BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0283.14
         (461 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

GTR8_RAT (Q9JJZ1) Solute carrier family 2, facilitated glucose t...   276  1e-73
GTR8_MOUSE (Q9JIF3) Solute carrier family 2, facilitated glucose...   271  3e-72
GTR8_HUMAN (Q9NY64) Solute carrier family 2, facilitated glucose...   263  7e-70
GTR6_HUMAN (Q9UGQ3) Solute carrier family 2, facilitated glucose...   223  8e-58
GTR3_RAT (Q07647) Solute carrier family 2, facilitated glucose t...   204  5e-52
GTR3_MOUSE (P32037) Solute carrier family 2, facilitated glucose...   202  1e-51
ITR2_YEAST (P30606) Myo-inositol transporter 2                        199  2e-50
GTR2_HUMAN (P11168) Solute carrier family 2, facilitated glucose...   198  3e-50
GTR3_HUMAN (P11169) Solute carrier family 2, facilitated glucose...   197  4e-50
CSBC_BACSU (P46333) Probable metabolite transport protein csbC        197  6e-50
XYLT_LACBR (O52733) D-xylose-proton symporter (D-xylose transpor...   196  1e-49
GALP_ECOLI (P37021) Galactose-proton symporter (Galactose transp...   195  2e-49
GTR3_SHEEP (P47843) Solute carrier family 2, facilitated glucose...   194  3e-49
ARAE_BACSU (P96710) Arabinose-proton symporter (Arabinose transp...   194  3e-49
GTR4_MOUSE (P14142) Solute carrier family 2, facilitated glucose...   194  4e-49
GTR3_CHICK (P28568) Solute carrier family 2, facilitated glucose...   194  4e-49
GTR4_HUMAN (P14672) Solute carrier family 2, facilitated glucose...   193  7e-49
GTR3_BOVIN (P58352) Solute carrier family 2, facilitated glucose...   193  7e-49
GTR4_RAT (P19357) Solute carrier family 2, facilitated glucose t...   192  1e-48
GTR3_CANFA (P47842) Solute carrier family 2, facilitated glucose...   192  1e-48

>GTR8_RAT (Q9JJZ1) Solute carrier family 2, facilitated glucose
           transporter, member 8 (Glucose transporter type 8)
           (Glucose transporter type X1)
          Length = 478

 Score =  276 bits (705), Expect = 1e-73
 Identities = 173/452 (38%), Positives = 248/452 (54%), Gaps = 24/452 (5%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRD----LNLSISRFSLFGSLSNVGAMVGAT 85
           V L     ALGP+ FGF  GYSSP    + R     L L  +  S FG++  +GA  G  
Sbjct: 26  VFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGV 85

Query: 86  VSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYI 145
           + G L +  GRK SLL+  VP + G+  I+ A+D  +L  GRLL G   G+ S V PVYI
Sbjct: 86  LGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYI 145

Query: 146 AEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFNWRTLALLGVFPCAILIPGLYFIPES 205
           +EI    +RG LG+  QL V  GI+LAY+ G    WR LA+LG  P  +++  + ++PE+
Sbjct: 146 SEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPET 205

Query: 206 PRWLAEMGLMERFESSLQTLRGSN---VDITMEAQEIQNRFYTVCRPQEEKILVSFDGIG 262
           PR+L      +   ++L+ L GS     +  + A+    +   + RP   K L+   GI 
Sbjct: 206 PRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLII--GIC 263

Query: 263 LLVLQQLSGINGVFFYASKIFASAGISSSDAATFGLGAIQVVMTGVATWLVDKSGRRILL 322
           L+V QQLSG+N + FYA+ IF  A    S  A+  +G IQV+ T VA  ++D++GR++LL
Sbjct: 264 LMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLL 323

Query: 323 IVSSSIMTISLLLVASAF--------------YLEGVVSKGSELHNILGILSVVGLVALI 368
            +S  IM  S+    + F               L  + ++ +++H  L  L+V  +   I
Sbjct: 324 ALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFI 383

Query: 369 IGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTANFLLN-WSSAGTFT 427
            GFA+G GPIPWL+MSEI P +IKG+A  V   +NWF A ++T   N ++      G F 
Sbjct: 384 AGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFW 443

Query: 428 IYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
           + A F   +V F L FVPETK RTLE+I A F
Sbjct: 444 LTAAFCILSVLFTLTFVPETKGRTLEQITAHF 475


>GTR8_MOUSE (Q9JIF3) Solute carrier family 2, facilitated glucose
           transporter, member 8 (Glucose transporter type 8)
           (Glucose transporter type X1)
          Length = 477

 Score =  271 bits (693), Expect = 3e-72
 Identities = 172/451 (38%), Positives = 248/451 (54%), Gaps = 23/451 (5%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRD----LNLSISRFSLFGSLSNVGAMVGAT 85
           V L     ALGP+ FGF  GYSSP    + R     L L  +  S FG++  +GA  G  
Sbjct: 26  VFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGI 85

Query: 86  VSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYI 145
           + G L +  GRK SLL+  VP + G+  I+ A+D  +L  GRLL G   G+ S V PVYI
Sbjct: 86  LGGWLLDRSGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYI 145

Query: 146 AEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFNWRTLALLGVFPCAILIPGLYFIPES 205
           +EI    +RG LG+  QL V  GI+LAY+ G    WR LA+LG  P  +++  + ++PE+
Sbjct: 146 SEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPET 205

Query: 206 PRWLAEMGLMERFESSLQTLRGSN---VDITMEAQEIQNRFYTVCRPQEEKILVSFDGIG 262
           PR+L      +   ++L+ L GS     +  + A+    +   + RP   K L+   GI 
Sbjct: 206 PRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLALLRRPGIYKPLII--GIS 263

Query: 263 LLVLQQLSGINGVFFYASKIFASAGISSSDAATFGLGAIQVVMTGVATWLVDKSGRRILL 322
           L+V QQLSG+N + FYA+ IF  A    S  A+  +G IQV+ T VA  ++D++GRR+LL
Sbjct: 264 LMVFQQLSGVNAIMFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLL 323

Query: 323 IVSSSIMTISLLLVASAFYLE----------GVVSKGSELHNI---LGILSVVGLVALII 369
            +S  IM  S+    + F L           G+V   +E  ++   L  L+V  +   I 
Sbjct: 324 ALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIA 383

Query: 370 GFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTANFLLNW-SSAGTFTI 428
           GFA+G GPIPWL+MSEI P ++KG+A  +   +NWF A ++T   + ++      G F +
Sbjct: 384 GFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWL 443

Query: 429 YAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            A F A +V F L  VPETK RTLE++ A F
Sbjct: 444 TAAFCALSVLFTLTVVPETKGRTLEQVTAHF 474


>GTR8_HUMAN (Q9NY64) Solute carrier family 2, facilitated glucose
           transporter, member 8 (Glucose transporter type 8)
           (Glucose transporter type X1)
          Length = 477

 Score =  263 bits (672), Expect = 7e-70
 Identities = 164/449 (36%), Positives = 236/449 (52%), Gaps = 19/449 (4%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDL----NLSISRFSLFGSLSNVGAMVGAT 85
           V L     ALGP+ FGF  GYSSP    + R       L  +  S FG++  +GA  G  
Sbjct: 26  VFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGV 85

Query: 86  VSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYI 145
           + G L +  GRK SLL+ +VP + G+  I+ A+D  +L  GRLL G   G+ S V PVYI
Sbjct: 86  LGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYI 145

Query: 146 AEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFNWRTLALLGVFPCAILIPGLYFIPES 205
           +EI    +RG LG+  QL V +GI+LAYL G    WR LA+LG  P ++++  + F+PE+
Sbjct: 146 SEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPET 205

Query: 206 PRWLAEMGLMERFESSLQTLRGSNVDITMEAQEIQNRFYTVCRPQEEKILVSFDGIGLLV 265
           PR+L      +   ++L+ L GS           +  F+     Q         G+ L+ 
Sbjct: 206 PRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMA 265

Query: 266 LQQLSGINGVFFYASKIFASAGISSSDAATFGLGAIQVVMTGVATWLVDKSGRRILLIVS 325
            QQLSG+N V FYA  IF  A    S  A+  +G IQV+ T VA  ++D++GRR+LL++S
Sbjct: 266 FQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLS 325

Query: 326 SSIMTISLLLVASAFYL--------------EGVVSKGSELHNILGILSVVGLVALIIGF 371
             +M  S     + F L                V ++  +    L  L+V  +   I GF
Sbjct: 326 GVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGF 385

Query: 372 ALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTANFLLN-WSSAGTFTIYA 430
           A+G GPIPWL+MSEI P ++KG+A  +   +NW  A ++T   + L+      G F + +
Sbjct: 386 AVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLAS 445

Query: 431 IFSAFTVAFALLFVPETKDRTLEEIQASF 459
            F  F+V F    VPETK +TLE+I A F
Sbjct: 446 AFCIFSVLFTFSCVPETKGKTLEQITAHF 474


>GTR6_HUMAN (Q9UGQ3) Solute carrier family 2, facilitated glucose
           transporter, member 6 (Glucose transporter type 6)
           (Glucose transporter type 9)
          Length = 507

 Score =  223 bits (568), Expect = 8e-58
 Identities = 163/472 (34%), Positives = 244/472 (51%), Gaps = 53/472 (11%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIR----DLNLSISRFSLFGSLSNVGAMVGAT 85
           V L      LG   FG+   Y+SP    + R    DL+L+ S+ S FGS+  +GA  G  
Sbjct: 38  VFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGL 97

Query: 86  VSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYI 145
            +  L +  GRK S++ +AVP+  G+  ++ A    +L +GR L GF  G+ +  +PVY+
Sbjct: 98  SAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYV 157

Query: 146 AEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFNWRTLALLGVFPCAILIPGLYFIPES 205
           +EI P  +RG+LGA  QL    G +  Y LGL   WR LA+ G  P  I+I  L F+P S
Sbjct: 158 SEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNS 217

Query: 206 PRWLAEMGLMERFESSLQTLRGSNVDITMEAQEIQN--------------RFYTVCRPQE 251
           PR+L   G  E    +L  LRG++VD+  E ++IQ+              R   VCRP  
Sbjct: 218 PRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPIT 277

Query: 252 EKILVSFDGIGLLVLQQLSGINGVFFYASKIFASAGI---SSSDAATFGLGAIQVVMTGV 308
             +L       + +LQQL+GI  +  Y   IF S  +      DAA   +GA++++   +
Sbjct: 278 VALL-------MRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAI--VGAVRLLSVLI 328

Query: 309 ATWLVDKSGRRILLIVSSSIM-----TISLLLVASAFYLEGVVSKGSE----------LH 353
           A   +D +GR++LL VS++IM     T+ L +      L    + G E          L 
Sbjct: 329 AALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLA 388

Query: 354 NILGILSVVGLVA---LIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVI 410
              G L++V L+A    I+G+A+G GPI WL+MSE+LP   +G+A  +   ++W TA V 
Sbjct: 389 APAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFV- 447

Query: 411 TLTANFLLNWSSAG---TFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            LT +FL   S+ G    F  +A     ++ F    VPETK R+LE+I++ F
Sbjct: 448 -LTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFF 498


>GTR3_RAT (Q07647) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 493

 Score =  204 bits (518), Expect = 5e-52
 Identities = 147/475 (30%), Positives = 232/475 (47%), Gaps = 64/475 (13%)

Query: 30  VVLCVLVVALGPIQFGFTCG-----------YSSPTQEEMIRDL---NLSISRFSLFGSL 75
           +V  V V  +G  QFG+  G           + + T EE + DL    L  + +SL  ++
Sbjct: 10  LVFAVTVATIGSFQFGYNTGVINAPETIIKDFLNYTLEERLEDLPREGLLTTLWSLCVAI 69

Query: 76  SNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSS---LLFIGRLLEGF 132
            +VG M+G+   G     FGR+ S+L+  +  I G   +  AK +    +L +GRL+ G 
Sbjct: 70  FSVGGMIGSFSVGLFVNRFGRRNSMLLVNLIAILGGCLMGFAKIAESVEMLILGRLIIGI 129

Query: 133 GVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WRTLAL 186
             G+ +  VP+YI E+ P  +RG+ G +NQL + +GI++A + GL F       W  L  
Sbjct: 130 FCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQVFGLDFILGSEELWPGLLG 189

Query: 187 LGVFPCAILIPGLYFIPESPRWLAEMGLMERFESS-----LQTLRGSNVDITMEAQEIQN 241
           L + P  +    L F PESPR+L    L+ R E       LQ L G+  D+  E QE+++
Sbjct: 190 LTIIPAILQSAALPFCPESPRFL----LINRKEEDQATEILQRLWGTP-DVIQEIQEMKD 244

Query: 242 RFYTVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSS 291
               + + ++  +L  F            + L + QQ SGIN VF+Y++ IF  AG+   
Sbjct: 245 ESIRMSQEKQVTVLELFKSPSYFQPLLISVVLQLSQQFSGINAVFYYSTGIFQDAGVQEP 304

Query: 292 DAATFGLGAIQVVMTGVATWLVDKSGRRIL-------LIVSSSIMTISLLLVASAFYLEG 344
             AT G G +  + T V+ +LV+++GRR L       + V S  MTISLLL         
Sbjct: 305 IYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSVFMTISLLL--------- 355

Query: 345 VVSKGSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNW 404
                 + +  +  + +V ++  +  F +G GPIPW I++E+     +  A +VA  SNW
Sbjct: 356 -----KDEYEAMSFVCIVAILVYVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNW 410

Query: 405 FTASVITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            +  ++ +       +  A  F I+A F  F + F    VPETK RT E+I  +F
Sbjct: 411 TSNFLVGMFFPSAAAYLGAYVFIIFAAFLVFFLIFTSFKVPETKGRTFEDITRAF 465


>GTR3_MOUSE (P32037) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 493

 Score =  202 bits (514), Expect = 1e-51
 Identities = 146/472 (30%), Positives = 233/472 (48%), Gaps = 58/472 (12%)

Query: 30  VVLCVLVVALGPIQFGFTCG-----------YSSPTQEEMIRDL---NLSISRFSLFGSL 75
           +V  V V  +G  QFG+  G           + + T EE + DL    L  + +SL  ++
Sbjct: 10  LVFAVTVATIGSFQFGYNTGVINAPETILKDFLNYTLEERLEDLPSEGLLTALWSLCVAI 69

Query: 76  SNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSS---LLFIGRLLEGF 132
            +VG M+G+   G     FGR+ S+L+  +  I     +  AK +    +L +GRLL G 
Sbjct: 70  FSVGGMIGSFSVGLFVNRFGRRNSMLLVNLLAIIAGCLMGFAKIAESVEMLILGRLLIGI 129

Query: 133 GVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WRTLAL 186
             G+ +  VP+YI E+ P  +RG+ G +NQL + +GI++A + GL F       W  L  
Sbjct: 130 FCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQIFGLDFILGSEELWPGLLG 189

Query: 187 LGVFPCAILIPGLYFIPESPRWLAEMGLMERFESS--LQTLRGSNVDITMEAQEIQNRFY 244
           L + P  +    L F PESPR+L  +   E  +++  LQ L G++ D+  E QE+++   
Sbjct: 190 LTIIPAILQSAALPFCPESPRFLL-INKKEEDQATEILQRLWGTS-DVVQEIQEMKDESV 247

Query: 245 TVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSSDAA 294
            + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AG+     A
Sbjct: 248 RMSQEKQVTVLELFRSPNYVQPLLISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYA 307

Query: 295 TFGLGAIQVVMTGVATWLVDKSGRRIL-------LIVSSSIMTISLLLVASAFYLEGVVS 347
           T G G +  + T V+ +LV+++GRR L       + V S  MTISLLL            
Sbjct: 308 TIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSVFMTISLLL------------ 355

Query: 348 KGSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTA 407
              + +  +  + +V ++  +  F +G GPIPW I++E+     +  A +VA   NW + 
Sbjct: 356 --KDDYEAMSFVCIVAILIYVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGCCNWTSN 413

Query: 408 SVITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            ++ +       +  A  F I+A F  F + F    VPETK RT E+I  +F
Sbjct: 414 FLVGMLFPSAAAYLGAYVFIIFAAFLIFFLIFTFFKVPETKGRTFEDIARAF 465


>ITR2_YEAST (P30606) Myo-inositol transporter 2
          Length = 612

 Score =  199 bits (505), Expect = 2e-50
 Identities = 140/493 (28%), Positives = 243/493 (48%), Gaps = 44/493 (8%)

Query: 5   EDYEDSRNIRKPFINNNNAG-------SGSFFVVLCVLVVALGPIQFGFTCGYSSPTQEE 57
           ED +D R + KP  + ++         S S F++    V ++    FG+  GY S     
Sbjct: 80  EDEDDGRIVIKPVNDEDDTSVIITFNQSISPFIITLTFVASISGFMFGYDTGYISSALIS 139

Query: 58  MIRDLN---LSISRFSLFGSLSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAI 114
           + RDL+   L+     L  + +++GA++ +  +G  A+ FGR+  L+ + +  + G +  
Sbjct: 140 INRDLDNKVLTYGEKELITAATSLGALITSVGAGTAADVFGRRPCLMFSNLMFLIGAILQ 199

Query: 115 SLAKDSSLLFIGRLLEGFGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYL 174
             A     +  GRL+ GFGVGI S + P++I+EI P+ +RG L  +N L +T G ++AY 
Sbjct: 200 ITAHKFWQMAAGRLIMGFGVGIGSLISPLFISEIAPKMIRGRLTVINSLWLTGGQLIAYG 259

Query: 175 LGLFFN-----WRTLALLGVFPCAILIPGLYFIPESPRWLAEMGLMERFESSLQTLRGSN 229
            G   N     WR L  L + P  +      F+P++PR+    G ++R +  L+    + 
Sbjct: 260 CGAGLNHVKNGWRILVGLSLIPTVLQFSFFCFLPDTPRYYVMKGDLKRAKMVLKRSYVNT 319

Query: 230 VD--ITMEAQEIQN------------RFYTVCR-----PQEEKILVSFDGIGLLVLQQLS 270
            D  I  + +E+ +            +F+ + +     P   + L+   G GL  +QQ +
Sbjct: 320 EDEIIDQKVEELSSLNQSIPGKNPITKFWNMVKELHTVPSNFRALII--GCGLQAIQQFT 377

Query: 271 GINGVFFYASKIFASAGISSSDAATFGLGAIQVVMTGVATWLVDKSGRRILLIVSSSIMT 330
           G N + +++  IF + G  +S A +  +     V T +A + +DK GRR +L++    MT
Sbjct: 378 GWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKIGRRYILLIGLPGMT 437

Query: 331 ISLLLVASAFYLEGVVSKG------SELHNILGILSVVGLVALIIGFALGIGPIPWLIMS 384
           ++L++ A AF+  G+   G      S+  +  GI+ +V ++     +ALGIG +PW   S
Sbjct: 438 VALVICAIAFHFLGIKFNGADAVVASDGFSSWGIVIIVFIIVYAAFYALGIGTVPWQ-QS 496

Query: 385 EILPPNIKGLAGSVATFSNWFTASVITLT-ANFLLNWSSAGTFTIYAIFSAFTVAFALLF 443
           E+ P N++G+  S AT +NW  + VI  T    L N +  GTF+ +A  +  +  F    
Sbjct: 497 ELFPQNVRGVGTSYATATNWAGSLVIASTFLTMLQNITPTGTFSFFAGVACLSTIFCYFC 556

Query: 444 VPETKDRTLEEIQ 456
            PE     LEE+Q
Sbjct: 557 YPELSGLELEEVQ 569


>GTR2_HUMAN (P11168) Solute carrier family 2, facilitated glucose
           transporter, member 2 (Glucose transporter type 2,
           liver)
          Length = 524

 Score =  198 bits (503), Expect = 3e-50
 Identities = 137/429 (31%), Positives = 222/429 (50%), Gaps = 36/429 (8%)

Query: 55  QEEMIRDLNLSISRFSLFGSLSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAI 114
           +EE +    L    +SL  S   VG M  +   G L +  GR  ++LVA + ++ G + +
Sbjct: 83  EEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLM 142

Query: 115 SLAK---DSSLLFIGRLLEGFGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIML 171
             +K      L+  GR + G   G+IS +VP+YI EI P  +RG+LG  +QL++  GI++
Sbjct: 143 GFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILI 202

Query: 172 AYLLGLFFN------WRTLALLGVFPCAILIPGLYFIPESPRWL-AEMGLMERFESSLQT 224
           + ++GL F       W  L  L      +    L+F PESPR+L  ++    + + SL+ 
Sbjct: 203 SQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKR 262

Query: 225 LRGSNVDITMEAQEIQNRFYTVCRPQEEKILVSFDG----------IGLLVLQQLSGING 274
           LRG + D+T +  E++         Q+  I+  F            + L V QQ SGING
Sbjct: 263 LRGYD-DVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGING 321

Query: 275 VFFYASKIFASAGISSSDAATFGLGAIQVVMTGVATWLVDKSGRRILLIVSSSIMTISLL 334
           +F+Y++ IF +AGIS    AT G+GA+ +V T V+ +LV+K+GRR L ++  S M +  +
Sbjct: 322 IFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAI 381

Query: 335 LVASAFYLEGVVSKGSELHNILGILSVVGLVALII---GFALGIGPIPWLIMSEILPPNI 391
                      +S G  L N    +S V ++A+ +    F +G GPIPW +++E      
Sbjct: 382 F----------MSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGP 431

Query: 392 KGLAGSVATFSNWFTASVITLTANFLLNWSSAGTFTIYA-IFSAFTVAFALLFVPETKDR 450
           +  A ++A FSNW    ++ L   ++ ++     F ++A +  AFT+ F    VPETK +
Sbjct: 432 RPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTL-FTFFKVPETKGK 490

Query: 451 TLEEIQASF 459
           + EEI A F
Sbjct: 491 SFEEIAAEF 499


>GTR3_HUMAN (P11169) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 496

 Score =  197 bits (502), Expect = 4e-50
 Identities = 137/471 (29%), Positives = 232/471 (49%), Gaps = 56/471 (11%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLSI--------------SRFSLFGSL 75
           ++  + V  +G  QFG+  G  +  ++ +   +N ++              S +SL  ++
Sbjct: 10  LIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAI 69

Query: 76  SNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISL---AKDSSLLFIGRLLEGF 132
            +VG M+G+   G     FGR+ S+L+  +  + G   + L   AK   +L +GRL+ G 
Sbjct: 70  FSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGL 129

Query: 133 GVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFF------NWRTLAL 186
             G+ +  VP+YI EI P  +RG+ G +NQL + +GI++A + GL F       W  L  
Sbjct: 130 FCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLG 189

Query: 187 LGVFPCAILIPGLYFIPESPRW-LAEMGLMERFESSLQTLRGSNVDITMEAQEIQNRFYT 245
             + P  +    L F PESPR+ L      E  +  LQ L G+  D++ + QE+++    
Sbjct: 190 FTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESAR 248

Query: 246 VCRPQEEKILVSFD----------GIGLLVLQQLSGINGVFFYASKIFASAGISSSDAAT 295
           + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AG+     AT
Sbjct: 249 MSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYAT 308

Query: 296 FGLGAIQVVMTGVATWLVDKSGRRILLIVS-------SSIMTISLLLVASAFYLEGVVSK 348
            G G +  + T V+ +LV+++GRR L ++        S++MT+SLLL             
Sbjct: 309 IGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLL------------- 355

Query: 349 GSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTAS 408
             + +N +  + +  ++  +  F +G GPIPW I++E+     +  A +VA  SNW +  
Sbjct: 356 -KDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNF 414

Query: 409 VITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
           ++ L      ++  A  F I+  F    +AF    VPET+ RT E+I  +F
Sbjct: 415 LVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAF 465


>CSBC_BACSU (P46333) Probable metabolite transport protein csbC
          Length = 461

 Score =  197 bits (500), Expect = 6e-50
 Identities = 132/434 (30%), Positives = 223/434 (50%), Gaps = 21/434 (4%)

Query: 38  ALGPIQFGFTCGYSSPTQEEMIRDLNLSISRFSLFGSLSNVGAMVGATVSGHLAEYFGRK 97
           ALG + +G+  G  S     +  D+ L+     L  S+  +GA+ G+ +SG  ++ +GR+
Sbjct: 15  ALGGLLYGYDTGVISGALLFINNDIPLTTLTEGLVVSMLLLGAIFGSALSGTCSDRWGRR 74

Query: 98  GSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYIAEIPPRTMRGSL 157
             + V ++  I G +A + ++   +L   R++ G  VG  + +VPVY++E+ P  +RG+L
Sbjct: 75  KVVFVLSIIFIIGALACAFSQTIGMLIASRVILGLAVGGSTALVPVYLSEMAPTKIRGTL 134

Query: 158 GAVNQLSVTIGIMLAYLLGLFFN----WRTLALLGVFPCAILIPGLYFIPESPRWLAEMG 213
           G +N L +  GI+LAY++   F     WR +  L   P  +L+ G+ F+PESPRWL + G
Sbjct: 135 GTMNNLMIVTGILLAYIVNYLFTPFEAWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRG 194

Query: 214 LMERFESSLQTLRGSNVDITMEAQEIQ----NRFYTVCRPQEEKIL--VSFDGIGLLVLQ 267
             E     +  +     DI ME  E++     +  T     + K +  +   G+GL + Q
Sbjct: 195 -SEEEARRIMNITHDPKDIEMELAEMKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQ 253

Query: 268 QLSGINGVFFYASKIFASAGISSSDAA--TFGLGAIQVVMTGVATWLVDKSGRRILLIVS 325
           Q  GIN V +YA  IF  AG+ +S +A  T G+G + V+M   A  L+D+ GR+ LLI  
Sbjct: 254 QAVGINTVIYYAPTIFTKAGLGTSASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWG 313

Query: 326 SSIMTISLLLVASAFYLEGVVSKGSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSE 385
           S  +T+SL  ++      G+ +           ++VV L   I+ +    GP+ W++M E
Sbjct: 314 SVGITLSLAALSGVLLTLGLSAS-------TAWMTVVFLGVYIVFYQATWGPVVWVLMPE 366

Query: 386 ILPPNIKGLAGSVATFSNWFTASVITLTANFLLN-WSSAGTFTIYAIFSAFTVAFALLFV 444
           + P   +G A    T        +++L    +L+    A  F ++++    +  FA   V
Sbjct: 367 LFPSKARGAATGFTTLVLSAANLIVSLVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMV 426

Query: 445 PETKDRTLEEIQAS 458
           PETK ++LEEI+AS
Sbjct: 427 PETKGKSLEEIEAS 440


>XYLT_LACBR (O52733) D-xylose-proton symporter (D-xylose
           transporter)
          Length = 457

 Score =  196 bits (497), Expect = 1e-49
 Identities = 134/441 (30%), Positives = 227/441 (51%), Gaps = 33/441 (7%)

Query: 38  ALGPIQFGFTCGYSSPTQEEMIRDLNLSISRFSLFGSLSNVGAMVGATVSGHLAEYFGRK 97
           ALG + FG+  G  S     + + +NL   +     S   +GA++GA + G  ++ FGR+
Sbjct: 14  ALGGLLFGYDTGVISGAILFIQKQMNLGSWQQGWVVSAVLLGAILGAAIIGPSSDRFGRR 73

Query: 98  GSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYIAEIPPRTMRGSL 157
             LL++A+    G +  + + +   L I R++ G  VG  S ++P Y+AE+ P   RG++
Sbjct: 74  KLLLLSAIIFFVGALGSAFSPEFWTLIISRIILGMAVGAASALIPTYLAELAPSDKRGTV 133

Query: 158 GAVNQLSVTIGIMLAYLL-----GLFFNWRTLALLGVFPCAILIPGLYFIPESPRWLAEM 212
            ++ QL V  GI+LAY+      G +  WR +      P A+L  G   +PESPR+L + 
Sbjct: 134 SSLFQLMVMTGILLAYITNYSFSGFYTGWRWMLGFAAIPAALLFLGGLILPESPRFLVKS 193

Query: 213 GLMERFESSLQTL-RGSNVDITMEAQEIQNR-----------FYTVCRPQEEKILVSFDG 260
           G ++     L T+ +   V +  E  +IQ             F  + RP    +++   G
Sbjct: 194 GHLDEARHVLDTMNKHDQVAVNKEINDIQESAKIVSGGWSELFGKMVRP---SLII---G 247

Query: 261 IGLLVLQQLSGINGVFFYASKIFASA--GISSSDAATFGLGAIQVVMTGVATWLVDKSGR 318
           IGL + QQ+ G N V +YA  IF     G+S++  A  G+G   V++T +A  ++DK  R
Sbjct: 248 IGLAIFQQVMGCNTVLYYAPTIFTDVGFGVSAALLAHIGIGIFNVIVTAIAVAIMDKIDR 307

Query: 319 RILLIVSSSIMTISLLLVASAFYLEGVVSKGSELHNILGILSVVGLVALIIGFALGIGPI 378
           + ++ + +  M ISL +++      G    GS+      I+SV+ L   I  F+   GP+
Sbjct: 308 KKIVNIGAVGMGISLFVMSIGMKFSG----GSQ---TAAIISVIALTVYIAFFSATWGPV 360

Query: 379 PWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTANFLLNWSSAGTFTI-YAIFSAFTV 437
            W+++ E+ P NI+GL  S A+  NW    +++LT   LL++   G+  I Y I    ++
Sbjct: 361 MWVMIGEVFPLNIRGLGNSFASVINWTANMIVSLTFPSLLDFFGTGSLFIGYGILCFASI 420

Query: 438 AFALLFVPETKDRTLEEIQAS 458
            F    V ET++R+LE+I+A+
Sbjct: 421 WFVQKKVFETRNRSLEDIEAT 441


>GALP_ECOLI (P37021) Galactose-proton symporter (Galactose
           transporter)
          Length = 464

 Score =  195 bits (495), Expect = 2e-49
 Identities = 133/449 (29%), Positives = 228/449 (50%), Gaps = 24/449 (5%)

Query: 27  SFFVVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLSISRFSLFGSLSNVGAMVGATV 86
           +FFV  C L  AL  + FG   G  +     +  +  ++        S    GA VGA  
Sbjct: 15  TFFV--CFLA-ALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVG 71

Query: 87  SGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYIA 146
           SG L+   GRK SL++ A+  + G +  + A +  +L + R+L G  VG+ SY  P+Y++
Sbjct: 72  SGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLS 131

Query: 147 EIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN----WRTLALLGVFPCAILIPGLYFI 202
           EI P  +RGS+ ++ QL +TIGI+ AYL    F+    WR +  + + P  +L+ G++F+
Sbjct: 132 EIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPAILLLIGVFFL 191

Query: 203 PESPRWLAEMGLMERFESSLQTLRGSNVDITMEAQEIQNRF------YTVCRPQEEKILV 256
           P+SPRW A        E  L  LR ++ +   E  EI+         + + +        
Sbjct: 192 PDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFKENSNFRRA 251

Query: 257 SFDGIGLLVLQQLSGINGVFFYASKIFASAGISSSDAATFG---LGAIQVVMTGVATWLV 313
            F G+ L V+QQ +G+N + +YA KIF  AG +++    +G   +G   V+ T +A  LV
Sbjct: 252 VFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLV 311

Query: 314 DKSGRRILLIVSSSIMTISLLLVASAFYLEGVVSKGSELHNILGILSVVGLVALIIGFAL 373
           D+ GR+  L +   +M   + ++ +  ++ G+ S  ++        ++  L+  I+GFA+
Sbjct: 312 DRWGRKPTLTLGFLVMAAGMGVLGTMMHI-GIHSPSAQ------YFAIAMLLMFIVGFAM 364

Query: 374 GIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTANFLLN-WSSAGTFTIYAIF 432
             GP+ W++ SEI P   +    + +T +NW    ++  T   +LN   +A TF +YA  
Sbjct: 365 SAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAAL 424

Query: 433 SAFTVAFALLFVPETKDRTLEEIQASFIR 461
           +   +   L  VPETK  +LE I+ + ++
Sbjct: 425 NVLFILLTLWLVPETKHVSLEHIERNLMK 453


>GTR3_SHEEP (P47843) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 494

 Score =  194 bits (494), Expect = 3e-49
 Identities = 139/472 (29%), Positives = 230/472 (48%), Gaps = 58/472 (12%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRD-LNLSI--------------SRFSLFGS 74
           ++  + +  +G  QFG+  G  +   E +I+D LN ++              S +SL  +
Sbjct: 10  LIFAISIATIGSFQFGYNTGVIN-APEAIIKDFLNYTLEERSETPPSSVLLTSLWSLSVA 68

Query: 75  LSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAIS---LAKDSSLLFIGRLLEG 131
           + +VG M+G+   G     FGR+ S+L+  +  I G   +    +A+   +L +GRL+ G
Sbjct: 69  IFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAIAGGCLMGFCKIAESVEMLILGRLIIG 128

Query: 132 FGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WRTLA 185
              G+ +  VP+YI EI P  +RG+ G +NQL + IGI++A + GL         W  L 
Sbjct: 129 LFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLKVILGTEDLWPLLL 188

Query: 186 LLGVFPCAILIPGLYFIPESPRWLA-EMGLMERFESSLQTLRGSNVDITMEAQEIQNRFY 244
              + P  I    L F PESPR+L       E+ +  LQ L G+  D+  + QE+++   
Sbjct: 189 GFTILPAIIQCAALPFCPESPRFLLINRKEEEKAKEILQRLWGTE-DVAQDIQEMKDESM 247

Query: 245 TVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSSDAA 294
            + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AG+     A
Sbjct: 248 RMSQEKQVTVLELFRAPNYRQPIIISIMLQLSQQLSGINAVFYYSTGIFKDAGVQEPVYA 307

Query: 295 TFGLGAIQVVMTGVATWLVDKSGRRILLIVS-------SSIMTISLLLVASAFYLEGVVS 347
           T G G +  + T V+ +LV+++GRR L ++        S +MTISLLL            
Sbjct: 308 TIGAGVVNTIFTVVSVFLVERAGRRTLHLIGLGGMAFCSILMTISLLL------------ 355

Query: 348 KGSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTA 407
              + ++ +  + +  ++  +  F +G GPIPW I++E+     +  A +VA  SNW + 
Sbjct: 356 --KDNYSWMSFICIGAILVFVAFFEIGPGPIPWFIVAELFGQGPRPAAMAVAGCSNWTSN 413

Query: 408 SVITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            ++ L       +  A  F ++ +F      F    VPET+ RT EEI  +F
Sbjct: 414 FLVGLLFPSATFYLGAYVFIVFTVFLVIFWVFTFFKVPETRGRTFEEITRAF 465


>ARAE_BACSU (P96710) Arabinose-proton symporter (Arabinose
           transporter)
          Length = 464

 Score =  194 bits (494), Expect = 3e-49
 Identities = 135/461 (29%), Positives = 227/461 (48%), Gaps = 46/461 (9%)

Query: 29  FVVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLSISRF--SLFGSLSNVGAMVGATV 86
           FV+L      LG + +G+     S      ++DL  S+S F   L  S   +G +VG  +
Sbjct: 22  FVILISCAAGLGGLLYGYDTAVISGAIG-FLKDL-YSLSPFMEGLVISSIMIGGVVGVGI 79

Query: 87  SGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSSLLFIGRLLEGFGVGIISYVVPVYIA 146
           SG L++ FGR+  L+ AA+      +  +L++D S L I R++ G G+G+ S +   YI 
Sbjct: 80  SGFLSDRFGRRKILMTAALLFAISAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYIT 139

Query: 147 EIPPRTMRGSLGAVNQLSVTIGIMLAYLL------------GLFFNWRTLALLGVFPCAI 194
           E  P  +RGSL ++ QL   +GI   Y +            G+   WR +   G+ P  I
Sbjct: 140 EAAPPAIRGSLSSLYQLFTILGISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVI 199

Query: 195 LIPGLYFIPESPRWLAEMGLMERFESSLQTLRGSNVDITMEAQEIQN--------RFYTV 246
               L  +PESPRWLA+ G        L  + G  V    E + I+N            +
Sbjct: 200 FFLVLLVVPESPRWLAKAGKTNEALKILTRINGETV-AKEELKNIENSLKIEQMGSLSQL 258

Query: 247 CRPQEEKILVSFDGIGLLVLQQLSGINGVFFYASKIFASAGI--SSSDAATFGLGAIQVV 304
            +P   K LV   GI L +  Q+ G+N + +Y  +IF   G   ++    T  +G ++V+
Sbjct: 259 FKPGLRKALVI--GILLALFNQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVI 316

Query: 305 MTGVATWLVDKSGRRILLIVSSSIMTISLLLVASAFYLEGVVSKGSELHNILGILSVVGL 364
            T +A  L+DK GR+ L+ + S+ M I ++L+ ++FY E             GI+ +V +
Sbjct: 317 FTVIAVLLIDKVGRKKLMSIGSAFMAIFMILIGTSFYFE----------LTSGIMMIVLI 366

Query: 365 VALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATF----SNWFTASVITLTANFLLNW 420
           +  +  F + +GPI W+++SEI P +++  A  +AT     +NW     + +  +   ++
Sbjct: 367 LGFVAAFCVSVGPITWIMISEIFPNHLRARAAGIATIFLWGANWAIGQFVPMMID---SF 423

Query: 421 SSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASFIR 461
             A TF I+A+ +     F +   PETK+++LEEI+  +I+
Sbjct: 424 GLAYTFWIFAVINILCFLFVVTICPETKNKSLEEIEKLWIK 464


>GTR4_MOUSE (P14142) Solute carrier family 2, facilitated glucose
           transporter, member 4 (Glucose transporter type 4,
           insulin-responsive) (GT2)
          Length = 509

 Score =  194 bits (493), Expect = 4e-49
 Identities = 139/471 (29%), Positives = 235/471 (49%), Gaps = 48/471 (10%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLS------------------ISRFSL 71
           +VL V    LG +QFG+  G  +  Q+ + +  N +                   + ++L
Sbjct: 24  LVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWAL 83

Query: 72  FGSLSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAK---DSSLLFIGRL 128
             ++ +VG M+ + + G ++++ GRK ++L   V  + G   + LA       +L +GR 
Sbjct: 84  SVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAVASYEILILGRF 143

Query: 129 LEGFGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WR 182
           L G   G+ S +VP+Y+ EI P  +RG+LG +NQL++ IGI++A +LGL         W 
Sbjct: 144 LIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWP 203

Query: 183 TLALLGVFPCAILIPGLYFIPESPRWLAEMGLMER-FESSLQTLRGSNVDITMEAQEIQN 241
            L  L V P  + +  L F PESPR+L  +  +E     SL+ L G   D++    E+++
Sbjct: 204 LLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGW-ADVSDALAELKD 262

Query: 242 RFYTVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSS 291
               + R +   +L               + L + QQLSGIN VF+Y++ IF SAG+   
Sbjct: 263 EKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQP 322

Query: 292 DAATFGLGAIQVVMTGVATWLVDKSGRRIL-LIVSSSIMTISLLLVASAFYLEGVVSKGS 350
             AT G G +  V T V+  LV+++GRR L L+  + +   ++L+  +   LE V +   
Sbjct: 323 AYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPA--- 379

Query: 351 ELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVI 410
                +  +S+V +   +  F +G GPIPW I++E+     +  A +VA FSNW    ++
Sbjct: 380 -----MSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIV 434

Query: 411 TLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASFIR 461
            +   ++ +      F ++A+       F  L VPET+ RT ++I A+F R
Sbjct: 435 GMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAFRR 485


>GTR3_CHICK (P28568) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3)
           (CEF-GT3)
          Length = 496

 Score =  194 bits (493), Expect = 4e-49
 Identities = 141/464 (30%), Positives = 232/464 (49%), Gaps = 44/464 (9%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLSISR--------------FSLFGSL 75
           ++  V V A+G +QFG+  G  +  ++ +    N ++S+              +SL  ++
Sbjct: 11  LIYAVSVAAIGSLQFGYNTGVINAPEKIIQAFYNRTLSQRSGETISPELLTSLWSLSVAI 70

Query: 76  SNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISL---AKDSSLLFIGRLLEGF 132
            +VG M+G+         FGR+ S+L+  V    G   ++L   AK   +L IGR + G 
Sbjct: 71  FSVGGMIGSFSVSLFFNRFGRRNSMLLVNVLAFAGGALMALSKIAKAVEMLIIGRFIIGL 130

Query: 133 GVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFNWRTLAL----LG 188
             G+ +  VP+YI+E+ P ++RG+ G +NQL + +GI++A + GL     T AL    LG
Sbjct: 131 FCGLCTGFVPMYISEVSPTSLRGAFGTLNQLGIVVGILVAQIFGLEGIMGTEALWPLLLG 190

Query: 189 --VFPCAILIPGLYFIPESPRWLAEMGLME-RFESSLQTLRGSNVDITMEAQEIQNRFYT 245
             + P  +    L F PESPR+L    + E + ++ LQ LRG+  D++ +  E++     
Sbjct: 191 FTIVPAVLQCVALLFCPESPRFLLINKMEEEKAQTVLQKLRGTQ-DVSQDISEMKEESAK 249

Query: 246 VCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSSDAAT 295
           + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AGI+    AT
Sbjct: 250 MSQEKKATVLELFRSPNYRQPIIISITLQLSQQLSGINAVFYYSTGIFERAGITQPVYAT 309

Query: 296 FGLGAIQVVMTGVATWLVDKSGRRILLIVSSSIMTISLLLVASAFYLEGVVSKGSELHNI 355
            G G +  V T V+ +LV+++GRR L +V    M +   ++  A  L+       +    
Sbjct: 310 IGAGVVNTVFTVVSLFLVERAGRRTLHLVGLGGMAVCAAVMTIALALK------EKWIRY 363

Query: 356 LGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVITLTAN 415
           + I++  G VAL   F +G GPIPW I++E+     +  A +VA  SNW +  ++ +   
Sbjct: 364 ISIVATFGFVAL---FEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGMLFP 420

Query: 416 FLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
           +         F I+ +F      F    VPETK RT E+I   F
Sbjct: 421 YAEKLCGPYVFLIFLVFLLIFFIFTYFKVPETKGRTFEDISRGF 464


>GTR4_HUMAN (P14672) Solute carrier family 2, facilitated glucose
           transporter, member 4 (Glucose transporter type 4,
           insulin-responsive)
          Length = 509

 Score =  193 bits (491), Expect = 7e-49
 Identities = 140/471 (29%), Positives = 238/471 (49%), Gaps = 48/471 (10%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLS------------------ISRFSL 71
           +VL V    LG +QFG+  G  +  Q+ + +  N +                   + ++L
Sbjct: 24  LVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWAL 83

Query: 72  FGSLSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSS---LLFIGRL 128
             ++ +VG M+ + + G ++++ GRK ++LV  V  + G   + LA  ++   +L +GR 
Sbjct: 84  SVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRF 143

Query: 129 LEGFGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGL------FFNWR 182
           L G   G+ S +VP+Y+ EI P  +RG+LG +NQL++ IGI++A +LGL         W 
Sbjct: 144 LIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWP 203

Query: 183 TLALLGVFPCAILIPGLYFIPESPRWLAEMGLMER-FESSLQTLRGSNVDITMEAQEIQN 241
            L  L V P  + +  L F PESPR+L  +  +E     SL+ L G   D++    E+++
Sbjct: 204 LLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGW-ADVSGVLAELKD 262

Query: 242 RFYTVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSS 291
               + R +   +L               + L + QQLSGIN VF+Y++ IF +AG+   
Sbjct: 263 EKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQP 322

Query: 292 DAATFGLGAIQVVMTGVATWLVDKSGRRIL-LIVSSSIMTISLLLVASAFYLEGVVSKGS 350
             AT G G +  V T V+  LV+++GRR L L+  + +   ++L+  +   LE V +   
Sbjct: 323 AYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPA--- 379

Query: 351 ELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVI 410
                +  +S+V +   +  F +G GPIPW I++E+     +  A +VA FSNW +  +I
Sbjct: 380 -----MSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFII 434

Query: 411 TLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASFIR 461
            +   ++        F ++A+       F  L VPET+ RT ++I A+F R
Sbjct: 435 GMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHR 485


>GTR3_BOVIN (P58352) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 494

 Score =  193 bits (491), Expect = 7e-49
 Identities = 140/472 (29%), Positives = 229/472 (47%), Gaps = 58/472 (12%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRD-LNLSI--------------SRFSLFGS 74
           ++  + V  +G  QFG+  G  +   E +I+D LN ++              S +SL  +
Sbjct: 10  LIFAISVATIGSFQFGYNTGVIN-APEAIIKDFLNYTLEERSEPPPSSVLLTSLWSLSVA 68

Query: 75  LSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAIS---LAKDSSLLFIGRLLEG 131
           + +VG M+G+   G     FGR  S+L+  +  I G   +    +A+   +L +GRL+ G
Sbjct: 69  IFSVGGMIGSFSVGLFVNRFGRGNSMLIVNLLAIAGGCLMGFCKIAESVEMLILGRLIIG 128

Query: 132 FGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WRTLA 185
              G+ +  VP+YI EI P  +RG+ G +NQL + IGI++A + GL         W  L 
Sbjct: 129 LFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLKVILGTEDLWPLLL 188

Query: 186 LLGVFPCAILIPGLYFIPESPRWLA-EMGLMERFESSLQTLRGSNVDITMEAQEIQNRFY 244
              + P  I    L F PESPR+L       E+ +  LQ L G+  D+  + QE+++   
Sbjct: 189 GFTILPAIIQCAALPFCPESPRFLLINRKEEEKAKEILQRLWGTE-DVAQDIQEMKDESM 247

Query: 245 TVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSSDAA 294
            + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AG+     A
Sbjct: 248 RMSQEKQVTVLELFRAPNYRQPIIISIMLQLSQQLSGINAVFYYSTGIFKDAGVQEPVYA 307

Query: 295 TFGLGAIQVVMTGVATWLVDKSGRRILLIVS-------SSIMTISLLLVASAFYLEGVVS 347
           T G G +  + T V+ +LV+++GRR L ++        S +MTISLLL            
Sbjct: 308 TIGAGVVNTIFTVVSVFLVERAGRRTLHLIGLGGMAFCSILMTISLLL------------ 355

Query: 348 KGSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTA 407
              + ++ +  + +  ++  +  F +G GPIPW I++E+     +  A +VA  SNW + 
Sbjct: 356 --KDNYSWMSFICIGAILVFVAFFEIGPGPIPWFIVAELFGQGPRPAAMAVAGCSNWTSN 413

Query: 408 SVITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
            ++ L       +  A  F ++ +F      F    VPET+ RT EEI  +F
Sbjct: 414 FLVGLLFPSAAFYLGAYVFIVFTVFLVIFWVFTFFKVPETRGRTFEEITRAF 465


>GTR4_RAT (P19357) Solute carrier family 2, facilitated glucose
           transporter, member 4 (Glucose transporter type 4,
           insulin-responsive)
          Length = 509

 Score =  192 bits (489), Expect = 1e-48
 Identities = 138/471 (29%), Positives = 236/471 (49%), Gaps = 48/471 (10%)

Query: 30  VVLCVLVVALGPIQFGFTCGYSSPTQEEMIRDLNLS------------------ISRFSL 71
           +VL V    LG +QFG+  G  +  Q+ + +  N +                   + ++L
Sbjct: 24  LVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWAL 83

Query: 72  FGSLSNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAISLAKDSS---LLFIGRL 128
             ++ +VG M+ + + G ++++ GRK ++L   V  + G   + LA  ++   +L +GR 
Sbjct: 84  SVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRF 143

Query: 129 LEGFGVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WR 182
           L G   G+ S +VP+Y+ EI P  +RG+LG +NQL++ IGI++A +LGL         W 
Sbjct: 144 LIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWP 203

Query: 183 TLALLGVFPCAILIPGLYFIPESPRWLAEMGLMER-FESSLQTLRGSNVDITMEAQEIQN 241
            L  + V P  + +  L F PESPR+L  +  +E     SL+ L G   D++    E+++
Sbjct: 204 LLLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGW-ADVSDALAELKD 262

Query: 242 RFYTVCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSS 291
               + R +   +L               + L + QQLSGIN VF+Y++ IF  AG+   
Sbjct: 263 EKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQP 322

Query: 292 DAATFGLGAIQVVMTGVATWLVDKSGRRIL-LIVSSSIMTISLLLVASAFYLEGVVSKGS 350
             AT G G +  V T V+  LV+++GRR L L+  + +   ++L+  +   LE V S   
Sbjct: 323 AYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPS--- 379

Query: 351 ELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTASVI 410
                +  +S+V +   +  F +G GPIPW I++E+     +  A +VA FSNW    ++
Sbjct: 380 -----MSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIV 434

Query: 411 TLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASFIR 461
            +   ++ +      F ++A+       F  L VPET+ RT ++I A+F R
Sbjct: 435 GMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISATFRR 485


>GTR3_CANFA (P47842) Solute carrier family 2, facilitated glucose
           transporter, member 3 (Glucose transporter type 3,
           brain)
          Length = 495

 Score =  192 bits (489), Expect = 1e-48
 Identities = 139/471 (29%), Positives = 228/471 (47%), Gaps = 56/471 (11%)

Query: 30  VVLCVLVVALGPIQFGFTCG-----------YSSPTQEEMIRDLNLSI---SRFSLFGSL 75
           ++  + +  +G  QFG+  G           + + T EE   +L   +   S +SL  ++
Sbjct: 10  LIFALSIATIGSFQFGYNTGVINAPETIIKDFLNYTLEEKSENLPTEVLLTSLWSLSVAI 69

Query: 76  SNVGAMVGATVSGHLAEYFGRKGSLLVAAVPNIFGWVAIS---LAKDSSLLFIGRLLEGF 132
            +VG M+G+   G     FGR+ S+L+  +  + G   +    +A+   +L +GRL+ G 
Sbjct: 70  FSVGGMIGSFSVGLFVNRFGRRNSMLMVNLLAVAGGCLMGFCKIAQSVEMLILGRLIIGL 129

Query: 133 GVGIISYVVPVYIAEIPPRTMRGSLGAVNQLSVTIGIMLAYLLGLFFN------WRTLAL 186
             G+ +  VP+YI EI P  +RG+ G +NQL + IGI++A + GL         W  L  
Sbjct: 130 FCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLKVIMGTEELWPLLLG 189

Query: 187 LGVFPCAILIPGLYFIPESPRWLA-EMGLMERFESSLQTLRGSNVDITMEAQEIQNRFYT 245
             + P  +    L F PESPR+L       E  +  LQ L G+  D++ + QE+++    
Sbjct: 190 FTIIPAVLQSAALPFCPESPRFLLINRKEEENAKEILQRLWGTQ-DVSQDIQEMKDESAR 248

Query: 246 VCRPQEEKILVSFDG----------IGLLVLQQLSGINGVFFYASKIFASAGISSSDAAT 295
           + + ++  +L  F            I L + QQLSGIN VF+Y++ IF  AG+     AT
Sbjct: 249 MAQEKQVTVLELFRSRSYRQPIIISIMLQLSQQLSGINAVFYYSTGIFKDAGVEEPIYAT 308

Query: 296 FGLGAIQVVMTGVATWLVDKSGRRIL-------LIVSSSIMTISLLLVASAFYLEGVVSK 348
            G G +  + T V+ +LV+++GRR L       + V S +MTISLLL             
Sbjct: 309 IGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSILMTISLLL------------- 355

Query: 349 GSELHNILGILSVVGLVALIIGFALGIGPIPWLIMSEILPPNIKGLAGSVATFSNWFTAS 408
             + +N +  + +  ++  +  F +G GPIPW I++E+     +  A +VA  SNW +  
Sbjct: 356 -KDNYNWMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNF 414

Query: 409 VITLTANFLLNWSSAGTFTIYAIFSAFTVAFALLFVPETKDRTLEEIQASF 459
           ++ L       +  A  F I+  F    + F    VPET+ RT EEI  +F
Sbjct: 415 LVGLLFPSAAFYLGAYVFIIFTGFLIVFLVFTFFKVPETRGRTFEEITRAF 465


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.325    0.141    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,622,589
Number of Sequences: 164201
Number of extensions: 2003298
Number of successful extensions: 7871
Number of sequences better than 10.0: 278
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 7057
Number of HSP's gapped (non-prelim): 402
length of query: 461
length of database: 59,974,054
effective HSP length: 114
effective length of query: 347
effective length of database: 41,255,140
effective search space: 14315533580
effective search space used: 14315533580
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)