BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0263.11
(526 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DSOR_DROME (Q24324) Dual specificity mitogen-activated protein k... 204 5e-52
MPK5_RAT (Q62862) Dual specificity mitogen-activated protein kin... 181 4e-45
MPK2_HUMAN (P36507) Dual specificity mitogen-activated protein k... 178 3e-44
MPK2_MOUSE (Q63932) Dual specificity mitogen-activated protein k... 177 6e-44
MPK2_CYPCA (Q90321) Dual specificity mitogen-activated protein k... 177 8e-44
MPK2_CHICK (Q90891) Dual specificity mitogen-activated protein k... 177 8e-44
BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.1.-) (MAPK kinas... 177 8e-44
STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7... 176 1e-43
MPK2_RAT (P36506) Dual specificity mitogen-activated protein kin... 176 2e-43
MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.1.-) 174 4e-43
MPK5_HUMAN (Q13163) Dual specificity mitogen-activated protein k... 169 1e-41
MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.1.-) 168 3e-41
PBS2_YEAST (P08018) Polymyxin B resistance protein kinase (EC 2.... 167 6e-41
MPK6_HUMAN (P52564) Dual specificity mitogen-activated protein k... 166 2e-40
MPK6_MOUSE (P70236) Dual specificity mitogen-activated protein k... 165 2e-40
WIS1_SCHPO (P33886) Protein kinase wis1 (EC 2.7.1.-) (Protein ki... 164 5e-40
MPK3_MOUSE (O09110) Dual specificity mitogen-activated protein k... 164 7e-40
MPK3_HUMAN (P46734) Dual specificity mitogen-activated protein k... 161 3e-39
SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.1.-) 160 8e-39
MPK2_XENLA (Q07192) Dual specificity mitogen-activated protein k... 160 8e-39
>DSOR_DROME (Q24324) Dual specificity mitogen-activated protein
kinase kinase dSOR1 (EC 2.7.1.-) (Downstream of RAF)
(MAPKK)
Length = 393
Score = 204 bits (519), Expect = 5e-52
Identities = 126/312 (40%), Positives = 174/312 (55%), Gaps = 31/312 (9%)
Query: 81 EKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRT 139
EK ++ G +GSG VV + H H I+A K I++ K ++Q+L E++
Sbjct: 74 EKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKV 133
Query: 140 LCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLL 199
L E + +V F+GAFY+ G+ISI +EYMDGGSL IL++ RIPE IL + +L
Sbjct: 134 LHECN-FPHIVGFYGAFYS--DGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVL 190
Query: 200 HGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSP 259
GLSYL ++HRD+KP+N+LVN GE KI DFG+S L S M +FVGT +YMSP
Sbjct: 191 KGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDS--MANSFVGTRSYMSP 248
Query: 260 ERIRNESYSYPADIWSLGLALLECGTGEFPY--------------TANEGP--------- 296
ER++ YS +DIWSLGL+L+E G +P A E
Sbjct: 249 ERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAM 308
Query: 297 --VNLMLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVE 354
L+ I+++P P + FS EF F+D CL+K PD R + LL HP+I K E E
Sbjct: 309 AIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEE 368
Query: 355 VDLAGYVRSVFD 366
VD++G+V D
Sbjct: 369 VDISGWVCKTMD 380
>MPK5_RAT (Q62862) Dual specificity mitogen-activated protein kinase
kinase 5 (EC 2.7.1.-) (MAP kinase kinase 5) (MAPKK 5)
(MAPK/ERK kinase 5)
Length = 448
Score = 181 bits (459), Expect = 4e-45
Identities = 104/269 (38%), Positives = 164/269 (60%), Gaps = 17/269 (6%)
Query: 89 REMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINI-FEKEKRQQLLTEIRTLCEAPCYQ 147
+++R +G G V +A H+P +I+A+K I + E ++Q+++E+ L +
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSY 223
Query: 148 GLVEFHGAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHG 207
++ F+GAF+ + +ISI E+MDGGSL D+ RK IPE +L + ++ GL+YL
Sbjct: 224 -IIGFYGAFFVEN--RISICTEFMDGGSL-DVYRK---IPEHVLGRIAVAVVKGLTYLWS 276
Query: 208 VRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESY 267
++ ++HRD+KP+N+LVN G+ K+ DFG+S L +S+A T+VGT YM+PERI E Y
Sbjct: 277 LK-ILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQY 333
Query: 268 SYPADIWSLGLALLECGTGEFPY---TANEG---PVNLMLQILDDPSPSPSKQTFSPEFC 321
+D+WSLG++ +E G FPY N+G P+ L+ I+D+ SP FS F
Sbjct: 334 GIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFV 393
Query: 322 SFIDACLQKDPDVRPTAEQLLFHPFITKY 350
FI C++K P RP E+L+ HPFI ++
Sbjct: 394 HFITQCMRKQPKERPAPEELMGHPFIVQF 422
>MPK2_HUMAN (P36507) Dual specificity mitogen-activated protein
kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
(MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
(MEK2)
Length = 400
Score = 178 bits (451), Expect = 3e-44
Identities = 113/313 (36%), Positives = 169/313 (53%), Gaps = 55/313 (17%)
Query: 97 IGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRTL--CEAPCYQGLVEFH 153
+G+G VV + H P I+A K I++ K R Q++ E++ L C +P +V F+
Sbjct: 78 LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY---IVGFY 134
Query: 154 GAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVH 213
GAFY+ G+ISI +E+MDGGSL +L++ +RIPE IL + +L GL+YL ++H
Sbjct: 135 GAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMH 192
Query: 214 RDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADI 273
RD+KP+N+LVN +GE K+ DFG+S L S M +FVGT +YM+PER++ YS +DI
Sbjct: 193 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMAPERLQGTHYSVQSDI 250
Query: 274 WSLGLALLECGTGEFP-----------------YTANEG--------------PVN---- 298
WS+GL+L+E G +P EG PV+
Sbjct: 251 WSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGM 310
Query: 299 ----------LMLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFIT 348
L+ I+++P P F+P+F F++ CL K+P R + L H FI
Sbjct: 311 DSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIK 370
Query: 349 KYETVEVDLAGYV 361
+ E EVD AG++
Sbjct: 371 RSEVEEVDFAGWL 383
>MPK2_MOUSE (Q63932) Dual specificity mitogen-activated protein
kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
(MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
(MEK2)
Length = 401
Score = 177 bits (449), Expect = 6e-44
Identities = 112/314 (35%), Positives = 168/314 (52%), Gaps = 56/314 (17%)
Query: 97 IGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRTL--CEAPCYQGLVEFH 153
+G+G VV +A H P I+A K I++ K R Q++ E++ L C +P +V F+
Sbjct: 78 LGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQIIRELQVLHECNSPY---IVGFY 134
Query: 154 GAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVH 213
GAFY+ G+ISI +E+MDGGSL +L++ +RIPE IL + +L GL+YL ++H
Sbjct: 135 GAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMH 192
Query: 214 RDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADI 273
RD+KP+N+LVN +GE K+ DFG+S L S M +FVGT +YMSPER++ YS +DI
Sbjct: 193 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDI 250
Query: 274 WSLGLALLECGTGEFP------------------------------------------YT 291
WS+GL+L+E G +P +
Sbjct: 251 WSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHG 310
Query: 292 ANEGPVNLMLQILD----DPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFI 347
+ P + ++LD +P P FS +F F++ CL K+P R + L+ H FI
Sbjct: 311 MDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFI 370
Query: 348 TKYETVEVDLAGYV 361
+ E EVD AG++
Sbjct: 371 KRSEGEEVDFAGWL 384
>MPK2_CYPCA (Q90321) Dual specificity mitogen-activated protein
kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
(MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
(MEK2)
Length = 397
Score = 177 bits (448), Expect = 8e-44
Identities = 110/313 (35%), Positives = 165/313 (52%), Gaps = 55/313 (17%)
Query: 97 IGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRTL--CEAPCYQGLVEFH 153
+G+G VV + H P ++A K I++ K R Q++ E++ L C +P +V F+
Sbjct: 75 LGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY---IVGFY 131
Query: 154 GAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVH 213
GAFY+ G+ISI +E+MDGGSL +L++ RRIPE IL + +L GL YL ++H
Sbjct: 132 GAFYS--DGEISICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLVYLREKHQIMH 189
Query: 214 RDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADI 273
RD+KP+N+LVN +GE K+ DFG+S L S M +FVGT +YMSPER++ YS +D+
Sbjct: 190 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDV 247
Query: 274 WSLGLALLECGTGEFP-----------------------------------------YTA 292
WS+GL+L+E G FP +
Sbjct: 248 WSMGLSLVELAIGRFPIPPPDAKELEAIFGRPVLDKGGAEGHSMSPRQRPPGRPVSGHGM 307
Query: 293 NEGPVNLMLQILD----DPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFIT 348
+ P + ++LD +P P F+ +F F+ CL K+P R + L+ H FI
Sbjct: 308 DSRPAMAIFELLDYIVNEPPPKLPHGVFTTDFEEFVMKCLMKNPADRADLKMLMGHTFIK 367
Query: 349 KYETVEVDLAGYV 361
+ E EVD AG++
Sbjct: 368 RAEVEEVDFAGWM 380
>MPK2_CHICK (Q90891) Dual specificity mitogen-activated protein
kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
(MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2)
(MEK2)
Length = 398
Score = 177 bits (448), Expect = 8e-44
Identities = 110/313 (35%), Positives = 167/313 (53%), Gaps = 55/313 (17%)
Query: 97 IGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRTL--CEAPCYQGLVEFH 153
+G+G VV + H P I+A K I++ K R Q++ E++ L C +P +V F+
Sbjct: 76 LGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY---IVGFY 132
Query: 154 GAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVH 213
GAFY+ G+ISI +E+MDGGSL +L++ +RIPE IL + +L GL+YL ++H
Sbjct: 133 GAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMH 190
Query: 214 RDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADI 273
RD+KP+N+LVN +GE K+ DFG+S L S M +FVGT +YMSPER++ YS +DI
Sbjct: 191 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDI 248
Query: 274 WSLGLALLECGTGEFP-----------------------------------------YTA 292
WS+GL+L+E G +P +
Sbjct: 249 WSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAEGESHSVSPWARPPGRPISGHGM 308
Query: 293 NEGPVNLMLQILD----DPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFIT 348
+ P + ++LD +P P F+ +F F++ CL K+P R + L+ H FI
Sbjct: 309 DSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADLKMLMNHTFIK 368
Query: 349 KYETVEVDLAGYV 361
+ E EVD AG++
Sbjct: 369 RSEVEEVDFAGWL 381
>BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.1.-) (MAPK kinase)
(MAPKK)
Length = 340
Score = 177 bits (448), Expect = 8e-44
Identities = 113/314 (35%), Positives = 181/314 (56%), Gaps = 33/314 (10%)
Query: 58 ELGLQKCSSSSRSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRII 117
E +++C+ +R D D+S + + +G G A+ + KHR I
Sbjct: 42 EAFMEQCAHMNRRPAWISDLDNSS---------LEVVRHLGEGNGG----AVSLVKHRNI 88
Query: 118 ALKKINIF---EKEKRQQLLTEIRTL--CEAPCYQGLVEFHGAFYTPDSGQISIALEYMD 172
+ + ++ + + ++Q+L E+ L C +P +V F+GAF ++ IS+ +EYMD
Sbjct: 89 FMARKTVYVGSDSKLQKQILRELGVLHHCRSPY---IVGFYGAFQYKNN--ISLCMEYMD 143
Query: 173 GGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKIT 232
GSL ILR+ IP IL + ++ GL YL+ V H++HRD+KP+N++VN +GE K+
Sbjct: 144 CGSLDAILREGGPIPLDILGKIINSMVKGLIYLYNVLHIIHRDLKPSNVVVNSRGEIKLC 203
Query: 233 DFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADIWSLGLALLECGTGEFPYTA 292
DFG+S L +SVA TFVGT TYMSPERIR Y+ +DIWSLG++++E T E P++
Sbjct: 204 DFGVSGELVNSVAQ--TFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWSF 261
Query: 293 NE-----GPVNLMLQIL-DDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPF 346
+ G ++L+ I+ ++P PS +F + F+DACL KDP +R + +QL P+
Sbjct: 262 SNIDDSIGILDLLHCIVQEEPPRLPS--SFPEDLRLFVDACLHKDPTLRASPQQLCAMPY 319
Query: 347 ITKYETVEVDLAGY 360
+ + VDLA +
Sbjct: 320 FQQALMINVDLASW 333
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC
2.7.1.37)
Length = 515
Score = 176 bits (446), Expect = 1e-43
Identities = 119/363 (32%), Positives = 193/363 (52%), Gaps = 32/363 (8%)
Query: 24 STSSTLDPCDDSYTLSDGGTVNLLSRSYGVYNINELGLQKCSSSSRSVDESHDSDHSE-K 82
ST +D +++ LS T + S G+ NI + S S ++ES ++ K
Sbjct: 115 STPCIIDAYSNNFGLSPSSTNSTPSTIQGLSNIATPVENEHSISLPPLEESLSPAAADLK 174
Query: 83 TYRCGS--------REMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINIFEKEKR--QQ 132
G+ +++ G IG+G S V +A+H+P +I+A K I + + Q
Sbjct: 175 DTLSGTSNGNYIQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQ 234
Query: 133 LLTEIRTLCEAPCYQGLVEFHGAFYTPD-SGQISIALEYMDGGSLADILRKHRRIP---- 187
L+ E+ + ++ ++ F+GA+Y + +I I +EY D GSL IL ++R
Sbjct: 235 LVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGT 294
Query: 188 ---------EPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISA 238
E +S + +L+GL +L+ ++HRDIKP+N+L+N KG+ K+ DFG+S
Sbjct: 295 VSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSK 354
Query: 239 GLESSVAMCATFVGTVTYMSPERIRNESYSYPADIWSLGLALLECGTGEFPYTAN----E 294
L +S+A TFVGT TYMSPERI+ YS D+WSLGL ++E TGEFP + +
Sbjct: 355 KLINSIA--DTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPD 412
Query: 295 GPVNLMLQILDDPSPS-PSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETV 353
G ++L+ +I+++PSP P + +S E F++ C K+ R + +LL H I KY +
Sbjct: 413 GILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSP 472
Query: 354 EVD 356
D
Sbjct: 473 SKD 475
>MPK2_RAT (P36506) Dual specificity mitogen-activated protein kinase
kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2)
(ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2)
Length = 400
Score = 176 bits (445), Expect = 2e-43
Identities = 111/313 (35%), Positives = 167/313 (52%), Gaps = 55/313 (17%)
Query: 97 IGSGASSVVQRAIHIPKHRIIALKKINIFEKEK-RQQLLTEIRTL--CEAPCYQGLVEFH 153
+G+G VV +A H P I+A K I++ K R Q++ E++ L C +P +V F+
Sbjct: 78 LGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPY---IVGFY 134
Query: 154 GAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVH 213
GAFY+ G+ISI +E+MDGGSL +L++ +RIPE IL + +L GL+YL ++H
Sbjct: 135 GAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMH 192
Query: 214 RDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADI 273
RD+KP+N+LVN +GE K+ DFG+S L S M +FVGT +YMSPER++ YS +DI
Sbjct: 193 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDI 250
Query: 274 WSLGLALLECGTGEFP-----------------------------------------YTA 292
WS+GL+L+E G +P +
Sbjct: 251 WSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGM 310
Query: 293 NEGPVNLMLQILD----DPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFIT 348
+ P + ++LD +P P FS +F F++ CL K+P R + L H FI
Sbjct: 311 DSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIK 370
Query: 349 KYETVEVDLAGYV 361
+ E +VD AG++
Sbjct: 371 RSEGEDVDFAGWL 383
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.1.-)
Length = 506
Score = 174 bits (442), Expect = 4e-43
Identities = 114/306 (37%), Positives = 171/306 (55%), Gaps = 27/306 (8%)
Query: 81 EKTYRCG--SREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINIF--EKEKRQQLLTE 136
E+ +R G E+ G +G GA V + ++ ALK IN + E ++Q+ E
Sbjct: 202 EEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRE 261
Query: 137 IRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGSLA----DILRKHRRIPEPILS 192
++ ++ +V+++G F S I IA+EYM G SL ++L++ RI E ++
Sbjct: 262 LQ-FNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIG 320
Query: 193 SMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVG 252
+ + +L GLSYLH R ++HRDIKP N+L+N KGE K+ DFG+S +S+AM TF G
Sbjct: 321 KIAESVLRGLSYLHE-RKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAM--TFTG 377
Query: 253 TVTYMSPERIRNESYSYPADIWSLGLALLECGTGEFPY-----TANEGPVNLMLQIL--- 304
T YM+PERI+ + YS D+WSLGL LLE G FP+ T N P+ L+ IL
Sbjct: 378 TSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFS 437
Query: 305 ----DDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVEVDLAGY 360
D+P S +S F SFID CL+KD RP+ Q+L HP+I +V++ +
Sbjct: 438 PQLKDEPELDIS---WSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERF 494
Query: 361 VRSVFD 366
V+ ++
Sbjct: 495 VKKCWE 500
>MPK5_HUMAN (Q13163) Dual specificity mitogen-activated protein
kinase kinase 5 (EC 2.7.1.-) (MAP kinase kinase 5)
(MAPKK 5) (MAPK/ERK kinase 5)
Length = 438
Score = 169 bits (429), Expect = 1e-41
Identities = 99/266 (37%), Positives = 161/266 (60%), Gaps = 21/266 (7%)
Query: 89 REMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINI-FEKEKRQQLLTEIRTLCEAPCYQ 147
+++R +G G V +A H+P +I+A+K I + E ++Q+++E+ L +
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSY 223
Query: 148 GLVEFHGAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKLLHGLSYLHG 207
++ F+GAF+ + +ISI E+MDGGSL D+ RK +PE +L + ++ GL+YL
Sbjct: 224 -IIGFYGAFFVEN--RISICTEFMDGGSL-DVYRK---MPEHVLGRIAVAVVKGLTYLWS 276
Query: 208 VRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESY 267
++ ++HRD+KP+N+LVN +G+ K+ DFG+S L +S+A T+VGT YM+PERI E Y
Sbjct: 277 LK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQY 333
Query: 268 SYPADIWSLGLALLECGTGEFPYTANEG---PVNLMLQILDDPSPSPSKQTFSPEFCSFI 324
+D+WSLG++ +E N+G P+ L+ I+D+ SP FS F FI
Sbjct: 334 GIHSDVWSLGISFMEI-------QKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Query: 325 DACLQKDPDVRPTAEQLLFHPFITKY 350
C++K P RP E+L+ HPFI ++
Sbjct: 387 TQCMRKQPKERPAPEELMGHPFIVQF 412
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.1.-)
Length = 508
Score = 168 bits (426), Expect = 3e-41
Identities = 118/328 (35%), Positives = 177/328 (52%), Gaps = 35/328 (10%)
Query: 63 KCSSSSRSVDESH-------DSDH-SEKTYRCGSREMRI--FGAIGSGASSVVQRAIHIP 112
K SS +S ES+ D D E ++ + + RI G +G GA V +
Sbjct: 183 KSSSQPKSSSESYIDLNSVRDVDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKN 242
Query: 113 KHRIIALKKINIF--EKEKRQQLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEY 170
+I ALK IN + E ++Q+ E++ + + +V ++G F ++ I IA+EY
Sbjct: 243 GSKIFALKVINTLNTDPEYQKQIFRELQ-FNRSFQSEYIVRYYGMFTDDENSSIYIAMEY 301
Query: 171 MDGGSL----ADILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLK 226
M G SL ++L + RI E +L + + +L GLSYLH + ++HRDIKP N+L+N
Sbjct: 302 MGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHE-KKVIHRDIKPQNILLNEN 360
Query: 227 GEPKITDFGISAGLESSVAMCATFVGTVTYMSPERIRNESYSYPADIWSLGLALLECGTG 286
G+ K+ DFG+S +S+A TF GT YM+PERI+ + YS +D+WSLGL +LE G
Sbjct: 361 GQVKLCDFGVSGEAVNSLA--TTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANG 418
Query: 287 EFP-----YTANEGPVNLMLQIL-------DDPSPSPSKQTFSPEFCSFIDACLQKDPDV 334
+FP AN P L++ IL D+P S +SP F SFID CL+KD
Sbjct: 419 KFPCSSEKMAANIAPFELLMWILTFTPELKDEPE---SNIIWSPSFKSFIDYCLKKDSRE 475
Query: 335 RPTAEQLLFHPFITKYETVEVDLAGYVR 362
RP+ Q++ HP+I V++ +VR
Sbjct: 476 RPSPRQMINHPWIKGQMKKNVNMEKFVR 503
>PBS2_YEAST (P08018) Polymyxin B resistance protein kinase (EC
2.7.1.-)
Length = 668
Score = 167 bits (423), Expect = 6e-41
Identities = 106/313 (33%), Positives = 171/313 (53%), Gaps = 26/313 (8%)
Query: 63 KCSSSSRSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKI 122
K S SS+ +D S+ S R E+ +G G V + +H P + I+A K++
Sbjct: 337 KLSLSSKGIDFSNGSSS-----RITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEV 391
Query: 123 NI-FEKEKRQQLLTEIRTL--CEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGSLADI 179
+ ++ K +Q+L E+ L C +P +V+F+GAF+ G + + +EYMDGGSL I
Sbjct: 392 RLELDEAKFRQILMELEVLHKCNSPY---IVDFYGAFFI--EGAVYMCMEYMDGGSLDKI 446
Query: 180 LRKHRRI---PEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNL-KGEPKITDFG 235
+ I EP L+ + ++HGL L +++HRD+KP N+L + +G K+ DFG
Sbjct: 447 YDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFG 506
Query: 236 ISAGLESSVAMCATFVGTVTYMSPERIRN-----ESYSYPADIWSLGLALLECGTGEFPY 290
+S L +S+A T +G +YM+PERI++ +Y+ +DIWSLGL++LE G +PY
Sbjct: 507 VSGNLVASLAK--TNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPY 564
Query: 291 TAN--EGPVNLMLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFIT 348
+ + + I+D P P FS + F+ CLQK P+ RPT L HP++
Sbjct: 565 PPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLV 624
Query: 349 KYETVEVDLAGYV 361
KY +V ++ Y+
Sbjct: 625 KYRNQDVHMSEYI 637
>MPK6_HUMAN (P52564) Dual specificity mitogen-activated protein
kinase kinase 6 (EC 2.7.1.-) (MAP kinase kinase 6)
(MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 166 bits (419), Expect = 2e-40
Identities = 99/311 (31%), Positives = 161/311 (50%), Gaps = 11/311 (3%)
Query: 62 QKCSSSSRSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKK 121
Q S+ R +D + + + ++ +G GA VV++ H+P +I+A+K+
Sbjct: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR 83
Query: 122 INI-FEKEKRQQLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGS---LA 177
I +++++LL ++ V F+GA + G + I +E MD
Sbjct: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFYK 141
Query: 178 DILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGIS 237
++ K + IPE IL + ++ L +LH ++HRD+KP+N+L+N G+ K+ DFGIS
Sbjct: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS 201
Query: 238 AGLESSVAMCATFVGTVTYMSPERIRNE----SYSYPADIWSLGLALLECGTGEFPYTAN 293
L SVA G YM+PERI E YS +DIWSLG+ ++E FPY +
Sbjct: 202 GYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW 260
Query: 294 EGPVNLMLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETV 353
P + Q++++PSP FS EF F CL+K+ RPT +L+ HPF T +E+
Sbjct: 261 GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320
Query: 354 EVDLAGYVRSV 364
D+A +V+ +
Sbjct: 321 GTDVASFVKLI 331
>MPK6_MOUSE (P70236) Dual specificity mitogen-activated protein
kinase kinase 6 (EC 2.7.1.-) (MAP kinase kinase 6)
(MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 165 bits (418), Expect = 2e-40
Identities = 98/311 (31%), Positives = 161/311 (51%), Gaps = 11/311 (3%)
Query: 62 QKCSSSSRSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKK 121
Q S+ R +D + + + ++ +G GA VV++ H+P +I+A+K+
Sbjct: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKR 83
Query: 122 INI-FEKEKRQQLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGS---LA 177
I +++++LL ++ V F+GA + G + I +E MD
Sbjct: 84 IRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFYK 141
Query: 178 DILRKHRRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGIS 237
++ K + IPE IL + ++ L +LH ++HRD+KP+N+L+N G+ K+ DFGIS
Sbjct: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGIS 201
Query: 238 AGLESSVAMCATFVGTVTYMSPERIRNE----SYSYPADIWSLGLALLECGTGEFPYTAN 293
L SVA G YM+PERI E YS +DIWSLG+ ++E FPY +
Sbjct: 202 GYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW 260
Query: 294 EGPVNLMLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETV 353
P + Q++++PSP FS +F F CL+K+ RPT +L+ HPF T +E+
Sbjct: 261 GTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESK 320
Query: 354 EVDLAGYVRSV 364
D+A +V+ +
Sbjct: 321 AADVASFVKLI 331
>WIS1_SCHPO (P33886) Protein kinase wis1 (EC 2.7.1.-) (Protein
kinase sty2)
Length = 605
Score = 164 bits (415), Expect = 5e-40
Identities = 100/292 (34%), Positives = 159/292 (54%), Gaps = 15/292 (5%)
Query: 80 SEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINI-FEKEKRQQLLTEIR 138
S ++R E+ +G G VV +A+H P +ALK+I + E+ Q++ E+
Sbjct: 309 SGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELD 368
Query: 139 TLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGSLADILRKHRRIPEPILSSMFQKL 198
L +A +V+F+GAF+ G + I +EYMD GS+ D L E +L+ +
Sbjct: 369 ILHKAVSPY-IVDFYGAFFV--EGSVFICMEYMDAGSM-DKLYAGGIKDEGVLARTAYAV 424
Query: 199 LHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVAMCATFVGTVTYMS 258
+ GL L +++HRD+KP N+LVN G+ K+ DFG+S L +S++ T +G +YM+
Sbjct: 425 VQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISK--TNIGCQSYMA 482
Query: 259 PERIRNE-------SYSYPADIWSLGLALLECGTGEFPYTANE-GPVNLMLQILDDPSPS 310
PERIR +Y+ AD+WSLGL +LE G +PY + L + D P
Sbjct: 483 PERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPP 542
Query: 311 PSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVEVDLAGYVR 362
+FSPE F++ CL K+P +RP +L HP++ KY+ +VD+A + +
Sbjct: 543 SLPDSFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASWAK 594
>MPK3_MOUSE (O09110) Dual specificity mitogen-activated protein
kinase kinase 3 (EC 2.7.1.-) (MAP kinase kinase 3)
(MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 164 bits (414), Expect = 7e-40
Identities = 96/305 (31%), Positives = 162/305 (52%), Gaps = 13/305 (4%)
Query: 69 RSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKIN--IFE 126
R++D ++ + + ++ +G GA VV++ H I+A+K+I +
Sbjct: 42 RNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNT 101
Query: 127 KEKRQQLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGS---LADILRKH 183
+E+++ L+ + C+ V F+GA + G + I +E MD +L K+
Sbjct: 102 QEQKRLLMDLDINMRTVDCFY-TVTFYGALFR--EGDVWICMELMDTSLDKFYRKVLEKN 158
Query: 184 RRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESS 243
+IPE IL + ++ L +LH ++HRD+KP+N+L+N +G K+ DFGIS L S
Sbjct: 159 MKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS 218
Query: 244 VAMCATFVGTVTYMSPERIRNE----SYSYPADIWSLGLALLECGTGEFPYTANEGPVNL 299
VA G YM+PERI E Y+ +D+WSLG+ ++E FPY + P
Sbjct: 219 VAKTMD-AGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQ 277
Query: 300 MLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVEVDLAG 359
+ Q++++PSP FSPEF F CL+K+P R + +L+ HPF T ++T + D+A
Sbjct: 278 LKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 337
Query: 360 YVRSV 364
+V+ +
Sbjct: 338 FVKEI 342
>MPK3_HUMAN (P46734) Dual specificity mitogen-activated protein
kinase kinase 3 (EC 2.7.1.-) (MAP kinase kinase 3)
(MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 161 bits (408), Expect = 3e-39
Identities = 96/305 (31%), Positives = 161/305 (52%), Gaps = 13/305 (4%)
Query: 69 RSVDESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKIN--IFE 126
R++D ++ + + ++ +G GA VV++ H I+A+K+I +
Sbjct: 42 RNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNS 101
Query: 127 KEKRQQLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGS---LADILRKH 183
+E+++ L+ + C+ V F+GA + G + I +E MD +L K+
Sbjct: 102 QEQKRLLMDLDINMRTVDCFY-TVTFYGALFR--EGDVWICMELMDTSLDKFYRKVLDKN 158
Query: 184 RRIPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESS 243
IPE IL + ++ L +LH ++HRD+KP+N+L+N +G K+ DFGIS L S
Sbjct: 159 MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS 218
Query: 244 VAMCATFVGTVTYMSPERIRNE----SYSYPADIWSLGLALLECGTGEFPYTANEGPVNL 299
VA G YM+PERI E Y+ +D+WSLG+ ++E FPY + P
Sbjct: 219 VAKTMD-AGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQ 277
Query: 300 MLQILDDPSPSPSKQTFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVEVDLAG 359
+ Q++++PSP FSPEF F CL+K+P R + +L+ HPF T ++T + D+A
Sbjct: 278 LKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 337
Query: 360 YVRSV 364
+V+ +
Sbjct: 338 FVKEI 342
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.1.-)
Length = 363
Score = 160 bits (405), Expect = 8e-39
Identities = 109/308 (35%), Positives = 165/308 (53%), Gaps = 24/308 (7%)
Query: 73 ESHDSDHSEKTYRCGSREMRIFGAIGSGASSVVQRAIHIPKHRIIALKKINIFEKEKRQ- 131
E D DH + G + ++G G S V++ I A+K + Q
Sbjct: 63 EELDDDHLHELVTNGG--ILYMNSLGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQK 120
Query: 132 QLLTEIRT--LCEAPCYQGLVEFHGAFYTPDSGQISIALEYMDGGSLADILRKHR----R 185
QLL E++ C +P +V+++GA Y Q++IA+EY GSL I ++ R R
Sbjct: 121 QLLRELKINRSCTSPY---IVKYYGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGR 177
Query: 186 IPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLESSVA 245
E L + +L GLSYLH R ++HRDIKP+N+L+ KG+ K+ DFG+S L +S+A
Sbjct: 178 TGERPLGKIAFGVLSGLSYLHD-RKIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLA 236
Query: 246 MCATFVGTVTYMSPERIRNESYSYPADIWSLGLALLECGTGEFPYTANEG-----PVNLM 300
TF GT YM+PERI SY+ +DIWSLGL L+E FP+ EG P+ L+
Sbjct: 237 --GTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPP-EGSPPPMPIELL 293
Query: 301 LQILDDPSPSPSKQ---TFSPEFCSFIDACLQKDPDVRPTAEQLLFHPFITKYETVEVDL 357
I++ P P ++ +S F F+ CL KD RP +++L HP++ +E + VD+
Sbjct: 294 SYIINMPPPLLPQEPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHPWVKAFERIHVDM 353
Query: 358 AGYVRSVF 365
++R V+
Sbjct: 354 EEFLRQVW 361
>MPK2_XENLA (Q07192) Dual specificity mitogen-activated protein
kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2)
(MAPKK 2) (MAPK-ERK kinase 2) (Fragment)
Length = 446
Score = 160 bits (405), Expect = 8e-39
Identities = 120/387 (31%), Positives = 188/387 (48%), Gaps = 33/387 (8%)
Query: 8 RKKLAPLFDAEKGFGFSTSSTLDPCDDS-YTLSDGGTVNLLSRSYGVYNINELGLQKCSS 66
++K L A F + TL+P S + + + L SY ++ G + S+
Sbjct: 52 KRKALKLNFANPAFKSTAKFTLNPTIQSTHVMHKLDAIRKLETSYQKQDLRTSGAKALST 111
Query: 67 SSRSVDE------SHDSDHS-------EKTYRCGSREMRIFGAIGSGASSVVQRAIHIPK 113
+ ++ +H + S E+ + + +++ G IG GA V + H P
Sbjct: 112 NEQATKNRLERLRTHSIESSGKLKLSPEQHWDFTAEDLKDLGEIGRGAYGSVNKMSHTPS 171
Query: 114 HRIIALKKINIFEKEKRQ-QLLTEIRTLCEAPCYQGLVEFHGAFYTPDSGQISIALEYMD 172
+I+A+K+I EK Q QLL ++ + + +V+F+GA + G I +E M
Sbjct: 172 GQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFR--EGDCWICMELM- 228
Query: 173 GGSLADILRKHRR------IPEPILSSMFQKLLHGLSYLHGVRHLVHRDIKPANLLVNLK 226
+ D K+ IPE IL + + L++L ++HRDIKP+N+L++
Sbjct: 229 -ATSFDKFYKYVYSFLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDTN 287
Query: 227 GEPKITDFGISAGLESSVAMCATFVGTVTYMSPERI----RNESYSYPADIWSLGLALLE 282
G K+ DFGIS L S+A G YM+PERI + Y +D+WSLG+ L E
Sbjct: 288 GNIKLCDFGISGQLVDSIAKTRD-AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 346
Query: 283 CGTGEFPYTANEGPVNLMLQIL--DDPSPSPSKQT-FSPEFCSFIDACLQKDPDVRPTAE 339
TG FPY + + Q++ D P S S++ FSP F SF++ CL KD RP +
Sbjct: 347 LATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFTSFVNQCLTKDESKRPKYK 406
Query: 340 QLLFHPFITKYETVEVDLAGYVRSVFD 366
+LL HPFI YE VD+AGYV + +
Sbjct: 407 ELLKHPFILMYEERTVDVAGYVGKILE 433
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.320 0.138 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,590,992
Number of Sequences: 164201
Number of extensions: 2855895
Number of successful extensions: 10626
Number of sequences better than 10.0: 1671
Number of HSP's better than 10.0 without gapping: 1106
Number of HSP's successfully gapped in prelim test: 565
Number of HSP's that attempted gapping in prelim test: 6598
Number of HSP's gapped (non-prelim): 1971
length of query: 526
length of database: 59,974,054
effective HSP length: 115
effective length of query: 411
effective length of database: 41,090,939
effective search space: 16888375929
effective search space used: 16888375929
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Lotus: description of TM0263.11