BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0253.11
         (359 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

KELC_ANOST (Q70JS2) Ring canal kelch homolog (Kelch-like protein...    47  6e-05
KH18_HUMAN (O94889) Kelch-like protein 18                              47  7e-05
CALI_HUMAN (Q13939) Calicin                                            47  1e-04
CALI_BOVIN (Q28068) Calicin                                            46  1e-04
Y469_HUMAN (Q9UJP4) Hypothetical protein KIAA0469                      45  4e-04
SCRA_LIMPO (Q25390) Alpha-scruin                                       44  6e-04
SCRB_LIMPO (Q25386) Beta-scruin                                        42  0.002
KBTA_HUMAN (O60662) Kelch repeat and BTB domain containing prote...    42  0.003
YR47_CAEEL (Q09563) Hypothetical protein F47D12.7 in chromosome III    41  0.005
KELC_DROME (Q04652) Ring canal kelch protein [Contains: Kelch sh...    40  0.012
KH14_HUMAN (Q9P2G3) Kelch-like protein 14 (Fragment)                   39  0.016
KBTA_RAT (Q9ER30) Kelch repeat and BTB domain containing protein...    39  0.016
KEAP_HUMAN (Q14145) Kelch-like ECH-associated protein 1 (Cytosol...    39  0.027
IPP_HUMAN (Q9Y573) Actin-binding protein IPP (MIPP protein)            39  0.027
KHL5_HUMAN (Q96PQ7) Kelch-like protein 5                               38  0.045
KEAP_MOUSE (Q9Z2X8) Kelch-like ECH-associated protein 1 (Cytosol...    38  0.045
GAOA_DACDE (Q01745) Galactose oxidase precursor (EC 1.1.3.9) (GAO)     38  0.045
GAN_HUMAN (Q9H2C0) Gigaxonin (Kelch-like protein 16)                   38  0.045
YNV6_CAEEL (P34569) Hypothetical protein T16H12.6 in chromosome III    37  0.059
KEAP_RAT (P57790) Kelch-like ECH-associated protein 1 (Cytosolic...    37  0.059

>KELC_ANOST (Q70JS2) Ring canal kelch homolog (Kelch-like protein 1)
           [Contains: Kelch short protein]
          Length = 1499

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 51/161 (31%), Positives = 66/161 (40%), Gaps = 11/161 (6%)

Query: 74  VKATTNPVYRLSVFEPETGNWSELTMPP---EFDSGSGLPMFCQIAGVGYE---LVVMGG 127
           V    N +Y +  F+  TG  S     P   E+   + +       GVG     L  +GG
Sbjct: 438 VAVLNNCIYAVGGFDGSTGLSSAEMFDPKRQEWRLIASMSTRRSSVGVGVVNGLLYAVGG 497

Query: 128 WDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALK 187
           +D  S +   SV  YN  + TW + A+M    R   A     D  +Y  GGHD      K
Sbjct: 498 YDGASRQCLASVERYNPSTDTWTQIAEM--SARRSGAGVGVLDNILYAVGGHDGPL-VRK 554

Query: 188 SALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGG 228
           S  AYD A + W  + DMA  R     V     G L VVGG
Sbjct: 555 SVEAYDPATNTWRAVGDMAFCRRNAGVVAHN--GMLYVVGG 593


>KH18_HUMAN (O94889) Kelch-like protein 18
          Length = 509

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 56/206 (27%), Positives = 80/206 (38%), Gaps = 32/206 (15%)

Query: 69  CGGLLVKATTNPVYRLSVFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGW 128
           CGG    ++ + V     + PET  W+ +T      S +G+ +F         + V GG 
Sbjct: 323 CGGYDGNSSLSSV---ETYSPETDKWTVVTSMSSNRSAAGVTVF------EGRIYVSGGH 373

Query: 129 DPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKS 188
           D    +  +SV  YN  +ATW   A M        A +      ++V GG+D     L  
Sbjct: 374 D--GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGS--KMFVCGGYD-GSGFLSI 428

Query: 189 ALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGRFERSAEEFDVDT 248
           A  Y    D+W  +  M   R     V     G+L  VGGY  + Q     S E +D +T
Sbjct: 429 AEMYSSVADQWCLIVPMHTRRSRVSLV--ASCGRLYAVGGY--DGQSNLS-SVEMYDPET 483

Query: 249 WQWGPVEEEFLDCGT--CPRTCLDGG 272
                      DC T   P  C +GG
Sbjct: 484 -----------DCWTFMAPMACHEGG 498


>CALI_HUMAN (Q13939) Calicin
          Length = 588

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 25/84 (29%), Positives = 45/84 (52%), Gaps = 3/84 (3%)

Query: 122 LVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDE 181
           +V++GG      + ++ VF Y      W + +DMP       A ++   R +Y++GG  E
Sbjct: 281 VVILGGQKAHG-QFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAG--RYIYISGGTTE 337

Query: 182 EKNALKSALAYDVANDEWVPLPDM 205
           + + LK+A  YD+ ++ W  LPD+
Sbjct: 338 QISGLKTAWRYDMDDNSWTKLPDL 361


>CALI_BOVIN (Q28068) Calicin
          Length = 588

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 25/84 (29%), Positives = 45/84 (52%), Gaps = 3/84 (3%)

Query: 122 LVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDE 181
           +V++GG      K ++ VF Y      W + ++MP       A ++   R +Y++GG  E
Sbjct: 281 VVILGGQKAHG-KFNDGVFAYIIQENLWLKLSEMPYRAAALSATSAG--RYIYISGGTTE 337

Query: 182 EKNALKSALAYDVANDEWVPLPDM 205
           + + LK+A  YD+ ++ W  LPD+
Sbjct: 338 QISGLKTAWRYDMDDNSWTKLPDL 361


>Y469_HUMAN (Q9UJP4) Hypothetical protein KIAA0469
          Length = 539

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 61/242 (25%), Positives = 86/242 (35%), Gaps = 43/242 (17%)

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFLS 146
           + P+TG W  L   P+   G        I  +G ++ V GG D    +  + V+ YN   
Sbjct: 307 YNPQTGQWRYLAEFPDHLGGG-----YSIVALGNDIYVTGGSDGS--RLYDCVWRYNSSV 359

Query: 147 ATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMA 206
             W   A M       +  +S  D  +YV      E+        YD   D W  L  M 
Sbjct: 360 NEWAEVAPMLKARE--YHSSSVLDGLLYVVAADSTER--------YDHTTDSWEALQPMT 409

Query: 207 RERDECKAVFRGGAGKLRVVGGYCTEMQGRFERSAEEFDVDTWQWGPVEEEFLDCGT--- 263
              D C        G+L  +G     + G+     + +D DT  W       +DCG    
Sbjct: 410 YPMDNCSTT--ACRGRLYAIG----SLAGKETMVMQCYDPDTDLW-----SLVDCGQLPP 458

Query: 264 ---CPRTCLDGGDAMYMCRGG----DVVALQGNTWQTVAKVPSEIR-NVACMGAWERSLL 315
               P+T    G  MY  R      DV     N W    K+PS  + N      W+  L+
Sbjct: 459 WSFAPKTATLNG-LMYFVRDDSAEVDVYNPTRNEWD---KIPSMNQVNFQAGQHWKHRLV 514

Query: 316 LI 317
           LI
Sbjct: 515 LI 516


>SCRA_LIMPO (Q25390) Alpha-scruin
          Length = 918

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 41/157 (26%), Positives = 64/157 (40%), Gaps = 15/157 (9%)

Query: 70  GGLLVKATTNPVYRLSVFE--PETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGG 127
           GG+ ++   N  Y  SVF+  P    W      P+  +      +   A     + + GG
Sbjct: 595 GGVDLRDPMNIAYGRSVFQYHPLKDRWEFFGYMPQPRN------YHAAAYYRSAIYITGG 648

Query: 128 WDPE--SWK---ASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEE 182
           +DP+  +W    A+ + F+Y   S  W R  DM    R+  +     D  +Y  GG D+ 
Sbjct: 649 YDPDVRTWGEMVATKTTFVYELASKNWTRMGDMRCA-RSHHSLLVFND-VLYAIGGRDDI 706

Query: 183 KNALKSALAYDVANDEWVPLPDMARERDECKAVFRGG 219
              + S  +YD  ++EW     M   R    AV  GG
Sbjct: 707 GRLVSSVESYDHESNEWTMEKSMPSPRMGMAAVAHGG 743



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/213 (25%), Positives = 89/213 (40%), Gaps = 35/213 (16%)

Query: 27  VTAACKGWNTEIQSPEFRRRRRVTGNTQKILVTAQARFDSDTCGGLLVKATTNPVYRLSV 86
           +T   K W         R    VT   ++I V     F      G ++ A       + +
Sbjct: 160 LTVQTKQWRKRADMRYARAHHNVTVMDERIFV-----FGGRDSNGEILAA-------VEM 207

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWK-----ASNSVFI 141
           +EPE   W+ L   PE   GS +       G+ Y   V+GG      K      SN +F 
Sbjct: 208 YEPEMDQWTTLASIPEPMMGSAI---ANNEGIIY---VIGGVTTNKEKKPEGNLSNKIFC 261

Query: 142 YNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHD-EEKNALKSALAYDVANDEWV 200
           ++ L+  W R   +   PR F A T+ Q++ +++ GG +  E+  L S  + DV + +  
Sbjct: 262 FDPLNNKWYRKPSL-SSPRAFSAATT-QNKKIWIWGGANLSEEGLLSSIDSIDVLDPKKG 319

Query: 201 PLP-----DMARERDECKAVFRGGAGKLRVVGG 228
            L      ++A+    C AV + GA  + +VGG
Sbjct: 320 TLEHHMNFELAK---HCHAVAKTGA-HVFIVGG 348



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 37/159 (23%), Positives = 59/159 (36%), Gaps = 17/159 (10%)

Query: 86  VFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELV-VMGGWDP-----ESWKASNSV 139
           V+ P+   W+  T   E       P      G  +  V V GG++P        +A+ + 
Sbjct: 105 VYHPDRNKWNFYTTMME-------PRTYHAVGYFHRRVYVFGGYNPLHCRKGKMQATATT 157

Query: 140 FIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEW 199
           F     +  WR+ ADM    R     T   D  ++V GG D     L +   Y+   D+W
Sbjct: 158 FQLTVQTKQWRKRADMRYA-RAHHNVTV-MDERIFVFGGRDSNGEILAAVEMYEPEMDQW 215

Query: 200 VPLPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGRFE 238
             L  +        +      G + V+GG  T  + + E
Sbjct: 216 TTLASIPEPM--MGSAIANNEGIIYVIGGVTTNKEKKPE 252


>SCRB_LIMPO (Q25386) Beta-scruin
          Length = 916

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 59/209 (28%), Positives = 78/209 (37%), Gaps = 34/209 (16%)

Query: 40  SPEFRRRRRVTGNTQKILVTAQARFDSDTCGGLLVKATTNPVYRLSVFE--PETGNWSEL 97
           +P +  R   TG+ Q   +           GG+  +   N  Y  SVF+  P    W   
Sbjct: 566 TPYYMSRFHATGDIQDTSIPVIIAI-----GGVDPQDPMNVSYGRSVFQYHPLKDRW--- 617

Query: 98  TMPPEFDSGSGLPMFCQIAGVGYELV-VMGGWDPE-----SWKASNSVFIYNFLSATWRR 151
               EF     LP     A      + V GG DP         A+   F+Y   S  W R
Sbjct: 618 ----EFFGFMSLPRNHHAAAYYRGAIYVTGGCDPHIRCWGEMVATKMTFVYRLSSNKWTR 673

Query: 152 GADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEW-----VPLPDMA 206
            ADM    R+  +     D ++YV GG D+      S  +Y  A DEW     +PLP M 
Sbjct: 674 VADMHSA-RSHHSMVVFND-SIYVIGGRDDSGRLSASVESYVPALDEWNQEKPMPLPRMG 731

Query: 207 RERDECKAVFRGGAGKLRVVGGYCTEMQG 235
                  AV   G G L V+GG  +   G
Sbjct: 732 ------MAVVSHG-GYLWVMGGVTSTKGG 753



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 51/214 (23%), Positives = 86/214 (39%), Gaps = 37/214 (17%)

Query: 27  VTAACKGWNTEIQSPEFRRRRRVTGNTQKILVTAQARFDSDTCGGLLVKATTNPVYRLSV 86
           +T   K W      P  R    VT   ++I V        D+ G ++          + +
Sbjct: 160 LTLDVKQWRRRADMPSARAHHGVTIMDERIFVFG----GKDSNGNIIAS--------VEM 207

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWK-----ASNSVFI 141
           +EPE   W+ L   PE   GS +       G+ Y   V+GG   +  K      SN ++ 
Sbjct: 208 YEPELDQWTSLASIPEPLMGSAV---TNNEGLIY---VVGGLTTKKEKNQEGVLSNKIYC 261

Query: 142 YNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHD-EEKNALKSALAYDVANDEWV 200
           ++ L+  W R   +P  PR F + T+ Q++ +++ GG    E   L S  + D+    W 
Sbjct: 262 FDPLNNKWYRKPPLP-CPRAFASATT-QNKKIWIWGGASLSEGGTLASTTSVDI----WD 315

Query: 201 PLPDMARER------DECKAVFRGGAGKLRVVGG 228
           P      +         C AV + G  ++ ++GG
Sbjct: 316 PKKGRFEQHLIFDSPKHCLAVTKAGT-QVFIIGG 348



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 31/119 (26%), Positives = 50/119 (41%), Gaps = 9/119 (7%)

Query: 121 ELVVMGGWDP-----ESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYV 175
           ++ + GG++P        +A+++ F        WRR ADMP   R     T   D  ++V
Sbjct: 134 KVYLFGGYNPLHCIKGKMQATSTTFQLTLDVKQWRRRADMPSA-RAHHGVTI-MDERIFV 191

Query: 176 AGGHDEEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYCTEMQ 234
            GG D   N + S   Y+   D+W  L  +        +      G + VVGG  T+ +
Sbjct: 192 FGGKDSNGNIIASVEMYEPELDQWTSLASIPEPL--MGSAVTNNEGLIYVVGGLTTKKE 248


>KBTA_HUMAN (O60662) Kelch repeat and BTB domain containing protein
           10 (Kelch-related protein 1) (Kel-like protein 23)
           (Sarcosin)
          Length = 606

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 13/172 (7%)

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFLS 146
           ++P    W+E+   P    G  +     I+  G    + G  D +  K +N VFI+N   
Sbjct: 420 YDPVAAKWNEVKKLPIKVYGHNV-----ISHKGMIYCLGGKTDDK--KCTNRVFIFNPKK 472

Query: 147 ATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMA 206
             W+  A M   PR+ F     + + V +AGG  E+     S  A+D+  ++W  + +  
Sbjct: 473 GDWKDLAPMKI-PRSMFGVAVHKGKIV-IAGGVTED-GLSASVEAFDLTTNKWDVMTEFP 529

Query: 207 RERDECKAVFRGGAGKLRVVGGYCTEMQGRFERSAEEFDVDTWQWGPVEEEF 258
           +ER     V    AG L  +GG+        E +  E + D W++   ++E+
Sbjct: 530 QERSSISLV--SLAGSLYAIGGFAMIQLESKEFAPTEVN-DIWKYEDDKKEW 578


>YR47_CAEEL (Q09563) Hypothetical protein F47D12.7 in chromosome III
          Length = 579

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 51/223 (22%), Positives = 88/223 (38%), Gaps = 18/223 (8%)

Query: 36  TEIQSPEFRRRRRVTGNTQKILVTAQARFDSDTCGGLLVKATTNPVYRLSVFEPETGNWS 95
           T+     F RR +      +++ T Q   D+  C G    A+     ++ V    +  W 
Sbjct: 237 TQFAQRNFSRRPQPDATKYEVIRTRQP-MDAIVCFGGW--ASRGVAQKIEVCNTRSDRWQ 293

Query: 96  ELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFLSATWRRGADM 155
                  +D  +    +  I  V  +L+V GG+D    K   +  +++  +  WRRGA+M
Sbjct: 294 TCNF--NYDIPNIHRAYHGIEVVEDKLIVYGGFD--GIKQFQTTVLFDLSTKEWRRGANM 349

Query: 156 PGGPRTFFACTSDQD---RTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMARERDEC 212
               R +       D   R +  A G     + LK+A  YD   D+W  + +M + R + 
Sbjct: 350 -NDKRCYVTSARVNDSYGRPLVFACGGMNGVSRLKTAEMYDYRADQWTEVANMTQMRSDG 408

Query: 213 KAVFRGGAGKLRVVGGYCTEMQGR-FERSAEEFDVDTWQWGPV 254
             V      K+  +GG+     GR   +  E +D     W P+
Sbjct: 409 AVVTID--NKIVAIGGF----DGRNIHQGGEVYDPVLDLWHPL 445


>KELC_DROME (Q04652) Ring canal kelch protein [Contains: Kelch short
           protein]
          Length = 1477

 Score = 39.7 bits (91), Expect = 0.012
 Identities = 40/143 (27%), Positives = 62/143 (42%), Gaps = 11/143 (7%)

Query: 86  VFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFL 145
           +++P+T  W  +       S  G+ +   + G+ Y    +GG+D  + +  +SV  YN  
Sbjct: 515 MYDPKTDIWRFIASMSTRRSSVGVGV---VHGLLY---AVGGYDGFTRQCLSSVERYNPD 568

Query: 146 SATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDM 205
           + TW   A+M    R   A     +  +Y  GGHD      +S  AYD   + W  + DM
Sbjct: 569 TDTWVNVAEM--SSRRSGAGVGVLNNILYAVGGHDGPM-VRRSVEAYDCETNSWRSVADM 625

Query: 206 ARERDECKAVFRGGAGKLRVVGG 228
           +  R     V   G   L VVGG
Sbjct: 626 SYCRRNAGVVAHDGL--LYVVGG 646


>KH14_HUMAN (Q9P2G3) Kelch-like protein 14 (Fragment)
          Length = 652

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 36/133 (27%), Positives = 58/133 (43%), Gaps = 12/133 (9%)

Query: 70  GGLLVKATTNPVYRLSVFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGG-- 127
           GGL       P   +  ++ E   W  LT+ P ++S         +  V   L V+GG  
Sbjct: 352 GGLPPGPDRLPSNLVQYYDDEKKTWKILTIMP-YNSAHHC-----VVEVENFLFVLGGED 405

Query: 128 -WDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNAL 186
            W+P    ++N V  Y+    +W +   M     +F+AC    D+ +YV GG + E   L
Sbjct: 406 QWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACR--LDKHLYVIGGRN-ETGYL 462

Query: 187 KSALAYDVANDEW 199
            S   Y++  +EW
Sbjct: 463 SSVECYNLETNEW 475



 Score = 33.5 bits (75), Expect = 0.85
 Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 12/135 (8%)

Query: 122 LVVMGGWDPESWKA-SNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHD 180
           L+++GG  P   +  SN V  Y+    TW+    MP    +   C  + +  ++V GG D
Sbjct: 348 LLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYN--SAHHCVVEVENFLFVLGGED 405

Query: 181 E----EKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGR 236
           +     K++      YD   + W+ LP M   R    A        L V+GG     +  
Sbjct: 406 QWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLD--KHLYVIGG---RNETG 460

Query: 237 FERSAEEFDVDTWQW 251
           +  S E ++++T +W
Sbjct: 461 YLSSVECYNLETNEW 475


>KBTA_RAT (Q9ER30) Kelch repeat and BTB domain containing protein 10
           (Kelch-related protein 1) (Kel-like protein 23)
           (Sarcosin)
          Length = 606

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 36/184 (19%), Positives = 74/184 (39%), Gaps = 14/184 (7%)

Query: 121 ELVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHD 180
           ++ V+ G D ++  + +SV  Y+ ++A W    ++P   + +       +  +Y  GG  
Sbjct: 399 KIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLP--IKVYGHNVISHNGMIYCLGGKT 456

Query: 181 EEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGRFERS 240
           ++K        Y+    +W  L  M   R           GK+ + GG     +     S
Sbjct: 457 DDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIH--KGKIVIAGGV---TEDGLSAS 511

Query: 241 AEEFDVDTWQWGPVEEEFLDCGTCPRTCLDGGDAMYMCRGGDVVALQGNTWQTVAKVPSE 300
            E FD+ T +W  + E   +  +     L G  ++Y   G  ++ L+   +      P+E
Sbjct: 512 VEAFDLKTNKWEVMTEFPQERSSISLVSLAG--SLYAIGGFAMIQLESKEF-----APTE 564

Query: 301 IRNV 304
           + ++
Sbjct: 565 VNDI 568


>KEAP_HUMAN (Q14145) Kelch-like ECH-associated protein 1 (Cytosolic
           inhibitor of Nrf2)
          Length = 624

 Score = 38.5 bits (88), Expect = 0.027
 Identities = 39/132 (29%), Positives = 53/132 (39%), Gaps = 11/132 (8%)

Query: 78  TNPVYRLSVFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASN 137
           TN +     + PE   W  +T      SG+G+   C +    Y     GG+D +     N
Sbjct: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGV---CVLHNCIY---AAGGYDGQD--QLN 532

Query: 138 SVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVAND 197
           SV  Y+  + TW   A M    R+    T  Q R +YV GG+D     L S   YD   D
Sbjct: 533 SVERYDVETETWTFVAPMK-HRRSALGITVHQGR-IYVLGGYDGH-TFLDSVECYDPDTD 589

Query: 198 EWVPLPDMARER 209
            W  +  M   R
Sbjct: 590 TWSEVTRMTSGR 601


>IPP_HUMAN (Q9Y573) Actin-binding protein IPP (MIPP protein)
          Length = 584

 Score = 38.5 bits (88), Expect = 0.027
 Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 10/123 (8%)

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFLS 146
           ++P T  W+ +        G G+   C   G  Y L   GGW     +  N++  ++   
Sbjct: 363 YDPVTKQWTTVASMNHPRCGLGV---CVCYGAIYAL---GGW--VGAEIGNTIERFDPDE 414

Query: 147 ATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMA 206
             W    +M    R +F C   Q   +YV GG   E   L+S   YD  +  W PLP M 
Sbjct: 415 NKWEVVGNMAVS-RYYFGCCEMQG-LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMG 472

Query: 207 RER 209
             R
Sbjct: 473 TRR 475



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 25/93 (26%), Positives = 43/93 (45%), Gaps = 6/93 (6%)

Query: 113 CQIAGVGYELVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRT 172
           C++ G+ Y   V+GG   E  +   S  +Y+ LS  W      P G R  +   +  +  
Sbjct: 433 CEMQGLIY---VIGGISNEGIEL-RSFEVYDPLSKRW--SPLPPMGTRRAYLGVAALNDC 486

Query: 173 VYVAGGHDEEKNALKSALAYDVANDEWVPLPDM 205
           +Y  GG +E ++AL +   Y    ++WV +  M
Sbjct: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519


>KHL5_HUMAN (Q96PQ7) Kelch-like protein 5
          Length = 755

 Score = 37.7 bits (86), Expect = 0.045
 Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 10/87 (11%)

Query: 173 VYVAGGHDEEKNALKSALA-----YDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVG 227
           +Y  GGHD   + L S L+     YD   D W  +  M+  RD       G   KL  VG
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG--DKLYAVG 714

Query: 228 GYCTEMQGRFERSAEEFDVDTWQWGPV 254
           GY  +    +  + E +D  T +W  V
Sbjct: 715 GYDGQ---AYLNTVEAYDPQTNEWTQV 738


>KEAP_MOUSE (Q9Z2X8) Kelch-like ECH-associated protein 1 (Cytosolic
           inhibitor of Nrf2)
          Length = 624

 Score = 37.7 bits (86), Expect = 0.045
 Identities = 46/173 (26%), Positives = 62/173 (35%), Gaps = 26/173 (15%)

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYE-----LVVMGGWDPESWKASNSVFI 141
           +EPE   W  +            PM  +  GVG       L  +GG+D  +    NS   
Sbjct: 443 YEPERDEWHLVA-----------PMLTRRIGVGVAVLNRLLYAVGGFDGTN--RLNSAEC 489

Query: 142 YNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVP 201
           Y      WR    M         C       +Y AGG+D + + L S   YDV  + W  
Sbjct: 490 YYPERNEWRMITPMNTIRSGAGVCVLHN--CIYAAGGYDGQ-DQLNSVERYDVETETWTF 546

Query: 202 LPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGRFERSAEEFDVDTWQWGPV 254
           +  M   R           GK+ V+GGY       F  S E +D D+  W  V
Sbjct: 547 VAPMRHHRSALGITVH--QGKIYVLGGYDGH---TFLDSVECYDPDSDTWSEV 594



 Score = 37.0 bits (84), Expect = 0.077
 Identities = 38/132 (28%), Positives = 54/132 (40%), Gaps = 11/132 (8%)

Query: 78  TNPVYRLSVFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASN 137
           TN +     + PE   W  +T      SG+G+   C +    Y     GG+D +     N
Sbjct: 481 TNRLNSAECYYPERNEWRMITPMNTIRSGAGV---CVLHNCIY---AAGGYDGQD--QLN 532

Query: 138 SVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVAND 197
           SV  Y+  + TW   A M    R+    T  Q + +YV GG+D     L S   YD  +D
Sbjct: 533 SVERYDVETETWTFVAPM-RHHRSALGITVHQGK-IYVLGGYDGH-TFLDSVECYDPDSD 589

Query: 198 EWVPLPDMARER 209
            W  +  M   R
Sbjct: 590 TWSEVTRMTSGR 601



 Score = 34.3 bits (77), Expect = 0.50
 Identities = 26/84 (30%), Positives = 38/84 (44%), Gaps = 5/84 (5%)

Query: 171 RTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYC 230
           R +Y AGG+  +  +L    AY+ +N  W+ L D+   R        GG   L  VGG  
Sbjct: 326 RLIYTAGGYFRQ--SLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGL--LYAVGGRN 381

Query: 231 TEMQGRFERSAEE-FDVDTWQWGP 253
               G  + SA + ++  T QW P
Sbjct: 382 NSPDGNTDSSALDCYNPMTNQWSP 405


>GAOA_DACDE (Q01745) Galactose oxidase precursor (EC 1.1.3.9) (GAO)
          Length = 680

 Score = 37.7 bits (86), Expect = 0.045
 Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 8/84 (9%)

Query: 168 DQDRTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVG 227
           D +  + V GG+D +K +L     YD ++D W+P PDM   R    +      G++  +G
Sbjct: 275 DGNGQIVVTGGNDAKKTSL-----YDSSSDSWIPGPDMQVARGYQSSATMSD-GRVFTIG 328

Query: 228 GYCTEMQGRFERSAEEFDVDTWQW 251
           G  +   G FE++ E +   +  W
Sbjct: 329 G--SWSGGVFEKNGEVYSPSSKTW 350


>GAN_HUMAN (Q9H2C0) Gigaxonin (Kelch-like protein 16)
          Length = 597

 Score = 37.7 bits (86), Expect = 0.045
 Identities = 44/158 (27%), Positives = 64/158 (39%), Gaps = 17/158 (10%)

Query: 122 LVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDE 181
           L V GG D E+ +  +S   Y+  + TW     M      F     + D  +Y+ GG D 
Sbjct: 328 LFVFGGQD-ENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIV--EIDGMLYILGGEDG 384

Query: 182 EKNALKSALAYDVANDEWVPLPDMARERD-ECKAVFRGGAGKLRVVGGYCTEMQGRFERS 240
           EK  + S   YD+ +  W   PD+   R   C A  +    K+  +GG      G+   S
Sbjct: 385 EKELI-SMECYDIYSKTWTKQPDLTMVRKIGCYAAMK---KKIYAMGG---GSYGKLFES 437

Query: 241 AEEFDVDTWQWGPV----EEEF--LDCGTCPRTCLDGG 272
            E +D  T QW  +    E  F  + CG      + GG
Sbjct: 438 VECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475


>YNV6_CAEEL (P34569) Hypothetical protein T16H12.6 in chromosome III
          Length = 518

 Score = 37.4 bits (85), Expect = 0.059
 Identities = 49/216 (22%), Positives = 87/216 (39%), Gaps = 18/216 (8%)

Query: 43  FRRRRRVTGNTQKILVTAQARFDSDTCGGLLVKATTNPVYRLSVFEPETGNWSELTMPPE 102
           F R+ +      +++ T Q   D+  C G    A+      + VF   +  W        
Sbjct: 183 FSRQPQPDATKYEVIRTRQP-MDAIVCFGGW--ASRGVAQNIEVFNTRSDRWQTCNF--N 237

Query: 103 FDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTF 162
           +D  +    +  I  V  +L+V GG++    +   +  +++  +  WR GA+M    R +
Sbjct: 238 YDIPNIRRAYHGIEVVEDKLIVYGGFN--GTQQFQTTVLFDLSTKEWRSGANM-NDKRCY 294

Query: 163 FACTSDQD---RTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGG 219
                  D   R +  A G     + LK+A  YD   D+W  + +MA+ R +   V    
Sbjct: 295 VTSARINDSHGRPLIFACGGMNGVSRLKTAEMYDYRADQWSEVANMAQMRSDGAVVTID- 353

Query: 220 AGKLRVVGGYCTEMQGR-FERSAEEFDVDTWQWGPV 254
             K+ V+GG+     GR   +  E +D     W P+
Sbjct: 354 -NKIVVIGGF----DGRNIHQGGEVYDPVLDLWHPL 384



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 37/162 (22%), Positives = 62/162 (37%), Gaps = 26/162 (16%)

Query: 69  CGGLLVKATTNPVYRLS---VFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVM 125
           CGG+      N V RL    +++     WSE+    +  S         +  +  ++VV+
Sbjct: 312 CGGM------NGVSRLKTAEMYDYRADQWSEVANMAQMRSDGA------VVTIDNKIVVI 359

Query: 126 GGWDPESWKASNSVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNA 185
           GG+D  +      V  Y+ +   W   +      RT     S  ++   + GG +  +  
Sbjct: 360 GGFDGRNIHQGGEV--YDPVLDLWHPLSSNMRTRRTGCTAVSIMNQVCMIIGGFNGNRR- 416

Query: 186 LKSALAYDVANDEWVPLPDM--------ARERDECKAVFRGG 219
           L SA  YD+    W P+P +        A + D C     GG
Sbjct: 417 LDSAEIYDMREGLWHPVPSLHTARSNFSACQMDTCSIYVAGG 458


>KEAP_RAT (P57790) Kelch-like ECH-associated protein 1 (Cytosolic
           inhibitor of Nrf2) (INrf2)
          Length = 624

 Score = 37.4 bits (85), Expect = 0.059
 Identities = 45/173 (26%), Positives = 62/173 (35%), Gaps = 26/173 (15%)

Query: 87  FEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYE-----LVVMGGWDPESWKASNSVFI 141
           +EP+   W  +            PM  +  GVG       L  +GG+D  +    NS   
Sbjct: 443 YEPDRDEWHLVA-----------PMLTRRIGVGVAVLNRLLYAVGGFDGTN--RLNSAEC 489

Query: 142 YNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVANDEWVP 201
           Y      WR    M         C       +Y AGG+D + + L S   YDV  + W  
Sbjct: 490 YYPERNEWRMITPMNTIRSGAGVCVLHS--CIYAAGGYDGQ-DQLNSVERYDVETETWTF 546

Query: 202 LPDMARERDECKAVFRGGAGKLRVVGGYCTEMQGRFERSAEEFDVDTWQWGPV 254
           +  M   R           G++ V+GGY       F  S E +D DT  W  V
Sbjct: 547 VASMKHRRSALGIAVH--QGRIYVLGGYDGH---TFLDSVECYDPDTDTWSEV 594



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 36/122 (29%), Positives = 49/122 (39%), Gaps = 11/122 (9%)

Query: 78  TNPVYRLSVFEPETGNWSELTMPPEFDSGSGLPMFCQIAGVGYELVVMGGWDPESWKASN 137
           TN +     + PE   W  +T      SG+G+   C +    Y     GG+D +     N
Sbjct: 481 TNRLNSAECYYPERNEWRMITPMNTIRSGAGV---CVLHSCIY---AAGGYDGQD--QLN 532

Query: 138 SVFIYNFLSATWRRGADMPGGPRTFFACTSDQDRTVYVAGGHDEEKNALKSALAYDVAND 197
           SV  Y+  + TW   A M    R+       Q R +YV GG+D     L S   YD   D
Sbjct: 533 SVERYDVETETWTFVASMK-HRRSALGIAVHQGR-IYVLGGYDGH-TFLDSVECYDPDTD 589

Query: 198 EW 199
            W
Sbjct: 590 TW 591



 Score = 34.3 bits (77), Expect = 0.50
 Identities = 26/84 (30%), Positives = 38/84 (44%), Gaps = 5/84 (5%)

Query: 171 RTVYVAGGHDEEKNALKSALAYDVANDEWVPLPDMARERDECKAVFRGGAGKLRVVGGYC 230
           R +Y AGG+  +  +L    AY+ +N  W+ L D+   R        GG   L  VGG  
Sbjct: 326 RLIYTAGGYFRQ--SLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGL--LYAVGGRN 381

Query: 231 TEMQGRFERSAEE-FDVDTWQWGP 253
               G  + SA + ++  T QW P
Sbjct: 382 NSPDGNTDSSALDCYNPMTNQWSP 405


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.320    0.137    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,399,763
Number of Sequences: 164201
Number of extensions: 2119583
Number of successful extensions: 3799
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 3739
Number of HSP's gapped (non-prelim): 98
length of query: 359
length of database: 59,974,054
effective HSP length: 111
effective length of query: 248
effective length of database: 41,747,743
effective search space: 10353440264
effective search space used: 10353440264
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)