BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0258b.5
         (360 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

RD19_ARATH (P43296) Cysteine proteinase RD19a precursor (EC 3.4....   544  e-154
A494_ARATH (P43295) Probable cysteine proteinase A494 precursor ...   534  e-151
CYSP_PEA (P25804) Cysteine proteinase 15A precursor (EC 3.4.22.-...   513  e-145
CYS1_MAIZE (Q10716) Cysteine proteinase 1 precursor (EC 3.4.22.-)     490  e-138
CYS1_DICDI (P04988) Cysteine proteinase 1 precursor (EC 3.4.22.-)     289  9e-78
CATL_SCHMA (Q26534) Cathepsin L precursor (EC 3.4.22.15) (SMCL1)      248  1e-65
CPR1_DROME (Q9VN93) Putative cysteine proteinase CG12163 precurs...   243  7e-64
CATF_MOUSE (Q9R013) Cathepsin F precursor (EC 3.4.22.41)              236  5e-62
CYSP_TRYCR (P25779) Cruzipain precursor (EC 3.4.22.51) (Major cy...   235  1e-61
CYSP_TRYBB (P14658) Cysteine proteinase precursor (EC 3.4.22.-)       235  1e-61
CATF_HUMAN (Q9UBX1) Cathepsin F precursor (EC 3.4.22.41) (CATSF)      234  3e-61
CATV_NPVAH (Q80LP4) Viral cathepsin (EC 3.4.22.50) (V-cath) (Cys...   229  6e-60
LCPA_LEIME (P25775) Cysteine proteinase A precursor (EC 3.4.22.-)     223  4e-58
CYS1_LEIPI (P35591) Cysteine proteinase 1 precursor (EC 3.4.22.-...   223  4e-58
CYS5_DICDI (P54640) Cysteine proteinase 5 precursor (EC 3.4.22.-)     217  3e-56
LCPB_LEIME (P36400) Cysteine proteinase B precursor (EC 3.4.22.-)     214  3e-55
CYS2_LEIPI (Q05094) Cysteine proteinase 2 precursor (EC 3.4.22.-...   213  6e-55
CATV_NPVMC (Q8QLK1) Viral cathepsin (EC 3.4.22.50) (V-cath) (Cys...   212  1e-54
CATL_SARPE (Q26636) Cathepsin L precursor (EC 3.4.22.15)              212  1e-54
CATL_RAT (P07154) Cathepsin L precursor (EC 3.4.22.15) (Major ex...   212  1e-54

>RD19_ARATH (P43296) Cysteine proteinase RD19a precursor (EC
           3.4.22.-) (RD19)
          Length = 368

 Score =  544 bits (1401), Expect = e-154
 Identities = 265/361 (73%), Positives = 303/361 (83%), Gaps = 7/361 (1%)

Query: 5   RILFLMFVF-FLFFSVVSSD--GGVDPLIRQVVDG---EGLGAEHHFLEFKRRFGKVYVS 58
           ++ F +FV  F   SV SSD   G D +IRQVV G   + L +E HF  FKR+FGKVY S
Sbjct: 5   KLYFSVFVLSFFIVSVSSSDVNDGDDLVIRQVVGGAEPQVLTSEDHFSLFKRKFGKVYAS 64

Query: 59  EEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHSVLGLR-GVGLPSDA 117
            EEH YRF+VFK+N+ RARRHQ LDPSA HGVT+FSDLT  EFR   LG+R G  LP DA
Sbjct: 65  NEEHDYRFSVFKANLRRARRHQKLDPSATHGVTQFSDLTRSEFRKKHLGVRSGFKLPKDA 124

Query: 118 DSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKLVSLSE 177
           + APIL T+NLP+DFDWR+HGAVTPVKNQGSCG+CWSFSATGALEGA+FL+TGKLVSLSE
Sbjct: 125 NKAPILPTENLPEDFDWRDHGAVTPVKNQGSCGSCWSFSATGALEGANFLATGKLVSLSE 184

Query: 178 QQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGTCKFDQ 237
           QQLVDCDHECDPEEA SCDSGC GGLMNSAFEY L  GG+M+EEDYPY+G  G TCK D+
Sbjct: 185 QQLVDCDHECDPEEADSCDSGCNGGLMNSAFEYTLKTGGLMKEEDYPYTGKDGKTCKLDK 244

Query: 238 TKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGVSCPYVCSKKLNHGV 297
           +KI ASV+NFSV+S DE+QIAANLVKNGPLAVAINA YMQTY+GGVSCPY+C+++LNHGV
Sbjct: 245 SKIVASVSNFSVISIDEEQIAANLVKNGPLAVAINAGYMQTYIGGVSCPYICTRRLNHGV 304

Query: 298 LLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRGRNVCGVDSMVSTVAALHT 357
           LLVGYG+  YAP R K+KPYWIIKNSWGE WGENG+YKIC+GRN+CGVDSMVSTVAA  +
Sbjct: 305 LLVGYGAAGYAPARFKEKPYWIIKNSWGETWGENGFYKICKGRNICGVDSMVSTVAATVS 364

Query: 358 T 358
           T
Sbjct: 365 T 365


>A494_ARATH (P43295) Probable cysteine proteinase A494 precursor (EC
           3.4.22.-)
          Length = 361

 Score =  534 bits (1376), Expect = e-151
 Identities = 257/354 (72%), Positives = 300/354 (84%), Gaps = 5/354 (1%)

Query: 5   RILFLMFVFFLFFSVVSSDGGVDPLIRQVVDG---EGLGAEHHFLEFKRRFGKVYVSEEE 61
           R+LF + + F+F SV S  G  D LIRQVVD    + L +E HF  FK++FGKVY S EE
Sbjct: 6   RVLFSVSLIFVFVSV-SVCGDEDVLIRQVVDETEPKVLSSEDHFTLFKKKFGKVYGSIEE 64

Query: 62  HGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHSVLGLRG-VGLPSDADSA 120
           H YRF+VFK+N+ RA RHQ +DPSA HGVT+FSDLT  EFR   LG++G   LP DA+ A
Sbjct: 65  HYYRFSVFKANLLRAMRHQKMDPSARHGVTQFSDLTRSEFRRKHLGVKGGFKLPKDANQA 124

Query: 121 PILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKLVSLSEQQL 180
           PIL T NLP++FDWR+ GAVTPVKNQGSCG+CWSFS TGALEGAHFL+TGKLVSLSEQQL
Sbjct: 125 PILPTQNLPEEFDWRDRGAVTPVKNQGSCGSCWSFSTTGALEGAHFLATGKLVSLSEQQL 184

Query: 181 VDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGTCKFDQTKI 240
           VDCDHECDPEE GSCDSGC GGLMNSAFEY L  GG+MRE+DYPY+GT GG+CK D++KI
Sbjct: 185 VDCDHECDPEEEGSCDSGCNGGLMNSAFEYTLKTGGLMREKDYPYTGTDGGSCKLDRSKI 244

Query: 241 AASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGVSCPYVCSKKLNHGVLLV 300
            ASV+NFSVVS +EDQIAANL+KNGPLAVAINA YMQTY+GGVSCPY+CS++LNHGVLLV
Sbjct: 245 VASVSNFSVVSINEDQIAANLIKNGPLAVAINAAYMQTYIGGVSCPYICSRRLNHGVLLV 304

Query: 301 GYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRGRNVCGVDSMVSTVAA 354
           GYGS  ++  R+K+KPYWIIKNSWGE+WGENG+YKIC+GRN+CGVDS+VSTVAA
Sbjct: 305 GYGSAGFSQARLKEKPYWIIKNSWGESWGENGFYKICKGRNICGVDSLVSTVAA 358


>CYSP_PEA (P25804) Cysteine proteinase 15A precursor (EC 3.4.22.-)
           (Turgor-responsive protein 15A)
          Length = 363

 Score =  513 bits (1321), Expect = e-145
 Identities = 248/359 (69%), Positives = 296/359 (82%), Gaps = 7/359 (1%)

Query: 2   VDHRILFLMFVFFLFFSVVSSDGGVDP-LIRQVVDGEG---LGAEHHFLEFKRRFGKVYV 57
           +D R LF +F+F    + V+ D   D  +IRQVVD E    L AEHHF  FK +F K Y 
Sbjct: 1   MDRRFLFALFLFAAVATAVTDDTNNDDFIIRQVVDNEEDHLLNAEHHFTSFKSKFSKSYA 60

Query: 58  SEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHSVLGLRG-VGLPSD 116
           ++EEH YRF VFKSN+ +A+ HQ  DP+A HG+T+FSDLT  EFR   LGL+  + LP+ 
Sbjct: 61  TKEEHDYRFGVFKSNLIKAKLHQNRDPTAEHGITKFSDLTASEFRRQFLGLKKRLRLPAH 120

Query: 117 ADSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKLVSLS 176
           A  APIL T NLP+DFDWRE GAVTPVK+QGSCG+CW+FS TGALEGAH+L+TGKLVSLS
Sbjct: 121 AQKAPILPTTNLPEDFDWREKGAVTPVKDQGSCGSCWAFSTTGALEGAHYLATGKLVSLS 180

Query: 177 EQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGTCKFD 236
           EQQLVDCDH CDPE+AGSCDSGC GGLMN+AFEY+L +GGV++E+DY Y+G   G+CKFD
Sbjct: 181 EQQLVDCDHVCDPEQAGSCDSGCNGGLMNNAFEYLLESGGVVQEKDYAYTG-RDGSCKFD 239

Query: 237 QTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGVSCPYVCSK-KLNH 295
           ++K+ ASV+NFSVV+ DEDQIAANLVKNGPLAVAINA +MQTY+ GVSCPYVC+K +L+H
Sbjct: 240 KSKVVASVSNFSVVTLDEDQIAANLVKNGPLAVAINAAWMQTYMSGVSCPYVCAKSRLDH 299

Query: 296 GVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRGRNVCGVDSMVSTVAA 354
           GVLLVG+G  +YAPIR+K+KPYWIIKNSWG+NWGE GYYKICRGRNVCGVDSMVSTVAA
Sbjct: 300 GVLLVGFGKGAYAPIRLKEKPYWIIKNSWGQNWGEQGYYKICRGRNVCGVDSMVSTVAA 358


>CYS1_MAIZE (Q10716) Cysteine proteinase 1 precursor (EC 3.4.22.-)
          Length = 371

 Score =  490 bits (1261), Expect = e-138
 Identities = 241/369 (65%), Positives = 281/369 (75%), Gaps = 16/369 (4%)

Query: 4   HRILFLMFVFFLFFSVVSSDGGVDPLIRQVVDGEG-----LGAEHHFLEFKRRFGKVYVS 58
           HR+L L+ +     +V ++    DPLIRQVV G       L AE HFL F +RFGK Y  
Sbjct: 3   HRVLLLLSLASAA-AVAAAVDAEDPLIRQVVPGGDDNDLELNAESHFLSFVQRFGKSYKD 61

Query: 59  EEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHSVLGLRGVG------ 112
            +EH YR +VFK N+ RARRHQLLDPSA HGVT+FSDLTP EFR + LGLR         
Sbjct: 62  ADEHAYRLSVFKDNLRRARRHQLLDPSAEHGVTKFSDLTPAEFRRTYLGLRKSRRALLRE 121

Query: 113 LPSDADSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKL 172
           L   A  AP+L TD LP DFDWR+HGAV PVKNQGSCG+CWSFSA+GALEGAH+L+TGKL
Sbjct: 122 LGESAHEAPVLPTDGLPDDFDWRDHGAVGPVKNQGSCGSCWSFSASGALEGAHYLATGKL 181

Query: 173 VSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGT 232
             LSEQQ VDCDHECD  E  SCDSGC GGLM +AF Y+   GG+  E+DYPY+G+  G 
Sbjct: 182 EVLSEQQFVDCDHECDSSEPDSCDSGCNGGLMTTAFSYLQKAGGLESEKDYPYTGS-DGK 240

Query: 233 CKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGVSCPYVCSKK 292
           CKFD++KI ASV NFSVVS DE QI+ANL+K+GPLA+ INA YMQTY+GGVSCPY+C + 
Sbjct: 241 CKFDKSKIVASVQNFSVVSVDEAQISANLIKHGPLAIGINAAYMQTYIGGVSCPYICGRH 300

Query: 293 LNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRG---RNVCGVDSMV 349
           L+HGVLLVGYG+  +APIR+K KPYWIIKNSWGENWGENGYYKICRG   RN CGVDSMV
Sbjct: 301 LDHGVLLVGYGASGFAPIRLKDKPYWIIKNSWGENWGENGYYKICRGSNVRNKCGVDSMV 360

Query: 350 STVAALHTT 358
           STV+A+H +
Sbjct: 361 STVSAVHAS 369


>CYS1_DICDI (P04988) Cysteine proteinase 1 precursor (EC 3.4.22.-)
          Length = 343

 Score =  289 bits (739), Expect = 9e-78
 Identities = 154/353 (43%), Positives = 209/353 (58%), Gaps = 23/353 (6%)

Query: 7   LFLMFVFFLFFSVVSSDGGVDPLIRQVVDGEGLGAEHHFLEFKRRFGKVYVSEEEHGYRF 66
           + L+FV  +F   VSS G + P             +  FLEF+ +F K Y S EE+  RF
Sbjct: 3   VILLFVLAVFTVFVSSRG-IPP-----------EEQSQFLEFQDKFNKKY-SHEEYLERF 49

Query: 67  NVFKSNMHRARRHQLL----DPSAVHGVTRFSDLTPMEFRHSVLGLRGVGLPSDADSAPI 122
            +FKSN+ +     L+          GV +F+DL+  EF++  L  +      D   A  
Sbjct: 50  EIFKSNLGKIEELNLIAINHKADTKFGVNKFADLSSDEFKNYYLNNKEAIFTDDLPVADY 109

Query: 123 LRTD---NLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKLVSLSEQQ 179
           L  +   ++P  FDWR  GAVTPVKNQG CG+CWSFS TG +EG HF+S  KLVSLSEQ 
Sbjct: 110 LDDEFINSIPTAFDWRTRGAVTPVKNQGQCGSCWSFSTTGNVEGQHFISQNKLVSLSEQN 169

Query: 180 LVDCDHEC-DPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGTCKFDQT 238
           LVDCDHEC + E   +CD GC GGL  +A+ YI+ NGG+  E  YPY+   G  C F+  
Sbjct: 170 LVDCDHECMEYEGEEACDEGCNGGLQPNAYNYIIKNGGIQTESSYPYTAETGTQCNFNSA 229

Query: 239 KIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGVSCPYVCSKKLNHGVL 298
            I A ++NF+++ ++E  +A  +V  GPLA+A +AV  Q Y+GGV         L+HG+L
Sbjct: 230 NIGAKISNFTMIPKNETVMAGYIVSTGPLAIAADAVEWQFYIGGVFDIPCNPNSLDHGIL 289

Query: 299 LVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRGRNVCGVDSMVST 351
           +VGY +++   I  K  PYWI+KNSWG +WGE GY  + RG+N CGV + VST
Sbjct: 290 IVGYSAKN--TIFRKNMPYWIVKNSWGADWGEQGYIYLRRGKNTCGVSNFVST 340


>CATL_SCHMA (Q26534) Cathepsin L precursor (EC 3.4.22.15) (SMCL1)
          Length = 319

 Score =  248 bits (634), Expect = 1e-65
 Identities = 136/317 (42%), Positives = 198/317 (61%), Gaps = 25/317 (7%)

Query: 42  EHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQL-LDPSAVHGVTRFSDLTPME 100
           +  +++FK ++ K Y  E E   RFN+FKSN+ +A+ +Q+ +  SA++GVT +SDLT  E
Sbjct: 17  DEKYVQFKLKYRKQY-HETEDEIRFNIFKSNILKAQLYQVFVRGSAIYGVTPYSDLTTDE 75

Query: 101 FRHSVLGLRGVGLPSDADSAPIL---RTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSA 157
           F  + L    V +PS   + P       +N+PK+FDWRE GAVT VKNQG CG+CW+FS 
Sbjct: 76  FARTHLTASWV-VPSSRSNTPTSLGKEVNNIPKNFDWREKGAVTEVKNQGMCGSCWAFST 134

Query: 158 TGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGV 217
           TG +E   F  TGKL+SLSEQQLVDCD           D GC GGL ++A+E I+  GG+
Sbjct: 135 TGNVESQWFRKTGKLLSLSEQQLVDCD---------GLDDGCNGGLPSNAYESIIKMGGL 185

Query: 218 MREEDYPYSGTAGGTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQ 277
           M E++YPY       C      +A  + +   +++DE ++AA L  N  ++V +NA+ +Q
Sbjct: 186 MLEDNYPYD-AKNEKCHLKTDGVAVYINSSVNLTQDETELAAWLYHNSTISVGMNALLLQ 244

Query: 278 TYVGGVSCPY--VCSK-KLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYY 334
            Y  G+S P+   CSK  L+H VLLVGYG      +  K +P+WI+KNSWG  WGENGY+
Sbjct: 245 FYQHGISHPWWIFCSKYLLDHAVLLVGYG------VSEKNEPFWIVKNSWGVEWGENGYF 298

Query: 335 KICRGRNVCGVDSMVST 351
           ++ RG   CG++++ ++
Sbjct: 299 RMYRGDGSCGINTVATS 315


>CPR1_DROME (Q9VN93) Putative cysteine proteinase CG12163 precursor
           (EC 3.4.22.-)
          Length = 614

 Score =  243 bits (619), Expect = 7e-64
 Identities = 134/317 (42%), Positives = 188/317 (59%), Gaps = 18/317 (5%)

Query: 42  EHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDP-SAVHGVTRFSDLTPME 100
           +H F +F+ RFG+ YVS  E   R  +F+ N+         +  SA +G+T F+D+T  E
Sbjct: 305 DHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSE 364

Query: 101 FRHSVLGLRGVGLPSDADSAPILRT--DNLPKDFDWREHGAVTPVKNQGSCGACWSFSAT 158
           ++      +     +   SA ++      LPK+FDWR+  AVT VKNQGSCG+CW+FS T
Sbjct: 365 YKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVT 424

Query: 159 GALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVM 218
           G +EG + + TG+L   SEQ+L+DCD         + DS C GGLM++A++ I + GG+ 
Sbjct: 425 GNIEGLYAVKTGELKEFSEQELLDCD---------TTDSACNGGLMDNAYKAIKDIGGLE 475

Query: 219 REEDYPYSGTAGGTCKFDQTKIAASVANF-SVVSRDEDQIAANLVKNGPLAVAINAVYMQ 277
            E +YPY       C F++T     VA F  +   +E  +   L+ NGP+++ INA  MQ
Sbjct: 476 YEAEYPYKAKK-NQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQ 534

Query: 278 TYVGGVSCPY--VCSKK-LNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYY 334
            Y GGVS P+  +CSKK L+HGVL+VGYG   Y P   K  PYWI+KNSWG  WGE GYY
Sbjct: 535 FYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDY-PNFHKTLPYWIVKNSWGPRWGEQGYY 593

Query: 335 KICRGRNVCGVDSMVST 351
           ++ RG N CGV  M ++
Sbjct: 594 RVYRGDNTCGVSEMATS 610


>CATF_MOUSE (Q9R013) Cathepsin F precursor (EC 3.4.22.41)
          Length = 462

 Score =  236 bits (603), Expect = 5e-62
 Identities = 136/312 (43%), Positives = 188/312 (59%), Gaps = 23/312 (7%)

Query: 45  FLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDP-SAVHGVTRFSDLTPMEFRH 103
           F +F   + + Y S EE  +R  VF  NM RA++ Q LD  +A +G+T+FSDLT  EF H
Sbjct: 165 FKDFMTTYNRTYESREEAQWRLTVFARNMIRAQKIQALDRGTAQYGITKFSDLTEEEF-H 223

Query: 104 SVLGLRGVGLPSDADSAPILRTDNL-PKDFDWREHGAVTPVKNQGSCGACWSFSATGALE 162
           ++     +   S    +P    ++L P ++DWR+ GAVT VKNQG CG+CW+FS TG +E
Sbjct: 224 TIYLNPLLQKESGRKMSPAKSINDLAPPEWDWRKKGAVTEVKNQGMCGSCWAFSVTGNVE 283

Query: 163 GAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREED 222
           G  FL+ G L+SLSEQ+L+DCD           D  C GGL ++A+  I N GG+  E+D
Sbjct: 284 GQWFLNRGTLLSLSEQELLDCD---------KVDKACLGGLPSNAYAAIKNLGGLETEDD 334

Query: 223 YPYSGTAGGTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGG 282
           Y Y G    TC F        + +   +SR+E++IAA L + GP++VAINA  MQ Y  G
Sbjct: 335 YGYQGHV-QTCNFSAQMAKVYINDSVELSRNENKIAAWLAQKGPISVAINAFGMQFYRHG 393

Query: 283 VSCPY--VCSK-KLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRG 339
           ++ P+  +CS   ++H VLLVGYG+ S         PYW IKNSWG +WGE GYY + RG
Sbjct: 394 IAHPFRPLCSPWFIDHAVLLVGYGNRS-------NIPYWAIKNSWGSDWGEEGYYYLYRG 446

Query: 340 RNVCGVDSMVST 351
              CGV++M S+
Sbjct: 447 SGACGVNTMASS 458


>CYSP_TRYCR (P25779) Cruzipain precursor (EC 3.4.22.51) (Major
           cysteine proteinase) (Cruzaine)
          Length = 467

 Score =  235 bits (600), Expect = 1e-61
 Identities = 137/313 (43%), Positives = 174/313 (54%), Gaps = 23/313 (7%)

Query: 45  FLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHS 104
           F EFK++ G+VY S  E  +R +VF+ N+  AR H   +P A  GVT FSDLT  EFR  
Sbjct: 38  FAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSR 97

Query: 105 VL-GLRGVGLPSDADSAPI-LRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALE 162
              G        +    P+ +     P   DWR  GAVT VK+QG CG+CW+FSA G +E
Sbjct: 98  YHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVE 157

Query: 163 GAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYIL--NNGGVMRE 220
              FL+   L +LSEQ LV CD           DSGC GGLMN+AFE+I+  NNG V  E
Sbjct: 158 CQWFLAGHPLTNLSEQMLVSCD---------KTDSGCSGGLMNNAFEWIVQENNGAVYTE 208

Query: 221 EDYPYSGTAG--GTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQT 278
           + YPY+   G    C      + A++     + +DE QIAA L  NGP+AVA++A    T
Sbjct: 209 DSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMT 268

Query: 279 YVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICR 338
           Y GGV    V S++L+HGVLLVGY   +         PYWIIKNSW   WGE GY +I +
Sbjct: 269 YTGGVMTSCV-SEQLDHGVLLVGYNDSAAV-------PYWIIKNSWTTQWGEEGYIRIAK 320

Query: 339 GRNVCGVDSMVST 351
           G N C V    S+
Sbjct: 321 GSNQCLVKEEASS 333


>CYSP_TRYBB (P14658) Cysteine proteinase precursor (EC 3.4.22.-)
          Length = 450

 Score =  235 bits (600), Expect = 1e-61
 Identities = 139/322 (43%), Positives = 182/322 (56%), Gaps = 35/322 (10%)

Query: 42  EHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEF 101
           E  F  FK+++GKVY   +E  +RF  F+ NM +A+     +P A  GVT FSD+T  EF
Sbjct: 38  EMRFAAFKKKYGKVYKDAKEEAFRFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEF 97

Query: 102 RHSVLGLRGVGLPSDADSAPILR------TDNLPKDFDWREHGAVTPVKNQGSCGACWSF 155
           R         G    A +   LR      T   P   DWRE GAVTPVK QG CG+CW+F
Sbjct: 98  RARYRN----GASYFAAAQKRLRKTVNVTTGRAPAAVDWREKGAVTPVKVQGQCGSCWAF 153

Query: 156 SATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNN- 214
           S  G +EG   ++   LVSLSEQ LV CD         + DSGC GGLM++AF +I+N+ 
Sbjct: 154 STIGNIEGQWQVAGNPLVSLSEQMLVSCD---------TIDSGCNGGLMDNAFNWIVNSN 204

Query: 215 -GGVMREEDYPYSGTAG--GTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAI 271
            G V  E  YPY    G    C+ +  +I A++ +   + +DED IAA L +NGPLA+A+
Sbjct: 205 GGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDHVDLPQDEDAIAAYLAENGPLAIAV 264

Query: 272 NAVYMQTYVGGV--SCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWG 329
           +A     Y GG+  SC    SK+L+HGVLLVGY   S         PYWIIKNSW   WG
Sbjct: 265 DAESFMDYNGGILTSC---TSKQLDHGVLLVGYNDNS-------NPPYWIIKNSWSNMWG 314

Query: 330 ENGYYKICRGRNVCGVDSMVST 351
           E+GY +I +G N C ++  VS+
Sbjct: 315 EDGYIRIEKGTNQCLMNQAVSS 336


>CATF_HUMAN (Q9UBX1) Cathepsin F precursor (EC 3.4.22.41) (CATSF)
          Length = 484

 Score =  234 bits (597), Expect = 3e-61
 Identities = 136/311 (43%), Positives = 183/311 (58%), Gaps = 21/311 (6%)

Query: 45  FLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDP-SAVHGVTRFSDLTPMEFRH 103
           F  F   + + Y S+EE  +R +VF +NM RA++ Q LD  +A +GVT+FSDLT  EFR 
Sbjct: 187 FKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRT 246

Query: 104 SVLGLRGVGLPSDADSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEG 163
             L       P +         D  P ++DWR  GAVT VK+QG CG+CW+FS TG +EG
Sbjct: 247 IYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEG 306

Query: 164 AHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDY 223
             FL+ G L+SLSEQ+L+DCD           D  C GGL ++A+  I N GG+  E+DY
Sbjct: 307 QWFLNQGTLLSLSEQELLDCD---------KMDKACMGGLPSNAYSAIKNLGGLETEDDY 357

Query: 224 PYSGTAGGTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVYMQTYVGGV 283
            Y G    +C F   K    + +   +S++E ++AA L K GP++VAINA  MQ Y  G+
Sbjct: 358 SYQGHM-QSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGI 416

Query: 284 SCPY--VCSKKL-NHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICRGR 340
           S P   +CS  L +H VLLVGYG+ S         P+W IKNSWG +WGE GYY + RG 
Sbjct: 417 SRPLRPLCSPWLIDHAVLLVGYGNRS-------DVPFWAIKNSWGTDWGEKGYYYLHRGS 469

Query: 341 NVCGVDSMVST 351
             CGV++M S+
Sbjct: 470 GACGVNTMASS 480


>CATV_NPVAH (Q80LP4) Viral cathepsin (EC 3.4.22.50) (V-cath)
           (Cysteine proteinase) (CP)
          Length = 337

 Score =  229 bits (585), Expect = 6e-60
 Identities = 125/331 (37%), Positives = 187/331 (55%), Gaps = 36/331 (10%)

Query: 41  AEHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPME 100
           A+H+F  F   + K Y   +   YRF +FK N+        L+ SA++ + +FSDL+  E
Sbjct: 28  AQHYFETFIINYNKQYPDTKTKNYRFKIFKQNLEDINEKNKLNDSAIYNINKFSDLSKNE 87

Query: 101 FRHSVLGLRGVGLPSDA-------------DSAPILRTDNLPKDFDWREHGAVTPVKNQG 147
                 GL     PS+              D+ P +  D LP++FDWR +  +T VK+QG
Sbjct: 88  LLTKYTGLTSKK-PSNMVRSTSNFCNVIHLDAPPDVH-DELPQNFDWRVNNKMTSVKDQG 145

Query: 148 SCGACWSFSATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSA 207
           +CG+CW+ +A G LE  + +    L++LSEQQL+DCD         S +  C GGLM++A
Sbjct: 146 ACGSCWAHAAVGTLETLYAIKHNYLINLSEQQLIDCD---------SANMACDGGLMHTA 196

Query: 208 FEYILNNGGVMREEDYPYSGTAGGTCKFDQTKIAASVANFS-VVSRDEDQIAANLVKNGP 266
           FE ++N GG+M E DYPY GT  G CK D  K A SV++    + ++E+ +   L+  GP
Sbjct: 197 FEQLMNAGGLMEEIDYPYQGTK-GVCKIDNKKFALSVSSCKRYIFQNEENLKKELITMGP 255

Query: 267 LAVAINAVYMQTYVGGVSCPYVCSK-KLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWG 325
           +A+AI+A  + TY  G+   + C    LNH VLLVGYG+E           YW +KNSWG
Sbjct: 256 IAMAIDAASISTYSKGII--HFCENLGLNHAVLLVGYGTEGGV-------SYWTLKNSWG 306

Query: 326 ENWGENGYYKICRGRNVCGVDSMVSTVAALH 356
            +WGE+GY+++ R  N CG+++ ++  A +H
Sbjct: 307 SDWGEDGYFRVKRNINACGLNNQLAASATIH 337


>LCPA_LEIME (P25775) Cysteine proteinase A precursor (EC 3.4.22.-)
          Length = 354

 Score =  223 bits (569), Expect = 4e-58
 Identities = 133/328 (40%), Positives = 181/328 (54%), Gaps = 30/328 (9%)

Query: 41  AEHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVT-RFSDLTPM 99
           A  H+  FK+R GK +  + E G+RFN FK NM  A      +P A + V+ +F+DLTP 
Sbjct: 38  ASAHYGSFKKRHGKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNPHAHYDVSGKFADLTPQ 97

Query: 100 EFRHSVLGLRGVGLPSDADSAPILRTDNLPK---DFDWREHGAVTPVKNQGSCGACWSFS 156
           EF    L               +   D+ P      DWR+ GAVTPVKNQG CG+CW+FS
Sbjct: 98  EFAKLYLNPDYYARHLKNHKEDVHVDDSAPSGVMSVDWRDKGAVTPVKNQGLCGSCWAFS 157

Query: 157 ATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYIL--NN 214
           A G +EG    S   LVSLSEQ LV CD         + D GC GGLM+ A  +I+  +N
Sbjct: 158 AIGNIEGQWAASGHSLVSLSEQMLVSCD---------NIDEGCNGGLMDQAMNWIMQSHN 208

Query: 215 GGVMREEDYPYSGTAGGT---CKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAI 271
           G V  E  YPY+ + GGT   C  D+ ++ A +  F  +  DE++IA  + K GP+AVA+
Sbjct: 209 GSVFTEASYPYT-SGGGTRPPC-HDEGEVGAKITGFLSLPHDEERIAEWVEKRGPVAVAV 266

Query: 272 NAVYMQTYVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGEN 331
           +A   Q Y GGV      +  LNHGVL+VG+   +       + PYWI+KNSWG +WGE 
Sbjct: 267 DATTWQLYFGGV-VSLCLAWSLNHGVLIVGFNKNA-------KPPYWIVKNSWGSSWGEK 318

Query: 332 GYYKICRGRNVCGVDS--MVSTVAALHT 357
           GY ++  G N C + +  + +TV + HT
Sbjct: 319 GYIRLAMGSNQCMLKNYPVSATVESPHT 346


>CYS1_LEIPI (P35591) Cysteine proteinase 1 precursor (EC 3.4.22.-)
           (Amastigote cysteine proteinase A-1)
          Length = 354

 Score =  223 bits (569), Expect = 4e-58
 Identities = 133/328 (40%), Positives = 181/328 (54%), Gaps = 30/328 (9%)

Query: 41  AEHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVT-RFSDLTPM 99
           A  H+  FK+R GK +  + E G+RFN FK NM  A      +P A + V+ +F+DLTP 
Sbjct: 38  ASAHYGSFKKRHGKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNPHAHYDVSGKFADLTPQ 97

Query: 100 EFRHSVLGLRGVGLPSDADSAPILRTDNLPK---DFDWREHGAVTPVKNQGSCGACWSFS 156
           EF    L               +   D+ P      DWR+ GAVTPVKNQG CG+CW+FS
Sbjct: 98  EFAKLYLNPDYYARHLKDHKEDVHVDDSAPSGVMSVDWRDKGAVTPVKNQGLCGSCWAFS 157

Query: 157 ATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYIL--NN 214
           A G +EG    S   LVSLSEQ LV CD         + D GC GGLM+ A  +I+  +N
Sbjct: 158 AIGNIEGQWAASGHSLVSLSEQMLVSCD---------NIDEGCNGGLMDQAMNWIMQSHN 208

Query: 215 GGVMREEDYPYSGTAGGT---CKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAI 271
           G V  E  YPY+ + GGT   C  D+ ++ A +  F  +  DE++IA  + K GP+AVA+
Sbjct: 209 GSVFTEASYPYT-SGGGTRPPC-HDEGEVGAKITGFLSLPHDEERIAEWVEKRGPVAVAV 266

Query: 272 NAVYMQTYVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGEN 331
           +A   Q Y GGV      +  LNHGVL+VG+   +       + PYWI+KNSWG +WGE 
Sbjct: 267 DATTWQLYFGGV-VSLCLAWSLNHGVLIVGFNKNA-------KPPYWIVKNSWGSSWGEK 318

Query: 332 GYYKICRGRNVCGVDS--MVSTVAALHT 357
           GY ++  G N C + +  + +TV + HT
Sbjct: 319 GYIRLAMGSNQCMLKNYPVSATVESPHT 346


>CYS5_DICDI (P54640) Cysteine proteinase 5 precursor (EC 3.4.22.-)
          Length = 344

 Score =  217 bits (553), Expect = 3e-56
 Identities = 125/313 (39%), Positives = 168/313 (52%), Gaps = 27/313 (8%)

Query: 54  KVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEFRHSVLGLRGVGL 113
           K Y SEE  G R+N+F +NM   ++        V G+  F+D+T  E+R++ LG +    
Sbjct: 39  KSYTSEE-FGARYNIFTANMDYVQQWNSKGSETVLGLNNFADITNEEYRNTYLGTKFDAS 97

Query: 114 PSDADSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGALEGAHFLSTGKLV 173
                    + T++     DWR  GAVTPVKNQG CG CWSFS TG+ EGAHF S G+LV
Sbjct: 98  SLIGTQEEKVHTNSSAASKDWRSEGAVTPVKNQGQCGGCWSFSTTGSTEGAHFQSKGELV 157

Query: 174 SLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREEDYPYSGTAGGTC 233
           SLSEQ L+DC  E         +SGC GGLM  AFEYI+NN G+  E  YPY     G C
Sbjct: 158 SLSEQNLIDCSTE---------NSGCDGGLMTYAFEYIINNNGIDTESSYPYK-AENGKC 207

Query: 234 KFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVY--MQTYVGGVSC-PYVCS 290
           ++      A+++++  V+   +    + V   P++VAI+A +   Q Y  G+   P   S
Sbjct: 208 EYKSENSGATLSSYKTVTAGSESSLESAVNVNPVSVAIDASHQSFQLYTSGIYYEPECSS 267

Query: 291 KKLNHGVLLVGYGSESYAP------------IRMKQKPYWIIKNSWGENWGENGYYKICR 338
           + L+HGVL VGYGS S +                    YWI+KNSWG +WG  GY  + R
Sbjct: 268 ENLDHGVLAVGYGSGSGSSSGQSSGQSSGNLSASSSNEYWIVKNSWGTSWGIEGYILMSR 327

Query: 339 GR-NVCGVDSMVS 350
            R N CG+ S  S
Sbjct: 328 NRDNNCGIASSAS 340


>LCPB_LEIME (P36400) Cysteine proteinase B precursor (EC 3.4.22.-)
          Length = 443

 Score =  214 bits (545), Expect = 3e-55
 Identities = 124/316 (39%), Positives = 169/316 (53%), Gaps = 27/316 (8%)

Query: 38  GLGAEHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLT 97
           G  A   F EFKR +G+ Y +  E   R   F+ N+   R HQ  +P A  G+T+F DL+
Sbjct: 31  GTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNPHAQFGITKFFDLS 90

Query: 98  PMEFRHSVLGLRGVGLPSDADSAPILRTDN-----LPKDFDWREHGAVTPVKNQGSCGAC 152
             EF    L        +   +A   R        +P   DWRE GAVTPVK+QG+CG+C
Sbjct: 91  EAEFAARYLNGAAYFAAAKRHAAQHYRKARADLSAVPDAVDWREKGAVTPVKDQGACGSC 150

Query: 153 WSFSATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYIL 212
           W+FSA G +EG  +L+  +LVSLSEQQLV CD           + GC GGLM  AF+++L
Sbjct: 151 WAFSAVGNIEGQWYLAGHELVSLSEQQLVSCD---------DMNDGCDGGLMLQAFDWLL 201

Query: 213 --NNGGVMREEDYPY---SGTAGGTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPL 267
              NG +  E+ YPY   +G         +  + A +    ++   E  +AA L KNGP+
Sbjct: 202 QNTNGHLHTEDSYPYVSGNGYVPECSNSSELVVGAQIDGHVLIGSSEKAMAAWLAKNGPI 261

Query: 268 AVAINAVYMQTYVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGEN 327
           A+A++A    +Y  GV    +  K+LNHGVLLVGY           + PYW+IKNSWG +
Sbjct: 262 AIALDASSFMSYKSGVLTACI-GKQLNHGVLLVGYDMTG-------EVPYWVIKNSWGGD 313

Query: 328 WGENGYYKICRGRNVC 343
           WGE GY ++  G N C
Sbjct: 314 WGEQGYVRVVMGVNAC 329


>CYS2_LEIPI (Q05094) Cysteine proteinase 2 precursor (EC 3.4.22.-)
           (Amastigote cysteine proteinase A-2)
          Length = 444

 Score =  213 bits (542), Expect = 6e-55
 Identities = 124/317 (39%), Positives = 170/317 (53%), Gaps = 28/317 (8%)

Query: 38  GLGAEHHFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLT 97
           G  A   F EFKR +G+ Y +  E   R   F+ N+   R HQ  +P A  G+T+F DL+
Sbjct: 31  GTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNPHAQFGITKFFDLS 90

Query: 98  PMEFRHSVLGLRGVGLPSDADSAPILRTDN-----LPKDFDWREHGAVTPVKNQGSCGAC 152
             EF    L        +   +A   R        +P   DWRE GAVTPVK+QG+CG+C
Sbjct: 91  EAEFAARYLNGAAYFAAAKRHAAQHYRKARADLSAVPDAVDWREKGAVTPVKDQGACGSC 150

Query: 153 WSFSATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYIL 212
           W+FSA G +EG  +L+  +LVSLSEQQLV CD           + GC GGLM  AF+++L
Sbjct: 151 WAFSAVGNIEGQWYLAGHELVSLSEQQLVSCD---------DMNDGCDGGLMLQAFDWLL 201

Query: 213 --NNGGVMREEDYPYSGTAG----GTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGP 266
              NG +  E+ YPY    G     +   ++  + A +    ++   E  +AA L KNGP
Sbjct: 202 QNTNGHLHTEDSYPYVSGNGYVPECSNSSEELVVGAQIDGHVLIGSSEKAMAAWLAKNGP 261

Query: 267 LAVAINAVYMQTYVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGE 326
           +A+A++A    +Y  GV    +  K+LNHGVLLVGY           + PYW+IKNSWG 
Sbjct: 262 IAIALDASSFMSYKSGVLTACI-GKQLNHGVLLVGYDMTG-------EVPYWVIKNSWGG 313

Query: 327 NWGENGYYKICRGRNVC 343
           +WGE GY ++  G N C
Sbjct: 314 DWGEQGYVRVVMGVNAC 330


>CATV_NPVMC (Q8QLK1) Viral cathepsin (EC 3.4.22.50) (V-cath)
           (Cysteine proteinase) (CP)
          Length = 337

 Score =  212 bits (539), Expect = 1e-54
 Identities = 124/320 (38%), Positives = 180/320 (55%), Gaps = 30/320 (9%)

Query: 44  HFLEFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTRFSDLTPMEF-- 101
           +F +F  ++ K Y SE+E  YR+N+F+ N+         + SAV+ + RF+D+T  E   
Sbjct: 39  YFEKFISQYNKQYSSEDEKKYRYNIFRHNIESINAKNSRNDSAVYKINRFADMTKNEVVN 98

Query: 102 RHSVLGLRGVGLPSDADSAPILRTDN-----LPKDFDWREHGAVTPVKNQGSCGACWSFS 156
           RH+ L    +G    A+    +  D       P +FDWR +  VT VK+QG CGACW+F+
Sbjct: 99  RHTGLASGDIG----ANFCETIVVDGPGQRQRPANFDWRNYNKVTSVKDQGMCGACWAFA 154

Query: 157 ATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGG 216
             GALE  + +   +L+ L+EQQLVDCD           D GC GGL+++A+E I++ GG
Sbjct: 155 GLGALESQYAIKYDRLIDLAEQQLVDCDF---------VDMGCDGGLIHTAYEQIMHIGG 205

Query: 217 VMREEDYPYSGTAGGTCKFDQTKIAASVAN-FSVVSRDEDQIAANLVKNGPLAVAINAVY 275
           V +E DYPY       C     K A  V N +  V   E+++   L   GP+A+A++AV 
Sbjct: 206 VEQEYDYPYKAVR-LPCAVKPHKFAVGVRNCYRYVLLSEERLEDLLRHVGPIAIAVDAVD 264

Query: 276 MQTYVGGVSCPYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYK 335
           +  Y GGV   +  +  LNH VLLVGYG E+         PYW IKNSWG ++GENGY +
Sbjct: 265 LTDYYGGV-ISFCENNGLNHAVLLVGYGIEN-------NVPYWTIKNSWGSDYGENGYVR 316

Query: 336 ICRGRNVCGVDSMVSTVAAL 355
           I RG N CG+ + +++ A +
Sbjct: 317 IRRGVNSCGMINELASSAQI 336


>CATL_SARPE (Q26636) Cathepsin L precursor (EC 3.4.22.15)
          Length = 339

 Score =  212 bits (539), Expect = 1e-54
 Identities = 125/316 (39%), Positives = 177/316 (55%), Gaps = 34/316 (10%)

Query: 48  FKRRFGKVYVSEEEHGYRFNVFKSNMHRARRH-QLLDPSAVH---GVTRFSDLTPMEFRH 103
           +K +  K Y +E E  +R  +F  N H+  +H QL     V    G+ +++D+   EF+ 
Sbjct: 31  YKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADMLHHEFKE 90

Query: 104 SVLGLRGV---------GLPSDADSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWS 154
           ++ G             GL       P   T  +PK  DWREHGAVT VK+QG CG+CW+
Sbjct: 91  TMNGYNHTLRQLMRERTGLVGATYIPPAHVT--VPKSVDWREHGAVTGVKDQGHCGSCWA 148

Query: 155 FSATGALEGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNN 214
           FS+TGALEG HF   G LVSLSEQ LVDC  +         ++GC GGLM++AF YI +N
Sbjct: 149 FSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYG-------NNGCNGGLMDNAFRYIKDN 201

Query: 215 GGVMREEDYPYSGTAGGTCKFDQTKIAASVANF-SVVSRDEDQIAANLVKNGPLAVAINA 273
           GG+  E+ YPY G    +C F++  I A+   F  +   DE+++   +   GP++VAI+A
Sbjct: 202 GGIDTEKSYPYEG-IDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDA 260

Query: 274 VY--MQTYVGGVSCPYVCSKK-LNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGE 330
            +   Q Y  GV     C ++ L+HGVL+VGYG++           YW++KNSWG  WGE
Sbjct: 261 SHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDE------SGMDYWLVKNSWGTTWGE 314

Query: 331 NGYYKICRGR-NVCGV 345
            GY K+ R + N CG+
Sbjct: 315 QGYIKMARNQNNQCGI 330


>CATL_RAT (P07154) Cathepsin L precursor (EC 3.4.22.15) (Major
           excreted protein) (MEP) (Cyclic protein-2) (CP-2)
          Length = 334

 Score =  212 bits (539), Expect = 1e-54
 Identities = 127/313 (40%), Positives = 174/313 (55%), Gaps = 23/313 (7%)

Query: 47  EFKRRFGKVYVSEEEHGYRFNVFKSNMHRARRHQLLDPSAVHGVTR----FSDLTPMEFR 102
           ++K    ++Y + EE  +R  V++ NM   + H     +  HG T     F D+T  EFR
Sbjct: 31  QWKSTHRRLYGTNEEE-WRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFR 89

Query: 103 HSVLGLRGVGLPSDA-DSAPILRTDNLPKDFDWREHGAVTPVKNQGSCGACWSFSATGAL 161
             V G R            P++    +PK  DWRE G VTPVKNQG CG+CW+FSA+G L
Sbjct: 90  QIVNGYRHQKHKKGRLFQEPLML--QIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCL 147

Query: 162 EGAHFLSTGKLVSLSEQQLVDCDHECDPEEAGSCDSGCKGGLMNSAFEYILNNGGVMREE 221
           EG  FL TGKL+SLSEQ LVDC H+         + GC GGLM+ AF+YI  NGG+  EE
Sbjct: 148 EGQMFLKTGKLISLSEQNLVDCSHD-------QGNQGCNGGLMDFAFQYIKENGGLDSEE 200

Query: 222 DYPYSGTAGGTCKFDQTKIAASVANFSVVSRDEDQIAANLVKNGPLAVAINAVY--MQTY 279
            YPY     G+CK+      A+   F  + + E  +   +   GP++VA++A +  +Q Y
Sbjct: 201 SYPYE-AKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFY 259

Query: 280 VGGVSC-PYVCSKKLNHGVLLVGYGSESYAPIRMKQKPYWIIKNSWGENWGENGYYKICR 338
             G+   P   SK L+HGVL+VGYG   Y      +  YW++KNSWG+ WG +GY KI +
Sbjct: 260 SSGIYYEPNCSSKDLDHGVLVVGYG---YEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAK 316

Query: 339 GR-NVCGVDSMVS 350
            R N CG+ +  S
Sbjct: 317 DRNNHCGLATAAS 329


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.320    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,282,007
Number of Sequences: 164201
Number of extensions: 1997088
Number of successful extensions: 4665
Number of sequences better than 10.0: 182
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3897
Number of HSP's gapped (non-prelim): 218
length of query: 360
length of database: 59,974,054
effective HSP length: 111
effective length of query: 249
effective length of database: 41,747,743
effective search space: 10395188007
effective search space used: 10395188007
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)