQVYFCYDGSPYRSYEDFNMEFLGPCGLRLVGARPLLPYWLL 295
Query: 303 LGRICQGVYTILYPWLDR-WWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSSRE 361
+ L WL R L P + P + T S KA+ GY P+ S +
Sbjct: 296 ---VFLAALNALLQWLLRPLVLYAPLLNPYTLAVANTTFTVSTDKAQRHFGYEPLFSWED 352
Query: 362 GMASTISYWQ 371
TI + Q
Sbjct: 353 SRTRTILWVQ 362
>3BH1_RAT (P22071) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type I (3Beta-HSD I) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delta-
Length = 372
Score = 121 bits (303), Expect = 5e-27
Identities = 118/378 (31%), Positives = 181/378 (47%), Gaps = 42/378 (11%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL---RDSSPWFAILKDNG-VRCIQGD 65
G + +VTG GFVG + LV+ + EVRA D ++ F+ L+ V ++GD
Sbjct: 2 GWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + +L + VN+ GT ++L+AC+ + +
Sbjct: 62 ILDAQYLRRACQGISVVIHTAAV-IDVSHVLPRQTILDVNLKGTQNILEACVEASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHH----VDPYGRSKSIAEQLVLKNNARPFK 178
YCST +V + I+NG+E +HH D Y SK +AE+ VL N K
Sbjct: 121 YCSTVDVAGPNSYKKIILNGHEE------EHHESTWSDAYPYSKRMAEKAVLAANGSILK 174
Query: 179 NDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLA 238
N G L+TCA+RP IYG I+ K +L G ++ + V+V N+ A
Sbjct: 175 N--GGTLHTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKFSIANP-VYVGNVAWA 231
Query: 239 LILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PKTSL 295
ILA+ GL D + Q GQ Y+ISD +P +++ L L S E+ L SL
Sbjct: 232 HILAARGLRDPKKSQNVQ-----GQFYYISDDTPHQSYDDLNCTL-SKEWGLRLDSSWSL 285
Query: 296 AVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKAKEEIG 352
+ L + + V +L P+ + + P H V +++ FSY KA+ ++G
Sbjct: 286 PLPLLYWLAFLLETVSFLLRPFYN-------YRPPFNCHLVTLSNSKFTFSYKKAQRDLG 338
Query: 353 YVPMVSSREGMASTISYW 370
YVP+VS E T S W
Sbjct: 339 YVPLVSWEEAKQKT-SEW 355
>3BH2_RAT (P22072) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type II (3Beta-HSD II) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delt
Length = 372
Score = 120 bits (300), Expect = 1e-26
Identities = 118/378 (31%), Positives = 181/378 (47%), Gaps = 42/378 (11%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL---RDSSPWFAILKDNG-VRCIQGD 65
G + +VTG GFVG + LV+ + EVRA D ++ F+ L+ V ++GD
Sbjct: 2 GWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H A+ M +L + VN+ GT ++L+A +H + +
Sbjct: 62 ILDAQYLRRACQGISVVIHTASV-MDFSRVLPRQTILDVNLKGTQNLLEAGIHASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHH----VDPYGRSKSIAEQLVLKNNARPFK 178
YCST +V + I+NG E +HH +PY SK +AE+ VL N K
Sbjct: 121 YCSTVDVAGPNSYKKTILNGREE------EHHESTWSNPYPYSKKMAEKAVLAANGSILK 174
Query: 179 NDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLA 238
N G L+TCA+RP IYG + L RII A + + + + V+V N+ A
Sbjct: 175 N--GGTLHTCALRPMYIYGE-RGQFLSRIIIMALKNKGVLNVTGKFSIVNPVYVGNVAWA 231
Query: 239 LILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PKTSL 295
ILA+ GL D + Q GQ Y+ISD +P +++ L L S E+ L SL
Sbjct: 232 HILAARGLRDPKKSQNIQ-----GQFYYISDDTPHQSYDDLNCTL-SKEWGLRLDSSWSL 285
Query: 296 AVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKAKEEIG 352
+ L + + V +L P+ + + P H V +++ FSY KA+ ++G
Sbjct: 286 PLPLLYWLAFLLETVSFLLRPFYN-------YRPPFNCHLVTLSNSKFTFSYKKAQRDLG 338
Query: 353 YVPMVSSREGMASTISYW 370
Y P+VS E T S W
Sbjct: 339 YEPLVSWEEAKQKT-SEW 355
>3BHS_FOWPV (Q67477) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase (3Beta-HSD) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delta-isomera
Length = 370
Score = 118 bits (296), Expect = 3e-26
Identities = 104/365 (28%), Positives = 172/365 (46%), Gaps = 32/365 (8%)
Query: 15 VVTGGLGFVGSALCLELV--RRGAHEVRAFDLRDSSPWFAIL--KDNGVRCIQ--GDIVR 68
VVTGG GF+G + L+ EVR +D+R W L K N ++ + GD+
Sbjct: 7 VVTGGCGFLGRHIINNLILFESSLKEVRVYDIRIDQ-WLLDLVEKCNIIKIVPVIGDVRN 65
Query: 69 KEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLVYCS 128
K ++ ALR AD V H+A+ + + +D VNI GT +V+D+CL+ G++ LVY S
Sbjct: 66 KSTLDEALRSADVVIHIASINDVAGKFTNDSIMD-VNINGTKNVVDSCLYNGVRVLVYTS 124
Query: 129 TYNVV---FAGQRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAGNCL 185
+Y+ V F G ++ GNE+ Y +H + Y SK ++E+ +L+ N ++ G L
Sbjct: 125 SYSAVGPNFLGDAMIRGNENTYY--QSNHKEAYPLSKQLSEKYILEANGT--MSNIGLRL 180
Query: 186 YTCAVRPAAIYGPGEDRHLPRIITTAKLGL---LLFTIGDQTVKSDWVFVENLVLALILA 242
TCA+RP ++G + P + T + ++ D V V+ N+ ILA
Sbjct: 181 CTCALRPLGVFG----EYCPVLETLYRRSYKSRKMYKYADDKVFHSRVYAGNVAWMHILA 236
Query: 243 SMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTF-EFLQPLLRSLEYELPKTSLAVDHAL 301
+ ++++ G+ P+ Y+ D SP + +F L +L T L +
Sbjct: 237 ARNMIEN----GQHSPL-CNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRNTCLPLWCLR 291
Query: 302 VLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSSRE 361
+ I +G+ +L P L P+ L E T KA ++ GYVP+ + E
Sbjct: 292 FIANINKGLRVLLSPICSYTPLLNPYTLIKEC----TTFTIETDKAFKDFGYVPLYTWEE 347
Query: 362 GMAST 366
+ T
Sbjct: 348 SRSKT 352
>3BH6_MOUSE (O35469) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type VI (3Beta-HSD VI) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid de
Length = 372
Score = 115 bits (288), Expect = 2e-25
Identities = 113/377 (29%), Positives = 175/377 (45%), Gaps = 40/377 (10%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + L++ + E+R D +F + + V ++GD
Sbjct: 2 GWSCLVTGAGGFLGQRIVQLLMQEKDLEEIRVLDKFFRPETREQFFNLDTNIKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + ++ + VN+ GT ++L+AC+ + +
Sbjct: 62 ILDTQYLRKACQGISVVIHTAAV-IDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHHV----DPYGRSKSIAEQLVLKNNARPFK 178
+ S+ +V + I+NGNE +HH DPY SK +AE+ VL N K
Sbjct: 121 FSSSVDVAGPNSYKEIILNGNEE------EHHESIWSDPYPYSKKMAEKAVLAANGSMLK 174
Query: 179 NDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLA 238
G L+TCA+RP IYG IIT K +L G + + V+V N+ A
Sbjct: 175 --IGGTLHTCALRPMFIYGERSPFISNTIITALKNKNILGCTGKFSTANP-VYVGNVAWA 231
Query: 239 LILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAVD 298
ILA+ GL D K+ P G+ Y+ISD +P +++ L L P +S ++
Sbjct: 232 HILAARGLRDP-----KKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEWGFCPDSSWSLP 286
Query: 299 HALV--LGRICQGVYTILYPWLDRWWLPQPFILPSEVHKV---GVTHYFSYLKAKEEIGY 353
L+ L + + V +L P FI P H V G T FSY KA+ ++GY
Sbjct: 287 VPLLYWLAFMLETVSFLLSPIYR-------FIPPFNRHLVTLTGSTFTFSYKKAQRDLGY 339
Query: 354 VPMVSSREGMASTISYW 370
P+VS E T S W
Sbjct: 340 EPLVSWEEAKQKT-SEW 355
>3BH1_MOUSE (P24815) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type I (3Beta-HSD I) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delt
Length = 372
Score = 113 bits (282), Expect = 1e-24
Identities = 111/371 (29%), Positives = 174/371 (45%), Gaps = 28/371 (7%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GFVG + LV+ + EVRA D + + V ++GD
Sbjct: 2 GWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETKEEFSKLQTKTKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + ++ + VN+ GT ++L+AC+ + +
Sbjct: 62 ILDAQCLRRACQGISVVIHTAAV-IDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAG 182
+CS+ +V + ++NG+E + DPY SK +AE+ VL N KN G
Sbjct: 121 FCSSVDVAGPNSYKKIVLNGHEEQNH--ESTWSDPYPYSKKMAEKAVLAANGSMLKN--G 176
Query: 183 NCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILA 242
L TCA+RP IYG II K +L G ++ + V+VEN+ A ILA
Sbjct: 177 GTLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSIANP-VYVENVAWAHILA 235
Query: 243 SMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL-PKTSLAVDHAL 301
+ GL D K+ GQ Y+ISD +P +++ L L S E+ L P S ++ L
Sbjct: 236 ARGLRDP-----KKSTSIQGQFYYISDDTPHQSYDDLNYTL-SKEWGLRPNASWSLPLPL 289
Query: 302 V--LGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSS 359
+ L + + V +L P + +P + T FSY KA+ ++GY P+V+
Sbjct: 290 LYWLAFLLETVSFLLRP----VYRYRPLFNRHLITLSNSTFTFSYKKAQRDLGYEPLVNW 345
Query: 360 REGMASTISYW 370
E T S W
Sbjct: 346 EEAKQKT-SEW 355
>3BH2_MOUSE (P26149) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type II (3Beta-HSD II) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid de
Length = 372
Score = 112 bits (279), Expect = 3e-24
Identities = 112/374 (29%), Positives = 170/374 (44%), Gaps = 34/374 (9%)
Query: 11 GKTLVVTGGLGFVGSALCLELVRR-GAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + LV+ E+R D +F + N V ++GD
Sbjct: 2 GWSCLVTGAKGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETRKEFFNLETSNKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + ++ + VN+ GT ++L+AC+ + +
Sbjct: 62 ILDTQYLRRACQGISVVIHTAAI-IDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAG 182
+ S+ +V + ++NG+E + DPY SK +AE+ VL N KN G
Sbjct: 121 FSSSVDVAGPNSYKEIVLNGHEEECHEST--WSDPYPYSKKMAEKAVLAANGSMLKN--G 176
Query: 183 NCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLALILA 242
L TCA+RP IYG II K +L + G + V+V N+ A ILA
Sbjct: 177 GTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKFNTANP-VYVGNVAWAHILA 235
Query: 243 SMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PKTSLAVDH 299
+ GL D K+ P G+ Y+ISD +P +F+ + L S E+ SL V
Sbjct: 236 ARGLRDP-----KKSPNIQGEFYYISDDTPHQSFDDISYTL-SKEWGFCLDSSWSLPVPL 289
Query: 300 ALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKV---GVTHYFSYLKAKEEIGYVPM 356
L + + V +L P +I P H V G T FSY KA+ ++GY P+
Sbjct: 290 LYWLAFLLETVSFLLSPIYR-------YIPPFNRHLVTLSGSTFTFSYKKAQRDLGYEPL 342
Query: 357 VSSREGMASTISYW 370
VS E T S W
Sbjct: 343 VSWEEAKQKT-SEW 355
>3BH1_MESAU (Q60555) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type I (3Beta-HSD I) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delt
Length = 372
Score = 111 bits (278), Expect = 4e-24
Identities = 117/378 (30%), Positives = 178/378 (46%), Gaps = 42/378 (11%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + LV+ + EVRA D + + V ++GD
Sbjct: 2 GWSCLVTGAGGFLGQRIIRMLVQEKELQEVRALDKVFRPETREEFCKLQTKTKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGI 121
I+ + + A +G V H AA FG ++ T +D +N+ GT ++L+AC+ +
Sbjct: 62 ILDAQCLRRACQGISVVIHTAAAIDVFGAIPRQ----TIID-INLKGTLNLLEACVQASV 116
Query: 122 KRLVYCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFK 178
+Y S+ +V + ++NG+E + DPY SK +AE+ VL N K
Sbjct: 117 PAFIYTSSIDVAGPNSYKEIVLNGHEEQQH--ESTWSDPYPYSKKMAEKAVLAANGSSLK 174
Query: 179 NDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAK-LGLLLFTIGDQTVKSDWVFVENLVL 237
N G L+TCA+RP IYG II K G+L T TV V+V N
Sbjct: 175 N--GGTLHTCALRPMYIYGEKSPLISVTIIRAVKNSGILDVTGKFSTVNP--VYVNNAAW 230
Query: 238 ALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAV 297
A ILA+ GL D ++ P GQ Y+ISD +P +++ L +L P +S
Sbjct: 231 AHILAARGLQDP-----RKSPNIQGQFYYISDDTPHQSYDDLNYVLSKDWGLRPDSSWRP 285
Query: 298 DHALV--LGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKAKEEIG 352
AL+ LG + + V +L P + QP P H V +++ FSY KA+ ++G
Sbjct: 286 PVALLYWLGFLLELVSFLLRPVYNY----QP---PFNRHLVTLSNTVFTFSYKKAQRDLG 338
Query: 353 YVPMVSSREGMASTISYW 370
Y P+V E +T S W
Sbjct: 339 YEPLVGWEEARENT-SEW 355
>3BH4_RAT (Q62878) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type IV (3Beta-HSD IV) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delt
Length = 372
Score = 110 bits (276), Expect = 6e-24
Identities = 114/376 (30%), Positives = 173/376 (45%), Gaps = 38/376 (10%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + LV+ + EVR D +F + V ++GD
Sbjct: 2 GWSCLVTGAGGFLGQRIVQLLVQEKDLKEVRVLDKVFRPETREEFFNLGTSIKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAF-GMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRL 124
I+ + + A +G V H AA ++G Q + VN+ GT ++L+AC+ +
Sbjct: 62 ILDTQCLRRACQGISVVIHTAALIDVTGVNPRQT--ILDVNLKGTQNLLEACVQASVPAF 119
Query: 125 VYCSTYNVVFAG---QRIVNGNESLPYFPIDHH----VDPYGRSKSIAEQLVLKNNARPF 177
+YCST +V + I+NG+E +HH +PY SK +AE+ VL N
Sbjct: 120 IYCSTVDVAGPNSYKKIILNGHEE------EHHESTWSNPYPYSKKMAEKAVLAANGSIL 173
Query: 178 KNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVL 237
KN G L+TCA+RP IYG I+ K +L G ++ + V+V N+
Sbjct: 174 KN--GGTLHTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKFSIANP-VYVGNVAW 230
Query: 238 ALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PKTS 294
A ILA+ GL D + Q GQ Y+ISD +P +++ L L S E+ L S
Sbjct: 231 AHILAARGLRDPKKSQNVQ-----GQFYYISDDTPHQSYDDLNYTL-SKEWGLHLDSSWS 284
Query: 295 LAVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYV 354
L + L + + V L+P + +P V FSY KA+ ++GY
Sbjct: 285 LPLPLLYWLAFLLEIVSFFLHPVYNY----RPSFNRHLVTLSNSKFTFSYKKAQRDLGYE 340
Query: 355 PMVSSREGMASTISYW 370
P+VS E T S W
Sbjct: 341 PLVSWEEAKQKT-SEW 355
>3BH2_MESAU (Q64421) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type II (3Beta-HSD II) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid de
Length = 372
Score = 110 bits (274), Expect = 1e-23
Identities = 111/371 (29%), Positives = 169/371 (44%), Gaps = 28/371 (7%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + LV+ + EVR D +F + V ++GD
Sbjct: 2 GWSCLVTGAGGFLGQRIIHLLVQEKDLEEVRLLDKVFRPETREEFFKLQTKTKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + ++ + +N+ GT ++L+AC+ + +
Sbjct: 62 ILDAQCLRRACQGISVVIHTAA-AIDVWGIIPRQTIIDINVKGTLNLLEACVQASVPAFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNARPFKNDAG 182
Y S+ +V + ++NG+E + DPY SK +AE+ VL N KN G
Sbjct: 121 YTSSIDVAGPNSYKEIVLNGHEEQQH--ESTWSDPYPYSKMMAEKAVLAANGSFLKN--G 176
Query: 183 NCLYTCAVRPAAIYGPGEDRHLPRIITTAK-LGLLLFTIGDQTVKSDWVFVENLVLALIL 241
L+TCA+RP IYG +I K G+L T TV V+V N A IL
Sbjct: 177 GTLHTCALRPMYIYGEKSSILSGIMIRAIKNNGILKVTGKFSTVNP--VYVSNAAWAHIL 234
Query: 242 ASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLAVDHAL 301
A+ GL D K+ P GQ Y+ISD +P +++ L L P +S AL
Sbjct: 235 AARGLQDP-----KKSPNIQGQFYYISDDTPHQSYDDLNNTLSKKWGLRPDSSWRPPVAL 289
Query: 302 V--LGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVPMVSS 359
+ LG + + V +L P + QP V FSY KA+ ++GY P+V
Sbjct: 290 LYWLGFLLELVNFLLRPVYNY----QPPFTRYLVTISNTVFTFSYKKAQRDLGYEPLVGW 345
Query: 360 REGMASTISYW 370
E +T S W
Sbjct: 346 EEARENT-SEW 355
>3BH3_MOUSE (P26150) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type III (3Beta-HSD III) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid
Length = 372
Score = 106 bits (265), Expect = 1e-22
Identities = 110/379 (29%), Positives = 171/379 (45%), Gaps = 44/379 (11%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFDL----RDSSPWFAILKDNGVRCIQGD 65
G + +VTG GF+G + LV+ + E+R D +F + V ++GD
Sbjct: 2 GWSCLVTGAGGFLGQRIIQLLVQEKDLEEIRVLDKVFKPETREQFFNLGTSIKVTVLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ + + A +G V H AA + ++ + VN+ GT ++L+AC+ + +
Sbjct: 62 ILDTQYLRRACQGISVVIHTAAI-IDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFI 120
Query: 126 YCSTYNVVFAGQR---IVNGNESLPYFPIDHH-----VDPYGRSKSIAEQLVLKNNARPF 177
+ S+ +V ++NG+E D H DPY SK +AE+ VL N
Sbjct: 121 FSSSVDVAGPNSYKDIVLNGHE-------DEHRESTWSDPYPYSKKMAEKAVLAANGSML 173
Query: 178 KNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVL 237
KN G L TCA+RP IYG + L I A + G + ++ V+V N+
Sbjct: 174 KN--GGTLQTCALRPMCIYGE-RSQFLSNTIIKALKNKFILRGGGKFSTANPVYVGNVAW 230
Query: 238 ALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTS--- 294
A ILA+ GL + K+ P G+ Y+ISD +P +++ L L S E+ S
Sbjct: 231 AHILAARGLRNP-----KKSPNIQGEFYYISDDTPHQSYDDLNYTL-SKEWGFCLNSRWY 284
Query: 295 LAVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVT---HYFSYLKAKEEI 351
L V L + + V +L P +I P H V +T FSY KA+ ++
Sbjct: 285 LPVPILYWLAFLLETVSFLLSPIYR-------YIPPFNRHLVTLTASTFTFSYKKAQRDL 337
Query: 352 GYVPMVSSREGMASTISYW 370
GY P+VS E T S W
Sbjct: 338 GYEPLVSWEEAKQKT-SEW 355
>3BHS_MACMU (P27365) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase (3Beta-HSD) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delta-isomera
Length = 372
Score = 103 bits (256), Expect = 1e-21
Identities = 112/380 (29%), Positives = 177/380 (46%), Gaps = 47/380 (12%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFD------LRDSSPWFAILKDNG-VRCI 62
G + +VTG GF+G + LV + E+R D LR+ F+ L++ + +
Sbjct: 2 GWSCLVTGAGGFLGQRIVRLLVEEKELKEIRVLDKAFRPELREE---FSKLQNKTKLTVL 58
Query: 63 QGDIVRKEDVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLH 118
+GDI+ + ++ A + V H A FG++ +E + VN+ GT +L+AC+
Sbjct: 59 EGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIM-----NVNVKGTQLLLEACVQ 113
Query: 119 LGIKRLVYCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNAR 175
+ +Y ST V + I NG+E P + PY SK +AE+ VL N
Sbjct: 114 ASVPVFIYTSTLEVAGPNSYKEIIQNGHEEEPLE--NTWPAPYPYSKKLAEKAVLAANGW 171
Query: 176 PFKNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENL 235
KN G LYTCA+RP IYG G I +L ++G + + V+V N+
Sbjct: 172 TLKN--GGTLYTCALRPMYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNP-VYVGNV 228
Query: 236 VLALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PK 292
A ILA L D K+ P GQ Y+ISD +P +++ L +L S E+ L +
Sbjct: 229 AWAHILALRALRDP-----KKAPSVQGQFYYISDDTPHQSYDNLNYIL-SKEFGLCLDSR 282
Query: 293 TSLAVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKAKE 349
SL + +G + + V +L P + QP P H V +++ FSY KA+
Sbjct: 283 WSLPLALMYWIGFLLEVVSFLLSP----VYSYQP---PFNRHTVTLSNSVFTFSYKKAQR 335
Query: 350 EIGYVPMVSSREGMASTISY 369
++ Y P+ S E T+ +
Sbjct: 336 DLAYKPLYSWEEAKQKTVEW 355
>3BH2_HUMAN (P26439) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type II (3Beta-HSD II) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid de
Length = 371
Score = 102 bits (253), Expect = 3e-21
Identities = 111/380 (29%), Positives = 178/380 (46%), Gaps = 47/380 (12%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFD------LRDSSPWFAILKDNG-VRCI 62
G + +VTG G +G + LV + E+RA D LR+ F+ L++ + +
Sbjct: 1 GWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREE---FSKLQNRTKLTVL 57
Query: 63 QGDIVRKEDVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLH 118
+GDI+ + ++ A + V H A FG++ +E + VN+ GT +L+AC+
Sbjct: 58 EGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIM-----NVNVKGTQLLLEACVQ 112
Query: 119 LGIKRLVYCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNAR 175
+ +Y S+ V + I NG+E P + PY SK +AE+ VL N
Sbjct: 113 ASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLE--NTWPTPYPYSKKLAEKAVLAANGW 170
Query: 176 PFKNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENL 235
KN G+ LYTCA+RP IYG G I +L ++G + + V+V N+
Sbjct: 171 NLKN--GDTLYTCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNP-VYVGNV 227
Query: 236 VLALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PK 292
A ILA L D K+ P GQ Y+ISD +P +++ L +L S E+ L +
Sbjct: 228 AWAHILALRALRDP-----KKAPSVRGQFYYISDDTPHQSYDNLNYIL-SKEFGLRLDSR 281
Query: 293 TSLAVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKAKE 349
SL + +G + + V +L P + QP P H V +++ FSY KA+
Sbjct: 282 WSLPLTLMYWIGFLLEVVSFLLSP----IYSYQP---PFNRHTVTLSNSVFTFSYKKAQR 334
Query: 350 EIGYVPMVSSREGMASTISY 369
++ Y P+ S E T+ +
Sbjct: 335 DLAYKPLYSWEEAKQKTVEW 354
>3BH1_HUMAN (P14060) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase type I (3Beta-HSD I) (Trophoblast
antigen FDO161G) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progest
Length = 372
Score = 98.2 bits (243), Expect = 4e-20
Identities = 112/382 (29%), Positives = 175/382 (45%), Gaps = 51/382 (13%)
Query: 11 GKTLVVTGGLGFVGSALCLELVR-RGAHEVRAFD------LRDSSPWFAILKDNG-VRCI 62
G + +VTG GF+G + LV+ + E+R D LR+ F+ L++ + +
Sbjct: 2 GWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREE---FSKLQNKTKLTVL 58
Query: 63 QGDIVRKEDVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLH 118
+GDI+ + ++ A + + H A FG++ +E + VN+ GT +L+AC+
Sbjct: 59 EGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIM-----NVNVKGTQLLLEACVQ 113
Query: 119 LGIKRLVYCSTYNVVFAG---QRIVNGNESLPYFPIDHHVDPYGRSKSIAEQLVLKNNAR 175
+ +Y S+ V + I NG+E P + PY SK +AE+ VL N
Sbjct: 114 ASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLE--NTWPAPYPHSKKLAEKAVLAANGW 171
Query: 176 PFKNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTA--KLGLLLFTIGDQTVKSDWVFVE 233
KN G LYTCA+RP IYG G R L I A G+L TV V+V
Sbjct: 172 NLKN--GGTLYTCALRPMYIYGEG-SRFLSASINEALNNNGILSSVGKFSTVNP--VYVG 226
Query: 234 NLVLALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL--- 290
N+ A ILA L D K+ P GQ Y+ISD +P +++ L L S E+ L
Sbjct: 227 NVAWAHILALRALQDP-----KKAPSIRGQFYYISDDTPHQSYDNLNYTL-SKEFGLRLD 280
Query: 291 PKTSLAVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTH---YFSYLKA 347
+ S + +G + + V +L P + P H V +++ FSY KA
Sbjct: 281 SRWSFPLSLMYWIGFLLEIVSFLLRP-------IYTYRPPFNRHIVTLSNSVFTFSYKKA 333
Query: 348 KEEIGYVPMVSSREGMASTISY 369
+ ++ Y P+ S E T+ +
Sbjct: 334 QRDLAYKPLYSWEEAKQKTVEW 355
>3BH3_MESAU (O35296) 3 beta-hydroxysteroid dehydrogenase type III
(3Beta-HSD III) (3-beta-hydroxy-delta(5)-steroid
dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene
steroid dehydrogenase) (Progesterone reductase)
Length = 372
Score = 96.3 bits (238), Expect = 2e-19
Identities = 111/376 (29%), Positives = 165/376 (43%), Gaps = 46/376 (12%)
Query: 15 VVTGGLGFVGSALCLELVR-RGAHEVR----AFDLRDSSPWFAILKDNGVRCIQGDIVRK 69
+VTG GF+G + L + + EVR +F + + V ++GDI+
Sbjct: 6 LVTGAGGFLGQRIIRMLAQEKELQEVRTLFRSFTPKHREELSKLQTKTKVTVLEGDILDA 65
Query: 70 EDVESALRGADCVFHLAA----FGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
+ + A +G V H AA FG ++ V +N+ GT H+LDAC+ + +
Sbjct: 66 QCLRRACQGISVVIHTAAAIDVFGAIPRQT-----VIDINLKGTQHLLDACIGARVPVFI 120
Query: 126 YCSTYNVVFAGQR-----IVNGNESLPYFPIDHH----VDPYGRSKSIAEQLVLKNNARP 176
Y S +V AG I NG+E ++H DPY SK +AE+ VL N
Sbjct: 121 YSS--SVAVAGPNSYKVIIQNGSEE------ENHESTWSDPYAYSKKMAEKAVLAANGST 172
Query: 177 FKNDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLV 236
K+ G L+TCA+R IYG + K L+ +V S V+V N
Sbjct: 173 LKD--GGTLHTCALRLPFIYGEKSKFISDTMDRALKNNGLINGFSRFSVISS-VYVNNAA 229
Query: 237 LALILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYELPKTSLA 296
A +LA+ GL D K+ P GQ Y+ISD +P +++ L L P +S
Sbjct: 230 WAHVLAARGLQDP-----KKSPNIQGQFYYISDDTPHQSYDDLCYTLSKDWGLRPDSSWK 284
Query: 297 VDHALV--LGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYV 354
AL+ G + + V +L P + QP V + FSY KA+ ++GY
Sbjct: 285 PPVALLYWFGFLLETVSFLLRPVYNY----QPPFNRHLVTLLNSVFTFSYKKAQRDLGYE 340
Query: 355 PMVSSREGMASTISYW 370
P+VS E T S W
Sbjct: 341 PLVSWEEAREKT-SEW 355
>3BHS_BOVIN (P14893) 3 beta-hydroxysteroid dehydrogenase/delta
5-->4-isomerase (3Beta-HSD) [Includes:
3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC
1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase)
(Progesterone reductase); Steroid delta-isomera
Length = 372
Score = 95.5 bits (236), Expect = 3e-19
Identities = 104/371 (28%), Positives = 166/371 (44%), Gaps = 35/371 (9%)
Query: 11 GKTLVVTGGLGFVGSAL-CLELVRRGAHEVRAFDL---RDSSPWFAILKDN-GVRCIQGD 65
G + +VTGG GF+G + CL + + E+R D + F+ L+ + ++GD
Sbjct: 2 GWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLEGD 61
Query: 66 IVRKEDVESALRGADCVFHLAAFGMSGKEMLQLTRVDQVNITGTCHVLDACLHLGIKRLV 125
I+ ++ ++ A +G V H A+ + + + + VN+ GT +L+AC+ + +
Sbjct: 62 ILDEQCLKGACQGTSVVIHTASV-IDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVFI 120
Query: 126 YCSTYNVVFAG---QRIVNGNESLPYFPIDHHVD----PYGRSKSIAEQLVLKNNARPFK 178
+ ST V + I +G E +HH PY SK +AE+ VL N K
Sbjct: 121 HTSTIEVAGPNSYREIIQDGREE------EHHESAWSSPYPYSKKLAEKAVLGANGWALK 174
Query: 179 NDAGNCLYTCAVRPAAIYGPGEDRHLPRIITTAKLGLLLFTIGDQTVKSDWVFVENLVLA 238
N G LYTCA+RP IYG G L + A + T + + + V+V N+ A
Sbjct: 175 N--GGTLYTCALRPMYIYGEGSP-FLSAYMHGALNNNGILTNHCKFSRVNPVYVGNVAWA 231
Query: 239 LILASMGLLDDSAGKGKQRPIAAGQAYFISDGSPVNTFEFLQPLLRSLEYEL---PKTSL 295
ILA L D K+ P GQ Y+ISD +P +++ L L S E+ + SL
Sbjct: 232 HILALRALRDP-----KKVPNIQGQFYYISDDTPHQSYDDLNYTL-SKEWGFCLDSRMSL 285
Query: 296 AVDHALVLGRICQGVYTILYPWLDRWWLPQPFILPSEVHKVGVTHYFSYLKAKEEIGYVP 355
+ L + + V +L P + P V FSY KA+ ++GY P
Sbjct: 286 PISLQYWLAFLLEIVSFLLSP----IYKYNPCFNRHLVTLSNSVFTFSYKKAQRDLGYEP 341
Query: 356 MVSSREGMAST 366
+ + E T
Sbjct: 342 LYTWEEAKQKT 352
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.326 0.142 0.447
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,567,058
Number of Sequences: 164201
Number of extensions: 2408758
Number of successful extensions: 6991
Number of sequences better than 10.0: 158
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 6744
Number of HSP's gapped (non-prelim): 175
length of query: 479
length of database: 59,974,054
effective HSP length: 114
effective length of query: 365
effective length of database: 41,255,140
effective search space: 15058126100
effective search space used: 15058126100
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 68 (30.8 bits)
Lotus: description of TM0335a.3