BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0278.2
         (507 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ARP_ARATH (P45951) Apurinic endonuclease-redox protein (DNA-(apu...   584  e-166
EXOA_BACSU (P37454) Exodeoxyribonuclease (EC 3.1.11.2)                263  6e-70
APEA_DICDI (P51173) DNA-(apurinic or apyrimidinic site) lyase (E...   245  2e-64
APE1_BOVIN (P23196) DNA-(apurinic or apyrimidinic site) lyase (E...   242  1e-63
APE1_HUMAN (P27695) DNA-(apurinic or apyrimidinic site) lyase (E...   242  2e-63
APE1_RAT (P43138) DNA-(apurinic or apyrimidinic site) lyase (EC ...   241  3e-63
APE1_MOUSE (P28352) DNA-(apurinic or apyrimidinic site) lyase (E...   240  5e-63
RRP1_DROME (P27864) Recombination repair protein 1 (DNA-(apurini...   224  4e-58
EXOA_STRPN (P21998) Exodeoxyribonuclease (EC 3.1.11.2)                197  7e-50
EX3_SALTY (Q9Z612) Exodeoxyribonuclease III (EC 3.1.11.2) (Exonu...   100  2e-20
EX3_ECOLI (P09030) Exodeoxyribonuclease III (EC 3.1.11.2) (Exonu...    99  3e-20
APN2_SCHPO (P87175) DNA-(apurinic or apyrimidinic site) lyase 2 ...    92  2e-18
EX3_HAEIN (P44318) Exodeoxyribonuclease III (EC 3.1.11.2) (Exonu...    92  4e-18
APN2_YEAST (P38207) DNA-(apurinic or apyrimidinic site) lyase 2 ...    66  2e-10
LIN1_HUMAN (P08547) LINE-1 reverse transcriptase homolog               46  2e-04
DH47_ARATH (P31168) Dehydrin COR47 (Cold-induced COR47 protein)        43  0.002
YKQ0_CAEEL (P34305) Putative ATP-dependent RNA helicase C06E1.10...    43  0.002
LIN1_NYCCO (P08548) LINE-1 reverse transcriptase homolog               42  0.003
YTX2_XENLA (P14381) Transposon TX1 hypothetical 149 kDa protein ...    39  0.041
PUMA_PARUN (O61308) 227 kDa spindle- and centromere-associated p...    39  0.041

>ARP_ARATH (P45951) Apurinic endonuclease-redox protein
           (DNA-(apurinic or apyrimidinic site) lyase) (EC
           4.2.99.18)
          Length = 536

 Score =  584 bits (1506), Expect = e-166
 Identities = 288/458 (62%), Positives = 358/458 (77%), Gaps = 9/458 (1%)

Query: 52  EIERLRNDPSIVDTMTVQELRKTLKSIRVPAKGRKEDLLSTLKSFMDNNMGEQHPQIEEE 111
           E+  L++D   ++ MTVQELR TL+ + VP KGRK++L+STL+  MD+N+ +Q       
Sbjct: 86  EMGTLQDDRKEIEAMTVQELRSTLRKLGVPVKGRKQELISTLRLHMDSNLPDQKETSS-- 143

Query: 112 HGLLISSENTSVEVKTKKVD-EDHVDDINDNPEVFEHSRGKRRLKQSGSESETVKVTTKK 170
                S+ + SV +K K  + E+  +D   N E ++   G++R+KQS  ++   KV+ K 
Sbjct: 144 -----STRSDSVTIKRKISNREEPTEDECTNSEAYDIEHGEKRVKQSTEKNLKAKVSAKA 198

Query: 171 KLLVESDEVSDFKPS-RAKRRVSSDIVRVVSQSDEISTTTIPTEPWTVLAHKKPQKDWIA 229
               +   +   K   ++K   SS I   + +++EI ++   +EPWTVLAHKKPQKDW A
Sbjct: 199 IAKEQKSLMRTGKQQIQSKEETSSTISSELLKTEEIISSPSQSEPWTVLAHKKPQKDWKA 258

Query: 230 YNPKTMRPQPLTRDTKFVKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQE 289
           YNPKTMRP PL   TK VK+++WNVNGLR LLK E FSAL+LAQRE+FD+LCLQETKLQ 
Sbjct: 259 YNPKTMRPPPLPEGTKCVKVMTWNVNGLRGLLKFESFSALQLAQRENFDILCLQETKLQV 318

Query: 290 KDINEIKRQLIDGYENSFWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTA 349
           KD+ EIK+ LIDGY++SFW+CSVSKLGYSGTAIISRIKPLSVRYG G+S HDTEGR+VTA
Sbjct: 319 KDVEEIKKTLIDGYDHSFWSCSVSKLGYSGTAIISRIKPLSVRYGTGLSGHDTEGRIVTA 378

Query: 350 EFDTFYLICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEID 409
           EFD+FYLI  Y+PNSGDGLKRLSYR+ +WD +LSN++KELEK+KPVVLTGDLNCAHEEID
Sbjct: 379 EFDSFYLINTYVPNSGDGLKRLSYRIEEWDRTLSNHIKELEKSKPVVLTGDLNCAHEEID 438

Query: 410 IYNPAGNKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVGYTYWGYRHGGRKTNRGW 469
           I+NPAGNK+SAGFT EER+SF AN L +GFVDTFR+QHP VVGYTYWGYRHGGRKTN+GW
Sbjct: 439 IFNPAGNKRSAGFTIEERQSFGANLLDKGFVDTFRKQHPGVVGYTYWGYRHGGRKTNKGW 498

Query: 470 RLDYFLVSESIADKVHDSYILPDVMGSDHCPVGLIIKL 507
           RLDYFLVS+SIA  VHDSYILPD+ GSDHCP+GLI+KL
Sbjct: 499 RLDYFLVSQSIAANVHDSYILPDINGSDHCPIGLILKL 536


>EXOA_BACSU (P37454) Exodeoxyribonuclease (EC 3.1.11.2)
          Length = 252

 Score =  263 bits (673), Expect = 6e-70
 Identities = 129/262 (49%), Positives = 187/262 (71%), Gaps = 11/262 (4%)

Query: 247 VKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENS 306
           +KL+SWNVNGLRA+++   F  L   + ED D++CLQETK+Q+  ++     L     + 
Sbjct: 1   MKLISWNVNGLRAVMRKMDF--LSYLKEEDADIICLQETKIQDGQVD-----LQPEDYHV 53

Query: 307 FWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGD 366
           +W  +V K GYSGTA+ S+ +PL V YG+G+ +HD EGR++T EF+  +++  Y PNS  
Sbjct: 54  YWNYAVKK-GYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFVMTVYTPNSRR 112

Query: 367 GLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEE 426
           GL+R+ YR+ QW+ +L +Y+ EL++ KPV+L GDLN AH+EID+ NP  N+ +AGF+D+E
Sbjct: 113 GLERIDYRM-QWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKANRNNAGFSDQE 171

Query: 427 RKSFAANFLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRLDYFLVSESIADKVH 485
           R++F   FL  GFVD+FR  +PD+ G Y++W YR G R  N GWR+DYF+VSES+ +++ 
Sbjct: 172 REAFT-RFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDYFVVSESLKEQIE 230

Query: 486 DSYILPDVMGSDHCPVGLIIKL 507
           D+ I  DVMGSDHCPV LII +
Sbjct: 231 DASISADVMGSDHCPVELIINI 252


>APEA_DICDI (P51173) DNA-(apurinic or apyrimidinic site) lyase (EC
           4.2.99.18) (Class II
           apurinic/apyrimidinic(AP)-endonuclease)
          Length = 361

 Score =  245 bits (625), Expect = 2e-64
 Identities = 125/264 (47%), Positives = 180/264 (67%), Gaps = 11/264 (4%)

Query: 247 VKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENS 306
           +K++SWNV G +++L  +GF+  E  ++E+ DVLCLQETK+   +I   K Q+  GYE  
Sbjct: 105 MKIISWNVAGFKSVLS-KGFT--ECVEKENPDVLCLQETKINPSNIK--KDQMPKGYEYH 159

Query: 307 FWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGD 366
           F      + G+ GT ++++ KP ++ +G+GI+ HD EGR++T E+  FY++  YIPN+G 
Sbjct: 160 F--IEADQKGHHGTGVLTKKKPNAITFGIGIAKHDNEGRVITLEYVQFYIVNTYIPNAGT 217

Query: 367 -GLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDE 425
            GL+RL YR+ +WD     YL++L  TKP++  GDLN AH EID+ NP  NKKSAGFT E
Sbjct: 218 RGLQRLDYRIKEWDVDFQAYLEKLNATKPIIWCGDLNVAHTEIDLKNPKTNKKSAGFTIE 277

Query: 426 ERKSFAANFLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRLDYFLVSESIADKV 484
           ER SF +NFL +G+VD++R  +P   G YT+W Y  GGR  N GWRLDYF+VS+ + D +
Sbjct: 278 ERTSF-SNFLEKGYVDSYRHFNPGKEGSYTFWSYLGGGRSKNVGWRLDYFVVSKRLMDSI 336

Query: 485 HDS-YILPDVMGSDHCPVGLIIKL 507
             S +    VMGSDHCP+G+++ L
Sbjct: 337 KISPFHRTSVMGSDHCPIGVVVDL 360


>APE1_BOVIN (P23196) DNA-(apurinic or apyrimidinic site) lyase (EC
           4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN)
          Length = 317

 Score =  242 bits (618), Expect = 1e-63
 Identities = 121/262 (46%), Positives = 166/262 (63%), Gaps = 6/262 (2%)

Query: 247 VKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENS 306
           +K+ SWNV+GLRA +K +G   L+  + E  D+LCLQETK  E  +  ++ Q + G  + 
Sbjct: 61  LKICSWNVDGLRAWIKKKG---LDWVKEEAPDILCLQETKCSENKL-PVELQELSGLSHQ 116

Query: 307 FWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGD 366
           +W+    K GYSG  ++SR  PL V YG+G  +HD EGR++ AE+D F L+  Y+PN+G 
Sbjct: 117 YWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEYDAFVLVTAYVPNAGR 176

Query: 367 GLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEE 426
           GL RL YR  +WD +   +LK L   KP+VL GDLN AHEEID+ NP GNKK+AGFT +E
Sbjct: 177 GLVRLEYR-QRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQE 235

Query: 427 RKSFAANFLSRGFVDTFRRQHPDVV-GYTYWGYRHGGRKTNRGWRLDYFLVSESIADKVH 485
           R+ F     +    D+FR  +P+    YT+W Y    R  N GWRLDYFL+S+S+   + 
Sbjct: 236 RQGFGELLQAVPLTDSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSQSVLPALC 295

Query: 486 DSYILPDVMGSDHCPVGLIIKL 507
           DS I    +GSDHCP+ L + L
Sbjct: 296 DSKIRSKALGSDHCPITLYLAL 317


>APE1_HUMAN (P27695) DNA-(apurinic or apyrimidinic site) lyase (EC
           4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN)
           (REF-1 protein)
          Length = 317

 Score =  242 bits (617), Expect = 2e-63
 Identities = 133/316 (42%), Positives = 181/316 (57%), Gaps = 13/316 (4%)

Query: 198 VVSQSDEISTTTIPTEPWTVLAHKKPQKDWIAYNPKTMRPQPLTRDTKF-----VKLLSW 252
           V    DE+ T   P    +  A KK  K+     P      P  + +       +K+ SW
Sbjct: 9   VAEDGDELRTE--PEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSW 66

Query: 253 NVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENSFWTCSV 312
           NV+GLRA +K +G   L+  + E  D+LCLQETK  E  +   + Q + G  + +W+   
Sbjct: 67  NVDGLRAWIKKKG---LDWVKEEAPDILCLQETKCSENKL-PAELQELPGLSHQYWSAPS 122

Query: 313 SKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGDGLKRLS 372
            K GYSG  ++SR  PL V YG+G  +HD EGR++ AEFD+F L+  Y+PN+G GL RL 
Sbjct: 123 DKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLE 182

Query: 373 YRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEERKSFAA 432
           YR  +WD +   +LK L   KP+VL GDLN AHEEID+ NP GNKK+AGFT +ER+ F  
Sbjct: 183 YR-QRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE 241

Query: 433 NFLSRGFVDTFRRQHPDV-VGYTYWGYRHGGRKTNRGWRLDYFLVSESIADKVHDSYILP 491
              +    D+FR  +P+    YT+W Y    R  N GWRLDYFL+S S+   + DS I  
Sbjct: 242 LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRS 301

Query: 492 DVMGSDHCPVGLIIKL 507
             +GSDHCP+ L + L
Sbjct: 302 KALGSDHCPITLYLAL 317


>APE1_RAT (P43138) DNA-(apurinic or apyrimidinic site) lyase (EC
           4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN)
          Length = 316

 Score =  241 bits (615), Expect = 3e-63
 Identities = 127/295 (43%), Positives = 176/295 (59%), Gaps = 11/295 (3%)

Query: 219 AHKKPQKDWIAYNPKTMRPQP-----LTRDTKFVKLLSWNVNGLRALLKLEGFSALELAQ 273
           A KK +K+     P      P      +  +  +K+ SWNV+GLRA +K +G   L+  +
Sbjct: 27  AAKKTEKEAAGEGPVLYEDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKG---LDWVK 83

Query: 274 REDFDVLCLQETKLQEKDINEIKRQLIDGYENSFWTCSVSKLGYSGTAIISRIKPLSVRY 333
            E  D+LCLQETK  E  +   + Q + G  + +W+    K GYSG  ++SR  PL V Y
Sbjct: 84  EEAPDILCLQETKCSENKL-PAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSY 142

Query: 334 GLGISDHDTEGRLVTAEFDTFYLICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTK 393
           G+G  +HD EGR++ AEF++F L+  Y+PN+G GL RL YR  +WD +   +LK+L   K
Sbjct: 143 GIGEEEHDQEGRVIVAEFESFILVTAYVPNAGRGLVRLEYR-QRWDEAFRKFLKDLASRK 201

Query: 394 PVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDVV-G 452
           P+VL GDLN AHEEID+ NP GNKK+AGFT +ER+ F     +    D+FR  +P+    
Sbjct: 202 PLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYA 261

Query: 453 YTYWGYRHGGRKTNRGWRLDYFLVSESIADKVHDSYILPDVMGSDHCPVGLIIKL 507
           YT+W Y    R  N GWRLDYFL+S S+   + DS I    +GSDHCP+ L + L
Sbjct: 262 YTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL 316


>APE1_MOUSE (P28352) DNA-(apurinic or apyrimidinic site) lyase (EC
           4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN)
          Length = 316

 Score =  240 bits (613), Expect = 5e-63
 Identities = 121/262 (46%), Positives = 166/262 (63%), Gaps = 6/262 (2%)

Query: 247 VKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENS 306
           +K+ SWNV+GLRA +K +G   L+  + E  D+LCLQETK  E  +   + Q + G  + 
Sbjct: 60  LKICSWNVDGLRAWIKKKG---LDWVKEEAPDILCLQETKCSENKL-PAELQELPGLTHQ 115

Query: 307 FWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGD 366
           +W+    K GYSG  ++SR  PL V YG+G  +HD EGR++ AEF++F L+  Y+PN+G 
Sbjct: 116 YWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFVLVTAYVPNAGR 175

Query: 367 GLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEE 426
           GL RL YR  +WD +   +LK+L   KP+VL GDLN AHEEID+ NP GNKK+AGFT +E
Sbjct: 176 GLVRLEYR-QRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQE 234

Query: 427 RKSFAANFLSRGFVDTFRRQHPDVV-GYTYWGYRHGGRKTNRGWRLDYFLVSESIADKVH 485
           R+ F     +    D+FR  +P+    YT+W Y    R  N GWRLDYFL+S S+   + 
Sbjct: 235 RQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALC 294

Query: 486 DSYILPDVMGSDHCPVGLIIKL 507
           DS I    +GSDHCP+ L + L
Sbjct: 295 DSKIRSKALGSDHCPITLYLAL 316


>RRP1_DROME (P27864) Recombination repair protein 1 (DNA-(apurinic
           or apyrimidinic site) lyase) (EC 4.2.99.18)
          Length = 679

 Score =  224 bits (571), Expect = 4e-58
 Identities = 138/375 (36%), Positives = 200/375 (52%), Gaps = 25/375 (6%)

Query: 146 EHSRGKRRLKQSGSES-----------ETVKVTTKKKLLVESDEVSDFKPSRAKRRVSSD 194
           E + GK++ K +  E+           ET     +KK  V++++V D + +  + + +  
Sbjct: 317 EPAPGKKQKKSADKENGVVEEEAKPSTETKPAKGRKKAPVKAEDVEDIEEAAEESKPARG 376

Query: 195 IVRVVSQSDEISTTTIPTEPWTVLAHKKPQKDWIAYNPKTMRPQPLTRDTKF-VKLLSWN 253
             +  ++++E           T  A K   K  +  +        L  D +F +K+ SWN
Sbjct: 377 RKKAAAKAEEPDVDEESGSKTTKKAKKAETKTTVTLDKDAFA---LPADKEFNLKICSWN 433

Query: 254 VNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYENSFWTCSVS 313
           V GLRA LK +G   ++L   E+ D+ CLQETK     + E   +L  GY + +W C   
Sbjct: 434 VAGLRAWLKKDGLQLIDL---EEPDIFCLQETKCANDQLPEEVTRL-PGY-HPYWLCMPG 488

Query: 314 KLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFYLICGYIPNSGDGLKRLSY 373
             GY+G AI S+I P+ V YG+G  + D  GR++TAE++ FYLI  Y+PNSG  L  L  
Sbjct: 489 --GYAGVAIYSKIMPIHVEYGIGNEEFDDVGRMITAEYEKFYLINVYVPNSGRKLVNLEP 546

Query: 374 RVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAGNKKSAGFTDEERKSFAAN 433
           R+ +W+     Y+K+L+  KPVV+ GD+N +H  ID+ NP  N K+AGFT EER      
Sbjct: 547 RM-RWEKLFQAYVKKLDALKPVVICGDMNVSHMPIDLENPKNNTKNAGFTQEERDKM-TE 604

Query: 434 FLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRLDYFLVSESIADKVHDSYILPD 492
            L  GFVDTFR  +PD  G YT+W Y    R  N GWRLDY LVSE    KV +  I   
Sbjct: 605 LLGLGFVDTFRHLYPDRKGAYTFWTYMANARARNVGWRLDYCLVSERFVPKVVEHEIRSQ 664

Query: 493 VMGSDHCPVGLIIKL 507
            +GSDHCP+ +   +
Sbjct: 665 CLGSDHCPITIFFNI 679


>EXOA_STRPN (P21998) Exodeoxyribonuclease (EC 3.1.11.2)
          Length = 275

 Score =  197 bits (500), Expect = 7e-50
 Identities = 122/278 (43%), Positives = 159/278 (56%), Gaps = 20/278 (7%)

Query: 247 VKLLSWNVNGLRALLKLEGFSA------LELAQREDFDVLCLQETKLQEKDIN----EIK 296
           +KL+SWN++ L A L  +   A      L+    E+ D++ +QETKL  K       EI 
Sbjct: 1   MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQETKLSAKGPTKKHVEIL 60

Query: 297 RQLIDGYENSFWTCSV--SKLGYSGTAIISR--IKPLSVRYGLGI-SDHDTEGRLVTAEF 351
            +L  GYEN+ W  S   ++ GY+GT  + +  + P      +G  S  D EGR++T EF
Sbjct: 61  EELFPGYENT-WRSSQEPARKGYAGTMFLYKKELTPTISFPEIGAPSTMDLEGRIITLEF 119

Query: 352 DTFYLICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIY 411
           D F++   Y PN+GDGLKRL  R   WD   + YL EL+K KPV+ TGD N AH EID+ 
Sbjct: 120 DAFFVTQVYTPNAGDGLKRLEERQV-WDAKYAEYLAELDKEKPVLATGDYNVAHNEIDLA 178

Query: 412 NPAGNKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDV-VGYTYWGYRHGGRK-TNRGW 469
           NPA N++S GFTDEER  F  N L+ GF DTFR  H DV   YT+W  R    K  N GW
Sbjct: 179 NPASNRRSPGFTDEERAGF-TNLLATGFTDTFRHVHGDVPERYTWWAQRSKTSKINNTGW 237

Query: 470 RLDYFLVSESIADKVHDSYILPDVMGSDHCPVGLIIKL 507
           R+DY+L S  IADKV  S ++      DH P+ L I L
Sbjct: 238 RIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL 275


>EX3_SALTY (Q9Z612) Exodeoxyribonuclease III (EC 3.1.11.2)
           (Exonuclease III) (EXO III) (AP endonuclease VI)
          Length = 268

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 84/275 (30%), Positives = 142/275 (51%), Gaps = 33/275 (12%)

Query: 247 VKLLSWNVNGLRALL-KLEGFSALELAQREDFDVLCLQETKLQEK--DINEIKRQLIDGY 303
           +K +S+N+NGLRA   +LE      + ++   DV+ LQETK+ ++   + E+ +    GY
Sbjct: 1   MKFVSFNINGLRARPHQLEA-----IVEKHQPDVIGLQETKVHDEMFPLEEVAKL---GY 52

Query: 304 ENSFWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDT----FYLICG 359
            N F+     + G+ G A++++  P+SVR G      + + R++ AE  +      +I G
Sbjct: 53  -NVFYH---GQKGHYGVALLTKATPISVRRGFPDDGEEAQRRIIMAEIPSPLGNITVING 108

Query: 360 YIPNSGDGLKRLSYRV-TQWDPSLSNYLK-ELEKTKPVVLTGDLNCAHEEIDIYNPAGNK 417
           Y P        L +    Q+  +L NYL+ EL+   PV++ GD+N +  ++DI     N+
Sbjct: 109 YFPQGESRDHPLKFPAKAQFYQNLQNYLETELKCDNPVLIMGDMNISPTDLDIGIGEENR 168

Query: 418 K------SAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWR 470
           K         F  EER+ + +  L  G VDTFR+ +P  +  ++++ YR  G   NRG R
Sbjct: 169 KRWLRTGKCSFLPEERE-WMSRLLKWGLVDTFRQANPQTMDKFSWFDYRSKGFVDNRGLR 227

Query: 471 LDYFLVSESIADKVHDSYILPDVMG----SDHCPV 501
           +D  L S  +A++  ++ I  D+      SDH PV
Sbjct: 228 IDLLLASAPLAERCAETGIDYDIRSMEKPSDHAPV 262


>EX3_ECOLI (P09030) Exodeoxyribonuclease III (EC 3.1.11.2)
           (Exonuclease III) (EXO III) (AP endonuclease VI)
          Length = 268

 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 82/273 (30%), Positives = 141/273 (51%), Gaps = 29/273 (10%)

Query: 247 VKLLSWNVNGLRALL-KLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGYEN 305
           +K +S+N+NGLRA   +LE      + ++   DV+ LQETK+ + D+  ++     GY N
Sbjct: 1   MKFVSFNINGLRARPHQLEA-----IVEKHQPDVIGLQETKVHD-DMFPLEEVAKLGY-N 53

Query: 306 SFWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFY----LICGYI 361
            F+     + G+ G A++++  P++VR G    D + + R++ AE  +      +I GY 
Sbjct: 54  VFYH---GQKGHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYF 110

Query: 362 PNSGDGLKRLSYRV-TQWDPSLSNYLK-ELEKTKPVVLTGDLNCAHEEIDIYNPAGNKK- 418
           P        + +    Q+  +L NYL+ EL++  PV++ GD+N +  ++DI     N+K 
Sbjct: 111 PQGESRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKR 170

Query: 419 -----SAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRLD 472
                   F  EER+ +    +S G VDTFR  +P     ++++ YR  G   NRG R+D
Sbjct: 171 WLRTGKCSFLPEERE-WMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRID 229

Query: 473 YFLVSESIADKVHDSYILPDVMG----SDHCPV 501
             L S+ +A+   ++ I  ++      SDH PV
Sbjct: 230 LLLASQPLAECCVETGIDYEIRSMEKPSDHAPV 262


>APN2_SCHPO (P87175) DNA-(apurinic or apyrimidinic site) lyase 2 (EC
           4.2.99.18) (AP endonuclease 2) (Apurinic-apyrimidinic
           endonuclease 2)
          Length = 523

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 90/308 (29%), Positives = 143/308 (46%), Gaps = 53/308 (17%)

Query: 247 VKLLSWNVNGLRALLKLEGF----SALELAQREDFDVLCLQETKLQEKDINEIKRQLIDG 302
           +++LSWNVNG++       +    S  E+ Q    DV+C+QE K+Q KD    +  +++G
Sbjct: 1   MRILSWNVNGIQNPFNYFPWNKKNSYKEIFQELQADVICVQELKMQ-KDSFPQQYAVVEG 59

Query: 303 YENSFWTCSVSKLGYSGTAI-ISRIKPLSVRYGLGIS----------------DH----- 340
           ++ S++T    + GYSG    + +   + V+   GI+                +H     
Sbjct: 60  FD-SYFTFPKIRKGYSGVGFYVKKDVAIPVKAEEGITGILPVRGQKYSYSEAPEHEKIGF 118

Query: 341 -------------DTEGRLVTAEFDTFYLICGYIP-NSGDGLKRLSYRVTQWDPSLSNYL 386
                        D+EGR +  +F  F LI  Y P NSG+   RL YR   +  +L   +
Sbjct: 119 FPKDIDRKTANWIDSEGRCILLDFQMFILIGVYCPVNSGEN--RLEYRRAFYK-ALRERI 175

Query: 387 KEL--EKTKPVVLTGDLNCAHEEIDIYNPAGN-KKSAGFTDEERKSFAANFLSRG----F 439
           + L  E  + ++L GD+N     ID  +     ++S   +  E + +  + L        
Sbjct: 176 ERLIKEGNRKIILVGDVNILCNPIDTADQKDIIRESLIPSIMESRQWIRDLLLPSRLGLL 235

Query: 440 VDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRLDYFLVSESIADKVHDSYILPDVMGSDH 498
           +D  R QHP   G +T W  R   R TN G R+DY L +  +   V D+ I+ +VMGSDH
Sbjct: 236 LDIGRIQHPTRKGMFTCWNTRLNTRPTNYGTRIDYTLATPDLLPWVQDADIMAEVMGSDH 295

Query: 499 CPVGLIIK 506
           CPV L +K
Sbjct: 296 CPVYLDLK 303


>EX3_HAEIN (P44318) Exodeoxyribonuclease III (EC 3.1.11.2)
           (Exonuclease III) (EXO III)
          Length = 267

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 77/274 (28%), Positives = 135/274 (49%), Gaps = 31/274 (11%)

Query: 247 VKLLSWNVNGLRALL-KLEGFSALELAQREDFDVLCLQETKLQEKDIN-EIKRQLIDGYE 304
           +K +S+N+NGLRA   +LE      + ++   DV+ LQE K+ ++    EI   L  GY 
Sbjct: 1   MKFISFNINGLRARPHQLEA-----IIEKYQPDVIGLQEIKVADEAFPYEITENL--GYH 53

Query: 305 NSFWTCSVSKLGYSGTAIISRIKPLSVRYGLGISDHDTEGRLVTAEFDTFY----LICGY 360
                    + G+ G A++++ +P  +R G    + D + R++ A+ +T +    +I GY
Sbjct: 54  ----VFHHGQKGHYGVALLTKQEPKVIRRGFPTDNEDAQKRIIMADLETEFGLLTVINGY 109

Query: 361 IPNSGDGLKRLSYRVTQ-WDPSLSNYL-KELEKTKPVVLTGDLNCAHEEIDIYNPAGNKK 418
            P          +   + +   L  YL KE +K+ P+++ GD+N +  ++DI     N+K
Sbjct: 110 FPQGESRAHETKFPAKEKFYADLQQYLEKEHDKSNPILIMGDMNISPSDLDIGIGDENRK 169

Query: 419 ------SAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVG-YTYWGYRHGGRKTNRGWRL 471
                    F  EER ++       G  D+FR+ +P     ++++ YR  G   NRG R+
Sbjct: 170 RWLRTGKCSFLPEER-AWYQRLYDYGLEDSFRKLNPTANDKFSWFDYRSKGFDDNRGLRI 228

Query: 472 DYFLVSESIADKVHDSYILPDVMG----SDHCPV 501
           D+ LVS+ +A++  D  I  D+      SDH P+
Sbjct: 229 DHILVSQKLAERCVDVGIALDIRAMEKPSDHAPI 262


>APN2_YEAST (P38207) DNA-(apurinic or apyrimidinic site) lyase 2 (EC
           4.2.99.18) (AP endonuclease 2) (Apurinic-apyrimidinic
           endonuclease 2)
          Length = 520

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 86/344 (25%), Positives = 135/344 (39%), Gaps = 92/344 (26%)

Query: 247 VKLLSWNVNGLRALLKLEGFSALELAQREDFD-----VLCLQETKLQEKDINEIKRQLID 301
           ++ L++NVNG+R     + FS +  + R  FD     ++  QE K ++  I++  R  +D
Sbjct: 17  IRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFFRADIITFQELKTEKLSISKWGR--VD 74

Query: 302 GYENSFWTCSVSKLGYSGTAIISRIK----PL---------------------------- 329
           G+  SF +   ++ GYSG     RI     PL                            
Sbjct: 75  GFY-SFISIPQTRKGYSGVGCWIRIPEKNHPLYHALQVVKAEEGITGYLTIKNGKHSAIS 133

Query: 330 ---SVRYGLGISDH-------------DTEGRLVTAEFDT-FYLICGYIPNSGDGLKRLS 372
               V  G+G  D              D+EGR V  E      +I  Y P + +  +   
Sbjct: 134 YRNDVNQGIGGYDSLDPDLDEKSALELDSEGRCVMVELACGIVIISVYCPANSNSSEEGE 193

Query: 373 YRVTQWDPSLSNYLKELEKT-KPVVLTGDLNCAHEEID-----------IYNPAGNKK-S 419
               ++   L   ++ L+K  K +VL GD+N   + ID           I +P G  K  
Sbjct: 194 MFRLRFLKVLLRRVRNLDKIGKKIVLMGDVNVCRDLIDSADTLEQFSIPITDPMGGTKLE 253

Query: 420 AGFTDEERK-------------------SFAANFLSRGF-VDTFR--RQHPDVVGYTYWG 457
           A + D+  +                   S   +   RG  +DT R  +    +  YT W 
Sbjct: 254 AQYRDKAIQFIINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLIQTRNRLKMYTVWN 313

Query: 458 YRHGGRKTNRGWRLDYFLVSESIADKVHDSYILPDVMGSDHCPV 501
                R +N G R+D+ LVS  +   +  + ILPD++GSDHCPV
Sbjct: 314 MLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDILGSDHCPV 357


>LIN1_HUMAN (P08547) LINE-1 reverse transcriptase homolog
          Length = 1259

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 59/275 (21%), Positives = 117/275 (42%), Gaps = 45/275 (16%)

Query: 241 TRDTKFVKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLI 300
           T     + +L+ NVNGL A +K    +     + +D  V C+QET L  +D + +K   I
Sbjct: 1   TGSNSHITILTLNVNGLNAPIKRHRLA--NWIKSQDPSVCCIQETHLTCRDTHRLK---I 55

Query: 301 DGYENSFWTCSVSKLGYSGTAII----SRIKPLSVRYGLGISDHDTEGRLV----TAEFD 352
            G+ N +      K   +G AI+    +  KP  ++        D EG  +    + + +
Sbjct: 56  KGWRNIYQANGKQK--KAGVAILVSDKTDFKPTKIK-------RDKEGHYIMVKGSIQQE 106

Query: 353 TFYLICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYN 412
              ++  Y PN+  G  R   +V      LS+  ++L+     ++ GD N     +D   
Sbjct: 107 ELTILNIYAPNT--GAPRFIKQV------LSDLQRDLD--SHTIIMGDFNTPLSTLD--- 153

Query: 413 PAGNKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVGYTYWGYRHGGRKTNRGWRLD 472
               + +    +++ +   +       +D +R  HP    YT++   H     +   + D
Sbjct: 154 ----RSTRQKINKDIQELNSALHQADLIDIYRTLHPKSTEYTFFSAPH-----HTYSKTD 204

Query: 473 YFLVSESIADKVHDSYILPDVMGSDHCPVGLIIKL 507
           + L S+++  K   + I+ + + SDH  + L +++
Sbjct: 205 HILGSKTLLSKCKRTEIITNCL-SDHSAIKLELRI 238


>DH47_ARATH (P31168) Dehydrin COR47 (Cold-induced COR47 protein)
          Length = 265

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 34/148 (22%), Positives = 63/148 (41%), Gaps = 9/148 (6%)

Query: 84  GRKEDLL-----STLKSFMDNNMGEQHPQIEEEHGLLISSENTSVEVKTKKVDEDHVDDI 138
           G+KE+ +     +TL+S  D+      P++  EH  +  ++ T +E   +K +ED     
Sbjct: 39  GKKEEEVKPQETTTLESEFDHKAQISEPELAAEHEEVKENKITLLEELQEKTEEDE---- 94

Query: 139 NDNPEVFEHSRGKRRLKQSGSESETVKVTTKKKLLVESDEVSDFKPSRAKRRVSSDIVRV 198
            + P V E          S S+ E  +   KKK +VE +E       + K ++     + 
Sbjct: 95  ENKPSVIEKLHRSNSSSSSSSDEEGEEKKEKKKKIVEGEEDKKGLVEKIKEKLPGHHDKT 154

Query: 199 VSQSDEISTTTIPTEPWTVLAHKKPQKD 226
                 +STT       +V+ H  P+++
Sbjct: 155 AEDDVPVSTTIPVPVSESVVEHDHPEEE 182


>YKQ0_CAEEL (P34305) Putative ATP-dependent RNA helicase C06E1.10 in
           chromosome III (EC 3.6.1.-)
          Length = 1148

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 14/153 (9%)

Query: 79  RVPAKGRKEDLLSTLKSFMDNNMGEQHPQIEEEHGLLISSENTSVEVKTKKVDEDHVDD- 137
           +  AK  ++D   T     D+    +  + EEE    I     +VEVK + +D D VD+ 
Sbjct: 126 KTEAKRTQQDYYPT-----DDESSSEEEEEEEEGDNDIEDAGNTVEVKIEPIDLDDVDEA 180

Query: 138 INDNPEVFEHSRGKRRLKQSGSESE------TVKVTTKKKLLVESDEVSDFKPSRAKRRV 191
           I+ NPE        +R     S++E      T  V  +KK++VE  +  + + SRA+  +
Sbjct: 181 IDGNPETNLDQIVVKREDDEESDNEDILALPTTTVINRKKVIVERSK--EIQKSRAELPI 238

Query: 192 SSDIVRVVSQSDEISTTTIPTEPWTVLAHKKPQ 224
            ++ +R+V   +E   T +  E  +    + PQ
Sbjct: 239 FAEEMRIVEAINENLVTVVCGETGSGKTTQIPQ 271


>LIN1_NYCCO (P08548) LINE-1 reverse transcriptase homolog
          Length = 1260

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 57/263 (21%), Positives = 98/263 (36%), Gaps = 44/263 (16%)

Query: 244 TKFVKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINEIKRQLIDGY 303
           +K + + S NVNGL   LK    +  +  Q+   D+ C+QE+ L  KD   +K   + G+
Sbjct: 4   SKGLSIFSINVNGLNCPLKRHRLA--DWIQKLKPDICCIQESHLTLKDKYRLK---VKGW 58

Query: 304 ENSFWTCSVSKLGYSGTAIISR----IKPLSVRYGLGISDHDTEGRLV----TAEFDTFY 355
            + F      K   +G AI+       KP  +R        D +G  +      ++D   
Sbjct: 59  SSIFQANGKQKK--AGIAILFADAIGFKPTKIR-------KDKDGHFIFVKGNTQYDEIS 109

Query: 356 LICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYNPAG 415
           +I  Y PN           + +    +SN +         ++ GD N     +D      
Sbjct: 110 IINIYAPNHN-----APQFIRETLTDMSNLISSTS-----IVVGDFNTPLAVLD------ 153

Query: 416 NKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVGYTYWGYRHGGRKTNRGWRLDYFL 475
            + S     +E     +        D +R  HP+   YT++   HG        ++D+ L
Sbjct: 154 -RSSKKKLSKEILDLNSTIQHLDLTDIYRTFHPNKTEYTFFSSAHGTYS-----KIDHIL 207

Query: 476 VSESIADKVHDSYILPDVMGSDH 498
             +S   K     I+P +    H
Sbjct: 208 GHKSNLSKFKKIEIIPCIFSDHH 230


>YTX2_XENLA (P14381) Transposon TX1 hypothetical 149 kDa protein
           (ORF 2)
          Length = 1308

 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 17/137 (12%)

Query: 353 TFYLICGYIPNSGDGLKRLSYRVTQWDPSLSNYLKELEKTKPVVLTGDLNCAHEEIDIYN 412
           T+ L+  Y P +G    R          SLS Y++ ++  + +++ GD N   +  D   
Sbjct: 103 TYNLMNVYAPTTGPERARFF-------ESLSAYMETIDSDEALIIGGDFNYTLDARDRNV 155

Query: 413 PAGNKKSAGFTDEERKSFAANFLSRGFVDTFRRQHPDVVGYTYWGYRHGGRKTNRGWRLD 472
           P    K    ++   +   A+F     VD +R Q+P+ V +TY   R G    +   R+D
Sbjct: 156 P----KKRDSSESVLRELIAHF---SLVDVWREQNPETVAFTYVRVRDGHVSQS---RID 205

Query: 473 YFLVSESIADKVHDSYI 489
              +S  +  +   S I
Sbjct: 206 RIYISSHLMSRAQSSTI 222


>PUMA_PARUN (O61308) 227 kDa spindle- and centromere-associated
            protein (PUMA1)
          Length = 1955

 Score = 38.5 bits (88), Expect = 0.041
 Identities = 66/305 (21%), Positives = 122/305 (39%), Gaps = 49/305 (16%)

Query: 14   MLPFVEEKKDMKLNKGLEASPGSKKHVIKGNDANSYSIEIERLRNDPSIVDTMTVQELRK 73
            M   +EE K  +     EA+   +KH I  N++     EIER+R+D         ++++K
Sbjct: 944  MEKMLEEAKHRETVLREEATEWEEKHDIISNESLKLRNEIERIRSDAE-------EDIQK 996

Query: 74   TLKSIRVPAKGRK--EDLLSTLKSFMDNNMGEQHPQIEEEHGLLISSENTSVEVKTKKVD 131
              K + +     K  E +  TL+S           Q+   +   ++S NT++  +T K+ 
Sbjct: 997  WKKDVHMAQNELKNLERVCETLRS-----------QLTAAND-RVASLNTTINEQTSKIR 1044

Query: 132  EDHVDDINDNPEVFEHSRGKRRLKQSGSESETVKVTTKKKLLVESDEVSDFKPSRAKRRV 191
            E     +N +    E      R   S  E++    T + +   E + +   +  ++K  +
Sbjct: 1045 E-----LNSHEHRLEEDLADSRATSSAIENDLGNATGRLRSSEEHNAILQSENRKSKTEI 1099

Query: 192  SS-----DIVRVVSQSDE----------ISTTTIPTEPWTVLAHKKPQKDWIA--YNPKT 234
             +     D +    +S E          + TTTI  E    +   + + D +   Y  KT
Sbjct: 1100 EALKHQIDTIMNTKESCESEVERLKKKIVQTTTITKEQNEKIEKLRIEHDHLERDYREKT 1159

Query: 235  MRPQPLTRDTKFVKLLSWNVNGLRALLKLEGFSALELAQREDFDVLCLQETKLQEKDINE 294
                 L    K  +L    VN  RA  +L+ FS   +    + + +  +  KL +K++  
Sbjct: 1160 KEVDRLKEVEKTFEL---KVN--RARQELDEFSKKLIVTETERNAISGEAQKL-DKEVQL 1213

Query: 295  IKRQL 299
            +K QL
Sbjct: 1214 VKEQL 1218


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.315    0.134    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,399,676
Number of Sequences: 164201
Number of extensions: 2711351
Number of successful extensions: 6335
Number of sequences better than 10.0: 75
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 6242
Number of HSP's gapped (non-prelim): 98
length of query: 507
length of database: 59,974,054
effective HSP length: 115
effective length of query: 392
effective length of database: 41,090,939
effective search space: 16107648088
effective search space used: 16107648088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)