BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0316.5
         (318 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CNC0_HUMAN (Q8NEJ9) Protein C14orf120                                 130  6e-30
CNC0_MOUSE (Q9DB96) Protein C14orf120 homolog                         129  7e-30
YA36_SCHPO (Q09713) Hypothetical protein C18B11.06 in chromosome I     85  3e-16
TRHY_HUMAN (Q07283) Trichohyalin                                       49  2e-05
NUMA_HUMAN (Q14980) Nuclear mitotic apparatus protein 1 (NuMA pr...    45  3e-04
SNXN_HUMAN (Q96L93) Kinesin-like motor protein C20orf23 (Sorting...    41  0.003
RA50_AQUAE (O67124) Probable DNA double-strand break repair rad5...    41  0.003
RA50_SULAC (O33600) DNA double-strand break repair rad50 ATPase        41  0.005
MAPB_HUMAN (P46821) Microtubule-associated protein 1B (MAP 1B) [...    41  0.005
EEA1_HUMAN (Q15075) Early endosome antigen 1 (Endosome-associate...    41  0.005
TRHY_RABIT (P37709) Trichohyalin                                       40  0.008
REST_HUMAN (P30622) Restin (Cytoplasmic linker protein-170 alpha...    40  0.008
MYS2_DICDI (P08799) Myosin II heavy chain, non muscle                  40  0.008
GARP_PLAFF (P13816) Glutamic acid-rich protein precursor               40  0.008
YDOF_SCHPO (O13734) Hypothetical protein C15A10.15 in chromosome I     40  0.010
RA50_PYRHO (O58687) DNA double-strand break repair rad50 ATPase        40  0.010
IF2P_SCHPO (Q10251) Eukaryotic translation initiation factor 5B ...    40  0.010
KF3A_MOUSE (P28741) Kinesin-like protein KIF3A (Microtubule plus...    39  0.013
EEA1_MOUSE (Q8BL66) Early endosome antigen 1 (Fragment)                39  0.017
IF2_VIBVY (Q7MI09) Translation initiation factor IF-2                  39  0.022

>CNC0_HUMAN (Q8NEJ9) Protein C14orf120
          Length = 315

 Score =  130 bits (326), Expect = 6e-30
 Identities = 98/329 (29%), Positives = 152/329 (45%), Gaps = 48/329 (14%)

Query: 15  EKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQSL 74
           E +      LLK ++E +  V  +++SLT KV+ G YPT  G S+LE K+ LLL Y   L
Sbjct: 8   ESDLPSAVTLLKNLQEQVMAVTAQVKSLTQKVQAGAYPTEKGLSFLEVKDQLLLMYLMDL 67

Query: 75  VYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPS 134
            + +L KA G S++ H  V  +VEIR  LEK+RP+D+K +YQI KL+K     + S+   
Sbjct: 68  THLILDKASGGSLQGHDAVLRLVEIRTVLEKLRPLDQKLKYQIDKLIKTAVTGSLSE--- 124

Query: 135 KKEPVASDKSEDVSKYRPNPDMLVSR---EDLAPQEGHD----------------AYRPV 175
                      D  +++P+P  ++S+   ED    E  D                 Y P 
Sbjct: 125 ----------NDPLRFKPHPSNMMSKLSSEDEEEDEAEDDQSEASGKKSVKGVSKKYVPP 174

Query: 176 KFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEV 235
           +  P   D+ +  ++++   R ++  L     SS IR L     + PEEIRD       V
Sbjct: 175 RLVPVHYDETEAEREKKRLERAKRRALS----SSVIRELKEQYSDAPEEIRD--ARHPHV 228

Query: 236 ERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTESFFDEIKTLP---- 291
            R   + + R   EE +  R+ ++K E+ R K      + L  LT   F +I  L     
Sbjct: 229 TRQSQEDQHRINYEESMMVRLSVSKREKGRRKRANVMSSQLHSLTH--FSDISALTGGTV 286

Query: 292 --FEDET--GEQVMGPSKGSNRNGRLKKR 316
              ED+    ++   P KG  + G  ++R
Sbjct: 287 HLDEDQNPIKKRKKIPQKGRKKKGFRRRR 315


>CNC0_MOUSE (Q9DB96) Protein C14orf120 homolog
          Length = 315

 Score =  129 bits (325), Expect = 7e-30
 Identities = 96/323 (29%), Positives = 149/323 (45%), Gaps = 43/323 (13%)

Query: 15  EKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQSL 74
           E + S    LLK ++E +  V  +IQ+LT KV+ G Y T  G S+LE K+ LLL Y   L
Sbjct: 8   ESDVSSSITLLKNLQEQVMAVTAQIQALTTKVRAGTYSTEKGLSFLEVKDQLLLMYLMDL 67

Query: 75  VYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPS 134
            + +L KA G S++ HP V  +VEIR  LEK+RP+D+K +YQI KL+K     + S+   
Sbjct: 68  SHLILDKASGASLQGHPAVLRLVEIRTVLEKLRPLDQKLKYQIDKLVKTAVTGSLSE--- 124

Query: 135 KKEPVASDKSEDVSKYRPNPDMLVSR------EDLAPQEGHD-------------AYRPV 175
                      D  +++P+P  +VS+      E+   +EG                Y P 
Sbjct: 125 ----------NDPLRFKPHPSNMVSKLSSEDEEESEAEEGQSEASGKKSAKGSAKKYVPP 174

Query: 176 KFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEV 235
           +  P   D+ +  ++++   + ++  L     SS IR L     + PEEIRD       V
Sbjct: 175 RLVPVHYDETEAEREQKRLEKAKRRALS----SSVIRELKEQYSDAPEEIRD--ARHPHV 228

Query: 236 ERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTESFFDEIKTLPFEDE 295
            R   + + R   EE +  R+ ++K E+   +      + L  LT   F +I  L     
Sbjct: 229 TRQSQEDQHRVNYEESMMVRLSVSKREKGLRRRASAMSSQLHSLTH--FSDISALTGGTA 286

Query: 296 TGEQVMGPSKGSN---RNGRLKK 315
             ++   P K      + GR KK
Sbjct: 287 HLDEDQNPVKKRKKLPKKGRKKK 309


>YA36_SCHPO (Q09713) Hypothetical protein C18B11.06 in chromosome I
          Length = 327

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 73/268 (27%), Positives = 128/268 (47%), Gaps = 26/268 (9%)

Query: 32  LDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQSLVYYLLRKAKGFSIEEHP 91
           +DV+   IQ+    + +    ++DG S +  K  LLL+Y Q L + +L K    S  +H 
Sbjct: 1   MDVLNKSIQTALEALPKTSSSSSDGVSLVSLKCQLLLSYVQKLAFLMLVKLDDESFLQHQ 60

Query: 92  -VVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPV--ASDK-SEDV 147
            VV  +V++R+ +EKIRP++ + QY + KL++        ++ S KEP    +DK S+D 
Sbjct: 61  DVVEKLVQLRIEIEKIRPLENRIQYSVDKLLRAA--GRKEEIGSIKEPENNGNDKDSQDS 118

Query: 148 SK--YRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEIL--- 202
            K  Y+PN        D    E +      K + +S D+++  +  ++ + R   I    
Sbjct: 119 LKLHYKPNLSEFADDSDGPASENNVVKEDDKSSISSEDEEEELRSAKDGIYRPPRIRAVT 178

Query: 203 ----KESKH------SSFIRTLMNDI-EEKPEEIRDYEGSSKEV---ERHIAKMEERAWQ 248
               K ++H        F+ + M+ + +  P    + E   + +   ER + KM ER   
Sbjct: 179 MDSEKRTRHRPNHLVDEFVSSDMSSVPQSMPSVGSNLEKRGRVIHADERELQKMRERIEY 238

Query: 249 EEELFNRVP-LTKHERKREKYLKKSRNG 275
           EE  + R+P L+K + K+ K +KK   G
Sbjct: 239 EESNYTRLPKLSKKDLKKSKRVKKHDYG 266


>TRHY_HUMAN (Q07283) Trichohyalin
          Length = 1898

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 38/171 (22%), Positives = 79/171 (45%), Gaps = 10/171 (5%)

Query: 104  EKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDL 163
            EK R  ++++QY+  K ++  E     + P K+      + E   KYR   ++    E L
Sbjct: 966  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR-----RQEREKKYREEEELQQEEEQL 1020

Query: 164  APQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPE 223
              +E  +  R  ++      +D+  ++E   LR E+E  +  +     R    +++++ E
Sbjct: 1021 LREE-REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQEEE 1078

Query: 224  EIRDYEGSSK---EVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKK 271
            ++   E  ++   E+ER   K EE   +EE+L    P  +  ++RE+  ++
Sbjct: 1079 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE 1129



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 37/207 (17%), Positives = 85/207 (40%), Gaps = 17/207 (8%)

Query: 79  LRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEP 138
           L+  KG   EE P    +    L   + +  ++KQQ + ++  +V +     +   K+E 
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW-RKRET 251

Query: 139 VASDKSEDVSKYRPNPDMLVSRED------------LAPQEGHDAYRPVKFAPTSMDQDK 186
           V   + E + +  P     +  E+               QE     + ++       + +
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311

Query: 187 TSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERA 246
             ++E+   RRE++  +E +     + L  + EE+ E+    E   +  E+ + + +E  
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371

Query: 247 WQEEELFNRVPLTKHERKREKYLKKSR 273
            +E++L       + E +RE+ L++ +
Sbjct: 372 RREQQLRRE----QEEERREQQLRREQ 394



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 25/122 (20%), Positives = 50/122 (40%), Gaps = 12/122 (9%)

Query: 161  EDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMND--- 217
            + L  QE    +R  +      ++ +   QE +   RE+E L++ +    +R    D   
Sbjct: 1717 QQLRRQERDRKFREEEQLRQGREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY 1776

Query: 218  --------IEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYL 269
                    +EE+ + +R         E   A  E+   +E+EL+      K  ++RE+ L
Sbjct: 1777 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEE-QKRRQERERKL 1835

Query: 270  KK 271
            ++
Sbjct: 1836 RE 1837



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 30/144 (20%), Positives = 63/144 (42%), Gaps = 17/144 (11%)

Query: 160  REDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIE 219
            +E L  QE +      +      ++ +  +QER+   RE+E L++ +    +R+     +
Sbjct: 1692 QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQGREEQQLRS-----Q 1746

Query: 220  EKPEEIRDYEGSSKEVERHIAKMEER----AWQEEELFNRVPLTKHERKREKYLKKSRNG 275
            E   + R+ E   +E E    + ++R     W+EE+L           ++E+ L++ R+ 
Sbjct: 1747 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL--------QLEEQEQRLRQERDR 1798

Query: 276  LDGLTESFFDEIKTLPFEDETGEQ 299
                 E F  + K+   E E  ++
Sbjct: 1799 QYRAEEQFATQEKSRREEQELWQE 1822


>NUMA_HUMAN (Q14980) Nuclear mitotic apparatus protein 1 (NuMA
           protein) (SP-H antigen)
          Length = 2115

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 62/271 (22%), Positives = 122/271 (44%), Gaps = 35/271 (12%)

Query: 13  SKEKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQ 72
           +KEK+A  LA  L++ ++    +RH+++ L++ +K+ +    +     EA      ++ Q
Sbjct: 528 AKEKQAQ-LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ---DHAQ 583

Query: 73  SLVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDL 132
            L      + +  S+ E       +E  L  EK   ++  QQ Q+Q   +  ++A TS  
Sbjct: 584 QLA--TAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQ-QLQVANEARDSAQTSVT 639

Query: 133 PSKKEPVA-SDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQE 191
            +++E    S K E+          L +  + A QE H+A   V      +  ++    E
Sbjct: 640 QAQREKAELSRKVEE----------LQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689

Query: 192 RNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIA---KMEERAWQ 248
           +  + +EK+ L+E             ++   E ++  +GS +E +R  A   + ++R   
Sbjct: 690 KERVAQEKDQLQE------------QLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737

Query: 249 EEELFNRVPLTKHERKREKYLKKSRNGLDGL 279
           E +   R  + +H+R+R K L++ R G  GL
Sbjct: 738 ELKAETRSLVEQHKRER-KELEEERAGRKGL 767



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 54/259 (20%), Positives = 102/259 (38%), Gaps = 47/259 (18%)

Query: 1    MAETVNH-LNNHDSKEKEASPL----AALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTAD 55
            + E + H L   + K++E + L    AA +KE++E    V+   + L  K KE  + +  
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE--HASGS 1105

Query: 56   GFSYLEAKNLLLLNYCQSLVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQY 115
            G               QS       +A G      P    +  +R  + K+    +KQQ 
Sbjct: 1106 G--------------AQS-------EAAG---RTEPTGPKLEALRAEVSKLEQQCQKQQE 1141

Query: 116  QIQKLMKV--GENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSRE-DLAPQEGHDAY 172
            Q   L +    E A+ ++  S  E +     E   +   +   L S + +LA        
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA------- 1194

Query: 173  RPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSS 232
                F     D  K   + +  + R ++  +  + +S I +L  ++     ++ + EG S
Sbjct: 1195 ----FRTKVQDHSKAEDEWKAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGES 1248

Query: 233  KEVERHIAKMEERAWQEEE 251
            KE++R +    E++ + EE
Sbjct: 1249 KELKRLVMAESEKSQKLEE 1267


>SNXN_HUMAN (Q96L93) Kinesin-like motor protein C20orf23 (Sorting
            nexin 23)
          Length = 1317

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 48/206 (23%), Positives = 88/206 (42%), Gaps = 25/206 (12%)

Query: 87   IEEHPV-VRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPV----AS 141
            +E+H   V  + E+    EKI+P++ + QY+ ++L  + +N   + L  K+         
Sbjct: 875  LEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRG 934

Query: 142  DKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEI 201
              S D + Y+   +M    E LA  +  +A +  K   T       ++QE    ++EKEI
Sbjct: 935  PLSLDNTLYQVEKEMEEKEEQLAQYQA-NANQLQKLQATFEFTANIARQEEKVRKKEKEI 993

Query: 202  LK-----------------ESKHSSFIR--TLMNDIEEKPEEIRDYEGSSKEVERHIAKM 242
            L+                 E +HS+  R  TL  +IEE+ +++      S+E     A +
Sbjct: 994  LESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASL 1053

Query: 243  EERAWQEEELFNRVPLTKHERKREKY 268
            E      E+   R+     + K++ Y
Sbjct: 1054 EAEQEALEKDQERLEYEIQQLKQKIY 1079


>RA50_AQUAE (O67124) Probable DNA double-strand break repair rad50
           ATPase
          Length = 978

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 47/223 (21%), Positives = 104/223 (46%), Gaps = 17/223 (7%)

Query: 79  LRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEP 138
           L+KA+    E+  + R + ++   L+++  ++K+ +   +KL    + A    +  + E 
Sbjct: 230 LKKAE----EKDSLERELSQVVTKLKELENLEKEVEKLREKLEFSRKVAPYVPIAKRIEE 285

Query: 139 VASDKSE-DVSKYRPNPDMLVSREDL--APQEGHDAYRPVKFAPTSMDQDKTSKQERNAL 195
           +    +E  V K +   ++ V +++L  A +E +      +      +++K  +     L
Sbjct: 286 IDKKLTELKVRKNKLTKELAVLKDELSFAQEELNRIEAEKEKFKEEKEREKELEHRLKKL 345

Query: 196 RREKEILKE-SKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFN 254
           +  KEILKE S+ SS ++    + E+  +E  D     ++ ++ +A+ EE+  + +ELF+
Sbjct: 346 QEIKEILKELSQLSSSLKEKEREYEQAKQEFEDLSERVEKGKKLVAETEEKLEKIKELFS 405

Query: 255 RVPLTKHERKRE---------KYLKKSRNGLDGLTESFFDEIK 288
               T  + K           K LK+    L+ LT+ + ++ K
Sbjct: 406 EEEYTSLKMKERLLVELQRKLKELKEKEGQLENLTQKYKEKKK 448



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 29/95 (30%), Positives = 52/95 (54%), Gaps = 7/95 (7%)

Query: 186 KTSKQERNALRREKEILKE---SKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKM 242
           K  + +R AL++E E+LK+   +K     +TL N +EE+ +E+++ E   +++ + + K 
Sbjct: 178 KNLEGKREALKKEYELLKDYTPTKKEVLEKTLKN-LEEELKELKETE---EKLRQELKKA 233

Query: 243 EERAWQEEELFNRVPLTKHERKREKYLKKSRNGLD 277
           EE+   E EL   V   K     EK ++K R  L+
Sbjct: 234 EEKDSLERELSQVVTKLKELENLEKEVEKLREKLE 268



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 39/183 (21%), Positives = 85/183 (46%), Gaps = 20/183 (10%)

Query: 104 EKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRP----NPDMLVS 159
           E+++ + + ++   Q+L K  E          K+ +  + S+ V+K +       ++   
Sbjct: 214 EELKELKETEEKLRQELKKAEE----------KDSLERELSQVVTKLKELENLEKEVEKL 263

Query: 160 REDLAPQEGHDAYRPVKFAPTSMDQDKTS-KQERNALRREKEILKESKHSSFIRTLMNDI 218
           RE L        Y P+      +D+  T  K  +N L +E  +LK+    SF +  +N I
Sbjct: 264 REKLEFSRKVAPYVPIAKRIEEIDKKLTELKVRKNKLTKELAVLKDEL--SFAQEELNRI 321

Query: 219 EEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDG 278
           E + E+ ++ +   KE+E  + K++E    +E L     L+   +++E+  ++++   + 
Sbjct: 322 EAEKEKFKEEKEREKELEHRLKKLQE---IKEILKELSQLSSSLKEKEREYEQAKQEFED 378

Query: 279 LTE 281
           L+E
Sbjct: 379 LSE 381


>RA50_SULAC (O33600) DNA double-strand break repair rad50 ATPase
          Length = 886

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 67/312 (21%), Positives = 134/312 (42%), Gaps = 49/312 (15%)

Query: 37  HKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQSLVYYLLRKAKGFSIEEHPVVRSI 96
           HKI   T  + +G   +         K LL +N  +     +LR++ G     H +++ +
Sbjct: 126 HKILMSTTIIGQGSVESVFSDFPEVMKELLKINKLE-----MLRESNG---PIHSLIKVL 177

Query: 97  VEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKY------ 150
            +    L+ I+ I K+++ +I +L K  E         ++E  A +K +++++Y      
Sbjct: 178 TDRIRSLQSIKDILKREEAEIDRLKKEIEEIKVKLENIERE--AKEKEDELNQYNTEFNR 235

Query: 151 ----RPNPDMLVSR--------EDLAP-----QEGHDAYRPVKFAPTSMDQDKTSKQERN 193
               +   D+L           E++A      +E    Y  ++     +D+++   ++ N
Sbjct: 236 IKEIKVQYDILSGELSVVNKKIEEIALRLKDFEEKEKRYNKIETEVKELDENR---EKIN 292

Query: 194 ALRREKEILKE-SKHSSFIRTLMNDIEEKPE------EIRDYEGSSKEVERHIAKMEERA 246
            +   K IL +     S I  + ND++ K E      E+ + E   +E+E+   ++EE+ 
Sbjct: 293 TISSFKSILVQIDSLKSQINVVENDLKRKKEKLKRKKELEEKEKQYEEIEKRKKELEEKE 352

Query: 247 WQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTESFFDEIKTLPFEDETGEQVMGPSKG 306
            Q EE+  R+       +R+K   +  N +D  T+   ++IK +    +   Q+    KG
Sbjct: 353 KQYEEIEKRLTYVLKNIERQKNEIEKLNYVD--TQDLENKIKDV---SDRINQIDNELKG 407

Query: 307 -SNRNGRLKKRK 317
             +R G L  RK
Sbjct: 408 LLDRRGDLNGRK 419


>MAPB_HUMAN (P46821) Microtubule-associated protein 1B (MAP 1B)
           [Contains: MAP1 light chain LC1]
          Length = 2468

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 43/195 (22%), Positives = 87/195 (44%), Gaps = 13/195 (6%)

Query: 86  SIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATS----DLPSKKEPVAS 141
           S EE P V  +  +    EK   ++ K++  ++K   V      S    ++PSK+EP + 
Sbjct: 561 SKEETPEVTKVNHV----EKPPKVESKEKVMVKKDKPVKTETKPSVTEKEVPSKEEP-SP 615

Query: 142 DKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEI 201
            K+E   K   +     ++E    +E        K       ++   K+++  +++E++ 
Sbjct: 616 VKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP 675

Query: 202 LKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKH 261
            KE       + +  + +++P++    E   KEV++ + K E++  ++EE   + P  K 
Sbjct: 676 KKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE---KEP-KKE 731

Query: 262 ERKREKYLKKSRNGL 276
            +K  K  KKS   L
Sbjct: 732 IKKLPKDAKKSSTPL 746


>EEA1_HUMAN (Q15075) Early endosome antigen 1 (Endosome-associated
           protein p162) (Zinc finger FYVE domain containing
           protein 2)
          Length = 1411

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 53/230 (23%), Positives = 100/230 (43%), Gaps = 14/230 (6%)

Query: 14  KEKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQS 73
           K+++   L ALL++ KE + ++  + + L AK++ G+  TA   + L+ KN  L    Q 
Sbjct: 521 KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA-VLNQLQEKNHTL----QE 575

Query: 74  LVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLP 133
            V  L  K K  S E H   +  +  ++  +K     +  Q ++  L +   N   S L 
Sbjct: 576 QVTQLTEKLKNQS-ESHKQAQENLHDQVQEQKAHL--RAAQDRVLSL-ETSVNELNSQLN 631

Query: 134 SKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERN 193
             KE V    S+   + +   ++L+S E     +  D    +  A  ++ QDK  +  + 
Sbjct: 632 ESKEKV----SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL-QDKQQELNKI 686

Query: 194 ALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKME 243
             + ++   K          L + ++E  E+    E  ++E+E  I K+E
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736


>TRHY_RABIT (P37709) Trichohyalin
          Length = 1407

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 33/162 (20%), Positives = 72/162 (44%), Gaps = 8/162 (4%)

Query: 110  DKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGH 169
            +++QQ + ++  K  E      L  ++E     + E   K R    +L   E L  QE  
Sbjct: 1087 EREQQLRRERDRKFREE---EQLLQEREEERLRRQERARKLREEEQLLRREEQLLRQERD 1143

Query: 170  DAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYE 229
              +R  +      ++++  +QER    RE+E L + +    +R      +E+  ++R+ E
Sbjct: 1144 RKFREEEQLLQESEEERLRRQERERKLREEEQLLQEREEERLRR-----QERARKLREEE 1198

Query: 230  GSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKK 271
               ++ E+ + +   R  +EEE   R    +  ++R++  ++
Sbjct: 1199 QLLRQEEQELRQERARKLREEEQLLRQEEQELRQERDRKFRE 1240



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 37/171 (21%), Positives = 74/171 (42%), Gaps = 5/171 (2%)

Query: 104 EKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSRED- 162
           E++R  +++QQ + ++  K  E      L  ++E     + E   K R    +L  RE+ 
Sbjct: 755 ERLRRQEREQQLRRERDRKFREE---EQLLQEREEERLRRQERERKLREEEQLLQEREEE 811

Query: 163 -LAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEK 221
            L  QE     R  +      ++++  +QER    RE+E L   +     +     + E+
Sbjct: 812 RLRRQERERKLREEEQLLQEREEERLRRQERERKLREEEQLLRQEEQELRQERARKLREE 871

Query: 222 PEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKS 272
            + +R  E   ++      + EE+  ++EE   R    +  R+ E+ L++S
Sbjct: 872 EQLLRQEEQELRQERDRKLREEEQLLRQEEQELRQERDRKLREEEQLLQES 922



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 19/88 (21%), Positives = 46/88 (51%), Gaps = 3/88 (3%)

Query: 182 MDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAK 241
           ++Q++  +Q+   LRRE+ + +E +    +R  + +I E+ + +   E   + +E+   +
Sbjct: 273 LEQEERREQQ---LRREQRLEQEERREQQLRRELEEIREREQRLEQEERREQRLEQEERR 329

Query: 242 MEERAWQEEELFNRVPLTKHERKREKYL 269
            ++   + EE+  R    + E +RE+ L
Sbjct: 330 EQQLKRELEEIREREQRLEQEERREQLL 357



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 31/174 (17%), Positives = 79/174 (44%), Gaps = 11/174 (6%)

Query: 100  RLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVS 159
            R + E+ + + ++++ ++++  +  +      L  ++E +   + E   K+R    +L  
Sbjct: 1098 RKFREEEQLLQEREEERLRRQERARKLREEEQLLRREEQLL--RQERDRKFREEEQLLQE 1155

Query: 160  RED--LAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMND 217
             E+  L  QE     R  +      ++++  +QER    RE+E L   +           
Sbjct: 1156 SEEERLRRQERERKLREEEQLLQEREEERLRRQERARKLREEEQLLRQEEQEL------- 1208

Query: 218  IEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKK 271
             +E+  ++R+ E   ++ E+ + +  +R ++EEE   R    +  R+R++  ++
Sbjct: 1209 RQERARKLREEEQLLRQEEQELRQERDRKFREEEQLLRREEQELRRERDRKFRE 1262



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 36/181 (19%), Positives = 75/181 (40%), Gaps = 6/181 (3%)

Query: 100 RLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVS 159
           R + E+ + + ++++ ++++  +  +      L  ++E     + E   K R    +L  
Sbjct: 772 RKFREEEQLLQEREEERLRRQERERKLREEEQLLQEREEERLRRQERERKLREEEQLLQE 831

Query: 160 RED--LAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMND 217
           RE+  L  QE     R  +      +Q+   +QER    RE+E L   +     +     
Sbjct: 832 REEERLRRQERERKLREEEQLLRQEEQEL--RQERARKLREEEQLLRQEEQELRQERDRK 889

Query: 218 IEEKPEEIRDYEGSSKEVERHIAKMEERAWQ--EEELFNRVPLTKHERKREKYLKKSRNG 275
           + E+ + +R  E   ++      + EE+  Q  EEE   R    +  R+ E+ L++    
Sbjct: 890 LREEEQLLRQEEQELRQERDRKLREEEQLLQESEEERLRRQERERKLREEEQLLRREEQE 949

Query: 276 L 276
           L
Sbjct: 950 L 950



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 42/180 (23%), Positives = 78/180 (43%), Gaps = 22/180 (12%)

Query: 143  KSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKE-- 200
            + E   K+R    +L   E    +E    +R  +      ++++  +QER    RE+E  
Sbjct: 1231 RQERDRKFREEEQLLRREEQELRRERDRKFREEEQLLQEREEERLRRQERARKLREEEEQ 1290

Query: 201  ILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTK 260
            +L E +    +R    D   + EE    E  S+ +ER + + EE+  + E          
Sbjct: 1291 LLFEEQEEQRLRQ-ERDRRYRAEEQFAREEKSRRLERELRQEEEQRRRRE---------- 1339

Query: 261  HERK-REKYLKKSRNGLDGLTESFFDEIKTLPF-EDETGEQVMGPSKGSNRNGRLKKRKA 318
             ERK RE+ L++ +       E    +++   F ED++  QV+ P  G+ +  R+  R +
Sbjct: 1340 RERKFREEQLRRQQE-----EEQRRRQLRERQFREDQSRRQVLEP--GTRQFARVPVRSS 1392



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 29/134 (21%), Positives = 54/134 (39%), Gaps = 10/134 (7%)

Query: 143  KSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEIL 202
            + E   K R    +L   E    QE     R  +      ++++  +QER    RE+E L
Sbjct: 883  RQERDRKLREEEQLLRQEEQELRQERDRKLREEEQLLQESEEERLRRQERERKLREEEQL 942

Query: 203  KESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERA---WQEEELFNRVPLT 259
               +     R       E+  ++R+ E   +E E    + +ERA    +EE+L  R    
Sbjct: 943  LRREEQELRR-------ERARKLREEEQLLQEREEERLRRQERARKLREEEQLLRREEQE 995

Query: 260  KHERKREKYLKKSR 273
              + +  K+ ++ +
Sbjct: 996  LRQERDRKFREEEQ 1009



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 18/82 (21%), Positives = 38/82 (45%)

Query: 190 QERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERAWQE 249
           +E+  LRRE E ++E +              + + +   E   +++ R + ++ ER  + 
Sbjct: 254 REQQQLRRELEEIREREQRLEQEERREQQLRREQRLEQEERREQQLRRELEEIREREQRL 313

Query: 250 EELFNRVPLTKHERKREKYLKK 271
           E+   R    + E +RE+ LK+
Sbjct: 314 EQEERREQRLEQEERREQQLKR 335



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 41/190 (21%), Positives = 82/190 (42%), Gaps = 18/190 (9%)

Query: 88   EEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDV 147
            EE  + R   E +L  E+     ++Q+ + ++  K+ E      L  ++E     + E  
Sbjct: 923  EEERLRRQERERKLREEEQLLRREEQELRRERARKLREE---EQLLQEREEERLRRQERA 979

Query: 148  SKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKH 207
             K R    +L   E    QE    +R  +      ++++  +QER+   RE+E  ++ + 
Sbjct: 980  RKLREEEQLLRREEQELRQERDRKFREEEQLLQEREEERLRRQERDRKFREEE--RQLRR 1037

Query: 208  SSFIRTLMNDIEEK---PEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERK 264
                     + + K    E+IR  E   K++ R   +  +R ++EEE   R       ++
Sbjct: 1038 QELEEQFRQERDRKFRLEEQIRQ-EKEEKQLRR---QERDRKFREEEQQRR------RQE 1087

Query: 265  REKYLKKSRN 274
            RE+ L++ R+
Sbjct: 1088 REQQLRRERD 1097


>REST_HUMAN (P30622) Restin (Cytoplasmic linker protein-170 alpha-2)
            (CLIP-170) (Reed-Sternberg intermediate filament
            associated protein)
          Length = 1427

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 54/294 (18%), Positives = 127/294 (42%), Gaps = 21/294 (7%)

Query: 4    TVNHLNNHDSKEKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAK 63
            T   L + D+  K +S   + +K++++ L+    +I+ L  +        +     L+ +
Sbjct: 758  TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817

Query: 64   NLLLLNYCQSLVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKV 123
             L L N  ++L    + + K    +E  +++   +     E+   + +  Q  + KL + 
Sbjct: 818  ELKLTNLQENLSE--VSQVKETLEKELQILKE--KFAEASEEAVSVQRSMQETVNKLHQK 873

Query: 124  GE--NAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTS 181
             E  N  +SDL   +E +A  +++   K      ++ ++E L     +D    +K +  +
Sbjct: 874  EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE----NDIAEIMKMSGDN 929

Query: 182  MDQ-----DKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEE-----IRDYEGS 231
              Q     D+   +ER+    + ++ K ++++SF++  + D+  K E+      + +E  
Sbjct: 930  SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 989

Query: 232  SKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTESFFD 285
             KE+ER ++ +E++          +   ++ER   +   K    L  L ++  D
Sbjct: 990  KKELERKLSDLEKKMETSHNQCQELK-ARYERATSETKTKHEEILQNLQKTLLD 1042


>MYS2_DICDI (P08799) Myosin II heavy chain, non muscle
          Length = 2116

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 35/138 (25%), Positives = 67/138 (48%), Gaps = 7/138 (5%)

Query: 184  QDKTSKQERNALRREKEILKESKHSSFIRT--LMNDIEEKPEEIRDYEGSSKEVERHIAK 241
            Q K  K+   A+   K+ L+  K    IR   + ++++EK   + + +   + VE  +  
Sbjct: 871  QLKAEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRD 930

Query: 242  MEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTE--SFFDEIKTLPFEDETGEQ 299
            +EE   +E++L N   L K ++K E+ L++ +   DG ++  S  ++IK    + E  E 
Sbjct: 931  LEEELQEEQKLRN--TLEKLKKKYEEELEEMKRVNDGQSDTISRLEKIKD-ELQKEVEEL 987

Query: 300  VMGPSKGSNRNGRLKKRK 317
                S+ S   G L+K +
Sbjct: 988  TESFSEESKDKGVLEKTR 1005



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 58/315 (18%), Positives = 133/315 (41%), Gaps = 29/315 (9%)

Query: 10   NHDSKEKEASPLAALLKEMKEGLDVV---RHKIQSLTAKVKEGQYPTADGFSYLEAKNLL 66
            N D+ EK+   L A+L+EMK+ L+     +  +  L  K +       +  S L++  + 
Sbjct: 1109 NRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQS-TIA 1167

Query: 67   LLNYCQSLVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGEN 126
             L   +S +   + + +G  +E   + +S VE +    ++   DK  Q          E 
Sbjct: 1168 KLEKIKSTLEGEVARLQG-ELEAEQLAKSNVEKQKKKVELDLEDKSAQL-------AEET 1219

Query: 127  AATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDK 186
            AA   L   K+ +  + SE  ++     +  V+       +  + +    F    ++ + 
Sbjct: 1220 AAKQALDKLKKKLEQELSEVQTQLSEANNKNVN------SDSTNKHLETSFNNLKLELEA 1273

Query: 187  TSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERA 246
              K ++   ++   +  E KH      +   +EE+ ++    E    ++E+ +++++++ 
Sbjct: 1274 EQKAKQALEKKRLGLESELKH------VNEQLEEEKKQKESNEKRKVDLEKEVSELKDQI 1327

Query: 247  WQEEELFNRVPLTKHERKREKYL---KKSRNGLDGLTESFFDEIKTLPFEDETGEQVMGP 303
              EEE+ ++  +T+ + K+E  L   K+    +    +   +++KTL  ++E        
Sbjct: 1328 --EEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAEE 1385

Query: 304  SKGSNRNGRLKKRKA 318
            ++G        K+KA
Sbjct: 1386 AEGQLDRAERSKKKA 1400



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 55/280 (19%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 5    VNHLNNHDSKEKEASPLAA--LLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEA 62
            VN     + K+KE++      L KE+ E  D +  ++ S  A V E +         ++ 
Sbjct: 1295 VNEQLEEEKKQKESNEKRKVDLEKEVSELKDQIEEEVASKKA-VTEAKNKKESELDEIKR 1353

Query: 63   KNLLLLNYCQSLVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMK 122
            +   +++     V  L    K    +   +  +  E    L++     KK ++ +++ +K
Sbjct: 1354 QYADVVSSRDKSVEQL----KTLQAKNEELRNTAEEAEGQLDRAERSKKKAEFDLEEAVK 1409

Query: 123  VGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSM 182
              E      + ++K   A  K+E  + YR     L   ++++ ++    Y  +K     +
Sbjct: 1410 NLEEETAKKVKAEK---AMKKAE--TDYRSTKSELDDAKNVSSEQ----YVQIKRLNEEL 1460

Query: 183  DQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKM 242
             + ++  +E +  R    I  +    S + +L ++I+         E  SKE+E  +A++
Sbjct: 1461 SELRSVLEEADE-RCNSAIKAKKTAESALESLKDEIDAANNAKAKAERKSKELEVRVAEL 1519

Query: 243  EERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTES 282
            EE    +    N     +  RK++  +   R  LD  TES
Sbjct: 1520 EESLEDKSGTVN----VEFIRKKDAEIDDLRARLDRETES 1555


>GARP_PLAFF (P13816) Glutamic acid-rich protein precursor
          Length = 678

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 41/200 (20%), Positives = 86/200 (42%), Gaps = 10/200 (5%)

Query: 111 KKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHD 170
           KK+  ++  L K G++   +     +E +  +   +++       +L S      Q G  
Sbjct: 164 KKENSEVMSLYKTGQHKPKNATEHGEENLDEEMVSEINNNAQGGLLLSSPYQYREQGGCG 223

Query: 171 AYRPV-KFAPTSMDQDKTS-KQERNALRREKEILK-----ESKHSSFIRTLMNDIEEKPE 223
               V + +  + D DK +  +++    +++E+LK     E K           IE+K +
Sbjct: 224 IISSVHETSNDTKDNDKENISEDKKEDHQQEEMLKTLDKKERKQKEKEMKEQEKIEKKKK 283

Query: 224 EIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLDGLTESF 283
           +  + E   +E ER   + +ER  +E+E+  +  + K  +K+E+  KK +       E+ 
Sbjct: 284 KQEEKEKKKQEKERKKQEKKERKQKEKEMKKQKKIEKERKKKEEKEKKKKKHDKENEETM 343

Query: 284 FDEIKTLPFEDETGEQVMGP 303
               +T    +ET  ++M P
Sbjct: 344 QQPDQT---SEETNNEIMVP 360



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 22/94 (23%), Positives = 42/94 (44%), Gaps = 3/94 (3%)

Query: 158 VSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMND 217
           + R ++ P+  +   +  K     + + K   +E +     KE+ +ESK    ++    +
Sbjct: 515 IGRVNVVPRRDNHKKKMAKIEEAELQKQKHVDKEEDKKEESKEVQEESKE---VQEDEEE 571

Query: 218 IEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEE 251
           +EE  EE  + E   +E E    + EE   +EEE
Sbjct: 572 VEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 605


>YDOF_SCHPO (O13734) Hypothetical protein C15A10.15 in chromosome I
          Length = 647

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/134 (24%), Positives = 61/134 (44%), Gaps = 18/134 (13%)

Query: 98  EIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSD---------LPSKKEPVASDKSEDVS 148
           +IR Y E IR I K Q  +I++L    E   + +         L  + E V ++  E+ +
Sbjct: 17  QIRQYKEIIR-ISKAQSIRIKELQLENERLLSENIDLRTTAINLEEQLETVQNENEENKT 75

Query: 149 K-------YRPNPDMLVSREDLAPQEGHDAYRPVKF-APTSMDQDKTSKQERNALRREKE 200
           K       +    D  +S+  L  QE  D ++PV+      +D D     E + ++  +E
Sbjct: 76  KLAALLNRFHEETDNFLSKLSLCQQEIQDTFKPVEANLAYDVDTDSEDLDEESVVKDTEE 135

Query: 201 ILKESKHSSFIRTL 214
           I+++++H   +R L
Sbjct: 136 IIEQAQHDVSLRNL 149


>RA50_PYRHO (O58687) DNA double-strand break repair rad50 ATPase
          Length = 879

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 48/204 (23%), Positives = 89/204 (43%), Gaps = 16/204 (7%)

Query: 92  VVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLPSKKEPVASDKSEDVSKYR 151
           +   I+EIR  L KI   D K+  +  +L+K   N    ++ S K+ V      +++ Y+
Sbjct: 501 IADQIIEIRERLSKINLEDLKRDKEEYELLKSESNKLKGEVESLKKEV-----NELNDYK 555

Query: 152 PNPDMLVSREDLAPQEGHDAY-RPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSF 210
                L    D A +E  +   R ++    ++D+   S + R   +   + ++       
Sbjct: 556 NESTKLEIEIDKAKKELSEIEDRLLRLGFKTIDE--LSGRIRELEKFHNKYIEAKNAEKE 613

Query: 211 IRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLK 270
           +R ++  ++++ EE+        ++E  I K+     Q  EL  +    K+E KREK +K
Sbjct: 614 LRDILESLKDEREELDKAFEELAKIETDIEKVTS---QLNELQRKFDQKKYEEKREKMMK 670

Query: 271 KSR--NGLDGLTESF---FDEIKT 289
            S    GL+   E      DEIK+
Sbjct: 671 LSMEIKGLETKLEELERRRDEIKS 694


>IF2P_SCHPO (Q10251) Eukaryotic translation initiation factor 5B
           (eIF-5B) (Translation initiation factor IF-2)
          Length = 1079

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 25/197 (12%)

Query: 125 ENAATSDLPSKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQ 184
           E AA  ++P  +     +K  +    +   + L  ++  A ++G      +  +  S + 
Sbjct: 165 EAAAPPEIPEVRVKTKKEKERE----KKEREKLRKKQQQAKKKGSTGEDTLASSEVSSEV 220

Query: 185 DKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEK------PEEIRDYEGSSKEVERH 238
           D ++  E ++  + K+     +    +  L   +EEK       + IR+ E    E E+ 
Sbjct: 221 DISTPAENDSSAKGKQAAGSKRKGPNVTALQKMLEEKRAREEEEQRIREEEARIAEEEKR 280

Query: 239 IAKMEERAWQEEELFNRVPLTKHERKRE------KYLKKSRNGLDGLTESFFDEIKTLPF 292
           +A++EE   +E  L  +    K  +K+E      KYL K +     L +    ++     
Sbjct: 281 LAEVEEARKEEARLKKK---EKERKKKEEMKAQGKYLSKKQKEQQALAQRRLQQML---- 333

Query: 293 EDETGEQVMGPSKGSNR 309
             E+G +V G S G  +
Sbjct: 334 --ESGVRVAGLSNGEKK 348


>KF3A_MOUSE (P28741) Kinesin-like protein KIF3A (Microtubule plus
           end-directed kinesin motor 3A)
          Length = 701

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 38/171 (22%), Positives = 77/171 (44%), Gaps = 13/171 (7%)

Query: 111 KKQQYQIQKLMKVGENAATSDLP-SKKEPVASDKSEDVSKYRPNPDML----VSREDLAP 165
           +K+  +++K ++ GE  + SD+  S+++    +  ED  K +   D      VS + +  
Sbjct: 364 QKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKRKKRRDQAGKKKVSPDKMVE 423

Query: 166 QEGH-DAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMNDIEEK--- 221
            +   D  R        M++++ +K      RREK++LK  +    +   ++ +E+K   
Sbjct: 424 MQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIV 483

Query: 222 --PEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERK--REKY 268
              + +   E   K +E    ++EER  + E+L   +   + ER    EKY
Sbjct: 484 GGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKY 534


>EEA1_MOUSE (Q8BL66) Early endosome antigen 1 (Fragment)
          Length = 790

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 47/233 (20%), Positives = 101/233 (43%), Gaps = 14/233 (6%)

Query: 14  KEKEASPLAALLKEMKEGLDVVRHKIQSLTAKVKEGQYPTADGFSYLEAKNLLLLNYCQS 73
           K+++   L ALL++ KE + ++  + + L AK++ G+  TA   + L+ KN  L      
Sbjct: 365 KDQKIQNLEALLQKGKESVSLLEKEREDLYAKIQAGEGETA-VLNQLQEKNHALQQQLTQ 423

Query: 74  LVYYLLRKAKGFSIEEHPVVRSIVEIRLYLEKIRPIDKKQQYQIQKLMKVGENAATSDLP 133
           L   L  +++     E  +   + E + +L   +      +  + +L        +S L 
Sbjct: 424 LTEKLKNQSESHKQAEENLHDQVQEQKAHLRAAQDRVLSLETSVSEL--------SSQLN 475

Query: 134 SKKEPVASDKSEDVSKYRPNPDMLVSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERN 193
             KE V    S+   + +   ++L+S E     +  D    +  A  ++ QDK  +  + 
Sbjct: 476 ESKEKV----SQLDIQIKAKTELLLSAEAAKAAQRADLQNHLDTAQHAL-QDKQQELNKV 530

Query: 194 ALRREKEILKESKHSSFIRTLMNDIEEKPEEIRDYEGSSKEVERHIAKMEERA 246
           +++ ++   K  +       L + +++  E+    E   +++E HI K+E  A
Sbjct: 531 SVQLDQLTAKFQEKQEHCIQLESHLKDHKEKHLSLEQKVEDLEGHIKKLEADA 583


>IF2_VIBVY (Q7MI09) Translation initiation factor IF-2
          Length = 907

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 45/221 (20%), Positives = 85/221 (38%), Gaps = 6/221 (2%)

Query: 100 RLYLEKIRPIDKKQQYQIQKLMKVGENAA--TSDLPSKKEPVASDKSEDVSKYRPNPDML 157
           R Y+++    D+ ++   +   +  E AA   ++  +K+E   + K E   K +   +  
Sbjct: 95  RTYVKRSAIEDEAKREAEEAAQREAEEAAKRAAEEAAKREAEEAAKREAEEKAKREAEEA 154

Query: 158 VSREDLAPQEGHDAYRPVKFAPTSMDQDKTSKQERNALRREKEILKESKHSSFIRTLMND 217
             RE     +     +  + A     +D   K ++ A R+E E LK  +     R    +
Sbjct: 155 AKREAEKSVDRDAEEKAKRDAEGKAKRDAEEKVKQEAARKEAEELKRRQEEEAKRKAEEE 214

Query: 218 IEEKPEEIRDYEGSSKEVERHIAKMEERAWQEEELFNRVPLTKHERKREKYLKKSRNGLD 277
            + K EE R+    +KE     +  EE     E+    V  +++ R+ E    +      
Sbjct: 215 SQRKLEEAREMAEKNKE---RWSAAEENKGDMEDTDYHVTTSQYAREAEDEADRKEEEAR 271

Query: 278 GLTESFFDEIKTLPFEDETGEQVMGPSKGSNRNGRLKKRKA 318
              +      K    ++  G +V    KG  R G+L K K+
Sbjct: 272 RRKKKTKSSAKASENDERGGPRVQRGGKG-GRKGKLSKPKS 311


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.311    0.130    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,896,008
Number of Sequences: 164201
Number of extensions: 1655527
Number of successful extensions: 6234
Number of sequences better than 10.0: 275
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 251
Number of HSP's that attempted gapping in prelim test: 5763
Number of HSP's gapped (non-prelim): 574
length of query: 318
length of database: 59,974,054
effective HSP length: 110
effective length of query: 208
effective length of database: 41,911,944
effective search space: 8717684352
effective search space used: 8717684352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)