BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0310b.14
(587 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
2AAA_PEA (P36875) Protein phosphatase PP2A regulatory subunit A ... 720 0.0
2AAA_PIG (P54612) Serine/threonine protein phosphatase 2A, 65 kD... 663 0.0
2AAA_MOUSE (Q76MZ3) Serine/threonine protein phosphatase 2A, 65 ... 663 0.0
2AAA_HUMAN (P30153) Serine/threonine protein phosphatase 2A, 65 ... 661 0.0
2AAB_PIG (P54613) Serine/threonine protein phosphatase 2A, 65 kD... 646 0.0
2AAB_HUMAN (P30154) Serine/threonine protein phosphatase 2A, 65 ... 638 0.0
2AAA_DROME (P36179) Protein phosphatase PP2A, 65 kDa regulatory ... 633 0.0
2AAA_SCHPO (Q9UT08) Protein phosphatase PP2A regulatory subunit ... 567 e-161
2AAA_CAEEL (Q09543) Probable protein phosphatase PP2A regulatory... 545 e-154
2AAA_YEAST (P31383) Protein phosphatase PP2A regulatory subunit ... 479 e-135
P4R1_RAT (Q8VI02) Serine/threonine phosphatase 4 regulatory subu... 74 1e-12
P4R1_MOUSE (Q8K2V1) Serine/threonine phosphatase 4 regulatory su... 73 2e-12
P4R1_HUMAN (Q8TF05) Serine/threonine phosphatase 4 regulatory su... 73 2e-12
PP4L_HUMAN (Q9P1A2) Serine/threonine phosphatase 4 regulatory su... 65 6e-10
S3B1_SCHPO (Q10178) U2 snRNP component prp10 47 1e-04
GCN1_YEAST (P33892) Translational activator GCN1 45 7e-04
S3B1_XENLA (O57683) Splicing factor 3B subunit 1 (Spliceosome as... 44 0.001
S3B1_MOUSE (Q99NB9) Splicing factor 3B subunit 1 (Spliceosome as... 44 0.001
S3B1_HUMAN (O75533) Splicing factor 3B subunit 1 (Spliceosome as... 44 0.001
IMB1_HUMAN (Q14974) Importin beta-1 subunit (Karyopherin beta-1 ... 44 0.002
>2AAA_PEA (P36875) Protein phosphatase PP2A regulatory subunit A
(PR65) (Fragment)
Length = 395
Score = 720 bits (1859), Expect = 0.0
Identities = 372/395 (94%), Positives = 385/395 (97%), Gaps = 1/395 (0%)
Query: 194 VEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQDK 253
VEAAHLK+DIMSVFDDLTQDDQDS R LAVEGCAALGKLLEPQ+C+AHILPVIVNFSQDK
Sbjct: 1 VEAAHLKTDIMSVFDDLTQDDQDSFRFLAVEGCAALGKLLEPQDCLAHILPVIVNFSQDK 60
Query: 254 SWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILSP 313
SWRVRYMVANQLYELCEAVGP+ T+TELVPAYVRLLRDN AEVRIAAAGKV+KFSRILSP
Sbjct: 61 SWRVRYMVANQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAGKVSKFSRILSP 120
Query: 314 ELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPD 373
ELAI+HILPCVKELS DSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPD
Sbjct: 121 ELAIQHILPCVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPD 180
Query: 374 VRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFF 433
VRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFF
Sbjct: 181 VRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFF 240
Query: 434 DDKLGALCMQWLKDKVYSIRDAAANNVKRL-AEEFGPDWAMQHIIPQVLDMINDPHYLYR 492
DDKLGAL MQWLKDK YSIR+AAANNVKRL AEEFGP+WAMQHIIPQVLDMINDPHYLYR
Sbjct: 241 DDKLGALIMQWLKDKEYSIRNAAANNVKRLAAEEFGPEWAMQHIIPQVLDMINDPHYLYR 300
Query: 493 MTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVVEN 552
MTIL AISLLAPVLGSEITS+ LLPLVVNASKDRVPNIKFNVAKVLQSLIPIV+ESVVE+
Sbjct: 301 MTILHAISLLAPVLGSEITSTNLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVDESVVES 360
Query: 553 TLRPCLVELSEDPDVDVRFFASQALQSSDQVKMSS 587
T+RPCLVELSEDPDVDVRFFASQALQSSDQVKMSS
Sbjct: 361 TIRPCLVELSEDPDVDVRFFASQALQSSDQVKMSS 395
Score = 112 bits (281), Expect = 2e-24
Identities = 82/369 (22%), Positives = 159/369 (42%), Gaps = 41/369 (11%)
Query: 87 LLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVEHFIPLVKRLAAGE-WFTARVSS 145
++ + L ++ R +VE +G + QD + H +P++ + + W + +
Sbjct: 10 IMSVFDDLTQDDQDSFRFLAVEGCAALGKLLEPQDCLAHILPVIVNFSQDKSWRVRYMVA 69
Query: 146 CGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAATNLGKFAATVEAAHLKSDIMS 205
L+ + P++ K EL Y +L +D++ VR +AA + KF+ + I+
Sbjct: 70 NQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAGKVSKFSRILSPELAIQHILP 129
Query: 206 VFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQDKSWRVRYMVANQL 265
+L+ D VR + +L + +LP+ ++ +D+ VR + ++L
Sbjct: 130 CVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKL 189
Query: 266 YELCEAVGPEPTRTELVPAYVRL------------------------------------- 288
++ + +G + L+PA V L
Sbjct: 190 DQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALIM 249
Query: 289 --LRDNEAEVRIAAAGKVTKF-SRILSPELAIEHILPCVKELSADSSQHVRSALASVIMG 345
L+D E +R AAA V + + PE A++HI+P V ++ D R + I
Sbjct: 250 QWLKDKEYSIRNAAANNVKRLAAEEFGPEWAMQHIIPQVLDMINDPHYLYRMTILHAISL 309
Query: 346 MAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVEL 405
+APVLG + T LLP+ ++ KD P+++ N+ L + ++ ++ ++ P +VEL
Sbjct: 310 LAPVLGSEITSTNLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVDESVVESTIRPCLVEL 369
Query: 406 AEDRHWRVR 414
+ED VR
Sbjct: 370 SEDPDVDVR 378
Score = 75.9 bits (185), Expect = 3e-13
Identities = 75/381 (19%), Positives = 154/381 (39%), Gaps = 42/381 (11%)
Query: 11 IAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIP-FLSENNDDDDEVLLAMAE 69
+ V+++ +++ ++R +L + A+G + T+ EL+P ++ D+ EV +A A
Sbjct: 50 LPVIVNFSQDKSWRVRYMVANQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAG 109
Query: 70 ELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVEHFIPL 129
++ F + +L P L ++H +P
Sbjct: 110 KVSKF---------SRILSPEL------------------------------AIQHILPC 130
Query: 130 VKRLAAGEWFTARVSSCG-LFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAATNLG 188
VK L+ R + + +A +A +L ++ L +D+ P VR + + L
Sbjct: 131 VKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLD 190
Query: 189 KFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVN 248
+ + L ++ +L +D VRL +E L L + +I+
Sbjct: 191 QVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALIMQ 250
Query: 249 FSQDKSWRVRYMVANQLYEL-CEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKF 307
+ +DK + +R AN + L E GPE ++P + ++ D R+ ++
Sbjct: 251 WLKDKEYSIRNAAANNVKRLAAEEFGPEWAMQHIIPQVLDMINDPHYLYRMTILHAISLL 310
Query: 308 SRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+ +L E+ ++LP V S D +++ +A V+ + P++ + + P + L
Sbjct: 311 APVLGSEITSTNLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVDESVVESTIRPCLVELS 370
Query: 368 KDEFPDVRLNIISKLDQVNQV 388
+D DVR L +QV
Sbjct: 371 EDPDVDVRFFASQALQSSDQV 391
>2AAA_PIG (P54612) Serine/threonine protein phosphatase 2A, 65 kDa
regulatory subunit A, alpha isoform (PP2A, subunit A,
PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform)
Length = 588
Score = 663 bits (1711), Expect = 0.0
Identities = 339/577 (58%), Positives = 442/577 (75%), Gaps = 4/577 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+QLRLNSI++LSTIA ALG ERTR EL+PFL++ D+DEVL
Sbjct: 6 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVL 65
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
LA+AE+LG F VGG E+ + LLPPLE+L TVEET VRDK+VESL I + DL
Sbjct: 66 LALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEA 125
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
HF+PLVKRLA G+WFT+R S+CGLF + YP A KAELR + LC DD PMVRR+AA
Sbjct: 126 HFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAA 185
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
+ LG+FA +E ++KS+I+ +F +L D+QDSVRLLAVE C + +LL ++ A ++P
Sbjct: 186 SKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMP 245
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+ ++DKSWRVRYMVA++ EL +AVGPE T+T+LVPA+ L++D EAEVR AA+ KV
Sbjct: 246 TLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKV 305
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+F LS + + + ILPC+KEL +D++QHV+SALASVIMG++P+LGKD TIE LL
Sbjct: 306 KEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLL 365
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
P+FL+ LKDE P+VRLNIIS LD VN+VIGI LSQSLLPAIVELAED WRVRLAIIEY
Sbjct: 366 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 425
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLA QLGV FFD+KL +LCM WL D VY+IR+AA +N+K+L E+FG +WA IIP+V
Sbjct: 426 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKV 485
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
L M DP+YL+RMT L I++L+ V G +IT+ +LP V+ + D V N++FNVAK LQ
Sbjct: 486 LAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQK 545
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ PI++ S +++ ++P L +L++D DVDV++FA +AL
Sbjct: 546 IGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 582
Score = 92.4 bits (228), Expect = 3e-18
Identities = 90/413 (21%), Positives = 165/413 (39%), Gaps = 44/413 (10%)
Query: 57 NDDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQ 116
+DD V A A +LG F + + ++P L + E+ VR +VE+ I
Sbjct: 174 SDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQL 233
Query: 117 MREQDLVEHFIPLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQLCQDD 175
+ ++DL +P +++ A + + R F + PE K +L + L +D
Sbjct: 234 LPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDC 293
Query: 176 MPMVRRSAATNLGKFAATVEA-----------------------AHLKSDIMSVFDDLT- 211
VR +A+ + +F + A H+KS + SV L+
Sbjct: 294 EAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSP 353
Query: 212 -------------------QDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQD 252
+D+ VRL + + +++ ++ +LP IV ++D
Sbjct: 354 ILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 413
Query: 253 KSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILS 312
WRVR + + L +G E +L + L D+ +R AA + K
Sbjct: 414 AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFG 473
Query: 313 PELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFP 372
E A I+P V +S D + R I ++ V G+D T + +LP L + D
Sbjct: 474 KEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVA 533
Query: 373 DVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
+VR N+ L ++ ++ L + P + +L +D+ V+ E + +L+
Sbjct: 534 NVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLS 586
Score = 56.6 bits (135), Expect = 2e-07
Identities = 60/290 (20%), Positives = 117/290 (39%), Gaps = 2/290 (0%)
Query: 289 LRDNEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAP 348
LR+ + ++R+ + K++ + L E +LP + + D + V ALA +
Sbjct: 19 LRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDE-VLLALAEQLGTFTT 77
Query: 349 VLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAED 408
++G + LLP SL E VR + L ++ L +P + LA
Sbjct: 78 LVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGG 137
Query: 409 RHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFG 468
+ R + + ++ +L D +R AAA+ + A+
Sbjct: 138 DWFTSRTSACGLFSVCYPRVSSAV-KAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLE 196
Query: 469 PDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVP 528
D IIP ++ +D R+ ++A +A +L E + ++P + A++D+
Sbjct: 197 LDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSW 256
Query: 529 NIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQ 578
+++ VA L V + + L P L +D + +VR AS ++
Sbjct: 257 RVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVK 306
>2AAA_MOUSE (Q76MZ3) Serine/threonine protein phosphatase 2A, 65 kDa
regulatory subunit A, alpha isoform (PP2A, subunit A,
PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform)
Length = 588
Score = 663 bits (1711), Expect = 0.0
Identities = 339/577 (58%), Positives = 442/577 (75%), Gaps = 4/577 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+QLRLNSI++LSTIA ALG ERTR EL+PFL++ D+DEVL
Sbjct: 6 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVL 65
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
LA+AE+LG F VGG E+ + LLPPLE+L TVEET VRDK+VESL I + DL
Sbjct: 66 LALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEA 125
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
HF+PLVKRLA G+WFT+R S+CGLF + YP A KAELR + LC DD PMVRR+AA
Sbjct: 126 HFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAA 185
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
+ LG+FA +E ++KS+I+ +F +L D+QDSVRLLAVE C + +LL ++ A ++P
Sbjct: 186 SKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMP 245
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+ ++DKSWRVRYMVA++ EL +AVGPE T+T+LVPA+ L++D EAEVR AA+ KV
Sbjct: 246 TLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKV 305
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+F LS + + + ILPC+KEL +D++QHV+SALASVIMG++P+LGKD TIE LL
Sbjct: 306 KEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLL 365
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
P+FL+ LKDE P+VRLNIIS LD VN+VIGI LSQSLLPAIVELAED WRVRLAIIEY
Sbjct: 366 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 425
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLA QLGV FFD+KL +LCM WL D VY+IR+AA +N+K+L E+FG +WA IIP+V
Sbjct: 426 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKV 485
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
L M DP+YL+RMT L I++L+ V G +IT+ +LP V+ + D V N++FNVAK LQ
Sbjct: 486 LAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQK 545
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ PI++ S +++ ++P L +L++D DVDV++FA +AL
Sbjct: 546 IGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 582
Score = 92.4 bits (228), Expect = 3e-18
Identities = 90/413 (21%), Positives = 165/413 (39%), Gaps = 44/413 (10%)
Query: 57 NDDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQ 116
+DD V A A +LG F + + ++P L + E+ VR +VE+ I
Sbjct: 174 SDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQL 233
Query: 117 MREQDLVEHFIPLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQLCQDD 175
+ ++DL +P +++ A + + R F + PE K +L + L +D
Sbjct: 234 LPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDC 293
Query: 176 MPMVRRSAATNLGKFAATVEA-----------------------AHLKSDIMSVFDDLT- 211
VR +A+ + +F + A H+KS + SV L+
Sbjct: 294 EAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSP 353
Query: 212 -------------------QDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQD 252
+D+ VRL + + +++ ++ +LP IV ++D
Sbjct: 354 ILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 413
Query: 253 KSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILS 312
WRVR + + L +G E +L + L D+ +R AA + K
Sbjct: 414 AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFG 473
Query: 313 PELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFP 372
E A I+P V +S D + R I ++ V G+D T + +LP L + D
Sbjct: 474 KEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVA 533
Query: 373 DVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
+VR N+ L ++ ++ L + P + +L +D+ V+ E + +L+
Sbjct: 534 NVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLS 586
Score = 56.6 bits (135), Expect = 2e-07
Identities = 60/290 (20%), Positives = 117/290 (39%), Gaps = 2/290 (0%)
Query: 289 LRDNEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAP 348
LR+ + ++R+ + K++ + L E +LP + + D + V ALA +
Sbjct: 19 LRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDE-VLLALAEQLGTFTT 77
Query: 349 VLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAED 408
++G + LLP SL E VR + L ++ L +P + LA
Sbjct: 78 LVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGG 137
Query: 409 RHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFG 468
+ R + + ++ +L D +R AAA+ + A+
Sbjct: 138 DWFTSRTSACGLFSVCYPRVSSAV-KAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLE 196
Query: 469 PDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVP 528
D IIP ++ +D R+ ++A +A +L E + ++P + A++D+
Sbjct: 197 LDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSW 256
Query: 529 NIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQ 578
+++ VA L V + + L P L +D + +VR AS ++
Sbjct: 257 RVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVK 306
>2AAA_HUMAN (P30153) Serine/threonine protein phosphatase 2A, 65 kDa
regulatory subunit A, alpha isoform (PP2A, subunit A,
PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform)
(Medium tumor antigen-associated 61 kDa protein)
Length = 588
Score = 661 bits (1706), Expect = 0.0
Identities = 338/577 (58%), Positives = 441/577 (75%), Gaps = 4/577 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+QLRLNSI++LSTIA ALG ERTR EL+PFL++ D+DEVL
Sbjct: 6 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVL 65
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
LA+AE+LG F VGG E+ + LLPPLE+L TVEET VRDK+VESL I + DL
Sbjct: 66 LALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEA 125
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
HF+PLVKRLA G+WFT+R S+CGLF + YP A KAELR + LC DD PMVRR+AA
Sbjct: 126 HFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAA 185
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
+ LG+FA +E ++KS+I+ +F +L D+QDSVRLLAVE C + +LL ++ A ++P
Sbjct: 186 SKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMP 245
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+ ++DKSW VRYMVA++ EL +AVGPE T+T+LVPA+ L++D EAEVR AA+ KV
Sbjct: 246 TLRQAAEDKSWAVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKV 305
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+F LS + + + ILPC+KEL +D++QHV+SALASVIMG++P+LGKD TIE LL
Sbjct: 306 KEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLL 365
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
P+FL+ LKDE P+VRLNIIS LD VN+VIGI LSQSLLPAIVELAED WRVRLAIIEY
Sbjct: 366 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 425
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLA QLGV FFD+KL +LCM WL D VY+IR+AA +N+K+L E+FG +WA IIP+V
Sbjct: 426 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKV 485
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
L M DP+YL+RMT L I++L+ V G +IT+ +LP V+ + D V N++FNVAK LQ
Sbjct: 486 LAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQK 545
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ PI++ S +++ ++P L +L++D DVDV++FA +AL
Sbjct: 546 IGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 582
Score = 92.8 bits (229), Expect = 2e-18
Identities = 90/413 (21%), Positives = 165/413 (39%), Gaps = 44/413 (10%)
Query: 57 NDDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQ 116
+DD V A A +LG F + + ++P L + E+ VR +VE+ I
Sbjct: 174 SDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQL 233
Query: 117 MREQDLVEHFIPLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQLCQDD 175
+ ++DL +P +++ A + + R F + PE K +L + L +D
Sbjct: 234 LPQEDLEALVMPTLRQAAEDKSWAVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDC 293
Query: 176 MPMVRRSAATNLGKFAATVEA-----------------------AHLKSDIMSVFDDLT- 211
VR +A+ + +F + A H+KS + SV L+
Sbjct: 294 EAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSP 353
Query: 212 -------------------QDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQD 252
+D+ VRL + + +++ ++ +LP IV ++D
Sbjct: 354 ILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAED 413
Query: 253 KSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILS 312
WRVR + + L +G E +L + L D+ +R AA + K
Sbjct: 414 AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFG 473
Query: 313 PELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFP 372
E A I+P V +S D + R I ++ V G+D T + +LP L + D
Sbjct: 474 KEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVA 533
Query: 373 DVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
+VR N+ L ++ ++ L + P + +L +D+ V+ E + +L+
Sbjct: 534 NVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLS 586
Score = 55.8 bits (133), Expect = 3e-07
Identities = 60/290 (20%), Positives = 117/290 (39%), Gaps = 2/290 (0%)
Query: 289 LRDNEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAP 348
LR+ + ++R+ + K++ + L E +LP + + D + V ALA +
Sbjct: 19 LRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDE-VLLALAEQLGTFTT 77
Query: 349 VLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAED 408
++G + LLP SL E VR + L ++ L +P + LA
Sbjct: 78 LVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGG 137
Query: 409 RHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFG 468
+ R + + ++ +L D +R AAA+ + A+
Sbjct: 138 DWFTSRTSACGLFSVCYPRVSSAV-KAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLE 196
Query: 469 PDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVP 528
D IIP ++ +D R+ ++A +A +L E + ++P + A++D+
Sbjct: 197 LDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSW 256
Query: 529 NIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQ 578
+++ VA L V + + L P L +D + +VR AS ++
Sbjct: 257 AVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVK 306
>2AAB_PIG (P54613) Serine/threonine protein phosphatase 2A, 65 kDa
regulatory subunit A, beta isoform (PP2A, subunit A,
PR65-beta isoform) (PP2A, subunit A, R1-beta isoform)
(Fragment)
Length = 602
Score = 646 bits (1667), Expect = 0.0
Identities = 330/577 (57%), Positives = 436/577 (75%), Gaps = 4/577 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+QLRLNSI++LSTIA ALG ERTR EL+PFL++ D+DEVL
Sbjct: 20 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVL 79
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
LA+AE+LG F VGG + A+ LLPPLE+L TVEET VRDK+VESL +I + L
Sbjct: 80 LALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEA 139
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
HF+PLVKRLA+G+WFT+R S+CGLF + YP A A KAE+R + LC DD PMVRR+AA
Sbjct: 140 HFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAA 199
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
+ LG+FA +E +KS+I+ +F +L D+QDSVRLLAVE C ++ +LL + A ++P
Sbjct: 200 SKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMP 259
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+ ++DKSWRVRYMVA++ EL AVGP+ T +L+PA+ LL+D EAEVR AAA KV
Sbjct: 260 TLRQAAEDKSWRVRYMVADKFSELQRAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKV 319
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+ L E + + ILPC+KEL +D++QHV+SALASVIMG++ +LGK+ TIE LL
Sbjct: 320 KELCENLPIEGRETIIMNQILPCIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLL 379
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
P+FL+ LKDE P+VRLNIIS LD VN+VIGI LSQSLLPAIVELAED WRVRLAIIEY
Sbjct: 380 PLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 439
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLA QLGV FFD+KL +LCM WL D VY+IR+AA NN+ +L ++FG +WA I+P+V
Sbjct: 440 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKV 499
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
L M NDP+YL+RMT L I++L+ G EIT+ ++LP+V+ + D+V N++FNVAK LQ
Sbjct: 500 LVMANDPNYLHRMTTLFCINVLSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQK 559
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ PI++ ++ ++P L +L +D D+DV++FA +A+
Sbjct: 560 IGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAI 596
Score = 89.7 bits (221), Expect = 2e-17
Identities = 91/418 (21%), Positives = 167/418 (39%), Gaps = 44/418 (10%)
Query: 52 FLSENNDDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLC 111
F S +DD V A A +LG F + + ++P L + E+ VR +VE+
Sbjct: 183 FRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACV 242
Query: 112 RIGAQMREQDLVEHFIPLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQ 170
I + + DL +P +++ A + + R F + P+ +L +
Sbjct: 243 SIAQLLSQDDLEALVMPTLRQAAEDKSWRVRYMVADKFSELQRAVGPKITLNDLIPAFQN 302
Query: 171 LCQDDMPMVRRSAATNLGKFAATVEAA-----------------------HLKSDIMSVF 207
L +D VR +AA + + + H+KS + SV
Sbjct: 303 LLKDCEAEVRAAAAHKVKELCENLPIEGRETIIMNQILPCIKELVSDTNQHVKSALASVI 362
Query: 208 DDLT--------------------QDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIV 247
L+ +D+ VRL + + +++ ++ +LP IV
Sbjct: 363 MGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIV 422
Query: 248 NFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKF 307
++D WRVR + + L +G E +L + L D+ +R AA + K
Sbjct: 423 ELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKL 482
Query: 308 SRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+ E A I+P V ++ D + R I ++ G++ T +Q+LPI L +
Sbjct: 483 VQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINVLSEACGQEITTKQMLPIVLKMA 542
Query: 368 KDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
D+ +VR N+ L ++ ++ D L + + P + +L +D V+ E I +LA
Sbjct: 543 GDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISVLA 600
Score = 58.9 bits (141), Expect = 4e-08
Identities = 63/293 (21%), Positives = 119/293 (40%), Gaps = 8/293 (2%)
Query: 289 LRDNEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAP 348
LR+ + ++R+ + K++ + L E +LP + + D + V ALA +
Sbjct: 33 LRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDE-VLLALAEQLGNFTG 91
Query: 349 VLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAED 408
++G LLP SL E VR + L Q++Q L +P + LA
Sbjct: 92 LVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASG 151
Query: 409 RHWRVRLAIIEYIPLL---ASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAE 465
+ R + + AS +LC D +R AAA+ + A+
Sbjct: 152 DWFTSRTSACGLFSVCYPRASNAVKAEIRQHFRSLC----SDDTPMVRRAAASKLGEFAK 207
Query: 466 EFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKD 525
D I+P ++ +D R+ ++A +A +L + + ++P + A++D
Sbjct: 208 VLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMPTLRQAAED 267
Query: 526 RVPNIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQ 578
+ +++ VA L V + N L P L +D + +VR A+ ++
Sbjct: 268 KSWRVRYMVADKFSELQRAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVK 320
>2AAB_HUMAN (P30154) Serine/threonine protein phosphatase 2A, 65 kDa
regulatory subunit A, beta isoform (PP2A, subunit A,
PR65-beta isoform) (PP2A, subunit A, R1-beta isoform)
Length = 601
Score = 638 bits (1646), Expect = 0.0
Identities = 327/577 (56%), Positives = 432/577 (74%), Gaps = 4/577 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+QLRLNSI++LSTIA ALG ERTR EL+PFL++ D+DEVL
Sbjct: 19 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVL 78
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
LA+AE+LG F VGG + A+ LLPPLE L TVEET VRDK+VESL +I + L
Sbjct: 79 LALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEA 138
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
+F+PLVKRLA+G+WFT+R S+CGLF + YP A A KAE R + LC DD PMVRR+AA
Sbjct: 139 YFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAETRQQFRSLCSDDTPMVRRAAA 198
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
+ LG+FA +E +KS+I+ +F L D+QDSVRLLAVE C ++ +LL + ++P
Sbjct: 199 SKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMP 258
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+ ++DKSWRVRYMVA++ EL +A+GP+ T +L+PA+ LL+D EAEVR AAA KV
Sbjct: 259 TLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKV 318
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+ L E + + ILP +KEL +D++QHV+SALASVIMG++ +LGK+ TIE LL
Sbjct: 319 KELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLL 378
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
P+FL+ LKDE PDVRLNIIS LD VN+VIGI LSQSLLPAIVELAED WRVRLAIIEY
Sbjct: 379 PLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 438
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLA QLGV FFD+KL +LCM WL D VY+IR+AA NN+ +L ++FG +WA I+P+V
Sbjct: 439 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKV 498
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
L M NDP+YL+RMT L I+ L+ G EIT+ ++LP+V+ + D+V N++FNVAK LQ
Sbjct: 499 LVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQK 558
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ PI++ + ++ ++P L +L +D D+DV++FA +A+
Sbjct: 559 IGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAI 595
Score = 88.2 bits (217), Expect = 5e-17
Identities = 90/418 (21%), Positives = 167/418 (39%), Gaps = 44/418 (10%)
Query: 52 FLSENNDDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLC 111
F S +DD V A A +LG F + + ++P +L + E+ VR +VE+
Sbjct: 182 FRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACV 241
Query: 112 RIGAQMREQDLVEHFIPLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQ 170
I + + DL +P +++ A + + R F + P+ +L +
Sbjct: 242 SIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQN 301
Query: 171 LCQDDMPMVRRSAATNLGKFAATVEAA-----------------------HLKSDIMSVF 207
L +D VR +AA + + + H+KS + SV
Sbjct: 302 LLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVI 361
Query: 208 DDLT--------------------QDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIV 247
L+ +D+ VRL + + +++ ++ +LP IV
Sbjct: 362 MGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIV 421
Query: 248 NFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKF 307
++D WRVR + + L +G E +L + L D+ +R AA + K
Sbjct: 422 ELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKL 481
Query: 308 SRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+ E A I+P V ++ D + R I ++ G++ T +Q+LPI L +
Sbjct: 482 VQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMA 541
Query: 368 KDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
D+ +VR N+ L ++ ++ + L + P + +L +D V+ E I +LA
Sbjct: 542 GDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLA 599
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/293 (20%), Positives = 119/293 (39%), Gaps = 8/293 (2%)
Query: 289 LRDNEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAP 348
LR+ + ++R+ + K++ + L E +LP + + D + V ALA +
Sbjct: 32 LRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDE-VLLALAEQLGNFTG 90
Query: 349 VLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAED 408
++G LLP +L E VR + L Q++Q L +P + LA
Sbjct: 91 LVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASG 150
Query: 409 RHWRVRLAIIEYIPLL---ASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAE 465
+ R + + AS + +LC D +R AAA+ + A+
Sbjct: 151 DWFTSRTSACGLFSVCYPRASNAVKAETRQQFRSLC----SDDTPMVRRAAASKLGEFAK 206
Query: 466 EFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKD 525
D I+P + +D R+ ++A +A +L + + ++P + A++D
Sbjct: 207 VLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAED 266
Query: 526 RVPNIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQ 578
+ +++ VA L + + N L P L +D + +VR A+ ++
Sbjct: 267 KSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVK 319
>2AAA_DROME (P36179) Protein phosphatase PP2A, 65 kDa regulatory
subunit (Protein phosphatase PP2A regulatory subunit A)
(PR65)
Length = 590
Score = 633 bits (1633), Expect = 0.0
Identities = 337/579 (58%), Positives = 425/579 (73%), Gaps = 6/579 (1%)
Query: 4 VDQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEV 63
VD LYPIAVLIDELKNED+QLRLNSI++LSTIA ALGEERTR ELIPFL+E D+DEV
Sbjct: 7 VDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDEDEV 66
Query: 64 LLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLV 123
LLA+A++LG F VGG E A L+PPLE+L TVEET VRDK+VESL + A+ QDL
Sbjct: 67 LLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLE 126
Query: 124 EHFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSA 183
H +P ++RL +G+WFT+R S+CGLF + YP + KAELRA + +LCQD+ PMVRR+A
Sbjct: 127 IHVVPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAA 186
Query: 184 ATNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAH-I 242
A LG+FA VE +LKSD++ F L QDDQDSVRLLAVE C +LL PQ+ V H +
Sbjct: 187 ANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVTSAQLL-PQDDVEHLV 245
Query: 243 LPVIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAG 302
LP + + D SWRVRYMVA + +L +AVGPE TR +LVPA+ LL+D EAEVR A A
Sbjct: 246 LPTLRQCASDSSWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVAT 305
Query: 303 KVTKF----SRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQ 358
KV F ++ ++ + ILP V++L +D + HV+SALASVIMG++P+LG T+EQ
Sbjct: 306 KVKDFCANLDKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQ 365
Query: 359 LLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAII 418
LLP+FL LKDE P+VRLNIIS LD VN VIGI LSQSLLPAIVELAED WRVRLAII
Sbjct: 366 LLPLFLIQLKDECPEVRLNIISNLDCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAII 425
Query: 419 EYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIP 478
EY+P LA QLG FFD KL LCM WL D VY+IR+AA N+K+L E+FG WA Q IIP
Sbjct: 426 EYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIREAATLNMKKLVEQFGAPWAEQAIIP 485
Query: 479 QVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVL 538
+L M + +YL+RMT L +++LA V G++IT+ LLP V+ + D V N++FNVAK L
Sbjct: 486 MILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTL 545
Query: 539 QSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
Q + P +E SV++ ++P L +L+ D DVDV+ FA+QA+
Sbjct: 546 QKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAI 584
Score = 85.5 bits (210), Expect = 4e-16
Identities = 90/413 (21%), Positives = 172/413 (40%), Gaps = 7/413 (1%)
Query: 58 DDDDEVLLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQM 117
D+ V A A +LG F V + L+P L ++ VR +VE+ C AQ+
Sbjct: 177 DETPMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEA-CVTSAQL 235
Query: 118 REQDLVEHFI-PLVKRLAAGEWFTARVSSCGLF-HIAYPSAPEAQKAELRAMYGQLCQDD 175
QD VEH + P +++ A+ + R F + PE + +L + L +D
Sbjct: 236 LPQDDVEHLVLPTLRQCASDSSWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDA 295
Query: 176 MPMVRRSAATNLGKFAATVEAAH----LKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGK 231
VR + AT + F A ++ + + S I+ DL D V+ L
Sbjct: 296 EAEVRAAVATKVKDFCANLDKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSP 355
Query: 232 LLEPQECVAHILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRD 291
+L + V +LP+ + +D+ VR + + L + + +G + L+PA V L D
Sbjct: 356 MLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDVIGIQQLSQSLLPAIVELAED 415
Query: 292 NEAEVRIAAAGKVTKFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLG 351
++ VR+A + + L E + + D +R A + + G
Sbjct: 416 SKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIREAATLNMKKLVEQFG 475
Query: 352 KDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHW 411
+ ++P+ L + +++ R+ + L+ + +V G D+ ++ LLP ++ LA D
Sbjct: 476 APWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVA 535
Query: 412 RVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLA 464
VR + + + ++ L D ++ + D ++ AA + +A
Sbjct: 536 NVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAIAGIA 588
>2AAA_SCHPO (Q9UT08) Protein phosphatase PP2A regulatory subunit A
(PR65) (Protein phosphatase 2A 65 kDa regulatory
subunit)
Length = 590
Score = 567 bits (1462), Expect = e-161
Identities = 297/580 (51%), Positives = 406/580 (69%), Gaps = 6/580 (1%)
Query: 8 LYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVLLAM 67
LYPIAVLIDELK+++I RLN++ RLSTIA ALG ERTR ELIPFL E+ DD+DEVL A+
Sbjct: 10 LYPIAVLIDELKHDEITYRLNALERLSTIALALGPERTRDELIPFLDESIDDEDEVLSAL 69
Query: 68 AEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVEHFI 127
A++LG F+ YVGG E+A+VLL PLE L EET VRDK+V+SL ++ + ++ L ++F+
Sbjct: 70 ADQLGNFVDYVGGPEYAHVLLSPLENLAATEETVVRDKAVDSLNKVCICLSQEQLEQYFV 129
Query: 128 PLVKRLAAGEWFTARVSSCGLFHIAYPSAPE-AQKAELRAMYGQLCQDDMPMVRRSAATN 186
PLV+RL+ EWFT+R SS GL+ AY + A K LR + LC D+ PMVRR AATN
Sbjct: 130 PLVQRLSTAEWFTSRASSAGLYCAAYSQSENPAVKVSLRQSFSHLCHDEAPMVRRPAATN 189
Query: 187 LGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAH-ILPV 245
KF V + + +F+ L+ DDQDSVRLL+ + +L ++L+ + H +L
Sbjct: 190 CAKFVFLVTKQEAIDEFIPLFNSLSNDDQDSVRLLSFDIMVSLAEVLKSDSEIRHYLLQP 249
Query: 246 IVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVT 305
+ +F D SWR RYMVA +L + VGP + EL+ +V L++D E EVR A A ++
Sbjct: 250 LRSFVSDSSWRTRYMVAANFVKLAKVVGPSLIKDELIKPFVLLMKDTEQEVRRAIATQIP 309
Query: 306 KFSRILSPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLS 365
F +L + +E I+P ++EL D +QHVR+AL I +AP LGK+ T E LLP+FL
Sbjct: 310 GFCELLDKRIVLEEIIPVIQELINDPAQHVRAALGMNIGALAPQLGKEKTTEYLLPMFLE 369
Query: 366 LLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLA 425
LLKDE P+VRLNIISKL+ VN+V+GI+LLSQSLLPAIV LAED+ WRVRLAII+YIPLLA
Sbjct: 370 LLKDENPEVRLNIISKLEVVNKVVGIELLSQSLLPAIVTLAEDKQWRVRLAIIDYIPLLA 429
Query: 426 SQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMIN 485
QLGV FF++K+G LCM WL+D VYSIR+AA N+++L E FG +WA + IIP+ L M +
Sbjct: 430 QQLGVEFFNEKMGNLCMSWLEDHVYSIREAAIKNLRKLTEIFGLEWATETIIPKFLAMRS 489
Query: 486 DPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIV 545
P+YLYRMT + AIS +AP L +E+ ++LP + D +PNI+FNVAK + L P++
Sbjct: 490 HPNYLYRMTTIFAISEIAPALNAEVIEKQILPTLEQLVNDPIPNIRFNVAKAFEVLKPVL 549
Query: 546 ----EESVVENTLRPCLVELSEDPDVDVRFFASQALQSSD 581
+ +V E + P L +L++D D DV++FA+QAL+ ++
Sbjct: 550 AAGGDSTVYEQQIIPLLEQLTKDNDPDVQYFATQALEQTN 589
>2AAA_CAEEL (Q09543) Probable protein phosphatase PP2A regulatory
subunit (Protein phosphatase PP2A regulatory subunit A)
Length = 590
Score = 545 bits (1405), Expect = e-154
Identities = 288/579 (49%), Positives = 391/579 (66%), Gaps = 4/579 (0%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENNDDDDEVL 64
D LYPIAVLIDEL+NED+ LRLNSIR+LSTIA ALG ERTR ELI FL++ D+DEVL
Sbjct: 9 DDALYPIAVLIDELRNEDVTLRLNSIRKLSTIALALGVERTRNELIQFLTDTIYDEDEVL 68
Query: 65 LAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLVE 124
L +AE+LG F P VGG +H + LL PLE L TVEET VRDK+VESL +I + L E
Sbjct: 69 LVLAEQLGNFTPLVGGPDHVHCLLLPLENLATVEETVVRDKAVESLRKIADKHSSASLEE 128
Query: 125 HFIPLVKRLAAGEWFTARVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQDDMPMVRRSAA 184
HF+P+++RLA G+WFT+R S+CGLF + YP A K+EL++M+ LC+DD PMVRR+AA
Sbjct: 129 HFVPMLRRLATGDWFTSRTSACGLFSVVYPRVSPAIKSELKSMFRTLCRDDTPMVRRAAA 188
Query: 185 TNLGKFAATVEAAHLKSDIMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILP 244
LG+FA E + + S DL D+QDSVRLL VE A G LL+ I P
Sbjct: 189 AKLGEFAKVFEKTAVIEGLHSSLTDLHVDEQDSVRLLTVESAIAFGTLLDKANKKKLIEP 248
Query: 245 VIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKV 304
+++ DKSWRVRYMVA +L E+ +G + T LV Y LL+D E EVR AA ++
Sbjct: 249 ILIELFDDKSWRVRYMVAEKLIEIQNVLGEDMDTTHLVNMYTNLLKDPEGEVRCAATQRL 308
Query: 305 TKFSRILSPE----LAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLL 360
+F+ L + + +L KEL D +Q V+S LA VIMG+AP++GK+ T+ +LL
Sbjct: 309 QEFALNLPEDKRQNIICNSLLNVAKELVTDGNQLVKSELAGVIMGLAPLIGKEQTVSELL 368
Query: 361 PIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEY 420
PI++ LL D+ P+VRLNIIS LD+VN+VIG LS SLLPAIV LAED WRVRLAI+++
Sbjct: 369 PIYMQLLNDQTPEVRLNIISSLDKVNEVIGAAQLSTSLLPAIVGLAEDGKWRVRLAIVQF 428
Query: 421 IPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQV 480
+PLLASQLG FFD+KL LC+ WL D V+SIR+A+ +K L ++FG WA +I+P++
Sbjct: 429 MPLLASQLGQEFFDEKLLPLCLNWLTDHVFSIREASTLIMKELTQKFGGQWASTNIVPKM 488
Query: 481 LDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQS 540
+ D +YL RMT L ++ L+ + E +++P+V + +D VPN++FN AK L+
Sbjct: 489 QKLQKDTNYLQRMTCLFCLNTLSEAMTQEQILKEIMPIVKDLVEDDVPNVRFNAAKSLKR 548
Query: 541 LIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQALQS 579
+ + S + + ++P L +L +D D DVR+F+ +A S
Sbjct: 549 IGKNLTPSTLTSEVKPLLEKLGKDSDFDVRYFSEEAKNS 587
Score = 68.9 bits (167), Expect = 3e-11
Identities = 78/386 (20%), Positives = 158/386 (40%), Gaps = 9/386 (2%)
Query: 203 IMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQDKSWRVRYMVA 262
I + D+L +D ++RL ++ + + L + ++ + + D+ V ++A
Sbjct: 15 IAVLIDELRNEDV-TLRLNSIRKLSTIALALGVERTRNELIQFLTDTIYDED-EVLLVLA 72
Query: 263 NQLYELCEAVG-PEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILSPELAIEHIL 321
QL VG P+ L+P L E VR A + K + S EH +
Sbjct: 73 EQLGNFTPLVGGPDHVHCLLLPLE-NLATVEETVVRDKAVESLRKIADKHSSASLEEHFV 131
Query: 322 PCVKELSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISK 381
P ++ L+ R++ + + P + A +L +F +L +D+ P VR +K
Sbjct: 132 PMLRRLATGDWFTSRTSACGLFSVVYPRVSP-AIKSELKSMFRTLCRDDTPMVRRAAAAK 190
Query: 382 LDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALC 441
L + +V + + L ++ +L D VRL +E + L + +
Sbjct: 191 LGEFAKVFEKTAVIEGLHSSLTDLHVDEQDSVRLLTVESAIAFGTLLDKANKKKLIEPIL 250
Query: 442 MQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAISL 501
++ DK + +R A + + G D H++ +++ DP R Q +
Sbjct: 251 IELFDDKSWRVRYMVAEKLIEIQNVLGEDMDTTHLVNMYTNLLKDPEGEVRCAATQRLQE 310
Query: 502 LAPVLGSEITSSKLLPLVVNASKDRVPN----IKFNVAKVLQSLIPIVEESVVENTLRPC 557
A L + + + ++N +K+ V + +K +A V+ L P++ + + L P
Sbjct: 311 FALNLPEDKRQNIICNSLLNVAKELVTDGNQLVKSELAGVIMGLAPLIGKEQTVSELLPI 370
Query: 558 LVELSEDPDVDVRFFASQALQSSDQV 583
++L D +VR +L ++V
Sbjct: 371 YMQLLNDQTPEVRLNIISSLDKVNEV 396
>2AAA_YEAST (P31383) Protein phosphatase PP2A regulatory subunit A
(PR65)
Length = 635
Score = 479 bits (1233), Expect = e-135
Identities = 263/600 (43%), Positives = 390/600 (64%), Gaps = 21/600 (3%)
Query: 5 DQPLYPIAVLIDELKNEDIQLRLNSIRRLSTIARALGEERTRKELIPFLSE-NNDDDDEV 63
++ LYP+A+L+DELK++DI R+ ++++L TIA ALG ERTR ELIPFL+E DD+DEV
Sbjct: 33 NESLYPLALLMDELKHDDIANRVEAMKKLDTIALALGPERTRNELIPFLTEVAQDDEDEV 92
Query: 64 LLAMAEELGVFIPYVGGVEHANVLLPPLETLCTVEETCVRDKSVESLCRIGAQMREQDLV 123
+AE+LG F+PY+GG ++A +LLP LE L + EET VR+K+V+SL + ++ ++ L
Sbjct: 93 FAVLAEQLGKFVPYIGGPQYATILLPVLEILASAEETLVREKAVDSLNNVAQELSQEQLF 152
Query: 124 EHFIPLVKRLAAGEWFTARVSSCGLFH-IAYPSAPEAQKAELRAMYGQLCQDDMPMVRRS 182
F+PL++ LA +WF+++VS+CGLF + ++ + + A+Y QL QDD PMV+R+
Sbjct: 153 SDFVPLIEHLATADWFSSKVSACGLFKSVIVRIKDDSLRKNILALYLQLAQDDTPMVKRA 212
Query: 183 AATNLGKFAATV-EAAHLKSD-----IMSVFDDLTQDDQDSVRLLAVEGCAALGKLLEPQ 236
NL + + L +D I ++F + D+QDSV+ LAV+ ++ K +
Sbjct: 213 VGKNLPILIDLLTQNLGLSTDEDWDYISNIFQKIINDNQDSVKFLAVDCLISILKFFNAK 272
Query: 237 ECVAH---ILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRT-ELVPAYVRLLRDN 292
+H +L V D++WRVRYM A++ +L ELV ++ L DN
Sbjct: 273 GDESHTQDLLNSAVKLIGDEAWRVRYMAADRFSDLASQFSSNQAYIDELVQPFLNLCEDN 332
Query: 293 EAEVRIAAAGKVTKFSRILS-PELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLG 351
E +VR A A +V+ F++ L+ P + + ILP V+ LS D S+ VRSALAS I + +L
Sbjct: 333 EGDVREAVAKQVSGFAKFLNDPSIILNKILPAVQNLSMDESETVRSALASKITNIVLLLN 392
Query: 352 KDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHW 411
KD I LPI L++L+DEFPDVRLNII+ L VN VIGI+LLS SLLPAI ELA+D +W
Sbjct: 393 KDQVINNFLPILLNMLRDEFPDVRLNIIASLKVVNDVIGIELLSDSLLPAITELAKDVNW 452
Query: 412 RVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDW 471
RVR+AIIEYIP+LA QLG+ FFD +L LC+ WL D VYSIR+AA NN+KRL E FG DW
Sbjct: 453 RVRMAIIEYIPILAEQLGMQFFDQQLSDLCLSWLWDTVYSIREAAVNNLKRLTEIFGSDW 512
Query: 472 AMQHIIPQVL--DMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNASKDRVPN 529
II ++L D+ +++ R TIL A++ L PV+ ++ + +LLP + + + D VPN
Sbjct: 513 CRDEIISRLLKFDLQLLENFVSRFTILSALTTLVPVVSLDVVTEQLLPFISHLADDGVPN 572
Query: 530 IKFNVAKVLQSLIPIV------EESVVENTLRPCLVELSEDPDVDVRFFASQALQSSDQV 583
I+FNVAK ++ ++ +++++NT+ P L L +D DVDV++FA ++L ++
Sbjct: 573 IRFNVAKSYAVIVKVLIKDEAKYDALIKNTILPSLQTLFQDEDVDVKYFAKKSLAECQEL 632
>P4R1_RAT (Q8VI02) Serine/threonine phosphatase 4 regulatory subunit
1
Length = 951
Score = 73.6 bits (179), Expect = 1e-12
Identities = 71/269 (26%), Positives = 120/269 (44%), Gaps = 18/269 (6%)
Query: 323 CVKE----LSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNI 378
C++E L++D VR LA I +A +LG T L+PIF LKD +VR+ +
Sbjct: 664 CLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGV 722
Query: 379 ISKLDQVNQVIGIDLLSQSL--LPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDK 436
+ L +++ ID + L L + R+WR R + E + LL D
Sbjct: 723 LKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDY 782
Query: 437 LGALCMQWLKDKVYSIR----DAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYR 492
L + + DKV S+R + VK+L P + ++ I V + P + R
Sbjct: 783 LRPIALNLCADKVSSVRWISYKLVSEMVKKLHMATPPTFGVELINELVENFGRCPKWSGR 842
Query: 493 MTILQAISLLA--PVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVL-QSLIP----IV 545
+ + L + + L+P ++ + DRVPN++ +AK L Q+L+ +
Sbjct: 843 QAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKEYFLA 902
Query: 546 EESVVENTLRPCLVELSEDPDVDVRFFAS 574
S + + ++ L D D DV++FAS
Sbjct: 903 SASCHQEAVEQTIMALQMDRDSDVKYFAS 931
Score = 62.4 bits (150), Expect = 3e-09
Identities = 62/233 (26%), Positives = 101/233 (42%), Gaps = 11/233 (4%)
Query: 234 EPQECVAHILPVIVNFSQDKSWRVRYMVANQLYEL---CEAVGPE---PTRTELVPAYVR 287
E ++C+A +L I + D VR + Q+ + C+ P L+P VR
Sbjct: 80 EERDCIA-VLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKYLLPIVVR 138
Query: 288 LLRDNEAEVR-IAAAGKVTKFSRILSPELAIE-HILPCVKELSA-DSSQHVRSALASVIM 344
L D +VR + A + + L L +E + P + +L+A DS+ V++ +++
Sbjct: 139 YLADQNNQVRKTSQAALLALLEQELIERLDVETKVCPVLIDLTAPDSNDDVKTEAVAIMC 198
Query: 345 GMAPVLGKDATIEQLLPIFLSLLKD-EFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIV 403
MAP++GKD T +LP F + D VR + + V+G + LLP
Sbjct: 199 KMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFF 258
Query: 404 ELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAA 456
+L D W VR A E ++ KL AL + + D +R AA
Sbjct: 259 QLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAA 311
Score = 48.9 bits (115), Expect = 4e-05
Identities = 35/128 (27%), Positives = 64/128 (49%), Gaps = 3/128 (2%)
Query: 250 SQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSR 309
+ D W+VR +A ++EL +G + T +LVP + L+D + EVRI + F +
Sbjct: 673 ASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLD-EVRIGVLKHLHDFLK 731
Query: 310 ILSPELAIEHILPCVKELSADSSQH--VRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+L + E++ + L D+S++ R+ LA ++ + + + L PI L+L
Sbjct: 732 LLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLC 791
Query: 368 KDEFPDVR 375
D+ VR
Sbjct: 792 ADKVSSVR 799
Score = 33.9 bits (76), Expect = 1.2
Identities = 50/247 (20%), Positives = 93/247 (37%), Gaps = 10/247 (4%)
Query: 341 SVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQV------NQVIGIDLL 394
S++ + V G++ +L L D P VR ++ ++ + N+
Sbjct: 69 SLLDTLREVCGEERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAF 128
Query: 395 SQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGA---LCMQWLKDKVYS 451
S+ LLP +V D++ +VR + L Q + D + L D
Sbjct: 129 SKYLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERLDVETKVCPVLIDLTAPDSNDD 188
Query: 452 IRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQA-ISLLAPVLGSEI 510
++ A + ++A G D + I+P+ +M D + + A + V+G +
Sbjct: 189 VKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQA 248
Query: 511 TSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVR 570
T LLP D V ++ A+ ++ + + L + L DP VR
Sbjct: 249 TEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVR 308
Query: 571 FFASQAL 577
A Q+L
Sbjct: 309 QAAFQSL 315
>P4R1_MOUSE (Q8K2V1) Serine/threonine phosphatase 4 regulatory
subunit 1
Length = 951
Score = 73.2 bits (178), Expect = 2e-12
Identities = 71/269 (26%), Positives = 119/269 (43%), Gaps = 18/269 (6%)
Query: 323 CVKE----LSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNI 378
C++E L++D VR LA I +A +LG T L+PIF LKD +VR+ +
Sbjct: 664 CLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGV 722
Query: 379 ISKLDQVNQVIGIDLLSQSL--LPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDK 436
+ L +++ ID + L L + R+WR R + E + LL D
Sbjct: 723 LKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDY 782
Query: 437 LGALCMQWLKDKVYSIR----DAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYR 492
L + + DKV S+R + VK+L P + + I V + P + R
Sbjct: 783 LRPIALNLCADKVSSVRWISYKLVSEMVKKLHTATPPTFGVDLINELVENFGRCPKWSGR 842
Query: 493 MTILQAISLLA--PVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVL-QSLIP----IV 545
+ + L + + L+P ++ + DRVPN++ +AK L Q+L+ +
Sbjct: 843 QAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKEYFLA 902
Query: 546 EESVVENTLRPCLVELSEDPDVDVRFFAS 574
S + + ++ L D D DV++FAS
Sbjct: 903 SASCHQEAVEQTIMALQMDRDSDVKYFAS 931
Score = 59.7 bits (143), Expect = 2e-08
Identities = 60/233 (25%), Positives = 100/233 (42%), Gaps = 11/233 (4%)
Query: 234 EPQECVAHILPVIVNFSQDKSWRVRYMVANQLYEL---CEAVGPE---PTRTELVPAYVR 287
+ ++C+A +L I + D VR + Q+ + C+ P L+P VR
Sbjct: 80 DERDCIA-VLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKYLLPIVVR 138
Query: 288 LLRDNEAEVR-IAAAGKVTKFSRILSPELAIE-HILPCVKELSA-DSSQHVRSALASVIM 344
L D +VR + A + + L +E + P + +L+A DS+ V++ +++
Sbjct: 139 YLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIDLTAPDSNDDVKTEAVAIMC 198
Query: 345 GMAPVLGKDATIEQLLPIFLSLLKD-EFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIV 403
MAP++GKD T +LP F + D VR + + V+G + LLP
Sbjct: 199 KMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFF 258
Query: 404 ELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAA 456
+L D W VR A E ++ KL AL + + D +R AA
Sbjct: 259 QLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAA 311
Score = 49.7 bits (117), Expect = 2e-05
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 11/157 (7%)
Query: 250 SQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSR 309
+ D W+VR +A ++EL +G + T +LVP + L+D + EVRI + F +
Sbjct: 673 ASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLD-EVRIGVLKHLHDFLK 731
Query: 310 ILSPELAIEHILPCVKELSADSSQH--VRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+L + E++ + L D+S++ R+ LA ++ + + + L PI L+L
Sbjct: 732 LLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLC 791
Query: 368 KDEFPDVR-------LNIISKLDQVN-QVIGIDLLSQ 396
D+ VR ++ KL G+DL+++
Sbjct: 792 ADKVSSVRWISYKLVSEMVKKLHTATPPTFGVDLINE 828
Score = 34.3 bits (77), Expect = 0.93
Identities = 47/222 (21%), Positives = 84/222 (37%), Gaps = 10/222 (4%)
Query: 366 LLKDEFPDVRLNIISKLDQV------NQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIE 419
L D P VR ++ ++ + N+ S+ LLP +V D++ +VR
Sbjct: 94 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKYLLPIVVRYLADQNNQVRKTSQA 153
Query: 420 YIPLLASQLGVGFFDDKLGA---LCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHI 476
+ L Q + FD + L D ++ A + ++A G D + I
Sbjct: 154 ALLALLEQELIERFDVETKVCPVLIDLTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 213
Query: 477 IPQVLDMINDPHYLYRMTILQA-ISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVA 535
+P+ +M D + + A + V+G + T LLP D V ++ A
Sbjct: 214 LPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACA 273
Query: 536 KVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ ++ + + L + L DP VR A Q+L
Sbjct: 274 ECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSL 315
>P4R1_HUMAN (Q8TF05) Serine/threonine phosphatase 4 regulatory
subunit 1
Length = 950
Score = 73.2 bits (178), Expect = 2e-12
Identities = 71/269 (26%), Positives = 119/269 (43%), Gaps = 18/269 (6%)
Query: 323 CVKE----LSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNI 378
C++E L++D VR LA I +A +LG T L+PIF LKD +VR+ +
Sbjct: 663 CLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGV 721
Query: 379 ISKLDQVNQVIGIDLLSQSL--LPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDK 436
+ L +++ ID + L L + R+WR R + E + LL D
Sbjct: 722 LKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDY 781
Query: 437 LGALCMQWLKDKVYSIR----DAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYR 492
L + + DKV S+R + VK+L P + + I V + P + R
Sbjct: 782 LRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGR 841
Query: 493 MTILQAISLLA--PVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVL-QSLIP----IV 545
+ + L + + L+P ++ + DRVPN++ +AK L Q+L+ +
Sbjct: 842 QAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLA 901
Query: 546 EESVVENTLRPCLVELSEDPDVDVRFFAS 574
S + + ++ L D D DV++FAS
Sbjct: 902 SASCHQEAVEQTIMALQMDRDSDVKYFAS 930
Score = 60.5 bits (145), Expect = 1e-08
Identities = 61/233 (26%), Positives = 100/233 (42%), Gaps = 11/233 (4%)
Query: 234 EPQECVAHILPVIVNFSQDKSWRVRYMVANQLYEL---CEAVGPE---PTRTELVPAYVR 287
+ ++C+A +L I + D VR + Q+ + C+ P L+P VR
Sbjct: 80 DERDCIA-VLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVR 138
Query: 288 LLRDNEAEVR-IAAAGKVTKFSRILSPELAIE-HILPCVKELSA-DSSQHVRSALASVIM 344
L D +VR + A + + L +E + P + EL+A DS+ V++ +++
Sbjct: 139 YLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMC 198
Query: 345 GMAPVLGKDATIEQLLPIFLSLLKD-EFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIV 403
MAP++GKD T +LP F + D VR + + V+G + LLP
Sbjct: 199 KMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFF 258
Query: 404 ELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAA 456
+L D W VR A E ++ KL AL + + D +R AA
Sbjct: 259 QLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAA 311
Score = 49.7 bits (117), Expect = 2e-05
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 11/157 (7%)
Query: 250 SQDKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEAEVRIAAAGKVTKFSR 309
+ D W+VR +A ++EL +G + T +LVP + L+D + EVRI + F +
Sbjct: 672 ASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLD-EVRIGVLKHLHDFLK 730
Query: 310 ILSPELAIEHILPCVKELSADSSQH--VRSALASVIMGMAPVLGKDATIEQLLPIFLSLL 367
+L + E++ + L D+S++ R+ LA ++ + + + L PI L+L
Sbjct: 731 LLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLC 790
Query: 368 KDEFPDVR-------LNIISKLDQVN-QVIGIDLLSQ 396
D+ VR ++ KL G+DL+++
Sbjct: 791 ADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINE 827
Score = 34.7 bits (78), Expect = 0.71
Identities = 47/222 (21%), Positives = 84/222 (37%), Gaps = 10/222 (4%)
Query: 366 LLKDEFPDVRLNIISKLDQV------NQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIE 419
L D P VR ++ ++ + N+ S+ LLP +V D++ +VR
Sbjct: 94 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA 153
Query: 420 YIPLLASQLGVGFFDDKLGA---LCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHI 476
+ L Q + FD + L D ++ A + ++A G D + I
Sbjct: 154 ALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 213
Query: 477 IPQVLDMINDPHYLYRMTILQA-ISLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVA 535
+P+ +M D + + A + V+G + T LLP D V ++ A
Sbjct: 214 LPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACA 273
Query: 536 KVLQSLIPIVEESVVENTLRPCLVELSEDPDVDVRFFASQAL 577
+ ++ + + L + L DP VR A Q+L
Sbjct: 274 ECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSL 315
>PP4L_HUMAN (Q9P1A2) Serine/threonine phosphatase 4 regulatory
subunit 1-like (PRO1085)
Length = 438
Score = 64.7 bits (156), Expect = 6e-10
Identities = 66/271 (24%), Positives = 120/271 (43%), Gaps = 22/271 (8%)
Query: 323 CVKE----LSADSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNI 378
C+K+ L++D VR ALA I +A +LG T L+PIF LKD +VR+ +
Sbjct: 153 CLKDTYETLASDVQWKVRRALAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGV 211
Query: 379 ISKLDQVNQVIGIDLLSQSL--LPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDK 436
+ L +++ D L L V R+WR R + E + L+ D
Sbjct: 212 LRHLYDFLKLLHEDKRRDYLYQLQEFVVTDNSRNWRFRYELAEQLILILELYSPNDVYDY 271
Query: 437 LGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTIL 496
L + ++ D+V +R + V + ++F + + + ++I + +
Sbjct: 272 LMHIALKLCADQVSEVRWISFKLVVAILQKFYSNSESALGLNFINELIIRFRHCSKWVGR 331
Query: 497 QAISLLAPVLGS------EITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVV 550
QA + + + S + LLP +++ + D VPN++ +AK L+ + ++E++
Sbjct: 332 QAFAFICQAVVSKECVPVDQFMEHLLPSLLSLASDPVPNVRVLLAKALRQM--LLEKAYF 389
Query: 551 ENTLRP-------CLVELSEDPDVDVRFFAS 574
N P ++ L D D DV FFA+
Sbjct: 390 RNAGNPHLEVIEETILALQSDRDQDVSFFAA 420
>S3B1_SCHPO (Q10178) U2 snRNP component prp10
Length = 1188
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/357 (19%), Positives = 152/357 (42%), Gaps = 32/357 (8%)
Query: 242 ILPVIVNFSQDKSWRVRYMVANQLYELCEAVG----PEPTRTELVPAYVRLLRDNEAEVR 297
I+ +VN +D+S R M A + ++ ++G E L+ + ++ E +
Sbjct: 733 IVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEK 792
Query: 298 IAAAGKVTKFSRILSP-----ELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVL-- 350
+ +T FS +++ + + I+ + + S +VR A ++ + VL
Sbjct: 793 VI----LTCFSTVVNALGTRCKPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKA 848
Query: 351 -GKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLS---QSLLPAIVELA 406
G++A + +L + L +E+P+V +I+ + + V+G+ + + LLP + +
Sbjct: 849 CGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPIL 908
Query: 407 EDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQ---WLKDKVYSIRDAAANNVKRL 463
+RH +V+ I+ + +A + + +C + LK SIR AA N +
Sbjct: 909 RNRHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYI 968
Query: 464 AEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAISLLAPVLGSEITSSKLLPLVVNAS 523
++ GP Q ++ +L+ + R+ AI+++A ++P ++
Sbjct: 969 SKAIGP----QDVLATLLNNLKVQERQNRVCTTVAIAIVA----ETCMPFTVVPALMADY 1020
Query: 524 KDRVPNIKFNVAKVLQSLIPIVEESVVE--NTLRPCLVELSEDPDVDVRFFASQALQ 578
+ N++ V K L + + E + + P L + D D R A+ ++
Sbjct: 1021 RTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIK 1077
>GCN1_YEAST (P33892) Translational activator GCN1
Length = 2672
Score = 44.7 bits (104), Expect = 7e-04
Identities = 56/253 (22%), Positives = 112/253 (44%), Gaps = 46/253 (18%)
Query: 239 VAHILPVIVNFSQDKSWRVR----YMVANQLYELCEAVGPEPTRTELVPAYVRLLRDNEA 294
V ++PV V+ + +WR + ++ N Y + + + +VP V +L D+
Sbjct: 1445 VKKLIPVAVSNLDEIAWRTKRGSVQLLGNMAY--LDPTQLSASLSTIVPEIVGVLNDSHK 1502
Query: 295 EVRIAAAGKVTKFSRIL-SPELAIEHILPCVKELSADSSQHVRSALASVIMGMAPVLGKD 353
EVR AA + +F ++ +PE I+ ++P + + D +++ AL S+I
Sbjct: 1503 EVRKAADESLKRFGEVIRNPE--IQKLVPVLLQAIGDPTKYTEEALDSLIQTQFVHYIDG 1560
Query: 354 ATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRV 413
+ L + + ++ D NI K ++ + I + ++ L+P + +L ++ V
Sbjct: 1561 PS----LALIIHIIHRGMHDRSANIKRKACKIVGNMAILVDTKDLIPYLQQLIDE----V 1612
Query: 414 RLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAM 473
+A+++ +P + LGAL V+RL EE PD
Sbjct: 1613 EIAMVDPVPNTRATAA-----RALGAL-------------------VERLGEEQFPD--- 1645
Query: 474 QHIIPQVLDMIND 486
+IP++LD ++D
Sbjct: 1646 --LIPRLLDTLSD 1656
Score = 38.1 bits (87), Expect = 0.065
Identities = 68/295 (23%), Positives = 115/295 (38%), Gaps = 28/295 (9%)
Query: 142 RVSSCGLFHIAYPSAPEAQKAELRAMYGQLCQ---DDMPMVRRSAATNLGKFAATVEAAH 198
R ++ ++ P+ P A K L + G + ++R AA LG V
Sbjct: 1846 RATTVDIWKALVPNTPRAVKEILPTLTGMIVTHLASSSNVLRNIAAQTLGDLVRRVGGNA 1905
Query: 199 LKSDIMSVFDDLTQDDQDSVRLLAVEG-CAALGKLLEPQ--ECVAHILPVIVNFSQ---- 251
L + S+ + L + R +G C AL +L+E E ++ IVN +
Sbjct: 1906 LSQLLPSLEESLIETSNSDSR----QGVCIALYELIESASTETISQFQSTIVNIIRTALI 1961
Query: 252 DKSWRVRYMVANQLYELCEAVGPEPTRTELVPAYVRLLR--DNEAEVRIAAAGKVTKFSR 309
D+S VR A + VG E++P + +L DN + ++K S
Sbjct: 1962 DESATVREAAALSFDVFQDVVGKTAV-DEVLPYLLHMLESSDNSDFALLGLQEIMSKKSD 2020
Query: 310 ILSPELAIEHILPCVKELSADSSQHVRSALASV--IMGMAPVLGKDATIEQLLPIFLSLL 367
++ P L + P + A SAL S+ + G A I L+ +
Sbjct: 2021 VIFPILIPTLLAPPIDAFRA-------SALGSLAEVAGSALYKRLSIIINALVDAIIGTS 2073
Query: 368 KDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIP 422
+DE L + LD+V + D LL I+ L + + R+A++E +P
Sbjct: 2074 EDESTKGALELA--LDRVFLSVNDDEGLHPLLQQIMSLLKSDNIEKRIAVLERLP 2126
>S3B1_XENLA (O57683) Splicing factor 3B subunit 1 (Spliceosome
associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA
splicing factor SF3b 155 kDa subunit) (146 kDa nuclear
protein)
Length = 1307
Score = 44.3 bits (103), Expect = 0.001
Identities = 59/261 (22%), Positives = 114/261 (43%), Gaps = 21/261 (8%)
Query: 330 DSSQHVRSALASVIMGMAPVLGKDATIEQLLP----IFLSLLKDEFPDVRLNIISKLDQV 385
+ S VR A +I A V+ K E+L+ + L +E+P+V +I+ L +
Sbjct: 945 NKSAKVRQQAADLISRTAVVM-KTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAI 1003
Query: 386 NQVIGIDLLS---QSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALC- 441
VIG+ ++ + LLP + + ++RH +V+ I+ + +A + + +C
Sbjct: 1004 VNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICF 1063
Query: 442 --MQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAI 499
++ LK +IR A N +A+ GP ++ +L+ + R+ AI
Sbjct: 1064 ELLELLKAHKKAIRRATVNTFGYIAKAIGP----HDVLATLLNNLKVQERQNRVCTTVAI 1119
Query: 500 SLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVVE--NTLRPC 557
+++A + +LP ++N + N++ V K L L + E + + P
Sbjct: 1120 AIVA----ETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPL 1175
Query: 558 LVELSEDPDVDVRFFASQALQ 578
L + D D+ R AS +Q
Sbjct: 1176 LEDALMDRDLVHRQTASAVVQ 1196
>S3B1_MOUSE (Q99NB9) Splicing factor 3B subunit 1 (Spliceosome
associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA
splicing factor SF3b 155 kDa subunit)
Length = 1304
Score = 44.3 bits (103), Expect = 0.001
Identities = 59/261 (22%), Positives = 114/261 (43%), Gaps = 21/261 (8%)
Query: 330 DSSQHVRSALASVIMGMAPVLGKDATIEQLLP----IFLSLLKDEFPDVRLNIISKLDQV 385
+ S VR A +I A V+ K E+L+ + L +E+P+V +I+ L +
Sbjct: 942 NKSAKVRQQAADLISRTAVVM-KTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAI 1000
Query: 386 NQVIGIDLLS---QSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALC- 441
VIG+ ++ + LLP + + ++RH +V+ I+ + +A + + +C
Sbjct: 1001 VNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICF 1060
Query: 442 --MQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAI 499
++ LK +IR A N +A+ GP ++ +L+ + R+ AI
Sbjct: 1061 ELLELLKAHKKAIRRATVNTFGYIAKAIGP----HDVLATLLNNLKVQERQNRVCTTVAI 1116
Query: 500 SLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVVE--NTLRPC 557
+++A + +LP ++N + N++ V K L L + E + + P
Sbjct: 1117 AIVA----ETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPL 1172
Query: 558 LVELSEDPDVDVRFFASQALQ 578
L + D D+ R AS +Q
Sbjct: 1173 LEDALMDRDLVHRQTASAVVQ 1193
>S3B1_HUMAN (O75533) Splicing factor 3B subunit 1 (Spliceosome
associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA
splicing factor SF3b 155 kDa subunit)
Length = 1304
Score = 44.3 bits (103), Expect = 0.001
Identities = 59/261 (22%), Positives = 114/261 (43%), Gaps = 21/261 (8%)
Query: 330 DSSQHVRSALASVIMGMAPVLGKDATIEQLLP----IFLSLLKDEFPDVRLNIISKLDQV 385
+ S VR A +I A V+ K E+L+ + L +E+P+V +I+ L +
Sbjct: 942 NKSAKVRQQAADLISRTAVVM-KTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAI 1000
Query: 386 NQVIGIDLLS---QSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALC- 441
VIG+ ++ + LLP + + ++RH +V+ I+ + +A + + +C
Sbjct: 1001 VNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICF 1060
Query: 442 --MQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIIPQVLDMINDPHYLYRMTILQAI 499
++ LK +IR A N +A+ GP ++ +L+ + R+ AI
Sbjct: 1061 ELLELLKAHKKAIRRATVNTFGYIAKAIGP----HDVLATLLNNLKVQERQNRVCTTVAI 1116
Query: 500 SLLAPVLGSEITSSKLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVEESVVE--NTLRPC 557
+++A + +LP ++N + N++ V K L L + E + + P
Sbjct: 1117 AIVA----ETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPL 1172
Query: 558 LVELSEDPDVDVRFFASQALQ 578
L + D D+ R AS +Q
Sbjct: 1173 LEDALMDRDLVHRQTASAVVQ 1193
>IMB1_HUMAN (Q14974) Importin beta-1 subunit (Karyopherin beta-1
subunit) (Nuclear factor P97) (Importin 90)
Length = 876
Score = 43.5 bits (101), Expect = 0.002
Identities = 48/184 (26%), Positives = 75/184 (40%), Gaps = 24/184 (13%)
Query: 168 YGQLCQDDMPM-VRRSAATNLGKFAATVEAAHLKSDIMSVFDDLTQ---------DDQDS 217
+ +C ++M + + S A G+ + K + + LTQ DD D
Sbjct: 283 WSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDW 342
Query: 218 VRLLAVEGCAALGKLLEPQECVAHILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPEPT 277
A C L + V H+LP I ++ W RY A + C GPEP+
Sbjct: 343 NPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDW--RYRDAAVMAFGCILEGPEPS 400
Query: 278 R-----TELVPAYVRLLRDNEAEVRIAAAGKVTKFSRILSPELAIEHI-----LPCVKE- 326
+ + +P + L++D VR AA V + +L PE AI + L C+ E
Sbjct: 401 QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELL-PEAAINDVYLAPLLQCLIEG 459
Query: 327 LSAD 330
LSA+
Sbjct: 460 LSAE 463
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.136 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,565,101
Number of Sequences: 164201
Number of extensions: 2508683
Number of successful extensions: 7661
Number of sequences better than 10.0: 51
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 7224
Number of HSP's gapped (non-prelim): 152
length of query: 587
length of database: 59,974,054
effective HSP length: 116
effective length of query: 471
effective length of database: 40,926,738
effective search space: 19276493598
effective search space used: 19276493598
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Lotus: description of TM0310b.14